-- dump date   	20140619_164208
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
323098000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
323098000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
323098000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323098000004	Walker A motif; other site
323098000005	ATP binding site [chemical binding]; other site
323098000006	Walker B motif; other site
323098000007	arginine finger; other site
323098000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
323098000009	DnaA box-binding interface [nucleotide binding]; other site
323098000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
323098000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
323098000012	putative DNA binding surface [nucleotide binding]; other site
323098000013	dimer interface [polypeptide binding]; other site
323098000014	beta-clamp/clamp loader binding surface; other site
323098000015	beta-clamp/translesion DNA polymerase binding surface; other site
323098000016	recombination protein F; Reviewed; Region: recF; PRK00064
323098000017	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
323098000018	Walker A/P-loop; other site
323098000019	ATP binding site [chemical binding]; other site
323098000020	Q-loop/lid; other site
323098000021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
323098000022	ABC transporter signature motif; other site
323098000023	Walker B; other site
323098000024	D-loop; other site
323098000025	H-loop/switch region; other site
323098000026	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
323098000027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323098000028	Mg2+ binding site [ion binding]; other site
323098000029	G-X-G motif; other site
323098000030	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
323098000031	anchoring element; other site
323098000032	dimer interface [polypeptide binding]; other site
323098000033	ATP binding site [chemical binding]; other site
323098000034	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
323098000035	active site
323098000036	putative metal-binding site [ion binding]; other site
323098000037	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
323098000038	PAN domain; Region: PAN_4; pfam14295
323098000039	Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100
323098000040	putative binding site; other site
323098000041	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323098000042	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
323098000043	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323098000044	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
323098000045	Ligand Binding Site [chemical binding]; other site
323098000046	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
323098000047	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
323098000048	Protein of unknown function (DUF2778); Region: DUF2778; pfam10908
323098000049	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
323098000050	Glycoprotease family; Region: Peptidase_M22; pfam00814
323098000051	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
323098000052	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
323098000053	Coenzyme A binding pocket [chemical binding]; other site
323098000054	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
323098000055	metal binding site 2 [ion binding]; metal-binding site
323098000056	putative DNA binding helix; other site
323098000057	metal binding site 1 [ion binding]; metal-binding site
323098000058	dimer interface [polypeptide binding]; other site
323098000059	structural Zn2+ binding site [ion binding]; other site
323098000060	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
323098000061	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
323098000062	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
323098000063	FeS/SAM binding site; other site
323098000064	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
323098000065	KH domain; Region: KH_1; pfam00013
323098000066	PhoH-like protein; Region: PhoH; pfam02562
323098000067	metal-binding heat shock protein; Provisional; Region: PRK00016
323098000068	FOG: CBS domain [General function prediction only]; Region: COG0517
323098000069	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
323098000070	Transporter associated domain; Region: CorC_HlyC; smart01091
323098000071	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
323098000072	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
323098000073	putative active site [active]
323098000074	catalytic triad [active]
323098000075	putative dimer interface [polypeptide binding]; other site
323098000076	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
323098000077	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
323098000078	non-specific DNA binding site [nucleotide binding]; other site
323098000079	salt bridge; other site
323098000080	sequence-specific DNA binding site [nucleotide binding]; other site
323098000081	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
323098000082	Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576
323098000083	Sm and related proteins; Region: Sm_like; cl00259
323098000084	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
323098000085	putative oligomer interface [polypeptide binding]; other site
323098000086	putative RNA binding site [nucleotide binding]; other site
323098000087	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
323098000088	NusA N-terminal domain; Region: NusA_N; pfam08529
323098000089	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
323098000090	RNA binding site [nucleotide binding]; other site
323098000091	homodimer interface [polypeptide binding]; other site
323098000092	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
323098000093	G-X-X-G motif; other site
323098000094	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
323098000095	G-X-X-G motif; other site
323098000096	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
323098000097	hypothetical protein; Provisional; Region: PRK09190
323098000098	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
323098000099	putative RNA binding cleft [nucleotide binding]; other site
323098000100	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
323098000101	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
323098000102	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
323098000103	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
323098000104	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
323098000105	G1 box; other site
323098000106	putative GEF interaction site [polypeptide binding]; other site
323098000107	GTP/Mg2+ binding site [chemical binding]; other site
323098000108	Switch I region; other site
323098000109	G2 box; other site
323098000110	G3 box; other site
323098000111	Switch II region; other site
323098000112	G4 box; other site
323098000113	G5 box; other site
323098000114	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
323098000115	Translation-initiation factor 2; Region: IF-2; pfam11987
323098000116	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
323098000117	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
323098000118	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
323098000119	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
323098000120	RNA binding site [nucleotide binding]; other site
323098000121	active site
323098000122	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
323098000123	16S/18S rRNA binding site [nucleotide binding]; other site
323098000124	S13e-L30e interaction site [polypeptide binding]; other site
323098000125	25S rRNA binding site [nucleotide binding]; other site
323098000126	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
323098000127	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
323098000128	RNase E interface [polypeptide binding]; other site
323098000129	trimer interface [polypeptide binding]; other site
323098000130	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
323098000131	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
323098000132	RNase E interface [polypeptide binding]; other site
323098000133	trimer interface [polypeptide binding]; other site
323098000134	active site
323098000135	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
323098000136	putative nucleic acid binding region [nucleotide binding]; other site
323098000137	G-X-X-G motif; other site
323098000138	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
323098000139	RNA binding site [nucleotide binding]; other site
323098000140	domain interface; other site
323098000141	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
323098000142	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
323098000143	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
323098000144	dimerization interface [polypeptide binding]; other site
323098000145	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
323098000146	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
323098000147	dimer interface [polypeptide binding]; other site
323098000148	active site
323098000149	heme binding site [chemical binding]; other site
323098000150	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
323098000151	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
323098000152	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
323098000153	putative GSH binding site (G-site) [chemical binding]; other site
323098000154	putative C-terminal domain interface [polypeptide binding]; other site
323098000155	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
323098000156	dimer interface [polypeptide binding]; other site
323098000157	N-terminal domain interface [polypeptide binding]; other site
323098000158	putative substrate binding pocket (H-site) [chemical binding]; other site
323098000159	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505
323098000160	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
323098000161	NAD binding site [chemical binding]; other site
323098000162	homotetramer interface [polypeptide binding]; other site
323098000163	homodimer interface [polypeptide binding]; other site
323098000164	substrate binding site [chemical binding]; other site
323098000165	active site
323098000166	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
323098000167	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
323098000168	dimer interface [polypeptide binding]; other site
323098000169	active site
323098000170	3-hydroxydecanoyl-(acyl carrier protein) dehydratase; Validated; Region: PRK05174
323098000171	active site 2 [active]
323098000172	active site 1 [active]
323098000173	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
323098000174	metal binding site 2 [ion binding]; metal-binding site
323098000175	putative DNA binding helix; other site
323098000176	metal binding site 1 [ion binding]; metal-binding site
323098000177	dimer interface [polypeptide binding]; other site
323098000178	structural Zn2+ binding site [ion binding]; other site
323098000179	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807
323098000180	Bacterial SH3 domain; Region: SH3_4; pfam06347
323098000181	Bacterial SH3 domain; Region: SH3_4; pfam06347
323098000182	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
323098000183	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
323098000184	dimerization interface [polypeptide binding]; other site
323098000185	ligand binding site [chemical binding]; other site
323098000186	NADP binding site [chemical binding]; other site
323098000187	catalytic site [active]
323098000188	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
323098000189	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
323098000190	ATP binding site [chemical binding]; other site
323098000191	substrate interface [chemical binding]; other site
323098000192	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
323098000193	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
323098000194	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
323098000195	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
323098000196	DNA binding site [nucleotide binding]
323098000197	catalytic residue [active]
323098000198	H2TH interface [polypeptide binding]; other site
323098000199	putative catalytic residues [active]
323098000200	turnover-facilitating residue; other site
323098000201	intercalation triad [nucleotide binding]; other site
323098000202	8OG recognition residue [nucleotide binding]; other site
323098000203	putative reading head residues; other site
323098000204	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
323098000205	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
323098000206	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323098000207	S-adenosylmethionine binding site [chemical binding]; other site
323098000208	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
323098000209	ABC1 family; Region: ABC1; cl17513
323098000210	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
323098000211	active site
323098000212	ATP binding site [chemical binding]; other site
323098000213	bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional; Region: PRK13982
323098000214	Flavoprotein; Region: Flavoprotein; pfam02441
323098000215	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
323098000216	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
323098000217	trimer interface [polypeptide binding]; other site
323098000218	active site
323098000219	PAS fold; Region: PAS_7; pfam12860
323098000220	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
323098000221	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323098000222	dimer interface [polypeptide binding]; other site
323098000223	phosphorylation site [posttranslational modification]
323098000224	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323098000225	ATP binding site [chemical binding]; other site
323098000226	Mg2+ binding site [ion binding]; other site
323098000227	G-X-G motif; other site
323098000228	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
323098000229	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
323098000230	Phosphotransferase enzyme family; Region: APH; pfam01636
323098000231	PilZ domain; Region: PilZ; cl01260
323098000232	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
323098000233	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
323098000234	Substrate binding site; other site
323098000235	metal-binding site
323098000236	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
323098000237	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
323098000238	Part of AAA domain; Region: AAA_19; pfam13245
323098000239	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
323098000240	Family description; Region: UvrD_C_2; pfam13538
323098000241	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
323098000242	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
323098000243	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
323098000244	catalytic residues [active]
323098000245	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
323098000246	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
323098000247	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
323098000248	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
323098000249	substrate binding site [chemical binding]; other site
323098000250	active site
323098000251	catalytic residues [active]
323098000252	heterodimer interface [polypeptide binding]; other site
323098000253	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
323098000254	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
323098000255	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323098000256	catalytic residue [active]
323098000257	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
323098000258	active site
323098000259	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
323098000260	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
323098000261	IHF dimer interface [polypeptide binding]; other site
323098000262	IHF - DNA interface [nucleotide binding]; other site
323098000263	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
323098000264	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
323098000265	tandem repeat interface [polypeptide binding]; other site
323098000266	oligomer interface [polypeptide binding]; other site
323098000267	active site residues [active]
323098000268	CysZ-like protein; Reviewed; Region: PRK12768
323098000269	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
323098000270	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
323098000271	catalytic residues [active]
323098000272	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
323098000273	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
323098000274	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
323098000275	Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102
323098000276	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_IV; cd01994
323098000277	Ligand Binding Site [chemical binding]; other site
323098000278	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
323098000279	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
323098000280	putative tRNA-binding site [nucleotide binding]; other site
323098000281	B3/4 domain; Region: B3_4; pfam03483
323098000282	tRNA synthetase B5 domain; Region: B5; smart00874
323098000283	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
323098000284	dimer interface [polypeptide binding]; other site
323098000285	motif 1; other site
323098000286	motif 3; other site
323098000287	motif 2; other site
323098000288	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
323098000289	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
323098000290	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
323098000291	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
323098000292	dimer interface [polypeptide binding]; other site
323098000293	motif 1; other site
323098000294	active site
323098000295	motif 2; other site
323098000296	motif 3; other site
323098000297	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
323098000298	23S rRNA binding site [nucleotide binding]; other site
323098000299	L21 binding site [polypeptide binding]; other site
323098000300	L13 binding site [polypeptide binding]; other site
323098000301	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
323098000302	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
323098000303	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
323098000304	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
323098000305	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
323098000306	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
323098000307	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323098000308	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
323098000309	putative active site [active]
323098000310	heme pocket [chemical binding]; other site
323098000311	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
323098000312	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323098000313	putative active site [active]
323098000314	heme pocket [chemical binding]; other site
323098000315	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323098000316	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
323098000317	putative active site [active]
323098000318	heme pocket [chemical binding]; other site
323098000319	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323098000320	putative active site [active]
323098000321	heme pocket [chemical binding]; other site
323098000322	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
323098000323	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
323098000324	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
323098000325	Uncharacterized conserved protein [Function unknown]; Region: COG2835
323098000326	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
323098000327	Nitrogen regulatory protein P-II; Region: P-II; smart00938
323098000328	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
323098000329	Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738
323098000330	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
323098000331	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
323098000332	active site
323098000333	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
323098000334	catalytic triad [active]
323098000335	dimer interface [polypeptide binding]; other site
323098000336	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333
323098000337	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
323098000338	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
323098000339	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
323098000340	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
323098000341	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
323098000342	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323098000343	homodimer interface [polypeptide binding]; other site
323098000344	catalytic residue [active]
323098000345	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
323098000346	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
323098000347	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
323098000348	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
323098000349	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
323098000350	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
323098000351	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
323098000352	putative catalytic site [active]
323098000353	putative phosphate binding site [ion binding]; other site
323098000354	active site
323098000355	metal binding site A [ion binding]; metal-binding site
323098000356	DNA binding site [nucleotide binding]
323098000357	putative AP binding site [nucleotide binding]; other site
323098000358	putative metal binding site B [ion binding]; other site
323098000359	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
323098000360	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
323098000361	ligand binding site [chemical binding]; other site
323098000362	flexible hinge region; other site
323098000363	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
323098000364	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323098000365	active site
323098000366	phosphorylation site [posttranslational modification]
323098000367	intermolecular recognition site; other site
323098000368	dimerization interface [polypeptide binding]; other site
323098000369	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
323098000370	DNA binding site [nucleotide binding]
323098000371	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
323098000372	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
323098000373	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
323098000374	catalytic residue [active]
323098000375	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
323098000376	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
323098000377	C-terminal domain interface [polypeptide binding]; other site
323098000378	GSH binding site (G-site) [chemical binding]; other site
323098000379	dimer interface [polypeptide binding]; other site
323098000380	C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178
323098000381	dimer interface [polypeptide binding]; other site
323098000382	N-terminal domain interface [polypeptide binding]; other site
323098000383	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
323098000384	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
323098000385	HIGH motif; other site
323098000386	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
323098000387	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
323098000388	active site
323098000389	KMSKS motif; other site
323098000390	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
323098000391	tRNA binding surface [nucleotide binding]; other site
323098000392	Lipopolysaccharide-assembly; Region: LptE; pfam04390
323098000393	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
323098000394	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
323098000395	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
323098000396	ParB-like nuclease domain; Region: ParBc; pfam02195
323098000397	KorB domain; Region: KorB; pfam08535
323098000398	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
323098000399	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
323098000400	P-loop; other site
323098000401	Magnesium ion binding site [ion binding]; other site
323098000402	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
323098000403	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323098000404	S-adenosylmethionine binding site [chemical binding]; other site
323098000405	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
323098000406	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
323098000407	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
323098000408	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
323098000409	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
323098000410	trmE is a tRNA modification GTPase; Region: trmE; cd04164
323098000411	G1 box; other site
323098000412	GTP/Mg2+ binding site [chemical binding]; other site
323098000413	Switch I region; other site
323098000414	G2 box; other site
323098000415	Switch II region; other site
323098000416	G3 box; other site
323098000417	G4 box; other site
323098000418	G5 box; other site
323098000419	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
323098000420	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
323098000421	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
323098000422	catalytic residues [active]
323098000423	transcription termination factor Rho; Provisional; Region: rho; PRK09376
323098000424	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
323098000425	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
323098000426	RNA binding site [nucleotide binding]; other site
323098000427	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
323098000428	multimer interface [polypeptide binding]; other site
323098000429	Walker A motif; other site
323098000430	ATP binding site [chemical binding]; other site
323098000431	Walker B motif; other site
323098000432	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
323098000433	PEP synthetase regulatory protein; Provisional; Region: PRK05339
323098000434	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
323098000435	active site
323098000436	dimer interface [polypeptide binding]; other site
323098000437	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
323098000438	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
323098000439	CoA-binding site [chemical binding]; other site
323098000440	ATP-binding [chemical binding]; other site
323098000441	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
323098000442	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
323098000443	active site
323098000444	catalytic site [active]
323098000445	substrate binding site [chemical binding]; other site
323098000446	preprotein translocase subunit SecB; Validated; Region: PRK05751
323098000447	SecA binding site; other site
323098000448	Preprotein binding site; other site
323098000449	Tim44-like domain; Region: Tim44; pfam04280
323098000450	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
323098000451	MltA specific insert domain; Region: MltA; smart00925
323098000452	3D domain; Region: 3D; pfam06725
323098000453	Smr domain; Region: Smr; pfam01713
323098000454	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
323098000455	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323098000456	dimer interface [polypeptide binding]; other site
323098000457	phosphorylation site [posttranslational modification]
323098000458	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323098000459	ATP binding site [chemical binding]; other site
323098000460	Mg2+ binding site [ion binding]; other site
323098000461	G-X-G motif; other site
323098000462	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
323098000463	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323098000464	active site
323098000465	phosphorylation site [posttranslational modification]
323098000466	intermolecular recognition site; other site
323098000467	dimerization interface [polypeptide binding]; other site
323098000468	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
323098000469	Protein of unknown function (DUF1052); Region: DUF1052; cl02197
323098000470	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
323098000471	PAS fold; Region: PAS_3; pfam08447
323098000472	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
323098000473	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323098000474	putative active site [active]
323098000475	PAS fold; Region: PAS_3; pfam08447
323098000476	heme pocket [chemical binding]; other site
323098000477	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323098000478	PAS domain; Region: PAS_9; pfam13426
323098000479	putative active site [active]
323098000480	heme pocket [chemical binding]; other site
323098000481	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323098000482	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
323098000483	dimer interface [polypeptide binding]; other site
323098000484	phosphorylation site [posttranslational modification]
323098000485	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323098000486	ATP binding site [chemical binding]; other site
323098000487	Mg2+ binding site [ion binding]; other site
323098000488	G-X-G motif; other site
323098000489	Response regulator receiver domain; Region: Response_reg; pfam00072
323098000490	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323098000491	active site
323098000492	phosphorylation site [posttranslational modification]
323098000493	intermolecular recognition site; other site
323098000494	dimerization interface [polypeptide binding]; other site
323098000495	Predicted methyltransferases [General function prediction only]; Region: COG0313
323098000496	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
323098000497	putative SAM binding site [chemical binding]; other site
323098000498	putative homodimer interface [polypeptide binding]; other site
323098000499	hypothetical protein; Reviewed; Region: PRK12497
323098000500	glutathione synthetase; Provisional; Region: PRK05246
323098000501	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
323098000502	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
323098000503	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
323098000504	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
323098000505	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
323098000506	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
323098000507	PAS domain S-box; Region: sensory_box; TIGR00229
323098000508	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323098000509	putative active site [active]
323098000510	heme pocket [chemical binding]; other site
323098000511	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323098000512	dimer interface [polypeptide binding]; other site
323098000513	phosphorylation site [posttranslational modification]
323098000514	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323098000515	ATP binding site [chemical binding]; other site
323098000516	Mg2+ binding site [ion binding]; other site
323098000517	G-X-G motif; other site
323098000518	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323098000519	active site
323098000520	phosphorylation site [posttranslational modification]
323098000521	intermolecular recognition site; other site
323098000522	dimerization interface [polypeptide binding]; other site
323098000523	Response regulator receiver domain; Region: Response_reg; pfam00072
323098000524	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323098000525	active site
323098000526	phosphorylation site [posttranslational modification]
323098000527	intermolecular recognition site; other site
323098000528	dimerization interface [polypeptide binding]; other site
323098000529	pantothenate kinase; Provisional; Region: PRK05439
323098000530	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
323098000531	ATP-binding site [chemical binding]; other site
323098000532	CoA-binding site [chemical binding]; other site
323098000533	Mg2+-binding site [ion binding]; other site
323098000534	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
323098000535	metal binding site [ion binding]; metal-binding site
323098000536	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
323098000537	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
323098000538	substrate binding site [chemical binding]; other site
323098000539	glutamase interaction surface [polypeptide binding]; other site
323098000540	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
323098000541	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
323098000542	catalytic residues [active]
323098000543	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
323098000544	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
323098000545	putative active site [active]
323098000546	oxyanion strand; other site
323098000547	catalytic triad [active]
323098000548	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
323098000549	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
323098000550	putative active site pocket [active]
323098000551	4-fold oligomerization interface [polypeptide binding]; other site
323098000552	metal binding residues [ion binding]; metal-binding site
323098000553	3-fold/trimer interface [polypeptide binding]; other site
323098000554	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
323098000555	active site
323098000556	HslU subunit interaction site [polypeptide binding]; other site
323098000557	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
323098000558	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
323098000559	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
323098000560	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
323098000561	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323098000562	Walker A motif; other site
323098000563	ATP binding site [chemical binding]; other site
323098000564	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323098000565	Walker B motif; other site
323098000566	arginine finger; other site
323098000567	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
323098000568	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
323098000569	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
323098000570	Protein of unknown function DUF45; Region: DUF45; pfam01863
323098000571	Transglycosylase; Region: Transgly; pfam00912
323098000572	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
323098000573	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
323098000574	PII uridylyl-transferase; Provisional; Region: PRK05092
323098000575	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
323098000576	metal binding triad; other site
323098000577	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
323098000578	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
323098000579	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
323098000580	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
323098000581	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
323098000582	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
323098000583	dimerization interface [polypeptide binding]; other site
323098000584	domain crossover interface; other site
323098000585	redox-dependent activation switch; other site
323098000586	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
323098000587	OpgC protein; Region: OpgC_C; pfam10129
323098000588	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
323098000589	active site
323098000590	oxyanion hole [active]
323098000591	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
323098000592	active site
323098000593	catalytic triad [active]
323098000594	oxyanion hole [active]
323098000595	O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504
323098000596	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
323098000597	homodimer interface [polypeptide binding]; other site
323098000598	substrate-cofactor binding pocket; other site
323098000599	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323098000600	catalytic residue [active]
323098000601	2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559
323098000602	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
323098000603	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
323098000604	trimer interface [polypeptide binding]; other site
323098000605	active site
323098000606	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
323098000607	camphor resistance protein CrcB; Provisional; Region: PRK14195
323098000608	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
323098000609	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
323098000610	Cu(I) binding site [ion binding]; other site
323098000611	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
323098000612	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
323098000613	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
323098000614	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
323098000615	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
323098000616	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
323098000617	active site
323098000618	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
323098000619	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
323098000620	substrate binding pocket [chemical binding]; other site
323098000621	membrane-bound complex binding site; other site
323098000622	hinge residues; other site
323098000623	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
323098000624	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
323098000625	active site
323098000626	nucleotide binding site [chemical binding]; other site
323098000627	HIGH motif; other site
323098000628	KMSKS motif; other site
323098000629	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
323098000630	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
323098000631	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
323098000632	active site
323098000633	Catalytic site; other site
323098000634	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
323098000635	Uncharacterized conserved small protein [Function unknown]; Region: COG5508
323098000636	Protein of unknown function (DUF1674); Region: DUF1674; pfam07896
323098000637	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
323098000638	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
323098000639	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323098000640	S-adenosylmethionine binding site [chemical binding]; other site
323098000641	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
323098000642	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
323098000643	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
323098000644	purine monophosphate binding site [chemical binding]; other site
323098000645	dimer interface [polypeptide binding]; other site
323098000646	putative catalytic residues [active]
323098000647	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
323098000648	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
323098000649	Cytochrome c; Region: Cytochrom_C; cl11414
323098000650	Cytochrome c553 [Energy production and conversion]; Region: COG2863
323098000651	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
323098000652	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
323098000653	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
323098000654	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
323098000655	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
323098000656	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
323098000657	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
323098000658	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
323098000659	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
323098000660	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
323098000661	GSH binding site (G-site) [chemical binding]; other site
323098000662	C-terminal domain interface [polypeptide binding]; other site
323098000663	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
323098000664	N-terminal domain interface [polypeptide binding]; other site
323098000665	dimer interface [polypeptide binding]; other site
323098000666	substrate binding pocket (H-site) [chemical binding]; other site
323098000667	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
323098000668	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
323098000669	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
323098000670	putative NAD(P) binding site [chemical binding]; other site
323098000671	active site
323098000672	Tetratricopeptide repeat; Region: TPR_12; pfam13424
323098000673	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
323098000674	binding surface
323098000675	TPR motif; other site
323098000676	Tetratricopeptide repeat; Region: TPR_12; pfam13424
323098000677	Tetratricopeptide repeat; Region: TPR_12; pfam13424
323098000678	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
323098000679	binding surface
323098000680	TPR motif; other site
323098000681	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
323098000682	putative metal binding site [ion binding]; other site
323098000683	Uncharacterized conserved protein [Function unknown]; Region: COG1432
323098000684	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
323098000685	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
323098000686	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
323098000687	catalytic site [active]
323098000688	putative active site [active]
323098000689	putative substrate binding site [chemical binding]; other site
323098000690	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
323098000691	OstA-like protein; Region: OstA; pfam03968
323098000692	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
323098000693	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
323098000694	Walker A/P-loop; other site
323098000695	ATP binding site [chemical binding]; other site
323098000696	Q-loop/lid; other site
323098000697	ABC transporter signature motif; other site
323098000698	Walker B; other site
323098000699	D-loop; other site
323098000700	H-loop/switch region; other site
323098000701	RNA polymerase factor sigma-54; Provisional; Region: PRK12469
323098000702	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
323098000703	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
323098000704	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
323098000705	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
323098000706	30S subunit binding site; other site
323098000707	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
323098000708	active site
323098000709	phosphorylation site [posttranslational modification]
323098000710	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323098000711	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
323098000712	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323098000713	glutamate--cysteine ligase; Region: PLN02611
323098000714	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
323098000715	Sel1-like repeats; Region: SEL1; smart00671
323098000716	Sel1-like repeats; Region: SEL1; smart00671
323098000717	Sel1 repeat; Region: Sel1; pfam08238
323098000718	Sel1-like repeats; Region: SEL1; smart00671
323098000719	Predicted permeases [General function prediction only]; Region: COG0730
323098000720	Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608
323098000721	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
323098000722	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
323098000723	putative active site [active]
323098000724	putative metal binding site [ion binding]; other site
323098000725	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
323098000726	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
323098000727	ATP binding site [chemical binding]; other site
323098000728	putative Mg++ binding site [ion binding]; other site
323098000729	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
323098000730	nucleotide binding region [chemical binding]; other site
323098000731	ATP-binding site [chemical binding]; other site
323098000732	DEAD/H associated; Region: DEAD_assoc; pfam08494
323098000733	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
323098000734	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
323098000735	heat shock protein HtpX; Provisional; Region: PRK01345
323098000736	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
323098000737	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
323098000738	putative ligand binding site [chemical binding]; other site
323098000739	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
323098000740	HemN C-terminal domain; Region: HemN_C; pfam06969
323098000741	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
323098000742	active site
323098000743	dimerization interface [polypeptide binding]; other site
323098000744	ribonuclease PH; Reviewed; Region: rph; PRK00173
323098000745	Ribonuclease PH; Region: RNase_PH_bact; cd11362
323098000746	hexamer interface [polypeptide binding]; other site
323098000747	active site
323098000748	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
323098000749	heat shock protein GrpE; Provisional; Region: PRK14141
323098000750	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
323098000751	dimer interface [polypeptide binding]; other site
323098000752	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
323098000753	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
323098000754	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
323098000755	nucleotide binding site [chemical binding]; other site
323098000756	NEF interaction site [polypeptide binding]; other site
323098000757	SBD interface [polypeptide binding]; other site
323098000758	chaperone protein DnaJ; Provisional; Region: PRK10767
323098000759	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
323098000760	HSP70 interaction site [polypeptide binding]; other site
323098000761	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
323098000762	substrate binding site [polypeptide binding]; other site
323098000763	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
323098000764	Zn binding sites [ion binding]; other site
323098000765	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
323098000766	dimer interface [polypeptide binding]; other site
323098000767	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323098000768	S-adenosylmethionine binding site [chemical binding]; other site
323098000769	Predicted flavoprotein [General function prediction only]; Region: COG0431
323098000770	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
323098000771	dihydrodipicolinate reductase; Provisional; Region: PRK00048
323098000772	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
323098000773	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
323098000774	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
323098000775	catalytic core [active]
323098000776	Helix-turn-helix domain; Region: HTH_18; pfam12833
323098000777	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
323098000778	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
323098000779	DNA binding site [nucleotide binding]
323098000780	active site
323098000781	Integral membrane protein (DUF2244); Region: DUF2244; pfam10003
323098000782	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
323098000783	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
323098000784	minor groove reading motif; other site
323098000785	helix-hairpin-helix signature motif; other site
323098000786	substrate binding pocket [chemical binding]; other site
323098000787	active site
323098000788	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
323098000789	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
323098000790	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
323098000791	RNA binding site [nucleotide binding]; other site
323098000792	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
323098000793	RNA binding site [nucleotide binding]; other site
323098000794	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
323098000795	RNA binding site [nucleotide binding]; other site
323098000796	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
323098000797	RNA binding site [nucleotide binding]; other site
323098000798	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
323098000799	RNA binding site [nucleotide binding]; other site
323098000800	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
323098000801	RNA binding site [nucleotide binding]; other site
323098000802	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
323098000803	cytidylate kinase; Provisional; Region: cmk; PRK00023
323098000804	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
323098000805	CMP-binding site; other site
323098000806	The sites determining sugar specificity; other site
323098000807	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
323098000808	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
323098000809	hinge; other site
323098000810	active site
323098000811	TIGR02300 family protein; Region: FYDLN_acid
323098000812	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
323098000813	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
323098000814	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
323098000815	putative dimer interface [polypeptide binding]; other site
323098000816	Protein of unknown function (DUF1150); Region: DUF1150; pfam06620
323098000817	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
323098000818	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323098000819	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
323098000820	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
323098000821	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
323098000822	active site
323098000823	HIGH motif; other site
323098000824	dimer interface [polypeptide binding]; other site
323098000825	KMSKS motif; other site
323098000826	integral membrane protein MviN; Region: mviN; TIGR01695
323098000827	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
323098000828	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
323098000829	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
323098000830	substrate binding site [chemical binding]; other site
323098000831	ATP binding site [chemical binding]; other site
323098000832	Pirin-related protein [General function prediction only]; Region: COG1741
323098000833	Pirin; Region: Pirin; pfam02678
323098000834	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
323098000835	protease TldD; Provisional; Region: tldD; PRK10735
323098000836	Invasion associated locus B (IalB) protein; Region: IalB; pfam06776
323098000837	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00051
323098000838	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
323098000839	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
323098000840	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
323098000841	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
323098000842	Subunit I/III interface [polypeptide binding]; other site
323098000843	D-pathway; other site
323098000844	Subunit I/VIIc interface [polypeptide binding]; other site
323098000845	Subunit I/IV interface [polypeptide binding]; other site
323098000846	Subunit I/II interface [polypeptide binding]; other site
323098000847	Low-spin heme (heme a) binding site [chemical binding]; other site
323098000848	Subunit I/VIIa interface [polypeptide binding]; other site
323098000849	Subunit I/VIa interface [polypeptide binding]; other site
323098000850	Dimer interface; other site
323098000851	Putative water exit pathway; other site
323098000852	Binuclear center (heme a3/CuB) [ion binding]; other site
323098000853	K-pathway; other site
323098000854	Subunit I/Vb interface [polypeptide binding]; other site
323098000855	Putative proton exit pathway; other site
323098000856	Subunit I/VIb interface; other site
323098000857	Subunit I/VIc interface [polypeptide binding]; other site
323098000858	Electron transfer pathway; other site
323098000859	Subunit I/VIIIb interface [polypeptide binding]; other site
323098000860	Subunit I/VIIb interface [polypeptide binding]; other site
323098000861	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
323098000862	UbiA prenyltransferase family; Region: UbiA; pfam01040
323098000863	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
323098000864	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
323098000865	Subunit III/VIIa interface [polypeptide binding]; other site
323098000866	Phospholipid binding site [chemical binding]; other site
323098000867	Subunit I/III interface [polypeptide binding]; other site
323098000868	Subunit III/VIb interface [polypeptide binding]; other site
323098000869	Subunit III/VIa interface; other site
323098000870	Subunit III/Vb interface [polypeptide binding]; other site
323098000871	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
323098000872	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
323098000873	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323098000874	catalytic residue [active]
323098000875	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
323098000876	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
323098000877	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
323098000878	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
323098000879	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
323098000880	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323098000881	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323098000882	Winged helix-turn helix; Region: HTH_29; pfam13551
323098000883	Homeodomain-like domain; Region: HTH_23; cl17451
323098000884	Homeodomain-like domain; Region: HTH_32; pfam13565
323098000885	F0F1 ATP synthase subunit B; Provisional; Region: PRK14475
323098000886	F0F1 ATP synthase subunit B; Validated; Region: PRK09173
323098000887	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
323098000888	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
323098000889	F0F1 ATP synthase subunit C; Validated; Region: PRK07558
323098000890	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
323098000891	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
323098000892	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336
323098000893	Septum formation initiator; Region: DivIC; cl17659
323098000894	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
323098000895	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323098000896	active site
323098000897	phosphorylation site [posttranslational modification]
323098000898	intermolecular recognition site; other site
323098000899	dimerization interface [polypeptide binding]; other site
323098000900	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
323098000901	DNA binding residues [nucleotide binding]
323098000902	dimerization interface [polypeptide binding]; other site
323098000903	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
323098000904	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
323098000905	substrate-cofactor binding pocket; other site
323098000906	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323098000907	catalytic residue [active]
323098000908	biotin synthase; Region: bioB; TIGR00433
323098000909	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
323098000910	FeS/SAM binding site; other site
323098000911	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
323098000912	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
323098000913	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
323098000914	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
323098000915	hinge; other site
323098000916	active site
323098000917	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
323098000918	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
323098000919	NAD binding site [chemical binding]; other site
323098000920	dimerization interface [polypeptide binding]; other site
323098000921	product binding site; other site
323098000922	substrate binding site [chemical binding]; other site
323098000923	zinc binding site [ion binding]; other site
323098000924	catalytic residues [active]
323098000925	hypothetical protein; Provisional; Region: PRK02853
323098000926	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
323098000927	Low molecular weight phosphatase family; Region: LMWPc; cd00115
323098000928	active site
323098000929	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
323098000930	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
323098000931	ATP binding site [chemical binding]; other site
323098000932	putative Mg++ binding site [ion binding]; other site
323098000933	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
323098000934	nucleotide binding region [chemical binding]; other site
323098000935	ATP-binding site [chemical binding]; other site
323098000936	Transcriptional regulator [Transcription]; Region: LysR; COG0583
323098000937	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
323098000938	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
323098000939	dimerization interface [polypeptide binding]; other site
323098000940	substrate binding pocket [chemical binding]; other site
323098000941	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
323098000942	ParB-like nuclease domain; Region: ParBc; pfam02195
323098000943	Helix-turn-helix domain; Region: HTH_28; pfam13518
323098000944	putative transposase OrfB; Reviewed; Region: PHA02517
323098000945	Homeodomain-like domain; Region: HTH_32; pfam13565
323098000946	Integrase core domain; Region: rve; pfam00665
323098000947	Integrase core domain; Region: rve_3; pfam13683
323098000948	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
323098000949	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
323098000950	TIR domain; Region: TIR_2; pfam13676
323098000951	HNH endonuclease; Region: HNH_5; pfam14279
323098000952	Domain of unknown function (DUF4365); Region: DUF4365; pfam14280
323098000953	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
323098000954	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
323098000955	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
323098000956	Domain of unknown function (DUF955); Region: DUF955; pfam06114
323098000957	AAA domain; Region: AAA_13; pfam13166
323098000958	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
323098000959	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
323098000960	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
323098000961	HsdM N-terminal domain; Region: HsdM_N; pfam12161
323098000962	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
323098000963	Methyltransferase domain; Region: Methyltransf_26; pfam13659
323098000964	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
323098000965	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
323098000966	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
323098000967	ATP binding site [chemical binding]; other site
323098000968	putative Mg++ binding site [ion binding]; other site
323098000969	Helix-turn-helix domain; Region: HTH_17; pfam12728
323098000970	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
323098000971	active site
323098000972	DNA binding site [nucleotide binding]
323098000973	Int/Topo IB signature motif; other site
323098000974	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
323098000975	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
323098000976	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
323098000977	zinc-binding protein; Provisional; Region: PRK01343
323098000978	Maf-like protein; Region: Maf; pfam02545
323098000979	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
323098000980	active site
323098000981	dimer interface [polypeptide binding]; other site
323098000982	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
323098000983	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
323098000984	dimer interface [polypeptide binding]; other site
323098000985	active site
323098000986	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
323098000987	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
323098000988	N- and C-terminal domain interface [polypeptide binding]; other site
323098000989	active site
323098000990	MgATP binding site [chemical binding]; other site
323098000991	catalytic site [active]
323098000992	metal binding site [ion binding]; metal-binding site
323098000993	glycerol binding site [chemical binding]; other site
323098000994	homotetramer interface [polypeptide binding]; other site
323098000995	homodimer interface [polypeptide binding]; other site
323098000996	FBP binding site [chemical binding]; other site
323098000997	protein IIAGlc interface [polypeptide binding]; other site
323098000998	PAS domain; Region: PAS_9; pfam13426
323098000999	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323098001000	putative active site [active]
323098001001	heme pocket [chemical binding]; other site
323098001002	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
323098001003	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
323098001004	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
323098001005	substrate binding pocket [chemical binding]; other site
323098001006	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
323098001007	B12 binding site [chemical binding]; other site
323098001008	cobalt ligand [ion binding]; other site
323098001009	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
323098001010	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
323098001011	FAD binding site [chemical binding]; other site
323098001012	prephenate dehydratase; Provisional; Region: PRK11899
323098001013	Prephenate dehydratase; Region: PDT; pfam00800
323098001014	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
323098001015	putative L-Phe binding site [chemical binding]; other site
323098001016	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
323098001017	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
323098001018	Ligand binding site; other site
323098001019	oligomer interface; other site
323098001020	Cytochrome c2 [Energy production and conversion]; Region: COG3474
323098001021	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
323098001022	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
323098001023	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
323098001024	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
323098001025	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
323098001026	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
323098001027	dimer interface [polypeptide binding]; other site
323098001028	conserved gate region; other site
323098001029	putative PBP binding loops; other site
323098001030	ABC-ATPase subunit interface; other site
323098001031	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
323098001032	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
323098001033	dimer interface [polypeptide binding]; other site
323098001034	conserved gate region; other site
323098001035	ABC-ATPase subunit interface; other site
323098001036	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
323098001037	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
323098001038	Walker A/P-loop; other site
323098001039	ATP binding site [chemical binding]; other site
323098001040	Q-loop/lid; other site
323098001041	ABC transporter signature motif; other site
323098001042	Walker B; other site
323098001043	D-loop; other site
323098001044	H-loop/switch region; other site
323098001045	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
323098001046	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
323098001047	Walker A/P-loop; other site
323098001048	ATP binding site [chemical binding]; other site
323098001049	Q-loop/lid; other site
323098001050	ABC transporter signature motif; other site
323098001051	Walker B; other site
323098001052	D-loop; other site
323098001053	H-loop/switch region; other site
323098001054	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
323098001055	Src Homology 3 domain superfamily; Region: SH3; cl17036
323098001056	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
323098001057	NlpC/P60 family; Region: NLPC_P60; pfam00877
323098001058	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
323098001059	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
323098001060	interface (dimer of trimers) [polypeptide binding]; other site
323098001061	Substrate-binding/catalytic site; other site
323098001062	Zn-binding sites [ion binding]; other site
323098001063	Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010
323098001064	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
323098001065	binding surface
323098001066	TPR motif; other site
323098001067	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
323098001068	TPR motif; other site
323098001069	binding surface
323098001070	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
323098001071	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
323098001072	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
323098001073	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
323098001074	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
323098001075	ATP binding site [chemical binding]; other site
323098001076	Walker A motif; other site
323098001077	hexamer interface [polypeptide binding]; other site
323098001078	Walker B motif; other site
323098001079	Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
323098001080	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
323098001081	Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476
323098001082	Type IV pili component [Cell motility and secretion]; Region: COG5461
323098001083	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
323098001084	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
323098001085	BON domain; Region: BON; pfam04972
323098001086	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
323098001087	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
323098001088	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
323098001089	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
323098001090	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
323098001091	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
323098001092	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
323098001093	TadE-like protein; Region: TadE; pfam07811
323098001094	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
323098001095	TadE-like protein; Region: TadE; pfam07811
323098001096	Winged helix-turn helix; Region: HTH_29; pfam13551
323098001097	Integrase core domain; Region: rve; pfam00665
323098001098	Integrase core domain; Region: rve_3; pfam13683
323098001099	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323098001100	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323098001101	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
323098001102	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
323098001103	DNA-binding site [nucleotide binding]; DNA binding site
323098001104	RNA-binding motif; other site
323098001105	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
323098001106	rRNA binding site [nucleotide binding]; other site
323098001107	predicted 30S ribosome binding site; other site
323098001108	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
323098001109	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
323098001110	ATP binding site [chemical binding]; other site
323098001111	Mg++ binding site [ion binding]; other site
323098001112	motif III; other site
323098001113	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
323098001114	nucleotide binding region [chemical binding]; other site
323098001115	ATP-binding site [chemical binding]; other site
323098001116	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
323098001117	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
323098001118	active site
323098001119	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
323098001120	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
323098001121	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
323098001122	P loop; other site
323098001123	GTP binding site [chemical binding]; other site
323098001124	intracellular septation protein A; Reviewed; Region: PRK00259
323098001125	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
323098001126	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
323098001127	catalytic residues [active]
323098001128	central insert; other site
323098001129	heme exporter protein CcmC; Region: ccmC; TIGR01191
323098001130	heme exporter protein CcmB; Region: ccmB; TIGR01190
323098001131	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
323098001132	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
323098001133	Walker A/P-loop; other site
323098001134	ATP binding site [chemical binding]; other site
323098001135	Q-loop/lid; other site
323098001136	ABC transporter signature motif; other site
323098001137	Walker B; other site
323098001138	D-loop; other site
323098001139	H-loop/switch region; other site
323098001140	aconitate hydratase; Validated; Region: PRK09277
323098001141	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
323098001142	substrate binding site [chemical binding]; other site
323098001143	ligand binding site [chemical binding]; other site
323098001144	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
323098001145	substrate binding site [chemical binding]; other site
323098001146	Protein of unknown function (DUF1223); Region: DUF1223; pfam06764
323098001147	Protein of unknown function (DUF2794); Region: DUF2794; pfam10984
323098001148	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
323098001149	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
323098001150	putative ADP-binding pocket [chemical binding]; other site
323098001151	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
323098001152	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
323098001153	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
323098001154	Walker A/P-loop; other site
323098001155	ATP binding site [chemical binding]; other site
323098001156	Q-loop/lid; other site
323098001157	ABC transporter signature motif; other site
323098001158	Walker B; other site
323098001159	D-loop; other site
323098001160	H-loop/switch region; other site
323098001161	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
323098001162	Protein of unknown function, DUF608; Region: DUF608; pfam04685
323098001163	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
323098001164	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
323098001165	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
323098001166	Creatinine amidohydrolase; Region: Creatininase; pfam02633
323098001167	NMT1/THI5 like; Region: NMT1; pfam09084
323098001168	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
323098001169	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
323098001170	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
323098001171	Walker A/P-loop; other site
323098001172	ATP binding site [chemical binding]; other site
323098001173	Q-loop/lid; other site
323098001174	ABC transporter signature motif; other site
323098001175	Walker B; other site
323098001176	D-loop; other site
323098001177	H-loop/switch region; other site
323098001178	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
323098001179	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
323098001180	hypothetical protein; Reviewed; Region: PRK00024
323098001181	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
323098001182	MPN+ (JAMM) motif; other site
323098001183	Zinc-binding site [ion binding]; other site
323098001184	methionine aminopeptidase; Provisional; Region: PRK12318
323098001185	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
323098001186	active site
323098001187	potassium/proton antiporter; Reviewed; Region: PRK05326
323098001188	Transporter associated domain; Region: CorC_HlyC; smart01091
323098001189	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
323098001190	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
323098001191	Walker A/P-loop; other site
323098001192	ATP binding site [chemical binding]; other site
323098001193	Q-loop/lid; other site
323098001194	ABC transporter signature motif; other site
323098001195	Walker B; other site
323098001196	D-loop; other site
323098001197	H-loop/switch region; other site
323098001198	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
323098001199	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
323098001200	dimer interface [polypeptide binding]; other site
323098001201	conserved gate region; other site
323098001202	putative PBP binding loops; other site
323098001203	ABC-ATPase subunit interface; other site
323098001204	molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677
323098001205	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
323098001206	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
323098001207	GTP-binding protein LepA; Provisional; Region: PRK05433
323098001208	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
323098001209	G1 box; other site
323098001210	putative GEF interaction site [polypeptide binding]; other site
323098001211	GTP/Mg2+ binding site [chemical binding]; other site
323098001212	Switch I region; other site
323098001213	G2 box; other site
323098001214	G3 box; other site
323098001215	Switch II region; other site
323098001216	G4 box; other site
323098001217	G5 box; other site
323098001218	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
323098001219	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
323098001220	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
323098001221	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
323098001222	regulatory protein interface [polypeptide binding]; other site
323098001223	active site
323098001224	regulatory phosphorylation site [posttranslational modification]; other site
323098001225	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
323098001226	active pocket/dimerization site; other site
323098001227	active site
323098001228	phosphorylation site [posttranslational modification]
323098001229	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
323098001230	Hpr binding site; other site
323098001231	active site
323098001232	homohexamer subunit interaction site [polypeptide binding]; other site
323098001233	Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755
323098001234	Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756
323098001235	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
323098001236	HAMP domain; Region: HAMP; pfam00672
323098001237	dimerization interface [polypeptide binding]; other site
323098001238	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323098001239	dimer interface [polypeptide binding]; other site
323098001240	phosphorylation site [posttranslational modification]
323098001241	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323098001242	ATP binding site [chemical binding]; other site
323098001243	Mg2+ binding site [ion binding]; other site
323098001244	G-X-G motif; other site
323098001245	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
323098001246	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323098001247	active site
323098001248	phosphorylation site [posttranslational modification]
323098001249	intermolecular recognition site; other site
323098001250	dimerization interface [polypeptide binding]; other site
323098001251	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
323098001252	DNA binding site [nucleotide binding]
323098001253	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
323098001254	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
323098001255	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
323098001256	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
323098001257	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
323098001258	active site
323098001259	substrate-binding site [chemical binding]; other site
323098001260	metal-binding site [ion binding]
323098001261	ATP binding site [chemical binding]; other site
323098001262	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
323098001263	Arginase family; Region: Arginase; cd09989
323098001264	agmatinase; Region: agmatinase; TIGR01230
323098001265	active site
323098001266	Mn binding site [ion binding]; other site
323098001267	oligomer interface [polypeptide binding]; other site
323098001268	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
323098001269	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
323098001270	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
323098001271	active site
323098001272	DNA binding site [nucleotide binding]
323098001273	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
323098001274	DNA binding site [nucleotide binding]
323098001275	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
323098001276	nucleotide binding site [chemical binding]; other site
323098001277	Ku-homolog [Replication, recombination, and repair]; Region: COG1273
323098001278	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
323098001279	putative DNA binding site [nucleotide binding]; other site
323098001280	putative homodimer interface [polypeptide binding]; other site
323098001281	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
323098001282	5'-3' exonuclease; Region: 53EXOc; smart00475
323098001283	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
323098001284	active site
323098001285	metal binding site 1 [ion binding]; metal-binding site
323098001286	putative 5' ssDNA interaction site; other site
323098001287	metal binding site 3; metal-binding site
323098001288	metal binding site 2 [ion binding]; metal-binding site
323098001289	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
323098001290	putative DNA binding site [nucleotide binding]; other site
323098001291	putative metal binding site [ion binding]; other site
323098001292	DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749
323098001293	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
323098001294	active site
323098001295	catalytic site [active]
323098001296	substrate binding site [chemical binding]; other site
323098001297	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
323098001298	active site
323098001299	DNA binding site [nucleotide binding]
323098001300	catalytic site [active]
323098001301	Predicted membrane protein [Function unknown]; Region: COG4763
323098001302	Acyltransferase family; Region: Acyl_transf_3; pfam01757
323098001303	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
323098001304	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
323098001305	ATP binding site [chemical binding]; other site
323098001306	putative Mg++ binding site [ion binding]; other site
323098001307	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
323098001308	nucleotide binding region [chemical binding]; other site
323098001309	ATP-binding site [chemical binding]; other site
323098001310	Helicase associated domain (HA2); Region: HA2; pfam04408
323098001311	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
323098001312	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
323098001313	catalytic motif [active]
323098001314	Catalytic residue [active]
323098001315	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
323098001316	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
323098001317	active site
323098001318	substrate binding site [chemical binding]; other site
323098001319	metal binding site [ion binding]; metal-binding site
323098001320	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
323098001321	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
323098001322	putative DNA binding site [nucleotide binding]; other site
323098001323	putative Zn2+ binding site [ion binding]; other site
323098001324	AsnC family; Region: AsnC_trans_reg; pfam01037
323098001325	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323098001326	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323098001327	Homeodomain-like domain; Region: HTH_23; cl17451
323098001328	Winged helix-turn helix; Region: HTH_29; pfam13551
323098001329	Homeodomain-like domain; Region: HTH_32; pfam13565
323098001330	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323098001331	Winged helix-turn helix; Region: HTH_29; pfam13551
323098001332	Integrase core domain; Region: rve; pfam00665
323098001333	Integrase core domain; Region: rve_3; pfam13683
323098001334	recombination protein RecR; Reviewed; Region: recR; PRK00076
323098001335	RecR protein; Region: RecR; pfam02132
323098001336	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
323098001337	tetramer interface [polypeptide binding]; other site
323098001338	putative active site [active]
323098001339	putative metal-binding site [ion binding]; other site
323098001340	hypothetical protein; Validated; Region: PRK00153
323098001341	DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111
323098001342	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323098001343	Walker A motif; other site
323098001344	ATP binding site [chemical binding]; other site
323098001345	Walker B motif; other site
323098001346	arginine finger; other site
323098001347	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
323098001348	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
323098001349	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
323098001350	HIT family signature motif; other site
323098001351	catalytic residue [active]
323098001352	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
323098001353	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
323098001354	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
323098001355	Methyltransferase domain; Region: Methyltransf_23; pfam13489
323098001356	Methyltransferase domain; Region: Methyltransf_11; pfam08241
323098001357	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
323098001358	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
323098001359	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323098001360	S-adenosylmethionine binding site [chemical binding]; other site
323098001361	peptide chain release factor 1; Validated; Region: prfA; PRK00591
323098001362	This domain is found in peptide chain release factors; Region: PCRF; smart00937
323098001363	RF-1 domain; Region: RF-1; pfam00472
323098001364	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
323098001365	GAF domain; Region: GAF; pfam01590
323098001366	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
323098001367	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
323098001368	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
323098001369	aspartate kinase; Reviewed; Region: PRK06635
323098001370	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
323098001371	putative nucleotide binding site [chemical binding]; other site
323098001372	putative catalytic residues [active]
323098001373	putative Mg ion binding site [ion binding]; other site
323098001374	putative aspartate binding site [chemical binding]; other site
323098001375	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
323098001376	putative allosteric regulatory site; other site
323098001377	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
323098001378	putative allosteric regulatory residue; other site
323098001379	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
323098001380	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323098001381	S-adenosylmethionine binding site [chemical binding]; other site
323098001382	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
323098001383	Protein of unknown function (DUF1178); Region: DUF1178; cl17833
323098001384	nitrilase; Region: PLN02798
323098001385	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
323098001386	putative active site [active]
323098001387	catalytic triad [active]
323098001388	dimer interface [polypeptide binding]; other site
323098001389	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
323098001390	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
323098001391	active site
323098001392	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
323098001393	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
323098001394	active site
323098001395	8-oxo-dGMP binding site [chemical binding]; other site
323098001396	nudix motif; other site
323098001397	metal binding site [ion binding]; metal-binding site
323098001398	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
323098001399	heterotetramer interface [polypeptide binding]; other site
323098001400	active site pocket [active]
323098001401	cleavage site
323098001402	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
323098001403	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
323098001404	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
323098001405	SEC-C motif; Region: SEC-C; pfam02810
323098001406	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
323098001407	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
323098001408	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; pfam03255
323098001409	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
323098001410	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
323098001411	active site
323098001412	DNA binding site [nucleotide binding]
323098001413	Int/Topo IB signature motif; other site
323098001414	shikimate kinase; Provisional; Region: PRK13946
323098001415	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
323098001416	ADP binding site [chemical binding]; other site
323098001417	magnesium binding site [ion binding]; other site
323098001418	putative shikimate binding site; other site
323098001419	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
323098001420	active site
323098001421	dimer interface [polypeptide binding]; other site
323098001422	metal binding site [ion binding]; metal-binding site
323098001423	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
323098001424	Domain of unknown function DUF21; Region: DUF21; pfam01595
323098001425	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
323098001426	Transporter associated domain; Region: CorC_HlyC; smart01091
323098001427	PilZ domain; Region: PilZ; pfam07238
323098001428	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
323098001429	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
323098001430	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
323098001431	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
323098001432	HSP70 interaction site [polypeptide binding]; other site
323098001433	Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865
323098001434	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
323098001435	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
323098001436	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
323098001437	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
323098001438	cobaltochelatase, CobT subunit; Region: CobT; TIGR01651
323098001439	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
323098001440	metal ion-dependent adhesion site (MIDAS); other site
323098001441	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246
323098001442	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
323098001443	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
323098001444	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
323098001445	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
323098001446	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323098001447	Walker A motif; other site
323098001448	ATP binding site [chemical binding]; other site
323098001449	Walker B motif; other site
323098001450	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
323098001451	nucleotide binding region [chemical binding]; other site
323098001452	ATP-binding site [chemical binding]; other site
323098001453	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
323098001454	RNA binding surface [nucleotide binding]; other site
323098001455	Ferredoxin [Energy production and conversion]; Region: COG1146
323098001456	4Fe-4S binding domain; Region: Fer4; cl02805
323098001457	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
323098001458	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
323098001459	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
323098001460	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
323098001461	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
323098001462	FtsX-like permease family; Region: FtsX; pfam02687
323098001463	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
323098001464	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
323098001465	Walker A/P-loop; other site
323098001466	ATP binding site [chemical binding]; other site
323098001467	Q-loop/lid; other site
323098001468	ABC transporter signature motif; other site
323098001469	Walker B; other site
323098001470	D-loop; other site
323098001471	H-loop/switch region; other site
323098001472	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
323098001473	active site
323098001474	catalytic triad [active]
323098001475	oxyanion hole [active]
323098001476	switch loop; other site
323098001477	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
323098001478	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
323098001479	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
323098001480	Predicted ATPase [General function prediction only]; Region: COG1485
323098001481	AAA ATPase domain; Region: AAA_16; pfam13191
323098001482	malate dehydrogenase; Reviewed; Region: PRK06223
323098001483	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
323098001484	NAD(P) binding site [chemical binding]; other site
323098001485	dimer interface [polypeptide binding]; other site
323098001486	tetramer (dimer of dimers) interface [polypeptide binding]; other site
323098001487	substrate binding site [chemical binding]; other site
323098001488	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
323098001489	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
323098001490	CoA-ligase; Region: Ligase_CoA; pfam00549
323098001491	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
323098001492	CoA binding domain; Region: CoA_binding; smart00881
323098001493	CoA-ligase; Region: Ligase_CoA; pfam00549
323098001494	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
323098001495	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
323098001496	TPP-binding site [chemical binding]; other site
323098001497	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
323098001498	dimer interface [polypeptide binding]; other site
323098001499	PYR/PP interface [polypeptide binding]; other site
323098001500	TPP binding site [chemical binding]; other site
323098001501	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
323098001502	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
323098001503	E3 interaction surface; other site
323098001504	lipoyl attachment site [posttranslational modification]; other site
323098001505	e3 binding domain; Region: E3_binding; pfam02817
323098001506	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
323098001507	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06115
323098001508	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
323098001509	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
323098001510	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
323098001511	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
323098001512	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
323098001513	active site
323098001514	DNA binding site [nucleotide binding]
323098001515	Int/Topo IB signature motif; other site
323098001516	primosome assembly protein PriA; Validated; Region: PRK05580
323098001517	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
323098001518	ATP binding site [chemical binding]; other site
323098001519	putative Mg++ binding site [ion binding]; other site
323098001520	helicase superfamily c-terminal domain; Region: HELICc; smart00490
323098001521	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
323098001522	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
323098001523	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
323098001524	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
323098001525	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
323098001526	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
323098001527	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
323098001528	beta subunit interaction interface [polypeptide binding]; other site
323098001529	Walker A motif; other site
323098001530	ATP binding site [chemical binding]; other site
323098001531	Walker B motif; other site
323098001532	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
323098001533	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
323098001534	core domain interface [polypeptide binding]; other site
323098001535	delta subunit interface [polypeptide binding]; other site
323098001536	epsilon subunit interface [polypeptide binding]; other site
323098001537	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
323098001538	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
323098001539	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
323098001540	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
323098001541	alpha subunit interaction interface [polypeptide binding]; other site
323098001542	Walker A motif; other site
323098001543	ATP binding site [chemical binding]; other site
323098001544	Walker B motif; other site
323098001545	inhibitor binding site; inhibition site
323098001546	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
323098001547	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13448
323098001548	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
323098001549	gamma subunit interface [polypeptide binding]; other site
323098001550	epsilon subunit interface [polypeptide binding]; other site
323098001551	LBP interface [polypeptide binding]; other site
323098001552	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323098001553	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
323098001554	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
323098001555	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
323098001556	nucleotide binding site [chemical binding]; other site
323098001557	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
323098001558	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
323098001559	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
323098001560	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
323098001561	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
323098001562	Coenzyme A binding pocket [chemical binding]; other site
323098001563	GTPase CgtA; Reviewed; Region: obgE; PRK12299
323098001564	GTP1/OBG; Region: GTP1_OBG; pfam01018
323098001565	Obg GTPase; Region: Obg; cd01898
323098001566	G1 box; other site
323098001567	GTP/Mg2+ binding site [chemical binding]; other site
323098001568	Switch I region; other site
323098001569	G2 box; other site
323098001570	G3 box; other site
323098001571	Switch II region; other site
323098001572	G4 box; other site
323098001573	G5 box; other site
323098001574	gamma-glutamyl kinase; Provisional; Region: PRK05429
323098001575	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
323098001576	nucleotide binding site [chemical binding]; other site
323098001577	homotetrameric interface [polypeptide binding]; other site
323098001578	putative phosphate binding site [ion binding]; other site
323098001579	putative allosteric binding site; other site
323098001580	PUA domain; Region: PUA; pfam01472
323098001581	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
323098001582	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
323098001583	putative catalytic cysteine [active]
323098001584	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
323098001585	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
323098001586	active site
323098001587	(T/H)XGH motif; other site
323098001588	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
323098001589	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
323098001590	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
323098001591	Peptidase family M23; Region: Peptidase_M23; pfam01551
323098001592	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
323098001593	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
323098001594	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
323098001595	protein binding site [polypeptide binding]; other site
323098001596	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
323098001597	Catalytic dyad [active]
323098001598	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
323098001599	putative active site [active]
323098001600	NodB motif; other site
323098001601	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
323098001602	putative active site [active]
323098001603	Ap4A binding site [chemical binding]; other site
323098001604	nudix motif; other site
323098001605	putative metal binding site [ion binding]; other site
323098001606	Putative Zn-dependent protease [General function prediction only]; Region: COG4784
323098001607	Peptidase family M48; Region: Peptidase_M48; pfam01435
323098001608	Staphylococcal nuclease homologues; Region: SNc; smart00318
323098001609	Predicted membrane protein [Function unknown]; Region: COG2261
323098001610	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
323098001611	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
323098001612	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
323098001613	dimer interface [polypeptide binding]; other site
323098001614	conserved gate region; other site
323098001615	putative PBP binding loops; other site
323098001616	ABC-ATPase subunit interface; other site
323098001617	NMT1-like family; Region: NMT1_2; pfam13379
323098001618	NMT1/THI5 like; Region: NMT1; pfam09084
323098001619	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
323098001620	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
323098001621	Walker A/P-loop; other site
323098001622	ATP binding site [chemical binding]; other site
323098001623	Q-loop/lid; other site
323098001624	ABC transporter signature motif; other site
323098001625	Walker B; other site
323098001626	D-loop; other site
323098001627	H-loop/switch region; other site
323098001628	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
323098001629	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
323098001630	active site
323098001631	Uncharacterized conserved protein [Function unknown]; Region: COG2128
323098001632	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
323098001633	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
323098001634	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
323098001635	ATP-dependent DNA ligase; Validated; Region: PRK09247
323098001636	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
323098001637	active site
323098001638	DNA binding site [nucleotide binding]
323098001639	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
323098001640	DNA binding site [nucleotide binding]
323098001641	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
323098001642	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
323098001643	quinone interaction residues [chemical binding]; other site
323098001644	active site
323098001645	catalytic residues [active]
323098001646	FMN binding site [chemical binding]; other site
323098001647	substrate binding site [chemical binding]; other site
323098001648	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502
323098001649	Predicted transcriptional regulator [Transcription]; Region: COG2932
323098001650	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
323098001651	Catalytic site [active]
323098001652	acetyl-CoA synthetase; Provisional; Region: PRK00174
323098001653	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
323098001654	active site
323098001655	CoA binding site [chemical binding]; other site
323098001656	acyl-activating enzyme (AAE) consensus motif; other site
323098001657	AMP binding site [chemical binding]; other site
323098001658	acetate binding site [chemical binding]; other site
323098001659	EVE domain; Region: EVE; pfam01878
323098001660	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
323098001661	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
323098001662	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
323098001663	UGMP family protein; Validated; Region: PRK09604
323098001664	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
323098001665	Porphobilinogen deaminase [Coenzyme metabolism]; Region: HemC; COG0181
323098001666	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
323098001667	domain interfaces; other site
323098001668	active site
323098001669	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
323098001670	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
323098001671	active site
323098001672	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223
323098001673	Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898
323098001674	tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313
323098001675	putative metal binding site [ion binding]; other site
323098001676	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
323098001677	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323098001678	NAD(P) binding site [chemical binding]; other site
323098001679	active site
323098001680	YGGT family; Region: YGGT; pfam02325
323098001681	hypothetical protein; Validated; Region: PRK01310
323098001682	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
323098001683	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
323098001684	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
323098001685	homodimer interface [polypeptide binding]; other site
323098001686	NADP binding site [chemical binding]; other site
323098001687	substrate binding site [chemical binding]; other site
323098001688	Winged helix-turn helix; Region: HTH_29; pfam13551
323098001689	Integrase core domain; Region: rve; pfam00665
323098001690	Integrase core domain; Region: rve_3; pfam13683
323098001691	Winged helix-turn helix; Region: HTH_29; pfam13551
323098001692	Homeodomain-like domain; Region: HTH_23; cl17451
323098001693	Homeodomain-like domain; Region: HTH_32; pfam13565
323098001694	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323098001695	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323098001696	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
323098001697	dimer interface [polypeptide binding]; other site
323098001698	substrate binding site [chemical binding]; other site
323098001699	metal binding sites [ion binding]; metal-binding site
323098001700	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
323098001701	short chain dehydrogenase; Provisional; Region: PRK12744
323098001702	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323098001703	NAD(P) binding site [chemical binding]; other site
323098001704	active site
323098001705	Transcriptional regulator [Transcription]; Region: LysR; COG0583
323098001706	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
323098001707	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
323098001708	putative effector binding pocket; other site
323098001709	putative dimerization interface [polypeptide binding]; other site
323098001710	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
323098001711	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
323098001712	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
323098001713	MutS domain I; Region: MutS_I; pfam01624
323098001714	MutS domain II; Region: MutS_II; pfam05188
323098001715	MutS domain III; Region: MutS_III; pfam05192
323098001716	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
323098001717	Walker A/P-loop; other site
323098001718	ATP binding site [chemical binding]; other site
323098001719	Q-loop/lid; other site
323098001720	ABC transporter signature motif; other site
323098001721	Walker B; other site
323098001722	D-loop; other site
323098001723	H-loop/switch region; other site
323098001724	Methyltransferase domain; Region: Methyltransf_31; pfam13847
323098001725	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323098001726	S-adenosylmethionine binding site [chemical binding]; other site
323098001727	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
323098001728	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
323098001729	metal binding site 2 [ion binding]; metal-binding site
323098001730	putative DNA binding helix; other site
323098001731	metal binding site 1 [ion binding]; metal-binding site
323098001732	dimer interface [polypeptide binding]; other site
323098001733	structural Zn2+ binding site [ion binding]; other site
323098001734	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
323098001735	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
323098001736	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
323098001737	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
323098001738	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
323098001739	substrate binding pocket [chemical binding]; other site
323098001740	chain length determination region; other site
323098001741	substrate-Mg2+ binding site; other site
323098001742	catalytic residues [active]
323098001743	aspartate-rich region 1; other site
323098001744	active site lid residues [active]
323098001745	aspartate-rich region 2; other site
323098001746	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
323098001747	Transglycosylase; Region: Transgly; cl17702
323098001748	Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333
323098001749	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
323098001750	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
323098001751	metal binding site [ion binding]; metal-binding site
323098001752	active site
323098001753	I-site; other site
323098001754	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
323098001755	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
323098001756	Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968
323098001757	putative active site [active]
323098001758	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
323098001759	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
323098001760	ligand binding site [chemical binding]; other site
323098001761	Predicted integral membrane protein [Function unknown]; Region: COG0392
323098001762	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
323098001763	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323098001764	dimer interface [polypeptide binding]; other site
323098001765	phosphorylation site [posttranslational modification]
323098001766	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323098001767	ATP binding site [chemical binding]; other site
323098001768	Mg2+ binding site [ion binding]; other site
323098001769	G-X-G motif; other site
323098001770	PBP superfamily domain; Region: PBP_like_2; cl17296
323098001771	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
323098001772	dimer interface [polypeptide binding]; other site
323098001773	conserved gate region; other site
323098001774	putative PBP binding loops; other site
323098001775	ABC-ATPase subunit interface; other site
323098001776	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
323098001777	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
323098001778	dimer interface [polypeptide binding]; other site
323098001779	conserved gate region; other site
323098001780	putative PBP binding loops; other site
323098001781	ABC-ATPase subunit interface; other site
323098001782	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
323098001783	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
323098001784	Walker A/P-loop; other site
323098001785	ATP binding site [chemical binding]; other site
323098001786	Q-loop/lid; other site
323098001787	ABC transporter signature motif; other site
323098001788	Walker B; other site
323098001789	D-loop; other site
323098001790	H-loop/switch region; other site
323098001791	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
323098001792	PhoU domain; Region: PhoU; pfam01895
323098001793	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
323098001794	PhoU domain; Region: PhoU; pfam01895
323098001795	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
323098001796	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323098001797	active site
323098001798	phosphorylation site [posttranslational modification]
323098001799	intermolecular recognition site; other site
323098001800	dimerization interface [polypeptide binding]; other site
323098001801	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
323098001802	DNA binding site [nucleotide binding]
323098001803	GcrA cell cycle regulator; Region: GcrA; pfam07750
323098001804	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
323098001805	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
323098001806	inhibitor-cofactor binding pocket; inhibition site
323098001807	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323098001808	catalytic residue [active]
323098001809	ornithine carbamoyltransferase; Provisional; Region: PRK00779
323098001810	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
323098001811	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
323098001812	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
323098001813	Protein of unknown function (DUF1134); Region: DUF1134; pfam06577
323098001814	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
323098001815	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
323098001816	active site
323098001817	Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090
323098001818	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
323098001819	putative binding surface; other site
323098001820	active site
323098001821	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
323098001822	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
323098001823	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323098001824	ATP binding site [chemical binding]; other site
323098001825	Mg2+ binding site [ion binding]; other site
323098001826	G-X-G motif; other site
323098001827	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
323098001828	CheW-like domain; Region: CheW; pfam01584
323098001829	Response regulator receiver domain; Region: Response_reg; pfam00072
323098001830	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323098001831	active site
323098001832	phosphorylation site [posttranslational modification]
323098001833	intermolecular recognition site; other site
323098001834	dimerization interface [polypeptide binding]; other site
323098001835	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
323098001836	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323098001837	Response regulator receiver domain; Region: Response_reg; pfam00072
323098001838	active site
323098001839	phosphorylation site [posttranslational modification]
323098001840	intermolecular recognition site; other site
323098001841	dimerization interface [polypeptide binding]; other site
323098001842	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
323098001843	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323098001844	active site
323098001845	phosphorylation site [posttranslational modification]
323098001846	intermolecular recognition site; other site
323098001847	dimerization interface [polypeptide binding]; other site
323098001848	CheB methylesterase; Region: CheB_methylest; pfam01339
323098001849	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
323098001850	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
323098001851	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
323098001852	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
323098001853	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323098001854	active site
323098001855	phosphorylation site [posttranslational modification]
323098001856	intermolecular recognition site; other site
323098001857	dimerization interface [polypeptide binding]; other site
323098001858	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
323098001859	DNA binding site [nucleotide binding]
323098001860	flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927
323098001861	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
323098001862	Walker A motif/ATP binding site; other site
323098001863	Walker B motif; other site
323098001864	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
323098001865	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
323098001866	FHIPEP family; Region: FHIPEP; pfam00771
323098001867	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323098001868	PAS domain; Region: PAS_9; pfam13426
323098001869	putative active site [active]
323098001870	heme pocket [chemical binding]; other site
323098001871	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
323098001872	dimer interface [polypeptide binding]; other site
323098001873	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
323098001874	putative CheW interface [polypeptide binding]; other site
323098001875	Homeodomain-like domain; Region: HTH_23; cl17451
323098001876	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
323098001877	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
323098001878	P-loop; other site
323098001879	Magnesium ion binding site [ion binding]; other site
323098001880	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
323098001881	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
323098001882	Methyltransferase domain; Region: Methyltransf_23; pfam13489
323098001883	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323098001884	S-adenosylmethionine binding site [chemical binding]; other site
323098001885	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
323098001886	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
323098001887	putative active site [active]
323098001888	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
323098001889	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
323098001890	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
323098001891	Walker A/P-loop; other site
323098001892	ATP binding site [chemical binding]; other site
323098001893	Q-loop/lid; other site
323098001894	ABC transporter signature motif; other site
323098001895	Walker B; other site
323098001896	D-loop; other site
323098001897	H-loop/switch region; other site
323098001898	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
323098001899	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
323098001900	HlyD family secretion protein; Region: HlyD_3; pfam13437
323098001901	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
323098001902	Sel1-like repeats; Region: SEL1; smart00671
323098001903	Sel1-like repeats; Region: SEL1; smart00671
323098001904	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
323098001905	Sel1-like repeats; Region: SEL1; smart00671
323098001906	Sel1-like repeats; Region: SEL1; smart00671
323098001907	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
323098001908	Sel1-like repeats; Region: SEL1; smart00671
323098001909	Sel1-like repeats; Region: SEL1; smart00671
323098001910	Sel1-like repeats; Region: SEL1; smart00671
323098001911	Sel1-like repeats; Region: SEL1; smart00671
323098001912	Sel1-like repeats; Region: SEL1; smart00671
323098001913	Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579
323098001914	putative ligand binding site [chemical binding]; other site
323098001915	putative catalytic site [active]
323098001916	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
323098001917	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
323098001918	active site
323098001919	Glycoside hydrolase families 71, 99, and related domains; Region: GH99_GH71_like; cl01529
323098001920	ligand binding site [chemical binding]; other site
323098001921	putative catalytic site [active]
323098001922	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
323098001923	TPR motif; other site
323098001924	Tetratricopeptide repeat; Region: TPR_16; pfam13432
323098001925	binding surface
323098001926	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
323098001927	active site
323098001928	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
323098001929	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
323098001930	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
323098001931	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
323098001932	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
323098001933	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
323098001934	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
323098001935	NAD binding site [chemical binding]; other site
323098001936	substrate binding site [chemical binding]; other site
323098001937	homodimer interface [polypeptide binding]; other site
323098001938	active site
323098001939	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
323098001940	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
323098001941	substrate binding site; other site
323098001942	tetramer interface; other site
323098001943	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
323098001944	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
323098001945	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
323098001946	NADP binding site [chemical binding]; other site
323098001947	active site
323098001948	putative substrate binding site [chemical binding]; other site
323098001949	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
323098001950	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
323098001951	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
323098001952	Probable Catalytic site; other site
323098001953	metal-binding site
323098001954	TPR repeat; Region: TPR_11; pfam13414
323098001955	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
323098001956	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
323098001957	Probable Catalytic site; other site
323098001958	metal-binding site
323098001959	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
323098001960	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
323098001961	putative ADP-binding pocket [chemical binding]; other site
323098001962	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
323098001963	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
323098001964	motif II; other site
323098001965	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
323098001966	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
323098001967	G1 box; other site
323098001968	putative GEF interaction site [polypeptide binding]; other site
323098001969	GTP/Mg2+ binding site [chemical binding]; other site
323098001970	Switch I region; other site
323098001971	G2 box; other site
323098001972	G3 box; other site
323098001973	Switch II region; other site
323098001974	G4 box; other site
323098001975	G5 box; other site
323098001976	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
323098001977	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
323098001978	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
323098001979	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
323098001980	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
323098001981	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323098001982	active site
323098001983	phosphorylation site [posttranslational modification]
323098001984	intermolecular recognition site; other site
323098001985	dimerization interface [polypeptide binding]; other site
323098001986	NnrS protein; Region: NnrS; pfam05940
323098001987	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
323098001988	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
323098001989	HWE histidine kinase; Region: HWE_HK; smart00911
323098001990	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
323098001991	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
323098001992	ligand binding site [chemical binding]; other site
323098001993	flexible hinge region; other site
323098001994	putative indolepyruvate oxidoreductase subunit B; Reviewed; Region: PRK08312
323098001995	MarR family; Region: MarR_2; pfam12802
323098001996	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
323098001997	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
323098001998	MOFRL family; Region: MOFRL; pfam05161
323098001999	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
323098002000	Peptidase family M23; Region: Peptidase_M23; pfam01551
323098002001	AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The...; Region: Rieske_AIFL_N; cd03478
323098002002	[2Fe-2S] cluster binding site [ion binding]; other site
323098002003	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
323098002004	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
323098002005	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
323098002006	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
323098002007	active site
323098002008	DNA binding site [nucleotide binding]
323098002009	Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
323098002010	Response regulator receiver domain; Region: Response_reg; pfam00072
323098002011	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323098002012	active site
323098002013	phosphorylation site [posttranslational modification]
323098002014	intermolecular recognition site; other site
323098002015	dimerization interface [polypeptide binding]; other site
323098002016	MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098
323098002017	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
323098002018	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
323098002019	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
323098002020	Walker A/P-loop; other site
323098002021	ATP binding site [chemical binding]; other site
323098002022	Q-loop/lid; other site
323098002023	ABC transporter signature motif; other site
323098002024	Walker B; other site
323098002025	D-loop; other site
323098002026	H-loop/switch region; other site
323098002027	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
323098002028	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
323098002029	Uncharacterized conserved protein [Function unknown]; Region: COG1434
323098002030	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
323098002031	putative active site [active]
323098002032	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
323098002033	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
323098002034	putative acyl-acceptor binding pocket; other site
323098002035	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
323098002036	putative active site pocket [active]
323098002037	dimerization interface [polypeptide binding]; other site
323098002038	putative catalytic residue [active]
323098002039	Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898
323098002040	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
323098002041	prephenate dehydrogenase; Validated; Region: PRK08507
323098002042	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
323098002043	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
323098002044	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323098002045	homodimer interface [polypeptide binding]; other site
323098002046	catalytic residue [active]
323098002047	hypothetical protein; Provisional; Region: PRK06034
323098002048	Chorismate mutase type II; Region: CM_2; pfam01817
323098002049	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
323098002050	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
323098002051	Methyltransferase domain; Region: Methyltransf_23; pfam13489
323098002052	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323098002053	S-adenosylmethionine binding site [chemical binding]; other site
323098002054	TIGR02594 family protein; Region: TIGR02594
323098002055	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
323098002056	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
323098002057	MOSC domain; Region: MOSC; pfam03473
323098002058	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
323098002059	Clp amino terminal domain; Region: Clp_N; pfam02861
323098002060	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323098002061	Walker A motif; other site
323098002062	ATP binding site [chemical binding]; other site
323098002063	Walker B motif; other site
323098002064	arginine finger; other site
323098002065	TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325
323098002066	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323098002067	Walker A motif; other site
323098002068	ATP binding site [chemical binding]; other site
323098002069	Walker B motif; other site
323098002070	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
323098002071	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
323098002072	Flavodoxin; Region: Flavodoxin_1; pfam00258
323098002073	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
323098002074	FAD binding pocket [chemical binding]; other site
323098002075	FAD binding motif [chemical binding]; other site
323098002076	catalytic residues [active]
323098002077	NAD binding pocket [chemical binding]; other site
323098002078	phosphate binding motif [ion binding]; other site
323098002079	beta-alpha-beta structure motif; other site
323098002080	sulfite reductase subunit beta; Provisional; Region: PRK13504
323098002081	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
323098002082	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
323098002083	O-succinylhomoserine (thiol)-lyase; Region: O_succ_thio_ly; TIGR02080
323098002084	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
323098002085	homodimer interface [polypeptide binding]; other site
323098002086	substrate-cofactor binding pocket; other site
323098002087	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323098002088	catalytic residue [active]
323098002089	BA14K-like protein; Region: BA14K; pfam07886
323098002090	ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507
323098002091	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323098002092	AAA domain; Region: AAA_30; pfam13604
323098002093	Walker A motif; other site
323098002094	ATP binding site [chemical binding]; other site
323098002095	Family description; Region: UvrD_C_2; pfam13538
323098002096	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
323098002097	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323098002098	Walker A motif; other site
323098002099	ATP binding site [chemical binding]; other site
323098002100	Walker B motif; other site
323098002101	arginine finger; other site
323098002102	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
323098002103	flagellar motor switch protein; Reviewed; Region: PRK08916
323098002104	flagellar assembly protein H; Validated; Region: fliH; PRK06032
323098002105	Flagellar assembly protein FliH; Region: FliH; pfam02108
323098002106	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
323098002107	MgtE intracellular N domain; Region: MgtE_N; cl15244
323098002108	FliG C-terminal domain; Region: FliG_C; pfam01706
323098002109	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
323098002110	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
323098002111	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
323098002112	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
323098002113	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
323098002114	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
323098002115	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
323098002116	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
323098002117	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
323098002118	Ligand Binding Site [chemical binding]; other site
323098002119	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323098002120	S-adenosylmethionine binding site [chemical binding]; other site
323098002121	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
323098002122	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
323098002123	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
323098002124	TrkA-N domain; Region: TrkA_N; pfam02254
323098002125	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
323098002126	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
323098002127	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
323098002128	dimerization interface [polypeptide binding]; other site
323098002129	active site
323098002130	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
323098002131	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
323098002132	FAD binding site [chemical binding]; other site
323098002133	substrate binding pocket [chemical binding]; other site
323098002134	catalytic base [active]
323098002135	ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187
323098002136	ATP-grasp domain; Region: ATP-grasp_4; cl17255
323098002137	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
323098002138	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
323098002139	Walker A/P-loop; other site
323098002140	ATP binding site [chemical binding]; other site
323098002141	Q-loop/lid; other site
323098002142	ABC transporter signature motif; other site
323098002143	Walker B; other site
323098002144	D-loop; other site
323098002145	H-loop/switch region; other site
323098002146	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
323098002147	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
323098002148	LysR family transcriptional regulator; Provisional; Region: PRK14997
323098002149	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
323098002150	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
323098002151	putative effector binding pocket; other site
323098002152	putative dimerization interface [polypeptide binding]; other site
323098002153	Pirin-related protein [General function prediction only]; Region: COG1741
323098002154	Pirin; Region: Pirin; pfam02678
323098002155	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
323098002156	putative acyl-CoA synthetase; Provisional; Region: PRK06018
323098002157	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
323098002158	dimer interface [polypeptide binding]; other site
323098002159	acyl-activating enzyme (AAE) consensus motif; other site
323098002160	putative active site [active]
323098002161	AMP binding site [chemical binding]; other site
323098002162	putative CoA binding site [chemical binding]; other site
323098002163	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
323098002164	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
323098002165	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
323098002166	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
323098002167	classical (c) SDRs; Region: SDR_c; cd05233
323098002168	NAD(P) binding site [chemical binding]; other site
323098002169	active site
323098002170	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
323098002171	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
323098002172	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
323098002173	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
323098002174	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
323098002175	HSP70 interaction site [polypeptide binding]; other site
323098002176	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
323098002177	substrate binding site [polypeptide binding]; other site
323098002178	dimer interface [polypeptide binding]; other site
323098002179	Autoinducer synthetase; Region: Autoind_synth; cl17404
323098002180	LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541
323098002181	Autoinducer binding domain; Region: Autoind_bind; pfam03472
323098002182	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
323098002183	DNA binding residues [nucleotide binding]
323098002184	dimerization interface [polypeptide binding]; other site
323098002185	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
323098002186	catalytic core [active]
323098002187	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
323098002188	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
323098002189	Tetramer interface [polypeptide binding]; other site
323098002190	active site
323098002191	FMN-binding site [chemical binding]; other site
323098002192	ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019
323098002193	TRAM domain; Region: TRAM; cl01282
323098002194	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
323098002195	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
323098002196	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
323098002197	RNA binding surface [nucleotide binding]; other site
323098002198	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
323098002199	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
323098002200	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
323098002201	TPP-binding site; other site
323098002202	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
323098002203	PYR/PP interface [polypeptide binding]; other site
323098002204	dimer interface [polypeptide binding]; other site
323098002205	TPP binding site [chemical binding]; other site
323098002206	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
323098002207	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
323098002208	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
323098002209	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
323098002210	putative active site [active]
323098002211	Zn binding site [ion binding]; other site
323098002212	enoyl-CoA hydratase; Provisional; Region: PRK06688
323098002213	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
323098002214	substrate binding site [chemical binding]; other site
323098002215	oxyanion hole (OAH) forming residues; other site
323098002216	trimer interface [polypeptide binding]; other site
323098002217	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
323098002218	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
323098002219	active site
323098002220	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
323098002221	Transposase; Region: HTH_Tnp_1; pfam01527
323098002222	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323098002223	Helix-turn-helix domain; Region: HTH_28; pfam13518
323098002224	Winged helix-turn helix; Region: HTH_29; pfam13551
323098002225	Homeodomain-like domain; Region: HTH_32; pfam13565
323098002226	Integrase core domain; Region: rve; pfam00665
323098002227	Integrase core domain; Region: rve_3; pfam13683
323098002228	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
323098002229	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
323098002230	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
323098002231	inhibitor-cofactor binding pocket; inhibition site
323098002232	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323098002233	catalytic residue [active]
323098002234	UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589
323098002235	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
323098002236	NAD(P) binding site [chemical binding]; other site
323098002237	homodimer interface [polypeptide binding]; other site
323098002238	substrate binding site [chemical binding]; other site
323098002239	active site
323098002240	SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518
323098002241	ligand binding site; other site
323098002242	pseudaminic acid biosynthesis-associated methylase; Region: Pse_Me-ase; TIGR03587
323098002243	pseudaminic acid synthase; Region: PseI; TIGR03586
323098002244	NeuB family; Region: NeuB; pfam03102
323098002245	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
323098002246	NeuB binding interface [polypeptide binding]; other site
323098002247	putative substrate binding site [chemical binding]; other site
323098002248	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
323098002249	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
323098002250	motif II; other site
323098002251	Methyltransferase domain; Region: Methyltransf_31; pfam13847
323098002252	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323098002253	S-adenosylmethionine binding site [chemical binding]; other site
323098002254	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
323098002255	MOSC domain; Region: MOSC; pfam03473
323098002256	3-alpha domain; Region: 3-alpha; pfam03475
323098002257	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
323098002258	Beta-lactamase; Region: Beta-lactamase; pfam00144
323098002259	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
323098002260	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323098002261	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323098002262	Winged helix-turn helix; Region: HTH_29; pfam13551
323098002263	Homeodomain-like domain; Region: HTH_23; cl17451
323098002264	Homeodomain-like domain; Region: HTH_32; pfam13565
323098002265	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
323098002266	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
323098002267	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
323098002268	DNA binding residues [nucleotide binding]
323098002269	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
323098002270	FecR protein; Region: FecR; pfam04773
323098002271	Secretin and TonB N terminus short domain; Region: STN; smart00965
323098002272	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
323098002273	N-terminal plug; other site
323098002274	ligand-binding site [chemical binding]; other site
323098002275	Transposase; Region: HTH_Tnp_1; pfam01527
323098002276	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323098002277	Helix-turn-helix domain; Region: HTH_28; pfam13518
323098002278	Winged helix-turn helix; Region: HTH_29; pfam13551
323098002279	Homeodomain-like domain; Region: HTH_32; pfam13565
323098002280	Integrase core domain; Region: rve; pfam00665
323098002281	Integrase core domain; Region: rve_3; pfam13683
323098002282	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
323098002283	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
323098002284	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
323098002285	non-specific DNA binding site [nucleotide binding]; other site
323098002286	salt bridge; other site
323098002287	sequence-specific DNA binding site [nucleotide binding]; other site
323098002288	Cupin domain; Region: Cupin_2; pfam07883
323098002289	Porin subfamily; Region: Porin_2; pfam02530
323098002290	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
323098002291	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
323098002292	TM-ABC transporter signature motif; other site
323098002293	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
323098002294	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
323098002295	TM-ABC transporter signature motif; other site
323098002296	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
323098002297	Type I periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; Region: PBP1_alkylbenzenes_like; cd06360
323098002298	putative ligand binding site [chemical binding]; other site
323098002299	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
323098002300	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
323098002301	Walker A/P-loop; other site
323098002302	ATP binding site [chemical binding]; other site
323098002303	Q-loop/lid; other site
323098002304	ABC transporter signature motif; other site
323098002305	Walker B; other site
323098002306	D-loop; other site
323098002307	H-loop/switch region; other site
323098002308	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
323098002309	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
323098002310	Walker A/P-loop; other site
323098002311	ATP binding site [chemical binding]; other site
323098002312	Q-loop/lid; other site
323098002313	ABC transporter signature motif; other site
323098002314	Walker B; other site
323098002315	D-loop; other site
323098002316	H-loop/switch region; other site
323098002317	Cytochrome c; Region: Cytochrom_C; cl11414
323098002318	Cytochrome c; Region: Cytochrom_C; cl11414
323098002319	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
323098002320	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
323098002321	Walker A/P-loop; other site
323098002322	ATP binding site [chemical binding]; other site
323098002323	Q-loop/lid; other site
323098002324	ABC transporter signature motif; other site
323098002325	Walker B; other site
323098002326	D-loop; other site
323098002327	H-loop/switch region; other site
323098002328	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
323098002329	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
323098002330	dimer interface [polypeptide binding]; other site
323098002331	conserved gate region; other site
323098002332	putative PBP binding loops; other site
323098002333	ABC-ATPase subunit interface; other site
323098002334	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
323098002335	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
323098002336	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
323098002337	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
323098002338	ligand binding site [chemical binding]; other site
323098002339	flexible hinge region; other site
323098002340	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
323098002341	putative switch regulator; other site
323098002342	non-specific DNA interactions [nucleotide binding]; other site
323098002343	DNA binding site [nucleotide binding]
323098002344	sequence specific DNA binding site [nucleotide binding]; other site
323098002345	putative cAMP binding site [chemical binding]; other site
323098002346	HEAT repeats; Region: HEAT_2; pfam13646
323098002347	HEAT repeats; Region: HEAT_2; pfam13646
323098002348	HEAT-like repeat; Region: HEAT_EZ; pfam13513
323098002349	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
323098002350	HEAT-like repeat; Region: HEAT_EZ; pfam13513
323098002351	protein binding surface [polypeptide binding]; other site
323098002352	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
323098002353	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
323098002354	putative oxidoreductase; Provisional; Region: PRK08275
323098002355	L-aspartate oxidase; Provisional; Region: PRK06175
323098002356	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
323098002357	Protein of unknown function (DUF971); Region: DUF971; pfam06155
323098002358	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
323098002359	substrate binding pocket [chemical binding]; other site
323098002360	membrane-bound complex binding site; other site
323098002361	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
323098002362	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
323098002363	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
323098002364	active site
323098002365	dimer interface [polypeptide binding]; other site
323098002366	non-prolyl cis peptide bond; other site
323098002367	insertion regions; other site
323098002368	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
323098002369	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
323098002370	dimer interface [polypeptide binding]; other site
323098002371	conserved gate region; other site
323098002372	putative PBP binding loops; other site
323098002373	ABC-ATPase subunit interface; other site
323098002374	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
323098002375	Walker A/P-loop; other site
323098002376	ATP binding site [chemical binding]; other site
323098002377	ABC transporter; Region: ABC_tran; pfam00005
323098002378	Q-loop/lid; other site
323098002379	ABC transporter signature motif; other site
323098002380	Walker B; other site
323098002381	D-loop; other site
323098002382	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
323098002383	H-loop/switch region; other site
323098002384	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
323098002385	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
323098002386	dimer interface [polypeptide binding]; other site
323098002387	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
323098002388	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
323098002389	FeS/SAM binding site; other site
323098002390	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
323098002391	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402
323098002392	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
323098002393	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
323098002394	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
323098002395	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
323098002396	Cytochrome c; Region: Cytochrom_C; pfam00034
323098002397	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
323098002398	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
323098002399	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323098002400	Protein of unknown function (DUF962); Region: DUF962; cl01879
323098002401	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
323098002402	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
323098002403	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
323098002404	catalytic residue [active]
323098002405	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666
323098002406	catecholate siderophore receptor Fiu; Provisional; Region: PRK09840
323098002407	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
323098002408	N-terminal plug; other site
323098002409	ligand-binding site [chemical binding]; other site
323098002410	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
323098002411	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
323098002412	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
323098002413	active site
323098002414	substrate binding site [chemical binding]; other site
323098002415	FMN binding site [chemical binding]; other site
323098002416	putative catalytic residues [active]
323098002417	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
323098002418	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
323098002419	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
323098002420	TonB C terminal; Region: TonB_2; pfam13103
323098002421	Invasion associated locus B (IalB) protein; Region: IalB; pfam06776
323098002422	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323098002423	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323098002424	Winged helix-turn helix; Region: HTH_29; pfam13551
323098002425	Homeodomain-like domain; Region: HTH_23; cl17451
323098002426	Homeodomain-like domain; Region: HTH_32; pfam13565
323098002427	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
323098002428	Cytochrome c2 [Energy production and conversion]; Region: COG3474
323098002429	diaminopimelate decarboxylase; Region: lysA; TIGR01048
323098002430	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
323098002431	active site
323098002432	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
323098002433	substrate binding site [chemical binding]; other site
323098002434	catalytic residues [active]
323098002435	dimer interface [polypeptide binding]; other site
323098002436	argininosuccinate lyase; Provisional; Region: PRK00855
323098002437	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
323098002438	active sites [active]
323098002439	tetramer interface [polypeptide binding]; other site
323098002440	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
323098002441	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
323098002442	catalytic residues [active]
323098002443	G8 domain; Region: G8; pfam10162
323098002444	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
323098002445	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
323098002446	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
323098002447	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
323098002448	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
323098002449	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
323098002450	[2Fe-2S] cluster binding site [ion binding]; other site
323098002451	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
323098002452	glutathionine S-transferase; Provisional; Region: PRK10542
323098002453	C-terminal domain interface [polypeptide binding]; other site
323098002454	GSH binding site (G-site) [chemical binding]; other site
323098002455	dimer interface [polypeptide binding]; other site
323098002456	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
323098002457	dimer interface [polypeptide binding]; other site
323098002458	substrate binding pocket (H-site) [chemical binding]; other site
323098002459	N-terminal domain interface [polypeptide binding]; other site
323098002460	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
323098002461	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
323098002462	FecR protein; Region: FecR; pfam04773
323098002463	Secretin and TonB N terminus short domain; Region: STN; smart00965
323098002464	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
323098002465	N-terminal plug; other site
323098002466	ligand-binding site [chemical binding]; other site
323098002467	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
323098002468	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
323098002469	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
323098002470	Helix-turn-helix domain; Region: HTH_37; pfam13744
323098002471	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
323098002472	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
323098002473	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
323098002474	Integrase core domain; Region: rve_3; pfam13683
323098002475	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
323098002476	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
323098002477	catalytic residues [active]
323098002478	catalytic nucleophile [active]
323098002479	Recombinase; Region: Recombinase; pfam07508
323098002480	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
323098002481	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
323098002482	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
323098002483	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
323098002484	catalytic residues [active]
323098002485	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
323098002486	apolar tunnel; other site
323098002487	heme binding site [chemical binding]; other site
323098002488	dimerization interface [polypeptide binding]; other site
323098002489	Transcriptional regulator; Region: Rrf2; cl17282
323098002490	Predicted transcriptional regulator [Transcription]; Region: COG1959
323098002491	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
323098002492	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
323098002493	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
323098002494	protein binding site [polypeptide binding]; other site
323098002495	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
323098002496	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
323098002497	active site
323098002498	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
323098002499	endonuclease III; Region: ENDO3c; smart00478
323098002500	minor groove reading motif; other site
323098002501	helix-hairpin-helix signature motif; other site
323098002502	substrate binding pocket [chemical binding]; other site
323098002503	active site
323098002504	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
323098002505	active site
323098002506	HIGH motif; other site
323098002507	nucleotide binding site [chemical binding]; other site
323098002508	active site
323098002509	KMSKS motif; other site
323098002510	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
323098002511	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323098002512	dimer interface [polypeptide binding]; other site
323098002513	phosphorylation site [posttranslational modification]
323098002514	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323098002515	ATP binding site [chemical binding]; other site
323098002516	Mg2+ binding site [ion binding]; other site
323098002517	G-X-G motif; other site
323098002518	Response regulator receiver domain; Region: Response_reg; pfam00072
323098002519	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323098002520	active site
323098002521	phosphorylation site [posttranslational modification]
323098002522	intermolecular recognition site; other site
323098002523	dimerization interface [polypeptide binding]; other site
323098002524	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
323098002525	Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588
323098002526	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
323098002527	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
323098002528	Ligand binding site [chemical binding]; other site
323098002529	Electron transfer flavoprotein domain; Region: ETF; pfam01012
323098002530	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
323098002531	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
323098002532	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
323098002533	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530
323098002534	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
323098002535	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
323098002536	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
323098002537	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
323098002538	P-loop, Walker A motif; other site
323098002539	Base recognition motif; other site
323098002540	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
323098002541	AAA domain; Region: AAA_17; pfam13207
323098002542	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
323098002543	homodimer interaction site [polypeptide binding]; other site
323098002544	cofactor binding site; other site
323098002545	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00051
323098002546	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
323098002547	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
323098002548	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
323098002549	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
323098002550	Subunit I/III interface [polypeptide binding]; other site
323098002551	D-pathway; other site
323098002552	Subunit I/VIIc interface [polypeptide binding]; other site
323098002553	Subunit I/IV interface [polypeptide binding]; other site
323098002554	Subunit I/II interface [polypeptide binding]; other site
323098002555	Low-spin heme (heme a) binding site [chemical binding]; other site
323098002556	Subunit I/VIIa interface [polypeptide binding]; other site
323098002557	Subunit I/VIa interface [polypeptide binding]; other site
323098002558	Dimer interface; other site
323098002559	Putative water exit pathway; other site
323098002560	Binuclear center (heme a3/CuB) [ion binding]; other site
323098002561	K-pathway; other site
323098002562	Subunit I/Vb interface [polypeptide binding]; other site
323098002563	Putative proton exit pathway; other site
323098002564	Subunit I/VIb interface; other site
323098002565	Subunit I/VIc interface [polypeptide binding]; other site
323098002566	Electron transfer pathway; other site
323098002567	Subunit I/VIIIb interface [polypeptide binding]; other site
323098002568	Subunit I/VIIb interface [polypeptide binding]; other site
323098002569	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
323098002570	UbiA prenyltransferase family; Region: UbiA; pfam01040
323098002571	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
323098002572	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
323098002573	Subunit III/VIIa interface [polypeptide binding]; other site
323098002574	Phospholipid binding site [chemical binding]; other site
323098002575	Subunit I/III interface [polypeptide binding]; other site
323098002576	Subunit III/VIb interface [polypeptide binding]; other site
323098002577	Subunit III/VIa interface; other site
323098002578	Subunit III/Vb interface [polypeptide binding]; other site
323098002579	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349
323098002580	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
323098002581	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
323098002582	Subunit I/III interface [polypeptide binding]; other site
323098002583	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
323098002584	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
323098002585	D-pathway; other site
323098002586	Putative ubiquinol binding site [chemical binding]; other site
323098002587	Low-spin heme (heme b) binding site [chemical binding]; other site
323098002588	Putative water exit pathway; other site
323098002589	Binuclear center (heme o3/CuB) [ion binding]; other site
323098002590	K-pathway; other site
323098002591	Putative proton exit pathway; other site
323098002592	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
323098002593	Cytochrome c; Region: Cytochrom_C; pfam00034
323098002594	Cytochrome c; Region: Cytochrom_C; pfam00034
323098002595	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
323098002596	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
323098002597	[4Fe-4S] binding site [ion binding]; other site
323098002598	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
323098002599	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
323098002600	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
323098002601	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
323098002602	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
323098002603	molybdopterin cofactor binding site; other site
323098002604	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
323098002605	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
323098002606	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
323098002607	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323098002608	putative substrate translocation pore; other site
323098002609	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
323098002610	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319
323098002611	gating phenylalanine in ion channel; other site
323098002612	Integrase core domain; Region: rve; pfam00665
323098002613	Integrase core domain; Region: rve_3; pfam13683
323098002614	Transposase; Region: HTH_Tnp_1; pfam01527
323098002615	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323098002616	TIGR02594 family protein; Region: TIGR02594
323098002617	Protein of unknown function (DUF2793); Region: DUF2793; pfam10983
323098002618	GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547
323098002619	Putative phage tail protein; Region: Phage-tail_3; pfam13550
323098002620	NlpC/P60 family; Region: NLPC_P60; cl17555
323098002621	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
323098002622	Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931
323098002623	phage conserved hypothetical protein BR0599; Region: phg_TIGR02218
323098002624	Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356
323098002625	Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343
323098002626	Phage-related minor tail protein [Function unknown]; Region: COG5281
323098002627	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
323098002628	Uncharacterized conserved protein (DUF2190); Region: DUF2190; pfam09956
323098002629	Caudovirus prohead protease; Region: Peptidase_U35; cl01521
323098002630	Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136
323098002631	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
323098002632	Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876
323098002633	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
323098002634	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323098002635	S-adenosylmethionine binding site [chemical binding]; other site
323098002636	ParB-like nuclease domain; Region: ParBc; pfam02195
323098002637	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
323098002638	AAA domain; Region: AAA_25; pfam13481
323098002639	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
323098002640	Walker A motif; other site
323098002641	ATP binding site [chemical binding]; other site
323098002642	Walker B motif; other site
323098002643	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
323098002644	Helix-turn-helix domain; Region: HTH_17; pfam12728
323098002645	Domain of unknown function (DUF955); Region: DUF955; cl01076
323098002646	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
323098002647	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
323098002648	non-specific DNA binding site [nucleotide binding]; other site
323098002649	salt bridge; other site
323098002650	sequence-specific DNA binding site [nucleotide binding]; other site
323098002651	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
323098002652	DNA protecting protein DprA; Region: dprA; TIGR00732
323098002653	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
323098002654	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
323098002655	non-specific DNA binding site [nucleotide binding]; other site
323098002656	salt bridge; other site
323098002657	sequence-specific DNA binding site [nucleotide binding]; other site
323098002658	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
323098002659	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
323098002660	active site
323098002661	Int/Topo IB signature motif; other site
323098002662	DNA binding site [nucleotide binding]
323098002663	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
323098002664	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
323098002665	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
323098002666	Magnesium ion binding site [ion binding]; other site
323098002667	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
323098002668	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
323098002669	catalytic residues [active]
323098002670	Recombinase; Region: Recombinase; pfam07508
323098002671	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
323098002672	Coenzyme A binding pocket [chemical binding]; other site
323098002673	Protein of unknown function (DUF1778); Region: DUF1778; pfam08681
323098002674	Integrase core domain; Region: rve; pfam00665
323098002675	Integrase core domain; Region: rve_3; pfam13683
323098002676	Protein of unknown function (DUF736); Region: DUF736; pfam05284
323098002677	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323098002678	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
323098002679	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
323098002680	non-specific DNA binding site [nucleotide binding]; other site
323098002681	salt bridge; other site
323098002682	sequence-specific DNA binding site [nucleotide binding]; other site
323098002683	Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246
323098002684	Helix-turn-helix domain; Region: HTH_17; pfam12728
323098002685	Replication initiator protein A; Region: RPA; pfam10134
323098002686	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
323098002687	DNA methylase; Region: N6_N4_Mtase; pfam01555
323098002688	Protein of unknown function (DUF2840); Region: DUF2840; pfam11000
323098002689	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
323098002690	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
323098002691	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
323098002692	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
323098002693	N-acetyl-D-glucosamine binding site [chemical binding]; other site
323098002694	catalytic residue [active]
323098002695	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323098002696	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323098002697	Winged helix-turn helix; Region: HTH_29; pfam13551
323098002698	Homeodomain-like domain; Region: HTH_23; cl17451
323098002699	Homeodomain-like domain; Region: HTH_32; pfam13565
323098002700	Transposase; Region: DEDD_Tnp_IS110; pfam01548
323098002701	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
323098002702	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
323098002703	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
323098002704	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
323098002705	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
323098002706	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
323098002707	oligomeric interface; other site
323098002708	putative active site [active]
323098002709	homodimer interface [polypeptide binding]; other site
323098002710	Putative transcription activator [Transcription]; Region: TenA; COG0819
323098002711	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
323098002712	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
323098002713	Protein of unknown function (DUF2274); Region: DUF2274; pfam10038
323098002714	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
323098002715	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
323098002716	AAA domain; Region: AAA_23; pfam13476
323098002717	Walker A/P-loop; other site
323098002718	ATP binding site [chemical binding]; other site
323098002719	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
323098002720	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
323098002721	Helix-turn-helix domain; Region: HTH_28; pfam13518
323098002722	Winged helix-turn helix; Region: HTH_29; pfam13551
323098002723	Homeodomain-like domain; Region: HTH_32; pfam13565
323098002724	Integrase core domain; Region: rve; pfam00665
323098002725	Integrase core domain; Region: rve_3; pfam13683
323098002726	Transposase; Region: HTH_Tnp_1; pfam01527
323098002727	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323098002728	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
323098002729	Transposase; Region: HTH_Tnp_1; pfam01527
323098002730	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323098002731	Helix-turn-helix domain; Region: HTH_28; pfam13518
323098002732	putative transposase OrfB; Reviewed; Region: PHA02517
323098002733	Homeodomain-like domain; Region: HTH_32; pfam13565
323098002734	Integrase core domain; Region: rve; pfam00665
323098002735	Integrase core domain; Region: rve_3; pfam13683
323098002736	Transposase; Region: HTH_Tnp_1; pfam01527
323098002737	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323098002738	Helix-turn-helix domain; Region: HTH_28; pfam13518
323098002739	Winged helix-turn helix; Region: HTH_29; pfam13551
323098002740	Homeodomain-like domain; Region: HTH_32; pfam13565
323098002741	Integrase core domain; Region: rve; pfam00665
323098002742	Integrase core domain; Region: rve_3; pfam13683
323098002743	Family of unknown function (DUF490); Region: DUF490; pfam04357
323098002744	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
323098002745	Surface antigen; Region: Bac_surface_Ag; pfam01103
323098002746	Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile.  CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902
323098002747	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
323098002748	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
323098002749	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
323098002750	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
323098002751	putative catalytic residue [active]
323098002752	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
323098002753	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
323098002754	molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537
323098002755	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
323098002756	DNA-binding site [nucleotide binding]; DNA binding site
323098002757	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
323098002758	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
323098002759	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323098002760	homodimer interface [polypeptide binding]; other site
323098002761	catalytic residue [active]
323098002762	class II aldolase/adducin domain protein; Provisional; Region: PRK07090
323098002763	intersubunit interface [polypeptide binding]; other site
323098002764	active site
323098002765	Zn2+ binding site [ion binding]; other site
323098002766	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
323098002767	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
323098002768	inhibitor site; inhibition site
323098002769	active site
323098002770	dimer interface [polypeptide binding]; other site
323098002771	catalytic residue [active]
323098002772	Clostridium P-47 protein; Region: Clostridium_P47; pfam06597
323098002773	Clostridium P-47 protein; Region: Clostridium_P47; pfam06597
323098002774	Clostridium P-47 protein; Region: Clostridium_P47; pfam06597
323098002775	Clostridium P-47 protein; Region: Clostridium_P47; pfam06597
323098002776	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
323098002777	Putative phosphatase (DUF442); Region: DUF442; cl17385
323098002778	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
323098002779	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
323098002780	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
323098002781	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
323098002782	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
323098002783	dimerization interface [polypeptide binding]; other site
323098002784	putative DNA binding site [nucleotide binding]; other site
323098002785	putative Zn2+ binding site [ion binding]; other site
323098002786	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895
323098002787	putative hydrophobic ligand binding site [chemical binding]; other site
323098002788	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
323098002789	extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037
323098002790	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
323098002791	DNA binding residues [nucleotide binding]
323098002792	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
323098002793	FecR protein; Region: FecR; pfam04773
323098002794	Secretin and TonB N terminus short domain; Region: STN; smart00965
323098002795	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
323098002796	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
323098002797	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
323098002798	putative NADP binding site [chemical binding]; other site
323098002799	putative substrate binding site [chemical binding]; other site
323098002800	active site
323098002801	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
323098002802	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
323098002803	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
323098002804	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
323098002805	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
323098002806	Cupin domain; Region: Cupin_2; cl17218
323098002807	AAA domain; Region: AAA_27; pfam13514
323098002808	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
323098002809	active site
323098002810	metal binding site [ion binding]; metal-binding site
323098002811	DNA binding site [nucleotide binding]
323098002812	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
323098002813	Part of AAA domain; Region: AAA_19; pfam13245
323098002814	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
323098002815	AAA domain; Region: AAA_30; pfam13604
323098002816	AAA domain; Region: AAA_12; pfam13087
323098002817	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
323098002818	putative active site [active]
323098002819	Protein of unknown function (DUF3320); Region: DUF3320; pfam11784
323098002820	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
323098002821	putative homodimer interface [polypeptide binding]; other site
323098002822	putative homotetramer interface [polypeptide binding]; other site
323098002823	putative allosteric switch controlling residues; other site
323098002824	putative metal binding site [ion binding]; other site
323098002825	putative homodimer-homodimer interface [polypeptide binding]; other site
323098002826	YHS domain; Region: YHS; pfam04945
323098002827	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
323098002828	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
323098002829	Soluble P-type ATPase [General function prediction only]; Region: COG4087
323098002830	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
323098002831	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
323098002832	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
323098002833	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
323098002834	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
323098002835	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
323098002836	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
323098002837	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
323098002838	ABC-ATPase subunit  interface; other site
323098002839	dimer interface [polypeptide binding]; other site
323098002840	putative PBP binding regions; other site
323098002841	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
323098002842	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
323098002843	intersubunit interface [polypeptide binding]; other site
323098002844	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
323098002845	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
323098002846	P-loop, Walker A motif; other site
323098002847	Base recognition motif; other site
323098002848	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
323098002849	FOG: WD40 repeat [General function prediction only]; Region: COG2319
323098002850	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
323098002851	structural tetrad; other site
323098002852	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
323098002853	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
323098002854	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
323098002855	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
323098002856	Predicted acetyltransferase [General function prediction only]; Region: COG3153
323098002857	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
323098002858	dimer interface [polypeptide binding]; other site
323098002859	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
323098002860	active site
323098002861	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
323098002862	catalytic residues [active]
323098002863	substrate binding site [chemical binding]; other site
323098002864	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
323098002865	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
323098002866	active site
323098002867	Zn binding site [ion binding]; other site
323098002868	MAPEG family; Region: MAPEG; cl09190
323098002869	ferrochelatase; Reviewed; Region: hemH; PRK00035
323098002870	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
323098002871	C-terminal domain interface [polypeptide binding]; other site
323098002872	active site
323098002873	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
323098002874	active site
323098002875	N-terminal domain interface [polypeptide binding]; other site
323098002876	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
323098002877	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
323098002878	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
323098002879	KpsF/GutQ family protein; Region: kpsF; TIGR00393
323098002880	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
323098002881	putative active site [active]
323098002882	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
323098002883	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
323098002884	Protein of unknown function (DUF2478); Region: DUF2478; pfam10649
323098002885	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
323098002886	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
323098002887	Protein of unknown function (DUF3772); Region: DUF3772; pfam12607
323098002888	Mechanosensitive ion channel; Region: MS_channel; pfam00924
323098002889	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
323098002890	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
323098002891	active site
323098002892	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
323098002893	NHAD transporter family protein; Provisional; Region: PLN00137; cl17324
323098002894	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
323098002895	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
323098002896	N-terminal plug; other site
323098002897	ligand-binding site [chemical binding]; other site
323098002898	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
323098002899	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
323098002900	hypothetical protein; Validated; Region: PRK00029
323098002901	Uncharacterized conserved protein [Function unknown]; Region: COG0397
323098002902	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
323098002903	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
323098002904	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
323098002905	active site
323098002906	catalytic site [active]
323098002907	AAK_UMPK-MosAB: This CD includes the alpha and beta subunits of the Mo storage protein (MosA and MosB) which are related to uridine monophosphate kinase (UMPK) enzymes that catalyze the phosphorylation of UMP by ATP, yielding UDP, and playing a key role...; Region: AAK_UMPK-MosAB; cd04255
323098002908	putative nucleotide binding site [chemical binding]; other site
323098002909	putative substrate binding site [chemical binding]; other site
323098002910	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
323098002911	nucleotide binding site [chemical binding]; other site
323098002912	substrate binding site [chemical binding]; other site
323098002913	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
323098002914	Glutamine amidotransferase class-I; Region: GATase; pfam00117
323098002915	glutamine binding [chemical binding]; other site
323098002916	catalytic triad [active]
323098002917	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
323098002918	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
323098002919	chorismate binding enzyme; Region: Chorismate_bind; cl10555
323098002920	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
323098002921	Ligand Binding Site [chemical binding]; other site
323098002922	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442
323098002923	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323098002924	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323098002925	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
323098002926	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
323098002927	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
323098002928	DNA binding residues [nucleotide binding]
323098002929	dimerization interface [polypeptide binding]; other site
323098002930	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
323098002931	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
323098002932	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
323098002933	Walker A/P-loop; other site
323098002934	ATP binding site [chemical binding]; other site
323098002935	Q-loop/lid; other site
323098002936	ABC transporter signature motif; other site
323098002937	Walker B; other site
323098002938	D-loop; other site
323098002939	H-loop/switch region; other site
323098002940	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
323098002941	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
323098002942	HlyD family secretion protein; Region: HlyD_3; pfam13437
323098002943	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
323098002944	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
323098002945	binding surface
323098002946	TPR motif; other site
323098002947	TPR repeat; Region: TPR_11; pfam13414
323098002948	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
323098002949	Common central domain of tyrosinase; Region: Tyrosinase; pfam00264
323098002950	Polyphenol oxidase middle domain; Region: PPO1_DWL; pfam12142
323098002951	methionine sulfoxide reductase A; Provisional; Region: PRK14054
323098002952	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323098002953	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323098002954	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
323098002955	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
323098002956	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
323098002957	GTP binding site; other site
323098002958	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
323098002959	CPxP  motif; other site
323098002960	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323098002961	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323098002962	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
323098002963	substrate binding site [chemical binding]; other site
323098002964	active site
323098002965	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
323098002966	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
323098002967	Pirin-related protein [General function prediction only]; Region: COG1741
323098002968	Pirin; Region: Pirin; pfam02678
323098002969	Transcriptional regulator [Transcription]; Region: LysR; COG0583
323098002970	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
323098002971	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
323098002972	putative effector binding pocket; other site
323098002973	dimerization interface [polypeptide binding]; other site
323098002974	Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839
323098002975	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
323098002976	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323098002977	active site
323098002978	phosphorylation site [posttranslational modification]
323098002979	intermolecular recognition site; other site
323098002980	dimerization interface [polypeptide binding]; other site
323098002981	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
323098002982	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
323098002983	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
323098002984	binding surface
323098002985	Tetratricopeptide repeat; Region: TPR_16; pfam13432
323098002986	TPR motif; other site
323098002987	pyruvate kinase; Provisional; Region: PRK06247
323098002988	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
323098002989	domain interfaces; other site
323098002990	active site
323098002991	Protein of unknown function (DUF1036); Region: DUF1036; pfam06282
323098002992	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492
323098002993	hypothetical protein; Provisional; Region: PRK13694
323098002994	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
323098002995	Peptidase M15; Region: Peptidase_M15_3; cl01194
323098002996	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
323098002997	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
323098002998	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
323098002999	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
323098003000	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323098003001	active site
323098003002	phosphorylation site [posttranslational modification]
323098003003	intermolecular recognition site; other site
323098003004	dimerization interface [polypeptide binding]; other site
323098003005	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323098003006	Walker A motif; other site
323098003007	ATP binding site [chemical binding]; other site
323098003008	Walker B motif; other site
323098003009	arginine finger; other site
323098003010	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
323098003011	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
323098003012	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
323098003013	active site
323098003014	Zn binding site [ion binding]; other site
323098003015	Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835
323098003016	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
323098003017	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
323098003018	ligand binding site [chemical binding]; other site
323098003019	homodimer interface [polypeptide binding]; other site
323098003020	NAD(P) binding site [chemical binding]; other site
323098003021	trimer interface B [polypeptide binding]; other site
323098003022	trimer interface A [polypeptide binding]; other site
323098003023	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
323098003024	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
323098003025	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
323098003026	Protein of unknown function (DUF3606); Region: DUF3606; pfam12244
323098003027	Protein of unknown function (DUF3606); Region: DUF3606; pfam12244
323098003028	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
323098003029	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
323098003030	amphipathic channel; other site
323098003031	Asn-Pro-Ala signature motifs; other site
323098003032	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
323098003033	ATP-grasp domain; Region: ATP-grasp; pfam02222
323098003034	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
323098003035	Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481
323098003036	Uncharacterized small protein [Function unknown]; Region: COG5570
323098003037	Predicted dehydrogenase [General function prediction only]; Region: COG0579
323098003038	hydroxyglutarate oxidase; Provisional; Region: PRK11728
323098003039	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
323098003040	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
323098003041	Walker A/P-loop; other site
323098003042	ATP binding site [chemical binding]; other site
323098003043	Q-loop/lid; other site
323098003044	ABC transporter signature motif; other site
323098003045	Walker B; other site
323098003046	D-loop; other site
323098003047	H-loop/switch region; other site
323098003048	TOBE domain; Region: TOBE_2; pfam08402
323098003049	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
323098003050	dimer interface [polypeptide binding]; other site
323098003051	conserved gate region; other site
323098003052	putative PBP binding loops; other site
323098003053	ABC-ATPase subunit interface; other site
323098003054	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
323098003055	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
323098003056	dimer interface [polypeptide binding]; other site
323098003057	conserved gate region; other site
323098003058	putative PBP binding loops; other site
323098003059	ABC-ATPase subunit interface; other site
323098003060	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
323098003061	Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203
323098003062	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
323098003063	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
323098003064	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
323098003065	PAS domain; Region: PAS_9; pfam13426
323098003066	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
323098003067	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323098003068	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
323098003069	putative active site [active]
323098003070	heme pocket [chemical binding]; other site
323098003071	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323098003072	dimer interface [polypeptide binding]; other site
323098003073	phosphorylation site [posttranslational modification]
323098003074	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323098003075	ATP binding site [chemical binding]; other site
323098003076	Mg2+ binding site [ion binding]; other site
323098003077	G-X-G motif; other site
323098003078	Phasin protein; Region: Phasin_2; cl11491
323098003079	phasin; Region: phasin_2; TIGR01985
323098003080	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323098003081	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
323098003082	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323098003083	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323098003084	Transposase; Region: HTH_Tnp_1; pfam01527
323098003085	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323098003086	Helix-turn-helix domain; Region: HTH_28; pfam13518
323098003087	Winged helix-turn helix; Region: HTH_29; pfam13551
323098003088	Homeodomain-like domain; Region: HTH_32; pfam13565
323098003089	Integrase core domain; Region: rve; pfam00665
323098003090	Integrase core domain; Region: rve_3; pfam13683
323098003091	FOG: CBS domain [General function prediction only]; Region: COG0517
323098003092	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
323098003093	FOG: CBS domain [General function prediction only]; Region: COG0517
323098003094	BON domain; Region: BON; pfam04972
323098003095	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
323098003096	Ligand Binding Site [chemical binding]; other site
323098003097	Glucokinase; Region: Glucokinase; pfam02685
323098003098	glucokinase, proteobacterial type; Region: glk; TIGR00749
323098003099	XFP N-terminal domain; Region: XFP_N; pfam09364
323098003100	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323098003101	Response regulator receiver domain; Region: Response_reg; pfam00072
323098003102	active site
323098003103	phosphorylation site [posttranslational modification]
323098003104	intermolecular recognition site; other site
323098003105	dimerization interface [polypeptide binding]; other site
323098003106	response regulator FixJ; Provisional; Region: fixJ; PRK09390
323098003107	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323098003108	active site
323098003109	phosphorylation site [posttranslational modification]
323098003110	intermolecular recognition site; other site
323098003111	dimerization interface [polypeptide binding]; other site
323098003112	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
323098003113	DNA binding residues [nucleotide binding]
323098003114	dimerization interface [polypeptide binding]; other site
323098003115	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
323098003116	PAS fold; Region: PAS_3; pfam08447
323098003117	putative active site [active]
323098003118	heme pocket [chemical binding]; other site
323098003119	PAS domain S-box; Region: sensory_box; TIGR00229
323098003120	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323098003121	putative active site [active]
323098003122	heme pocket [chemical binding]; other site
323098003123	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323098003124	dimer interface [polypeptide binding]; other site
323098003125	phosphorylation site [posttranslational modification]
323098003126	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323098003127	ATP binding site [chemical binding]; other site
323098003128	Mg2+ binding site [ion binding]; other site
323098003129	G-X-G motif; other site
323098003130	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
323098003131	FOG: CBS domain [General function prediction only]; Region: COG0517
323098003132	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
323098003133	Protein of unknown function (DUF330); Region: DUF330; cl01135
323098003134	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
323098003135	Ligand Binding Site [chemical binding]; other site
323098003136	transcriptional regulator FixK; Provisional; Region: fixK; PRK09391
323098003137	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
323098003138	ligand binding site [chemical binding]; other site
323098003139	flexible hinge region; other site
323098003140	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
323098003141	putative switch regulator; other site
323098003142	non-specific DNA interactions [nucleotide binding]; other site
323098003143	DNA binding site [nucleotide binding]
323098003144	sequence specific DNA binding site [nucleotide binding]; other site
323098003145	putative cAMP binding site [chemical binding]; other site
323098003146	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
323098003147	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
323098003148	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
323098003149	amidase catalytic site [active]
323098003150	Zn binding residues [ion binding]; other site
323098003151	substrate binding site [chemical binding]; other site
323098003152	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
323098003153	MraW methylase family; Region: Methyltransf_5; cl17771
323098003154	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
323098003155	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462
323098003156	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
323098003157	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
323098003158	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
323098003159	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
323098003160	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
323098003161	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
323098003162	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
323098003163	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093
323098003164	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
323098003165	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
323098003166	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
323098003167	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
323098003168	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
323098003169	Mg++ binding site [ion binding]; other site
323098003170	putative catalytic motif [active]
323098003171	putative substrate binding site [chemical binding]; other site
323098003172	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
323098003173	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
323098003174	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
323098003175	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
323098003176	cell division protein FtsW; Region: ftsW; TIGR02614
323098003177	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
323098003178	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
323098003179	active site
323098003180	homodimer interface [polypeptide binding]; other site
323098003181	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
323098003182	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
323098003183	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
323098003184	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
323098003185	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
323098003186	GIY-YIG motif/motif A; other site
323098003187	putative active site [active]
323098003188	putative metal binding site [ion binding]; other site
323098003189	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
323098003190	FAD binding domain; Region: FAD_binding_4; pfam01565
323098003191	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
323098003192	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
323098003193	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
323098003194	ATP-grasp domain; Region: ATP-grasp_4; cl17255
323098003195	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
323098003196	Cell division protein FtsQ; Region: FtsQ; pfam03799
323098003197	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
323098003198	Cell division protein FtsA; Region: FtsA; smart00842
323098003199	Cell division protein FtsA; Region: FtsA; pfam14450
323098003200	cell division protein FtsZ; Validated; Region: PRK09330
323098003201	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
323098003202	nucleotide binding site [chemical binding]; other site
323098003203	SulA interaction site; other site
323098003204	cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483
323098003205	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
323098003206	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
323098003207	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
323098003208	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
323098003209	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
323098003210	Walker A/P-loop; other site
323098003211	ATP binding site [chemical binding]; other site
323098003212	Q-loop/lid; other site
323098003213	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
323098003214	ABC transporter signature motif; other site
323098003215	Walker B; other site
323098003216	D-loop; other site
323098003217	H-loop/switch region; other site
323098003218	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
323098003219	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
323098003220	nucleotide binding pocket [chemical binding]; other site
323098003221	K-X-D-G motif; other site
323098003222	catalytic site [active]
323098003223	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
323098003224	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
323098003225	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
323098003226	Dimer interface [polypeptide binding]; other site
323098003227	BRCT sequence motif; other site
323098003228	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
323098003229	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
323098003230	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
323098003231	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
323098003232	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
323098003233	Walker A/P-loop; other site
323098003234	ATP binding site [chemical binding]; other site
323098003235	Q-loop/lid; other site
323098003236	ABC transporter signature motif; other site
323098003237	Walker B; other site
323098003238	D-loop; other site
323098003239	H-loop/switch region; other site
323098003240	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
323098003241	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
323098003242	NAD binding site [chemical binding]; other site
323098003243	homodimer interface [polypeptide binding]; other site
323098003244	active site
323098003245	substrate binding site [chemical binding]; other site
323098003246	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
323098003247	Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075
323098003248	putative active site [active]
323098003249	histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656
323098003250	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
323098003251	active site
323098003252	motif I; other site
323098003253	motif II; other site
323098003254	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
323098003255	dimer interface [polypeptide binding]; other site
323098003256	active site
323098003257	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
323098003258	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
323098003259	putative active site [active]
323098003260	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
323098003261	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
323098003262	NADP binding site [chemical binding]; other site
323098003263	homopentamer interface [polypeptide binding]; other site
323098003264	substrate binding site [chemical binding]; other site
323098003265	active site
323098003266	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
323098003267	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
323098003268	putative ribose interaction site [chemical binding]; other site
323098003269	putative ADP binding site [chemical binding]; other site
323098003270	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
323098003271	active site
323098003272	nucleotide binding site [chemical binding]; other site
323098003273	HIGH motif; other site
323098003274	KMSKS motif; other site
323098003275	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
323098003276	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
323098003277	NAD(P) binding site [chemical binding]; other site
323098003278	homodimer interface [polypeptide binding]; other site
323098003279	substrate binding site [chemical binding]; other site
323098003280	active site
323098003281	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
323098003282	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
323098003283	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
323098003284	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
323098003285	putative NAD(P) binding site [chemical binding]; other site
323098003286	active site
323098003287	putative substrate binding site [chemical binding]; other site
323098003288	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
323098003289	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
323098003290	Substrate binding site; other site
323098003291	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
323098003292	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
323098003293	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
323098003294	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
323098003295	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
323098003296	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
323098003297	inhibitor-cofactor binding pocket; inhibition site
323098003298	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323098003299	catalytic residue [active]
323098003300	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
323098003301	MviN-like protein; Region: MVIN; pfam03023
323098003302	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
323098003303	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
323098003304	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
323098003305	CHRD domain; Region: CHRD; pfam07452
323098003306	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
323098003307	AsnC family; Region: AsnC_trans_reg; pfam01037
323098003308	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
323098003309	dimer interface [polypeptide binding]; other site
323098003310	substrate binding site [chemical binding]; other site
323098003311	ATP binding site [chemical binding]; other site
323098003312	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
323098003313	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
323098003314	putative active site [active]
323098003315	putative metal binding site [ion binding]; other site
323098003316	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
323098003317	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
323098003318	active site
323098003319	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
323098003320	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
323098003321	catalytic loop [active]
323098003322	iron binding site [ion binding]; other site
323098003323	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
323098003324	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
323098003325	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
323098003326	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
323098003327	active site
323098003328	oxyanion hole [active]
323098003329	Predicted integral membrane protein [Function unknown]; Region: COG0392
323098003330	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
323098003331	catalytic core [active]
323098003332	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323098003333	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
323098003334	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323098003335	Winged helix-turn helix; Region: HTH_29; pfam13551
323098003336	Integrase core domain; Region: rve; pfam00665
323098003337	Integrase core domain; Region: rve_3; pfam13683
323098003338	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
323098003339	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
323098003340	flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506
323098003341	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
323098003342	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
323098003343	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12692
323098003344	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
323098003345	flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492
323098003346	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
323098003347	flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550
323098003348	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008
323098003349	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
323098003350	tyrosine decarboxylase; Region: PLN02880
323098003351	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
323098003352	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
323098003353	catalytic residue [active]
323098003354	flagellar biosynthesis repressor FlbT; Reviewed; Region: flbT; PRK12791
323098003355	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
323098003356	flagellin; Reviewed; Region: PRK12688
323098003357	flagellin; Provisional; Region: PRK14708
323098003358	flagellin; Reviewed; Region: PRK12688
323098003359	flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12794
323098003360	FlgN protein; Region: FlgN; cl09176
323098003361	chemotactic signal-response protein CheL; Provisional; Region: PRK12790
323098003362	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
323098003363	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
323098003364	flagellar assembly regulator FliX; Reviewed; Region: fliX; PRK12787
323098003365	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
323098003366	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
323098003367	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
323098003368	putative dimer interface [polypeptide binding]; other site
323098003369	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
323098003370	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
323098003371	putative dimer interface [polypeptide binding]; other site
323098003372	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
323098003373	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
323098003374	ligand binding site [chemical binding]; other site
323098003375	flexible hinge region; other site
323098003376	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
323098003377	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
323098003378	active site
323098003379	nucleophile elbow; other site
323098003380	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
323098003381	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
323098003382	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK12786
323098003383	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
323098003384	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
323098003385	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691
323098003386	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
323098003387	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
323098003388	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12689
323098003389	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
323098003390	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK12785
323098003391	flagellar motor switch protein FliM; Reviewed; Region: fliM; PRK12795
323098003392	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
323098003393	Afadin- and alpha -actinin-Binding; Region: ADIP; pfam11559
323098003394	Uncharacterized conserved protein [Function unknown]; Region: COG3334
323098003395	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
323098003396	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
323098003397	Flagellar biosynthesis protein, FliO; Region: FliO; cl01247
323098003398	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06004
323098003399	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
323098003400	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
323098003401	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
323098003402	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00732
323098003403	flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010
323098003404	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
323098003405	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
323098003406	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
323098003407	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323098003408	PAS domain; Region: PAS_9; pfam13426
323098003409	putative active site [active]
323098003410	heme pocket [chemical binding]; other site
323098003411	PAS fold; Region: PAS_4; pfam08448
323098003412	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
323098003413	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323098003414	dimer interface [polypeptide binding]; other site
323098003415	phosphorylation site [posttranslational modification]
323098003416	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323098003417	ATP binding site [chemical binding]; other site
323098003418	Mg2+ binding site [ion binding]; other site
323098003419	G-X-G motif; other site
323098003420	Response regulator receiver domain; Region: Response_reg; pfam00072
323098003421	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323098003422	active site
323098003423	phosphorylation site [posttranslational modification]
323098003424	intermolecular recognition site; other site
323098003425	dimerization interface [polypeptide binding]; other site
323098003426	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
323098003427	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
323098003428	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
323098003429	DNA binding site [nucleotide binding]
323098003430	Int/Topo IB signature motif; other site
323098003431	active site
323098003432	catalytic residues [active]
323098003433	phenylalanyl-tRNA synthetase subunit alpha; Provisional; Region: pheS; PRK04172
323098003434	Helix-turn-helix domain; Region: HTH_28; pfam13518
323098003435	putative transposase OrfB; Reviewed; Region: PHA02517
323098003436	Homeodomain-like domain; Region: HTH_32; pfam13565
323098003437	Integrase core domain; Region: rve; pfam00665
323098003438	Integrase core domain; Region: rve_3; pfam13683
323098003439	Transposase; Region: HTH_Tnp_1; pfam01527
323098003440	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323098003441	Low affinity iron permease; Region: Iron_permease; pfam04120
323098003442	Predicted integral membrane protein [Function unknown]; Region: COG5436
323098003443	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
323098003444	Transglycosylase; Region: Transgly; pfam00912
323098003445	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
323098003446	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
323098003447	hypothetical protein; Provisional; Region: PRK05170
323098003448	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
323098003449	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323098003450	putative substrate translocation pore; other site
323098003451	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
323098003452	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
323098003453	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323098003454	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323098003455	Winged helix-turn helix; Region: HTH_29; pfam13551
323098003456	Homeodomain-like domain; Region: HTH_23; cl17451
323098003457	Homeodomain-like domain; Region: HTH_32; pfam13565
323098003458	Uncharacterized conserved protein [Function unknown]; Region: COG5323
323098003459	Terminase-like family; Region: Terminase_6; pfam03237
323098003460	Phage-related protein [Function unknown]; Region: COG4695
323098003461	Phage portal protein; Region: Phage_portal; pfam04860
323098003462	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
323098003463	Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653
323098003464	Phage capsid family; Region: Phage_capsid; pfam05065
323098003465	Domain of unknown function (DUF2019); Region: DUF2019; pfam09450
323098003466	Domain of unknown function (DUF2019); Region: DUF2019; pfam09450
323098003467	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
323098003468	active site
323098003469	substrate binding sites [chemical binding]; other site
323098003470	phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215
323098003471	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
323098003472	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
323098003473	oligomerization interface [polypeptide binding]; other site
323098003474	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
323098003475	Phage major tail protein 2; Region: Phage_tail_2; cl11463
323098003476	Protein of unknown function (DUF3356); Region: DUF3356; pfam11836
323098003477	phage conserved hypothetical protein; Region: phage_TIGR02216
323098003478	Phage-related minor tail protein [Function unknown]; Region: COG5281
323098003479	Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343
323098003480	Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931
323098003481	phage conserved hypothetical protein BR0599; Region: phg_TIGR02218
323098003482	Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356
323098003483	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
323098003484	putative phage cell wall peptidase, NlpC/P60 family; Region: phage_NlpC_fam; TIGR02219
323098003485	GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547
323098003486	Putative phage tail protein; Region: Phage-tail_3; pfam13550
323098003487	Protein of unknown function (DUF2793); Region: DUF2793; pfam10983
323098003488	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
323098003489	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
323098003490	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323098003491	active site
323098003492	phosphorylation site [posttranslational modification]
323098003493	intermolecular recognition site; other site
323098003494	dimerization interface [polypeptide binding]; other site
323098003495	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
323098003496	DNA binding site [nucleotide binding]
323098003497	sensor protein PhoQ; Provisional; Region: PRK10815
323098003498	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323098003499	ATP binding site [chemical binding]; other site
323098003500	Mg2+ binding site [ion binding]; other site
323098003501	G-X-G motif; other site
323098003502	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
323098003503	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
323098003504	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
323098003505	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
323098003506	binding surface
323098003507	TPR motif; other site
323098003508	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
323098003509	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
323098003510	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
323098003511	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
323098003512	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
323098003513	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
323098003514	protein binding site [polypeptide binding]; other site
323098003515	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
323098003516	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
323098003517	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323098003518	active site
323098003519	phosphorylation site [posttranslational modification]
323098003520	intermolecular recognition site; other site
323098003521	dimerization interface [polypeptide binding]; other site
323098003522	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
323098003523	DNA binding site [nucleotide binding]
323098003524	Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835
323098003525	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
323098003526	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
323098003527	dimerization interface [polypeptide binding]; other site
323098003528	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323098003529	dimer interface [polypeptide binding]; other site
323098003530	phosphorylation site [posttranslational modification]
323098003531	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323098003532	ATP binding site [chemical binding]; other site
323098003533	Mg2+ binding site [ion binding]; other site
323098003534	G-X-G motif; other site
323098003535	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
323098003536	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
323098003537	metal binding triad; other site
323098003538	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
323098003539	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
323098003540	metal binding triad; other site
323098003541	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323098003542	PAS fold; Region: PAS_3; pfam08447
323098003543	putative active site [active]
323098003544	heme pocket [chemical binding]; other site
323098003545	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
323098003546	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323098003547	dimer interface [polypeptide binding]; other site
323098003548	phosphorylation site [posttranslational modification]
323098003549	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323098003550	ATP binding site [chemical binding]; other site
323098003551	Mg2+ binding site [ion binding]; other site
323098003552	G-X-G motif; other site
323098003553	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
323098003554	Cation efflux family; Region: Cation_efflux; cl00316
323098003555	Cation efflux family; Region: Cation_efflux; cl00316
323098003556	Cation efflux family; Region: Cation_efflux; cl00316
323098003557	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
323098003558	IHF dimer interface [polypeptide binding]; other site
323098003559	IHF - DNA interface [nucleotide binding]; other site
323098003560	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
323098003561	homodimer interface [polypeptide binding]; other site
323098003562	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
323098003563	active site pocket [active]
323098003564	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
323098003565	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
323098003566	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
323098003567	catalytic site [active]
323098003568	active site
323098003569	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
323098003570	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
323098003571	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
323098003572	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
323098003573	active site
323098003574	catalytic site [active]
323098003575	glycogen branching enzyme; Provisional; Region: PRK05402
323098003576	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
323098003577	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
323098003578	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
323098003579	active site
323098003580	catalytic site [active]
323098003581	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
323098003582	trehalose synthase; Region: treS_nterm; TIGR02456
323098003583	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
323098003584	active site
323098003585	catalytic site [active]
323098003586	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
323098003587	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
323098003588	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
323098003589	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
323098003590	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
323098003591	active site
323098003592	homodimer interface [polypeptide binding]; other site
323098003593	catalytic site [active]
323098003594	acceptor binding site [chemical binding]; other site
323098003595	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
323098003596	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
323098003597	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
323098003598	catalytic motif [active]
323098003599	Catalytic residue [active]
323098003600	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
323098003601	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323098003602	dimer interface [polypeptide binding]; other site
323098003603	phosphorylation site [posttranslational modification]
323098003604	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323098003605	ATP binding site [chemical binding]; other site
323098003606	Mg2+ binding site [ion binding]; other site
323098003607	G-X-G motif; other site
323098003608	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
323098003609	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
323098003610	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
323098003611	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
323098003612	dimer interface [polypeptide binding]; other site
323098003613	putative metal binding site [ion binding]; other site
323098003614	Domain of unknown function DUF59; Region: DUF59; pfam01883
323098003615	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
323098003616	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
323098003617	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
323098003618	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
323098003619	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
323098003620	DctM-like transporters; Region: DctM; pfam06808
323098003621	TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665
323098003622	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
323098003623	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
323098003624	FeS/SAM binding site; other site
323098003625	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
323098003626	phosphoglycolate phosphatase; Provisional; Region: PRK13222
323098003627	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
323098003628	motif II; other site
323098003629	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
323098003630	tetramer (dimer of dimers) interface [polypeptide binding]; other site
323098003631	active site
323098003632	dimer interface [polypeptide binding]; other site
323098003633	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
323098003634	glutathione reductase; Validated; Region: PRK06116
323098003635	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
323098003636	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
323098003637	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
323098003638	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
323098003639	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
323098003640	NAD synthetase; Provisional; Region: PRK13981
323098003641	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
323098003642	multimer interface [polypeptide binding]; other site
323098003643	active site
323098003644	catalytic triad [active]
323098003645	protein interface 1 [polypeptide binding]; other site
323098003646	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
323098003647	homodimer interface [polypeptide binding]; other site
323098003648	NAD binding pocket [chemical binding]; other site
323098003649	ATP binding pocket [chemical binding]; other site
323098003650	Mg binding site [ion binding]; other site
323098003651	active-site loop [active]
323098003652	Protein of unknown function (DUF2865); Region: DUF2865; pfam11064
323098003653	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
323098003654	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
323098003655	active site
323098003656	HIGH motif; other site
323098003657	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
323098003658	KMSKS motif; other site
323098003659	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
323098003660	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
323098003661	putative active site [active]
323098003662	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
323098003663	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
323098003664	Coenzyme A binding pocket [chemical binding]; other site
323098003665	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
323098003666	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
323098003667	active site
323098003668	catalytic residues [active]
323098003669	metal binding site [ion binding]; metal-binding site
323098003670	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
323098003671	Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
323098003672	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
323098003673	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
323098003674	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
323098003675	Walker A/P-loop; other site
323098003676	ATP binding site [chemical binding]; other site
323098003677	Q-loop/lid; other site
323098003678	ABC transporter signature motif; other site
323098003679	Walker B; other site
323098003680	D-loop; other site
323098003681	H-loop/switch region; other site
323098003682	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
323098003683	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
323098003684	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
323098003685	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
323098003686	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
323098003687	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
323098003688	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
323098003689	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
323098003690	ligand binding site [chemical binding]; other site
323098003691	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
323098003692	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
323098003693	active site residue [active]
323098003694	hypothetical protein; Provisional; Region: PRK08912
323098003695	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
323098003696	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323098003697	homodimer interface [polypeptide binding]; other site
323098003698	catalytic residue [active]
323098003699	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
323098003700	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
323098003701	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
323098003702	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
323098003703	putative acyl-acceptor binding pocket; other site
323098003704	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501
323098003705	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
323098003706	dimer interface [polypeptide binding]; other site
323098003707	active site
323098003708	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519
323098003709	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
323098003710	active site
323098003711	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
323098003712	acyl carrier protein; Provisional; Region: PRK06508
323098003713	HerA helicase [Replication, recombination, and repair]; Region: COG0433
323098003714	Domain of unknown function DUF87; Region: DUF87; pfam01935
323098003715	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
323098003716	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
323098003717	catalytic residues [active]
323098003718	catalytic nucleophile [active]
323098003719	Recombinase; Region: Recombinase; pfam07508
323098003720	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
323098003721	putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/unknown domain fusion protein; Provisional; Region: PRK14495
323098003722	HNH endonuclease; Region: HNH_2; pfam13391
323098003723	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
323098003724	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
323098003725	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
323098003726	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
323098003727	HsdM N-terminal domain; Region: HsdM_N; pfam12161
323098003728	Methyltransferase domain; Region: Methyltransf_26; pfam13659
323098003729	DNA methylase; Region: N6_N4_Mtase; cl17433
323098003730	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
323098003731	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
323098003732	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
323098003733	ATP binding site [chemical binding]; other site
323098003734	putative Mg++ binding site [ion binding]; other site
323098003735	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
323098003736	nucleotide binding region [chemical binding]; other site
323098003737	ATP-binding site [chemical binding]; other site
323098003738	CHC2 zinc finger; Region: zf-CHC2; cl17510
323098003739	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
323098003740	active site
323098003741	metal binding site [ion binding]; metal-binding site
323098003742	interdomain interaction site; other site
323098003743	Domain of unknown function (DUF955); Region: DUF955; pfam06114
323098003744	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
323098003745	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
323098003746	sequence-specific DNA binding site [nucleotide binding]; other site
323098003747	salt bridge; other site
323098003748	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
323098003749	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
323098003750	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
323098003751	HlyD family secretion protein; Region: HlyD_3; pfam13437
323098003752	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
323098003753	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
323098003754	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
323098003755	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
323098003756	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
323098003757	Peptidase family M50; Region: Peptidase_M50; pfam02163
323098003758	active site
323098003759	putative substrate binding region [chemical binding]; other site
323098003760	Cupin-like domain; Region: Cupin_8; pfam13621
323098003761	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
323098003762	Caspase domain; Region: Peptidase_C14; pfam00656
323098003763	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
323098003764	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
323098003765	recombinase A; Provisional; Region: recA; PRK09354
323098003766	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
323098003767	hexamer interface [polypeptide binding]; other site
323098003768	Walker A motif; other site
323098003769	ATP binding site [chemical binding]; other site
323098003770	Walker B motif; other site
323098003771	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323098003772	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
323098003773	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323098003774	glycine dehydrogenase; Provisional; Region: PRK05367
323098003775	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
323098003776	tetramer interface [polypeptide binding]; other site
323098003777	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323098003778	catalytic residue [active]
323098003779	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
323098003780	tetramer interface [polypeptide binding]; other site
323098003781	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323098003782	catalytic residue [active]
323098003783	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
323098003784	lipoyl attachment site [posttranslational modification]; other site
323098003785	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
323098003786	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
323098003787	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
323098003788	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
323098003789	motif 1; other site
323098003790	active site
323098003791	motif 2; other site
323098003792	motif 3; other site
323098003793	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
323098003794	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323098003795	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
323098003796	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323098003797	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323098003798	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323098003799	Winged helix-turn helix; Region: HTH_29; pfam13551
323098003800	Integrase core domain; Region: rve; pfam00665
323098003801	Integrase core domain; Region: rve_3; pfam13683
323098003802	isocitrate dehydrogenase; Validated; Region: PRK08299
323098003803	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
323098003804	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
323098003805	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
323098003806	putative active site [active]
323098003807	Winged helix-turn helix; Region: HTH_29; pfam13551
323098003808	Integrase core domain; Region: rve; pfam00665
323098003809	Integrase core domain; Region: rve_3; pfam13683
323098003810	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323098003811	Transposase; Region: HTH_Tnp_1; pfam01527
323098003812	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323098003813	Helix-turn-helix domain; Region: HTH_28; pfam13518
323098003814	Winged helix-turn helix; Region: HTH_29; pfam13551
323098003815	Homeodomain-like domain; Region: HTH_32; pfam13565
323098003816	Integrase core domain; Region: rve; pfam00665
323098003817	Integrase core domain; Region: rve_3; pfam13683
323098003818	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
323098003819	ADP-ribose binding site [chemical binding]; other site
323098003820	cyanate hydratase; Validated; Region: PRK02866
323098003821	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
323098003822	oligomer interface [polypeptide binding]; other site
323098003823	active site
323098003824	Domain of unknown function (DUF1476); Region: DUF1476; pfam07345
323098003825	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
323098003826	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
323098003827	ATP binding site [chemical binding]; other site
323098003828	active site
323098003829	substrate binding site [chemical binding]; other site
323098003830	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
323098003831	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
323098003832	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
323098003833	putative active site [active]
323098003834	catalytic triad [active]
323098003835	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
323098003836	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
323098003837	dimerization interface [polypeptide binding]; other site
323098003838	ATP binding site [chemical binding]; other site
323098003839	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
323098003840	dimerization interface [polypeptide binding]; other site
323098003841	ATP binding site [chemical binding]; other site
323098003842	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
323098003843	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
323098003844	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
323098003845	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
323098003846	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
323098003847	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
323098003848	putative GSH binding site [chemical binding]; other site
323098003849	catalytic residues [active]
323098003850	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
323098003851	Winged helix-turn helix; Region: HTH_29; pfam13551
323098003852	Homeodomain-like domain; Region: HTH_23; cl17451
323098003853	Homeodomain-like domain; Region: HTH_32; pfam13565
323098003854	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323098003855	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323098003856	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
323098003857	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
323098003858	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
323098003859	RNA binding surface [nucleotide binding]; other site
323098003860	glutamate racemase; Provisional; Region: PRK00865
323098003861	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388
323098003862	PAS domain; Region: PAS_5; pfam07310
323098003863	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
323098003864	FOG: CBS domain [General function prediction only]; Region: COG0517
323098003865	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323098003866	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
323098003867	hypothetical protein; Provisional; Region: PRK10279
323098003868	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
323098003869	nucleophile elbow; other site
323098003870	hypothetical protein; Validated; Region: PRK00041
323098003871	Predicted periplasmic protein [Function unknown]; Region: COG3904
323098003872	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
323098003873	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
323098003874	trimerization site [polypeptide binding]; other site
323098003875	active site
323098003876	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
323098003877	GTP cyclohydrolase I; Provisional; Region: PLN03044
323098003878	active site
323098003879	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
323098003880	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
323098003881	N-acetyl-D-glucosamine binding site [chemical binding]; other site
323098003882	catalytic residue [active]
323098003883	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
323098003884	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
323098003885	putative binding surface; other site
323098003886	active site
323098003887	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
323098003888	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323098003889	active site
323098003890	phosphorylation site [posttranslational modification]
323098003891	intermolecular recognition site; other site
323098003892	dimerization interface [polypeptide binding]; other site
323098003893	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
323098003894	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
323098003895	Secretin and TonB N terminus short domain; Region: STN; smart00965
323098003896	ferrichrome receptor precursor protein; Provisional; Region: PRK14050
323098003897	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
323098003898	N-terminal plug; other site
323098003899	ligand-binding site [chemical binding]; other site
323098003900	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
323098003901	FecR protein; Region: FecR; pfam04773
323098003902	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
323098003903	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
323098003904	DNA binding residues [nucleotide binding]
323098003905	PRC-barrel domain; Region: PRC; pfam05239
323098003906	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
323098003907	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
323098003908	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
323098003909	putative homodimer interface [polypeptide binding]; other site
323098003910	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
323098003911	heterodimer interface [polypeptide binding]; other site
323098003912	homodimer interface [polypeptide binding]; other site
323098003913	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
323098003914	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
323098003915	23S rRNA interface [nucleotide binding]; other site
323098003916	L7/L12 interface [polypeptide binding]; other site
323098003917	putative thiostrepton binding site; other site
323098003918	L25 interface [polypeptide binding]; other site
323098003919	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
323098003920	mRNA/rRNA interface [nucleotide binding]; other site
323098003921	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
323098003922	23S rRNA interface [nucleotide binding]; other site
323098003923	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
323098003924	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
323098003925	L11 interface [polypeptide binding]; other site
323098003926	putative EF-Tu interaction site [polypeptide binding]; other site
323098003927	putative EF-G interaction site [polypeptide binding]; other site
323098003928	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
323098003929	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
323098003930	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
323098003931	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
323098003932	RPB11 interaction site [polypeptide binding]; other site
323098003933	RPB12 interaction site [polypeptide binding]; other site
323098003934	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
323098003935	RPB3 interaction site [polypeptide binding]; other site
323098003936	RPB1 interaction site [polypeptide binding]; other site
323098003937	RPB11 interaction site [polypeptide binding]; other site
323098003938	RPB10 interaction site [polypeptide binding]; other site
323098003939	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
323098003940	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
323098003941	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
323098003942	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
323098003943	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
323098003944	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
323098003945	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
323098003946	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
323098003947	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
323098003948	DNA binding site [nucleotide binding]
323098003949	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
323098003950	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
323098003951	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
323098003952	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
323098003953	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
323098003954	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
323098003955	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
323098003956	ligand binding site [chemical binding]; other site
323098003957	flexible hinge region; other site
323098003958	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
323098003959	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323098003960	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
323098003961	S17 interaction site [polypeptide binding]; other site
323098003962	S8 interaction site; other site
323098003963	16S rRNA interaction site [nucleotide binding]; other site
323098003964	streptomycin interaction site [chemical binding]; other site
323098003965	23S rRNA interaction site [nucleotide binding]; other site
323098003966	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
323098003967	30S ribosomal protein S7; Validated; Region: PRK05302
323098003968	elongation factor G; Reviewed; Region: PRK00007
323098003969	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
323098003970	G1 box; other site
323098003971	putative GEF interaction site [polypeptide binding]; other site
323098003972	GTP/Mg2+ binding site [chemical binding]; other site
323098003973	Switch I region; other site
323098003974	G2 box; other site
323098003975	G3 box; other site
323098003976	Switch II region; other site
323098003977	G4 box; other site
323098003978	G5 box; other site
323098003979	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
323098003980	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
323098003981	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
323098003982	elongation factor Tu; Reviewed; Region: PRK00049
323098003983	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
323098003984	G1 box; other site
323098003985	GEF interaction site [polypeptide binding]; other site
323098003986	GTP/Mg2+ binding site [chemical binding]; other site
323098003987	Switch I region; other site
323098003988	G2 box; other site
323098003989	G3 box; other site
323098003990	Switch II region; other site
323098003991	G4 box; other site
323098003992	G5 box; other site
323098003993	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
323098003994	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
323098003995	Antibiotic Binding Site [chemical binding]; other site
323098003996	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
323098003997	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
323098003998	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
323098003999	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
323098004000	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
323098004001	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
323098004002	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
323098004003	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
323098004004	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
323098004005	putative translocon binding site; other site
323098004006	protein-rRNA interface [nucleotide binding]; other site
323098004007	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
323098004008	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
323098004009	G-X-X-G motif; other site
323098004010	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
323098004011	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
323098004012	23S rRNA interface [nucleotide binding]; other site
323098004013	5S rRNA interface [nucleotide binding]; other site
323098004014	putative antibiotic binding site [chemical binding]; other site
323098004015	L25 interface [polypeptide binding]; other site
323098004016	L27 interface [polypeptide binding]; other site
323098004017	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
323098004018	23S rRNA interface [nucleotide binding]; other site
323098004019	putative translocon interaction site; other site
323098004020	signal recognition particle (SRP54) interaction site; other site
323098004021	L23 interface [polypeptide binding]; other site
323098004022	trigger factor interaction site; other site
323098004023	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
323098004024	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
323098004025	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
323098004026	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
323098004027	RNA binding site [nucleotide binding]; other site
323098004028	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
323098004029	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
323098004030	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
323098004031	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
323098004032	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
323098004033	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
323098004034	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
323098004035	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
323098004036	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
323098004037	5S rRNA interface [nucleotide binding]; other site
323098004038	23S rRNA interface [nucleotide binding]; other site
323098004039	L5 interface [polypeptide binding]; other site
323098004040	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
323098004041	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
323098004042	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
323098004043	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
323098004044	23S rRNA binding site [nucleotide binding]; other site
323098004045	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
323098004046	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
323098004047	SecY translocase; Region: SecY; pfam00344
323098004048	adenylate kinase; Reviewed; Region: adk; PRK00279
323098004049	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
323098004050	AMP-binding site [chemical binding]; other site
323098004051	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
323098004052	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
323098004053	30S ribosomal protein S13; Region: bact_S13; TIGR03631
323098004054	30S ribosomal protein S11; Validated; Region: PRK05309
323098004055	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
323098004056	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
323098004057	alphaNTD - beta interaction site [polypeptide binding]; other site
323098004058	alphaNTD homodimer interface [polypeptide binding]; other site
323098004059	alphaNTD - beta' interaction site [polypeptide binding]; other site
323098004060	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
323098004061	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
323098004062	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
323098004063	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
323098004064	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
323098004065	protein binding site [polypeptide binding]; other site
323098004066	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
323098004067	protein binding site [polypeptide binding]; other site
323098004068	recombination factor protein RarA; Reviewed; Region: PRK13342
323098004069	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323098004070	Walker A motif; other site
323098004071	ATP binding site [chemical binding]; other site
323098004072	Walker B motif; other site
323098004073	arginine finger; other site
323098004074	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
323098004075	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
323098004076	binding surface
323098004077	TPR motif; other site
323098004078	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
323098004079	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
323098004080	RNA binding surface [nucleotide binding]; other site
323098004081	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
323098004082	active site
323098004083	Winged helix-turn helix; Region: HTH_29; pfam13551
323098004084	Homeodomain-like domain; Region: HTH_23; cl17451
323098004085	Homeodomain-like domain; Region: HTH_32; pfam13565
323098004086	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323098004087	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323098004088	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323098004089	ATP12 chaperone protein; Region: ATP12; cl02228
323098004090	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
323098004091	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
323098004092	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
323098004093	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
323098004094	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
323098004095	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
323098004096	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
323098004097	Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; pfam03981
323098004098	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
323098004099	putative phosphate acyltransferase; Provisional; Region: PRK05331
323098004100	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
323098004101	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
323098004102	dimer interface [polypeptide binding]; other site
323098004103	active site
323098004104	CoA binding pocket [chemical binding]; other site
323098004105	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
323098004106	IHF dimer interface [polypeptide binding]; other site
323098004107	IHF - DNA interface [nucleotide binding]; other site
323098004108	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
323098004109	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
323098004110	DNA binding residues [nucleotide binding]
323098004111	Uncharacterized conserved protein [Function unknown]; Region: COG3268
323098004112	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323098004113	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
323098004114	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
323098004115	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
323098004116	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
323098004117	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
323098004118	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
323098004119	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
323098004120	SLBB domain; Region: SLBB; pfam10531
323098004121	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
323098004122	Chain length determinant protein; Region: Wzz; pfam02706
323098004123	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
323098004124	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
323098004125	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
323098004126	Protein of unknown function (DUF2842); Region: DUF2842; pfam11003
323098004127	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
323098004128	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
323098004129	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
323098004130	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323098004131	putative substrate translocation pore; other site
323098004132	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994
323098004133	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
323098004134	homodimer interface [polypeptide binding]; other site
323098004135	substrate-cofactor binding pocket; other site
323098004136	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323098004137	catalytic residue [active]
323098004138	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
323098004139	23S rRNA interface [nucleotide binding]; other site
323098004140	L3 interface [polypeptide binding]; other site
323098004141	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
323098004142	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
323098004143	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
323098004144	N-acetyl-D-glucosamine binding site [chemical binding]; other site
323098004145	catalytic residue [active]
323098004146	Sporulation related domain; Region: SPOR; pfam05036
323098004147	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
323098004148	homodimer interaction site [polypeptide binding]; other site
323098004149	cofactor binding site; other site
323098004150	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146
323098004151	Protein of unknown function, DUF482; Region: DUF482; pfam04339
323098004152	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_3; cd08585
323098004153	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
323098004154	putative active site [active]
323098004155	catalytic site [active]
323098004156	putative metal binding site [ion binding]; other site
323098004157	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
323098004158	homotrimer interaction site [polypeptide binding]; other site
323098004159	putative active site [active]
323098004160	Domain of unknown function (DUF1849); Region: DUF1849; pfam08904
323098004161	DNA polymerase IV; Provisional; Region: PRK02794
323098004162	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
323098004163	active site
323098004164	DNA binding site [nucleotide binding]
323098004165	Protein of unknown function (DUF3572); Region: DUF3572; pfam12096
323098004166	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
323098004167	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323098004168	active site
323098004169	phosphorylation site [posttranslational modification]
323098004170	intermolecular recognition site; other site
323098004171	dimerization interface [polypeptide binding]; other site
323098004172	response regulator PleD; Reviewed; Region: pleD; PRK09581
323098004173	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323098004174	active site
323098004175	phosphorylation site [posttranslational modification]
323098004176	intermolecular recognition site; other site
323098004177	dimerization interface [polypeptide binding]; other site
323098004178	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323098004179	active site
323098004180	phosphorylation site [posttranslational modification]
323098004181	intermolecular recognition site; other site
323098004182	dimerization interface [polypeptide binding]; other site
323098004183	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
323098004184	metal binding site [ion binding]; metal-binding site
323098004185	active site
323098004186	I-site; other site
323098004187	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
323098004188	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
323098004189	Protein of unknown function (DUF2497); Region: DUF2497; pfam10691
323098004190	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
323098004191	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
323098004192	HIGH motif; other site
323098004193	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
323098004194	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
323098004195	active site
323098004196	KMSKS motif; other site
323098004197	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
323098004198	tRNA binding surface [nucleotide binding]; other site
323098004199	anticodon binding site; other site
323098004200	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
323098004201	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
323098004202	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
323098004203	DNA binding site [nucleotide binding]
323098004204	active site
323098004205	lipoyl synthase; Provisional; Region: PRK05481
323098004206	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
323098004207	FeS/SAM binding site; other site
323098004208	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
323098004209	putative coenzyme Q binding site [chemical binding]; other site
323098004210	Competence-damaged protein; Region: CinA; pfam02464
323098004211	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
323098004212	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
323098004213	substrate binding site; other site
323098004214	dimer interface; other site
323098004215	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
323098004216	homotrimer interaction site [polypeptide binding]; other site
323098004217	zinc binding site [ion binding]; other site
323098004218	CDP-binding sites; other site
323098004219	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
323098004220	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
323098004221	FMN binding site [chemical binding]; other site
323098004222	active site
323098004223	catalytic residues [active]
323098004224	substrate binding site [chemical binding]; other site
323098004225	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
323098004226	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323098004227	putative active site [active]
323098004228	heme pocket [chemical binding]; other site
323098004229	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323098004230	dimer interface [polypeptide binding]; other site
323098004231	phosphorylation site [posttranslational modification]
323098004232	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323098004233	ATP binding site [chemical binding]; other site
323098004234	Mg2+ binding site [ion binding]; other site
323098004235	G-X-G motif; other site
323098004236	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
323098004237	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323098004238	active site
323098004239	phosphorylation site [posttranslational modification]
323098004240	intermolecular recognition site; other site
323098004241	dimerization interface [polypeptide binding]; other site
323098004242	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323098004243	Walker A motif; other site
323098004244	ATP binding site [chemical binding]; other site
323098004245	Walker B motif; other site
323098004246	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
323098004247	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
323098004248	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
323098004249	dimerization interface [polypeptide binding]; other site
323098004250	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323098004251	putative active site [active]
323098004252	heme pocket [chemical binding]; other site
323098004253	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323098004254	dimer interface [polypeptide binding]; other site
323098004255	phosphorylation site [posttranslational modification]
323098004256	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323098004257	ATP binding site [chemical binding]; other site
323098004258	G-X-G motif; other site
323098004259	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
323098004260	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323098004261	active site
323098004262	phosphorylation site [posttranslational modification]
323098004263	intermolecular recognition site; other site
323098004264	dimerization interface [polypeptide binding]; other site
323098004265	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323098004266	Walker A motif; other site
323098004267	ATP binding site [chemical binding]; other site
323098004268	Walker B motif; other site
323098004269	arginine finger; other site
323098004270	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
323098004271	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
323098004272	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
323098004273	homodimer interface [polypeptide binding]; other site
323098004274	substrate-cofactor binding pocket; other site
323098004275	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323098004276	catalytic residue [active]
323098004277	bacterial Hfq-like; Region: Hfq; cd01716
323098004278	hexamer interface [polypeptide binding]; other site
323098004279	Sm1 motif; other site
323098004280	RNA binding site [nucleotide binding]; other site
323098004281	Sm2 motif; other site
323098004282	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
323098004283	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
323098004284	HflX GTPase family; Region: HflX; cd01878
323098004285	G1 box; other site
323098004286	GTP/Mg2+ binding site [chemical binding]; other site
323098004287	Switch I region; other site
323098004288	G2 box; other site
323098004289	G3 box; other site
323098004290	Switch II region; other site
323098004291	G4 box; other site
323098004292	G5 box; other site
323098004293	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
323098004294	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
323098004295	tetramerization interface [polypeptide binding]; other site
323098004296	NAD(P) binding site [chemical binding]; other site
323098004297	catalytic residues [active]
323098004298	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
323098004299	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
323098004300	homodimer interface [polypeptide binding]; other site
323098004301	metal binding site [ion binding]; metal-binding site
323098004302	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
323098004303	homodimer interface [polypeptide binding]; other site
323098004304	active site
323098004305	putative chemical substrate binding site [chemical binding]; other site
323098004306	metal binding site [ion binding]; metal-binding site
323098004307	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
323098004308	Ligand Binding Site [chemical binding]; other site
323098004309	Outer membrane efflux protein; Region: OEP; pfam02321
323098004310	Outer membrane efflux protein; Region: OEP; pfam02321
323098004311	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
323098004312	lipoyl-biotinyl attachment site [posttranslational modification]; other site
323098004313	HlyD family secretion protein; Region: HlyD_3; pfam13437
323098004314	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
323098004315	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
323098004316	Uncharacterized conserved protein [Function unknown]; Region: COG1742
323098004317	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
323098004318	putative hydrolase; Provisional; Region: PRK02113
323098004319	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
323098004320	active site
323098004321	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
323098004322	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
323098004323	active site
323098004324	HIGH motif; other site
323098004325	KMSKS motif; other site
323098004326	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
323098004327	tRNA binding surface [nucleotide binding]; other site
323098004328	anticodon binding site; other site
323098004329	DNA polymerase III subunit delta'; Validated; Region: PRK07471
323098004330	AAA ATPase domain; Region: AAA_16; pfam13191
323098004331	DNA polymerase III subunit delta'; Validated; Region: PRK08485
323098004332	thymidylate kinase; Region: DTMP_kinase; TIGR00041
323098004333	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
323098004334	TMP-binding site; other site
323098004335	ATP-binding site [chemical binding]; other site
323098004336	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
323098004337	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
323098004338	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
323098004339	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
323098004340	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
323098004341	PilZ domain; Region: PilZ; pfam07238
323098004342	tape measure domain; Region: tape_meas_nterm; TIGR02675
323098004343	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
323098004344	Phage Terminase; Region: Terminase_1; pfam03354
323098004345	Phage terminase, small subunit; Region: Terminase_4; pfam05119
323098004346	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
323098004347	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
323098004348	Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883
323098004349	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
323098004350	oligomerization interface [polypeptide binding]; other site
323098004351	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
323098004352	active site
323098004353	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
323098004354	Phage capsid family; Region: Phage_capsid; pfam05065
323098004355	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
323098004356	Phage-related protein [Function unknown]; Region: COG4695; cl01923
323098004357	Phage portal protein; Region: Phage_portal; pfam04860
323098004358	RecA-family ATPase [DNA replication, recombination, and repair]; Region: RepA; COG3598
323098004359	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
323098004360	Walker A motif; other site
323098004361	ATP binding site [chemical binding]; other site
323098004362	Walker B motif; other site
323098004363	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
323098004364	Int/Topo IB signature motif; other site
323098004365	Transposase; Region: HTH_Tnp_1; pfam01527
323098004366	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323098004367	Helix-turn-helix domain; Region: HTH_28; pfam13518
323098004368	Winged helix-turn helix; Region: HTH_29; pfam13551
323098004369	Homeodomain-like domain; Region: HTH_32; pfam13565
323098004370	Integrase core domain; Region: rve; pfam00665
323098004371	Integrase core domain; Region: rve_3; pfam13683
323098004372	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
323098004373	active site
323098004374	metal binding site [ion binding]; metal-binding site
323098004375	interdomain interaction site; other site
323098004376	AAA domain; Region: AAA_25; pfam13481
323098004377	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
323098004378	Walker A motif; other site
323098004379	ATP binding site [chemical binding]; other site
323098004380	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
323098004381	active site
323098004382	Int/Topo IB signature motif; other site
323098004383	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
323098004384	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
323098004385	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
323098004386	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
323098004387	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
323098004388	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
323098004389	putative active site [active]
323098004390	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
323098004391	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
323098004392	NADP binding site [chemical binding]; other site
323098004393	dimer interface [polypeptide binding]; other site
323098004394	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
323098004395	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
323098004396	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494
323098004397	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
323098004398	Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755
323098004399	Invasion associated locus B (IalB) protein; Region: IalB; pfam06776
323098004400	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
323098004401	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
323098004402	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
323098004403	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
323098004404	acyl-activating enzyme (AAE) consensus motif; other site
323098004405	active site
323098004406	AMP binding site [chemical binding]; other site
323098004407	CoA binding site [chemical binding]; other site
323098004408	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
323098004409	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
323098004410	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
323098004411	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
323098004412	ATP binding site [chemical binding]; other site
323098004413	putative Mg++ binding site [ion binding]; other site
323098004414	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
323098004415	nucleotide binding region [chemical binding]; other site
323098004416	ATP-binding site [chemical binding]; other site
323098004417	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
323098004418	Uncharacterized conserved protein [Function unknown]; Region: COG2938
323098004419	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
323098004420	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
323098004421	generic binding surface II; other site
323098004422	ssDNA binding site; other site
323098004423	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
323098004424	ATP binding site [chemical binding]; other site
323098004425	putative Mg++ binding site [ion binding]; other site
323098004426	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
323098004427	nucleotide binding region [chemical binding]; other site
323098004428	ATP-binding site [chemical binding]; other site
323098004429	Uncharacterized conserved protein [Function unknown]; Region: COG2928
323098004430	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
323098004431	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
323098004432	glutaminase active site [active]
323098004433	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
323098004434	dimer interface [polypeptide binding]; other site
323098004435	active site
323098004436	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
323098004437	dimer interface [polypeptide binding]; other site
323098004438	active site
323098004439	DTW domain; Region: DTW; cl01221
323098004440	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
323098004441	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
323098004442	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
323098004443	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
323098004444	HlyD family secretion protein; Region: HlyD_3; pfam13437
323098004445	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
323098004446	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
323098004447	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
323098004448	dimer interface [polypeptide binding]; other site
323098004449	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323098004450	catalytic residue [active]
323098004451	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
323098004452	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
323098004453	Walker A/P-loop; other site
323098004454	ATP binding site [chemical binding]; other site
323098004455	Q-loop/lid; other site
323098004456	ABC transporter signature motif; other site
323098004457	Walker B; other site
323098004458	D-loop; other site
323098004459	H-loop/switch region; other site
323098004460	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
323098004461	dimer interface [polypeptide binding]; other site
323098004462	conserved gate region; other site
323098004463	putative PBP binding loops; other site
323098004464	ABC-ATPase subunit interface; other site
323098004465	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
323098004466	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
323098004467	conserved gate region; other site
323098004468	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
323098004469	dimer interface [polypeptide binding]; other site
323098004470	conserved gate region; other site
323098004471	putative PBP binding loops; other site
323098004472	ABC-ATPase subunit interface; other site
323098004473	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
323098004474	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
323098004475	substrate binding pocket [chemical binding]; other site
323098004476	membrane-bound complex binding site; other site
323098004477	hinge residues; other site
323098004478	cystathionine beta-lyase; Provisional; Region: PRK05967
323098004479	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
323098004480	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
323098004481	catalytic residue [active]
323098004482	Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627
323098004483	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
323098004484	Ligand binding site; other site
323098004485	Putative Catalytic site; other site
323098004486	DXD motif; other site
323098004487	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
323098004488	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
323098004489	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953
323098004490	Transglycosylase; Region: Transgly; pfam00912
323098004491	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
323098004492	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
323098004493	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
323098004494	MG2 domain; Region: A2M_N; pfam01835
323098004495	Alpha-2-macroglobulin family; Region: A2M; pfam00207
323098004496	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
323098004497	surface patch; other site
323098004498	thioester region; other site
323098004499	specificity defining residues; other site
323098004500	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
323098004501	Helix-turn-helix domain; Region: HTH_28; pfam13518
323098004502	putative transposase OrfB; Reviewed; Region: PHA02517
323098004503	Homeodomain-like domain; Region: HTH_32; pfam13565
323098004504	Integrase core domain; Region: rve; pfam00665
323098004505	Integrase core domain; Region: rve_3; pfam13683
323098004506	Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653
323098004507	Phage capsid family; Region: Phage_capsid; pfam05065
323098004508	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
323098004509	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
323098004510	oligomer interface [polypeptide binding]; other site
323098004511	active site residues [active]
323098004512	Phage-related protein [Function unknown]; Region: COG4695
323098004513	Phage portal protein; Region: Phage_portal; pfam04860
323098004514	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
323098004515	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
323098004516	ParB-like nuclease domain; Region: ParBc; pfam02195
323098004517	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
323098004518	DNA methylase; Region: N6_N4_Mtase; pfam01555
323098004519	Phage terminase, small subunit; Region: Terminase_4; cl01525
323098004520	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
323098004521	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895
323098004522	Transcription antiterminator [Transcription]; Region: NusG; COG0250
323098004523	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
323098004524	heterodimer interface [polypeptide binding]; other site
323098004525	homodimer interface [polypeptide binding]; other site
323098004526	Helix-turn-helix domain; Region: HTH_36; pfam13730
323098004527	ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain...; Region: ASCH_ASC-1_like; cd06554
323098004528	MT-A70; Region: MT-A70; cl01947
323098004529	HNH endonuclease; Region: HNH_3; pfam13392
323098004530	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073
323098004531	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
323098004532	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
323098004533	active site
323098004534	DNA binding site [nucleotide binding]
323098004535	Int/Topo IB signature motif; other site
323098004536	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
323098004537	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
323098004538	dimer interface [polypeptide binding]; other site
323098004539	ssDNA binding site [nucleotide binding]; other site
323098004540	tetramer (dimer of dimers) interface [polypeptide binding]; other site
323098004541	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
323098004542	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
323098004543	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
323098004544	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
323098004545	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
323098004546	BA14K-like protein; Region: BA14K; pfam07886
323098004547	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562
323098004548	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
323098004549	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
323098004550	Transcriptional regulator; Region: Transcrip_reg; cl00361
323098004551	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
323098004552	active site
323098004553	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
323098004554	TSCPD domain; Region: TSCPD; pfam12637
323098004555	putative transposase OrfB; Reviewed; Region: PHA02517
323098004556	HTH-like domain; Region: HTH_21; pfam13276
323098004557	Integrase core domain; Region: rve; pfam00665
323098004558	Integrase core domain; Region: rve_3; pfam13683
323098004559	Transposase; Region: HTH_Tnp_1; cl17663
323098004560	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
323098004561	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
323098004562	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
323098004563	nucleotide binding site [chemical binding]; other site
323098004564	putative S-transferase; Provisional; Region: PRK11752
323098004565	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
323098004566	C-terminal domain interface [polypeptide binding]; other site
323098004567	GSH binding site (G-site) [chemical binding]; other site
323098004568	dimer interface [polypeptide binding]; other site
323098004569	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
323098004570	dimer interface [polypeptide binding]; other site
323098004571	N-terminal domain interface [polypeptide binding]; other site
323098004572	active site
323098004573	short chain dehydrogenase; Provisional; Region: PRK12828
323098004574	dihydropteridine reductase (DHPR), classical (c) SDRs; Region: DHPR_SDR_c_like; cd05334
323098004575	NAD binding site [chemical binding]; other site
323098004576	homodimer interface [polypeptide binding]; other site
323098004577	active site
323098004578	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
323098004579	active site 1 [active]
323098004580	dimer interface [polypeptide binding]; other site
323098004581	active site 2 [active]
323098004582	Uncharacterized conserved protein [Function unknown]; Region: COG5482
323098004583	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045
323098004584	CreA protein; Region: CreA; pfam05981
323098004585	hypothetical protein; Provisional; Region: PRK06132
323098004586	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
323098004587	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
323098004588	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
323098004589	NodB motif; other site
323098004590	active site
323098004591	catalytic site [active]
323098004592	metal binding site [ion binding]; metal-binding site
323098004593	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426
323098004594	folate binding site [chemical binding]; other site
323098004595	NADP+ binding site [chemical binding]; other site
323098004596	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
323098004597	Malic enzyme, N-terminal domain; Region: malic; pfam00390
323098004598	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
323098004599	putative NAD(P) binding site [chemical binding]; other site
323098004600	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
323098004601	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
323098004602	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
323098004603	dimer interface [polypeptide binding]; other site
323098004604	anticodon binding site; other site
323098004605	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
323098004606	homodimer interface [polypeptide binding]; other site
323098004607	motif 1; other site
323098004608	active site
323098004609	motif 2; other site
323098004610	GAD domain; Region: GAD; pfam02938
323098004611	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
323098004612	active site
323098004613	motif 3; other site
323098004614	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
323098004615	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
323098004616	catalytic site [active]
323098004617	putative active site [active]
323098004618	putative substrate binding site [chemical binding]; other site
323098004619	HRDC domain; Region: HRDC; pfam00570
323098004620	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
323098004621	Domain of unknown function DUF21; Region: DUF21; pfam01595
323098004622	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
323098004623	Transporter associated domain; Region: CorC_HlyC; smart01091
323098004624	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323098004625	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323098004626	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
323098004627	exopolyphosphatase; Region: exo_poly_only; TIGR03706
323098004628	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
323098004629	polyphosphate kinase; Provisional; Region: PRK05443
323098004630	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
323098004631	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
323098004632	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
323098004633	putative domain interface [polypeptide binding]; other site
323098004634	putative active site [active]
323098004635	catalytic site [active]
323098004636	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
323098004637	putative domain interface [polypeptide binding]; other site
323098004638	putative active site [active]
323098004639	catalytic site [active]
323098004640	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
323098004641	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
323098004642	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
323098004643	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
323098004644	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
323098004645	dimerization interface [polypeptide binding]; other site
323098004646	putative ATP binding site [chemical binding]; other site
323098004647	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
323098004648	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
323098004649	active site
323098004650	substrate binding site [chemical binding]; other site
323098004651	cosubstrate binding site; other site
323098004652	catalytic site [active]
323098004653	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
323098004654	DNA-binding site [nucleotide binding]; DNA binding site
323098004655	RNA-binding motif; other site
323098004656	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
323098004657	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
323098004658	active site
323098004659	multimer interface [polypeptide binding]; other site
323098004660	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
323098004661	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
323098004662	ATP-grasp domain; Region: ATP-grasp_4; cl17255
323098004663	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
323098004664	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
323098004665	carboxyltransferase (CT) interaction site; other site
323098004666	biotinylation site [posttranslational modification]; other site
323098004667	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
323098004668	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
323098004669	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
323098004670	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
323098004671	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
323098004672	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
323098004673	DNA-binding site [nucleotide binding]; DNA binding site
323098004674	RNA-binding motif; other site
323098004675	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
323098004676	DNA-binding site [nucleotide binding]; DNA binding site
323098004677	RNA-binding motif; other site
323098004678	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
323098004679	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
323098004680	dimer interface [polypeptide binding]; other site
323098004681	active site
323098004682	metal binding site [ion binding]; metal-binding site
323098004683	glutathione binding site [chemical binding]; other site
323098004684	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
323098004685	tape measure domain; Region: tape_meas_nterm; TIGR02675
323098004686	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
323098004687	Phage Terminase; Region: Terminase_1; pfam03354
323098004688	Phage terminase, small subunit; Region: Terminase_4; pfam05119
323098004689	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
323098004690	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
323098004691	Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883
323098004692	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
323098004693	oligomerization interface [polypeptide binding]; other site
323098004694	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
323098004695	Phage capsid family; Region: Phage_capsid; pfam05065
323098004696	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
323098004697	Phage-related protein [Function unknown]; Region: COG4695; cl01923
323098004698	Phage portal protein; Region: Phage_portal; pfam04860
323098004699	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
323098004700	polymerase nucleotide-binding site; other site
323098004701	DNA-binding residues [nucleotide binding]; DNA binding site
323098004702	nucleotide binding site [chemical binding]; other site
323098004703	primase nucleotide-binding site [nucleotide binding]; other site
323098004704	Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707
323098004705	AAA domain; Region: AAA_25; pfam13481
323098004706	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
323098004707	ATP binding site [chemical binding]; other site
323098004708	Walker B motif; other site
323098004709	Transcriptional regulators [Transcription]; Region: MarR; COG1846
323098004710	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
323098004711	integrase/recombinase; Provisional; Region: PRK15417
323098004712	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
323098004713	active site
323098004714	catalytic residues [active]
323098004715	DNA binding site [nucleotide binding]
323098004716	Int/Topo IB signature motif; other site
323098004717	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
323098004718	active site
323098004719	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
323098004720	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
323098004721	lysine-2,3-aminomutase-related protein; Region: AblA_like_2; TIGR03822
323098004722	FeS/SAM binding site; other site
323098004723	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
323098004724	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
323098004725	motif 1; other site
323098004726	dimer interface [polypeptide binding]; other site
323098004727	active site
323098004728	motif 2; other site
323098004729	motif 3; other site
323098004730	elongation factor P; Validated; Region: PRK00529
323098004731	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
323098004732	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
323098004733	RNA binding site [nucleotide binding]; other site
323098004734	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
323098004735	RNA binding site [nucleotide binding]; other site
323098004736	lytic murein transglycosylase; Region: MltB_2; TIGR02283
323098004737	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
323098004738	N-acetyl-D-glucosamine binding site [chemical binding]; other site
323098004739	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
323098004740	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
323098004741	DHH family; Region: DHH; pfam01368
323098004742	DHHA1 domain; Region: DHHA1; pfam02272
323098004743	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
323098004744	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
323098004745	putative active site [active]
323098004746	homoserine dehydrogenase; Provisional; Region: PRK06349
323098004747	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
323098004748	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
323098004749	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
323098004750	aminotransferase; Validated; Region: PRK09148
323098004751	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
323098004752	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323098004753	homodimer interface [polypeptide binding]; other site
323098004754	catalytic residue [active]
323098004755	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
323098004756	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
323098004757	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
323098004758	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
323098004759	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
323098004760	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
323098004761	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
323098004762	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
323098004763	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323098004764	Mg2+ binding site [ion binding]; other site
323098004765	G-X-G motif; other site
323098004766	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
323098004767	anchoring element; other site
323098004768	dimer interface [polypeptide binding]; other site
323098004769	ATP binding site [chemical binding]; other site
323098004770	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
323098004771	active site
323098004772	metal binding site [ion binding]; metal-binding site
323098004773	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
323098004774	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355
323098004775	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
323098004776	hypothetical protein; Provisional; Region: PRK06185
323098004777	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
323098004778	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
323098004779	Caspase domain; Region: Peptidase_C14; pfam00656
323098004780	active site
323098004781	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
323098004782	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
323098004783	ATP binding site [chemical binding]; other site
323098004784	Mg++ binding site [ion binding]; other site
323098004785	motif III; other site
323098004786	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
323098004787	nucleotide binding region [chemical binding]; other site
323098004788	ATP-binding site [chemical binding]; other site
323098004789	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
323098004790	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
323098004791	metal binding site [ion binding]; metal-binding site
323098004792	active site
323098004793	I-site; other site
323098004794	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
323098004795	Domain of unknown function DUF59; Region: DUF59; cl00941
323098004796	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
323098004797	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
323098004798	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
323098004799	catalytic residue [active]
323098004800	FeS assembly protein SufD; Region: sufD; TIGR01981
323098004801	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
323098004802	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
323098004803	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
323098004804	Walker A/P-loop; other site
323098004805	ATP binding site [chemical binding]; other site
323098004806	Q-loop/lid; other site
323098004807	ABC transporter signature motif; other site
323098004808	Walker B; other site
323098004809	D-loop; other site
323098004810	H-loop/switch region; other site
323098004811	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
323098004812	putative ABC transporter; Region: ycf24; CHL00085
323098004813	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
323098004814	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
323098004815	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
323098004816	catalytic residue [active]
323098004817	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
323098004818	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
323098004819	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
323098004820	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
323098004821	active site
323098004822	HIGH motif; other site
323098004823	dimer interface [polypeptide binding]; other site
323098004824	KMSKS motif; other site
323098004825	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
323098004826	RNA binding surface [nucleotide binding]; other site
323098004827	Protein of unknown function; Region: DUF3971; pfam13116
323098004828	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
323098004829	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
323098004830	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
323098004831	catalytic triad [active]
323098004832	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
323098004833	Peptidase family M23; Region: Peptidase_M23; pfam01551
323098004834	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
323098004835	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
323098004836	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
323098004837	ABC transporter; Region: ABC_tran_2; pfam12848
323098004838	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
323098004839	DNA polymerase III subunit chi; Validated; Region: PRK05728
323098004840	multifunctional aminopeptidase A; Provisional; Region: PRK00913
323098004841	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
323098004842	interface (dimer of trimers) [polypeptide binding]; other site
323098004843	Substrate-binding/catalytic site; other site
323098004844	Zn-binding sites [ion binding]; other site
323098004845	Predicted permeases [General function prediction only]; Region: COG0795
323098004846	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
323098004847	Predicted permeases [General function prediction only]; Region: COG0795
323098004848	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
323098004849	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
323098004850	Organic solvent tolerance protein; Region: OstA_C; pfam04453
323098004851	SurA N-terminal domain; Region: SurA_N; pfam09312
323098004852	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312
323098004853	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
323098004854	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323098004855	S-adenosylmethionine binding site [chemical binding]; other site
323098004856	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
323098004857	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
323098004858	catalytic site [active]
323098004859	G-X2-G-X-G-K; other site
323098004860	hypothetical protein; Provisional; Region: PRK11820
323098004861	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
323098004862	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
323098004863	YceG-like family; Region: YceG; pfam02618
323098004864	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
323098004865	dimerization interface [polypeptide binding]; other site
323098004866	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
323098004867	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
323098004868	dimer interface [polypeptide binding]; other site
323098004869	active site
323098004870	acyl carrier protein; Provisional; Region: acpP; PRK00982
323098004871	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323098004872	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
323098004873	NAD(P) binding site [chemical binding]; other site
323098004874	active site
323098004875	DNA polymerase II large subunit; Provisional; Region: PRK14714
323098004876	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
323098004877	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
323098004878	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
323098004879	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
323098004880	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
323098004881	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
323098004882	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
323098004883	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
323098004884	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323098004885	Walker A motif; other site
323098004886	ATP binding site [chemical binding]; other site
323098004887	Walker B motif; other site
323098004888	arginine finger; other site
323098004889	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323098004890	Walker A motif; other site
323098004891	ATP binding site [chemical binding]; other site
323098004892	Walker B motif; other site
323098004893	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
323098004894	Uncharacterized conserved protein [Function unknown]; Region: COG2127
323098004895	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
323098004896	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
323098004897	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
323098004898	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
323098004899	metal ion-dependent adhesion site (MIDAS); other site
323098004900	Phasin protein; Region: Phasin_2; pfam09361
323098004901	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
323098004902	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
323098004903	Sporulation related domain; Region: SPOR; pfam05036
323098004904	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
323098004905	HSP70 interaction site [polypeptide binding]; other site
323098004906	von Willebrand factor type A domain; Region: VWA_2; pfam13519
323098004907	Pantoate-beta-alanine ligase; Region: PanC; cd00560
323098004908	pantoate--beta-alanine ligase; Region: panC; TIGR00018
323098004909	active site
323098004910	ATP-binding site [chemical binding]; other site
323098004911	pantoate-binding site; other site
323098004912	HXXH motif; other site
323098004913	Protein of unknown function (DUF1489); Region: DUF1489; pfam07370
323098004914	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
323098004915	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
323098004916	putative C-terminal domain interface [polypeptide binding]; other site
323098004917	putative GSH binding site (G-site) [chemical binding]; other site
323098004918	putative dimer interface [polypeptide binding]; other site
323098004919	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
323098004920	putative N-terminal domain interface [polypeptide binding]; other site
323098004921	putative dimer interface [polypeptide binding]; other site
323098004922	putative substrate binding pocket (H-site) [chemical binding]; other site
323098004923	Protein of unknown function (DUF3253); Region: DUF3253; pfam11625
323098004924	Uncharacterized conserved protein [Function unknown]; Region: COG1434
323098004925	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
323098004926	putative active site [active]
323098004927	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
323098004928	non-specific DNA binding site [nucleotide binding]; other site
323098004929	salt bridge; other site
323098004930	sequence-specific DNA binding site [nucleotide binding]; other site
323098004931	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
323098004932	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
323098004933	NodB motif; other site
323098004934	active site
323098004935	catalytic site [active]
323098004936	metal binding site [ion binding]; metal-binding site
323098004937	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
323098004938	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
323098004939	active site
323098004940	interdomain interaction site; other site
323098004941	putative metal-binding site [ion binding]; other site
323098004942	nucleotide binding site [chemical binding]; other site
323098004943	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
323098004944	domain I; other site
323098004945	DNA binding groove [nucleotide binding]
323098004946	phosphate binding site [ion binding]; other site
323098004947	domain II; other site
323098004948	domain III; other site
323098004949	nucleotide binding site [chemical binding]; other site
323098004950	catalytic site [active]
323098004951	domain IV; other site
323098004952	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
323098004953	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
323098004954	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
323098004955	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
323098004956	ribonuclease R; Region: RNase_R; TIGR02063
323098004957	RNB domain; Region: RNB; pfam00773
323098004958	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
323098004959	RNA binding site [nucleotide binding]; other site
323098004960	hypothetical protein; Provisional; Region: PRK05978
323098004961	peptide chain release factor 2; Provisional; Region: PRK07342
323098004962	This domain is found in peptide chain release factors; Region: PCRF; smart00937
323098004963	RF-1 domain; Region: RF-1; pfam00472
323098004964	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
323098004965	Transglycosylase; Region: Transgly; pfam00912
323098004966	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
323098004967	Winged helix-turn helix; Region: HTH_29; pfam13551
323098004968	Integrase core domain; Region: rve; pfam00665
323098004969	Integrase core domain; Region: rve_3; pfam13683
323098004970	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323098004971	AMIN domain; Region: AMIN; pfam11741
323098004972	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
323098004973	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
323098004974	active site
323098004975	metal binding site [ion binding]; metal-binding site
323098004976	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
323098004977	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
323098004978	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
323098004979	thiamine monophosphate kinase; Provisional; Region: PRK05731
323098004980	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
323098004981	ATP binding site [chemical binding]; other site
323098004982	dimerization interface [polypeptide binding]; other site
323098004983	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
323098004984	putative RNA binding site [nucleotide binding]; other site
323098004985	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
323098004986	homopentamer interface [polypeptide binding]; other site
323098004987	active site
323098004988	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
323098004989	Lumazine binding domain; Region: Lum_binding; pfam00677
323098004990	Lumazine binding domain; Region: Lum_binding; pfam00677
323098004991	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
323098004992	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
323098004993	catalytic motif [active]
323098004994	Zn binding site [ion binding]; other site
323098004995	RibD C-terminal domain; Region: RibD_C; cl17279
323098004996	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
323098004997	ATP cone domain; Region: ATP-cone; pfam03477
323098004998	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
323098004999	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
323098005000	dimer interface [polypeptide binding]; other site
323098005001	active site
323098005002	glycine-pyridoxal phosphate binding site [chemical binding]; other site
323098005003	folate binding site [chemical binding]; other site
323098005004	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
323098005005	hypothetical protein; Validated; Region: PRK06033
323098005006	lipoate-protein ligase B; Provisional; Region: PRK14341
323098005007	Secretin and TonB N terminus short domain; Region: STN; smart00965
323098005008	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
323098005009	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
323098005010	N-terminal plug; other site
323098005011	ligand-binding site [chemical binding]; other site
323098005012	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
323098005013	FecR protein; Region: FecR; pfam04773
323098005014	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
323098005015	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
323098005016	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
323098005017	DNA binding residues [nucleotide binding]
323098005018	acylphosphatase; Provisional; Region: PRK14421
323098005019	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
323098005020	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
323098005021	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
323098005022	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
323098005023	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
323098005024	carboxyltransferase (CT) interaction site; other site
323098005025	biotinylation site [posttranslational modification]; other site
323098005026	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
323098005027	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
323098005028	dimer interface [polypeptide binding]; other site
323098005029	decamer (pentamer of dimers) interface [polypeptide binding]; other site
323098005030	catalytic triad [active]
323098005031	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
323098005032	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
323098005033	substrate binding site [chemical binding]; other site
323098005034	catalytic Zn binding site [ion binding]; other site
323098005035	NAD binding site [chemical binding]; other site
323098005036	structural Zn binding site [ion binding]; other site
323098005037	dimer interface [polypeptide binding]; other site
323098005038	CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080
323098005039	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
323098005040	cyclase homology domain; Region: CHD; cd07302
323098005041	nucleotidyl binding site; other site
323098005042	metal binding site [ion binding]; metal-binding site
323098005043	dimer interface [polypeptide binding]; other site
323098005044	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
323098005045	binding surface
323098005046	Tetratricopeptide repeat; Region: TPR_16; pfam13432
323098005047	TPR motif; other site
323098005048	HAMP domain; Region: HAMP; pfam00672
323098005049	nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938
323098005050	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323098005051	putative active site [active]
323098005052	heme pocket [chemical binding]; other site
323098005053	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323098005054	putative active site [active]
323098005055	heme pocket [chemical binding]; other site
323098005056	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323098005057	ATP binding site [chemical binding]; other site
323098005058	Mg2+ binding site [ion binding]; other site
323098005059	G-X-G motif; other site
323098005060	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
323098005061	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
323098005062	dimer interface [polypeptide binding]; other site
323098005063	PYR/PP interface [polypeptide binding]; other site
323098005064	TPP binding site [chemical binding]; other site
323098005065	substrate binding site [chemical binding]; other site
323098005066	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
323098005067	TPP-binding site [chemical binding]; other site
323098005068	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
323098005069	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
323098005070	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
323098005071	aspartate aminotransferase; Provisional; Region: PRK05764
323098005072	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
323098005073	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323098005074	homodimer interface [polypeptide binding]; other site
323098005075	catalytic residue [active]
323098005076	Peptidase family M48; Region: Peptidase_M48; cl12018
323098005077	Tetratricopeptide repeat; Region: TPR_16; pfam13432
323098005078	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
323098005079	TPR motif; other site
323098005080	binding surface
323098005081	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
323098005082	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
323098005083	catalytic residues [active]
323098005084	Dehydroquinase class II; Region: DHquinase_II; pfam01220
323098005085	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
323098005086	trimer interface [polypeptide binding]; other site
323098005087	active site
323098005088	dimer interface [polypeptide binding]; other site
323098005089	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
323098005090	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
323098005091	carboxyltransferase (CT) interaction site; other site
323098005092	biotinylation site [posttranslational modification]; other site
323098005093	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
323098005094	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
323098005095	ATP-grasp domain; Region: ATP-grasp_4; cl17255
323098005096	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
323098005097	CHASE3 domain; Region: CHASE3; pfam05227
323098005098	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
323098005099	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323098005100	ATP binding site [chemical binding]; other site
323098005101	Mg2+ binding site [ion binding]; other site
323098005102	G-X-G motif; other site
323098005103	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
323098005104	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323098005105	active site
323098005106	phosphorylation site [posttranslational modification]
323098005107	intermolecular recognition site; other site
323098005108	dimerization interface [polypeptide binding]; other site
323098005109	Response regulator receiver domain; Region: Response_reg; pfam00072
323098005110	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323098005111	active site
323098005112	phosphorylation site [posttranslational modification]
323098005113	intermolecular recognition site; other site
323098005114	dimerization interface [polypeptide binding]; other site
323098005115	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
323098005116	Histidine kinase; Region: HisKA_2; pfam07568
323098005117	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323098005118	ATP binding site [chemical binding]; other site
323098005119	Mg2+ binding site [ion binding]; other site
323098005120	G-X-G motif; other site
323098005121	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
323098005122	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765
323098005123	FecR protein; Region: FecR; pfam04773
323098005124	NADH dehydrogenase; Validated; Region: PRK08183
323098005125	Predicted acetyltransferase [General function prediction only]; Region: COG2388
323098005126	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
323098005127	Predicted integral membrane protein [Function unknown]; Region: COG5473
323098005128	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
323098005129	Glucose inhibited division protein A; Region: GIDA; pfam01134
323098005130	serine/threonine protein kinase; Provisional; Region: PRK09188
323098005131	serine/threonine protein kinase; Provisional; Region: PRK12274
323098005132	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
323098005133	Squalene/phytoene synthase; Region: SQS_PSY; pfam00494
323098005134	substrate binding pocket [chemical binding]; other site
323098005135	aspartate-rich region 2; other site
323098005136	substrate-Mg2+ binding site; other site
323098005137	Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248
323098005138	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
323098005139	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
323098005140	Protein export membrane protein; Region: SecD_SecF; pfam02355
323098005141	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
323098005142	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
323098005143	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
323098005144	Preprotein translocase subunit; Region: YajC; pfam02699
323098005145	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
323098005146	Protein of unknown function (DUF815); Region: DUF815; pfam05673
323098005147	Walker A motif; other site
323098005148	ATP binding site [chemical binding]; other site
323098005149	Walker B motif; other site
323098005150	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
323098005151	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
323098005152	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
323098005153	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
323098005154	Peptidase family M23; Region: Peptidase_M23; pfam01551
323098005155	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
323098005156	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323098005157	S-adenosylmethionine binding site [chemical binding]; other site
323098005158	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
323098005159	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323098005160	active site
323098005161	phosphorylation site [posttranslational modification]
323098005162	intermolecular recognition site; other site
323098005163	dimerization interface [polypeptide binding]; other site
323098005164	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
323098005165	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
323098005166	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
323098005167	motif 1; other site
323098005168	seryl-tRNA synthetase; Provisional; Region: PRK05431
323098005169	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
323098005170	active site
323098005171	dimer interface [polypeptide binding]; other site
323098005172	motif 2; other site
323098005173	motif 3; other site
323098005174	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
323098005175	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
323098005176	twin arginine translocase protein A; Provisional; Region: tatA; PRK00720
323098005177	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
323098005178	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323098005179	S-adenosylmethionine binding site [chemical binding]; other site
323098005180	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
323098005181	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
323098005182	Substrate binding site; other site
323098005183	Mg++ binding site; other site
323098005184	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
323098005185	active site
323098005186	substrate binding site [chemical binding]; other site
323098005187	CoA binding site [chemical binding]; other site
323098005188	Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309
323098005189	Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309
323098005190	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
323098005191	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
323098005192	active site
323098005193	Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588
323098005194	PcfJ-like protein; Region: PcfJ; pfam14284
323098005195	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
323098005196	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
323098005197	dimer interface [polypeptide binding]; other site
323098005198	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323098005199	catalytic residue [active]
323098005200	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
323098005201	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
323098005202	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
323098005203	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
323098005204	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
323098005205	active site
323098005206	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
323098005207	active site
323098005208	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
323098005209	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
323098005210	active site
323098005211	(T/H)XGH motif; other site
323098005212	DNA gyrase, A subunit; Region: gyrA; TIGR01063
323098005213	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
323098005214	CAP-like domain; other site
323098005215	active site
323098005216	primary dimer interface [polypeptide binding]; other site
323098005217	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
323098005218	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
323098005219	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
323098005220	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
323098005221	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
323098005222	MarC family integral membrane protein; Region: MarC; cl00919
323098005223	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
323098005224	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
323098005225	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
323098005226	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
323098005227	Sporulation related domain; Region: SPOR; pfam05036
323098005228	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
323098005229	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
323098005230	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
323098005231	active site
323098005232	HIGH motif; other site
323098005233	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
323098005234	KMSK motif region; other site
323098005235	tRNA binding surface [nucleotide binding]; other site
323098005236	DALR anticodon binding domain; Region: DALR_1; smart00836
323098005237	anticodon binding site; other site
323098005238	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
323098005239	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
323098005240	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
323098005241	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
323098005242	putative catalytic site [active]
323098005243	putative phosphate binding site [ion binding]; other site
323098005244	active site
323098005245	metal binding site A [ion binding]; metal-binding site
323098005246	DNA binding site [nucleotide binding]
323098005247	putative AP binding site [nucleotide binding]; other site
323098005248	putative metal binding site B [ion binding]; other site
323098005249	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
323098005250	Sel1-like repeats; Region: SEL1; smart00671
323098005251	Sel1 repeat; Region: Sel1; cl02723
323098005252	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
323098005253	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
323098005254	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
323098005255	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
323098005256	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
323098005257	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
323098005258	ligand binding site [chemical binding]; other site
323098005259	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
323098005260	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349
323098005261	E3 interaction surface; other site
323098005262	lipoyl attachment site [posttranslational modification]; other site
323098005263	e3 binding domain; Region: E3_binding; pfam02817
323098005264	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
323098005265	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
323098005266	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
323098005267	E3 interaction surface; other site
323098005268	lipoyl attachment site [posttranslational modification]; other site
323098005269	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
323098005270	alpha subunit interface [polypeptide binding]; other site
323098005271	TPP binding site [chemical binding]; other site
323098005272	heterodimer interface [polypeptide binding]; other site
323098005273	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
323098005274	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
323098005275	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
323098005276	tetramer interface [polypeptide binding]; other site
323098005277	TPP-binding site [chemical binding]; other site
323098005278	heterodimer interface [polypeptide binding]; other site
323098005279	phosphorylation loop region [posttranslational modification]
323098005280	Septum formation initiator; Region: DivIC; pfam04977
323098005281	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
323098005282	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
323098005283	Predicted flavoprotein [General function prediction only]; Region: COG0431
323098005284	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
323098005285	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
323098005286	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
323098005287	Autotransporter beta-domain; Region: Autotransporter; smart00869
323098005288	enolase; Provisional; Region: eno; PRK00077
323098005289	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
323098005290	dimer interface [polypeptide binding]; other site
323098005291	metal binding site [ion binding]; metal-binding site
323098005292	substrate binding pocket [chemical binding]; other site
323098005293	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
323098005294	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323098005295	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
323098005296	putative substrate translocation pore; other site
323098005297	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
323098005298	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
323098005299	PAAR motif; Region: PAAR_motif; pfam05488
323098005300	CTP synthetase; Validated; Region: pyrG; PRK05380
323098005301	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
323098005302	Catalytic site [active]
323098005303	active site
323098005304	UTP binding site [chemical binding]; other site
323098005305	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
323098005306	active site
323098005307	putative oxyanion hole; other site
323098005308	catalytic triad [active]
323098005309	protein translocase, SecG subunit; Region: secG; TIGR00810
323098005310	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
323098005311	triosephosphate isomerase; Provisional; Region: PRK14565
323098005312	substrate binding site [chemical binding]; other site
323098005313	dimer interface [polypeptide binding]; other site
323098005314	catalytic triad [active]
323098005315	SurA N-terminal domain; Region: SurA_N_3; cl07813
323098005316	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
323098005317	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
323098005318	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
323098005319	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
323098005320	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
323098005321	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
323098005322	active site
323098005323	ribulose/triose binding site [chemical binding]; other site
323098005324	phosphate binding site [ion binding]; other site
323098005325	substrate (anthranilate) binding pocket [chemical binding]; other site
323098005326	product (indole) binding pocket [chemical binding]; other site
323098005327	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
323098005328	trimer interface [polypeptide binding]; other site
323098005329	dimer interface [polypeptide binding]; other site
323098005330	putative active site [active]
323098005331	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
323098005332	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
323098005333	dimer interface [polypeptide binding]; other site
323098005334	putative functional site; other site
323098005335	putative MPT binding site; other site
323098005336	LexA repressor; Validated; Region: PRK00215
323098005337	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
323098005338	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
323098005339	Catalytic site [active]
323098005340	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
323098005341	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
323098005342	Competence protein; Region: Competence; pfam03772
323098005343	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
323098005344	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
323098005345	active site
323098005346	HIGH motif; other site
323098005347	nucleotide binding site [chemical binding]; other site
323098005348	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
323098005349	KMSKS motif; other site
323098005350	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
323098005351	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
323098005352	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
323098005353	HIGH motif; other site
323098005354	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
323098005355	active site
323098005356	KMSKS motif; other site
323098005357	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
323098005358	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
323098005359	dimer interface [polypeptide binding]; other site
323098005360	active site
323098005361	citrylCoA binding site [chemical binding]; other site
323098005362	NADH binding [chemical binding]; other site
323098005363	cationic pore residues; other site
323098005364	oxalacetate/citrate binding site [chemical binding]; other site
323098005365	coenzyme A binding site [chemical binding]; other site
323098005366	catalytic triad [active]
323098005367	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
323098005368	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
323098005369	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
323098005370	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
323098005371	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
323098005372	active site
323098005373	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
323098005374	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
323098005375	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
323098005376	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
323098005377	trimer interface [polypeptide binding]; other site
323098005378	active site
323098005379	UDP-GlcNAc binding site [chemical binding]; other site
323098005380	lipid binding site [chemical binding]; lipid-binding site
323098005381	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
323098005382	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
323098005383	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
323098005384	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
323098005385	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
323098005386	Surface antigen; Region: Bac_surface_Ag; pfam01103
323098005387	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
323098005388	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
323098005389	active site
323098005390	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
323098005391	protein binding site [polypeptide binding]; other site
323098005392	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
323098005393	putative substrate binding region [chemical binding]; other site
323098005394	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
323098005395	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
323098005396	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
323098005397	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
323098005398	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
323098005399	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
323098005400	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834
323098005401	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
323098005402	catalytic residue [active]
323098005403	putative FPP diphosphate  binding site; other site
323098005404	putative FPP binding hydrophobic cleft; other site
323098005405	dimer interface [polypeptide binding]; other site
323098005406	putative IPP diphosphate binding site; other site
323098005407	ribosome recycling factor; Reviewed; Region: frr; PRK00083
323098005408	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
323098005409	hinge region; other site
323098005410	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
323098005411	putative nucleotide binding site [chemical binding]; other site
323098005412	uridine monophosphate binding site [chemical binding]; other site
323098005413	homohexameric interface [polypeptide binding]; other site
323098005414	elongation factor Ts; Provisional; Region: tsf; PRK09377
323098005415	UBA/TS-N domain; Region: UBA; pfam00627
323098005416	Elongation factor TS; Region: EF_TS; pfam00889
323098005417	Elongation factor TS; Region: EF_TS; pfam00889
323098005418	30S ribosomal protein S2/unknown domain fusion protein; Provisional; Region: rpsB; PRK12311
323098005419	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
323098005420	rRNA interaction site [nucleotide binding]; other site
323098005421	S8 interaction site; other site
323098005422	putative laminin-1 binding site; other site
323098005423	Uncharacterized conserved protein [Function unknown]; Region: COG3743
323098005424	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
323098005425	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
323098005426	putative active site [active]
323098005427	putative PHP Thumb interface [polypeptide binding]; other site
323098005428	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
323098005429	generic binding surface I; other site
323098005430	generic binding surface II; other site
323098005431	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
323098005432	active site
323098005433	dimer interface [polypeptide binding]; other site
323098005434	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
323098005435	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
323098005436	Walker A/P-loop; other site
323098005437	ATP binding site [chemical binding]; other site
323098005438	Q-loop/lid; other site
323098005439	ABC transporter signature motif; other site
323098005440	Walker B; other site
323098005441	D-loop; other site
323098005442	H-loop/switch region; other site
323098005443	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
323098005444	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
323098005445	FtsX-like permease family; Region: FtsX; pfam02687
323098005446	prolyl-tRNA synthetase; Provisional; Region: PRK12325
323098005447	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
323098005448	dimer interface [polypeptide binding]; other site
323098005449	motif 1; other site
323098005450	active site
323098005451	motif 2; other site
323098005452	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
323098005453	active site
323098005454	motif 3; other site
323098005455	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
323098005456	anticodon binding site; other site
323098005457	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
323098005458	Protein of unknown function (DUF461); Region: DUF461; pfam04314
323098005459	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
323098005460	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
323098005461	N-terminal plug; other site
323098005462	ligand-binding site [chemical binding]; other site
323098005463	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
323098005464	Protein of unknown function (DUF1467); Region: DUF1467; pfam07330
323098005465	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
323098005466	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
323098005467	dimer interface [polypeptide binding]; other site
323098005468	substrate binding site [chemical binding]; other site
323098005469	metal binding site [ion binding]; metal-binding site
323098005470	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
323098005471	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
323098005472	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
323098005473	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
323098005474	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
323098005475	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
323098005476	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
323098005477	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
323098005478	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
323098005479	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
323098005480	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
323098005481	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
323098005482	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
323098005483	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
323098005484	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
323098005485	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
323098005486	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
323098005487	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
323098005488	4Fe-4S binding domain; Region: Fer4; pfam00037
323098005489	4Fe-4S binding domain; Region: Fer4; pfam00037
323098005490	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
323098005491	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
323098005492	NADH dehydrogenase subunit G; Validated; Region: PRK09130
323098005493	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
323098005494	catalytic loop [active]
323098005495	iron binding site [ion binding]; other site
323098005496	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
323098005497	MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773
323098005498	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
323098005499	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
323098005500	SLBB domain; Region: SLBB; pfam10531
323098005501	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
323098005502	NADH dehydrogenase subunit E; Validated; Region: PRK07539
323098005503	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
323098005504	putative dimer interface [polypeptide binding]; other site
323098005505	[2Fe-2S] cluster binding site [ion binding]; other site
323098005506	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
323098005507	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
323098005508	NADH dehydrogenase subunit D; Validated; Region: PRK06075
323098005509	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
323098005510	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
323098005511	NADH dehydrogenase subunit B; Validated; Region: PRK06411
323098005512	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
323098005513	Protein of unknown function (DUF2798); Region: DUF2798; pfam11391
323098005514	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
323098005515	IHF - DNA interface [nucleotide binding]; other site
323098005516	IHF dimer interface [polypeptide binding]; other site
323098005517	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
323098005518	peptidase T; Region: peptidase-T; TIGR01882
323098005519	metal binding site [ion binding]; metal-binding site
323098005520	dimer interface [polypeptide binding]; other site
323098005521	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323098005522	S-adenosylmethionine binding site [chemical binding]; other site
323098005523	Methyltransferase domain; Region: Methyltransf_31; pfam13847
323098005524	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323098005525	S-adenosylmethionine binding site [chemical binding]; other site
323098005526	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
323098005527	Found in ATP-dependent protease La (LON); Region: LON; smart00464
323098005528	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
323098005529	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323098005530	Walker A motif; other site
323098005531	ATP binding site [chemical binding]; other site
323098005532	Walker B motif; other site
323098005533	arginine finger; other site
323098005534	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
323098005535	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
323098005536	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
323098005537	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323098005538	Walker A motif; other site
323098005539	ATP binding site [chemical binding]; other site
323098005540	Walker B motif; other site
323098005541	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
323098005542	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
323098005543	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
323098005544	oligomer interface [polypeptide binding]; other site
323098005545	active site residues [active]
323098005546	trigger factor; Provisional; Region: tig; PRK01490
323098005547	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
323098005548	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
323098005549	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
323098005550	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
323098005551	Multicopper oxidase; Region: Cu-oxidase; pfam00394
323098005552	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
323098005553	Uncharacterized conserved protein [Function unknown]; Region: COG0062
323098005554	putative carbohydrate kinase; Provisional; Region: PRK10565
323098005555	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
323098005556	putative substrate binding site [chemical binding]; other site
323098005557	putative ATP binding site [chemical binding]; other site
323098005558	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
323098005559	Nitrogen regulatory protein P-II; Region: P-II; smart00938
323098005560	glutamine synthetase; Provisional; Region: glnA; PRK09469
323098005561	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
323098005562	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
323098005563	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
323098005564	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
323098005565	Transcriptional regulators [Transcription]; Region: MarR; COG1846
323098005566	MarR family; Region: MarR_2; cl17246
323098005567	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
323098005568	dimer interface [polypeptide binding]; other site
323098005569	allosteric magnesium binding site [ion binding]; other site
323098005570	active site
323098005571	aspartate-rich active site metal binding site; other site
323098005572	Schiff base residues; other site
323098005573	RDD family; Region: RDD; pfam06271
323098005574	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
323098005575	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
323098005576	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
323098005577	manganese transport protein MntH; Reviewed; Region: PRK00701
323098005578	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
323098005579	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
323098005580	ArsC family; Region: ArsC; pfam03960
323098005581	catalytic residues [active]
323098005582	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
323098005583	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
323098005584	CAP-like domain; other site
323098005585	active site
323098005586	primary dimer interface [polypeptide binding]; other site
323098005587	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
323098005588	Recombination protein O N terminal; Region: RecO_N; pfam11967
323098005589	Recombination protein O C terminal; Region: RecO_C; pfam02565
323098005590	GTPase Era; Reviewed; Region: era; PRK00089
323098005591	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
323098005592	G1 box; other site
323098005593	GTP/Mg2+ binding site [chemical binding]; other site
323098005594	Switch I region; other site
323098005595	G2 box; other site
323098005596	Switch II region; other site
323098005597	G3 box; other site
323098005598	G4 box; other site
323098005599	G5 box; other site
323098005600	KH domain; Region: KH_2; pfam07650
323098005601	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
323098005602	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
323098005603	dimerization interface [polypeptide binding]; other site
323098005604	active site
323098005605	metal binding site [ion binding]; metal-binding site
323098005606	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
323098005607	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
323098005608	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
323098005609	Catalytic site [active]
323098005610	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
323098005611	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
323098005612	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
323098005613	active site
323098005614	hydrophilic channel; other site
323098005615	dimerization interface [polypeptide binding]; other site
323098005616	catalytic residues [active]
323098005617	active site lid [active]
323098005618	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
323098005619	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
323098005620	Zn2+ binding site [ion binding]; other site
323098005621	Mg2+ binding site [ion binding]; other site
323098005622	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
323098005623	synthetase active site [active]
323098005624	NTP binding site [chemical binding]; other site
323098005625	metal binding site [ion binding]; metal-binding site
323098005626	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
323098005627	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
323098005628	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
323098005629	Uncharacterized conserved protein [Function unknown]; Region: COG1432
323098005630	LabA_like proteins; Region: LabA; cd10911
323098005631	putative metal binding site [ion binding]; other site
323098005632	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
323098005633	Fe-S cluster binding site [ion binding]; other site
323098005634	DNA binding site [nucleotide binding]
323098005635	active site
323098005636	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
323098005637	SmpB-tmRNA interface; other site
323098005638	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
323098005639	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
323098005640	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
323098005641	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
323098005642	dimer interface [polypeptide binding]; other site
323098005643	active site
323098005644	catalytic residue [active]
323098005645	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
323098005646	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
323098005647	N-acetyl-D-glucosamine binding site [chemical binding]; other site
323098005648	catalytic residue [active]
323098005649	Transposase; Region: HTH_Tnp_1; pfam01527
323098005650	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323098005651	Helix-turn-helix domain; Region: HTH_28; pfam13518
323098005652	Winged helix-turn helix; Region: HTH_29; pfam13551
323098005653	Homeodomain-like domain; Region: HTH_32; pfam13565
323098005654	Integrase core domain; Region: rve; pfam00665
323098005655	Integrase core domain; Region: rve_3; pfam13683
323098005656	Porin subfamily; Region: Porin_2; pfam02530
323098005657	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323098005658	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
323098005659	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
323098005660	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721
323098005661	CRISPR-associated protein Cas4; Region: cas4; TIGR00372
323098005662	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09689
323098005663	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757
323098005664	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
323098005665	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752
323098005666	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
323098005667	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
323098005668	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
323098005669	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
323098005670	catalytic residues [active]
323098005671	catalytic nucleophile [active]
323098005672	Presynaptic Site I dimer interface [polypeptide binding]; other site
323098005673	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
323098005674	Synaptic Flat tetramer interface [polypeptide binding]; other site
323098005675	Synaptic Site I dimer interface [polypeptide binding]; other site
323098005676	DNA binding site [nucleotide binding]
323098005677	Recombinase; Region: Recombinase; pfam07508
323098005678	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
323098005679	Transposase; Region: HTH_Tnp_1; pfam01527
323098005680	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323098005681	Helix-turn-helix domain; Region: HTH_28; pfam13518
323098005682	Winged helix-turn helix; Region: HTH_29; pfam13551
323098005683	Homeodomain-like domain; Region: HTH_32; pfam13565
323098005684	Integrase core domain; Region: rve; pfam00665
323098005685	Integrase core domain; Region: rve_3; pfam13683
323098005686	putative phosphoketolase; Provisional; Region: PRK05261
323098005687	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
323098005688	TPP-binding site; other site
323098005689	XFP C-terminal domain; Region: XFP_C; pfam09363
323098005690	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
323098005691	propionate/acetate kinase; Provisional; Region: PRK12379
323098005692	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
323098005693	Propanediol utilisation protein PduL; Region: PduL; pfam06130
323098005694	Propanediol utilisation protein PduL; Region: PduL; pfam06130
323098005695	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
323098005696	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
323098005697	Soluble P-type ATPase [General function prediction only]; Region: COG4087
323098005698	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
323098005699	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
323098005700	catalytic residues [active]
323098005701	catalytic nucleophile [active]
323098005702	Presynaptic Site I dimer interface [polypeptide binding]; other site
323098005703	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
323098005704	Synaptic Flat tetramer interface [polypeptide binding]; other site
323098005705	Synaptic Site I dimer interface [polypeptide binding]; other site
323098005706	DNA binding site [nucleotide binding]
323098005707	Recombinase; Region: Recombinase; pfam07508
323098005708	Protein of unknown function (DUF2924); Region: DUF2924; pfam11149
323098005709	Domain of unknown function DUF87; Region: DUF87; pfam01935
323098005710	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
323098005711	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
323098005712	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
323098005713	non-specific DNA binding site [nucleotide binding]; other site
323098005714	salt bridge; other site
323098005715	sequence-specific DNA binding site [nucleotide binding]; other site
323098005716	Domain of unknown function (DUF955); Region: DUF955; cl01076
323098005717	Helix-turn-helix domain; Region: HTH_17; pfam12728
323098005718	AAA domain; Region: AAA_24; pfam13479
323098005719	Helix-turn-helix domain; Region: HTH_28; pfam13518
323098005720	Winged helix-turn helix; Region: HTH_29; pfam13551
323098005721	Homeodomain-like domain; Region: HTH_32; pfam13565
323098005722	Integrase core domain; Region: rve; pfam00665
323098005723	Integrase core domain; Region: rve_3; pfam13683
323098005724	Transposase; Region: HTH_Tnp_1; pfam01527
323098005725	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323098005726	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
323098005727	DNA binding residues [nucleotide binding]
323098005728	Winged helix-turn helix; Region: HTH_29; pfam13551
323098005729	Homeodomain-like domain; Region: HTH_23; cl17451
323098005730	Homeodomain-like domain; Region: HTH_32; pfam13565
323098005731	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323098005732	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323098005733	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
323098005734	FecR protein; Region: FecR; pfam04773
323098005735	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
323098005736	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051
323098005737	putative hexamer interface [polypeptide binding]; other site
323098005738	putative hexagonal pore; other site
323098005739	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052
323098005740	putative hexamer interface [polypeptide binding]; other site
323098005741	putative hexagonal pore; other site
323098005742	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
323098005743	MoxR-like ATPases [General function prediction only]; Region: COG0714
323098005744	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
323098005745	Walker A motif; other site
323098005746	ATP binding site [chemical binding]; other site
323098005747	Walker B motif; other site
323098005748	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
323098005749	ParA-like protein; Provisional; Region: PHA02518
323098005750	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
323098005751	P-loop; other site
323098005752	Magnesium ion binding site [ion binding]; other site
323098005753	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942
323098005754	aromatic arch; other site
323098005755	DCoH dimer interaction site [polypeptide binding]; other site
323098005756	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
323098005757	DCoH tetramer interaction site [polypeptide binding]; other site
323098005758	substrate binding site [chemical binding]; other site
323098005759	Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058
323098005760	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
323098005761	Hexamer interface [polypeptide binding]; other site
323098005762	Hexagonal pore residue; other site
323098005763	Hexagonal pore; other site
323098005764	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
323098005765	Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058
323098005766	Hexamer interface [polypeptide binding]; other site
323098005767	Hexagonal pore residue; other site
323098005768	Hexagonal pore; other site
323098005769	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
323098005770	Hexamer/Pentamer interface [polypeptide binding]; other site
323098005771	central pore; other site
323098005772	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
323098005773	Hexamer/Pentamer interface [polypeptide binding]; other site
323098005774	central pore; other site
323098005775	Carboxysome Shell Carbonic Anhydrase; Region: CsoSCA; pfam08936
323098005776	Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288
323098005777	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
323098005778	multimerization interface [polypeptide binding]; other site
323098005779	ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208
323098005780	Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232
323098005781	dimer interface [polypeptide binding]; other site
323098005782	catalytic residue [active]
323098005783	metal binding site [ion binding]; metal-binding site
323098005784	Transcriptional regulator [Transcription]; Region: LysR; COG0583
323098005785	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
323098005786	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
323098005787	putative dimerization interface [polypeptide binding]; other site
323098005788	Nitrogen regulatory protein P-II; Region: P-II; cl00412
323098005789	Nitrogen regulatory protein P-II; Region: P-II; smart00938
323098005790	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
323098005791	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
323098005792	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
323098005793	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
323098005794	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
323098005795	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
323098005796	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
323098005797	GatB domain; Region: GatB_Yqey; smart00845
323098005798	Patatin-like phospholipase; Region: Patatin; pfam01734
323098005799	active site
323098005800	nucleophile elbow; other site
323098005801	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323098005802	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323098005803	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
323098005804	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
323098005805	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
323098005806	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
323098005807	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
323098005808	CAAX protease self-immunity; Region: Abi; pfam02517
323098005809	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
323098005810	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
323098005811	active site
323098005812	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
323098005813	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
323098005814	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
323098005815	dihydroorotase; Validated; Region: PRK09059
323098005816	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
323098005817	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
323098005818	active site
323098005819	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
323098005820	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
323098005821	DNA protecting protein DprA; Region: dprA; TIGR00732
323098005822	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
323098005823	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323098005824	S-adenosylmethionine binding site [chemical binding]; other site
323098005825	replicative DNA helicase; Provisional; Region: PRK09165
323098005826	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
323098005827	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
323098005828	Walker A motif; other site
323098005829	ATP binding site [chemical binding]; other site
323098005830	Walker B motif; other site
323098005831	DNA binding loops [nucleotide binding]
323098005832	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
323098005833	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
323098005834	active site
323098005835	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
323098005836	dimer interface [polypeptide binding]; other site
323098005837	substrate binding site [chemical binding]; other site
323098005838	catalytic residues [active]
323098005839	DNA repair protein RadA; Provisional; Region: PRK11823
323098005840	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
323098005841	Walker A motif; other site
323098005842	ATP binding site [chemical binding]; other site
323098005843	Walker B motif; other site
323098005844	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
323098005845	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
323098005846	Colicin V production protein; Region: Colicin_V; pfam02674
323098005847	amidophosphoribosyltransferase; Provisional; Region: PRK09123
323098005848	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
323098005849	active site
323098005850	tetramer interface [polypeptide binding]; other site
323098005851	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
323098005852	active site
323098005853	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
323098005854	short chain dehydrogenase; Provisional; Region: PRK12829
323098005855	classical (c) SDRs; Region: SDR_c; cd05233
323098005856	NAD(P) binding site [chemical binding]; other site
323098005857	active site
323098005858	GTP-binding protein Der; Reviewed; Region: PRK00093
323098005859	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
323098005860	G1 box; other site
323098005861	GTP/Mg2+ binding site [chemical binding]; other site
323098005862	Switch I region; other site
323098005863	G2 box; other site
323098005864	Switch II region; other site
323098005865	G3 box; other site
323098005866	G4 box; other site
323098005867	G5 box; other site
323098005868	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
323098005869	G1 box; other site
323098005870	GTP/Mg2+ binding site [chemical binding]; other site
323098005871	Switch I region; other site
323098005872	G2 box; other site
323098005873	G3 box; other site
323098005874	Switch II region; other site
323098005875	G4 box; other site
323098005876	G5 box; other site
323098005877	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
323098005878	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
323098005879	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
323098005880	oligomerization interface [polypeptide binding]; other site
323098005881	active site
323098005882	metal binding site [ion binding]; metal-binding site
323098005883	NnrU protein; Region: NnrU; pfam07298
323098005884	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
323098005885	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
323098005886	G1 box; other site
323098005887	putative GEF interaction site [polypeptide binding]; other site
323098005888	GTP/Mg2+ binding site [chemical binding]; other site
323098005889	Switch I region; other site
323098005890	G2 box; other site
323098005891	G3 box; other site
323098005892	Switch II region; other site
323098005893	G4 box; other site
323098005894	G5 box; other site
323098005895	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
323098005896	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
323098005897	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323098005898	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323098005899	Winged helix-turn helix; Region: HTH_29; pfam13551
323098005900	Homeodomain-like domain; Region: HTH_23; cl17451
323098005901	Homeodomain-like domain; Region: HTH_32; pfam13565
323098005902	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
323098005903	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
323098005904	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
323098005905	ArsC family; Region: ArsC; pfam03960
323098005906	putative catalytic residues [active]
323098005907	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
323098005908	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
323098005909	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
323098005910	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
323098005911	active site
323098005912	dimer interface [polypeptide binding]; other site
323098005913	motif 1; other site
323098005914	motif 2; other site
323098005915	motif 3; other site
323098005916	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
323098005917	anticodon binding site; other site
323098005918	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
323098005919	putative FMN binding site [chemical binding]; other site
323098005920	TonB C terminal; Region: TonB_2; pfam13103
323098005921	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
323098005922	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
323098005923	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
323098005924	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
323098005925	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
323098005926	Walker A/P-loop; other site
323098005927	ATP binding site [chemical binding]; other site
323098005928	Q-loop/lid; other site
323098005929	ABC transporter signature motif; other site
323098005930	Walker B; other site
323098005931	D-loop; other site
323098005932	H-loop/switch region; other site
323098005933	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
323098005934	FtsX-like permease family; Region: FtsX; pfam02687
323098005935	macrolide transporter subunit MacA; Provisional; Region: PRK11578
323098005936	HlyD family secretion protein; Region: HlyD_3; pfam13437
323098005937	C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD); Region: AP_MHD_Cterm; cl10970
323098005938	Transposase; Region: HTH_Tnp_1; pfam01527
323098005939	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323098005940	Helix-turn-helix domain; Region: HTH_28; pfam13518
323098005941	Winged helix-turn helix; Region: HTH_29; pfam13551
323098005942	Homeodomain-like domain; Region: HTH_32; pfam13565
323098005943	Integrase core domain; Region: rve; pfam00665
323098005944	Integrase core domain; Region: rve_3; pfam13683
323098005945	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
323098005946	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
323098005947	Secretin and TonB N terminus short domain; Region: STN; smart00965
323098005948	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
323098005949	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
323098005950	N-terminal plug; other site
323098005951	ligand-binding site [chemical binding]; other site
323098005952	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
323098005953	FecR protein; Region: FecR; pfam04773
323098005954	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
323098005955	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
323098005956	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
323098005957	Protein of unknown function (DUF3016); Region: DUF3016; pfam11454
323098005958	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
323098005959	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
323098005960	Protein of unknown function (DUF3356); Region: DUF3356; pfam11836
323098005961	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
323098005962	Winged helix-turn helix; Region: HTH_29; pfam13551
323098005963	Homeodomain-like domain; Region: HTH_23; cl17451
323098005964	Homeodomain-like domain; Region: HTH_32; pfam13565
323098005965	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323098005966	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323098005967	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
323098005968	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
323098005969	ligand binding site [chemical binding]; other site
323098005970	flexible hinge region; other site
323098005971	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
323098005972	putative switch regulator; other site
323098005973	non-specific DNA interactions [nucleotide binding]; other site
323098005974	DNA binding site [nucleotide binding]
323098005975	sequence specific DNA binding site [nucleotide binding]; other site
323098005976	putative cAMP binding site [chemical binding]; other site
323098005977	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
323098005978	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
323098005979	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
323098005980	putative transporter; Provisional; Region: PRK11660
323098005981	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
323098005982	Sulfate transporter family; Region: Sulfate_transp; pfam00916
323098005983	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
323098005984	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
323098005985	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
323098005986	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
323098005987	[4Fe-4S] binding site [ion binding]; other site
323098005988	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
323098005989	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
323098005990	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
323098005991	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
323098005992	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
323098005993	molybdopterin cofactor binding site; other site
323098005994	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
323098005995	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
323098005996	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
323098005997	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
323098005998	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
323098005999	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
323098006000	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
323098006001	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
323098006002	N-terminal plug; other site
323098006003	ligand-binding site [chemical binding]; other site
323098006004	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
323098006005	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
323098006006	intersubunit interface [polypeptide binding]; other site
323098006007	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
323098006008	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
323098006009	Walker A/P-loop; other site
323098006010	ATP binding site [chemical binding]; other site
323098006011	Q-loop/lid; other site
323098006012	ABC transporter signature motif; other site
323098006013	Walker B; other site
323098006014	D-loop; other site
323098006015	H-loop/switch region; other site
323098006016	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
323098006017	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
323098006018	ABC-ATPase subunit  interface; other site
323098006019	dimer interface [polypeptide binding]; other site
323098006020	putative PBP binding regions; other site
323098006021	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
323098006022	ligand-binding site [chemical binding]; other site
323098006023	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
323098006024	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
323098006025	HipA N-terminal domain; Region: Couple_hipA; cl11853
323098006026	HipA-like N-terminal domain; Region: HipA_N; pfam07805
323098006027	HipA-like C-terminal domain; Region: HipA_C; pfam07804
323098006028	Transposase; Region: HTH_Tnp_1; pfam01527
323098006029	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323098006030	Helix-turn-helix domain; Region: HTH_28; pfam13518
323098006031	Winged helix-turn helix; Region: HTH_29; pfam13551
323098006032	Homeodomain-like domain; Region: HTH_32; pfam13565
323098006033	Integrase core domain; Region: rve; pfam00665
323098006034	Integrase core domain; Region: rve_3; pfam13683
323098006035	Divergent AAA domain; Region: AAA_4; pfam04326
323098006036	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
323098006037	active site
323098006038	catalytic triad [active]
323098006039	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323098006040	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
323098006041	Walker A motif; other site
323098006042	ATP binding site [chemical binding]; other site
323098006043	Walker B motif; other site
323098006044	arginine finger; other site
323098006045	Protein of unknown function (DUF2274); Region: DUF2274; pfam10038
323098006046	Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948
323098006047	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
323098006048	VirB7 interaction site; other site
323098006049	conjugal transfer protein TrbF; Provisional; Region: PRK13872
323098006050	conjugal transfer protein TrbL; Provisional; Region: PRK13875
323098006051	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
323098006052	conjugative transfer region protein TrbK; Region: other_trbK; TIGR04360
323098006053	Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314
323098006054	conjugal transfer protein TrbJ; Provisional; Region: PRK13874
323098006055	conjugal transfer ATPase TrbE; Provisional; Region: PRK13873
323098006056	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
323098006057	Walker A/P-loop; other site
323098006058	ATP binding site [chemical binding]; other site
323098006059	Helix-turn-helix domain; Region: HTH_28; pfam13518
323098006060	Winged helix-turn helix; Region: HTH_29; pfam13551
323098006061	Homeodomain-like domain; Region: HTH_32; pfam13565
323098006062	Integrase core domain; Region: rve; pfam00665
323098006063	Integrase core domain; Region: rve_3; pfam13683
323098006064	Transposase; Region: HTH_Tnp_1; pfam01527
323098006065	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323098006066	Winged helix-turn helix; Region: HTH_29; pfam13551
323098006067	Homeodomain-like domain; Region: HTH_23; cl17451
323098006068	Homeodomain-like domain; Region: HTH_32; pfam13565
323098006069	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323098006070	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323098006071	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
323098006072	DNA binding site [nucleotide binding]
323098006073	active site
323098006074	Int/Topo IB signature motif; other site
323098006075	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
323098006076	Winged helix-turn helix; Region: HTH_29; pfam13551
323098006077	Homeodomain-like domain; Region: HTH_23; cl17451
323098006078	Homeodomain-like domain; Region: HTH_32; pfam13565
323098006079	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323098006080	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323098006081	Fic family protein [Function unknown]; Region: COG3177
323098006082	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
323098006083	Fic/DOC family; Region: Fic; pfam02661
323098006084	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
323098006085	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
323098006086	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
323098006087	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
323098006088	putative ADP-binding pocket [chemical binding]; other site
323098006089	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
323098006090	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
323098006091	ring oligomerisation interface [polypeptide binding]; other site
323098006092	ATP/Mg binding site [chemical binding]; other site
323098006093	stacking interactions; other site
323098006094	hinge regions; other site
323098006095	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
323098006096	oligomerisation interface [polypeptide binding]; other site
323098006097	mobile loop; other site
323098006098	roof hairpin; other site
323098006099	Usg-like family; Region: Usg; cl11567
323098006100	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
323098006101	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
323098006102	putative dimer interface [polypeptide binding]; other site
323098006103	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
323098006104	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
323098006105	putative dimer interface [polypeptide binding]; other site
323098006106	Transposase; Region: HTH_Tnp_1; cl17663
323098006107	putative transposase OrfB; Reviewed; Region: PHA02517
323098006108	HTH-like domain; Region: HTH_21; pfam13276
323098006109	Integrase core domain; Region: rve; pfam00665
323098006110	Integrase core domain; Region: rve_3; pfam13683
323098006111	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
323098006112	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
323098006113	Protein of unknown function (DUF2958); Region: DUF2958; pfam11171
323098006114	ParB-like nuclease domain; Region: ParBc; pfam02195
323098006115	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
323098006116	metal binding site [ion binding]; metal-binding site
323098006117	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323098006118	S-adenosylmethionine binding site [chemical binding]; other site
323098006119	P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872
323098006120	Helicase_C-like; Region: Helicase_C_4; pfam13871
323098006121	Caf1 Capsule antigen; Region: Antig_Caf1; pfam09255
323098006122	Toprim domain; Region: Toprim_3; pfam13362
323098006123	Protein of unknown function (DUF2493); Region: DUF2493; pfam10686
323098006124	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
323098006125	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
323098006126	ATP binding site [chemical binding]; other site
323098006127	putative Mg++ binding site [ion binding]; other site
323098006128	Uncharacterized conserved protein [Function unknown]; Region: COG5489
323098006129	Helix-turn-helix domain; Region: HTH_28; pfam13518
323098006130	Winged helix-turn helix; Region: HTH_29; pfam13551
323098006131	Homeodomain-like domain; Region: HTH_32; pfam13565
323098006132	Integrase core domain; Region: rve; pfam00665
323098006133	Integrase core domain; Region: rve_3; pfam13683
323098006134	Transposase; Region: HTH_Tnp_1; pfam01527
323098006135	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323098006136	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
323098006137	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
323098006138	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
323098006139	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
323098006140	Transcriptional regulator [Transcription]; Region: LysR; COG0583
323098006141	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
323098006142	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930
323098006143	integrase; Provisional; Region: PRK09692
323098006144	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
323098006145	active site
323098006146	Int/Topo IB signature motif; other site
323098006147	GMP synthase; Reviewed; Region: guaA; PRK00074
323098006148	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
323098006149	AMP/PPi binding site [chemical binding]; other site
323098006150	candidate oxyanion hole; other site
323098006151	catalytic triad [active]
323098006152	potential glutamine specificity residues [chemical binding]; other site
323098006153	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
323098006154	ATP Binding subdomain [chemical binding]; other site
323098006155	Ligand Binding sites [chemical binding]; other site
323098006156	Dimerization subdomain; other site
323098006157	ribosomal RNA small subunit methyltransferase RsmB; Region: rsmB; TIGR00563
323098006158	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
323098006159	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
323098006160	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
323098006161	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
323098006162	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
323098006163	active site
323098006164	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323098006165	putative transporter; Provisional; Region: PRK10504
323098006166	putative substrate translocation pore; other site
323098006167	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323098006168	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
323098006169	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323098006170	S-adenosylmethionine binding site [chemical binding]; other site
323098006171	exopolyphosphatase; Region: exo_poly_only; TIGR03706
323098006172	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
323098006173	hypothetical protein; Validated; Region: PRK00124
323098006174	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
323098006175	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
323098006176	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
323098006177	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
323098006178	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
323098006179	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
323098006180	putative active site [active]
323098006181	putative catalytic site [active]
323098006182	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
323098006183	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
323098006184	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
323098006185	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
323098006186	substrate binding site [chemical binding]; other site
323098006187	oxyanion hole (OAH) forming residues; other site
323098006188	trimer interface [polypeptide binding]; other site
323098006189	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
323098006190	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
323098006191	Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162
323098006192	substrate binding pocket [chemical binding]; other site
323098006193	FAD binding site [chemical binding]; other site
323098006194	catalytic base [active]
323098006195	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
323098006196	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
323098006197	tetrameric interface [polypeptide binding]; other site
323098006198	NAD binding site [chemical binding]; other site
323098006199	catalytic residues [active]
323098006200	acetyl-CoA acetyltransferase; Provisional; Region: PRK07516
323098006201	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
323098006202	active site
323098006203	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317
323098006204	Uncharacterized conserved protein [Function unknown]; Region: COG3791
323098006205	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395
323098006206	Protein of unknown function (DUF1491); Region: DUF1491; pfam07372
323098006207	adenylosuccinate lyase; Provisional; Region: PRK07492
323098006208	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
323098006209	tetramer interface [polypeptide binding]; other site
323098006210	active site
323098006211	PilZ domain; Region: PilZ; pfam07238
323098006212	PilZ domain; Region: PilZ; pfam07238
323098006213	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
323098006214	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035
323098006215	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
323098006216	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
323098006217	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
323098006218	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
323098006219	trimer interface [polypeptide binding]; other site
323098006220	putative metal binding site [ion binding]; other site
323098006221	Protein of unknown function (DUF3126); Region: DUF3126; pfam11324
323098006222	serine acetyltransferase; Provisional; Region: cysE; PRK11132
323098006223	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
323098006224	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
323098006225	trimer interface [polypeptide binding]; other site
323098006226	active site
323098006227	substrate binding site [chemical binding]; other site
323098006228	CoA binding site [chemical binding]; other site
323098006229	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
323098006230	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
323098006231	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391
323098006232	salicylate hydroxylase; Provisional; Region: PRK08163
323098006233	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
323098006234	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
323098006235	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
323098006236	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
323098006237	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
323098006238	putative catalytic residue [active]
323098006239	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
323098006240	active site
323098006241	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
323098006242	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
323098006243	putative MPT binding site; other site
323098006244	Usg-like family; Region: Usg; pfam06233
323098006245	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
323098006246	oligomerisation interface [polypeptide binding]; other site
323098006247	mobile loop; other site
323098006248	roof hairpin; other site
323098006249	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
323098006250	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
323098006251	ring oligomerisation interface [polypeptide binding]; other site
323098006252	ATP/Mg binding site [chemical binding]; other site
323098006253	stacking interactions; other site
323098006254	hinge regions; other site
323098006255	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
323098006256	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
323098006257	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
323098006258	Ligand binding site; other site
323098006259	Putative Catalytic site; other site
323098006260	DXD motif; other site
323098006261	Predicted membrane protein [Function unknown]; Region: COG2246
323098006262	GtrA-like protein; Region: GtrA; pfam04138
323098006263	Protein of unknown function DUF72; Region: DUF72; pfam01904
323098006264	Protein of unknown function, DUF488; Region: DUF488; pfam04343
323098006265	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
323098006266	putative MPT binding site; other site
323098006267	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
323098006268	Ligand binding site; other site
323098006269	metal-binding site
323098006270	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
323098006271	XdhC Rossmann domain; Region: XdhC_C; pfam13478
323098006272	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
323098006273	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
323098006274	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
323098006275	metal ion-dependent adhesion site (MIDAS); other site
323098006276	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323098006277	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
323098006278	Walker A motif; other site
323098006279	ATP binding site [chemical binding]; other site
323098006280	Walker B motif; other site
323098006281	arginine finger; other site
323098006282	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
323098006283	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
323098006284	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
323098006285	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
323098006286	catalytic loop [active]
323098006287	iron binding site [ion binding]; other site
323098006288	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
323098006289	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
323098006290	putative hydrophobic ligand binding site [chemical binding]; other site
323098006291	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
323098006292	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
323098006293	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
323098006294	TM-ABC transporter signature motif; other site
323098006295	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
323098006296	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
323098006297	TM-ABC transporter signature motif; other site
323098006298	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
323098006299	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
323098006300	Walker A/P-loop; other site
323098006301	ATP binding site [chemical binding]; other site
323098006302	Q-loop/lid; other site
323098006303	ABC transporter signature motif; other site
323098006304	Walker B; other site
323098006305	D-loop; other site
323098006306	H-loop/switch region; other site
323098006307	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
323098006308	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
323098006309	Walker A/P-loop; other site
323098006310	ATP binding site [chemical binding]; other site
323098006311	Q-loop/lid; other site
323098006312	ABC transporter signature motif; other site
323098006313	Walker B; other site
323098006314	D-loop; other site
323098006315	H-loop/switch region; other site
323098006316	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
323098006317	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
323098006318	dimerization interface [polypeptide binding]; other site
323098006319	ligand binding site [chemical binding]; other site
323098006320	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
323098006321	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
323098006322	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
323098006323	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
323098006324	cleavage site
323098006325	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
323098006326	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
323098006327	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
323098006328	substrate binding site [chemical binding]; other site
323098006329	hexamer interface [polypeptide binding]; other site
323098006330	metal binding site [ion binding]; metal-binding site
323098006331	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
323098006332	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
323098006333	N-terminal plug; other site
323098006334	ligand-binding site [chemical binding]; other site
323098006335	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
323098006336	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
323098006337	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323098006338	putative active site [active]
323098006339	heme pocket [chemical binding]; other site
323098006340	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323098006341	dimer interface [polypeptide binding]; other site
323098006342	phosphorylation site [posttranslational modification]
323098006343	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323098006344	ATP binding site [chemical binding]; other site
323098006345	Mg2+ binding site [ion binding]; other site
323098006346	G-X-G motif; other site
323098006347	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
323098006348	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323098006349	Winged helix-turn helix; Region: HTH_29; pfam13551
323098006350	Integrase core domain; Region: rve; pfam00665
323098006351	Integrase core domain; Region: rve_3; pfam13683
323098006352	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
323098006353	DnaA box-binding interface [nucleotide binding]; other site
323098006354	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
323098006355	Interleukin 11; Region: IL11; pfam07400
323098006356	hypothetical protein; Validated; Region: PRK09104
323098006357	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
323098006358	metal binding site [ion binding]; metal-binding site
323098006359	putative dimer interface [polypeptide binding]; other site
323098006360	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
323098006361	Domain of unknown function DUF87; Region: DUF87; pfam01935
323098006362	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
323098006363	Domain of unknown function (DUF4332); Region: DUF4332; pfam14229
323098006364	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
323098006365	dihydropteroate synthase; Region: DHPS; TIGR01496
323098006366	substrate binding pocket [chemical binding]; other site
323098006367	dimer interface [polypeptide binding]; other site
323098006368	inhibitor binding site; inhibition site
323098006369	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
323098006370	homooctamer interface [polypeptide binding]; other site
323098006371	active site
323098006372	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
323098006373	catalytic center binding site [active]
323098006374	ATP binding site [chemical binding]; other site
323098006375	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
323098006376	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
323098006377	heterodimer interface [polypeptide binding]; other site
323098006378	substrate interaction site [chemical binding]; other site
323098006379	Uncharacterized conserved protein [Function unknown]; Region: COG3791
323098006380	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
323098006381	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
323098006382	active site
323098006383	substrate binding site [chemical binding]; other site
323098006384	coenzyme B12 binding site [chemical binding]; other site
323098006385	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
323098006386	B12 binding site [chemical binding]; other site
323098006387	cobalt ligand [ion binding]; other site
323098006388	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
323098006389	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
323098006390	membrane ATPase/protein kinase; Provisional; Region: PRK09435
323098006391	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
323098006392	Walker A; other site
323098006393	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237
323098006394	putative substrate binding pocket [chemical binding]; other site
323098006395	AC domain interface; other site
323098006396	catalytic triad [active]
323098006397	AB domain interface; other site
323098006398	interchain disulfide; other site
323098006399	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
323098006400	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323098006401	putative substrate translocation pore; other site
323098006402	twin-arg-translocated uncharacterized repeat protein; Region: RR_plus_rpt_1; TIGR03808
323098006403	putative cofactor-binding repeat; Region: RR_fam_repeat; TIGR03807
323098006404	TIGR03809 family protein; Region: TIGR03809
323098006405	CsbD-like; Region: CsbD; cl17424
323098006406	Peptidase S8 family domain, uncharacterized subfamily 4; Region: Peptidases_S8_4; cd05561
323098006407	active site
323098006408	catalytic triad [active]
323098006409	RNA polymerase sigma factor; Provisional; Region: PRK12515
323098006410	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
323098006411	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
323098006412	DNA binding residues [nucleotide binding]
323098006413	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
323098006414	enoyl-CoA hydratase; Provisional; Region: PRK05862
323098006415	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
323098006416	substrate binding site [chemical binding]; other site
323098006417	oxyanion hole (OAH) forming residues; other site
323098006418	trimer interface [polypeptide binding]; other site
323098006419	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
323098006420	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
323098006421	threonine dehydratase; Provisional; Region: PRK07334
323098006422	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
323098006423	tetramer interface [polypeptide binding]; other site
323098006424	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323098006425	catalytic residue [active]
323098006426	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
323098006427	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
323098006428	putative active site [active]
323098006429	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
323098006430	putative PHP Thumb interface [polypeptide binding]; other site
323098006431	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
323098006432	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
323098006433	generic binding surface I; other site
323098006434	generic binding surface II; other site
323098006435	DNA Polymerase Y-family; Region: PolY_like; cd03468
323098006436	active site
323098006437	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
323098006438	DNA binding site [nucleotide binding]
323098006439	Uncharacterized conserved protein [Function unknown]; Region: COG4544
323098006440	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
323098006441	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
323098006442	FeS/SAM binding site; other site
323098006443	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
323098006444	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323098006445	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323098006446	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
323098006447	Fe-S cluster binding site [ion binding]; other site
323098006448	active site
323098006449	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
323098006450	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
323098006451	metal binding site [ion binding]; metal-binding site
323098006452	putative dimer interface [polypeptide binding]; other site
323098006453	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
323098006454	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
323098006455	inhibitor-cofactor binding pocket; inhibition site
323098006456	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323098006457	catalytic residue [active]
323098006458	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
323098006459	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
323098006460	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
323098006461	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
323098006462	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
323098006463	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
323098006464	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
323098006465	FeS/SAM binding site; other site
323098006466	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
323098006467	hypothetical protein; Provisional; Region: PRK07077
323098006468	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
323098006469	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
323098006470	Active site cavity [active]
323098006471	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
323098006472	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
323098006473	active site lid residues [active]
323098006474	substrate binding pocket [chemical binding]; other site
323098006475	catalytic residues [active]
323098006476	substrate-Mg2+ binding site; other site
323098006477	aspartate-rich region 1; other site
323098006478	aspartate-rich region 2; other site
323098006479	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
323098006480	active site lid residues [active]
323098006481	substrate binding pocket [chemical binding]; other site
323098006482	catalytic residues [active]
323098006483	substrate-Mg2+ binding site; other site
323098006484	aspartate-rich region 1; other site
323098006485	aspartate-rich region 2; other site
323098006486	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
323098006487	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
323098006488	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
323098006489	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
323098006490	B12 binding site [chemical binding]; other site
323098006491	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
323098006492	amidase; Provisional; Region: PRK07056
323098006493	Amidase; Region: Amidase; cl11426
323098006494	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
323098006495	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
323098006496	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
323098006497	Cytochrome P450; Region: p450; cl12078
323098006498	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
323098006499	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
323098006500	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
323098006501	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
323098006502	hydroxyglutarate oxidase; Provisional; Region: PRK11728
323098006503	multidrug efflux protein; Reviewed; Region: PRK09579
323098006504	Protein export membrane protein; Region: SecD_SecF; cl14618
323098006505	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
323098006506	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
323098006507	HlyD family secretion protein; Region: HlyD_3; pfam13437
323098006508	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
323098006509	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
323098006510	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
323098006511	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
323098006512	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
323098006513	NAD(P) binding site [chemical binding]; other site
323098006514	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
323098006515	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
323098006516	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
323098006517	Beta-lactamase; Region: Beta-lactamase; pfam00144
323098006518	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
323098006519	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
323098006520	putative active site [active]
323098006521	putative catalytic site [active]
323098006522	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981
323098006523	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
323098006524	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
323098006525	N-terminal plug; other site
323098006526	ligand-binding site [chemical binding]; other site
323098006527	putative acetyltransferase YhhY; Provisional; Region: PRK10140
323098006528	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
323098006529	Coenzyme A binding pocket [chemical binding]; other site
323098006530	Secretin and TonB N terminus short domain; Region: STN; smart00965
323098006531	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
323098006532	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
323098006533	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
323098006534	FecR protein; Region: FecR; pfam04773
323098006535	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
323098006536	A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399
323098006537	acyl-CoA synthetase; Validated; Region: PRK08308
323098006538	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
323098006539	active site
323098006540	CoA binding site [chemical binding]; other site
323098006541	AMP binding site [chemical binding]; other site
323098006542	IucA / IucC family; Region: IucA_IucC; pfam04183
323098006543	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
323098006544	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
323098006545	IucA / IucC family; Region: IucA_IucC; pfam04183
323098006546	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
323098006547	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
323098006548	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
323098006549	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
323098006550	DNA binding residues [nucleotide binding]
323098006551	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
323098006552	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
323098006553	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
323098006554	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
323098006555	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
323098006556	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
323098006557	short chain dehydrogenase; Provisional; Region: PRK07109
323098006558	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
323098006559	putative NAD(P) binding site [chemical binding]; other site
323098006560	active site
323098006561	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
323098006562	Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
323098006563	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
323098006564	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
323098006565	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
323098006566	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
323098006567	D-pathway; other site
323098006568	Putative ubiquinol binding site [chemical binding]; other site
323098006569	Low-spin heme (heme b) binding site [chemical binding]; other site
323098006570	Putative water exit pathway; other site
323098006571	Binuclear center (heme o3/CuB) [ion binding]; other site
323098006572	K-pathway; other site
323098006573	Putative proton exit pathway; other site
323098006574	Predicted membrane protein (DUF2231); Region: DUF2231; pfam09990
323098006575	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
323098006576	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
323098006577	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
323098006578	N-terminal plug; other site
323098006579	ligand-binding site [chemical binding]; other site
323098006580	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
323098006581	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
323098006582	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
323098006583	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
323098006584	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
323098006585	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
323098006586	Amidinotransferase; Region: Amidinotransf; cl12043
323098006587	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
323098006588	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
323098006589	Walker A/P-loop; other site
323098006590	ATP binding site [chemical binding]; other site
323098006591	Q-loop/lid; other site
323098006592	ABC transporter signature motif; other site
323098006593	Walker B; other site
323098006594	D-loop; other site
323098006595	H-loop/switch region; other site
323098006596	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
323098006597	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
323098006598	ABC-ATPase subunit  interface; other site
323098006599	dimer interface [polypeptide binding]; other site
323098006600	putative PBP binding regions; other site
323098006601	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
323098006602	intersubunit interface [polypeptide binding]; other site
323098006603	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
323098006604	putative heme utilization carrier protein HutX; Region: HutX; TIGR04108
323098006605	hypothetical protein; Provisional; Region: PRK06185
323098006606	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
323098006607	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
323098006608	Helix-turn-helix domain; Region: HTH_28; pfam13518
323098006609	Winged helix-turn helix; Region: HTH_29; pfam13551
323098006610	Homeodomain-like domain; Region: HTH_32; pfam13565
323098006611	Integrase core domain; Region: rve; pfam00665
323098006612	Integrase core domain; Region: rve_3; pfam13683
323098006613	Transposase; Region: HTH_Tnp_1; cl17663
323098006614	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323098006615	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
323098006616	HD domain; Region: HD_4; pfam13328
323098006617	Protein of unknown function (DUF3489); Region: DUF3489; pfam11994
323098006618	Protein of unknown function (DUF2924); Region: DUF2924; pfam11149
323098006619	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
323098006620	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
323098006621	catalytic residues [active]
323098006622	catalytic nucleophile [active]
323098006623	Presynaptic Site I dimer interface [polypeptide binding]; other site
323098006624	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
323098006625	Synaptic Flat tetramer interface [polypeptide binding]; other site
323098006626	Synaptic Site I dimer interface [polypeptide binding]; other site
323098006627	DNA binding site [nucleotide binding]
323098006628	Recombinase; Region: Recombinase; pfam07508
323098006629	2-isopropylmalate synthase; Validated; Region: PRK00915
323098006630	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
323098006631	active site
323098006632	catalytic residues [active]
323098006633	metal binding site [ion binding]; metal-binding site
323098006634	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
323098006635	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
323098006636	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
323098006637	Walker A/P-loop; other site
323098006638	ATP binding site [chemical binding]; other site
323098006639	Q-loop/lid; other site
323098006640	ABC transporter signature motif; other site
323098006641	Walker B; other site
323098006642	D-loop; other site
323098006643	H-loop/switch region; other site
323098006644	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
323098006645	dimer interface [polypeptide binding]; other site
323098006646	conserved gate region; other site
323098006647	putative PBP binding loops; other site
323098006648	ABC-ATPase subunit interface; other site
323098006649	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
323098006650	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
323098006651	ketol-acid reductoisomerase; Provisional; Region: PRK05479
323098006652	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
323098006653	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
323098006654	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
323098006655	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
323098006656	putative valine binding site [chemical binding]; other site
323098006657	dimer interface [polypeptide binding]; other site
323098006658	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
323098006659	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
323098006660	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
323098006661	PYR/PP interface [polypeptide binding]; other site
323098006662	dimer interface [polypeptide binding]; other site
323098006663	TPP binding site [chemical binding]; other site
323098006664	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
323098006665	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
323098006666	TPP-binding site [chemical binding]; other site
323098006667	dimer interface [polypeptide binding]; other site
323098006668	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
323098006669	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
323098006670	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
323098006671	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
323098006672	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
323098006673	motif II; other site
323098006674	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
323098006675	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
323098006676	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
323098006677	protein binding site [polypeptide binding]; other site
323098006678	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
323098006679	protein binding site [polypeptide binding]; other site
323098006680	Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; cl01275
323098006681	FtsH protease regulator HflC; Provisional; Region: PRK11029
323098006682	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
323098006683	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
323098006684	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
323098006685	HflK protein; Region: hflK; TIGR01933
323098006686	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
323098006687	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
323098006688	folate binding site [chemical binding]; other site
323098006689	NADP+ binding site [chemical binding]; other site
323098006690	thymidylate synthase; Reviewed; Region: thyA; PRK01827
323098006691	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
323098006692	dimerization interface [polypeptide binding]; other site
323098006693	active site
323098006694	Stringent starvation protein B; Region: SspB; pfam04386
323098006695	fumarate hydratase; Reviewed; Region: fumC; PRK00485
323098006696	Class II fumarases; Region: Fumarase_classII; cd01362
323098006697	active site
323098006698	tetramer interface [polypeptide binding]; other site
323098006699	Domain of unknown function (DUF4169); Region: DUF4169; pfam13770
323098006700	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
323098006701	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
323098006702	Transposase; Region: HTH_Tnp_1; pfam01527
323098006703	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323098006704	Helix-turn-helix domain; Region: HTH_28; pfam13518
323098006705	Winged helix-turn helix; Region: HTH_29; pfam13551
323098006706	Homeodomain-like domain; Region: HTH_32; pfam13565
323098006707	Integrase core domain; Region: rve; pfam00665
323098006708	Integrase core domain; Region: rve_3; pfam13683
323098006709	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
323098006710	Part of AAA domain; Region: AAA_19; pfam13245
323098006711	Family description; Region: UvrD_C_2; pfam13538
323098006712	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
323098006713	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
323098006714	Walker A/P-loop; other site
323098006715	ATP binding site [chemical binding]; other site
323098006716	Q-loop/lid; other site
323098006717	ABC transporter signature motif; other site
323098006718	Walker B; other site
323098006719	D-loop; other site
323098006720	H-loop/switch region; other site
323098006721	ABC-2 type transporter; Region: ABC2_membrane; cl17235
323098006722	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
323098006723	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
323098006724	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
323098006725	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
323098006726	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323098006727	S-adenosylmethionine binding site [chemical binding]; other site
323098006728	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
323098006729	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
323098006730	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
323098006731	active site
323098006732	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323098006733	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323098006734	Winged helix-turn helix; Region: HTH_29; pfam13551
323098006735	Homeodomain-like domain; Region: HTH_23; cl17451
323098006736	Homeodomain-like domain; Region: HTH_32; pfam13565
323098006737	Protein of unknown function (DUF972); Region: DUF972; pfam06156
323098006738	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
323098006739	DNA-binding site [nucleotide binding]; DNA binding site
323098006740	RNA-binding motif; other site
323098006741	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
323098006742	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
323098006743	homotetramer interface [polypeptide binding]; other site
323098006744	ligand binding site [chemical binding]; other site
323098006745	catalytic site [active]
323098006746	NAD binding site [chemical binding]; other site
323098006747	S-adenosylmethionine synthetase; Validated; Region: PRK05250
323098006748	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
323098006749	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
323098006750	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
323098006751	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
323098006752	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
323098006753	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
323098006754	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
323098006755	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
323098006756	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
323098006757	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
323098006758	putative active site [active]
323098006759	putative substrate binding site [chemical binding]; other site
323098006760	putative cosubstrate binding site; other site
323098006761	catalytic site [active]
323098006762	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
323098006763	Mg++ binding site [ion binding]; other site
323098006764	putative catalytic motif [active]
323098006765	putative substrate binding site [chemical binding]; other site
323098006766	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
323098006767	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
323098006768	NADP binding site [chemical binding]; other site
323098006769	active site
323098006770	putative substrate binding site [chemical binding]; other site
323098006771	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
323098006772	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
323098006773	NADP-binding site; other site
323098006774	homotetramer interface [polypeptide binding]; other site
323098006775	substrate binding site [chemical binding]; other site
323098006776	homodimer interface [polypeptide binding]; other site
323098006777	active site
323098006778	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
323098006779	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
323098006780	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
323098006781	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323098006782	NAD(P) binding site [chemical binding]; other site
323098006783	active site
323098006784	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
323098006785	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
323098006786	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
323098006787	catalytic residue [active]
323098006788	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
323098006789	putative trimer interface [polypeptide binding]; other site
323098006790	putative CoA binding site [chemical binding]; other site
323098006791	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
323098006792	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
323098006793	substrate binding site [chemical binding]; other site
323098006794	glutamase interaction surface [polypeptide binding]; other site
323098006795	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
323098006796	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
323098006797	putative active site [active]
323098006798	oxyanion strand; other site
323098006799	catalytic triad [active]
323098006800	N-acetyl sugar amidotransferase; Region: WbuX; TIGR03573
323098006801	Ligand Binding Site [chemical binding]; other site
323098006802	flagellin modification protein A; Provisional; Region: PRK09186
323098006803	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323098006804	NAD(P) binding site [chemical binding]; other site
323098006805	active site
323098006806	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607
323098006807	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
323098006808	NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426
323098006809	Substrate binding site; other site
323098006810	metal-binding site
323098006811	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
323098006812	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
323098006813	putative trimer interface [polypeptide binding]; other site
323098006814	putative CoA binding site [chemical binding]; other site
323098006815	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
323098006816	NeuB family; Region: NeuB; pfam03102
323098006817	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
323098006818	NeuB binding interface [polypeptide binding]; other site
323098006819	putative substrate binding site [chemical binding]; other site
323098006820	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
323098006821	ligand binding site; other site
323098006822	tetramer interface; other site
323098006823	UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568
323098006824	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
323098006825	active site
323098006826	homodimer interface [polypeptide binding]; other site
323098006827	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
323098006828	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
323098006829	extended (e) SDRs; Region: SDR_e; cd08946
323098006830	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
323098006831	NAD(P) binding site [chemical binding]; other site
323098006832	active site
323098006833	substrate binding site [chemical binding]; other site
323098006834	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
323098006835	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
323098006836	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
323098006837	inhibitor-cofactor binding pocket; inhibition site
323098006838	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323098006839	catalytic residue [active]
323098006840	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
323098006841	NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180
323098006842	NAD binding site [chemical binding]; other site
323098006843	substrate binding site [chemical binding]; other site
323098006844	active site
323098006845	Helix-turn-helix domain; Region: HTH_28; pfam13518
323098006846	putative transposase OrfB; Reviewed; Region: PHA02517
323098006847	Homeodomain-like domain; Region: HTH_32; pfam13565
323098006848	Integrase core domain; Region: rve; pfam00665
323098006849	Integrase core domain; Region: rve_3; pfam13683
323098006850	Transposase; Region: HTH_Tnp_1; pfam01527
323098006851	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323098006852	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
323098006853	Methyltransferase domain; Region: Methyltransf_31; pfam13847
323098006854	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323098006855	S-adenosylmethionine binding site [chemical binding]; other site
323098006856	O-Antigen ligase; Region: Wzy_C; pfam04932
323098006857	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323098006858	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323098006859	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323098006860	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
323098006861	homodimer interface [polypeptide binding]; other site
323098006862	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323098006863	catalytic residue [active]
323098006864	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
323098006865	HIT family signature motif; other site
323098006866	catalytic residue [active]
323098006867	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
323098006868	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
323098006869	ligand binding site [chemical binding]; other site
323098006870	flexible hinge region; other site
323098006871	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
323098006872	putative switch regulator; other site
323098006873	non-specific DNA interactions [nucleotide binding]; other site
323098006874	DNA binding site [nucleotide binding]
323098006875	sequence specific DNA binding site [nucleotide binding]; other site
323098006876	putative cAMP binding site [chemical binding]; other site
323098006877	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
323098006878	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
323098006879	inhibitor-cofactor binding pocket; inhibition site
323098006880	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323098006881	catalytic residue [active]
323098006882	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
323098006883	AAA domain; Region: AAA_26; pfam13500
323098006884	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
323098006885	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
323098006886	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
323098006887	catalytic residue [active]
323098006888	Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876
323098006889	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
323098006890	quinolinate synthetase; Provisional; Region: PRK09375
323098006891	L-aspartate oxidase; Provisional; Region: PRK07512
323098006892	L-aspartate oxidase; Provisional; Region: PRK06175
323098006893	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
323098006894	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106
323098006895	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
323098006896	dimerization interface [polypeptide binding]; other site
323098006897	active site
323098006898	PRC-barrel domain; Region: PRC; pfam05239
323098006899	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
323098006900	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
323098006901	metal binding site [ion binding]; metal-binding site
323098006902	active site
323098006903	I-site; other site
323098006904	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
323098006905	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
323098006906	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
323098006907	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
323098006908	DNA binding residues [nucleotide binding]
323098006909	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
323098006910	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
323098006911	RNA binding surface [nucleotide binding]; other site
323098006912	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
323098006913	active site
323098006914	Helix-turn-helix domain; Region: HTH_28; pfam13518
323098006915	putative transposase OrfB; Reviewed; Region: PHA02517
323098006916	Homeodomain-like domain; Region: HTH_32; pfam13565
323098006917	Integrase core domain; Region: rve; pfam00665
323098006918	Integrase core domain; Region: rve_3; pfam13683
323098006919	Transposase; Region: HTH_Tnp_1; pfam01527
323098006920	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323098006921	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
323098006922	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323098006923	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323098006924	murein hydrolase B; Provisional; Region: PRK10760; cl17906
323098006925	Transglycosylase SLT domain; Region: SLT_2; pfam13406
323098006926	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
323098006927	N-acetyl-D-glucosamine binding site [chemical binding]; other site
323098006928	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
323098006929	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
323098006930	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
323098006931	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
323098006932	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
323098006933	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
323098006934	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
323098006935	DNA binding residues [nucleotide binding]
323098006936	DNA primase; Validated; Region: dnaG; PRK05667
323098006937	CHC2 zinc finger; Region: zf-CHC2; pfam01807
323098006938	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
323098006939	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
323098006940	active site
323098006941	metal binding site [ion binding]; metal-binding site
323098006942	interdomain interaction site; other site
323098006943	Chlorite dismutase; Region: Chlor_dismutase; cl01280
323098006944	N-formylglutamate amidohydrolase; Region: FGase; cl01522
323098006945	Yqey-like protein; Region: YqeY; pfam09424
323098006946	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
323098006947	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
323098006948	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
323098006949	catalytic site [active]
323098006950	subunit interface [polypeptide binding]; other site
323098006951	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
323098006952	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
323098006953	dimerization interface [polypeptide binding]; other site
323098006954	DPS ferroxidase diiron center [ion binding]; other site
323098006955	ion pore; other site
323098006956	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323098006957	S-adenosylmethionine binding site [chemical binding]; other site
323098006958	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
323098006959	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
323098006960	ATP-grasp domain; Region: ATP-grasp_4; cl17255
323098006961	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
323098006962	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
323098006963	ATP-grasp domain; Region: ATP-grasp_4; cl17255
323098006964	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
323098006965	IMP binding site; other site
323098006966	dimer interface [polypeptide binding]; other site
323098006967	interdomain contacts; other site
323098006968	partial ornithine binding site; other site
323098006969	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
323098006970	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
323098006971	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
323098006972	Predicted membrane protein [Function unknown]; Region: COG2259
323098006973	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
323098006974	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
323098006975	putative DNA binding site [nucleotide binding]; other site
323098006976	putative Zn2+ binding site [ion binding]; other site
323098006977	AsnC family; Region: AsnC_trans_reg; pfam01037
323098006978	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
323098006979	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
323098006980	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
323098006981	Transcriptional regulator [Transcription]; Region: LysR; COG0583
323098006982	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
323098006983	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
323098006984	putative effector binding pocket; other site
323098006985	dimerization interface [polypeptide binding]; other site
323098006986	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
323098006987	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
323098006988	P-loop; other site
323098006989	Magnesium ion binding site [ion binding]; other site
323098006990	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
323098006991	Domain of unknown function (DUF4403); Region: DUF4403; pfam14356
323098006992	Dodecin; Region: Dodecin; pfam07311
323098006993	PRC-barrel domain; Region: PRC; pfam05239
323098006994	PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379
323098006995	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
323098006996	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
323098006997	N-acetyl-D-glucosamine binding site [chemical binding]; other site
323098006998	catalytic residue [active]
323098006999	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
323098007000	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
323098007001	thiS-thiF/thiG interaction site; other site
323098007002	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
323098007003	ThiS interaction site; other site
323098007004	putative active site [active]
323098007005	tetramer interface [polypeptide binding]; other site
323098007006	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
323098007007	active site
323098007008	thiamine phosphate binding site [chemical binding]; other site
323098007009	pyrophosphate binding site [ion binding]; other site
323098007010	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
323098007011	ThiC-associated domain; Region: ThiC-associated; pfam13667
323098007012	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
323098007013	Protein of unknown function (DUF3829); Region: DUF3829; pfam12889
323098007014	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
323098007015	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
323098007016	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
323098007017	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323098007018	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
323098007019	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323098007020	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
323098007021	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
323098007022	heme binding site [chemical binding]; other site
323098007023	ferroxidase pore; other site
323098007024	ferroxidase diiron center [ion binding]; other site
323098007025	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
323098007026	lytic murein transglycosylase; Region: MltB_2; TIGR02283
323098007027	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
323098007028	N-acetyl-D-glucosamine binding site [chemical binding]; other site
323098007029	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
323098007030	hypothetical protein; Provisional; Region: PRK05208
323098007031	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
323098007032	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323098007033	S-adenosylmethionine binding site [chemical binding]; other site
323098007034	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
323098007035	Domain of unknown function DUF20; Region: UPF0118; pfam01594
323098007036	Protein of unknown function (DUF497); Region: DUF497; pfam04365
323098007037	Protein of unknown function (DUF3680); Region: DUF3680; pfam12441
323098007038	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
323098007039	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
323098007040	Walker A/P-loop; other site
323098007041	ATP binding site [chemical binding]; other site
323098007042	Q-loop/lid; other site
323098007043	ABC transporter signature motif; other site
323098007044	Walker B; other site
323098007045	D-loop; other site
323098007046	H-loop/switch region; other site
323098007047	ABC transporter; Region: ABC_tran_2; pfam12848
323098007048	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
323098007049	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
323098007050	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
323098007051	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
323098007052	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
323098007053	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
323098007054	active site residue [active]
323098007055	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
323098007056	active site residue [active]
323098007057	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
323098007058	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
323098007059	PAS fold; Region: PAS_7; pfam12860
323098007060	Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375
323098007061	excinuclease ABC subunit B; Provisional; Region: PRK05298
323098007062	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
323098007063	ATP binding site [chemical binding]; other site
323098007064	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
323098007065	nucleotide binding region [chemical binding]; other site
323098007066	ATP-binding site [chemical binding]; other site
323098007067	Ultra-violet resistance protein B; Region: UvrB; pfam12344
323098007068	UvrB/uvrC motif; Region: UVR; pfam02151
323098007069	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323098007070	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
323098007071	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323098007072	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
323098007073	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
323098007074	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
323098007075	active site
323098007076	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
323098007077	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
323098007078	Uncharacterized conserved protein [Function unknown]; Region: COG1565
323098007079	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
323098007080	Membrane fusogenic activity; Region: BMFP; pfam04380
323098007081	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
323098007082	putative active site [active]
323098007083	putative catalytic site [active]
323098007084	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
323098007085	putative active site [active]
323098007086	putative catalytic site [active]
323098007087	Domain of unknown function (DUF4282); Region: DUF4282; pfam14110
323098007088	GTP-binding protein YchF; Reviewed; Region: PRK09601
323098007089	YchF GTPase; Region: YchF; cd01900
323098007090	G1 box; other site
323098007091	GTP/Mg2+ binding site [chemical binding]; other site
323098007092	Switch I region; other site
323098007093	G2 box; other site
323098007094	Switch II region; other site
323098007095	G3 box; other site
323098007096	G4 box; other site
323098007097	G5 box; other site
323098007098	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
323098007099	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
323098007100	putative active site [active]
323098007101	catalytic residue [active]
323098007102	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
323098007103	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
323098007104	5S rRNA interface [nucleotide binding]; other site
323098007105	CTC domain interface [polypeptide binding]; other site
323098007106	L16 interface [polypeptide binding]; other site
323098007107	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
323098007108	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
323098007109	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
323098007110	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
323098007111	aldehyde dehydrogenase family 7 member; Region: PLN02315
323098007112	tetrameric interface [polypeptide binding]; other site
323098007113	NAD binding site [chemical binding]; other site
323098007114	catalytic residues [active]
323098007115	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
323098007116	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
323098007117	inhibitor-cofactor binding pocket; inhibition site
323098007118	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323098007119	catalytic residue [active]
323098007120	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
323098007121	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
323098007122	dimerization interface [polypeptide binding]; other site
323098007123	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323098007124	dimer interface [polypeptide binding]; other site
323098007125	phosphorylation site [posttranslational modification]
323098007126	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323098007127	ATP binding site [chemical binding]; other site
323098007128	Mg2+ binding site [ion binding]; other site
323098007129	G-X-G motif; other site
323098007130	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
323098007131	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323098007132	active site
323098007133	phosphorylation site [posttranslational modification]
323098007134	intermolecular recognition site; other site
323098007135	dimerization interface [polypeptide binding]; other site
323098007136	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
323098007137	DNA binding site [nucleotide binding]
323098007138	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
323098007139	MarR family; Region: MarR_2; pfam12802
323098007140	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
323098007141	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
323098007142	homodimer interface [polypeptide binding]; other site
323098007143	substrate-cofactor binding pocket; other site
323098007144	catalytic residue [active]
323098007145	multidrug efflux protein; Reviewed; Region: PRK01766
323098007146	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
323098007147	cation binding site [ion binding]; other site
323098007148	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
323098007149	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323098007150	S-adenosylmethionine binding site [chemical binding]; other site
323098007151	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
323098007152	MoaE homodimer interface [polypeptide binding]; other site
323098007153	MoaD interaction [polypeptide binding]; other site
323098007154	active site residues [active]
323098007155	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
323098007156	MoaE interaction surface [polypeptide binding]; other site
323098007157	MoeB interaction surface [polypeptide binding]; other site
323098007158	thiocarboxylated glycine; other site
323098007159	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
323098007160	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
323098007161	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
323098007162	GIY-YIG motif/motif A; other site
323098007163	active site
323098007164	catalytic site [active]
323098007165	putative DNA binding site [nucleotide binding]; other site
323098007166	metal binding site [ion binding]; metal-binding site
323098007167	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
323098007168	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
323098007169	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
323098007170	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
323098007171	B1 nucleotide binding pocket [chemical binding]; other site
323098007172	B2 nucleotide binding pocket [chemical binding]; other site
323098007173	CAS motifs; other site
323098007174	active site
323098007175	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
323098007176	histidyl-tRNA synthetase; Region: hisS; TIGR00442
323098007177	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
323098007178	dimer interface [polypeptide binding]; other site
323098007179	motif 1; other site
323098007180	motif 2; other site
323098007181	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
323098007182	active site
323098007183	motif 3; other site
323098007184	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
323098007185	anticodon binding site; other site
323098007186	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
323098007187	putative active site [active]
323098007188	Predicted membrane protein [Function unknown]; Region: COG4655
323098007189	Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977
323098007190	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
323098007191	TadE-like protein; Region: TadE; pfam07811
323098007192	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
323098007193	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
323098007194	inhibitor-cofactor binding pocket; inhibition site
323098007195	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323098007196	catalytic residue [active]
323098007197	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
323098007198	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
323098007199	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
323098007200	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
323098007201	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
323098007202	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323098007203	active site
323098007204	phosphorylation site [posttranslational modification]
323098007205	intermolecular recognition site; other site
323098007206	dimerization interface [polypeptide binding]; other site
323098007207	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
323098007208	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
323098007209	active site
323098007210	Riboflavin kinase; Region: Flavokinase; smart00904
323098007211	isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804
323098007212	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
323098007213	active site
323098007214	HIGH motif; other site
323098007215	nucleotide binding site [chemical binding]; other site
323098007216	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
323098007217	active site
323098007218	KMSKS motif; other site
323098007219	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
323098007220	tRNA binding surface [nucleotide binding]; other site
323098007221	anticodon binding site; other site
323098007222	lipoprotein signal peptidase; Provisional; Region: PRK14796
323098007223	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
323098007224	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
323098007225	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
323098007226	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
323098007227	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
323098007228	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
323098007229	hypothetical protein; Provisional; Region: PRK09256
323098007230	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
323098007231	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
323098007232	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323098007233	ATP binding site [chemical binding]; other site
323098007234	Mg2+ binding site [ion binding]; other site
323098007235	G-X-G motif; other site
323098007236	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
323098007237	ATP binding site [chemical binding]; other site
323098007238	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
323098007239	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
323098007240	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
323098007241	S-adenosylmethionine binding site [chemical binding]; other site
323098007242	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
323098007243	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
323098007244	RNA binding surface [nucleotide binding]; other site
323098007245	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
323098007246	active site
323098007247	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
323098007248	nucleoside/Zn binding site; other site
323098007249	dimer interface [polypeptide binding]; other site
323098007250	catalytic motif [active]
323098007251	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
323098007252	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
323098007253	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
323098007254	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
323098007255	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
323098007256	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
323098007257	generic binding surface II; other site
323098007258	generic binding surface I; other site
323098007259	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908
323098007260	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
323098007261	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
323098007262	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
323098007263	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
323098007264	putative acyl-acceptor binding pocket; other site
323098007265	Domain of unknown function (DUF4170); Region: DUF4170; pfam13773
323098007266	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
323098007267	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
323098007268	active site
323098007269	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
323098007270	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878
323098007271	UbiA prenyltransferase family; Region: UbiA; pfam01040
323098007272	RNA methyltransferase, RsmE family; Region: TIGR00046
323098007273	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
323098007274	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295
323098007275	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
323098007276	dimer interface [polypeptide binding]; other site
323098007277	motif 1; other site
323098007278	motif 2; other site
323098007279	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
323098007280	active site
323098007281	motif 3; other site
323098007282	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
323098007283	ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583
323098007284	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
323098007285	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
323098007286	Ligand binding site; other site
323098007287	Putative Catalytic site; other site
323098007288	DXD motif; other site
323098007289	uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807
323098007290	putative active site [active]
323098007291	YdjC motif; other site
323098007292	Mg binding site [ion binding]; other site
323098007293	putative homodimer interface [polypeptide binding]; other site
323098007294	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
323098007295	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
323098007296	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
323098007297	Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219
323098007298	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
323098007299	oligomerisation interface [polypeptide binding]; other site
323098007300	mobile loop; other site
323098007301	roof hairpin; other site
323098007302	chaperonin GroEL; Reviewed; Region: groEL; PRK12852
323098007303	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
323098007304	ring oligomerisation interface [polypeptide binding]; other site
323098007305	ATP/Mg binding site [chemical binding]; other site
323098007306	stacking interactions; other site
323098007307	hinge regions; other site
323098007308	META domain; Region: META; cl01245
323098007309	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
323098007310	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
323098007311	Cysteine-rich domain; Region: CCG; pfam02754
323098007312	Cysteine-rich domain; Region: CCG; pfam02754
323098007313	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
323098007314	FAD binding domain; Region: FAD_binding_4; pfam01565
323098007315	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
323098007316	FAD binding domain; Region: FAD_binding_4; pfam01565
323098007317	Cytochrome c2 [Energy production and conversion]; Region: COG3474
323098007318	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
323098007319	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
323098007320	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
323098007321	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
323098007322	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
323098007323	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
323098007324	dimer interface [polypeptide binding]; other site
323098007325	motif 1; other site
323098007326	active site
323098007327	motif 2; other site
323098007328	motif 3; other site
323098007329	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
323098007330	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
323098007331	tandem repeat interface [polypeptide binding]; other site
323098007332	oligomer interface [polypeptide binding]; other site
323098007333	active site residues [active]
323098007334	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
323098007335	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
323098007336	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
323098007337	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
323098007338	substrate binding pocket [chemical binding]; other site
323098007339	chain length determination region; other site
323098007340	substrate-Mg2+ binding site; other site
323098007341	catalytic residues [active]
323098007342	aspartate-rich region 1; other site
323098007343	active site lid residues [active]
323098007344	aspartate-rich region 2; other site
323098007345	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
323098007346	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
323098007347	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
323098007348	TPR motif; other site
323098007349	binding surface
323098007350	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
323098007351	binding surface
323098007352	TPR motif; other site
323098007353	TPR repeat; Region: TPR_11; pfam13414
323098007354	TPR repeat; Region: TPR_11; pfam13414
323098007355	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
323098007356	binding surface
323098007357	TPR motif; other site
323098007358	TPR repeat; Region: TPR_11; pfam13414
323098007359	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
323098007360	hydroxyglutarate oxidase; Provisional; Region: PRK11728
323098007361	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
323098007362	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
323098007363	Fe-S cluster binding site [ion binding]; other site
323098007364	active site
323098007365	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
323098007366	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
323098007367	RNA/DNA hybrid binding site [nucleotide binding]; other site
323098007368	active site
323098007369	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
323098007370	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
323098007371	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
323098007372	FeS/SAM binding site; other site
323098007373	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
323098007374	MPT binding site; other site
323098007375	trimer interface [polypeptide binding]; other site
323098007376	Predicted metalloprotease [General function prediction only]; Region: COG2321
323098007377	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
323098007378	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
323098007379	DNA methylase; Region: N6_N4_Mtase; pfam01555
323098007380	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
323098007381	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
323098007382	C-terminal domain interface [polypeptide binding]; other site
323098007383	GSH binding site (G-site) [chemical binding]; other site
323098007384	dimer interface [polypeptide binding]; other site
323098007385	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
323098007386	N-terminal domain interface [polypeptide binding]; other site
323098007387	dimer interface [polypeptide binding]; other site
323098007388	substrate binding pocket (H-site) [chemical binding]; other site
323098007389	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
323098007390	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
323098007391	minor groove reading motif; other site
323098007392	helix-hairpin-helix signature motif; other site
323098007393	active site
323098007394	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
323098007395	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
323098007396	DNA binding and oxoG recognition site [nucleotide binding]
323098007397	Protein of unknown function (DUF721); Region: DUF721; cl02324
323098007398	Thioredoxin; Region: Thioredoxin_4; pfam13462
323098007399	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
323098007400	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
323098007401	AAA domain; Region: AAA_23; pfam13476
323098007402	Walker A/P-loop; other site
323098007403	ATP binding site [chemical binding]; other site
323098007404	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
323098007405	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
323098007406	ABC transporter signature motif; other site
323098007407	Walker B; other site
323098007408	D-loop; other site
323098007409	H-loop/switch region; other site
323098007410	Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847
323098007411	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
323098007412	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
323098007413	Peptidase family M48; Region: Peptidase_M48; cl12018
323098007414	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
323098007415	active site
323098007416	anthranilate synthase; Provisional; Region: PRK13566
323098007417	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
323098007418	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
323098007419	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
323098007420	glutamine binding [chemical binding]; other site
323098007421	catalytic triad [active]
323098007422	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
323098007423	substrate binding site [chemical binding]; other site
323098007424	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
323098007425	cytochrome b; Provisional; Region: CYTB; MTH00156
323098007426	Qi binding site; other site
323098007427	intrachain domain interface; other site
323098007428	interchain domain interface [polypeptide binding]; other site
323098007429	heme bH binding site [chemical binding]; other site
323098007430	heme bL binding site [chemical binding]; other site
323098007431	Qo binding site; other site
323098007432	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
323098007433	interchain domain interface [polypeptide binding]; other site
323098007434	intrachain domain interface; other site
323098007435	Qi binding site; other site
323098007436	Qo binding site; other site
323098007437	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
323098007438	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
323098007439	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
323098007440	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
323098007441	[2Fe-2S] cluster binding site [ion binding]; other site
323098007442	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
323098007443	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
323098007444	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
323098007445	FeS/SAM binding site; other site
323098007446	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
323098007447	active site
323098007448	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
323098007449	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752
323098007450	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
323098007451	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
323098007452	active site
323098007453	NTP binding site [chemical binding]; other site
323098007454	metal binding triad [ion binding]; metal-binding site
323098007455	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
323098007456	putative active site [active]
323098007457	putative CoA binding site [chemical binding]; other site
323098007458	nudix motif; other site
323098007459	metal binding site [ion binding]; metal-binding site
323098007460	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816
323098007461	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
323098007462	MoxR-like ATPases [General function prediction only]; Region: COG0714
323098007463	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323098007464	Walker A motif; other site
323098007465	ATP binding site [chemical binding]; other site
323098007466	Walker B motif; other site
323098007467	arginine finger; other site
323098007468	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
323098007469	Protein of unknown function DUF58; Region: DUF58; pfam01882
323098007470	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
323098007471	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
323098007472	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
323098007473	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
323098007474	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
323098007475	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
323098007476	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
323098007477	Coenzyme A binding pocket [chemical binding]; other site
323098007478	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680
323098007479	nudix motif; other site
323098007480	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
323098007481	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
323098007482	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
323098007483	Protein of unknown function, DUF486; Region: DUF486; cl01236
323098007484	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
323098007485	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
323098007486	catalytic residues [active]
323098007487	dimer interface [polypeptide binding]; other site
323098007488	bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533
323098007489	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
323098007490	putative active site [active]
323098007491	catalytic residue [active]
323098007492	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
323098007493	active site
323098007494	dimer interface [polypeptide binding]; other site
323098007495	SIS_TAL_PGI: Transaldolase (TAL)/ Phosphoglucose isomerase (PGI). This group represents the SIS (Sugar ISomerase) PGI domain, of a multifunctional protein (TAL-PGI ) having both TAL and PGI activities. TAL_PGI contains an N-terminal TAL domain and a...; Region: SIS_TAL_PGI; cd05798
323098007496	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
323098007497	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
323098007498	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
323098007499	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
323098007500	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
323098007501	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
323098007502	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
323098007503	putative active site [active]
323098007504	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
323098007505	AAA domain; Region: AAA_33; pfam13671
323098007506	ATP-binding site [chemical binding]; other site
323098007507	Gluconate-6-phosphate binding site [chemical binding]; other site
323098007508	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
323098007509	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
323098007510	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
323098007511	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
323098007512	metal binding site [ion binding]; metal-binding site
323098007513	active site
323098007514	I-site; other site
323098007515	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
323098007516	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
323098007517	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
323098007518	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
323098007519	Cytochrome c; Region: Cytochrom_C; pfam00034
323098007520	Cytochrome c; Region: Cytochrom_C; pfam00034
323098007521	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
323098007522	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
323098007523	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
323098007524	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
323098007525	TPR motif; other site
323098007526	binding surface
323098007527	Transcriptional regulator; Region: Rrf2; cl17282
323098007528	Rrf2 family protein; Region: rrf2_super; TIGR00738
323098007529	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
323098007530	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
323098007531	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
323098007532	monovalent cation:proton antiporter; Region: 2a6301s02; TIGR00943
323098007533	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
323098007534	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
323098007535	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
323098007536	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
323098007537	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161
323098007538	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671
323098007539	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
323098007540	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
323098007541	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
323098007542	short chain dehydrogenase; Provisional; Region: PRK06701
323098007543	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323098007544	NAD(P) binding site [chemical binding]; other site
323098007545	active site
323098007546	Isochorismatase family; Region: Isochorismatase; pfam00857
323098007547	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
323098007548	catalytic triad [active]
323098007549	conserved cis-peptide bond; other site
323098007550	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
323098007551	dimerization interface [polypeptide binding]; other site
323098007552	metal binding site [ion binding]; metal-binding site
323098007553	Helix-turn-helix domain; Region: HTH_28; pfam13518
323098007554	Winged helix-turn helix; Region: HTH_29; pfam13551
323098007555	Homeodomain-like domain; Region: HTH_32; pfam13565
323098007556	Integrase core domain; Region: rve; pfam00665
323098007557	Integrase core domain; Region: rve_3; pfam13683
323098007558	Transposase; Region: HTH_Tnp_1; pfam01527
323098007559	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323098007560	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
323098007561	FtsX-like permease family; Region: FtsX; pfam02687
323098007562	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
323098007563	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
323098007564	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
323098007565	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
323098007566	Walker A/P-loop; other site
323098007567	ATP binding site [chemical binding]; other site
323098007568	Q-loop/lid; other site
323098007569	ABC transporter signature motif; other site
323098007570	Walker B; other site
323098007571	D-loop; other site
323098007572	H-loop/switch region; other site
323098007573	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
323098007574	Transposase; Region: HTH_Tnp_1; pfam01527
323098007575	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323098007576	Helix-turn-helix domain; Region: HTH_28; pfam13518
323098007577	Winged helix-turn helix; Region: HTH_29; pfam13551
323098007578	Homeodomain-like domain; Region: HTH_32; pfam13565
323098007579	Integrase core domain; Region: rve; pfam00665
323098007580	Integrase core domain; Region: rve_3; pfam13683
323098007581	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
323098007582	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
323098007583	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
323098007584	putative dimer interface [polypeptide binding]; other site
323098007585	N-terminal domain interface [polypeptide binding]; other site
323098007586	putative substrate binding pocket (H-site) [chemical binding]; other site
323098007587	Predicted membrane protein [Function unknown]; Region: COG1238
323098007588	NMT1/THI5 like; Region: NMT1; pfam09084
323098007589	cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657
323098007590	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
323098007591	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
323098007592	Walker A/P-loop; other site
323098007593	ATP binding site [chemical binding]; other site
323098007594	Q-loop/lid; other site
323098007595	ABC transporter signature motif; other site
323098007596	Walker B; other site
323098007597	D-loop; other site
323098007598	H-loop/switch region; other site
323098007599	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
323098007600	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
323098007601	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
323098007602	Ligand Binding Site [chemical binding]; other site
323098007603	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
323098007604	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
323098007605	acyl-activating enzyme (AAE) consensus motif; other site
323098007606	putative AMP binding site [chemical binding]; other site
323098007607	putative active site [active]
323098007608	putative CoA binding site [chemical binding]; other site
323098007609	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
323098007610	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
323098007611	catalytic triad [active]
323098007612	dimer interface [polypeptide binding]; other site
323098007613	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
323098007614	RNA/DNA hybrid binding site [nucleotide binding]; other site
323098007615	active site
323098007616	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
323098007617	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
323098007618	putative active site [active]
323098007619	putative substrate binding site [chemical binding]; other site
323098007620	ATP binding site [chemical binding]; other site
323098007621	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
323098007622	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
323098007623	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820
323098007624	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
323098007625	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
323098007626	intersubunit interface [polypeptide binding]; other site
323098007627	active site
323098007628	zinc binding site [ion binding]; other site
323098007629	Na+ binding site [ion binding]; other site
323098007630	phosphoribulokinase; Provisional; Region: PRK15453
323098007631	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
323098007632	metal binding site [ion binding]; metal-binding site
323098007633	active site
323098007634	Transcriptional regulator [Transcription]; Region: LysR; COG0583
323098007635	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
323098007636	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
323098007637	putative dimerization interface [polypeptide binding]; other site
323098007638	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
323098007639	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
323098007640	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
323098007641	FAD binding domain; Region: FAD_binding_4; pfam01565
323098007642	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
323098007643	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673
323098007644	nudix motif; other site
323098007645	TIGR02301 family protein; Region: TIGR02301
323098007646	dihydroorotase; Validated; Region: PRK09060
323098007647	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
323098007648	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
323098007649	active site
323098007650	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
323098007651	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
323098007652	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
323098007653	Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896
323098007654	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
323098007655	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
323098007656	pyruvate phosphate dikinase; Provisional; Region: PRK09279
323098007657	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
323098007658	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
323098007659	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
323098007660	FtsH Extracellular; Region: FtsH_ext; pfam06480
323098007661	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
323098007662	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323098007663	Walker A motif; other site
323098007664	ATP binding site [chemical binding]; other site
323098007665	Walker B motif; other site
323098007666	arginine finger; other site
323098007667	Peptidase family M41; Region: Peptidase_M41; pfam01434
323098007668	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
323098007669	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
323098007670	Ligand Binding Site [chemical binding]; other site
323098007671	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
323098007672	active site
323098007673	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
323098007674	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
323098007675	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
323098007676	ligand binding site [chemical binding]; other site
323098007677	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
323098007678	PAS fold; Region: PAS_7; pfam12860
323098007679	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
323098007680	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
323098007681	metal binding site [ion binding]; metal-binding site
323098007682	active site
323098007683	I-site; other site
323098007684	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
323098007685	translocation protein TolB; Provisional; Region: tolB; PRK05137
323098007686	TolB amino-terminal domain; Region: TolB_N; pfam04052
323098007687	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
323098007688	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
323098007689	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
323098007690	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
323098007691	TolA protein; Region: tolA_full; TIGR02794
323098007692	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
323098007693	TolR protein; Region: tolR; TIGR02801
323098007694	TolQ protein; Region: tolQ; TIGR02796
323098007695	Protein of unknown function (DUF2852); Region: DUF2852; pfam11014
323098007696	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
323098007697	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
323098007698	WHG domain; Region: WHG; pfam13305
323098007699	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
323098007700	active site
323098007701	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
323098007702	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323098007703	Walker A motif; other site
323098007704	ATP binding site [chemical binding]; other site
323098007705	Walker B motif; other site
323098007706	arginine finger; other site
323098007707	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
323098007708	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
323098007709	RuvA N terminal domain; Region: RuvA_N; pfam01330
323098007710	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
323098007711	active site
323098007712	putative DNA-binding cleft [nucleotide binding]; other site
323098007713	dimer interface [polypeptide binding]; other site
323098007714	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
323098007715	MgtE intracellular N domain; Region: MgtE_N; pfam03448
323098007716	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
323098007717	Divalent cation transporter; Region: MgtE; pfam01769
323098007718	hypothetical protein; Validated; Region: PRK00110
323098007719	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
323098007720	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
323098007721	putative active site [active]
323098007722	metal binding site [ion binding]; metal-binding site
323098007723	homodimer binding site [polypeptide binding]; other site
323098007724	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
323098007725	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
323098007726	Cell division protein ZapA; Region: ZapA; pfam05164
323098007727	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
323098007728	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
323098007729	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
323098007730	TPP-binding site [chemical binding]; other site
323098007731	dimer interface [polypeptide binding]; other site
323098007732	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
323098007733	PYR/PP interface [polypeptide binding]; other site
323098007734	dimer interface [polypeptide binding]; other site
323098007735	TPP binding site [chemical binding]; other site
323098007736	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
323098007737	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
323098007738	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
323098007739	Phosphoglycerate kinase; Region: PGK; pfam00162
323098007740	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
323098007741	substrate binding site [chemical binding]; other site
323098007742	hinge regions; other site
323098007743	ADP binding site [chemical binding]; other site
323098007744	catalytic site [active]
323098007745	Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948
323098007746	active site
323098007747	intersubunit interface [polypeptide binding]; other site
323098007748	catalytic residue [active]
323098007749	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
323098007750	active site
323098007751	pyrophosphate binding site [ion binding]; other site
323098007752	thiamine phosphate binding site [chemical binding]; other site
323098007753	Sel1-like repeats; Region: SEL1; smart00671
323098007754	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
323098007755	Sel1-like repeats; Region: SEL1; smart00671
323098007756	Sel1-like repeats; Region: SEL1; smart00671
323098007757	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
323098007758	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
323098007759	active site
323098007760	dimerization interface [polypeptide binding]; other site
323098007761	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
323098007762	Protein export membrane protein; Region: SecD_SecF; cl14618
323098007763	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
323098007764	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
323098007765	HlyD family secretion protein; Region: HlyD_3; pfam13437
323098007766	hypothetical protein; Validated; Region: PRK09039
323098007767	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
323098007768	ligand binding site [chemical binding]; other site
323098007769	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
323098007770	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
323098007771	Coenzyme A binding pocket [chemical binding]; other site
323098007772	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
323098007773	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
323098007774	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
323098007775	Walker A/P-loop; other site
323098007776	ATP binding site [chemical binding]; other site
323098007777	Q-loop/lid; other site
323098007778	ABC transporter signature motif; other site
323098007779	Walker B; other site
323098007780	D-loop; other site
323098007781	H-loop/switch region; other site
323098007782	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
323098007783	Protein of unknown function (DUF1465); Region: DUF1465; pfam07323
323098007784	Protein of unknown function (DUF1192); Region: DUF1192; pfam06698
323098007785	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
323098007786	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
323098007787	NAD(P) binding site [chemical binding]; other site
323098007788	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
323098007789	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
323098007790	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
323098007791	PAS fold; Region: PAS; pfam00989
323098007792	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323098007793	putative active site [active]
323098007794	heme pocket [chemical binding]; other site
323098007795	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
323098007796	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
323098007797	metal binding site [ion binding]; metal-binding site
323098007798	active site
323098007799	I-site; other site
323098007800	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
323098007801	hypothetical protein; Validated; Region: PRK00228
323098007802	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
323098007803	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
323098007804	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
323098007805	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323098007806	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
323098007807	NAD(P) binding site [chemical binding]; other site
323098007808	active site
323098007809	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
323098007810	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
323098007811	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
323098007812	Walker A/P-loop; other site
323098007813	ATP binding site [chemical binding]; other site
323098007814	Q-loop/lid; other site
323098007815	ABC transporter signature motif; other site
323098007816	Walker B; other site
323098007817	D-loop; other site
323098007818	H-loop/switch region; other site
323098007819	TOBE-like domain; Region: TOBE_3; pfam12857
323098007820	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
323098007821	sulfate transport protein; Provisional; Region: cysT; CHL00187
323098007822	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
323098007823	dimer interface [polypeptide binding]; other site
323098007824	conserved gate region; other site
323098007825	putative PBP binding loops; other site
323098007826	ABC-ATPase subunit interface; other site
323098007827	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
323098007828	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
323098007829	dimer interface [polypeptide binding]; other site
323098007830	conserved gate region; other site
323098007831	putative PBP binding loops; other site
323098007832	ABC-ATPase subunit interface; other site
323098007833	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
323098007834	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
323098007835	substrate binding pocket [chemical binding]; other site
323098007836	membrane-bound complex binding site; other site
323098007837	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
323098007838	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
323098007839	Active Sites [active]
323098007840	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
323098007841	Putative NAD(P)-binding; Region: NAD_binding_7; cl17660
323098007842	Putative NAD(P)-binding; Region: NAD_binding_7; cl17660
323098007843	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
323098007844	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
323098007845	active site
323098007846	SAM binding site [chemical binding]; other site
323098007847	homodimer interface [polypeptide binding]; other site
323098007848	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
323098007849	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
323098007850	Active Sites [active]
323098007851	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
323098007852	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
323098007853	G1 box; other site
323098007854	putative GEF interaction site [polypeptide binding]; other site
323098007855	GTP/Mg2+ binding site [chemical binding]; other site
323098007856	Switch I region; other site
323098007857	G2 box; other site
323098007858	CysD dimerization site [polypeptide binding]; other site
323098007859	G3 box; other site
323098007860	Switch II region; other site
323098007861	G4 box; other site
323098007862	G5 box; other site
323098007863	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
323098007864	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
323098007865	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
323098007866	ligand-binding site [chemical binding]; other site
323098007867	malate synthase G; Provisional; Region: PRK02999
323098007868	active site
323098007869	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
323098007870	two-component response regulator; Provisional; Region: PRK09191
323098007871	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323098007872	active site
323098007873	phosphorylation site [posttranslational modification]
323098007874	intermolecular recognition site; other site
323098007875	dimerization interface [polypeptide binding]; other site
323098007876	RNA polymerase sigma factor; Provisional; Region: PRK12540
323098007877	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
323098007878	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
323098007879	DNA binding residues [nucleotide binding]
323098007880	This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079
323098007881	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
323098007882	HWE histidine kinase; Region: HWE_HK; pfam07536
323098007883	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
323098007884	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
323098007885	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
323098007886	FeS/SAM binding site; other site
323098007887	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
323098007888	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
323098007889	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
323098007890	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
323098007891	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
323098007892	signal recognition particle protein; Provisional; Region: PRK10867
323098007893	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
323098007894	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
323098007895	P loop; other site
323098007896	GTP binding site [chemical binding]; other site
323098007897	Signal peptide binding domain; Region: SRP_SPB; pfam02978
323098007898	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
323098007899	RimM N-terminal domain; Region: RimM; pfam01782
323098007900	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828
323098007901	PRC-barrel domain; Region: PRC; pfam05239
323098007902	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
323098007903	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
323098007904	DNA primase (bacterial type) [DNA replication, recombination, and repair]; Region: DnaG; COG0358
323098007905	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
323098007906	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
323098007907	substrate binding site [chemical binding]; other site
323098007908	ligand binding site [chemical binding]; other site
323098007909	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
323098007910	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
323098007911	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
323098007912	substrate binding site [chemical binding]; other site
323098007913	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
323098007914	active site clefts [active]
323098007915	zinc binding site [ion binding]; other site
323098007916	dimer interface [polypeptide binding]; other site
323098007917	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
323098007918	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
323098007919	tartrate dehydrogenase; Region: TTC; TIGR02089
323098007920	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
323098007921	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
323098007922	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
323098007923	E-class dimer interface [polypeptide binding]; other site
323098007924	P-class dimer interface [polypeptide binding]; other site
323098007925	active site
323098007926	Cu2+ binding site [ion binding]; other site
323098007927	Zn2+ binding site [ion binding]; other site
323098007928	malonyl-CoA synthase; Validated; Region: PRK07514
323098007929	Malonyl-CoA synthetase (MCS); Region: MCS; cd05941
323098007930	acyl-activating enzyme (AAE) consensus motif; other site
323098007931	active site
323098007932	AMP binding site [chemical binding]; other site
323098007933	CoA binding site [chemical binding]; other site
323098007934	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
323098007935	Iron-sulfur protein interface; other site
323098007936	proximal quinone binding site [chemical binding]; other site
323098007937	SdhD (CybS) interface [polypeptide binding]; other site
323098007938	proximal heme binding site [chemical binding]; other site
323098007939	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
323098007940	putative SdhC subunit interface [polypeptide binding]; other site
323098007941	putative proximal heme binding site [chemical binding]; other site
323098007942	putative Iron-sulfur protein interface [polypeptide binding]; other site
323098007943	putative proximal quinone binding site; other site
323098007944	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
323098007945	L-aspartate oxidase; Provisional; Region: PRK06175
323098007946	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
323098007947	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
323098007948	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
323098007949	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
323098007950	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
323098007951	ligand binding site [chemical binding]; other site
323098007952	argininosuccinate synthase; Provisional; Region: PRK13820
323098007953	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
323098007954	ANP binding site [chemical binding]; other site
323098007955	Substrate Binding Site II [chemical binding]; other site
323098007956	Substrate Binding Site I [chemical binding]; other site
323098007957	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
323098007958	active site
323098007959	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
323098007960	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
323098007961	FeS/SAM binding site; other site
323098007962	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
323098007963	Uncharacterized conserved protein [Function unknown]; Region: COG3339
323098007964	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914
323098007965	aromatic arch; other site
323098007966	DCoH dimer interaction site [polypeptide binding]; other site
323098007967	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
323098007968	DCoH tetramer interaction site [polypeptide binding]; other site
323098007969	substrate binding site [chemical binding]; other site
323098007970	Ferredoxin [Energy production and conversion]; Region: COG1146
323098007971	4Fe-4S binding domain; Region: Fer4; pfam00037
323098007972	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
323098007973	Uncharacterized conserved protein [Function unknown]; Region: COG3189
323098007974	heat shock protein 90; Provisional; Region: PRK05218
323098007975	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323098007976	ATP binding site [chemical binding]; other site
323098007977	Mg2+ binding site [ion binding]; other site
323098007978	G-X-G motif; other site
323098007979	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
323098007980	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
323098007981	Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029
323098007982	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
323098007983	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
323098007984	ApbE family; Region: ApbE; pfam02424
323098007985	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
323098007986	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
323098007987	FMN binding site [chemical binding]; other site
323098007988	active site
323098007989	catalytic residues [active]
323098007990	substrate binding site [chemical binding]; other site
323098007991	Winged helix-turn helix; Region: HTH_29; pfam13551
323098007992	Integrase core domain; Region: rve; pfam00665
323098007993	Integrase core domain; Region: rve_3; pfam13683
323098007994	Helix-turn-helix domain; Region: HTH_28; pfam13518
323098007995	Winged helix-turn helix; Region: HTH_29; pfam13551
323098007996	Homeodomain-like domain; Region: HTH_32; pfam13565
323098007997	Integrase core domain; Region: rve; pfam00665
323098007998	Integrase core domain; Region: rve_3; pfam13683
323098007999	Transposase; Region: HTH_Tnp_1; pfam01527
323098008000	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323098008001	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323098008002	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323098008003	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
323098008004	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323098008005	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323098008006	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
323098008007	Uncharacterized conserved protein (DUF2190); Region: DUF2190; pfam09956
323098008008	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
323098008009	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
323098008010	Phage protein Gp37/Gp68; Region: Gp37_Gp68; pfam07505
323098008011	Integrase core domain; Region: rve; pfam00665
323098008012	Integrase core domain; Region: rve_3; pfam13683
323098008013	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
323098008014	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
323098008015	catalytic residues [active]
323098008016	catalytic nucleophile [active]
323098008017	Recombinase; Region: Recombinase; pfam07508
323098008018	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
323098008019	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
323098008020	Autotransporter beta-domain; Region: Autotransporter; smart00869
323098008021	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
323098008022	Caspase domain; Region: Peptidase_C14; pfam00656
323098008023	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
323098008024	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323098008025	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323098008026	Winged helix-turn helix; Region: HTH_29; pfam13551
323098008027	Homeodomain-like domain; Region: HTH_23; cl17451
323098008028	Homeodomain-like domain; Region: HTH_32; pfam13565
323098008029	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323098008030	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323098008031	Integrase core domain; Region: rve; pfam00665
323098008032	Integrase core domain; Region: rve_3; pfam13683
323098008033	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
323098008034	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
323098008035	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
323098008036	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
323098008037	homodimer interface [polypeptide binding]; other site
323098008038	active site
323098008039	TDP-binding site; other site
323098008040	acceptor substrate-binding pocket; other site
323098008041	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
323098008042	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
323098008043	Protein of unknown function (DUF1778); Region: DUF1778; pfam08681
323098008044	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
323098008045	Coenzyme A binding pocket [chemical binding]; other site
323098008046	conjugal transfer coupling protein TraG; Provisional; Region: PRK13876
323098008047	PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734
323098008048	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
323098008049	generic binding surface I; other site
323098008050	generic binding surface II; other site
323098008051	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323098008052	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
323098008053	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323098008054	Transposase; Region: HTH_Tnp_1; pfam01527
323098008055	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323098008056	Helix-turn-helix domain; Region: HTH_28; pfam13518
323098008057	putative transposase OrfB; Reviewed; Region: PHA02517
323098008058	Homeodomain-like domain; Region: HTH_32; pfam13565
323098008059	Integrase core domain; Region: rve; pfam00665
323098008060	Integrase core domain; Region: rve_3; pfam13683
323098008061	Helix-turn-helix domain; Region: HTH_28; pfam13518
323098008062	Winged helix-turn helix; Region: HTH_29; pfam13551
323098008063	Homeodomain-like domain; Region: HTH_32; pfam13565
323098008064	Integrase core domain; Region: rve; pfam00665
323098008065	Integrase core domain; Region: rve_3; pfam13683
323098008066	Transposase; Region: HTH_Tnp_1; pfam01527
323098008067	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323098008068	HipA N-terminal domain; Region: Couple_hipA; cl11853
323098008069	HipA-like N-terminal domain; Region: HipA_N; pfam07805
323098008070	HipA-like C-terminal domain; Region: HipA_C; pfam07804
323098008071	Helix-turn-helix domain; Region: HTH_31; pfam13560
323098008072	Prokaryotic E2 family A; Region: Prok-E2_A; pfam14457
323098008073	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
323098008074	ATP binding site [chemical binding]; other site
323098008075	Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464
323098008076	ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187
323098008077	Helix-turn-helix domain; Region: HTH_28; pfam13518
323098008078	putative transposase OrfB; Reviewed; Region: PHA02517
323098008079	Homeodomain-like domain; Region: HTH_32; pfam13565
323098008080	Integrase core domain; Region: rve; pfam00665
323098008081	Integrase core domain; Region: rve_3; pfam13683
323098008082	Transposase; Region: HTH_Tnp_1; pfam01527
323098008083	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323098008084	Secretin and TonB N terminus short domain; Region: STN; smart00965
323098008085	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
323098008086	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
323098008087	N-terminal plug; other site
323098008088	ligand-binding site [chemical binding]; other site
323098008089	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
323098008090	FecR protein; Region: FecR; pfam04773
323098008091	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
323098008092	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
323098008093	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
323098008094	DNA binding residues [nucleotide binding]
323098008095	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
323098008096	MarR family; Region: MarR_2; pfam12802
323098008097	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
323098008098	dimer interface [polypeptide binding]; other site
323098008099	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
323098008100	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
323098008101	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
323098008102	dimer interface [polypeptide binding]; other site
323098008103	putative radical transfer pathway; other site
323098008104	diiron center [ion binding]; other site
323098008105	tyrosyl radical; other site
323098008106	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
323098008107	ATP cone domain; Region: ATP-cone; pfam03477
323098008108	ATP cone domain; Region: ATP-cone; pfam03477
323098008109	Class I ribonucleotide reductase; Region: RNR_I; cd01679
323098008110	active site
323098008111	dimer interface [polypeptide binding]; other site
323098008112	catalytic residues [active]
323098008113	effector binding site; other site
323098008114	R2 peptide binding site; other site
323098008115	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
323098008116	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
323098008117	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
323098008118	THF binding site; other site
323098008119	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
323098008120	substrate binding site [chemical binding]; other site
323098008121	THF binding site; other site
323098008122	zinc-binding site [ion binding]; other site
323098008123	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
323098008124	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
323098008125	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
323098008126	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
323098008127	substrate binding pocket [chemical binding]; other site
323098008128	membrane-bound complex binding site; other site
323098008129	hinge residues; other site
323098008130	Protein of unknown function (DUF938); Region: DUF938; pfam06080
323098008131	DsrE/DsrF-like family; Region: DrsE; pfam02635
323098008132	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
323098008133	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
323098008134	active site residue [active]
323098008135	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
323098008136	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
323098008137	metal binding site [ion binding]; metal-binding site
323098008138	active site
323098008139	I-site; other site
323098008140	PRC-barrel domain; Region: PRC; pfam05239
323098008141	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
323098008142	Winged helix-turn helix; Region: HTH_29; pfam13551
323098008143	Integrase core domain; Region: rve; pfam00665
323098008144	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
323098008145	Integrase core domain; Region: rve_3; pfam13683
323098008146	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
323098008147	dimerization interface [polypeptide binding]; other site
323098008148	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
323098008149	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
323098008150	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
323098008151	N-terminal plug; other site
323098008152	ligand-binding site [chemical binding]; other site
323098008153	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698
323098008154	BNR repeat-like domain; Region: BNR_2; pfam13088
323098008155	Asp-box motif; other site
323098008156	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698
323098008157	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
323098008158	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
323098008159	catalytic residues [active]
323098008160	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215
323098008161	Protein of unknown function (DUF1007); Region: DUF1007; pfam06226
323098008162	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
323098008163	dimerization interface [polypeptide binding]; other site
323098008164	putative DNA binding site [nucleotide binding]; other site
323098008165	putative Zn2+ binding site [ion binding]; other site
323098008166	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
323098008167	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
323098008168	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
323098008169	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
323098008170	HlyD family secretion protein; Region: HlyD_3; pfam13437
323098008171	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
323098008172	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323098008173	active site
323098008174	phosphorylation site [posttranslational modification]
323098008175	intermolecular recognition site; other site
323098008176	dimerization interface [polypeptide binding]; other site
323098008177	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
323098008178	DNA binding site [nucleotide binding]
323098008179	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
323098008180	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
323098008181	dimerization interface [polypeptide binding]; other site
323098008182	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323098008183	dimer interface [polypeptide binding]; other site
323098008184	phosphorylation site [posttranslational modification]
323098008185	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323098008186	ATP binding site [chemical binding]; other site
323098008187	Mg2+ binding site [ion binding]; other site
323098008188	G-X-G motif; other site
323098008189	Predicted membrane protein [Function unknown]; Region: COG4244
323098008190	Winged helix-turn helix; Region: HTH_29; pfam13551
323098008191	Integrase core domain; Region: rve; pfam00665
323098008192	Integrase core domain; Region: rve_3; pfam13683
323098008193	Winged helix-turn helix; Region: HTH_29; pfam13551
323098008194	Integrase core domain; Region: rve; pfam00665
323098008195	Integrase core domain; Region: rve_3; pfam13683
323098008196	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323098008197	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
323098008198	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323098008199	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323098008200	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323098008201	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323098008202	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323098008203	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
323098008204	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
323098008205	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323098008206	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
323098008207	non-specific DNA binding site [nucleotide binding]; other site
323098008208	salt bridge; other site
323098008209	sequence-specific DNA binding site [nucleotide binding]; other site
323098008210	probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880
323098008211	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
323098008212	Walker A motif; other site
323098008213	ATP binding site [chemical binding]; other site
323098008214	Walker B motif; other site
323098008215	arginine finger; other site
323098008216	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
323098008217	multimerization interface [polypeptide binding]; other site
323098008218	ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208
323098008219	Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212
323098008220	homodimer interface [polypeptide binding]; other site
323098008221	active site
323098008222	heterodimer interface [polypeptide binding]; other site
323098008223	catalytic residue [active]
323098008224	metal binding site [ion binding]; metal-binding site
323098008225	Transcriptional regulator [Transcription]; Region: LysR; COG0583
323098008226	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
323098008227	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
323098008228	putative dimerization interface [polypeptide binding]; other site
323098008229	Nitrogen regulatory protein P-II; Region: P-II; smart00938
323098008230	Nitrogen regulatory protein P-II; Region: P-II; cl00412
323098008231	Carboxysome Shell Carbonic Anhydrase; Region: CsoSCA; pfam08936
323098008232	ParB-like nuclease domain; Region: ParBc; pfam02195
323098008233	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
323098008234	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
323098008235	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
323098008236	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
323098008237	protein binding site [polypeptide binding]; other site
323098008238	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
323098008239	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
323098008240	putative dimer interface [polypeptide binding]; other site
323098008241	alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175
323098008242	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
323098008243	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
323098008244	putative dimer interface [polypeptide binding]; other site
323098008245	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
323098008246	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
323098008247	putative dimer interface [polypeptide binding]; other site
323098008248	Helix-turn-helix domain; Region: HTH_28; pfam13518
323098008249	putative transposase OrfB; Reviewed; Region: PHA02517
323098008250	Homeodomain-like domain; Region: HTH_32; pfam13565
323098008251	Integrase core domain; Region: rve; pfam00665
323098008252	Integrase core domain; Region: rve_3; pfam13683
323098008253	Transposase; Region: HTH_Tnp_1; pfam01527
323098008254	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323098008255	Protein of unknown function (DUF3489); Region: DUF3489; pfam11994
323098008256	Protein of unknown function (DUF2924); Region: DUF2924; pfam11149
323098008257	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
323098008258	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
323098008259	catalytic residues [active]
323098008260	catalytic nucleophile [active]
323098008261	Presynaptic Site I dimer interface [polypeptide binding]; other site
323098008262	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
323098008263	Synaptic Flat tetramer interface [polypeptide binding]; other site
323098008264	Synaptic Site I dimer interface [polypeptide binding]; other site
323098008265	DNA binding site [nucleotide binding]
323098008266	Recombinase; Region: Recombinase; pfam07508
323098008267	Response regulator receiver domain; Region: Response_reg; pfam00072
323098008268	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
323098008269	active site
323098008270	phosphorylation site [posttranslational modification]
323098008271	intermolecular recognition site; other site
323098008272	dimerization interface [polypeptide binding]; other site
323098008273	N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741
323098008274	Winged helix-turn helix; Region: HTH_29; pfam13551
323098008275	Homeodomain-like domain; Region: HTH_23; cl17451
323098008276	Homeodomain-like domain; Region: HTH_32; pfam13565
323098008277	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323098008278	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323098008279	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
323098008280	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
323098008281	active site
323098008282	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
323098008283	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
323098008284	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
323098008285	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
323098008286	putative dimer interface [polypeptide binding]; other site
323098008287	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
323098008288	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
323098008289	active site
323098008290	dimer interface [polypeptide binding]; other site
323098008291	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
323098008292	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
323098008293	active site
323098008294	FMN binding site [chemical binding]; other site
323098008295	substrate binding site [chemical binding]; other site
323098008296	3Fe-4S cluster binding site [ion binding]; other site
323098008297	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
323098008298	domain interface; other site
323098008299	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
323098008300	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
323098008301	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
323098008302	active site
323098008303	oxyanion hole [active]
323098008304	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
323098008305	catalytic triad [active]
323098008306	Transglycosylase SLT domain; Region: SLT_2; pfam13406
323098008307	murein hydrolase B; Provisional; Region: PRK10760; cl17906
323098008308	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
323098008309	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
323098008310	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
323098008311	active site
323098008312	tetramer interface; other site
323098008313	methionine sulfoxide reductase B; Provisional; Region: PRK00222
323098008314	SelR domain; Region: SelR; pfam01641
323098008315	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
323098008316	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
323098008317	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
323098008318	GDP-binding site [chemical binding]; other site
323098008319	ACT binding site; other site
323098008320	IMP binding site; other site
323098008321	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
323098008322	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
323098008323	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
323098008324	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
323098008325	ligand binding site [chemical binding]; other site
323098008326	NAD binding site [chemical binding]; other site
323098008327	dimerization interface [polypeptide binding]; other site
323098008328	catalytic site [active]
323098008329	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
323098008330	putative L-serine binding site [chemical binding]; other site
323098008331	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
323098008332	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
323098008333	catalytic residue [active]
323098008334	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
323098008335	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
323098008336	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323098008337	Major Facilitator Superfamily; Region: MFS_1; pfam07690
323098008338	putative substrate translocation pore; other site
323098008339	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
323098008340	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
323098008341	active site
323098008342	substrate binding site [chemical binding]; other site
323098008343	metal binding site [ion binding]; metal-binding site
323098008344	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
323098008345	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
323098008346	G1 box; other site
323098008347	GTP/Mg2+ binding site [chemical binding]; other site
323098008348	Switch I region; other site
323098008349	G2 box; other site
323098008350	G3 box; other site
323098008351	Switch II region; other site
323098008352	G4 box; other site
323098008353	G5 box; other site
323098008354	Nucleoside recognition; Region: Gate; pfam07670
323098008355	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
323098008356	Nucleoside recognition; Region: Gate; pfam07670
323098008357	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
323098008358	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
323098008359	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
323098008360	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
323098008361	shikimate binding site; other site
323098008362	NAD(P) binding site [chemical binding]; other site
323098008363	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
323098008364	elongation factor G; Reviewed; Region: PRK12740
323098008365	G1 box; other site
323098008366	putative GEF interaction site [polypeptide binding]; other site
323098008367	GTP/Mg2+ binding site [chemical binding]; other site
323098008368	Switch I region; other site
323098008369	G2 box; other site
323098008370	G3 box; other site
323098008371	Switch II region; other site
323098008372	G4 box; other site
323098008373	G5 box; other site
323098008374	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
323098008375	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
323098008376	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
323098008377	Protein of unknown function (DUF992); Region: DUF992; pfam06186
323098008378	aspartate aminotransferase; Provisional; Region: PRK05764
323098008379	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
323098008380	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323098008381	homodimer interface [polypeptide binding]; other site
323098008382	catalytic residue [active]
323098008383	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
323098008384	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
323098008385	putative C-terminal domain interface [polypeptide binding]; other site
323098008386	putative GSH binding site (G-site) [chemical binding]; other site
323098008387	putative dimer interface [polypeptide binding]; other site
323098008388	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
323098008389	N-terminal domain interface [polypeptide binding]; other site
323098008390	dimer interface [polypeptide binding]; other site
323098008391	substrate binding pocket (H-site) [chemical binding]; other site
323098008392	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
323098008393	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
323098008394	isocitrate lyase; Provisional; Region: PRK15063
323098008395	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
323098008396	tetramer interface [polypeptide binding]; other site
323098008397	active site
323098008398	Mg2+/Mn2+ binding site [ion binding]; other site
323098008399	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
323098008400	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
323098008401	non-specific DNA binding site [nucleotide binding]; other site
323098008402	salt bridge; other site
323098008403	sequence-specific DNA binding site [nucleotide binding]; other site
323098008404	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
323098008405	Domain of unknown function (DUF955); Region: DUF955; pfam06114
323098008406	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
323098008407	Cytochrome c; Region: Cytochrom_C; pfam00034
323098008408	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
323098008409	Moco binding site; other site
323098008410	metal coordination site [ion binding]; other site
323098008411	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
323098008412	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
323098008413	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
323098008414	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
323098008415	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
323098008416	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
323098008417	substrate binding site [chemical binding]; other site
323098008418	oxyanion hole (OAH) forming residues; other site
323098008419	trimer interface [polypeptide binding]; other site
323098008420	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
323098008421	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
323098008422	acetyl-CoA acetyltransferase; Provisional; Region: PRK08170
323098008423	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
323098008424	dimer interface [polypeptide binding]; other site
323098008425	active site
323098008426	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
323098008427	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
323098008428	active site
323098008429	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
323098008430	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
323098008431	dimerization interface [polypeptide binding]; other site
323098008432	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
323098008433	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
323098008434	dimer interface [polypeptide binding]; other site
323098008435	putative CheW interface [polypeptide binding]; other site
323098008436	CsbD-like; Region: CsbD; pfam05532
323098008437	rhodanese superfamily protein; Provisional; Region: PRK05320
323098008438	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
323098008439	active site residue [active]
323098008440	SlyX; Region: SlyX; pfam04102
323098008441	Protein of unknown function (DUF3422); Region: DUF3422; pfam11902
323098008442	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
323098008443	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
323098008444	FMN binding site [chemical binding]; other site
323098008445	substrate binding site [chemical binding]; other site
323098008446	putative catalytic residue [active]
323098008447	Protein of unknown function (DUF2478); Region: DUF2478; pfam10649
323098008448	AAA ATPase domain; Region: AAA_16; pfam13191
323098008449	AAA domain; Region: AAA_22; pfam13401
323098008450	Tetratricopeptide repeat; Region: TPR_12; pfam13424
323098008451	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
323098008452	TPR motif; other site
323098008453	binding surface
323098008454	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
323098008455	binding surface
323098008456	TPR motif; other site
323098008457	Tetratricopeptide repeat; Region: TPR_12; pfam13424
323098008458	Tetratricopeptide repeat; Region: TPR_12; pfam13424
323098008459	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
323098008460	TPR motif; other site
323098008461	binding surface
323098008462	Tetratricopeptide repeat; Region: TPR_12; pfam13424
323098008463	Tetratricopeptide repeat; Region: TPR_12; pfam13424
323098008464	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
323098008465	binding surface
323098008466	TPR motif; other site
323098008467	Tetratricopeptide repeat; Region: TPR_12; pfam13424
323098008468	Tetratricopeptide repeat; Region: TPR_12; pfam13424
323098008469	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
323098008470	Winged helix-turn helix; Region: HTH_29; pfam13551
323098008471	Homeodomain-like domain; Region: HTH_23; cl17451
323098008472	Homeodomain-like domain; Region: HTH_32; pfam13565
323098008473	DDE superfamily endonuclease; Region: DDE_3; pfam13358
323098008474	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
323098008475	Predicted transcriptional regulators [Transcription]; Region: COG1695
323098008476	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
323098008477	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
323098008478	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323098008479	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
323098008480	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323098008481	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
323098008482	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
323098008483	active site
323098008484	metal binding site [ion binding]; metal-binding site
323098008485	hypothetical protein; Validated; Region: PRK07586
323098008486	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
323098008487	PYR/PP interface [polypeptide binding]; other site
323098008488	dimer interface [polypeptide binding]; other site
323098008489	TPP binding site [chemical binding]; other site
323098008490	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
323098008491	TPP-binding site [chemical binding]; other site
323098008492	dimer interface [polypeptide binding]; other site
323098008493	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
323098008494	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
323098008495	isovaleryl-CoA dehydrogenase; Region: PLN02519
323098008496	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
323098008497	substrate binding site [chemical binding]; other site
323098008498	FAD binding site [chemical binding]; other site
323098008499	catalytic base [active]
323098008500	YcjX-like family, DUF463; Region: DUF463; pfam04317
323098008501	Domain of unknown function (DUF697); Region: DUF697; cl12064
323098008502	hypothetical protein; Provisional; Region: PRK05415
323098008503	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
323098008504	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
323098008505	sulfite oxidase; Provisional; Region: PLN00177
323098008506	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
323098008507	Moco binding site; other site
323098008508	metal coordination site [ion binding]; other site
323098008509	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
323098008510	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
323098008511	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
323098008512	active site
323098008513	homotetramer interface [polypeptide binding]; other site
323098008514	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
323098008515	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
323098008516	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
323098008517	benzoate transport; Region: 2A0115; TIGR00895
323098008518	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323098008519	putative substrate translocation pore; other site
323098008520	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323098008521	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
323098008522	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
323098008523	ligand binding site [chemical binding]; other site
323098008524	Caspase domain; Region: Peptidase_C14; pfam00656
323098008525	TPR repeat; Region: TPR_11; pfam13414
323098008526	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
323098008527	binding surface
323098008528	TPR motif; other site
323098008529	TPR repeat; Region: TPR_11; pfam13414
323098008530	HlyD family secretion protein; Region: HlyD_3; pfam13437
323098008531	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
323098008532	Protein export membrane protein; Region: SecD_SecF; cl14618
323098008533	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
323098008534	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
323098008535	ligand binding site [chemical binding]; other site
323098008536	flexible hinge region; other site
323098008537	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
323098008538	AsmA family; Region: AsmA; pfam05170
323098008539	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
323098008540	PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025
323098008541	Caspase domain; Region: Peptidase_C14; pfam00656
323098008542	substrate pocket [chemical binding]; other site
323098008543	active site
323098008544	dimer interface [polypeptide binding]; other site
323098008545	proteolytic cleavage site; other site
323098008546	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323098008547	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
323098008548	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323098008549	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
323098008550	HlyD family secretion protein; Region: HlyD_3; pfam13437
323098008551	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
323098008552	dimerization interface [polypeptide binding]; other site
323098008553	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
323098008554	GAF domain; Region: GAF; pfam01590
323098008555	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
323098008556	cyclase homology domain; Region: CHD; cd07302
323098008557	nucleotidyl binding site; other site
323098008558	metal binding site [ion binding]; metal-binding site
323098008559	dimer interface [polypeptide binding]; other site
323098008560	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
323098008561	non-specific DNA binding site [nucleotide binding]; other site
323098008562	salt bridge; other site
323098008563	sequence-specific DNA binding site [nucleotide binding]; other site
323098008564	Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990
323098008565	Secretin and TonB N terminus short domain; Region: STN; smart00965
323098008566	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
323098008567	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
323098008568	N-terminal plug; other site
323098008569	ligand-binding site [chemical binding]; other site
323098008570	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
323098008571	FecR protein; Region: FecR; pfam04773
323098008572	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
323098008573	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
323098008574	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
323098008575	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
323098008576	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
323098008577	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
323098008578	ABC-ATPase subunit  interface; other site
323098008579	dimer interface [polypeptide binding]; other site
323098008580	putative PBP binding regions; other site
323098008581	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
323098008582	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
323098008583	Walker A/P-loop; other site
323098008584	ATP binding site [chemical binding]; other site
323098008585	Q-loop/lid; other site
323098008586	ABC transporter signature motif; other site
323098008587	Walker B; other site
323098008588	D-loop; other site
323098008589	H-loop/switch region; other site
323098008590	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cd00636
323098008591	intersubunit interface [polypeptide binding]; other site
323098008592	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
323098008593	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
323098008594	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
323098008595	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
323098008596	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323098008597	Major Facilitator Superfamily; Region: MFS_1; pfam07690
323098008598	putative substrate translocation pore; other site
323098008599	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
323098008600	DNA-binding site [nucleotide binding]; DNA binding site
323098008601	RNA-binding motif; other site
323098008602	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904
323098008603	Proline dehydrogenase; Region: Pro_dh; pfam01619
323098008604	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
323098008605	Glutamate binding site [chemical binding]; other site
323098008606	NAD binding site [chemical binding]; other site
323098008607	catalytic residues [active]
323098008608	RNA polymerase sigma factor; Provisional; Region: PRK12515
323098008609	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
323098008610	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
323098008611	DNA binding residues [nucleotide binding]
323098008612	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
323098008613	Domain of unknown function (DUF3369); Region: DUF3369; pfam11849
323098008614	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
323098008615	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
323098008616	dimer interface [polypeptide binding]; other site
323098008617	phosphorylation site [posttranslational modification]
323098008618	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323098008619	ATP binding site [chemical binding]; other site
323098008620	Mg2+ binding site [ion binding]; other site
323098008621	G-X-G motif; other site
323098008622	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394
323098008623	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
323098008624	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
323098008625	putative acyltransferase; Provisional; Region: PRK05790
323098008626	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
323098008627	dimer interface [polypeptide binding]; other site
323098008628	active site
323098008629	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
323098008630	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
323098008631	NAD(P) binding site [chemical binding]; other site
323098008632	homotetramer interface [polypeptide binding]; other site
323098008633	homodimer interface [polypeptide binding]; other site
323098008634	active site
323098008635	aromatic amino acid exporter; Provisional; Region: PRK11689
323098008636	EamA-like transporter family; Region: EamA; pfam00892
323098008637	muropeptide transporter; Validated; Region: ampG; cl17669
323098008638	muropeptide transporter; Reviewed; Region: ampG; PRK11902
323098008639	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
323098008640	active site
323098008641	catalytic residues [active]
323098008642	metal binding site [ion binding]; metal-binding site
323098008643	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
323098008644	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
323098008645	putative active site [active]
323098008646	substrate binding site [chemical binding]; other site
323098008647	putative cosubstrate binding site; other site
323098008648	catalytic site [active]
323098008649	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
323098008650	substrate binding site [chemical binding]; other site
323098008651	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
323098008652	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
323098008653	dimerization interface 3.5A [polypeptide binding]; other site
323098008654	active site
323098008655	nucleosidase; Provisional; Region: PRK05634
323098008656	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
323098008657	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
323098008658	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
323098008659	metal binding site [ion binding]; metal-binding site
323098008660	dimer interface [polypeptide binding]; other site
323098008661	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
323098008662	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
323098008663	trimer interface [polypeptide binding]; other site
323098008664	active site
323098008665	substrate binding site [chemical binding]; other site
323098008666	CoA binding site [chemical binding]; other site
323098008667	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
323098008668	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
323098008669	motif II; other site
323098008670	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
323098008671	feedback inhibition sensing region; other site
323098008672	homohexameric interface [polypeptide binding]; other site
323098008673	nucleotide binding site [chemical binding]; other site
323098008674	N-acetyl-L-glutamate binding site [chemical binding]; other site
323098008675	Protein of unknown function (DUF423); Region: DUF423; cl01008
323098008676	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
323098008677	G1 box; other site
323098008678	GTP/Mg2+ binding site [chemical binding]; other site
323098008679	Switch I region; other site
323098008680	G2 box; other site
323098008681	G3 box; other site
323098008682	Switch II region; other site
323098008683	G4 box; other site
323098008684	G5 box; other site
323098008685	membrane protein insertase; Provisional; Region: PRK01318
323098008686	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
323098008687	Ribonuclease P; Region: Ribonuclease_P; cl00457
323098008688	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
323098008689	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
323098008690	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323098008691	ATP binding site [chemical binding]; other site
323098008692	Mg2+ binding site [ion binding]; other site
323098008693	G-X-G motif; other site
323098008694	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
323098008695	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
323098008696	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
323098008697	DNA binding residues [nucleotide binding]
323098008698	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
323098008699	FecR protein; Region: FecR; pfam04773
323098008700	Methyltransferase domain; Region: Methyltransf_26; pfam13659
323098008701	S-adenosylmethionine binding site [chemical binding]; other site
323098008702	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
323098008703	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
323098008704	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
323098008705	putative active site [active]
323098008706	Helix-turn-helix domain; Region: HTH_28; pfam13518
323098008707	Winged helix-turn helix; Region: HTH_29; pfam13551
323098008708	Homeodomain-like domain; Region: HTH_32; pfam13565
323098008709	Integrase core domain; Region: rve; pfam00665
323098008710	Integrase core domain; Region: rve_3; pfam13683
323098008711	Transposase; Region: HTH_Tnp_1; pfam01527
323098008712	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323098008713	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
323098008714	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
323098008715	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
323098008716	putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606
323098008717	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
323098008718	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
323098008719	Helix-turn-helix domain; Region: HTH_28; pfam13518
323098008720	putative transposase OrfB; Reviewed; Region: PHA02517
323098008721	Homeodomain-like domain; Region: HTH_32; pfam13565
323098008722	Integrase core domain; Region: rve; pfam00665
323098008723	Integrase core domain; Region: rve_3; pfam13683
323098008724	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
323098008725	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
323098008726	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
323098008727	trimer interface [polypeptide binding]; other site
323098008728	active site
323098008729	UDP-GlcNAc binding site [chemical binding]; other site
323098008730	lipid binding site [chemical binding]; lipid-binding site
323098008731	Transposase; Region: HTH_Tnp_1; pfam01527
323098008732	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323098008733	Helix-turn-helix domain; Region: HTH_28; pfam13518
323098008734	putative transposase OrfB; Reviewed; Region: PHA02517
323098008735	Homeodomain-like domain; Region: HTH_32; pfam13565
323098008736	Integrase core domain; Region: rve; pfam00665
323098008737	Integrase core domain; Region: rve_3; pfam13683
323098008738	Protein of unknown function, DUF488; Region: DUF488; pfam04343
323098008739	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
323098008740	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
323098008741	catalytic residues [active]
323098008742	catalytic nucleophile [active]
323098008743	Recombinase; Region: Recombinase; pfam07508
323098008744	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
323098008745	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
323098008746	Helix-turn-helix domain; Region: HTH_28; pfam13518
323098008747	Winged helix-turn helix; Region: HTH_29; pfam13551
323098008748	Homeodomain-like domain; Region: HTH_32; pfam13565
323098008749	Integrase core domain; Region: rve; pfam00665
323098008750	Integrase core domain; Region: rve_3; pfam13683
323098008751	Transposase; Region: HTH_Tnp_1; cl17663
323098008752	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
323098008753	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
323098008754	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323098008755	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
323098008756	Helix-turn-helix domain; Region: HTH_36; pfam13730
323098008757	group I intron endonuclease; Region: grpIintron_endo; TIGR01453
323098008758	Virulence protein [General function prediction only]; Region: COG3943
323098008759	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
323098008760	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
323098008761	Domain of unknown function (DUF4263); Region: DUF4263; pfam14082
323098008762	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
323098008763	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
323098008764	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
323098008765	dimerization interface [polypeptide binding]; other site
323098008766	putative DNA binding site [nucleotide binding]; other site
323098008767	putative Zn2+ binding site [ion binding]; other site
323098008768	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
323098008769	Low molecular weight phosphatase family; Region: LMWPc; cl00105
323098008770	active site
323098008771	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
323098008772	ArsC family; Region: ArsC; pfam03960
323098008773	catalytic residues [active]
323098008774	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
323098008775	arsenical-resistance protein; Region: acr3; TIGR00832
323098008776	arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690
323098008777	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
323098008778	YtkA-like; Region: YtkA; pfam13115
323098008779	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
323098008780	HlyD family secretion protein; Region: HlyD_3; pfam13437
323098008781	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
323098008782	Protein of unknown function, DUF; Region: DUF411; cl01142
323098008783	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
323098008784	DNA binding residues [nucleotide binding]
323098008785	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
323098008786	dimer interface [polypeptide binding]; other site
323098008787	putative metal binding site [ion binding]; other site
323098008788	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
323098008789	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
323098008790	metal-binding site [ion binding]
323098008791	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
323098008792	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
323098008793	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
323098008794	active site
323098008795	catalytic residues [active]
323098008796	DNA binding site [nucleotide binding]
323098008797	Int/Topo IB signature motif; other site
323098008798	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
323098008799	DNA binding site [nucleotide binding]
323098008800	active site
323098008801	Int/Topo IB signature motif; other site
323098008802	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
323098008803	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
323098008804	catalytic residues [active]
323098008805	catalytic nucleophile [active]
323098008806	Recombinase; Region: Recombinase; pfam07508
323098008807	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
323098008808	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
323098008809	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
323098008810	Zn2+ binding site [ion binding]; other site
323098008811	Mg2+ binding site [ion binding]; other site
323098008812	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239