-- dump date 20140619_164245 -- class Genbank::misc_feature -- table misc_feature_note -- id note 472759000001 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 472759000002 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 472759000003 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 472759000004 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 472759000005 ATP binding site [chemical binding]; other site 472759000006 putative Mg++ binding site [ion binding]; other site 472759000007 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 472759000008 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 472759000009 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 472759000010 HsdM N-terminal domain; Region: HsdM_N; pfam12161 472759000011 Methyltransferase domain; Region: Methyltransf_26; pfam13659 472759000012 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 472759000013 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 472759000014 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 472759000015 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 472759000016 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 472759000017 non-specific DNA binding site [nucleotide binding]; other site 472759000018 salt bridge; other site 472759000019 sequence-specific DNA binding site [nucleotide binding]; other site 472759000020 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 472759000021 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 472759000022 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 472759000023 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 472759000024 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 472759000025 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 472759000026 Rubrerythrin [Energy production and conversion]; Region: COG1592 472759000027 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 472759000028 iron binding site [ion binding]; other site 472759000029 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 472759000030 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 472759000031 Domain of unknown function (DUF932); Region: DUF932; pfam06067 472759000032 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 472759000033 HicB family; Region: HicB; pfam05534 472759000034 Type II transport protein GspH; Region: GspH; pfam12019 472759000035 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 472759000036 catalytic motif [active] 472759000037 Catalytic residue [active] 472759000038 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 472759000039 putative active site [active] 472759000040 putative catalytic site [active] 472759000041 putative Mg binding site IVb [ion binding]; other site 472759000042 putative phosphate binding site [ion binding]; other site 472759000043 putative DNA binding site [nucleotide binding]; other site 472759000044 putative Mg binding site IVa [ion binding]; other site 472759000045 Lamin Tail Domain; Region: LTD; pfam00932 472759000046 Restriction endonuclease; Region: Mrr_cat; pfam04471 472759000047 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 472759000048 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 472759000049 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 472759000050 Magnesium ion binding site [ion binding]; other site 472759000051 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 472759000052 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 472759000053 P-loop; other site 472759000054 Magnesium ion binding site [ion binding]; other site 472759000055 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 472759000056 Magnesium ion binding site [ion binding]; other site 472759000057 ParB-like nuclease domain; Region: ParB; smart00470 472759000058 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 472759000059 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 472759000060 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 472759000061 active site 472759000062 DNA binding site [nucleotide binding] 472759000063 Int/Topo IB signature motif; other site 472759000064 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 472759000065 DNA binding site [nucleotide binding] 472759000066 dimer interface [polypeptide binding]; other site 472759000067 active site 472759000068 Int/Topo IB signature motif; other site 472759000069 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 472759000070 Restriction endonuclease; Region: Mrr_cat; pfam04471 472759000071 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861 472759000072 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 472759000073 active site 472759000074 Domain of unknown function (DUF4297); Region: DUF4297; pfam14130 472759000075 M28 Zn-Peptidases; Region: M28_like_1; cd05640 472759000076 Peptidase family M28; Region: Peptidase_M28; pfam04389 472759000077 metal binding site [ion binding]; metal-binding site 472759000078 DEAD-like helicases superfamily; Region: DEXDc; smart00487 472759000079 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 472759000080 ATP binding site [chemical binding]; other site 472759000081 putative Mg++ binding site [ion binding]; other site 472759000082 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 472759000083 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 472759000084 nucleotide binding region [chemical binding]; other site 472759000085 ATP-binding site [chemical binding]; other site 472759000086 Putative molybdenum carrier; Region: MoCo_carrier; pfam12694 472759000087 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 472759000088 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 472759000089 AAA domain; Region: AAA_22; pfam13401 472759000090 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 472759000091 DnaA N-terminal domain; Region: DnaA_N; pfam11638 472759000092 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759000093 Walker A motif; other site 472759000094 ATP binding site [chemical binding]; other site 472759000095 Walker B motif; other site 472759000096 arginine finger; other site 472759000097 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 472759000098 DnaA box-binding interface [nucleotide binding]; other site 472759000099 DNA polymerase III subunit beta; Validated; Region: PRK05643 472759000100 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 472759000101 putative DNA binding surface [nucleotide binding]; other site 472759000102 dimer interface [polypeptide binding]; other site 472759000103 beta-clamp/clamp loader binding surface; other site 472759000104 beta-clamp/translesion DNA polymerase binding surface; other site 472759000105 recombination protein F; Reviewed; Region: recF; PRK00064 472759000106 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 472759000107 Walker A/P-loop; other site 472759000108 ATP binding site [chemical binding]; other site 472759000109 Q-loop/lid; other site 472759000110 ABC transporter signature motif; other site 472759000111 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 472759000112 ABC transporter signature motif; other site 472759000113 Walker B; other site 472759000114 D-loop; other site 472759000115 H-loop/switch region; other site 472759000116 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 472759000117 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 472759000118 Mg2+ binding site [ion binding]; other site 472759000119 G-X-G motif; other site 472759000120 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 472759000121 anchoring element; other site 472759000122 dimer interface [polypeptide binding]; other site 472759000123 ATP binding site [chemical binding]; other site 472759000124 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 472759000125 active site 472759000126 putative metal-binding site [ion binding]; other site 472759000127 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 472759000128 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 472759000129 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 472759000130 dihydropteroate synthase-related protein; Region: TIGR00284 472759000131 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 472759000132 substrate binding pocket [chemical binding]; other site 472759000133 dimer interface [polypeptide binding]; other site 472759000134 inhibitor binding site; inhibition site 472759000135 Protein of unknown function (DUF447); Region: DUF447; pfam04289 472759000136 hypothetical protein; Provisional; Region: PRK02227 472759000137 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 472759000138 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 472759000139 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 472759000140 Multicopper oxidase; Region: Cu-oxidase; pfam00394 472759000141 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 472759000142 AMP binding site [chemical binding]; other site 472759000143 metal binding site [ion binding]; metal-binding site 472759000144 active site 472759000145 formylmethanofuran dehydrogenase subunit C; Region: one_C_dehyd_C; TIGR03122 472759000146 domain_subunit interface; other site 472759000147 formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114 472759000148 Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913 472759000149 FTR, proximal lobe; Region: FTR_C; pfam02741 472759000150 formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121 472759000151 Formylmethanofuran dehydrogenase (FMDH) subunit A; Methanogenic bacteria and archea derive the energy for autotrophic growth from methanogenesis, the reduction of CO2 with molecular hydrogen as the electron donor. FMDH catalyzes the first step in...; Region: FMDH_A; cd01304 472759000152 active site 472759000153 formylmethanofuran dehydrogenase subunit B; Region: one_C_dehyd_B; TIGR03129 472759000154 The MopB_FmdB-FwdB CD contains the molybdenum/tungsten formylmethanofuran dehydrogenases, subunit B (FmdB/FwdB), and other related proteins. Formylmethanofuran dehydrogenase catalyzes the first step in methane formation from CO2 in methanogenic archaea...; Region: MopB_FmdB-FwdB; cd02761 472759000155 putative [4Fe-4S] binding site [ion binding]; other site 472759000156 putative molybdopterin cofactor binding site [chemical binding]; other site 472759000157 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 472759000158 aromatic arch; other site 472759000159 DCoH dimer interaction site [polypeptide binding]; other site 472759000160 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 472759000161 DCoH tetramer interaction site [polypeptide binding]; other site 472759000162 substrate binding site [chemical binding]; other site 472759000163 Sporulation related domain; Region: SPOR; pfam05036 472759000164 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 472759000165 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 472759000166 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 472759000167 active site 472759000168 HIGH motif; other site 472759000169 nucleotide binding site [chemical binding]; other site 472759000170 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 472759000171 KMSK motif region; other site 472759000172 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 472759000173 tRNA binding surface [nucleotide binding]; other site 472759000174 anticodon binding site; other site 472759000175 primosome assembly protein PriA; Validated; Region: PRK05580 472759000176 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 472759000177 ATP binding site [chemical binding]; other site 472759000178 putative Mg++ binding site [ion binding]; other site 472759000179 helicase superfamily c-terminal domain; Region: HELICc; smart00490 472759000180 DJ-1 family protein; Region: not_thiJ; TIGR01383 472759000181 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 472759000182 conserved cys residue [active] 472759000183 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 472759000184 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 472759000185 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 472759000186 protein binding site [polypeptide binding]; other site 472759000187 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 472759000188 Catalytic dyad [active] 472759000189 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 472759000190 phosphoglyceromutase; Provisional; Region: PRK05434 472759000191 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 472759000192 active site residue [active] 472759000193 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 472759000194 GSH binding site [chemical binding]; other site 472759000195 catalytic residues [active] 472759000196 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 472759000197 SecA binding site; other site 472759000198 Preprotein binding site; other site 472759000199 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 472759000200 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 472759000201 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 472759000202 Short C-terminal domain; Region: SHOCT; pfam09851 472759000203 Uncharacterized conserved protein [Function unknown]; Region: COG1565 472759000204 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 472759000205 catalytic center binding site [active] 472759000206 ATP binding site [chemical binding]; other site 472759000207 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 472759000208 homooctamer interface [polypeptide binding]; other site 472759000209 active site 472759000210 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 472759000211 UGMP family protein; Validated; Region: PRK09604 472759000212 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 472759000213 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 472759000214 Yqey-like protein; Region: YqeY; pfam09424 472759000215 DNA primase, catalytic core; Region: dnaG; TIGR01391 472759000216 CHC2 zinc finger; Region: zf-CHC2; pfam01807 472759000217 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 472759000218 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 472759000219 active site 472759000220 metal binding site [ion binding]; metal-binding site 472759000221 interdomain interaction site; other site 472759000222 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 472759000223 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 472759000224 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 472759000225 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 472759000226 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 472759000227 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 472759000228 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 472759000229 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 472759000230 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 472759000231 DNA binding residues [nucleotide binding] 472759000232 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 472759000233 Catalytic site; other site 472759000234 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 472759000235 salt bridge; other site 472759000236 non-specific DNA binding site [nucleotide binding]; other site 472759000237 sequence-specific DNA binding site [nucleotide binding]; other site 472759000238 putative cation:proton antiport protein; Provisional; Region: PRK10669 472759000239 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 472759000240 TrkA-N domain; Region: TrkA_N; pfam02254 472759000241 amino acid transporter; Region: 2A0306; TIGR00909 472759000242 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 472759000243 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 472759000244 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 472759000245 TrkA-N domain; Region: TrkA_N; pfam02254 472759000246 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 472759000247 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 472759000248 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 472759000249 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 472759000250 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 472759000251 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 472759000252 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 472759000253 nucleotide binding site/active site [active] 472759000254 HIT family signature motif; other site 472759000255 catalytic residue [active] 472759000256 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 472759000257 metal binding site [ion binding]; metal-binding site 472759000258 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 472759000259 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 472759000260 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 472759000261 substrate binding site [chemical binding]; other site 472759000262 glutamase interaction surface [polypeptide binding]; other site 472759000263 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 472759000264 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 472759000265 catalytic residues [active] 472759000266 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 472759000267 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 472759000268 putative active site [active] 472759000269 oxyanion strand; other site 472759000270 catalytic triad [active] 472759000271 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 472759000272 putative active site pocket [active] 472759000273 4-fold oligomerization interface [polypeptide binding]; other site 472759000274 metal binding residues [ion binding]; metal-binding site 472759000275 3-fold/trimer interface [polypeptide binding]; other site 472759000276 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 472759000277 Cytochrome c553 [Energy production and conversion]; Region: COG2863 472759000278 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 472759000279 Cytochrome c553 [Energy production and conversion]; Region: COG2863 472759000280 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 472759000281 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 472759000282 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 472759000283 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 472759000284 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 472759000285 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 472759000286 Subunit I/III interface [polypeptide binding]; other site 472759000287 D-pathway; other site 472759000288 Subunit I/VIIc interface [polypeptide binding]; other site 472759000289 Subunit I/IV interface [polypeptide binding]; other site 472759000290 Subunit I/II interface [polypeptide binding]; other site 472759000291 Low-spin heme (heme a) binding site [chemical binding]; other site 472759000292 Subunit I/VIIa interface [polypeptide binding]; other site 472759000293 Subunit I/VIa interface [polypeptide binding]; other site 472759000294 Dimer interface; other site 472759000295 Putative water exit pathway; other site 472759000296 Binuclear center (heme a3/CuB) [ion binding]; other site 472759000297 K-pathway; other site 472759000298 Subunit I/Vb interface [polypeptide binding]; other site 472759000299 Putative proton exit pathway; other site 472759000300 Subunit I/VIb interface; other site 472759000301 Subunit I/VIc interface [polypeptide binding]; other site 472759000302 Electron transfer pathway; other site 472759000303 Subunit I/VIIIb interface [polypeptide binding]; other site 472759000304 Subunit I/VIIb interface [polypeptide binding]; other site 472759000305 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 472759000306 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 472759000307 Subunit III/VIIa interface [polypeptide binding]; other site 472759000308 Phospholipid binding site [chemical binding]; other site 472759000309 Subunit I/III interface [polypeptide binding]; other site 472759000310 Subunit III/VIb interface [polypeptide binding]; other site 472759000311 Subunit III/VIa interface; other site 472759000312 Subunit III/Vb interface [polypeptide binding]; other site 472759000313 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 472759000314 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 472759000315 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 472759000316 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 472759000317 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 472759000318 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 472759000319 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 472759000320 UbiA prenyltransferase family; Region: UbiA; pfam01040 472759000321 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 472759000322 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 472759000323 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 472759000324 gamma-glutamyl kinase; Provisional; Region: PRK05429 472759000325 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 472759000326 nucleotide binding site [chemical binding]; other site 472759000327 homotetrameric interface [polypeptide binding]; other site 472759000328 putative phosphate binding site [ion binding]; other site 472759000329 putative allosteric binding site; other site 472759000330 PUA domain; Region: PUA; pfam01472 472759000331 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 472759000332 GTP1/OBG; Region: GTP1_OBG; pfam01018 472759000333 Obg GTPase; Region: Obg; cd01898 472759000334 G1 box; other site 472759000335 GTP/Mg2+ binding site [chemical binding]; other site 472759000336 Switch I region; other site 472759000337 G2 box; other site 472759000338 G3 box; other site 472759000339 Switch II region; other site 472759000340 G4 box; other site 472759000341 G5 box; other site 472759000342 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 472759000343 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 472759000344 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 472759000345 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 472759000346 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 472759000347 substrate binding pocket [chemical binding]; other site 472759000348 chain length determination region; other site 472759000349 substrate-Mg2+ binding site; other site 472759000350 catalytic residues [active] 472759000351 aspartate-rich region 1; other site 472759000352 active site lid residues [active] 472759000353 aspartate-rich region 2; other site 472759000354 EVE domain; Region: EVE; cl00728 472759000355 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 472759000356 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 472759000357 non-specific DNA binding site [nucleotide binding]; other site 472759000358 salt bridge; other site 472759000359 sequence-specific DNA binding site [nucleotide binding]; other site 472759000360 DEAD-like helicases superfamily; Region: DEXDc; smart00487 472759000361 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 472759000362 ATP binding site [chemical binding]; other site 472759000363 putative Mg++ binding site [ion binding]; other site 472759000364 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 472759000365 nucleotide binding region [chemical binding]; other site 472759000366 ATP-binding site [chemical binding]; other site 472759000367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 472759000368 ATP binding site [chemical binding]; other site 472759000369 Mg2+ binding site [ion binding]; other site 472759000370 G-X-G motif; other site 472759000371 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 472759000372 putative homodimer interface [polypeptide binding]; other site 472759000373 putative active site [active] 472759000374 catalytic site [active] 472759000375 Protein of unknown function DUF262; Region: DUF262; pfam03235 472759000376 Uncharacterized conserved protein [Function unknown]; Region: COG1479 472759000377 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 472759000378 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 472759000379 Active Sites [active] 472759000380 Radical SAM superfamily; Region: Radical_SAM; pfam04055 472759000381 P-loop containing region of AAA domain; Region: AAA_29; cl17516 472759000382 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 472759000383 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 472759000384 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 472759000385 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 472759000386 catalytic residue [active] 472759000387 DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096 472759000388 Peptidase M15; Region: Peptidase_M15_3; cl01194 472759000389 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 472759000390 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 472759000391 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 472759000392 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 472759000393 HlyD family secretion protein; Region: HlyD_3; pfam13437 472759000394 multidrug efflux protein; Reviewed; Region: PRK09579 472759000395 Protein export membrane protein; Region: SecD_SecF; cl14618 472759000396 Uncharacterized subfamily of glycoside hydrolase family 57 (GH57); Region: GH57N_like_1; cd10798 472759000397 active site 472759000398 catalytic site [active] 472759000399 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 472759000400 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 472759000401 active site 472759000402 FMN binding site [chemical binding]; other site 472759000403 substrate binding site [chemical binding]; other site 472759000404 3Fe-4S cluster binding site [ion binding]; other site 472759000405 glycogen synthase; Provisional; Region: glgA; PRK00654 472759000406 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 472759000407 ADP-binding pocket [chemical binding]; other site 472759000408 homodimer interface [polypeptide binding]; other site 472759000409 Uncharacterized conserved protein [Function unknown]; Region: COG1543 472759000410 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 472759000411 active site 472759000412 substrate binding site [chemical binding]; other site 472759000413 catalytic site [active] 472759000414 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 472759000415 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 472759000416 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 472759000417 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 472759000418 TPP-binding site [chemical binding]; other site 472759000419 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 472759000420 dimer interface [polypeptide binding]; other site 472759000421 PYR/PP interface [polypeptide binding]; other site 472759000422 TPP binding site [chemical binding]; other site 472759000423 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 472759000424 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 472759000425 E3 interaction surface; other site 472759000426 lipoyl attachment site [posttranslational modification]; other site 472759000427 e3 binding domain; Region: E3_binding; pfam02817 472759000428 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 472759000429 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 472759000430 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 472759000431 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 472759000432 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 472759000433 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 472759000434 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 472759000435 His-Xaa-Ser system putative quinone modification maturase; Region: SAM_quin_mod; TIGR03981 472759000436 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 472759000437 Domain of unknown function DUF21; Region: DUF21; pfam01595 472759000438 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 472759000439 Transporter associated domain; Region: CorC_HlyC; smart01091 472759000440 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 472759000441 Domain of unknown function DUF21; Region: DUF21; pfam01595 472759000442 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 472759000443 Transporter associated domain; Region: CorC_HlyC; smart01091 472759000444 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 472759000445 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 472759000446 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 472759000447 Beta-Casp domain; Region: Beta-Casp; smart01027 472759000448 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 472759000449 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 472759000450 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 472759000451 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 472759000452 putative NAD(P) binding site [chemical binding]; other site 472759000453 active site 472759000454 PAS domain S-box; Region: sensory_box; TIGR00229 472759000455 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 472759000456 putative active site [active] 472759000457 heme pocket [chemical binding]; other site 472759000458 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 472759000459 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 472759000460 putative active site [active] 472759000461 heme pocket [chemical binding]; other site 472759000462 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 472759000463 dimer interface [polypeptide binding]; other site 472759000464 phosphorylation site [posttranslational modification] 472759000465 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 472759000466 ATP binding site [chemical binding]; other site 472759000467 Mg2+ binding site [ion binding]; other site 472759000468 G-X-G motif; other site 472759000469 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 472759000470 DNA-binding site [nucleotide binding]; DNA binding site 472759000471 RNA-binding motif; other site 472759000472 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 472759000473 YcfA-like protein; Region: YcfA; pfam07927 472759000474 toxin-antitoxin system, toxin component, Txe/YoeB family; Region: toxin_Txe_YoeB; TIGR02116 472759000475 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 472759000476 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304 472759000477 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 472759000478 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 472759000479 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 472759000480 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 472759000481 active site 472759000482 DNA binding site [nucleotide binding] 472759000483 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 472759000484 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 472759000485 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 472759000486 ABC transporter signature motif; other site 472759000487 Walker B; other site 472759000488 D-loop; other site 472759000489 H-loop/switch region; other site 472759000490 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 472759000491 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 472759000492 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 472759000493 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 472759000494 Walker A/P-loop; other site 472759000495 ATP binding site [chemical binding]; other site 472759000496 Q-loop/lid; other site 472759000497 ABC transporter signature motif; other site 472759000498 Walker B; other site 472759000499 D-loop; other site 472759000500 H-loop/switch region; other site 472759000501 Domain of unknown function (DUF427); Region: DUF427; pfam04248 472759000502 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 472759000503 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 472759000504 putative active site [active] 472759000505 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 472759000506 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 472759000507 putative active site [active] 472759000508 Domain of unknown function (DUF1704); Region: DUF1704; pfam08014 472759000509 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 472759000510 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 472759000511 putative NAD(P) binding site [chemical binding]; other site 472759000512 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 472759000513 Fatty acid desaturase; Region: FA_desaturase; pfam00487 472759000514 Di-iron ligands [ion binding]; other site 472759000515 Transposase; Region: DDE_Tnp_ISL3; pfam01610 472759000516 Predicted amidohydrolase [General function prediction only]; Region: COG0388 472759000517 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 472759000518 putative active site [active] 472759000519 catalytic triad [active] 472759000520 putative dimer interface [polypeptide binding]; other site 472759000521 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 472759000522 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 472759000523 Walker A/P-loop; other site 472759000524 ATP binding site [chemical binding]; other site 472759000525 Q-loop/lid; other site 472759000526 ABC transporter signature motif; other site 472759000527 Walker B; other site 472759000528 D-loop; other site 472759000529 H-loop/switch region; other site 472759000530 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 472759000531 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 472759000532 Walker A/P-loop; other site 472759000533 ATP binding site [chemical binding]; other site 472759000534 Q-loop/lid; other site 472759000535 ABC transporter signature motif; other site 472759000536 Walker B; other site 472759000537 D-loop; other site 472759000538 H-loop/switch region; other site 472759000539 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 472759000540 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 472759000541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 472759000542 dimer interface [polypeptide binding]; other site 472759000543 conserved gate region; other site 472759000544 putative PBP binding loops; other site 472759000545 ABC-ATPase subunit interface; other site 472759000546 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 472759000547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 472759000548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 472759000549 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 472759000550 ABC-ATPase subunit interface; other site 472759000551 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 472759000552 peptide binding site [polypeptide binding]; other site 472759000553 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 472759000554 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 472759000555 AAA ATPase domain; Region: AAA_15; pfam13175 472759000556 Domain of unknown function DUF29; Region: DUF29; pfam01724 472759000557 SnoaL-like domain; Region: SnoaL_2; pfam12680 472759000558 Domain of unknown function DUF29; Region: DUF29; pfam01724 472759000559 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 472759000560 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 472759000561 oligomerisation interface [polypeptide binding]; other site 472759000562 mobile loop; other site 472759000563 roof hairpin; other site 472759000564 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 472759000565 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 472759000566 ring oligomerisation interface [polypeptide binding]; other site 472759000567 ATP/Mg binding site [chemical binding]; other site 472759000568 stacking interactions; other site 472759000569 hinge regions; other site 472759000570 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 472759000571 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 472759000572 DNA binding residues [nucleotide binding] 472759000573 dimer interface [polypeptide binding]; other site 472759000574 copper binding site [ion binding]; other site 472759000575 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 472759000576 metal-binding site [ion binding] 472759000577 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 472759000578 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 472759000579 metal-binding site [ion binding] 472759000580 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 472759000581 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 472759000582 metal-binding site [ion binding] 472759000583 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 472759000584 Soluble P-type ATPase [General function prediction only]; Region: COG4087 472759000585 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 472759000586 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 472759000587 oligomeric interface; other site 472759000588 putative active site [active] 472759000589 homodimer interface [polypeptide binding]; other site 472759000590 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 472759000591 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 472759000592 metal binding triad; other site 472759000593 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 472759000594 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 472759000595 metal binding triad; other site 472759000596 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 472759000597 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 472759000598 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 472759000599 homodimer interface [polypeptide binding]; other site 472759000600 substrate-cofactor binding pocket; other site 472759000601 catalytic residue [active] 472759000602 hypothetical protein; Validated; Region: PRK00110 472759000603 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 472759000604 active site 472759000605 putative DNA-binding cleft [nucleotide binding]; other site 472759000606 dimer interface [polypeptide binding]; other site 472759000607 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 472759000608 RuvA N terminal domain; Region: RuvA_N; pfam01330 472759000609 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 472759000610 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 472759000611 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759000612 Walker A motif; other site 472759000613 ATP binding site [chemical binding]; other site 472759000614 Walker B motif; other site 472759000615 arginine finger; other site 472759000616 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 472759000617 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 472759000618 active site 472759000619 TolQ protein; Region: tolQ; TIGR02796 472759000620 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 472759000621 TolR protein; Region: tolR; TIGR02801 472759000622 TolA protein; Region: tolA_full; TIGR02794 472759000623 TonB C terminal; Region: TonB_2; pfam13103 472759000624 translocation protein TolB; Provisional; Region: tolB; PRK04922 472759000625 TolB amino-terminal domain; Region: TolB_N; pfam04052 472759000626 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 472759000627 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 472759000628 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 472759000629 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 472759000630 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 472759000631 ligand binding site [chemical binding]; other site 472759000632 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 472759000633 Tetratricopeptide repeat; Region: TPR_6; pfam13174 472759000634 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 472759000635 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 472759000636 FeS/SAM binding site; other site 472759000637 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 472759000638 Ligand Binding Site [chemical binding]; other site 472759000639 M28 Zn-Peptidases; Region: M28_like_1; cd05640 472759000640 Peptidase family M28; Region: Peptidase_M28; pfam04389 472759000641 metal binding site [ion binding]; metal-binding site 472759000642 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 472759000643 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 472759000644 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 472759000645 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 472759000646 CHRD domain; Region: CHRD; pfam07452 472759000647 Outer membrane lipoprotein Slp family; Region: Slp; pfam03843 472759000648 Outer membrane lipoprotein Slp family; Region: Slp; pfam03843 472759000649 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 472759000650 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 472759000651 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 472759000652 non-specific DNA binding site [nucleotide binding]; other site 472759000653 salt bridge; other site 472759000654 sequence-specific DNA binding site [nucleotide binding]; other site 472759000655 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 472759000656 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 472759000657 binding surface 472759000658 Tetratricopeptide repeat; Region: TPR_16; pfam13432 472759000659 TPR motif; other site 472759000660 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 472759000661 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 472759000662 FAD binding pocket [chemical binding]; other site 472759000663 FAD binding motif [chemical binding]; other site 472759000664 phosphate binding motif [ion binding]; other site 472759000665 beta-alpha-beta structure motif; other site 472759000666 NAD binding pocket [chemical binding]; other site 472759000667 Iron coordination center [ion binding]; other site 472759000668 dihydroorotase; Provisional; Region: PRK07627 472759000669 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 472759000670 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 472759000671 active site 472759000672 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 472759000673 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 472759000674 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 472759000675 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 472759000676 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 472759000677 active site 472759000678 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 472759000679 hypothetical protein; Validated; Region: PRK00228 472759000680 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 472759000681 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 472759000682 glutathione synthetase; Provisional; Region: PRK05246 472759000683 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 472759000684 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 472759000685 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 472759000686 Surface antigen; Region: Bac_surface_Ag; pfam01103 472759000687 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 472759000688 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 472759000689 Family of unknown function (DUF490); Region: DUF490; pfam04357 472759000690 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 472759000691 dimer interface [polypeptide binding]; other site 472759000692 motif 1; other site 472759000693 active site 472759000694 motif 2; other site 472759000695 motif 3; other site 472759000696 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 472759000697 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 472759000698 DALR anticodon binding domain; Region: DALR_1; pfam05746 472759000699 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 472759000700 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 472759000701 active site 472759000702 motif I; other site 472759000703 motif II; other site 472759000704 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 472759000705 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 472759000706 putative acyl-acceptor binding pocket; other site 472759000707 PAS domain S-box; Region: sensory_box; TIGR00229 472759000708 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 472759000709 putative active site [active] 472759000710 heme pocket [chemical binding]; other site 472759000711 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 472759000712 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 472759000713 metal binding site [ion binding]; metal-binding site 472759000714 active site 472759000715 I-site; other site 472759000716 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 472759000717 heat shock protein HtpX; Provisional; Region: PRK02391 472759000718 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 472759000719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 472759000720 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 472759000721 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 472759000722 AAA domain; Region: AAA_33; pfam13671 472759000723 active site 472759000724 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 472759000725 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 472759000726 active site 472759000727 NTP binding site [chemical binding]; other site 472759000728 metal binding triad [ion binding]; metal-binding site 472759000729 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 472759000730 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 472759000731 Zn2+ binding site [ion binding]; other site 472759000732 Mg2+ binding site [ion binding]; other site 472759000733 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 472759000734 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 472759000735 putative NAD(P) binding site [chemical binding]; other site 472759000736 active site 472759000737 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 472759000738 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 472759000739 NAD(P) binding site [chemical binding]; other site 472759000740 catalytic residues [active] 472759000741 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 472759000742 Response regulator receiver domain; Region: Response_reg; pfam00072 472759000743 active site 472759000744 phosphorylation site [posttranslational modification] 472759000745 intermolecular recognition site; other site 472759000746 dimerization interface [polypeptide binding]; other site 472759000747 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 472759000748 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759000749 S-adenosylmethionine binding site [chemical binding]; other site 472759000750 Protein of unknown function (DUF523); Region: DUF523; pfam04463 472759000751 Uncharacterized conserved protein [Function unknown]; Region: COG3272 472759000752 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 472759000753 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 472759000754 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 472759000755 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 472759000756 RES domain; Region: RES; pfam08808 472759000757 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 472759000758 Sel1 repeat; Region: Sel1; cl02723 472759000759 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 472759000760 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 472759000761 salt bridge; other site 472759000762 non-specific DNA binding site [nucleotide binding]; other site 472759000763 sequence-specific DNA binding site [nucleotide binding]; other site 472759000764 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 472759000765 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 472759000766 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 472759000767 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 472759000768 conserved cys residue [active] 472759000769 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 472759000770 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 472759000771 P-loop; other site 472759000772 Transposase IS200 like; Region: Y1_Tnp; pfam01797 472759000773 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 472759000774 DNA photolyase; Region: DNA_photolyase; pfam00875 472759000775 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 472759000776 classical (c) SDRs; Region: SDR_c; cd05233 472759000777 NAD(P) binding site [chemical binding]; other site 472759000778 active site 472759000779 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 472759000780 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 472759000781 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 472759000782 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 472759000783 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 472759000784 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 472759000785 DNA binding residues [nucleotide binding] 472759000786 B12 binding domain; Region: B12-binding_2; pfam02607 472759000787 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 472759000788 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 472759000789 ATP binding site [chemical binding]; other site 472759000790 substrate interface [chemical binding]; other site 472759000791 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 472759000792 MPN+ (JAMM) motif; other site 472759000793 Zinc-binding site [ion binding]; other site 472759000794 peptidase PmbA; Provisional; Region: PRK11040 472759000795 Protein of unknown function (DUF533); Region: DUF533; pfam04391 472759000796 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 472759000797 putative metal binding site [ion binding]; other site 472759000798 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 472759000799 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 472759000800 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 472759000801 Cl- selectivity filter; other site 472759000802 Cl- binding residues [ion binding]; other site 472759000803 pore gating glutamate residue; other site 472759000804 dimer interface [polypeptide binding]; other site 472759000805 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 472759000806 PemK-like protein; Region: PemK; cl00995 472759000807 Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336 472759000808 HemK family putative methylases; Region: hemK_fam; TIGR00536 472759000809 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759000810 S-adenosylmethionine binding site [chemical binding]; other site 472759000811 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 472759000812 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 472759000813 substrate binding site [chemical binding]; other site 472759000814 ligand binding site [chemical binding]; other site 472759000815 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 472759000816 Protein export membrane protein; Region: SecD_SecF; cl14618 472759000817 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 472759000818 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 472759000819 HlyD family secretion protein; Region: HlyD_3; pfam13437 472759000820 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 472759000821 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 472759000822 Tetramer interface [polypeptide binding]; other site 472759000823 active site 472759000824 FMN-binding site [chemical binding]; other site 472759000825 CHRD domain; Region: CHRD; pfam07452 472759000826 Spondin_N; Region: Spond_N; pfam06468 472759000827 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 472759000828 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 472759000829 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 472759000830 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 472759000831 putative active site [active] 472759000832 putative Zn binding site [ion binding]; other site 472759000833 Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538 472759000834 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 472759000835 putative DNA binding site [nucleotide binding]; other site 472759000836 Low molecular weight phosphatase family; Region: LMWPc; cd00115 472759000837 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 472759000838 active site 472759000839 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 472759000840 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 472759000841 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 472759000842 HI0933-like protein; Region: HI0933_like; pfam03486 472759000843 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 472759000844 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 472759000845 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 472759000846 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 472759000847 Zn binding site [ion binding]; other site 472759000848 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 472759000849 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759000850 S-adenosylmethionine binding site [chemical binding]; other site 472759000851 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 472759000852 Fatty acid desaturase; Region: FA_desaturase; pfam00487 472759000853 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 472759000854 Di-iron ligands [ion binding]; other site 472759000855 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 472759000856 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 472759000857 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 472759000858 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 472759000859 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 472759000860 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 472759000861 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 472759000862 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759000863 S-adenosylmethionine binding site [chemical binding]; other site 472759000864 Transposase, Mutator family; Region: Transposase_mut; pfam00872 472759000865 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 472759000866 Predicted transcriptional regulator [Transcription]; Region: COG3905 472759000867 PemK-like protein; Region: PemK; pfam02452 472759000868 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 472759000869 MFS_1 like family; Region: MFS_1_like; pfam12832 472759000870 malate dehydrogenase; Reviewed; Region: PRK06223 472759000871 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 472759000872 NAD(P) binding site [chemical binding]; other site 472759000873 dimer interface [polypeptide binding]; other site 472759000874 tetramer (dimer of dimers) interface [polypeptide binding]; other site 472759000875 substrate binding site [chemical binding]; other site 472759000876 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 472759000877 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 472759000878 MgtE intracellular N domain; Region: MgtE_N; smart00924 472759000879 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 472759000880 Divalent cation transporter; Region: MgtE; cl00786 472759000881 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 472759000882 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 472759000883 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 472759000884 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 472759000885 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 472759000886 dimerization domain swap beta strand [polypeptide binding]; other site 472759000887 regulatory protein interface [polypeptide binding]; other site 472759000888 active site 472759000889 regulatory phosphorylation site [posttranslational modification]; other site 472759000890 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 472759000891 active pocket/dimerization site; other site 472759000892 active site 472759000893 phosphorylation site [posttranslational modification] 472759000894 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 472759000895 HPr kinase/phosphorylase; Provisional; Region: PRK05428 472759000896 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 472759000897 Hpr binding site; other site 472759000898 active site 472759000899 homohexamer subunit interaction site [polypeptide binding]; other site 472759000900 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 472759000901 active site 472759000902 phosphorylation site [posttranslational modification] 472759000903 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 472759000904 30S subunit binding site; other site 472759000905 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 472759000906 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 472759000907 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 472759000908 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 472759000909 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 472759000910 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 472759000911 Walker A/P-loop; other site 472759000912 ATP binding site [chemical binding]; other site 472759000913 Q-loop/lid; other site 472759000914 ABC transporter signature motif; other site 472759000915 Walker B; other site 472759000916 D-loop; other site 472759000917 H-loop/switch region; other site 472759000918 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 472759000919 OstA-like protein; Region: OstA; pfam03968 472759000920 Bacterial SH3 domain; Region: SH3_3; pfam08239 472759000921 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 472759000922 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 472759000923 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 472759000924 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 472759000925 active site 472759000926 motif I; other site 472759000927 motif II; other site 472759000928 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 472759000929 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 472759000930 putative active site [active] 472759000931 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 472759000932 VacJ like lipoprotein; Region: VacJ; cl01073 472759000933 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 472759000934 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 472759000935 Walker A/P-loop; other site 472759000936 ATP binding site [chemical binding]; other site 472759000937 Q-loop/lid; other site 472759000938 ABC transporter signature motif; other site 472759000939 Walker B; other site 472759000940 D-loop; other site 472759000941 H-loop/switch region; other site 472759000942 Permease; Region: Permease; cl00510 472759000943 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 472759000944 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 472759000945 mce related protein; Region: MCE; pfam02470 472759000946 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 472759000947 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 472759000948 anti sigma factor interaction site; other site 472759000949 regulatory phosphorylation site [posttranslational modification]; other site 472759000950 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 472759000951 BolA-like protein; Region: BolA; pfam01722 472759000952 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 472759000953 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 472759000954 hinge; other site 472759000955 active site 472759000956 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 472759000957 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 472759000958 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 472759000959 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 472759000960 NAD binding site [chemical binding]; other site 472759000961 dimerization interface [polypeptide binding]; other site 472759000962 product binding site; other site 472759000963 substrate binding site [chemical binding]; other site 472759000964 zinc binding site [ion binding]; other site 472759000965 catalytic residues [active] 472759000966 histidinol-phosphate aminotransferase; Provisional; Region: PRK04870 472759000967 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 472759000968 pyridoxal 5'-phosphate binding site [chemical binding]; other site 472759000969 homodimer interface [polypeptide binding]; other site 472759000970 catalytic residue [active] 472759000971 Uncharacterized conserved protein [Function unknown]; Region: COG0327 472759000972 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 472759000973 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 472759000974 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 472759000975 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 472759000976 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 472759000977 NAD(P) binding site [chemical binding]; other site 472759000978 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 472759000979 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 472759000980 Probable transposase; Region: OrfB_IS605; pfam01385 472759000981 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 472759000982 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 472759000983 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 472759000984 FMN binding site [chemical binding]; other site 472759000985 active site 472759000986 catalytic residues [active] 472759000987 substrate binding site [chemical binding]; other site 472759000988 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 472759000989 VWA-like domain (DUF2201); Region: DUF2201; pfam09967 472759000990 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 472759000991 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759000992 Walker A motif; other site 472759000993 ATP binding site [chemical binding]; other site 472759000994 Walker B motif; other site 472759000995 arginine finger; other site 472759000996 Amidohydrolase; Region: Amidohydro_2; pfam04909 472759000997 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 472759000998 N-acetyl-D-glucosamine binding site [chemical binding]; other site 472759000999 catalytic residue [active] 472759001000 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 472759001001 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 472759001002 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 472759001003 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 472759001004 putative hydrophobic ligand binding site [chemical binding]; other site 472759001005 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 472759001006 PAS domain; Region: PAS_9; pfam13426 472759001007 putative active site [active] 472759001008 heme pocket [chemical binding]; other site 472759001009 tyrosine decarboxylase; Region: PLN02880 472759001010 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 472759001011 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 472759001012 catalytic residue [active] 472759001013 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 472759001014 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 472759001015 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 472759001016 Probable transposase; Region: OrfB_IS605; pfam01385 472759001017 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 472759001018 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 472759001019 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 472759001020 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 472759001021 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 472759001022 PAS domain S-box; Region: sensory_box; TIGR00229 472759001023 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 472759001024 putative active site [active] 472759001025 heme pocket [chemical binding]; other site 472759001026 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 472759001027 PAS domain; Region: PAS_9; pfam13426 472759001028 putative active site [active] 472759001029 heme pocket [chemical binding]; other site 472759001030 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 472759001031 putative active site [active] 472759001032 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 472759001033 heme pocket [chemical binding]; other site 472759001034 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 472759001035 Uncharacterized membrane protein, required for N-linked glycosylation [General function prediction only]; Region: COG1287 472759001036 RRXRR protein; Region: RRXRR; pfam14239 472759001037 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 472759001038 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 472759001039 active site 472759001040 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 472759001041 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 472759001042 Ligand binding site; other site 472759001043 Putative Catalytic site; other site 472759001044 DXD motif; other site 472759001045 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 472759001046 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 472759001047 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759001048 S-adenosylmethionine binding site [chemical binding]; other site 472759001049 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 472759001050 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 472759001051 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 472759001052 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 472759001053 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 472759001054 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 472759001055 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 472759001056 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 472759001057 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 472759001058 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759001059 Methyltransferase domain; Region: Methyltransf_31; pfam13847 472759001060 S-adenosylmethionine binding site [chemical binding]; other site 472759001061 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 472759001062 binding surface 472759001063 TPR motif; other site 472759001064 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 472759001065 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 472759001066 NAD(P) binding site [chemical binding]; other site 472759001067 homodimer interface [polypeptide binding]; other site 472759001068 substrate binding site [chemical binding]; other site 472759001069 active site 472759001070 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759001071 S-adenosylmethionine binding site [chemical binding]; other site 472759001072 Trm112p-like protein; Region: Trm112p; cl01066 472759001073 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 472759001074 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 472759001075 inhibitor-cofactor binding pocket; inhibition site 472759001076 pyridoxal 5'-phosphate binding site [chemical binding]; other site 472759001077 catalytic residue [active] 472759001078 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 472759001079 ligand binding site; other site 472759001080 tetramer interface; other site 472759001081 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 472759001082 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 472759001083 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 472759001084 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 472759001085 pseudaminic acid synthase; Region: PseI; TIGR03586 472759001086 NeuB family; Region: NeuB; pfam03102 472759001087 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 472759001088 NeuB binding interface [polypeptide binding]; other site 472759001089 putative substrate binding site [chemical binding]; other site 472759001090 Transposase, Mutator family; Region: Transposase_mut; pfam00872 472759001091 MULE transposase domain; Region: MULE; pfam10551 472759001092 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 472759001093 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 472759001094 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 472759001095 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 472759001096 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 472759001097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 472759001098 ATP binding site [chemical binding]; other site 472759001099 Mg2+ binding site [ion binding]; other site 472759001100 G-X-G motif; other site 472759001101 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 472759001102 anti sigma factor interaction site; other site 472759001103 regulatory phosphorylation site [posttranslational modification]; other site 472759001104 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 472759001105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759001106 Walker A motif; other site 472759001107 ATP binding site [chemical binding]; other site 472759001108 Walker B motif; other site 472759001109 R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich...; Region: R3H; cl00297 472759001110 RxxxH motif; other site 472759001111 DoxX; Region: DoxX; pfam07681 472759001112 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 472759001113 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 472759001114 active site 472759001115 catalytic site [active] 472759001116 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 472759001117 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 472759001118 starch-binding site 2 [chemical binding]; other site 472759001119 starch-binding site 1 [chemical binding]; other site 472759001120 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 472759001121 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 472759001122 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 472759001123 FAD binding domain; Region: FAD_binding_4; pfam01565 472759001124 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 472759001125 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 472759001126 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 472759001127 Cysteine-rich domain; Region: CCG; pfam02754 472759001128 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 472759001129 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 472759001130 Predicted nucleotidyltransferase [General function prediction only]; Region: COG1665 472759001131 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 472759001132 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 472759001133 D-pathway; other site 472759001134 Low-spin heme binding site [chemical binding]; other site 472759001135 Putative water exit pathway; other site 472759001136 Binuclear center (active site) [active] 472759001137 K-pathway; other site 472759001138 Putative proton exit pathway; other site 472759001139 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 472759001140 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 472759001141 Cu(I) binding site [ion binding]; other site 472759001142 Predicted transcriptional regulator [Transcription]; Region: COG1959 472759001143 Transcriptional regulator; Region: Rrf2; cl17282 472759001144 5-oxoprolinase; Region: PLN02666 472759001145 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 472759001146 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 472759001147 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 472759001148 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 472759001149 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 472759001150 Probable transposase; Region: OrfB_IS605; pfam01385 472759001151 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 472759001152 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 472759001153 IHF dimer interface [polypeptide binding]; other site 472759001154 IHF - DNA interface [nucleotide binding]; other site 472759001155 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 472759001156 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 472759001157 metal binding site [ion binding]; metal-binding site 472759001158 active site 472759001159 I-site; other site 472759001160 Transposase, Mutator family; Region: Transposase_mut; pfam00872 472759001161 MULE transposase domain; Region: MULE; pfam10551 472759001162 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 472759001163 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 472759001164 MerR family regulatory protein; Region: MerR; pfam00376 472759001165 DNA binding residues [nucleotide binding] 472759001166 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 472759001167 catalytic residues [active] 472759001168 catalytic nucleophile [active] 472759001169 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 472759001170 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 472759001171 Probable transposase; Region: OrfB_IS605; pfam01385 472759001172 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 472759001173 hypothetical protein; Provisional; Region: PRK04286 472759001174 Methyltransferase domain; Region: Methyltransf_23; pfam13489 472759001175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759001176 S-adenosylmethionine binding site [chemical binding]; other site 472759001177 ribonuclease R; Region: RNase_R; TIGR02063 472759001178 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 472759001179 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 472759001180 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 472759001181 RNB domain; Region: RNB; pfam00773 472759001182 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 472759001183 RNA binding site [nucleotide binding]; other site 472759001184 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 472759001185 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 472759001186 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 472759001187 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 472759001188 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 472759001189 type II secretion system protein E; Region: type_II_gspE; TIGR02533 472759001190 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 472759001191 Walker A motif; other site 472759001192 ATP binding site [chemical binding]; other site 472759001193 Walker B motif; other site 472759001194 type II secretion system protein F; Region: GspF; TIGR02120 472759001195 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 472759001196 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 472759001197 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 472759001198 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 472759001199 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 472759001200 Type II transport protein GspH; Region: GspH; pfam12019 472759001201 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 472759001202 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 472759001203 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 472759001204 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 472759001205 putative ADP-binding pocket [chemical binding]; other site 472759001206 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 472759001207 putative hydrophobic ligand binding site [chemical binding]; other site 472759001208 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 472759001209 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 472759001210 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 472759001211 PAS domain S-box; Region: sensory_box; TIGR00229 472759001212 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 472759001213 putative active site [active] 472759001214 heme pocket [chemical binding]; other site 472759001215 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 472759001216 PAS domain; Region: PAS_9; pfam13426 472759001217 putative active site [active] 472759001218 heme pocket [chemical binding]; other site 472759001219 PAS domain S-box; Region: sensory_box; TIGR00229 472759001220 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 472759001221 putative active site [active] 472759001222 heme pocket [chemical binding]; other site 472759001223 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 472759001224 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 472759001225 oligopeptidase A; Provisional; Region: PRK10911 472759001226 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 472759001227 active site 472759001228 Zn binding site [ion binding]; other site 472759001229 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 472759001230 putative catalytic site [active] 472759001231 putative phosphate binding site [ion binding]; other site 472759001232 active site 472759001233 metal binding site A [ion binding]; metal-binding site 472759001234 DNA binding site [nucleotide binding] 472759001235 putative AP binding site [nucleotide binding]; other site 472759001236 putative metal binding site B [ion binding]; other site 472759001237 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 472759001238 TPR motif; other site 472759001239 binding surface 472759001240 Tetratricopeptide repeat; Region: TPR_12; pfam13424 472759001241 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 472759001242 binding surface 472759001243 TPR motif; other site 472759001244 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 472759001245 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 472759001246 PilZ domain; Region: PilZ; pfam07238 472759001247 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 472759001248 Alkaline and neutral invertase; Region: Glyco_hydro_100; cl17340 472759001249 HAD-superfamily subfamily IIA hydrolase, TIGR01458; Region: HAD-SF-IIA-hyp3 472759001250 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 472759001251 active site 472759001252 motif I; other site 472759001253 motif II; other site 472759001254 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 472759001255 Protein of unknown function (DUF330); Region: DUF330; cl01135 472759001256 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 472759001257 mce related protein; Region: MCE; pfam02470 472759001258 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 472759001259 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 472759001260 Walker A/P-loop; other site 472759001261 ATP binding site [chemical binding]; other site 472759001262 Q-loop/lid; other site 472759001263 ABC transporter signature motif; other site 472759001264 Walker B; other site 472759001265 D-loop; other site 472759001266 H-loop/switch region; other site 472759001267 STAS domain; Region: STAS_2; pfam13466 472759001268 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 472759001269 Permease; Region: Permease; pfam02405 472759001270 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 472759001271 FAD binding domain; Region: FAD_binding_4; pfam01565 472759001272 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 472759001273 outer membrane lipoprotein; Provisional; Region: PRK11023 472759001274 BON domain; Region: BON; pfam04972 472759001275 BON domain; Region: BON; pfam04972 472759001276 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 472759001277 dimer interface [polypeptide binding]; other site 472759001278 active site 472759001279 hypothetical protein; Reviewed; Region: PRK12497 472759001280 LppC putative lipoprotein; Region: LppC; pfam04348 472759001281 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 472759001282 putative ligand binding site [chemical binding]; other site 472759001283 Predicted methyltransferases [General function prediction only]; Region: COG0313 472759001284 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 472759001285 putative SAM binding site [chemical binding]; other site 472759001286 putative homodimer interface [polypeptide binding]; other site 472759001287 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 472759001288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 472759001289 ATP binding site [chemical binding]; other site 472759001290 G-X-G motif; other site 472759001291 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 472759001292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 472759001293 active site 472759001294 phosphorylation site [posttranslational modification] 472759001295 intermolecular recognition site; other site 472759001296 dimerization interface [polypeptide binding]; other site 472759001297 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 472759001298 DNA binding site [nucleotide binding] 472759001299 Predicted membrane protein [Function unknown]; Region: COG3212 472759001300 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 472759001301 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 472759001302 Cation efflux family; Region: Cation_efflux; cl00316 472759001303 cell division protein MraZ; Reviewed; Region: PRK00326 472759001304 MraZ protein; Region: MraZ; pfam02381 472759001305 MraZ protein; Region: MraZ; pfam02381 472759001306 MraW methylase family; Region: Methyltransf_5; cl17771 472759001307 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 472759001308 Cell division protein FtsL; Region: FtsL; pfam04999 472759001309 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 472759001310 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 472759001311 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 472759001312 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 472759001313 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 472759001314 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 472759001315 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 472759001316 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 472759001317 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 472759001318 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 472759001319 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 472759001320 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 472759001321 Mg++ binding site [ion binding]; other site 472759001322 putative catalytic motif [active] 472759001323 putative substrate binding site [chemical binding]; other site 472759001324 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 472759001325 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 472759001326 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 472759001327 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 472759001328 cell division protein FtsW; Region: ftsW; TIGR02614 472759001329 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 472759001330 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 472759001331 active site 472759001332 homodimer interface [polypeptide binding]; other site 472759001333 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 472759001334 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 472759001335 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 472759001336 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 472759001337 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 472759001338 FAD binding domain; Region: FAD_binding_4; pfam01565 472759001339 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 472759001340 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 472759001341 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 472759001342 ATP-grasp domain; Region: ATP-grasp_4; cl17255 472759001343 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 472759001344 Cell division protein FtsQ; Region: FtsQ; pfam03799 472759001345 cell division protein FtsA; Region: ftsA; TIGR01174 472759001346 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 472759001347 nucleotide binding site [chemical binding]; other site 472759001348 Cell division protein FtsA; Region: FtsA; pfam14450 472759001349 cell division protein FtsZ; Validated; Region: PRK09330 472759001350 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 472759001351 nucleotide binding site [chemical binding]; other site 472759001352 SulA interaction site; other site 472759001353 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 472759001354 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 472759001355 Protein of unknown function (DUF721); Region: DUF721; pfam05258 472759001356 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 472759001357 Peptidase family M23; Region: Peptidase_M23; pfam01551 472759001358 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 472759001359 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 472759001360 SEC-C motif; Region: SEC-C; pfam02810 472759001361 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 472759001362 heterotetramer interface [polypeptide binding]; other site 472759001363 active site pocket [active] 472759001364 cleavage site 472759001365 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 472759001366 iron-sulfur cluster [ion binding]; other site 472759001367 [2Fe-2S] cluster binding site [ion binding]; other site 472759001368 Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose. KHK can also phosphorylate several other furanose sugars. It is found in higher eukaryotes...; Region: Ketohexokinase; cd01939 472759001369 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 472759001370 substrate binding site [chemical binding]; other site 472759001371 ATP binding site [chemical binding]; other site 472759001372 adenylate kinase; Reviewed; Region: adk; PRK00279 472759001373 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 472759001374 AMP-binding site [chemical binding]; other site 472759001375 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 472759001376 6-phosphofructokinase; Provisional; Region: PRK14072 472759001377 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 472759001378 active site 472759001379 ADP/pyrophosphate binding site [chemical binding]; other site 472759001380 dimerization interface [polypeptide binding]; other site 472759001381 allosteric effector site; other site 472759001382 fructose-1,6-bisphosphate binding site; other site 472759001383 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 472759001384 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 472759001385 tandem repeat interface [polypeptide binding]; other site 472759001386 oligomer interface [polypeptide binding]; other site 472759001387 active site residues [active] 472759001388 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 472759001389 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 472759001390 RNA binding surface [nucleotide binding]; other site 472759001391 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 472759001392 active site 472759001393 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 472759001394 PBP superfamily domain; Region: PBP_like_2; pfam12849 472759001395 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 472759001396 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 472759001397 Walker A/P-loop; other site 472759001398 ATP binding site [chemical binding]; other site 472759001399 Q-loop/lid; other site 472759001400 ABC transporter signature motif; other site 472759001401 Walker B; other site 472759001402 D-loop; other site 472759001403 H-loop/switch region; other site 472759001404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 472759001405 dimer interface [polypeptide binding]; other site 472759001406 conserved gate region; other site 472759001407 putative PBP binding loops; other site 472759001408 ABC-ATPase subunit interface; other site 472759001409 FlgN protein; Region: FlgN; pfam05130 472759001410 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 472759001411 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 472759001412 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 472759001413 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 472759001414 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 472759001415 trimer interface [polypeptide binding]; other site 472759001416 dimer interface [polypeptide binding]; other site 472759001417 putative active site [active] 472759001418 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 472759001419 MoaE interaction surface [polypeptide binding]; other site 472759001420 MoeB interaction surface [polypeptide binding]; other site 472759001421 thiocarboxylated glycine; other site 472759001422 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 472759001423 MoaE homodimer interface [polypeptide binding]; other site 472759001424 MoaD interaction [polypeptide binding]; other site 472759001425 active site residues [active] 472759001426 GAF domain; Region: GAF; cl17456 472759001427 PAS fold; Region: PAS_4; pfam08448 472759001428 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 472759001429 putative active site [active] 472759001430 heme pocket [chemical binding]; other site 472759001431 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 472759001432 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 472759001433 metal binding site [ion binding]; metal-binding site 472759001434 active site 472759001435 I-site; other site 472759001436 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 472759001437 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 472759001438 FAD binding site [chemical binding]; other site 472759001439 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 472759001440 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 472759001441 homotetramer interface [polypeptide binding]; other site 472759001442 ligand binding site [chemical binding]; other site 472759001443 catalytic site [active] 472759001444 NAD binding site [chemical binding]; other site 472759001445 S-adenosylmethionine synthetase; Validated; Region: PRK05250 472759001446 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 472759001447 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 472759001448 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 472759001449 Uncharacterized conserved protein [Function unknown]; Region: COG2835 472759001450 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 472759001451 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 472759001452 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 472759001453 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 472759001454 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 472759001455 Walker A/P-loop; other site 472759001456 ATP binding site [chemical binding]; other site 472759001457 Q-loop/lid; other site 472759001458 ABC transporter signature motif; other site 472759001459 Walker B; other site 472759001460 D-loop; other site 472759001461 H-loop/switch region; other site 472759001462 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 472759001463 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 472759001464 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 472759001465 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 472759001466 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 472759001467 Competence protein; Region: Competence; pfam03772 472759001468 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 472759001469 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 472759001470 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 472759001471 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 472759001472 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 472759001473 Walker A/P-loop; other site 472759001474 ATP binding site [chemical binding]; other site 472759001475 Q-loop/lid; other site 472759001476 ABC transporter signature motif; other site 472759001477 Walker B; other site 472759001478 D-loop; other site 472759001479 H-loop/switch region; other site 472759001480 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 472759001481 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 472759001482 FtsX-like permease family; Region: FtsX; pfam02687 472759001483 PilZ domain; Region: PilZ; pfam07238 472759001484 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 472759001485 tetramer (dimer of dimers) interface [polypeptide binding]; other site 472759001486 active site 472759001487 dimer interface [polypeptide binding]; other site 472759001488 threonine dehydratase; Reviewed; Region: PRK09224 472759001489 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 472759001490 tetramer interface [polypeptide binding]; other site 472759001491 pyridoxal 5'-phosphate binding site [chemical binding]; other site 472759001492 catalytic residue [active] 472759001493 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 472759001494 putative Ile/Val binding site [chemical binding]; other site 472759001495 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 472759001496 putative Ile/Val binding site [chemical binding]; other site 472759001497 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 472759001498 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 472759001499 HIGH motif; other site 472759001500 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 472759001501 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 472759001502 active site 472759001503 KMSKS motif; other site 472759001504 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 472759001505 tRNA binding surface [nucleotide binding]; other site 472759001506 Lipopolysaccharide-assembly; Region: LptE; cl01125 472759001507 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 472759001508 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 472759001509 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 472759001510 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 472759001511 putative catalytic cysteine [active] 472759001512 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 472759001513 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 472759001514 active site 472759001515 (T/H)XGH motif; other site 472759001516 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 472759001517 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 472759001518 Maf-like protein; Region: Maf; pfam02545 472759001519 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 472759001520 active site 472759001521 dimer interface [polypeptide binding]; other site 472759001522 ribonuclease G; Provisional; Region: PRK11712 472759001523 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 472759001524 homodimer interface [polypeptide binding]; other site 472759001525 oligonucleotide binding site [chemical binding]; other site 472759001526 TIGR02099 family protein; Region: TIGR02099 472759001527 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 472759001528 nitrilase; Region: PLN02798 472759001529 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 472759001530 putative active site [active] 472759001531 catalytic triad [active] 472759001532 dimer interface [polypeptide binding]; other site 472759001533 protease TldD; Provisional; Region: tldD; PRK10735 472759001534 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 472759001535 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 472759001536 Ligand Binding Site [chemical binding]; other site 472759001537 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 472759001538 CPxP motif; other site 472759001539 glutamine synthetase; Provisional; Region: glnA; PRK09469 472759001540 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 472759001541 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 472759001542 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 472759001543 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 472759001544 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 472759001545 DNA binding site [nucleotide binding] 472759001546 catalytic residue [active] 472759001547 H2TH interface [polypeptide binding]; other site 472759001548 putative catalytic residues [active] 472759001549 turnover-facilitating residue; other site 472759001550 intercalation triad [nucleotide binding]; other site 472759001551 8OG recognition residue [nucleotide binding]; other site 472759001552 putative reading head residues; other site 472759001553 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 472759001554 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 472759001555 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 472759001556 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 472759001557 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 472759001558 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 472759001559 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 472759001560 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 472759001561 Walker A/P-loop; other site 472759001562 ATP binding site [chemical binding]; other site 472759001563 Q-loop/lid; other site 472759001564 ABC transporter signature motif; other site 472759001565 Walker B; other site 472759001566 D-loop; other site 472759001567 H-loop/switch region; other site 472759001568 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 472759001569 nudix motif; other site 472759001570 Fatty acid desaturase; Region: FA_desaturase; pfam00487 472759001571 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 472759001572 putative di-iron ligands [ion binding]; other site 472759001573 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 472759001574 Transposase; Region: DDE_Tnp_ISL3; pfam01610 472759001575 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 472759001576 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 472759001577 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 472759001578 putative catalytic site [active] 472759001579 putative metal binding site [ion binding]; other site 472759001580 putative phosphate binding site [ion binding]; other site 472759001581 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 472759001582 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 472759001583 putative NAD(P) binding site [chemical binding]; other site 472759001584 active site 472759001585 putative substrate binding site [chemical binding]; other site 472759001586 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 472759001587 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 472759001588 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 472759001589 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 472759001590 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 472759001591 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 472759001592 rod shape-determining protein MreB; Provisional; Region: PRK13927 472759001593 MreB and similar proteins; Region: MreB_like; cd10225 472759001594 nucleotide binding site [chemical binding]; other site 472759001595 Mg binding site [ion binding]; other site 472759001596 putative protofilament interaction site [polypeptide binding]; other site 472759001597 RodZ interaction site [polypeptide binding]; other site 472759001598 rod shape-determining protein MreC; Provisional; Region: PRK13922 472759001599 rod shape-determining protein MreC; Region: MreC; pfam04085 472759001600 rod shape-determining protein MreD; Region: MreD; cl01087 472759001601 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 472759001602 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 472759001603 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 472759001604 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 472759001605 Transglycosylase SLT domain; Region: SLT_2; pfam13406 472759001606 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 472759001607 N-acetyl-D-glucosamine binding site [chemical binding]; other site 472759001608 catalytic residue [active] 472759001609 rare lipoprotein A; Region: rlpA; TIGR00413 472759001610 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 472759001611 Sporulation related domain; Region: SPOR; pfam05036 472759001612 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 472759001613 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 472759001614 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 472759001615 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 472759001616 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 472759001617 homodimer interface [polypeptide binding]; other site 472759001618 substrate-cofactor binding pocket; other site 472759001619 pyridoxal 5'-phosphate binding site [chemical binding]; other site 472759001620 catalytic residue [active] 472759001621 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 472759001622 lipoyl synthase; Provisional; Region: PRK05481 472759001623 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 472759001624 FeS/SAM binding site; other site 472759001625 citrate synthase; Provisional; Region: PRK14036 472759001626 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_1; cd06112 472759001627 dimer interface [polypeptide binding]; other site 472759001628 active site 472759001629 citrylCoA binding site [chemical binding]; other site 472759001630 oxalacetate/citrate binding site [chemical binding]; other site 472759001631 coenzyme A binding site [chemical binding]; other site 472759001632 catalytic triad [active] 472759001633 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 472759001634 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 472759001635 FeS/SAM binding site; other site 472759001636 elongation factor P; Validated; Region: PRK00529 472759001637 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 472759001638 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 472759001639 RNA binding site [nucleotide binding]; other site 472759001640 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 472759001641 RNA binding site [nucleotide binding]; other site 472759001642 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 472759001643 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 472759001644 motif 1; other site 472759001645 dimer interface [polypeptide binding]; other site 472759001646 active site 472759001647 motif 2; other site 472759001648 motif 3; other site 472759001649 DctM-like transporters; Region: DctM; pfam06808 472759001650 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 472759001651 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 472759001652 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 472759001653 putative active site [active] 472759001654 dimerization interface [polypeptide binding]; other site 472759001655 putative tRNAtyr binding site [nucleotide binding]; other site 472759001656 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 472759001657 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 472759001658 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 472759001659 CoA-ligase; Region: Ligase_CoA; pfam00549 472759001660 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 472759001661 CoA binding domain; Region: CoA_binding; smart00881 472759001662 CoA-ligase; Region: Ligase_CoA; pfam00549 472759001663 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 472759001664 Nitrogen regulatory protein P-II; Region: P-II; smart00938 472759001665 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 472759001666 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 472759001667 binding surface 472759001668 TPR motif; other site 472759001669 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 472759001670 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 472759001671 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 472759001672 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 472759001673 active site 472759001674 dimerization interface [polypeptide binding]; other site 472759001675 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 472759001676 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 472759001677 G1 box; other site 472759001678 putative GEF interaction site [polypeptide binding]; other site 472759001679 GTP/Mg2+ binding site [chemical binding]; other site 472759001680 Switch I region; other site 472759001681 G2 box; other site 472759001682 G3 box; other site 472759001683 Switch II region; other site 472759001684 G4 box; other site 472759001685 G5 box; other site 472759001686 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 472759001687 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 472759001688 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 472759001689 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 472759001690 dimer interface [polypeptide binding]; other site 472759001691 phosphorylation site [posttranslational modification] 472759001692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 472759001693 ATP binding site [chemical binding]; other site 472759001694 Mg2+ binding site [ion binding]; other site 472759001695 G-X-G motif; other site 472759001696 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 472759001697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 472759001698 active site 472759001699 phosphorylation site [posttranslational modification] 472759001700 intermolecular recognition site; other site 472759001701 dimerization interface [polypeptide binding]; other site 472759001702 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759001703 Walker A motif; other site 472759001704 ATP binding site [chemical binding]; other site 472759001705 Walker B motif; other site 472759001706 arginine finger; other site 472759001707 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 472759001708 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 472759001709 Transposase; Region: HTH_Tnp_1; pfam01527 472759001710 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 472759001711 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 472759001712 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 472759001713 putative active site [active] 472759001714 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 472759001715 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 472759001716 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 472759001717 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 472759001718 non-specific DNA binding site [nucleotide binding]; other site 472759001719 salt bridge; other site 472759001720 sequence-specific DNA binding site [nucleotide binding]; other site 472759001721 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 472759001722 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 472759001723 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 472759001724 Pilin (bacterial filament); Region: Pilin; pfam00114 472759001725 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 472759001726 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 472759001727 Ligand binding site; other site 472759001728 Putative Catalytic site; other site 472759001729 DXD motif; other site 472759001730 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 472759001731 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 472759001732 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 472759001733 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 472759001734 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 472759001735 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 472759001736 UDP-galactopyranose mutase; Region: GLF; pfam03275 472759001737 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 472759001738 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 472759001739 active site 472759001740 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 472759001741 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 472759001742 active site 472759001743 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 472759001744 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 472759001745 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 472759001746 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 472759001747 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 472759001748 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 472759001749 YcfA-like protein; Region: YcfA; cl00752 472759001750 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 472759001751 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 472759001752 active site 472759001753 NTP binding site [chemical binding]; other site 472759001754 metal binding triad [ion binding]; metal-binding site 472759001755 antibiotic binding site [chemical binding]; other site 472759001756 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 472759001757 MerR family regulatory protein; Region: MerR; pfam00376 472759001758 DNA binding residues [nucleotide binding] 472759001759 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 472759001760 catalytic residues [active] 472759001761 catalytic nucleophile [active] 472759001762 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 472759001763 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 472759001764 Probable transposase; Region: OrfB_IS605; pfam01385 472759001765 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 472759001766 Transposase, Mutator family; Region: Transposase_mut; pfam00872 472759001767 MULE transposase domain; Region: MULE; pfam10551 472759001768 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 472759001769 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 472759001770 Predicted membrane protein [Function unknown]; Region: COG1238 472759001771 Predicted membrane protein [Function unknown]; Region: COG3212 472759001772 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 472759001773 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 472759001774 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 472759001775 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 472759001776 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 472759001777 ligand binding site [chemical binding]; other site 472759001778 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 472759001779 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 472759001780 N-acetyl-D-glucosamine binding site [chemical binding]; other site 472759001781 catalytic residue [active] 472759001782 putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073 472759001783 MT-A70; Region: MT-A70; cl01947 472759001784 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 472759001785 dimer interface [polypeptide binding]; other site 472759001786 putative radical transfer pathway; other site 472759001787 diiron center [ion binding]; other site 472759001788 tyrosyl radical; other site 472759001789 ATP cone domain; Region: ATP-cone; pfam03477 472759001790 ATP cone domain; Region: ATP-cone; pfam03477 472759001791 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 472759001792 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 472759001793 protein-splicing catalytic site; other site 472759001794 thioester formation/cholesterol transfer; other site 472759001795 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 472759001796 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 472759001797 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 472759001798 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 472759001799 protein-splicing catalytic site; other site 472759001800 thioester formation/cholesterol transfer; other site 472759001801 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 472759001802 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 472759001803 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 472759001804 catalytic triad [active] 472759001805 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 472759001806 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 472759001807 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 472759001808 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 472759001809 dihydrodipicolinate synthase; Region: dapA; TIGR00674 472759001810 dimer interface [polypeptide binding]; other site 472759001811 active site 472759001812 catalytic residue [active] 472759001813 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 472759001814 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 472759001815 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 472759001816 ATP binding site [chemical binding]; other site 472759001817 active site 472759001818 substrate binding site [chemical binding]; other site 472759001819 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 472759001820 active site 472759001821 substrate binding pocket [chemical binding]; other site 472759001822 dimer interface [polypeptide binding]; other site 472759001823 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 472759001824 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 472759001825 PYR/PP interface [polypeptide binding]; other site 472759001826 dimer interface [polypeptide binding]; other site 472759001827 TPP binding site [chemical binding]; other site 472759001828 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 472759001829 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 472759001830 TPP-binding site [chemical binding]; other site 472759001831 dimer interface [polypeptide binding]; other site 472759001832 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 472759001833 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 472759001834 putative valine binding site [chemical binding]; other site 472759001835 dimer interface [polypeptide binding]; other site 472759001836 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 472759001837 ketol-acid reductoisomerase; Provisional; Region: PRK05479 472759001838 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 472759001839 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 472759001840 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 472759001841 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 472759001842 2-isopropylmalate synthase; Validated; Region: PRK00915 472759001843 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 472759001844 active site 472759001845 catalytic residues [active] 472759001846 metal binding site [ion binding]; metal-binding site 472759001847 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 472759001848 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 472759001849 Fe-S cluster binding site [ion binding]; other site 472759001850 active site 472759001851 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 472759001852 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 472759001853 Coenzyme A binding pocket [chemical binding]; other site 472759001854 Predicted membrane protein [Function unknown]; Region: COG3174 472759001855 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 472759001856 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 472759001857 dimer interface [polypeptide binding]; other site 472759001858 ADP-ribose binding site [chemical binding]; other site 472759001859 active site 472759001860 nudix motif; other site 472759001861 metal binding site [ion binding]; metal-binding site 472759001862 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 472759001863 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 472759001864 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 472759001865 Domain of unknown function (DUF3337); Region: DUF3337; pfam11816 472759001866 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 472759001867 AAA ATPase domain; Region: AAA_16; pfam13191 472759001868 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 472759001869 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 472759001870 metal ion-dependent adhesion site (MIDAS); other site 472759001871 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 472759001872 SpoVR like protein; Region: SpoVR; pfam04293 472759001873 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 472759001874 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 472759001875 Multicopper oxidase; Region: Cu-oxidase; pfam00394 472759001876 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 472759001877 FOG: CBS domain [General function prediction only]; Region: COG0517 472759001878 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 472759001879 phosphoserine phosphatase SerB; Region: serB; TIGR00338 472759001880 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 472759001881 motif II; other site 472759001882 Ammonia monooxygenase/methane monooxygenase, subunit C; Region: AmoC; pfam04896 472759001883 Ammonia monooxygenase; Region: AMO; pfam02461 472759001884 methane monooxygenase/ammonia monooxygenase, subunit B; Region: CH4_NH3mon_ox_B; TIGR03079 472759001885 Monooxygenase subunit B protein; Region: Monooxygenase_B; pfam04744 472759001886 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 472759001887 active site 472759001888 ribulose/triose binding site [chemical binding]; other site 472759001889 phosphate binding site [ion binding]; other site 472759001890 substrate (anthranilate) binding pocket [chemical binding]; other site 472759001891 product (indole) binding pocket [chemical binding]; other site 472759001892 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 472759001893 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 472759001894 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 472759001895 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 472759001896 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 472759001897 glutamine binding [chemical binding]; other site 472759001898 catalytic triad [active] 472759001899 anthranilate synthase component I; Provisional; Region: PRK13565 472759001900 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 472759001901 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 472759001902 phosphoglycolate phosphatase; Provisional; Region: PRK13222 472759001903 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 472759001904 motif II; other site 472759001905 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 472759001906 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 472759001907 substrate binding site [chemical binding]; other site 472759001908 hexamer interface [polypeptide binding]; other site 472759001909 metal binding site [ion binding]; metal-binding site 472759001910 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 472759001911 Transcriptional regulator; Region: Rrf2; pfam02082 472759001912 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 472759001913 putative ABC transporter; Region: ycf24; CHL00085 472759001914 FeS assembly ATPase SufC; Region: sufC; TIGR01978 472759001915 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 472759001916 Walker A/P-loop; other site 472759001917 ATP binding site [chemical binding]; other site 472759001918 Q-loop/lid; other site 472759001919 ABC transporter signature motif; other site 472759001920 Walker B; other site 472759001921 D-loop; other site 472759001922 H-loop/switch region; other site 472759001923 FeS assembly protein SufD; Region: sufD; TIGR01981 472759001924 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 472759001925 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 472759001926 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 472759001927 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 472759001928 catalytic residue [active] 472759001929 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 472759001930 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 472759001931 trimerization site [polypeptide binding]; other site 472759001932 active site 472759001933 Domain of unknown function DUF59; Region: DUF59; cl00941 472759001934 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 472759001935 transcriptional activator RfaH; Region: RfaH; TIGR01955 472759001936 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 472759001937 heterodimer interface [polypeptide binding]; other site 472759001938 homodimer interface [polypeptide binding]; other site 472759001939 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 472759001940 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 472759001941 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 472759001942 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 472759001943 ligand-binding site [chemical binding]; other site 472759001944 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 472759001945 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 472759001946 Beta-Casp domain; Region: Beta-Casp; smart01027 472759001947 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 472759001948 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 472759001949 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 472759001950 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 472759001951 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 472759001952 putative ADP-binding pocket [chemical binding]; other site 472759001953 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 472759001954 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 472759001955 putative ADP-binding pocket [chemical binding]; other site 472759001956 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 472759001957 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 472759001958 active site 472759001959 dimer interface [polypeptide binding]; other site 472759001960 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 472759001961 Ligand Binding Site [chemical binding]; other site 472759001962 Molecular Tunnel; other site 472759001963 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 472759001964 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 472759001965 putative ADP-binding pocket [chemical binding]; other site 472759001966 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 472759001967 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 472759001968 Mg++ binding site [ion binding]; other site 472759001969 putative catalytic motif [active] 472759001970 putative substrate binding site [chemical binding]; other site 472759001971 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 472759001972 IHF - DNA interface [nucleotide binding]; other site 472759001973 IHF dimer interface [polypeptide binding]; other site 472759001974 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 472759001975 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 472759001976 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 472759001977 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 472759001978 Iron-sulfur protein interface; other site 472759001979 proximal quinone binding site [chemical binding]; other site 472759001980 SdhD (CybS) interface [polypeptide binding]; other site 472759001981 proximal heme binding site [chemical binding]; other site 472759001982 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 472759001983 SdhC subunit interface [polypeptide binding]; other site 472759001984 proximal heme binding site [chemical binding]; other site 472759001985 cardiolipin binding site; other site 472759001986 Iron-sulfur protein interface; other site 472759001987 proximal quinone binding site [chemical binding]; other site 472759001988 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 472759001989 L-aspartate oxidase; Provisional; Region: PRK06175 472759001990 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 472759001991 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 472759001992 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 472759001993 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 472759001994 L-aspartate oxidase; Provisional; Region: PRK09077 472759001995 L-aspartate oxidase; Provisional; Region: PRK06175 472759001996 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 472759001997 RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923 472759001998 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 472759001999 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 472759002000 DNA binding residues [nucleotide binding] 472759002001 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 472759002002 anti-sigma E factor; Provisional; Region: rseB; PRK09455 472759002003 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 472759002004 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 472759002005 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 472759002006 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 472759002007 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 472759002008 protein binding site [polypeptide binding]; other site 472759002009 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 472759002010 protein binding site [polypeptide binding]; other site 472759002011 GTP-binding protein LepA; Provisional; Region: PRK05433 472759002012 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 472759002013 G1 box; other site 472759002014 putative GEF interaction site [polypeptide binding]; other site 472759002015 GTP/Mg2+ binding site [chemical binding]; other site 472759002016 Switch I region; other site 472759002017 G2 box; other site 472759002018 G3 box; other site 472759002019 Switch II region; other site 472759002020 G4 box; other site 472759002021 G5 box; other site 472759002022 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 472759002023 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 472759002024 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 472759002025 signal peptidase I; Provisional; Region: PRK10861 472759002026 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 472759002027 Catalytic site [active] 472759002028 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 472759002029 ribonuclease III; Reviewed; Region: rnc; PRK00102 472759002030 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 472759002031 dimerization interface [polypeptide binding]; other site 472759002032 active site 472759002033 metal binding site [ion binding]; metal-binding site 472759002034 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 472759002035 dsRNA binding site [nucleotide binding]; other site 472759002036 GTPase Era; Reviewed; Region: era; PRK00089 472759002037 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 472759002038 G1 box; other site 472759002039 GTP/Mg2+ binding site [chemical binding]; other site 472759002040 Switch I region; other site 472759002041 G2 box; other site 472759002042 Switch II region; other site 472759002043 G3 box; other site 472759002044 G4 box; other site 472759002045 G5 box; other site 472759002046 KH domain; Region: KH_2; pfam07650 472759002047 G-X-X-G motif; other site 472759002048 HDOD domain; Region: HDOD; pfam08668 472759002049 aminotransferase; Validated; Region: PRK08175 472759002050 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 472759002051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 472759002052 homodimer interface [polypeptide binding]; other site 472759002053 catalytic residue [active] 472759002054 homoserine dehydrogenase; Provisional; Region: PRK06349 472759002055 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 472759002056 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 472759002057 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 472759002058 threonine synthase; Reviewed; Region: PRK06721 472759002059 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 472759002060 homodimer interface [polypeptide binding]; other site 472759002061 pyridoxal 5'-phosphate binding site [chemical binding]; other site 472759002062 catalytic residue [active] 472759002063 Response regulator receiver domain; Region: Response_reg; pfam00072 472759002064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 472759002065 active site 472759002066 phosphorylation site [posttranslational modification] 472759002067 intermolecular recognition site; other site 472759002068 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 472759002069 GAF domain; Region: GAF; pfam01590 472759002070 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 472759002071 dimer interface [polypeptide binding]; other site 472759002072 phosphorylation site [posttranslational modification] 472759002073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 472759002074 ATP binding site [chemical binding]; other site 472759002075 Mg2+ binding site [ion binding]; other site 472759002076 G-X-G motif; other site 472759002077 Response regulator receiver domain; Region: Response_reg; pfam00072 472759002078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 472759002079 active site 472759002080 phosphorylation site [posttranslational modification] 472759002081 intermolecular recognition site; other site 472759002082 dimerization interface [polypeptide binding]; other site 472759002083 Nitrate and nitrite sensing; Region: NIT; pfam08376 472759002084 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 472759002085 HAMP domain; Region: HAMP; pfam00672 472759002086 dimerization interface [polypeptide binding]; other site 472759002087 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 472759002088 dimer interface [polypeptide binding]; other site 472759002089 phosphorylation site [posttranslational modification] 472759002090 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 472759002091 ATP binding site [chemical binding]; other site 472759002092 Mg2+ binding site [ion binding]; other site 472759002093 G-X-G motif; other site 472759002094 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 472759002095 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 472759002096 putative active site; other site 472759002097 catalytic triad [active] 472759002098 putative dimer interface [polypeptide binding]; other site 472759002099 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 472759002100 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 472759002101 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 472759002102 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 472759002103 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 472759002104 putative active site [active] 472759002105 putative metal binding site [ion binding]; other site 472759002106 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 472759002107 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 472759002108 putative active site [active] 472759002109 heme pocket [chemical binding]; other site 472759002110 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 472759002111 dimer interface [polypeptide binding]; other site 472759002112 phosphorylation site [posttranslational modification] 472759002113 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 472759002114 ATP binding site [chemical binding]; other site 472759002115 Mg2+ binding site [ion binding]; other site 472759002116 G-X-G motif; other site 472759002117 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 472759002118 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 472759002119 active site 472759002120 phosphorylation site [posttranslational modification] 472759002121 intermolecular recognition site; other site 472759002122 dimerization interface [polypeptide binding]; other site 472759002123 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 472759002124 DNA binding residues [nucleotide binding] 472759002125 dimerization interface [polypeptide binding]; other site 472759002126 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 472759002127 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 472759002128 Probable transposase; Region: OrfB_IS605; pfam01385 472759002129 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 472759002130 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 472759002131 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 472759002132 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 472759002133 FeS/SAM binding site; other site 472759002134 HemN C-terminal domain; Region: HemN_C; pfam06969 472759002135 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 472759002136 active site 472759002137 dimerization interface [polypeptide binding]; other site 472759002138 ribonuclease PH; Reviewed; Region: rph; PRK00173 472759002139 Ribonuclease PH; Region: RNase_PH_bact; cd11362 472759002140 hexamer interface [polypeptide binding]; other site 472759002141 active site 472759002142 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 472759002143 intersubunit interface [polypeptide binding]; other site 472759002144 active site 472759002145 Zn2+ binding site [ion binding]; other site 472759002146 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 472759002147 Cupin domain; Region: Cupin_2; cl17218 472759002148 Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229 472759002149 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 472759002150 motif I; other site 472759002151 motif II; other site 472759002152 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 472759002153 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 472759002154 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 472759002155 putative phosphoketolase; Provisional; Region: PRK05261 472759002156 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 472759002157 TPP-binding site; other site 472759002158 XFP C-terminal domain; Region: XFP_C; pfam09363 472759002159 Probable transposase; Region: OrfB_IS605; pfam01385 472759002160 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 472759002161 hypothetical protein; Provisional; Region: PRK11820 472759002162 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 472759002163 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 472759002164 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 472759002165 non-specific DNA binding site [nucleotide binding]; other site 472759002166 salt bridge; other site 472759002167 sequence-specific DNA binding site [nucleotide binding]; other site 472759002168 Domain of unknown function (DUF955); Region: DUF955; pfam06114 472759002169 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 472759002170 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 472759002171 HsdM N-terminal domain; Region: HsdM_N; pfam12161 472759002172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759002173 S-adenosylmethionine binding site [chemical binding]; other site 472759002174 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 472759002175 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 472759002176 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 472759002177 Divergent AAA domain; Region: AAA_4; pfam04326 472759002178 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 472759002179 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 472759002180 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 472759002181 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 472759002182 ATP binding site [chemical binding]; other site 472759002183 putative Mg++ binding site [ion binding]; other site 472759002184 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 472759002185 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 472759002186 catalytic site [active] 472759002187 G-X2-G-X-G-K; other site 472759002188 RRXRR protein; Region: RRXRR; pfam14239 472759002189 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 472759002190 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 472759002191 active site 472759002192 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 472759002193 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 472759002194 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 472759002195 Zn2+ binding site [ion binding]; other site 472759002196 Mg2+ binding site [ion binding]; other site 472759002197 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 472759002198 synthetase active site [active] 472759002199 NTP binding site [chemical binding]; other site 472759002200 metal binding site [ion binding]; metal-binding site 472759002201 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 472759002202 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 472759002203 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 472759002204 homotrimer interaction site [polypeptide binding]; other site 472759002205 putative active site [active] 472759002206 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 472759002207 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 472759002208 ssDNA binding site; other site 472759002209 generic binding surface II; other site 472759002210 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 472759002211 ATP binding site [chemical binding]; other site 472759002212 putative Mg++ binding site [ion binding]; other site 472759002213 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 472759002214 nucleotide binding region [chemical binding]; other site 472759002215 ATP-binding site [chemical binding]; other site 472759002216 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 472759002217 UbiA prenyltransferase family; Region: UbiA; pfam01040 472759002218 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 472759002219 Staphylococcal nuclease homologues; Region: SNc; smart00318 472759002220 Catalytic site; other site 472759002221 Staphylococcal nuclease homologue; Region: SNase; pfam00565 472759002222 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 472759002223 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 472759002224 active site 472759002225 biotin synthase; Provisional; Region: PRK15108 472759002226 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 472759002227 FeS/SAM binding site; other site 472759002228 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 472759002229 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 472759002230 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 472759002231 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 472759002232 catalytic residue [active] 472759002233 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 472759002234 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 472759002235 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 472759002236 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759002237 S-adenosylmethionine binding site [chemical binding]; other site 472759002238 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 472759002239 AAA domain; Region: AAA_26; pfam13500 472759002240 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 472759002241 NAD synthetase; Reviewed; Region: nadE; PRK02628 472759002242 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 472759002243 multimer interface [polypeptide binding]; other site 472759002244 active site 472759002245 catalytic triad [active] 472759002246 protein interface 1 [polypeptide binding]; other site 472759002247 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 472759002248 homodimer interface [polypeptide binding]; other site 472759002249 NAD binding pocket [chemical binding]; other site 472759002250 ATP binding pocket [chemical binding]; other site 472759002251 Mg binding site [ion binding]; other site 472759002252 active-site loop [active] 472759002253 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 472759002254 Helix-turn-helix domain; Region: HTH_37; pfam13744 472759002255 Uncharacterized conserved protein [Function unknown]; Region: COG3189 472759002256 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 472759002257 active site 472759002258 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 472759002259 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 472759002260 ATP synthase (C/AC39) subunit; Region: vATP-synt_AC39; pfam01992 472759002261 V-type ATP synthase subunit I; Validated; Region: PRK05771 472759002262 ATP synthase subunit C; Region: ATP-synt_C; cl00466 472759002263 V-type ATP synthase subunit E; Provisional; Region: PRK03963; cl17074 472759002264 V-type ATP synthase subunit A; Provisional; Region: PRK04192 472759002265 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 472759002266 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 472759002267 Walker A motif/ATP binding site; other site 472759002268 Walker B motif; other site 472759002269 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 472759002270 V-type ATP synthase subunit B; Provisional; Region: PRK04196 472759002271 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 472759002272 Walker A motif homologous position; other site 472759002273 Walker B motif; other site 472759002274 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 472759002275 ATP synthase subunit D; Region: ATP-synt_D; pfam01813 472759002276 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 472759002277 Uncharacterized conserved protein [Function unknown]; Region: COG5464 472759002278 Helix-turn-helix domain; Region: HTH_17; pfam12728 472759002279 Restriction endonuclease; Region: Mrr_cat; pfam04471 472759002280 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 472759002281 BON domain; Region: BON; pfam04972 472759002282 BON domain; Region: BON; pfam04972 472759002283 BON domain; Region: BON; pfam04972 472759002284 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 472759002285 IHF dimer interface [polypeptide binding]; other site 472759002286 IHF - DNA interface [nucleotide binding]; other site 472759002287 periplasmic folding chaperone; Provisional; Region: PRK10788 472759002288 SurA N-terminal domain; Region: SurA_N_3; cl07813 472759002289 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 472759002290 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 472759002291 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 472759002292 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 472759002293 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 472759002294 NAD binding site [chemical binding]; other site 472759002295 homotetramer interface [polypeptide binding]; other site 472759002296 homodimer interface [polypeptide binding]; other site 472759002297 substrate binding site [chemical binding]; other site 472759002298 active site 472759002299 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505 472759002300 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 472759002301 YcfA-like protein; Region: YcfA; cl00752 472759002302 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 472759002303 dimer interface [polypeptide binding]; other site 472759002304 putative tRNA-binding site [nucleotide binding]; other site 472759002305 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 472759002306 putative active site [active] 472759002307 homotetrameric interface [polypeptide binding]; other site 472759002308 metal binding site [ion binding]; metal-binding site 472759002309 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 472759002310 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cl00208 472759002311 CAS motifs; other site 472759002312 active site 472759002313 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 472759002314 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 472759002315 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 472759002316 ABC transporter; Region: ABC_tran_2; pfam12848 472759002317 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 472759002318 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB2; cd01048 472759002319 diiron binding motif [ion binding]; other site 472759002320 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 472759002321 active site flap/lid [active] 472759002322 nucleophilic elbow; other site 472759002323 catalytic triad [active] 472759002324 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 472759002325 Predicted transcriptional regulator [Transcription]; Region: COG3905 472759002326 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 472759002327 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 472759002328 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 472759002329 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 472759002330 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 472759002331 HlyD family secretion protein; Region: HlyD_3; pfam13437 472759002332 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 472759002333 metal ion-dependent adhesion site (MIDAS); other site 472759002334 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 472759002335 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 472759002336 phosphopeptide binding site; other site 472759002337 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 472759002338 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 472759002339 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 472759002340 active site 472759002341 ATP binding site [chemical binding]; other site 472759002342 substrate binding site [chemical binding]; other site 472759002343 activation loop (A-loop); other site 472759002344 YwiC-like protein; Region: YwiC; pfam14256 472759002345 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 472759002346 Sel1-like repeats; Region: SEL1; smart00671 472759002347 Sel1-like repeats; Region: SEL1; smart00671 472759002348 Caspase domain; Region: Peptidase_C14; pfam00656 472759002349 Autotransporter beta-domain; Region: Autotransporter; pfam03797 472759002350 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 472759002351 active site 472759002352 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 472759002353 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759002354 Walker A motif; other site 472759002355 ATP binding site [chemical binding]; other site 472759002356 Walker B motif; other site 472759002357 arginine finger; other site 472759002358 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 472759002359 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 472759002360 ligand binding site [chemical binding]; other site 472759002361 flexible hinge region; other site 472759002362 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 472759002363 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 472759002364 ligand binding site [chemical binding]; other site 472759002365 flexible hinge region; other site 472759002366 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 472759002367 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 472759002368 putative active site [active] 472759002369 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 472759002370 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 472759002371 Walker A/P-loop; other site 472759002372 ATP binding site [chemical binding]; other site 472759002373 Q-loop/lid; other site 472759002374 ABC transporter signature motif; other site 472759002375 Walker B; other site 472759002376 D-loop; other site 472759002377 H-loop/switch region; other site 472759002378 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 472759002379 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 472759002380 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 472759002381 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 472759002382 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 472759002383 HlyD family secretion protein; Region: HlyD_3; pfam13437 472759002384 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 472759002385 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 472759002386 phosphopeptide binding site; other site 472759002387 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 472759002388 phosphopeptide binding site; other site 472759002389 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 472759002390 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 472759002391 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 472759002392 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 472759002393 phosphopeptide binding site; other site 472759002394 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759002395 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 472759002396 Walker A motif; other site 472759002397 ATP binding site [chemical binding]; other site 472759002398 Walker B motif; other site 472759002399 arginine finger; other site 472759002400 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 472759002401 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 472759002402 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 472759002403 dimer interface [polypeptide binding]; other site 472759002404 conserved gate region; other site 472759002405 putative PBP binding loops; other site 472759002406 ABC-ATPase subunit interface; other site 472759002407 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 472759002408 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 472759002409 dimer interface [polypeptide binding]; other site 472759002410 conserved gate region; other site 472759002411 putative PBP binding loops; other site 472759002412 ABC-ATPase subunit interface; other site 472759002413 Ion transport protein; Region: Ion_trans; pfam00520 472759002414 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 472759002415 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 472759002416 Walker A/P-loop; other site 472759002417 ATP binding site [chemical binding]; other site 472759002418 Q-loop/lid; other site 472759002419 ABC transporter signature motif; other site 472759002420 Walker B; other site 472759002421 D-loop; other site 472759002422 H-loop/switch region; other site 472759002423 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 472759002424 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 472759002425 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 472759002426 Walker A/P-loop; other site 472759002427 ATP binding site [chemical binding]; other site 472759002428 Q-loop/lid; other site 472759002429 ABC transporter signature motif; other site 472759002430 Walker B; other site 472759002431 D-loop; other site 472759002432 H-loop/switch region; other site 472759002433 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 472759002434 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 472759002435 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759002436 S-adenosylmethionine binding site [chemical binding]; other site 472759002437 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 472759002438 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 472759002439 Cysteine-rich domain; Region: CCG; pfam02754 472759002440 Cysteine-rich domain; Region: CCG; pfam02754 472759002441 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 472759002442 diiron binding motif [ion binding]; other site 472759002443 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 472759002444 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 472759002445 TPR repeat; Region: TPR_11; pfam13414 472759002446 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 472759002447 binding surface 472759002448 TPR motif; other site 472759002449 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 472759002450 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 472759002451 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 472759002452 catalytic residues [active] 472759002453 central insert; other site 472759002454 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 472759002455 CcmE; Region: CcmE; pfam03100 472759002456 Heme exporter protein D (CcmD); Region: CcmD; cl11475 472759002457 heme exporter protein CcmC; Region: ccmC; TIGR01191 472759002458 CcmB protein; Region: CcmB; pfam03379 472759002459 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 472759002460 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 472759002461 Walker A/P-loop; other site 472759002462 ATP binding site [chemical binding]; other site 472759002463 Q-loop/lid; other site 472759002464 ABC transporter signature motif; other site 472759002465 Walker B; other site 472759002466 D-loop; other site 472759002467 H-loop/switch region; other site 472759002468 Protein of unknown function (DUF2868); Region: DUF2868; pfam11067 472759002469 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 472759002470 G1 box; other site 472759002471 GTP/Mg2+ binding site [chemical binding]; other site 472759002472 G2 box; other site 472759002473 Switch I region; other site 472759002474 G3 box; other site 472759002475 Switch II region; other site 472759002476 G4 box; other site 472759002477 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 472759002478 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 472759002479 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 472759002480 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 472759002481 active site 472759002482 metal binding site [ion binding]; metal-binding site 472759002483 OsmC-like protein; Region: OsmC; cl00767 472759002484 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 472759002485 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 472759002486 ligand binding site [chemical binding]; other site 472759002487 flexible hinge region; other site 472759002488 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 472759002489 putative switch regulator; other site 472759002490 non-specific DNA interactions [nucleotide binding]; other site 472759002491 DNA binding site [nucleotide binding] 472759002492 sequence specific DNA binding site [nucleotide binding]; other site 472759002493 putative cAMP binding site [chemical binding]; other site 472759002494 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 472759002495 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 472759002496 TrkA-C domain; Region: TrkA_C; pfam02080 472759002497 TrkA-C domain; Region: TrkA_C; pfam02080 472759002498 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 472759002499 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 472759002500 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 472759002501 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 472759002502 Probable Catalytic site; other site 472759002503 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 472759002504 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 472759002505 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 472759002506 trimer interface [polypeptide binding]; other site 472759002507 active site 472759002508 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 472759002509 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 472759002510 active site 472759002511 substrate binding site [chemical binding]; other site 472759002512 cosubstrate binding site; other site 472759002513 catalytic site [active] 472759002514 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 472759002515 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 472759002516 dimerization interface [polypeptide binding]; other site 472759002517 putative ATP binding site [chemical binding]; other site 472759002518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3249 472759002519 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 472759002520 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 472759002521 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 472759002522 DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420 472759002523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 472759002524 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 472759002525 DHH family; Region: DHH; pfam01368 472759002526 DHHA1 domain; Region: DHHA1; pfam02272 472759002527 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 472759002528 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 472759002529 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 472759002530 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 472759002531 Walker A/P-loop; other site 472759002532 ATP binding site [chemical binding]; other site 472759002533 Q-loop/lid; other site 472759002534 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 472759002535 ABC transporter signature motif; other site 472759002536 Walker B; other site 472759002537 D-loop; other site 472759002538 H-loop/switch region; other site 472759002539 CAAX protease self-immunity; Region: Abi; pfam02517 472759002540 ferric uptake regulator; Provisional; Region: fur; PRK09462 472759002541 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 472759002542 metal binding site 2 [ion binding]; metal-binding site 472759002543 putative DNA binding helix; other site 472759002544 metal binding site 1 [ion binding]; metal-binding site 472759002545 dimer interface [polypeptide binding]; other site 472759002546 structural Zn2+ binding site [ion binding]; other site 472759002547 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 472759002548 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 472759002549 RnfH family Ubiquitin; Region: Ub-RnfH; pfam03658 472759002550 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 472759002551 putative coenzyme Q binding site [chemical binding]; other site 472759002552 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 472759002553 Na2 binding site [ion binding]; other site 472759002554 putative substrate binding site 1 [chemical binding]; other site 472759002555 Na binding site 1 [ion binding]; other site 472759002556 putative substrate binding site 2 [chemical binding]; other site 472759002557 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 472759002558 SmpB-tmRNA interface; other site 472759002559 Uncharacterized conserved protein [Function unknown]; Region: COG2361 472759002560 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 472759002561 active site 472759002562 NTP binding site [chemical binding]; other site 472759002563 metal binding triad [ion binding]; metal-binding site 472759002564 antibiotic binding site [chemical binding]; other site 472759002565 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 472759002566 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 472759002567 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 472759002568 ATP binding site [chemical binding]; other site 472759002569 putative Mg++ binding site [ion binding]; other site 472759002570 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 472759002571 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 472759002572 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 472759002573 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 472759002574 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 472759002575 GIY-YIG motif/motif A; other site 472759002576 putative active site [active] 472759002577 putative metal binding site [ion binding]; other site 472759002578 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 472759002579 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 472759002580 HsdM N-terminal domain; Region: HsdM_N; pfam12161 472759002581 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 472759002582 Methyltransferase domain; Region: Methyltransf_26; pfam13659 472759002583 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 472759002584 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 472759002585 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 472759002586 active site 472759002587 HIGH motif; other site 472759002588 nucleotide binding site [chemical binding]; other site 472759002589 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 472759002590 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 472759002591 active site 472759002592 KMSKS motif; other site 472759002593 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 472759002594 tRNA binding surface [nucleotide binding]; other site 472759002595 anticodon binding site; other site 472759002596 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 472759002597 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 472759002598 putative active site [active] 472759002599 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 472759002600 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 472759002601 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 472759002602 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 472759002603 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 472759002604 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 472759002605 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 472759002606 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 472759002607 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 472759002608 Type II transport protein GspH; Region: GspH; pfam12019 472759002609 RRXRR protein; Region: RRXRR; pfam14239 472759002610 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 472759002611 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 472759002612 active site 472759002613 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 472759002614 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 472759002615 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 472759002616 oxidative damage protection protein; Provisional; Region: PRK05408 472759002617 adenine DNA glycosylase; Provisional; Region: PRK10880 472759002618 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 472759002619 minor groove reading motif; other site 472759002620 helix-hairpin-helix signature motif; other site 472759002621 substrate binding pocket [chemical binding]; other site 472759002622 active site 472759002623 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 472759002624 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 472759002625 DNA binding and oxoG recognition site [nucleotide binding] 472759002626 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 472759002627 hydrophobic ligand binding site; other site 472759002628 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 472759002629 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 472759002630 Domain of unknown function DUF21; Region: DUF21; pfam01595 472759002631 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 472759002632 Transporter associated domain; Region: CorC_HlyC; smart01091 472759002633 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 472759002634 signal recognition particle protein; Provisional; Region: PRK10867 472759002635 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 472759002636 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 472759002637 P loop; other site 472759002638 GTP binding site [chemical binding]; other site 472759002639 Signal peptide binding domain; Region: SRP_SPB; pfam02978 472759002640 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 472759002641 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 472759002642 RimM N-terminal domain; Region: RimM; pfam01782 472759002643 PRC-barrel domain; Region: PRC; pfam05239 472759002644 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 472759002645 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 472759002646 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 472759002647 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 472759002648 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 472759002649 DNA binding site [nucleotide binding] 472759002650 active site 472759002651 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 472759002652 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 472759002653 active site 472759002654 DNA binding site [nucleotide binding] 472759002655 Int/Topo IB signature motif; other site 472759002656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 472759002657 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 472759002658 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 472759002659 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 472759002660 dimerization domain [polypeptide binding]; other site 472759002661 dimer interface [polypeptide binding]; other site 472759002662 catalytic residues [active] 472759002663 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 472759002664 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 472759002665 putative active site [active] 472759002666 putative metal binding site [ion binding]; other site 472759002667 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 472759002668 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 472759002669 substrate binding site [chemical binding]; other site 472759002670 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 472759002671 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 472759002672 HIGH motif; other site 472759002673 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 472759002674 active site 472759002675 KMSKS motif; other site 472759002676 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 472759002677 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 472759002678 active site 472759002679 HIGH motif; other site 472759002680 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 472759002681 KMSKS motif; other site 472759002682 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 472759002683 tRNA binding surface [nucleotide binding]; other site 472759002684 anticodon binding site; other site 472759002685 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 472759002686 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 472759002687 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 472759002688 homodimer interface [polypeptide binding]; other site 472759002689 NADP binding site [chemical binding]; other site 472759002690 substrate binding site [chemical binding]; other site 472759002691 Transposase, Mutator family; Region: Transposase_mut; pfam00872 472759002692 MULE transposase domain; Region: MULE; pfam10551 472759002693 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 472759002694 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 472759002695 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 472759002696 HicB family; Region: HicB; pfam05534 472759002697 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 472759002698 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 472759002699 non-specific DNA binding site [nucleotide binding]; other site 472759002700 salt bridge; other site 472759002701 sequence-specific DNA binding site [nucleotide binding]; other site 472759002702 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 472759002703 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 472759002704 non-specific DNA binding site [nucleotide binding]; other site 472759002705 salt bridge; other site 472759002706 sequence-specific DNA binding site [nucleotide binding]; other site 472759002707 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 472759002708 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 472759002709 sequence-specific DNA binding site [nucleotide binding]; other site 472759002710 salt bridge; other site 472759002711 KilA-N domain; Region: KilA-N; pfam04383 472759002712 Transposase, Mutator family; Region: Transposase_mut; pfam00872 472759002713 MULE transposase domain; Region: MULE; pfam10551 472759002714 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 472759002715 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 472759002716 active site 472759002717 DNA binding site [nucleotide binding] 472759002718 Int/Topo IB signature motif; other site 472759002719 Domain of unknown function (DUF4224); Region: DUF4224; pfam13986 472759002720 Uncharacterized conserved protein (DUF2303); Region: DUF2303; cl02338 472759002721 Domain of unknown function (DUF4326); Region: DUF4326; pfam14216 472759002722 Phage associated DNA primase [General function prediction only]; Region: COG3378 472759002723 Protein of unknown function (DUF497); Region: DUF497; cl01108 472759002724 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 472759002725 transcriptional repressor DicA; Reviewed; Region: PRK09706 472759002726 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 472759002727 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 472759002728 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 472759002729 Prophage antirepressor [Transcription]; Region: COG3617 472759002730 BRO family, N-terminal domain; Region: Bro-N; smart01040 472759002731 Prophage antirepressor [Transcription]; Region: COG3617 472759002732 BRO family, N-terminal domain; Region: Bro-N; smart01040 472759002733 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 472759002734 Mor transcription activator family; Region: Mor; cl02360 472759002735 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 472759002736 Coenzyme A binding pocket [chemical binding]; other site 472759002737 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 472759002738 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 472759002739 ORF6N domain; Region: ORF6N; pfam10543 472759002740 Domain of unknown function DUF29; Region: DUF29; pfam01724 472759002741 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 472759002742 catalytic residue [active] 472759002743 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 472759002744 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 472759002745 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 472759002746 oligomer interface [polypeptide binding]; other site 472759002747 active site residues [active] 472759002748 Uncharacterized conserved protein (DUF2190); Region: DUF2190; pfam09956 472759002749 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 472759002750 UV radiation resistance protein and autophagy-related subunit 14; Region: Atg14; pfam10186 472759002751 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 472759002752 non-specific DNA binding site [nucleotide binding]; other site 472759002753 salt bridge; other site 472759002754 sequence-specific DNA binding site [nucleotide binding]; other site 472759002755 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 472759002756 methylamine dehydrogenase (amicyanin) heavy chain; Region: TTQ_MADH_Hv; TIGR02658 472759002757 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14591 472759002758 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 472759002759 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 472759002760 Winged helix-turn helix; Region: HTH_29; pfam13551 472759002761 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 472759002762 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 472759002763 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 472759002764 ligand binding site [chemical binding]; other site 472759002765 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 472759002766 Prominin; Region: Prominin; pfam05478 472759002767 Protein of unknown function (DUF3223); Region: DUF3223; pfam11523 472759002768 Global regulator protein family; Region: CsrA; pfam02599 472759002769 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 472759002770 YcfA-like protein; Region: YcfA; pfam07927 472759002771 Uncharacterized conserved protein [Function unknown]; Region: COG3586 472759002772 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 472759002773 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 472759002774 polymerase nucleotide-binding site; other site 472759002775 DNA-binding residues [nucleotide binding]; DNA binding site 472759002776 nucleotide binding site [chemical binding]; other site 472759002777 primase nucleotide-binding site [nucleotide binding]; other site 472759002778 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 472759002779 D5 N terminal like; Region: D5_N; pfam08706 472759002780 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 472759002781 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 472759002782 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 472759002783 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 472759002784 integrase; Provisional; Region: PRK09692 472759002785 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 472759002786 active site 472759002787 Int/Topo IB signature motif; other site 472759002788 Domain of unknown function DUF29; Region: DUF29; pfam01724 472759002789 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 472759002790 HsdM N-terminal domain; Region: HsdM_N; pfam12161 472759002791 Methyltransferase domain; Region: Methyltransf_26; pfam13659 472759002792 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 472759002793 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 472759002794 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 472759002795 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 472759002796 Protein of unknown function DUF45; Region: DUF45; pfam01863 472759002797 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 472759002798 HicB family; Region: HicB; pfam05534 472759002799 AAA domain; Region: AAA_32; pfam13654 472759002800 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 472759002801 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 472759002802 catalytic core [active] 472759002803 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 472759002804 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 472759002805 N-terminal plug; other site 472759002806 ligand-binding site [chemical binding]; other site 472759002807 ferrochelatase; Reviewed; Region: hemH; PRK00035 472759002808 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 472759002809 C-terminal domain interface [polypeptide binding]; other site 472759002810 active site 472759002811 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 472759002812 active site 472759002813 N-terminal domain interface [polypeptide binding]; other site 472759002814 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 472759002815 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635 472759002816 active site 472759002817 dimer interface [polypeptide binding]; other site 472759002818 catalytic nucleophile [active] 472759002819 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 472759002820 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759002821 S-adenosylmethionine binding site [chemical binding]; other site 472759002822 Predicted GTPase or GTP-binding protein [General function prediction only]; Region: COG1341 472759002823 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 472759002824 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 472759002825 Major Facilitator Superfamily; Region: MFS_1; pfam07690 472759002826 putative substrate translocation pore; other site 472759002827 Predicted deacylase [General function prediction only]; Region: COG3608 472759002828 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 472759002829 putative active site [active] 472759002830 Zn binding site [ion binding]; other site 472759002831 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 472759002832 RimK-like ATP-grasp domain; Region: RimK; pfam08443 472759002833 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 472759002834 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 472759002835 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 472759002836 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 472759002837 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 472759002838 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 472759002839 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 472759002840 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 472759002841 active site 472759002842 ribonuclease Z; Provisional; Region: PRK02126 472759002843 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 472759002844 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 472759002845 poly(A) polymerase; Region: pcnB; TIGR01942 472759002846 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 472759002847 active site 472759002848 NTP binding site [chemical binding]; other site 472759002849 metal binding triad [ion binding]; metal-binding site 472759002850 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 472759002851 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 472759002852 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 472759002853 catalytic center binding site [active] 472759002854 ATP binding site [chemical binding]; other site 472759002855 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 472759002856 oligomerization interface [polypeptide binding]; other site 472759002857 active site 472759002858 metal binding site [ion binding]; metal-binding site 472759002859 pantoate--beta-alanine ligase; Region: panC; TIGR00018 472759002860 Pantoate-beta-alanine ligase; Region: PanC; cd00560 472759002861 active site 472759002862 ATP-binding site [chemical binding]; other site 472759002863 pantoate-binding site; other site 472759002864 HXXH motif; other site 472759002865 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 472759002866 tetramerization interface [polypeptide binding]; other site 472759002867 active site 472759002868 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 472759002869 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 472759002870 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 472759002871 Probable transposase; Region: OrfB_IS605; pfam01385 472759002872 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 472759002873 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 472759002874 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 472759002875 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 472759002876 Multicopper oxidase; Region: Cu-oxidase; pfam00394 472759002877 Cytochrome c; Region: Cytochrom_C; cl11414 472759002878 Cytochrome c; Region: Cytochrom_C; pfam00034 472759002879 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 472759002880 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 472759002881 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 472759002882 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 472759002883 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 472759002884 DNA-binding site [nucleotide binding]; DNA binding site 472759002885 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 472759002886 pyridoxal 5'-phosphate binding site [chemical binding]; other site 472759002887 homodimer interface [polypeptide binding]; other site 472759002888 catalytic residue [active] 472759002889 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 472759002890 Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447 472759002891 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 472759002892 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 472759002893 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 472759002894 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 472759002895 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 472759002896 N-acetyl-D-glucosamine binding site [chemical binding]; other site 472759002897 catalytic residue [active] 472759002898 prolyl-tRNA synthetase; Provisional; Region: PRK09194 472759002899 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 472759002900 dimer interface [polypeptide binding]; other site 472759002901 motif 1; other site 472759002902 active site 472759002903 motif 2; other site 472759002904 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 472759002905 putative deacylase active site [active] 472759002906 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 472759002907 active site 472759002908 motif 3; other site 472759002909 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 472759002910 anticodon binding site; other site 472759002911 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 472759002912 active site 472759002913 multimer interface [polypeptide binding]; other site 472759002914 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 472759002915 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 472759002916 FeS/SAM binding site; other site 472759002917 TPR repeat; Region: TPR_11; pfam13414 472759002918 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 472759002919 binding surface 472759002920 TPR motif; other site 472759002921 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 472759002922 binding surface 472759002923 Tetratricopeptide repeat; Region: TPR_12; pfam13424 472759002924 TPR motif; other site 472759002925 Tetratricopeptide repeat; Region: TPR_12; pfam13424 472759002926 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 472759002927 Helix-turn-helix domain; Region: HTH_25; pfam13413 472759002928 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 472759002929 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 472759002930 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 472759002931 dimer interface [polypeptide binding]; other site 472759002932 motif 1; other site 472759002933 active site 472759002934 motif 2; other site 472759002935 motif 3; other site 472759002936 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 472759002937 anticodon binding site; other site 472759002938 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 472759002939 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 472759002940 active site 472759002941 dimer interface [polypeptide binding]; other site 472759002942 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 472759002943 dimer interface [polypeptide binding]; other site 472759002944 active site 472759002945 glycogen branching enzyme; Provisional; Region: PRK05402 472759002946 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 472759002947 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 472759002948 active site 472759002949 catalytic site [active] 472759002950 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 472759002951 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 472759002952 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 472759002953 ligand binding site; other site 472759002954 oligomer interface; other site 472759002955 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 472759002956 dimer interface [polypeptide binding]; other site 472759002957 N-terminal domain interface [polypeptide binding]; other site 472759002958 sulfate 1 binding site; other site 472759002959 4-alpha-glucanotransferase; Provisional; Region: PRK14508 472759002960 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 472759002961 lipoyl attachment site [posttranslational modification]; other site 472759002962 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 472759002963 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 472759002964 tetramer interface [polypeptide binding]; other site 472759002965 pyridoxal 5'-phosphate binding site [chemical binding]; other site 472759002966 catalytic residue [active] 472759002967 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 472759002968 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 472759002969 putative peptidase; Provisional; Region: PRK11649 472759002970 Peptidase family M23; Region: Peptidase_M23; pfam01551 472759002971 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 472759002972 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 472759002973 active site 472759002974 HIGH motif; other site 472759002975 dimer interface [polypeptide binding]; other site 472759002976 KMSKS motif; other site 472759002977 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 472759002978 RNA binding surface [nucleotide binding]; other site 472759002979 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 472759002980 catalytic core [active] 472759002981 Methyltransferase domain; Region: Methyltransf_31; pfam13847 472759002982 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759002983 S-adenosylmethionine binding site [chemical binding]; other site 472759002984 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 472759002985 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 472759002986 Glycoprotease family; Region: Peptidase_M22; pfam00814 472759002987 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 472759002988 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 472759002989 FeS/SAM binding site; other site 472759002990 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 472759002991 Methyltransferase domain; Region: Methyltransf_31; pfam13847 472759002992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759002993 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 472759002994 MutS domain I; Region: MutS_I; pfam01624 472759002995 MutS domain II; Region: MutS_II; pfam05188 472759002996 MutS domain III; Region: MutS_III; pfam05192 472759002997 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 472759002998 Walker A/P-loop; other site 472759002999 ATP binding site [chemical binding]; other site 472759003000 Q-loop/lid; other site 472759003001 ABC transporter signature motif; other site 472759003002 Walker B; other site 472759003003 D-loop; other site 472759003004 H-loop/switch region; other site 472759003005 Competence-damaged protein; Region: CinA; cl00666 472759003006 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 472759003007 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 472759003008 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 472759003009 recombinase A; Provisional; Region: recA; PRK09354 472759003010 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 472759003011 hexamer interface [polypeptide binding]; other site 472759003012 Walker A motif; other site 472759003013 ATP binding site [chemical binding]; other site 472759003014 Walker B motif; other site 472759003015 recombination regulator RecX; Reviewed; Region: recX; PRK00117 472759003016 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 472759003017 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 472759003018 motif 1; other site 472759003019 active site 472759003020 motif 2; other site 472759003021 motif 3; other site 472759003022 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 472759003023 DHHA1 domain; Region: DHHA1; pfam02272 472759003024 aspartate kinase; Reviewed; Region: PRK06635 472759003025 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 472759003026 putative nucleotide binding site [chemical binding]; other site 472759003027 putative catalytic residues [active] 472759003028 putative Mg ion binding site [ion binding]; other site 472759003029 putative aspartate binding site [chemical binding]; other site 472759003030 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 472759003031 putative allosteric regulatory site; other site 472759003032 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 472759003033 putative allosteric regulatory residue; other site 472759003034 carbon storage regulator; Provisional; Region: PRK01712 472759003035 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 472759003036 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 472759003037 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 472759003038 non-specific DNA binding site [nucleotide binding]; other site 472759003039 salt bridge; other site 472759003040 sequence-specific DNA binding site [nucleotide binding]; other site 472759003041 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 472759003042 Transposase [DNA replication, recombination, and repair]; Region: COG5421 472759003043 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 472759003044 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 472759003045 Helix-turn-helix; Region: HTH_3; pfam01381 472759003046 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 472759003047 Helix-turn-helix domain; Region: HTH_36; pfam13730 472759003048 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 472759003049 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 472759003050 tetramer interface [polypeptide binding]; other site 472759003051 heme binding pocket [chemical binding]; other site 472759003052 NADPH binding site [chemical binding]; other site 472759003053 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 472759003054 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 472759003055 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 472759003056 sequence-specific DNA binding site [nucleotide binding]; other site 472759003057 salt bridge; other site 472759003058 Transposase, Mutator family; Region: Transposase_mut; pfam00872 472759003059 MULE transposase domain; Region: MULE; pfam10551 472759003060 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 472759003061 PAS fold; Region: PAS_3; pfam08447 472759003062 putative active site [active] 472759003063 heme pocket [chemical binding]; other site 472759003064 PAS domain S-box; Region: sensory_box; TIGR00229 472759003065 PAS domain; Region: PAS_8; pfam13188 472759003066 putative active site [active] 472759003067 heme pocket [chemical binding]; other site 472759003068 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 472759003069 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 472759003070 metal binding site [ion binding]; metal-binding site 472759003071 active site 472759003072 I-site; other site 472759003073 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 472759003074 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 472759003075 Response regulator receiver domain; Region: Response_reg; pfam00072 472759003076 active site 472759003077 phosphorylation site [posttranslational modification] 472759003078 intermolecular recognition site; other site 472759003079 dimerization interface [polypeptide binding]; other site 472759003080 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 472759003081 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 472759003082 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 472759003083 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 472759003084 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 472759003085 putative dimer interface [polypeptide binding]; other site 472759003086 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 472759003087 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 472759003088 putative dimer interface [polypeptide binding]; other site 472759003089 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 472759003090 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 472759003091 Walker A/P-loop; other site 472759003092 ATP binding site [chemical binding]; other site 472759003093 Q-loop/lid; other site 472759003094 ABC transporter signature motif; other site 472759003095 Walker B; other site 472759003096 D-loop; other site 472759003097 H-loop/switch region; other site 472759003098 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 472759003099 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 472759003100 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 472759003101 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 472759003102 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 472759003103 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 472759003104 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 472759003105 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 472759003106 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 472759003107 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 472759003108 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 472759003109 ring oligomerisation interface [polypeptide binding]; other site 472759003110 ATP/Mg binding site [chemical binding]; other site 472759003111 stacking interactions; other site 472759003112 hinge regions; other site 472759003113 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 472759003114 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 472759003115 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 472759003116 protein binding site [polypeptide binding]; other site 472759003117 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 472759003118 protein binding site [polypeptide binding]; other site 472759003119 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 472759003120 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 472759003121 non-specific DNA binding site [nucleotide binding]; other site 472759003122 salt bridge; other site 472759003123 sequence-specific DNA binding site [nucleotide binding]; other site 472759003124 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 472759003125 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 472759003126 putative active site [active] 472759003127 putative NTP binding site [chemical binding]; other site 472759003128 putative nucleic acid binding site [nucleotide binding]; other site 472759003129 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 472759003130 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 472759003131 ATP binding site [chemical binding]; other site 472759003132 putative Mg++ binding site [ion binding]; other site 472759003133 Family description; Region: UvrD_C_2; pfam13538 472759003134 intracellular protease, PfpI family; Region: PfpI; TIGR01382 472759003135 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 472759003136 proposed catalytic triad [active] 472759003137 conserved cys residue [active] 472759003138 Domain of unknown function DUF77; Region: DUF77; pfam01910 472759003139 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 472759003140 catalytic core [active] 472759003141 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; pfam10095 472759003142 Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752 472759003143 Protein of unknown function, DUF393; Region: DUF393; pfam04134 472759003144 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 472759003145 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 472759003146 PAP2 superfamily; Region: PAP2; pfam01569 472759003147 active site 472759003148 Transposase IS200 like; Region: Y1_Tnp; pfam01797 472759003149 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 472759003150 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 472759003151 Probable transposase; Region: OrfB_IS605; pfam01385 472759003152 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 472759003153 Uncharacterized conserved protein [Function unknown]; Region: COG0398 472759003154 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 472759003155 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 472759003156 putative catalytic site [active] 472759003157 putative metal binding site [ion binding]; other site 472759003158 putative phosphate binding site [ion binding]; other site 472759003159 RibD C-terminal domain; Region: RibD_C; cl17279 472759003160 Uncharacterized ArCR, COG1888; Region: DUF211; pfam02680 472759003161 VIT family; Region: VIT1; pfam01988 472759003162 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 472759003163 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 472759003164 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 472759003165 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 472759003166 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 472759003167 active site 472759003168 motif I; other site 472759003169 motif II; other site 472759003170 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 472759003171 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 472759003172 Protein of unknown function (DUF3374); Region: DUF3374; cl11904 472759003173 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 472759003174 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 472759003175 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 472759003176 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 472759003177 nudix motif; other site 472759003178 CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673 472759003179 CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562 472759003180 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 472759003181 CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cl12127 472759003182 CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737 472759003183 CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cl09835 472759003184 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 472759003185 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 472759003186 FtsX-like permease family; Region: FtsX; pfam02687 472759003187 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 472759003188 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 472759003189 FtsX-like permease family; Region: FtsX; pfam02687 472759003190 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 472759003191 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 472759003192 Walker A/P-loop; other site 472759003193 ATP binding site [chemical binding]; other site 472759003194 Q-loop/lid; other site 472759003195 ABC transporter signature motif; other site 472759003196 Walker B; other site 472759003197 D-loop; other site 472759003198 H-loop/switch region; other site 472759003199 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 472759003200 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 472759003201 HlyD family secretion protein; Region: HlyD_3; pfam13437 472759003202 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 472759003203 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 472759003204 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 472759003205 Ligand Binding Site [chemical binding]; other site 472759003206 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 472759003207 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 472759003208 tetramer interface [polypeptide binding]; other site 472759003209 active site 472759003210 Mg2+/Mn2+ binding site [ion binding]; other site 472759003211 Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108 472759003212 dimer interface [polypeptide binding]; other site 472759003213 Citrate synthase; Region: Citrate_synt; pfam00285 472759003214 active site 472759003215 citrylCoA binding site [chemical binding]; other site 472759003216 oxalacetate/citrate binding site [chemical binding]; other site 472759003217 coenzyme A binding site [chemical binding]; other site 472759003218 catalytic triad [active] 472759003219 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 472759003220 2-methylcitrate dehydratase; Region: prpD; TIGR02330 472759003221 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 472759003222 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 472759003223 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 472759003224 putative active site [active] 472759003225 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 472759003226 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 472759003227 E3 interaction surface; other site 472759003228 lipoyl attachment site [posttranslational modification]; other site 472759003229 e3 binding domain; Region: E3_binding; pfam02817 472759003230 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 472759003231 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 472759003232 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 472759003233 alpha subunit interface [polypeptide binding]; other site 472759003234 TPP binding site [chemical binding]; other site 472759003235 heterodimer interface [polypeptide binding]; other site 472759003236 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 472759003237 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 472759003238 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 472759003239 TPP-binding site [chemical binding]; other site 472759003240 tetramer interface [polypeptide binding]; other site 472759003241 heterodimer interface [polypeptide binding]; other site 472759003242 phosphorylation loop region [posttranslational modification] 472759003243 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 472759003244 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 472759003245 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 472759003246 NAD binding site [chemical binding]; other site 472759003247 Phe binding site; other site 472759003248 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 472759003249 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 472759003250 kynureninase; Region: kynureninase; TIGR01814 472759003251 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 472759003252 catalytic residue [active] 472759003253 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 472759003254 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 472759003255 dimer interface [polypeptide binding]; other site 472759003256 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 472759003257 active site 472759003258 Fe binding site [ion binding]; other site 472759003259 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 472759003260 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 472759003261 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 472759003262 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 472759003263 maleylacetoacetate isomerase; Region: maiA; TIGR01262 472759003264 C-terminal domain interface [polypeptide binding]; other site 472759003265 GSH binding site (G-site) [chemical binding]; other site 472759003266 putative dimer interface [polypeptide binding]; other site 472759003267 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 472759003268 dimer interface [polypeptide binding]; other site 472759003269 N-terminal domain interface [polypeptide binding]; other site 472759003270 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 472759003271 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 472759003272 CoenzymeA binding site [chemical binding]; other site 472759003273 subunit interaction site [polypeptide binding]; other site 472759003274 PHB binding site; other site 472759003275 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 472759003276 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 472759003277 phosphopeptide binding site; other site 472759003278 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 472759003279 GAF domain; Region: GAF; pfam01590 472759003280 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 472759003281 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 472759003282 acyl-CoA esterase; Provisional; Region: PRK10673 472759003283 PGAP1-like protein; Region: PGAP1; pfam07819 472759003284 Response regulator receiver domain; Region: Response_reg; pfam00072 472759003285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 472759003286 active site 472759003287 phosphorylation site [posttranslational modification] 472759003288 intermolecular recognition site; other site 472759003289 dimerization interface [polypeptide binding]; other site 472759003290 PAS domain S-box; Region: sensory_box; TIGR00229 472759003291 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 472759003292 putative active site [active] 472759003293 heme pocket [chemical binding]; other site 472759003294 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 472759003295 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 472759003296 metal binding site [ion binding]; metal-binding site 472759003297 active site 472759003298 I-site; other site 472759003299 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 472759003300 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 472759003301 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 472759003302 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 472759003303 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 472759003304 inhibitor-cofactor binding pocket; inhibition site 472759003305 pyridoxal 5'-phosphate binding site [chemical binding]; other site 472759003306 catalytic residue [active] 472759003307 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 472759003308 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 472759003309 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 472759003310 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 472759003311 active site 472759003312 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 472759003313 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 472759003314 GcpE protein; Region: GcpE; pfam04551 472759003315 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 472759003316 putative membrane protein; Region: HpnL; TIGR03476 472759003317 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 472759003318 hopanoid biosynthesis associated membrane protein HpnM; Region: HpnM; TIGR03481 472759003319 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 472759003320 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 472759003321 active site 472759003322 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 472759003323 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 472759003324 FeS/SAM binding site; other site 472759003325 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 472759003326 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 472759003327 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 472759003328 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 472759003329 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 472759003330 TPP-binding site; other site 472759003331 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 472759003332 PYR/PP interface [polypeptide binding]; other site 472759003333 dimer interface [polypeptide binding]; other site 472759003334 TPP binding site [chemical binding]; other site 472759003335 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 472759003336 CopC domain; Region: CopC; pfam04234 472759003337 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 472759003338 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 472759003339 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 472759003340 active site 472759003341 catalytic site [active] 472759003342 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 472759003343 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 472759003344 THF binding site; other site 472759003345 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 472759003346 substrate binding site [chemical binding]; other site 472759003347 THF binding site; other site 472759003348 zinc-binding site [ion binding]; other site 472759003349 hopanoid C-3 methylase HpnR; Region: HpnR_B12_rSAM; TIGR04367 472759003350 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 472759003351 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 472759003352 FeS/SAM binding site; other site 472759003353 CHASE4 domain; Region: CHASE4; cl01308 472759003354 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 472759003355 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 472759003356 active site 472759003357 ATP binding site [chemical binding]; other site 472759003358 substrate binding site [chemical binding]; other site 472759003359 activation loop (A-loop); other site 472759003360 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 472759003361 MgtE intracellular N domain; Region: MgtE_N; smart00924 472759003362 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 472759003363 Divalent cation transporter; Region: MgtE; pfam01769 472759003364 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 472759003365 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 472759003366 active site 472759003367 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 472759003368 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 472759003369 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 472759003370 putative dimerization interface [polypeptide binding]; other site 472759003371 SEC-C motif; Region: SEC-C; pfam02810 472759003372 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 472759003373 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 472759003374 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 472759003375 putative NAD(P) binding site [chemical binding]; other site 472759003376 active site 472759003377 DoxX-like family; Region: DoxX_3; pfam13781 472759003378 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 472759003379 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 472759003380 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 472759003381 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 472759003382 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 472759003383 non-specific DNA binding site [nucleotide binding]; other site 472759003384 salt bridge; other site 472759003385 sequence-specific DNA binding site [nucleotide binding]; other site 472759003386 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 472759003387 Protein of unknown function (DUF497); Region: DUF497; pfam04365 472759003388 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 472759003389 Protein of unknown function (DUF497); Region: DUF497; pfam04365 472759003390 Predicted periplasmic protein [Function unknown]; Region: COG3904 472759003391 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 472759003392 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 472759003393 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 472759003394 integron integrase; Region: integrase_gron; TIGR02249 472759003395 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 472759003396 Int/Topo IB signature motif; other site 472759003397 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 472759003398 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 472759003399 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 472759003400 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 472759003401 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 472759003402 putative active site [active] 472759003403 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 472759003404 HD domain; Region: HD_4; pfam13328 472759003405 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 472759003406 synthetase active site [active] 472759003407 NTP binding site [chemical binding]; other site 472759003408 metal binding site [ion binding]; metal-binding site 472759003409 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 472759003410 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 472759003411 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 472759003412 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 472759003413 ATP binding site [chemical binding]; other site 472759003414 putative Mg++ binding site [ion binding]; other site 472759003415 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 472759003416 nucleotide binding region [chemical binding]; other site 472759003417 ATP-binding site [chemical binding]; other site 472759003418 Helicase associated domain (HA2); Region: HA2; pfam04408 472759003419 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 472759003420 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 472759003421 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 472759003422 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 472759003423 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 472759003424 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 472759003425 RNA binding site [nucleotide binding]; other site 472759003426 Domain of unknown function (DUF2024); Region: DUF2024; pfam09630 472759003427 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 472759003428 Flavodoxin; Region: Flavodoxin_1; pfam00258 472759003429 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 472759003430 FAD binding pocket [chemical binding]; other site 472759003431 FAD binding motif [chemical binding]; other site 472759003432 catalytic residues [active] 472759003433 NAD binding pocket [chemical binding]; other site 472759003434 phosphate binding motif [ion binding]; other site 472759003435 beta-alpha-beta structure motif; other site 472759003436 sulfite reductase subunit beta; Provisional; Region: PRK13504 472759003437 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 472759003438 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 472759003439 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 472759003440 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 472759003441 dimer interface [polypeptide binding]; other site 472759003442 decamer (pentamer of dimers) interface [polypeptide binding]; other site 472759003443 catalytic triad [active] 472759003444 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 472759003445 Peptidase family M48; Region: Peptidase_M48; pfam01435 472759003446 aminopeptidase N; Provisional; Region: pepN; PRK14015 472759003447 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 472759003448 active site 472759003449 Zn binding site [ion binding]; other site 472759003450 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 472759003451 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 472759003452 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 472759003453 catalytic residue [active] 472759003454 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 472759003455 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 472759003456 PYR/PP interface [polypeptide binding]; other site 472759003457 dimer interface [polypeptide binding]; other site 472759003458 TPP binding site [chemical binding]; other site 472759003459 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 472759003460 TPP-binding site [chemical binding]; other site 472759003461 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 472759003462 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 472759003463 tetramer interface [polypeptide binding]; other site 472759003464 active site 472759003465 Mg2+/Mn2+ binding site [ion binding]; other site 472759003466 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 472759003467 active site 472759003468 metal-binding site 472759003469 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 472759003470 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 472759003471 active site 472759003472 metal-binding site 472759003473 hopanoid-associated phosphorylase; Region: HpnG; TIGR03468 472759003474 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 472759003475 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 472759003476 Active site cavity [active] 472759003477 catalytic acid [active] 472759003478 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 472759003479 active site lid residues [active] 472759003480 substrate binding pocket [chemical binding]; other site 472759003481 catalytic residues [active] 472759003482 substrate-Mg2+ binding site; other site 472759003483 aspartate-rich region 1; other site 472759003484 aspartate-rich region 2; other site 472759003485 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 472759003486 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 472759003487 active site 472759003488 phosphorylation site [posttranslational modification] 472759003489 intermolecular recognition site; other site 472759003490 dimerization interface [polypeptide binding]; other site 472759003491 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 472759003492 GAF domain; Region: GAF; pfam01590 472759003493 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 472759003494 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 472759003495 PAS domain; Region: PAS_9; pfam13426 472759003496 putative active site [active] 472759003497 heme pocket [chemical binding]; other site 472759003498 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 472759003499 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 472759003500 ATP binding site [chemical binding]; other site 472759003501 Mg2+ binding site [ion binding]; other site 472759003502 G-X-G motif; other site 472759003503 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 472759003504 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 472759003505 Chain length determinant protein; Region: Wzz; pfam02706 472759003506 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 472759003507 Chain length determinant protein; Region: Wzz; cl15801 472759003508 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 472759003509 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 472759003510 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 472759003511 TPR motif; other site 472759003512 binding surface 472759003513 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 472759003514 O-Antigen ligase; Region: Wzy_C; pfam04932 472759003515 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 472759003516 active site 472759003517 dimer interface [polypeptide binding]; other site 472759003518 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 472759003519 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 472759003520 putative ribose interaction site [chemical binding]; other site 472759003521 putative ADP binding site [chemical binding]; other site 472759003522 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 472759003523 active site 472759003524 HIGH motif; other site 472759003525 nucleotide binding site [chemical binding]; other site 472759003526 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 472759003527 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 472759003528 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 472759003529 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 472759003530 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 472759003531 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 472759003532 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 472759003533 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 472759003534 putative active site [active] 472759003535 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 472759003536 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 472759003537 putative ADP-binding pocket [chemical binding]; other site 472759003538 Right handed beta helix region; Region: Beta_helix; pfam13229 472759003539 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 472759003540 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 472759003541 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 472759003542 NADP-binding site; other site 472759003543 homotetramer interface [polypeptide binding]; other site 472759003544 substrate binding site [chemical binding]; other site 472759003545 homodimer interface [polypeptide binding]; other site 472759003546 active site 472759003547 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 472759003548 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 472759003549 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 472759003550 NADP binding site [chemical binding]; other site 472759003551 active site 472759003552 putative substrate binding site [chemical binding]; other site 472759003553 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 472759003554 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 472759003555 SLBB domain; Region: SLBB; pfam10531 472759003556 Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022 472759003557 Bacterial sugar transferase; Region: Bac_transf; pfam02397 472759003558 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 472759003559 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 472759003560 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 472759003561 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 472759003562 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 472759003563 active site 472759003564 FMN binding site [chemical binding]; other site 472759003565 substrate binding site [chemical binding]; other site 472759003566 putative catalytic residue [active] 472759003567 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 472759003568 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 472759003569 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 472759003570 active site 472759003571 nucleophile elbow; other site 472759003572 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 472759003573 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 472759003574 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 472759003575 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 472759003576 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 472759003577 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 472759003578 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 472759003579 putative active site; other site 472759003580 catalytic residue [active] 472759003581 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 472759003582 Acylphosphatase; Region: Acylphosphatase; pfam00708 472759003583 HypF finger; Region: zf-HYPF; pfam07503 472759003584 HypF finger; Region: zf-HYPF; pfam07503 472759003585 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 472759003586 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 472759003587 Malic enzyme, N-terminal domain; Region: malic; pfam00390 472759003588 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 472759003589 putative NAD(P) binding site [chemical binding]; other site 472759003590 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 472759003591 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 472759003592 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 472759003593 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 472759003594 active site 472759003595 nucleophile elbow; other site 472759003596 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 472759003597 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 472759003598 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 472759003599 HupF/HypC family; Region: HupF_HypC; pfam01455 472759003600 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 472759003601 dimer interface [polypeptide binding]; other site 472759003602 active site 472759003603 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 472759003604 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 472759003605 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 472759003606 dimerization interface [polypeptide binding]; other site 472759003607 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 472759003608 ATP binding site [chemical binding]; other site 472759003609 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 472759003610 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 472759003611 DNA binding residues [nucleotide binding] 472759003612 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 472759003613 catalytic residues [active] 472759003614 catalytic nucleophile [active] 472759003615 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 472759003616 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 472759003617 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 472759003618 catalytic core [active] 472759003619 Y-family of DNA polymerases; Region: PolY; cl12025 472759003620 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 472759003621 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 472759003622 putative active site [active] 472759003623 putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Validated; Region: PRK06567 472759003624 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 472759003625 FAD binding pocket [chemical binding]; other site 472759003626 FAD binding motif [chemical binding]; other site 472759003627 phosphate binding motif [ion binding]; other site 472759003628 beta-alpha-beta structure motif; other site 472759003629 NAD binding pocket [chemical binding]; other site 472759003630 Iron coordination center [ion binding]; other site 472759003631 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 472759003632 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 472759003633 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 472759003634 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 472759003635 ATP-binding cassette domain of MutS homologs; Region: ABC_MutS_homologs; cd03243 472759003636 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 472759003637 Walker A/P-loop; other site 472759003638 ATP binding site [chemical binding]; other site 472759003639 Q-loop/lid; other site 472759003640 ABC transporter signature motif; other site 472759003641 Walker B; other site 472759003642 D-loop; other site 472759003643 H-loop/switch region; other site 472759003644 Ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding domain of the alpha/beta class and a discrete (usually N-terminal) domain which varies in orientation with respect to the NAD(P) binding domain. The N-terminal region...; Region: FNR_like_1; cd06196 472759003645 FAD binding pocket [chemical binding]; other site 472759003646 FAD binding motif [chemical binding]; other site 472759003647 phosphate binding motif [ion binding]; other site 472759003648 beta-alpha-beta structure motif; other site 472759003649 NAD binding pocket [chemical binding]; other site 472759003650 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 472759003651 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 472759003652 metal binding site [ion binding]; metal-binding site 472759003653 dimer interface [polypeptide binding]; other site 472759003654 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 472759003655 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 472759003656 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 472759003657 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 472759003658 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 472759003659 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 472759003660 XdhC Rossmann domain; Region: XdhC_C; pfam13478 472759003661 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 472759003662 classical (c) SDRs; Region: SDR_c; cd05233 472759003663 NAD(P) binding site [chemical binding]; other site 472759003664 active site 472759003665 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 472759003666 Found in ATP-dependent protease La (LON); Region: LON; smart00464 472759003667 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759003668 Walker A motif; other site 472759003669 ATP binding site [chemical binding]; other site 472759003670 Walker B motif; other site 472759003671 arginine finger; other site 472759003672 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 472759003673 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 472759003674 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 472759003675 putative dimer interface [polypeptide binding]; other site 472759003676 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 472759003677 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 472759003678 putative active site [active] 472759003679 putative dimer interface [polypeptide binding]; other site 472759003680 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 472759003681 GTP cyclohydrolase I; Provisional; Region: PLN03044 472759003682 homodecamer interface [polypeptide binding]; other site 472759003683 active site 472759003684 putative catalytic site residues [active] 472759003685 zinc binding site [ion binding]; other site 472759003686 GTP-CH-I/GFRP interaction surface; other site 472759003687 PhoU domain; Region: PhoU; pfam01895 472759003688 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 472759003689 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 472759003690 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 472759003691 RRXRR protein; Region: RRXRR; pfam14239 472759003692 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 472759003693 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 472759003694 active site 472759003695 S-adenosylmethionine synthetase; Validated; Region: PRK05250 472759003696 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 472759003697 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 472759003698 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 472759003699 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 472759003700 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 472759003701 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 472759003702 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 472759003703 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 472759003704 Soluble P-type ATPase [General function prediction only]; Region: COG4087 472759003705 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 472759003706 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 472759003707 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759003708 S-adenosylmethionine binding site [chemical binding]; other site 472759003709 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 472759003710 dimer interface [polypeptide binding]; other site 472759003711 substrate binding site [chemical binding]; other site 472759003712 ATP binding site [chemical binding]; other site 472759003713 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 472759003714 MoaE interaction surface [polypeptide binding]; other site 472759003715 MoeB interaction surface [polypeptide binding]; other site 472759003716 thiocarboxylated glycine; other site 472759003717 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK08762 472759003718 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 472759003719 active site residue [active] 472759003720 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 472759003721 ATP binding site [chemical binding]; other site 472759003722 substrate interface [chemical binding]; other site 472759003723 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 472759003724 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 472759003725 PYR/PP interface [polypeptide binding]; other site 472759003726 dimer interface [polypeptide binding]; other site 472759003727 TPP binding site [chemical binding]; other site 472759003728 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 472759003729 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 472759003730 TPP-binding site [chemical binding]; other site 472759003731 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 472759003732 active site 472759003733 oxalacetate binding site [chemical binding]; other site 472759003734 citrylCoA binding site [chemical binding]; other site 472759003735 coenzyme A binding site [chemical binding]; other site 472759003736 catalytic triad [active] 472759003737 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 472759003738 citrylCoA binding site [chemical binding]; other site 472759003739 oxalacetate binding site [chemical binding]; other site 472759003740 coenzyme A binding site [chemical binding]; other site 472759003741 catalytic triad [active] 472759003742 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 472759003743 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 472759003744 N-terminal plug; other site 472759003745 ligand-binding site [chemical binding]; other site 472759003746 short chain dehydrogenase; Provisional; Region: PRK06500 472759003747 classical (c) SDRs; Region: SDR_c; cd05233 472759003748 NAD(P) binding site [chemical binding]; other site 472759003749 active site 472759003750 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 472759003751 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 472759003752 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 472759003753 dimer interface [polypeptide binding]; other site 472759003754 phosphorylation site [posttranslational modification] 472759003755 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 472759003756 ATP binding site [chemical binding]; other site 472759003757 Mg2+ binding site [ion binding]; other site 472759003758 G-X-G motif; other site 472759003759 Response regulator receiver domain; Region: Response_reg; pfam00072 472759003760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 472759003761 active site 472759003762 phosphorylation site [posttranslational modification] 472759003763 intermolecular recognition site; other site 472759003764 dimerization interface [polypeptide binding]; other site 472759003765 Response regulator receiver domain; Region: Response_reg; pfam00072 472759003766 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 472759003767 active site 472759003768 phosphorylation site [posttranslational modification] 472759003769 intermolecular recognition site; other site 472759003770 dimerization interface [polypeptide binding]; other site 472759003771 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 472759003772 putative binding surface; other site 472759003773 active site 472759003774 Response regulator receiver domain; Region: Response_reg; pfam00072 472759003775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 472759003776 active site 472759003777 phosphorylation site [posttranslational modification] 472759003778 intermolecular recognition site; other site 472759003779 dimerization interface [polypeptide binding]; other site 472759003780 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 472759003781 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 472759003782 metal binding site [ion binding]; metal-binding site 472759003783 active site 472759003784 I-site; other site 472759003785 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 472759003786 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 472759003787 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 472759003788 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 472759003789 FtsX-like permease family; Region: FtsX; pfam02687 472759003790 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 472759003791 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 472759003792 Walker A/P-loop; other site 472759003793 ATP binding site [chemical binding]; other site 472759003794 Q-loop/lid; other site 472759003795 ABC transporter signature motif; other site 472759003796 Walker B; other site 472759003797 D-loop; other site 472759003798 H-loop/switch region; other site 472759003799 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 472759003800 nucleoside/Zn binding site; other site 472759003801 dimer interface [polypeptide binding]; other site 472759003802 catalytic motif [active] 472759003803 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 472759003804 FAD binding domain; Region: FAD_binding_4; pfam01565 472759003805 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 472759003806 CAAX protease self-immunity; Region: Abi; pfam02517 472759003807 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 472759003808 TPR motif; other site 472759003809 Tetratricopeptide repeat; Region: TPR_16; pfam13432 472759003810 binding surface 472759003811 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 472759003812 TPR repeat; Region: TPR_11; pfam13414 472759003813 TPR motif; other site 472759003814 TPR repeat; Region: TPR_11; pfam13414 472759003815 binding surface 472759003816 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 472759003817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 472759003818 active site 472759003819 phosphorylation site [posttranslational modification] 472759003820 intermolecular recognition site; other site 472759003821 dimerization interface [polypeptide binding]; other site 472759003822 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 472759003823 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 472759003824 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 472759003825 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759003826 Walker A motif; other site 472759003827 ATP binding site [chemical binding]; other site 472759003828 Walker B motif; other site 472759003829 arginine finger; other site 472759003830 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 472759003831 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 472759003832 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 472759003833 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 472759003834 BON domain; Region: BON; pfam04972 472759003835 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 472759003836 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 472759003837 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 472759003838 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 472759003839 TadE-like protein; Region: TadE; pfam07811 472759003840 TadE-like protein; Region: TadE; pfam07811 472759003841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 472759003842 active site 472759003843 dimerization interface [polypeptide binding]; other site 472759003844 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 472759003845 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 472759003846 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 472759003847 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 472759003848 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 472759003849 ATP binding site [chemical binding]; other site 472759003850 Walker A motif; other site 472759003851 hexamer interface [polypeptide binding]; other site 472759003852 Walker B motif; other site 472759003853 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 472759003854 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 472759003855 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 472759003856 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 472759003857 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 472759003858 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 472759003859 inhibitor-cofactor binding pocket; inhibition site 472759003860 pyridoxal 5'-phosphate binding site [chemical binding]; other site 472759003861 catalytic residue [active] 472759003862 aldehyde dehydrogenase family 7 member; Region: PLN02315 472759003863 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 472759003864 tetrameric interface [polypeptide binding]; other site 472759003865 NAD binding site [chemical binding]; other site 472759003866 catalytic residues [active] 472759003867 Indoleamine 2,3-dioxygenase; Region: IDO; pfam01231 472759003868 Water Stress and Hypersensitive response; Region: WHy; smart00769 472759003869 Dodecin; Region: Dodecin; pfam07311 472759003870 Ferritin-like domain; Region: Ferritin; pfam00210 472759003871 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 472759003872 dinuclear metal binding motif [ion binding]; other site 472759003873 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 472759003874 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 472759003875 FeS/SAM binding site; other site 472759003876 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 472759003877 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 472759003878 Proline dehydrogenase; Region: Pro_dh; pfam01619 472759003879 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 472759003880 Glutamate binding site [chemical binding]; other site 472759003881 NAD binding site [chemical binding]; other site 472759003882 catalytic residues [active] 472759003883 Response regulator receiver domain; Region: Response_reg; pfam00072 472759003884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 472759003885 active site 472759003886 phosphorylation site [posttranslational modification] 472759003887 intermolecular recognition site; other site 472759003888 dimerization interface [polypeptide binding]; other site 472759003889 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 472759003890 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 472759003891 putative active site [active] 472759003892 heme pocket [chemical binding]; other site 472759003893 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 472759003894 dimer interface [polypeptide binding]; other site 472759003895 phosphorylation site [posttranslational modification] 472759003896 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 472759003897 ATP binding site [chemical binding]; other site 472759003898 Mg2+ binding site [ion binding]; other site 472759003899 G-X-G motif; other site 472759003900 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 472759003901 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 472759003902 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 472759003903 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 472759003904 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 472759003905 DNA binding residues [nucleotide binding] 472759003906 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 472759003907 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 472759003908 active site 472759003909 phosphorylation site [posttranslational modification] 472759003910 intermolecular recognition site; other site 472759003911 dimerization interface [polypeptide binding]; other site 472759003912 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 472759003913 DNA binding residues [nucleotide binding] 472759003914 dimerization interface [polypeptide binding]; other site 472759003915 Response regulator receiver domain; Region: Response_reg; pfam00072 472759003916 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 472759003917 active site 472759003918 phosphorylation site [posttranslational modification] 472759003919 intermolecular recognition site; other site 472759003920 dimerization interface [polypeptide binding]; other site 472759003921 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 472759003922 PAS domain; Region: PAS_9; pfam13426 472759003923 putative active site [active] 472759003924 heme pocket [chemical binding]; other site 472759003925 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 472759003926 dimer interface [polypeptide binding]; other site 472759003927 phosphorylation site [posttranslational modification] 472759003928 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 472759003929 ATP binding site [chemical binding]; other site 472759003930 Mg2+ binding site [ion binding]; other site 472759003931 G-X-G motif; other site 472759003932 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 472759003933 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 472759003934 D-xylulose kinase; Region: XylB; TIGR01312 472759003935 nucleotide binding site [chemical binding]; other site 472759003936 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 472759003937 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 472759003938 AAA domain; Region: AAA_23; pfam13476 472759003939 Walker A/P-loop; other site 472759003940 ATP binding site [chemical binding]; other site 472759003941 Q-loop/lid; other site 472759003942 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 472759003943 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 472759003944 ABC transporter signature motif; other site 472759003945 Walker B; other site 472759003946 D-loop; other site 472759003947 H-loop/switch region; other site 472759003948 ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354 472759003949 FtsZ protein binding site [polypeptide binding]; other site 472759003950 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 472759003951 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 472759003952 nucleotide binding pocket [chemical binding]; other site 472759003953 K-X-D-G motif; other site 472759003954 catalytic site [active] 472759003955 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 472759003956 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 472759003957 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 472759003958 Dimer interface [polypeptide binding]; other site 472759003959 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 472759003960 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 472759003961 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 472759003962 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 472759003963 Outer membrane lipoprotein Slp family; Region: Slp; pfam03843 472759003964 Protein of unknown function (DUF1134); Region: DUF1134; pfam06577 472759003965 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 472759003966 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 472759003967 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 472759003968 ABC transporter; Region: ABC_tran_2; pfam12848 472759003969 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 472759003970 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 472759003971 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_1; cd08581 472759003972 putative active site [active] 472759003973 catalytic site [active] 472759003974 putative metal binding site [ion binding]; other site 472759003975 PAS fold; Region: PAS_4; pfam08448 472759003976 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 472759003977 putative active site [active] 472759003978 heme pocket [chemical binding]; other site 472759003979 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 472759003980 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 472759003981 putative active site [active] 472759003982 heme pocket [chemical binding]; other site 472759003983 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 472759003984 dimer interface [polypeptide binding]; other site 472759003985 phosphorylation site [posttranslational modification] 472759003986 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 472759003987 ATP binding site [chemical binding]; other site 472759003988 Mg2+ binding site [ion binding]; other site 472759003989 G-X-G motif; other site 472759003990 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 472759003991 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 472759003992 Holliday junction resolvasome, helicase subunit [DNA replication, recombination, and repair]; Region: RuvB; COG2255 472759003993 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759003994 Walker A motif; other site 472759003995 ATP binding site [chemical binding]; other site 472759003996 Walker B motif; other site 472759003997 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 472759003998 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 472759003999 non-specific DNA binding site [nucleotide binding]; other site 472759004000 salt bridge; other site 472759004001 sequence-specific DNA binding site [nucleotide binding]; other site 472759004002 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 472759004003 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 472759004004 hypothetical protein; Provisional; Region: PRK09256 472759004005 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 472759004006 NRDE protein; Region: NRDE; cl01315 472759004007 Domain of unknown function DUF87; Region: DUF87; pfam01935 472759004008 AAA-like domain; Region: AAA_10; pfam12846 472759004009 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 472759004010 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 472759004011 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 472759004012 putative substrate binding site [chemical binding]; other site 472759004013 nucleotide binding site [chemical binding]; other site 472759004014 nucleotide binding site [chemical binding]; other site 472759004015 homodimer interface [polypeptide binding]; other site 472759004016 Predicted GTPase [General function prediction only]; Region: COG2403 472759004017 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 472759004018 aconitate hydratase; Validated; Region: PRK07229 472759004019 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 472759004020 substrate binding site [chemical binding]; other site 472759004021 ligand binding site [chemical binding]; other site 472759004022 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 472759004023 substrate binding site [chemical binding]; other site 472759004024 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 472759004025 active site flap/lid [active] 472759004026 nucleophilic elbow; other site 472759004027 catalytic triad [active] 472759004028 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 472759004029 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 472759004030 Transposase, Mutator family; Region: Transposase_mut; pfam00872 472759004031 MULE transposase domain; Region: MULE; pfam10551 472759004032 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 472759004033 AAA ATPase domain; Region: AAA_16; pfam13191 472759004034 Uncharacterized conserved protein [Function unknown]; Region: COG1262 472759004035 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 472759004036 TIR domain; Region: TIR_2; pfam13676 472759004037 WbqC-like protein family; Region: WbqC; pfam08889 472759004038 EcsC protein family; Region: EcsC; pfam12787 472759004039 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 472759004040 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 472759004041 Helicase; Region: Helicase_RecD; pfam05127 472759004042 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 472759004043 Coenzyme A binding pocket [chemical binding]; other site 472759004044 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 472759004045 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 472759004046 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 472759004047 ligand binding site; other site 472759004048 oligomer interface; other site 472759004049 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 472759004050 dimer interface [polypeptide binding]; other site 472759004051 N-terminal domain interface [polypeptide binding]; other site 472759004052 sulfate 1 binding site; other site 472759004053 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 472759004054 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 472759004055 putative active site [active] 472759004056 putative metal binding site [ion binding]; other site 472759004057 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 472759004058 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 472759004059 Sel1-like repeats; Region: SEL1; smart00671 472759004060 Sel1-like repeats; Region: SEL1; smart00671 472759004061 Sel1-like repeats; Region: SEL1; smart00671 472759004062 Sel1-like repeats; Region: SEL1; smart00671 472759004063 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 472759004064 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 472759004065 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 472759004066 homoserine O-succinyltransferase; Provisional; Region: PRK05368 472759004067 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 472759004068 proposed active site lysine [active] 472759004069 conserved cys residue [active] 472759004070 OsmC-like protein; Region: OsmC; cl00767 472759004071 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 472759004072 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 472759004073 active site 472759004074 metal binding site [ion binding]; metal-binding site 472759004075 NAD-dependent deacetylase; Provisional; Region: PRK05333 472759004076 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 472759004077 NAD+ binding site [chemical binding]; other site 472759004078 substrate binding site [chemical binding]; other site 472759004079 Zn binding site [ion binding]; other site 472759004080 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 472759004081 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 472759004082 DXD motif; other site 472759004083 VacJ like lipoprotein; Region: VacJ; cl01073 472759004084 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 472759004085 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 472759004086 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 472759004087 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 472759004088 Multicopper oxidase; Region: Cu-oxidase; pfam00394 472759004089 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 472759004090 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 472759004091 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759004092 Walker A motif; other site 472759004093 ATP binding site [chemical binding]; other site 472759004094 Walker B motif; other site 472759004095 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 472759004096 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 472759004097 FMN binding site [chemical binding]; other site 472759004098 active site 472759004099 substrate binding site [chemical binding]; other site 472759004100 catalytic residue [active] 472759004101 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 472759004102 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 472759004103 N-acetyl-D-glucosamine binding site [chemical binding]; other site 472759004104 catalytic residue [active] 472759004105 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 472759004106 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 472759004107 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 472759004108 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 472759004109 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 472759004110 active site 472759004111 Zn binding site [ion binding]; other site 472759004112 YcjX-like family, DUF463; Region: DUF463; pfam04317 472759004113 hypothetical protein; Provisional; Region: PRK05415 472759004114 Domain of unknown function (DUF697); Region: DUF697; cl12064 472759004115 Uncharacterized conserved protein [Function unknown]; Region: COG1615 472759004116 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 472759004117 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 472759004118 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 472759004119 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 472759004120 Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941 472759004121 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 472759004122 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 472759004123 FAD binding pocket [chemical binding]; other site 472759004124 FAD binding motif [chemical binding]; other site 472759004125 phosphate binding motif [ion binding]; other site 472759004126 beta-alpha-beta structure motif; other site 472759004127 NAD binding pocket [chemical binding]; other site 472759004128 Iron coordination center [ion binding]; other site 472759004129 sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910 472759004130 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 472759004131 DDE superfamily endonuclease; Region: DDE_3; pfam13358 472759004132 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 472759004133 Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839 472759004134 Transposase, Mutator family; Region: Transposase_mut; pfam00872 472759004135 MULE transposase domain; Region: MULE; pfam10551 472759004136 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 472759004137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 472759004138 active site 472759004139 phosphorylation site [posttranslational modification] 472759004140 intermolecular recognition site; other site 472759004141 dimerization interface [polypeptide binding]; other site 472759004142 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 472759004143 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 472759004144 active site 472759004145 phosphorylation site [posttranslational modification] 472759004146 intermolecular recognition site; other site 472759004147 dimerization interface [polypeptide binding]; other site 472759004148 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 472759004149 DNA binding residues [nucleotide binding] 472759004150 dimerization interface [polypeptide binding]; other site 472759004151 Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648 472759004152 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 472759004153 Cytochrome c; Region: Cytochrom_C; pfam00034 472759004154 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 472759004155 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 472759004156 D-pathway; other site 472759004157 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 472759004158 Binuclear center (active site) [active] 472759004159 K-pathway; other site 472759004160 Putative proton exit pathway; other site 472759004161 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759004162 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 472759004163 Walker A motif; other site 472759004164 ATP binding site [chemical binding]; other site 472759004165 Walker B motif; other site 472759004166 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 472759004167 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 472759004168 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 472759004169 metal ion-dependent adhesion site (MIDAS); other site 472759004170 phosphoenolpyruvate synthase; Validated; Region: PRK06464 472759004171 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 472759004172 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 472759004173 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 472759004174 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 472759004175 Uncharacterized conserved protein [Function unknown]; Region: COG4850 472759004176 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 472759004177 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 472759004178 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 472759004179 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 472759004180 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 472759004181 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 472759004182 amino acid transporter; Region: 2A0306; TIGR00909 472759004183 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04135 472759004184 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 472759004185 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 472759004186 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 472759004187 putative substrate binding site [chemical binding]; other site 472759004188 putative ATP binding site [chemical binding]; other site 472759004189 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 472759004190 CoA binding domain; Region: CoA_binding_2; pfam13380 472759004191 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 472759004192 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 472759004193 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 472759004194 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 472759004195 EF-hand domain pair; Region: EF_hand_5; pfam13499 472759004196 Ca2+ binding site [ion binding]; other site 472759004197 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 472759004198 EF-hand domain pair; Region: EF_hand_5; pfam13499 472759004199 Ca2+ binding site [ion binding]; other site 472759004200 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 472759004201 putative active site [active] 472759004202 transaldolase; Provisional; Region: PRK03903 472759004203 catalytic residue [active] 472759004204 transketolase; Reviewed; Region: PRK05899 472759004205 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 472759004206 TPP-binding site [chemical binding]; other site 472759004207 dimer interface [polypeptide binding]; other site 472759004208 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 472759004209 PYR/PP interface [polypeptide binding]; other site 472759004210 dimer interface [polypeptide binding]; other site 472759004211 TPP binding site [chemical binding]; other site 472759004212 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 472759004213 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 472759004214 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 472759004215 active site 472759004216 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 472759004217 catalytic triad [active] 472759004218 metal binding site [ion binding]; metal-binding site 472759004219 conserved cis-peptide bond; other site 472759004220 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 472759004221 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 472759004222 FtsH Extracellular; Region: FtsH_ext; pfam06480 472759004223 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 472759004224 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 472759004225 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759004226 Walker A motif; other site 472759004227 ATP binding site [chemical binding]; other site 472759004228 Walker B motif; other site 472759004229 arginine finger; other site 472759004230 Peptidase family M41; Region: Peptidase_M41; pfam01434 472759004231 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759004232 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 472759004233 Walker A motif; other site 472759004234 ATP binding site [chemical binding]; other site 472759004235 Walker B motif; other site 472759004236 arginine finger; other site 472759004237 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 472759004238 CsbD-like; Region: CsbD; cl17424 472759004239 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 472759004240 pseudo EF-hand loop; other site 472759004241 peptide binding pocket; other site 472759004242 Ca2+ binding site [ion binding]; other site 472759004243 PRC-barrel domain; Region: PRC; pfam05239 472759004244 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 472759004245 Predicted membrane protein [Function unknown]; Region: COG4325 472759004246 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 472759004247 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 472759004248 Probable transposase; Region: OrfB_IS605; pfam01385 472759004249 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 472759004250 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 472759004251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 472759004252 active site 472759004253 phosphorylation site [posttranslational modification] 472759004254 intermolecular recognition site; other site 472759004255 dimerization interface [polypeptide binding]; other site 472759004256 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 472759004257 DNA binding residues [nucleotide binding] 472759004258 dimerization interface [polypeptide binding]; other site 472759004259 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 472759004260 catalytic motif [active] 472759004261 Catalytic residue [active] 472759004262 PRC-barrel domain; Region: PRC; pfam05239 472759004263 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 472759004264 EF-hand domain pair; Region: EF_hand_5; pfam13499 472759004265 Ca2+ binding site [ion binding]; other site 472759004266 BON domain; Region: BON; pfam04972 472759004267 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 472759004268 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 472759004269 Walker A/P-loop; other site 472759004270 ATP binding site [chemical binding]; other site 472759004271 Q-loop/lid; other site 472759004272 ABC transporter signature motif; other site 472759004273 Walker B; other site 472759004274 D-loop; other site 472759004275 H-loop/switch region; other site 472759004276 TOBE domain; Region: TOBE_2; pfam08402 472759004277 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 472759004278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 472759004279 dimer interface [polypeptide binding]; other site 472759004280 conserved gate region; other site 472759004281 ABC-ATPase subunit interface; other site 472759004282 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 472759004283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 472759004284 dimer interface [polypeptide binding]; other site 472759004285 conserved gate region; other site 472759004286 putative PBP binding loops; other site 472759004287 ABC-ATPase subunit interface; other site 472759004288 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 472759004289 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 472759004290 ATP cone domain; Region: ATP-cone; pfam03477 472759004291 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 472759004292 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 472759004293 protein-splicing catalytic site; other site 472759004294 thioester formation/cholesterol transfer; other site 472759004295 LAGLIDADG DNA endonuclease family; Region: LAGLIDADG_2; pfam03161 472759004296 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 472759004297 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 472759004298 LysR family transcriptional regulator; Provisional; Region: PRK14997 472759004299 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 472759004300 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 472759004301 putative effector binding pocket; other site 472759004302 dimerization interface [polypeptide binding]; other site 472759004303 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 472759004304 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 472759004305 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 472759004306 4Fe-4S binding domain; Region: Fer4; cl02805 472759004307 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 472759004308 [4Fe-4S] binding site [ion binding]; other site 472759004309 molybdopterin cofactor binding site; other site 472759004310 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 472759004311 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 472759004312 molybdopterin cofactor binding site; other site 472759004313 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 472759004314 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 472759004315 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 472759004316 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 472759004317 Protein of unknown function (DUF3306); Region: DUF3306; pfam11748 472759004318 Protein of unknown function (DUF3305); Region: DUF3305; pfam11749 472759004319 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 472759004320 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 472759004321 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 472759004322 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 472759004323 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 472759004324 hypothetical protein; Provisional; Region: PRK10279 472759004325 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 472759004326 nucleophile elbow; other site 472759004327 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 472759004328 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 472759004329 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 472759004330 putative active site [active] 472759004331 putative active site [active] 472759004332 catalytic site [active] 472759004333 catalytic site [active] 472759004334 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 472759004335 putative active site [active] 472759004336 catalytic site [active] 472759004337 Uncharacterized conserved protein [Function unknown]; Region: COG0398 472759004338 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 472759004339 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 472759004340 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759004341 Walker A motif; other site 472759004342 ATP binding site [chemical binding]; other site 472759004343 Walker B motif; other site 472759004344 arginine finger; other site 472759004345 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 472759004346 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 472759004347 catalytic residues [active] 472759004348 AAA domain; Region: AAA_32; pfam13654 472759004349 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 472759004350 Protein of unknown function (DUF2959); Region: DUF2959; pfam11172 472759004351 Adenylation domain of RNA circularization proteins; Region: Adenylation_RNA_ligase; cd07894 472759004352 active site 472759004353 dimer interface [polypeptide binding]; other site 472759004354 hypothetical protein; Provisional; Region: PRK04358 472759004355 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 472759004356 30S subunit binding site; other site 472759004357 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 472759004358 DNA-binding site [nucleotide binding]; DNA binding site 472759004359 RNA-binding motif; other site 472759004360 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 472759004361 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 472759004362 oligomer interface [polypeptide binding]; other site 472759004363 metal binding site [ion binding]; metal-binding site 472759004364 metal binding site [ion binding]; metal-binding site 472759004365 Cl binding site [ion binding]; other site 472759004366 aspartate ring; other site 472759004367 basic sphincter; other site 472759004368 putative hydrophobic gate; other site 472759004369 periplasmic entrance; other site 472759004370 Protein of unknown function, DUF599; Region: DUF599; cl01575 472759004371 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 472759004372 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 472759004373 HlyD family secretion protein; Region: HlyD_3; pfam13437 472759004374 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 472759004375 Protein of unknown function (DUF3374); Region: DUF3374; cl11904 472759004376 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 472759004377 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 472759004378 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 472759004379 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 472759004380 Cytochrome c; Region: Cytochrom_C; pfam00034 472759004381 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 472759004382 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 472759004383 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 472759004384 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 472759004385 FAD binding pocket [chemical binding]; other site 472759004386 FAD binding motif [chemical binding]; other site 472759004387 phosphate binding motif [ion binding]; other site 472759004388 beta-alpha-beta structure motif; other site 472759004389 NAD binding pocket [chemical binding]; other site 472759004390 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 472759004391 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 472759004392 DNA binding residues [nucleotide binding] 472759004393 dimer interface [polypeptide binding]; other site 472759004394 metal binding site [ion binding]; metal-binding site 472759004395 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 472759004396 metal-binding site [ion binding] 472759004397 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 472759004398 NHL repeat; Region: NHL; pfam01436 472759004399 Uncharacterized conserved protein [Function unknown]; Region: COG3391 472759004400 NHL repeat; Region: NHL; pfam01436 472759004401 NHL repeat; Region: NHL; pfam01436 472759004402 NHL repeat; Region: NHL; pfam01436 472759004403 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 472759004404 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 472759004405 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 472759004406 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 472759004407 YtkA-like; Region: YtkA; pfam13115 472759004408 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 472759004409 HlyD family secretion protein; Region: HlyD_3; pfam13437 472759004410 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 472759004411 putative mercuric reductase; Provisional; Region: PRK14727 472759004412 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 472759004413 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 472759004414 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 472759004415 Membrane transport protein MerF; Region: Transport_MerF; pfam11431 472759004416 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 472759004417 metal-binding site [ion binding] 472759004418 MerT mercuric transport protein; Region: MerT; cl03578 472759004419 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 472759004420 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 472759004421 DNA binding residues [nucleotide binding] 472759004422 dimer interface [polypeptide binding]; other site 472759004423 putative metal binding site [ion binding]; other site 472759004424 Uncharacterized conserved protein [Function unknown]; Region: COG1742 472759004425 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 472759004426 HlyD family secretion protein; Region: HlyD_3; pfam13437 472759004427 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 472759004428 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 472759004429 Outer membrane efflux protein; Region: OEP; pfam02321 472759004430 Outer membrane efflux protein; Region: OEP; pfam02321 472759004431 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 472759004432 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 472759004433 HlyD family secretion protein; Region: HlyD_3; pfam13437 472759004434 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 472759004435 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 472759004436 hypothetical protein; Provisional; Region: PRK09272 472759004437 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 472759004438 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 472759004439 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 472759004440 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 472759004441 motif II; other site 472759004442 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 472759004443 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 472759004444 Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose; Region: GT1_Trehalose_phosphorylase; cd03792 472759004445 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 472759004446 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 472759004447 Short C-terminal domain; Region: SHOCT; pfam09851 472759004448 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 472759004449 Radical SAM superfamily; Region: Radical_SAM; pfam04055 472759004450 FeS/SAM binding site; other site 472759004451 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 472759004452 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 472759004453 putative active site [active] 472759004454 heme pocket [chemical binding]; other site 472759004455 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 472759004456 phosphorylation site [posttranslational modification] 472759004457 dimer interface [polypeptide binding]; other site 472759004458 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 472759004459 ATP binding site [chemical binding]; other site 472759004460 G-X-G motif; other site 472759004461 RRXRR protein; Region: RRXRR; pfam14239 472759004462 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 472759004463 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 472759004464 active site 472759004465 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 472759004466 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 472759004467 Soluble P-type ATPase [General function prediction only]; Region: COG4087 472759004468 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 472759004469 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 472759004470 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 472759004471 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 472759004472 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 472759004473 Uncharacterized conserved protein [Function unknown]; Region: COG2128 472759004474 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 472759004475 Domain of unknown function DUF20; Region: UPF0118; pfam01594 472759004476 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 472759004477 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 472759004478 CHASE2 domain; Region: CHASE2; pfam05226 472759004479 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 472759004480 cyclase homology domain; Region: CHD; cd07302 472759004481 nucleotidyl binding site; other site 472759004482 metal binding site [ion binding]; metal-binding site 472759004483 dimer interface [polypeptide binding]; other site 472759004484 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 472759004485 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 472759004486 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 472759004487 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 472759004488 ligand binding site [chemical binding]; other site 472759004489 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 472759004490 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 472759004491 Sel1-like repeats; Region: SEL1; smart00671 472759004492 Sel1-like repeats; Region: SEL1; smart00671 472759004493 Caspase domain; Region: Peptidase_C14; pfam00656 472759004494 Phosphate-starvation-inducible E; Region: PsiE; pfam06146 472759004495 Hemin uptake protein hemP; Region: hemP; pfam10636 472759004496 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 472759004497 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 472759004498 N-terminal plug; other site 472759004499 ligand-binding site [chemical binding]; other site 472759004500 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 472759004501 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 472759004502 Lysozyme family protein [General function prediction only]; Region: COG5526 472759004503 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 472759004504 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 472759004505 Walker A/P-loop; other site 472759004506 ATP binding site [chemical binding]; other site 472759004507 Q-loop/lid; other site 472759004508 ABC transporter signature motif; other site 472759004509 Walker B; other site 472759004510 D-loop; other site 472759004511 H-loop/switch region; other site 472759004512 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 472759004513 Protein of unknown function (DUF433); Region: DUF433; pfam04255 472759004514 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 472759004515 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 472759004516 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 472759004517 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 472759004518 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 472759004519 Penicillinase repressor; Region: Pencillinase_R; cl17580 472759004520 Peptidase family M48; Region: Peptidase_M48; cl12018 472759004521 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 472759004522 Outer membrane efflux protein; Region: OEP; pfam02321 472759004523 Outer membrane efflux protein; Region: OEP; pfam02321 472759004524 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 472759004525 HlyD family secretion protein; Region: HlyD_3; pfam13437 472759004526 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 472759004527 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 472759004528 hydrophobic ligand binding site; other site 472759004529 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 472759004530 O-methyltransferase; Region: Methyltransf_2; pfam00891 472759004531 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 472759004532 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 472759004533 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 472759004534 HlyD family secretion protein; Region: HlyD_3; pfam13437 472759004535 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 472759004536 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 472759004537 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 472759004538 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 472759004539 putative active site [active] 472759004540 catalytic site [active] 472759004541 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 472759004542 putative active site [active] 472759004543 catalytic site [active] 472759004544 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 472759004545 FAD binding domain; Region: FAD_binding_4; pfam01565 472759004546 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 472759004547 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 472759004548 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 472759004549 Thioredoxin; Region: Thioredoxin_4; pfam13462 472759004550 Na+/H+ antiporter 1; Region: Na_H_antiport_1; pfam06965 472759004551 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 472759004552 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 472759004553 NAD(P) binding site [chemical binding]; other site 472759004554 catalytic residues [active] 472759004555 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 472759004556 putative active site [active] 472759004557 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 472759004558 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 472759004559 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 472759004560 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 472759004561 putative active site [active] 472759004562 metal binding site [ion binding]; metal-binding site 472759004563 Predicted membrane protein [Function unknown]; Region: COG2259 472759004564 Transcriptional regulator [Transcription]; Region: LysR; COG0583 472759004565 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 472759004566 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 472759004567 dimerization interface [polypeptide binding]; other site 472759004568 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 472759004569 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 472759004570 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 472759004571 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 472759004572 Methyltransferase domain; Region: Methyltransf_31; pfam13847 472759004573 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759004574 S-adenosylmethionine binding site [chemical binding]; other site 472759004575 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 472759004576 Bacterial PH domain; Region: DUF304; pfam03703 472759004577 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 472759004578 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 472759004579 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 472759004580 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 472759004581 Predicted transcriptional regulator containing an HTH domain fused to a Zn-ribbon [Transcription]; Region: COG3357 472759004582 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 472759004583 FeS/SAM binding site; other site 472759004584 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 472759004585 high affinity sulphate transporter 1; Region: sulP; TIGR00815 472759004586 Sulfate transporter family; Region: Sulfate_transp; pfam00916 472759004587 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 472759004588 Cytochrome c; Region: Cytochrom_C; pfam00034 472759004589 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 472759004590 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 472759004591 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 472759004592 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 472759004593 Walker A/P-loop; other site 472759004594 ATP binding site [chemical binding]; other site 472759004595 Q-loop/lid; other site 472759004596 ABC transporter signature motif; other site 472759004597 Walker B; other site 472759004598 D-loop; other site 472759004599 H-loop/switch region; other site 472759004600 MbtH-like protein; Region: MbtH; cl01279 472759004601 Condensation domain; Region: Condensation; pfam00668 472759004602 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 472759004603 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 472759004604 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 472759004605 acyl-activating enzyme (AAE) consensus motif; other site 472759004606 AMP binding site [chemical binding]; other site 472759004607 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 472759004608 Condensation domain; Region: Condensation; pfam00668 472759004609 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 472759004610 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 472759004611 Condensation domain; Region: Condensation; pfam00668 472759004612 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 472759004613 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 472759004614 acyl-activating enzyme (AAE) consensus motif; other site 472759004615 AMP binding site [chemical binding]; other site 472759004616 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 472759004617 Condensation domain; Region: Condensation; pfam00668 472759004618 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 472759004619 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 472759004620 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 472759004621 acyl-activating enzyme (AAE) consensus motif; other site 472759004622 AMP binding site [chemical binding]; other site 472759004623 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 472759004624 Condensation domain; Region: Condensation; pfam00668 472759004625 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 472759004626 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 472759004627 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 472759004628 acyl-activating enzyme (AAE) consensus motif; other site 472759004629 AMP binding site [chemical binding]; other site 472759004630 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 472759004631 Condensation domain; Region: Condensation; pfam00668 472759004632 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 472759004633 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 472759004634 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 472759004635 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 472759004636 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 472759004637 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 472759004638 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 472759004639 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 472759004640 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 472759004641 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 472759004642 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 472759004643 Secretin and TonB N terminus short domain; Region: STN; smart00965 472759004644 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 472759004645 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 472759004646 N-terminal plug; other site 472759004647 ligand-binding site [chemical binding]; other site 472759004648 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 472759004649 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 472759004650 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 472759004651 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 472759004652 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 472759004653 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 472759004654 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 472759004655 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 472759004656 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 472759004657 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 472759004658 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 472759004659 Walker A/P-loop; other site 472759004660 ATP binding site [chemical binding]; other site 472759004661 Q-loop/lid; other site 472759004662 ABC transporter signature motif; other site 472759004663 Walker B; other site 472759004664 D-loop; other site 472759004665 H-loop/switch region; other site 472759004666 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 472759004667 ligand-binding site [chemical binding]; other site 472759004668 RRXRR protein; Region: RRXRR; pfam14239 472759004669 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 472759004670 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 472759004671 active site 472759004672 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 472759004673 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 472759004674 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 472759004675 N-terminal plug; other site 472759004676 ligand-binding site [chemical binding]; other site 472759004677 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 472759004678 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 472759004679 N-terminal plug; other site 472759004680 ligand-binding site [chemical binding]; other site 472759004681 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 472759004682 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 472759004683 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 472759004684 motif II; other site 472759004685 Cytochrome c [Energy production and conversion]; Region: COG3258 472759004686 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 472759004687 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 472759004688 active site 472759004689 metal binding site [ion binding]; metal-binding site 472759004690 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 472759004691 Domain of unknown function DUF29; Region: DUF29; pfam01724 472759004692 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: HyfB; COG0651 472759004693 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 472759004694 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 472759004695 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 472759004696 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 472759004697 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 472759004698 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 472759004699 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 472759004700 Domain of unknown function (DUF4040); Region: DUF4040; pfam13244 472759004701 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 472759004702 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 472759004703 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 472759004704 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 472759004705 Ligand Binding Site [chemical binding]; other site 472759004706 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 472759004707 Ligand Binding Site [chemical binding]; other site 472759004708 RRXRR protein; Region: RRXRR; pfam14239 472759004709 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 472759004710 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 472759004711 active site 472759004712 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 472759004713 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 472759004714 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 472759004715 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 472759004716 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 472759004717 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 472759004718 motif II; other site 472759004719 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 472759004720 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 472759004721 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 472759004722 Domain of unknown function DUF20; Region: UPF0118; pfam01594 472759004723 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 472759004724 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 472759004725 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 472759004726 TrkA-N domain; Region: TrkA_N; pfam02254 472759004727 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 472759004728 Ligand Binding Site [chemical binding]; other site 472759004729 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 472759004730 Ligand Binding Site [chemical binding]; other site 472759004731 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 472759004732 Ligand Binding Site [chemical binding]; other site 472759004733 NnrS protein; Region: NnrS; pfam05940 472759004734 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 472759004735 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 472759004736 heme binding site [chemical binding]; other site 472759004737 ferroxidase pore; other site 472759004738 ferroxidase diiron center [ion binding]; other site 472759004739 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 472759004740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 472759004741 putative substrate translocation pore; other site 472759004742 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 472759004743 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 472759004744 DDE superfamily endonuclease; Region: DDE_3; pfam13358 472759004745 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 472759004746 MbtH-like protein; Region: MbtH; cl01279 472759004747 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 472759004748 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 472759004749 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 472759004750 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 472759004751 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 472759004752 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 472759004753 motif II; other site 472759004754 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 472759004755 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 472759004756 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 472759004757 Domain of unknown function DUF20; Region: UPF0118; pfam01594 472759004758 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 472759004759 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 472759004760 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 472759004761 TrkA-N domain; Region: TrkA_N; pfam02254 472759004762 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 472759004763 Ligand Binding Site [chemical binding]; other site 472759004764 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 472759004765 Ligand Binding Site [chemical binding]; other site 472759004766 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 472759004767 Ligand Binding Site [chemical binding]; other site 472759004768 NnrS protein; Region: NnrS; pfam05940 472759004769 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 472759004770 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 472759004771 heme binding site [chemical binding]; other site 472759004772 ferroxidase pore; other site 472759004773 ferroxidase diiron center [ion binding]; other site 472759004774 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 472759004775 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 472759004776 putative substrate translocation pore; other site 472759004777 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 472759004778 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 472759004779 DDE superfamily endonuclease; Region: DDE_3; pfam13358 472759004780 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 472759004781 MbtH-like protein; Region: MbtH; cl01279 472759004782 Post-segregation antitoxin CcdA; Region: CcdA; cl02188 472759004783 PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855 472759004784 putative active site [active] 472759004785 replication factor A; Reviewed; Region: PRK12366 472759004786 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 472759004787 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 472759004788 HlyD family secretion protein; Region: HlyD_3; pfam13437 472759004789 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 472759004790 putative active site [active] 472759004791 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 472759004792 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 472759004793 Predicted periplasmic lipoprotein (DUF2279); Region: DUF2279; pfam10043 472759004794 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 472759004795 MutS domain I; Region: MutS_I; pfam01624 472759004796 MutS domain II; Region: MutS_II; pfam05188 472759004797 MutS domain III; Region: MutS_III; pfam05192 472759004798 MutS domain V; Region: MutS_V; pfam00488 472759004799 Walker A/P-loop; other site 472759004800 ATP binding site [chemical binding]; other site 472759004801 Q-loop/lid; other site 472759004802 ABC transporter signature motif; other site 472759004803 Walker B; other site 472759004804 D-loop; other site 472759004805 H-loop/switch region; other site 472759004806 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 472759004807 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 472759004808 ATP binding site [chemical binding]; other site 472759004809 Mg2+ binding site [ion binding]; other site 472759004810 G-X-G motif; other site 472759004811 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 472759004812 ATP binding site [chemical binding]; other site 472759004813 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 472759004814 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 472759004815 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 472759004816 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 472759004817 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 472759004818 active site 472759004819 metal binding site [ion binding]; metal-binding site 472759004820 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 472759004821 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 472759004822 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 472759004823 Peptidase M16C associated; Region: M16C_assoc; pfam08367 472759004824 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 472759004825 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 472759004826 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 472759004827 motif II; other site 472759004828 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 472759004829 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 472759004830 dimerization interface [polypeptide binding]; other site 472759004831 domain crossover interface; other site 472759004832 redox-dependent activation switch; other site 472759004833 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 472759004834 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 472759004835 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 472759004836 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 472759004837 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 472759004838 DNA binding residues [nucleotide binding] 472759004839 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 472759004840 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 472759004841 hypothetical protein; Reviewed; Region: PRK09588 472759004842 FOG: CBS domain [General function prediction only]; Region: COG0517 472759004843 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 472759004844 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 472759004845 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 472759004846 putative FMN binding site [chemical binding]; other site 472759004847 NADPH bind site [chemical binding]; other site 472759004848 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 472759004849 CheB methylesterase; Region: CheB_methylest; pfam01339 472759004850 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 472759004851 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 472759004852 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 472759004853 TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926 472759004854 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 472759004855 Uncharacterized protein family (UPF0240); Region: UPF0240; pfam06784 472759004856 PAS domain; Region: PAS_10; pfam13596 472759004857 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 472759004858 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 472759004859 dimer interface [polypeptide binding]; other site 472759004860 phosphorylation site [posttranslational modification] 472759004861 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 472759004862 ATP binding site [chemical binding]; other site 472759004863 Mg2+ binding site [ion binding]; other site 472759004864 G-X-G motif; other site 472759004865 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 472759004866 Response regulator receiver domain; Region: Response_reg; pfam00072 472759004867 active site 472759004868 phosphorylation site [posttranslational modification] 472759004869 intermolecular recognition site; other site 472759004870 dimerization interface [polypeptide binding]; other site 472759004871 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 472759004872 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 472759004873 active site 472759004874 phosphorylation site [posttranslational modification] 472759004875 intermolecular recognition site; other site 472759004876 dimerization interface [polypeptide binding]; other site 472759004877 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 472759004878 DNA binding residues [nucleotide binding] 472759004879 dimerization interface [polypeptide binding]; other site 472759004880 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 472759004881 anti sigma factor interaction site; other site 472759004882 regulatory phosphorylation site [posttranslational modification]; other site 472759004883 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 472759004884 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 472759004885 homotetramer interface [polypeptide binding]; other site 472759004886 ligand binding site [chemical binding]; other site 472759004887 catalytic site [active] 472759004888 NAD binding site [chemical binding]; other site 472759004889 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 472759004890 Cna protein B-type domain; Region: Cna_B_2; pfam13715 472759004891 NHL repeat; Region: NHL; pfam01436 472759004892 NHL repeat; Region: NHL; pfam01436 472759004893 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 472759004894 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 472759004895 Transposase IS200 like; Region: Y1_Tnp; pfam01797 472759004896 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 472759004897 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 472759004898 Transposase, Mutator family; Region: Transposase_mut; pfam00872 472759004899 MULE transposase domain; Region: MULE; pfam10551 472759004900 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 472759004901 core domain interface [polypeptide binding]; other site 472759004902 delta subunit interface [polypeptide binding]; other site 472759004903 epsilon subunit interface [polypeptide binding]; other site 472759004904 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 472759004905 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 472759004906 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 472759004907 Walker A motif; other site 472759004908 ATP binding site [chemical binding]; other site 472759004909 Walker B motif; other site 472759004910 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 472759004911 F0F1 ATP synthase subunit B; Provisional; Region: PRK14474 472759004912 alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321 472759004913 F0F1 ATP synthase subunit C; Provisional; Region: PRK13468 472759004914 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 472759004915 ATP synthase A chain; Region: ATP-synt_A; cl00413 472759004916 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 472759004917 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 472759004918 protein binding site [polypeptide binding]; other site 472759004919 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 472759004920 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 472759004921 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 472759004922 Walker A/P-loop; other site 472759004923 ATP binding site [chemical binding]; other site 472759004924 Q-loop/lid; other site 472759004925 ABC transporter signature motif; other site 472759004926 Walker B; other site 472759004927 D-loop; other site 472759004928 H-loop/switch region; other site 472759004929 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 472759004930 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 472759004931 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 472759004932 putative active site [active] 472759004933 catalytic site [active] 472759004934 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 472759004935 putative active site [active] 472759004936 catalytic site [active] 472759004937 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 472759004938 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 472759004939 NAD(P) binding site [chemical binding]; other site 472759004940 catalytic residues [active] 472759004941 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 472759004942 YcfA-like protein; Region: YcfA; cl00752 472759004943 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 472759004944 HicB family; Region: HicB; pfam05534 472759004945 EF-hand domain pair; Region: EF_hand_5; pfam13499 472759004946 EF hand; Region: efhand; pfam00036 472759004947 Ca2+ binding site [ion binding]; other site 472759004948 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 472759004949 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 472759004950 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 472759004951 active site 472759004952 DNA binding site [nucleotide binding] 472759004953 Int/Topo IB signature motif; other site 472759004954 AAA domain; Region: AAA_25; pfam13481 472759004955 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 472759004956 Walker A motif; other site 472759004957 ATP binding site [chemical binding]; other site 472759004958 Walker B motif; other site 472759004959 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 472759004960 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 472759004961 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 472759004962 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 472759004963 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 472759004964 serine O-acetyltransferase; Region: cysE; TIGR01172 472759004965 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 472759004966 trimer interface [polypeptide binding]; other site 472759004967 active site 472759004968 substrate binding site [chemical binding]; other site 472759004969 CoA binding site [chemical binding]; other site 472759004970 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 472759004971 Rrf2 family protein; Region: rrf2_super; TIGR00738 472759004972 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 472759004973 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 472759004974 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 472759004975 catalytic residue [active] 472759004976 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 472759004977 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 472759004978 YccA-like proteins; Region: YccA_like; cd10433 472759004979 Uncharacterized conserved protein [Function unknown]; Region: COG0397 472759004980 hypothetical protein; Validated; Region: PRK00029 472759004981 DNA polymerase IV; Validated; Region: PRK01810 472759004982 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 472759004983 DDE superfamily endonuclease; Region: DDE_3; pfam13358 472759004984 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 472759004985 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 472759004986 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 472759004987 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 472759004988 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 472759004989 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 472759004990 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 472759004991 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 472759004992 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 472759004993 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 472759004994 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09689 472759004995 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 472759004996 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 472759004997 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 472759004998 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 472759004999 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 472759005000 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 472759005001 F0F1 ATP synthase subunit epsilon; Validated; Region: PRK06228 472759005002 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 472759005003 gamma subunit interface [polypeptide binding]; other site 472759005004 epsilon subunit interface [polypeptide binding]; other site 472759005005 LBP interface [polypeptide binding]; other site 472759005006 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 472759005007 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 472759005008 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 472759005009 alpha subunit interaction interface [polypeptide binding]; other site 472759005010 Walker A motif; other site 472759005011 ATP binding site [chemical binding]; other site 472759005012 Walker B motif; other site 472759005013 inhibitor binding site; inhibition site 472759005014 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 472759005015 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 472759005016 nickel binding site [ion binding]; other site 472759005017 Na+/H+ antiporter 1; Region: Na_H_antiport_1; pfam06965 472759005018 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 472759005019 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 472759005020 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 472759005021 Peptidase family M50; Region: Peptidase_M50; pfam02163 472759005022 active site 472759005023 putative substrate binding region [chemical binding]; other site 472759005024 FOG: CBS domain [General function prediction only]; Region: COG0517 472759005025 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 472759005026 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 472759005027 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 472759005028 DNA binding site [nucleotide binding] 472759005029 catalytic residue [active] 472759005030 H2TH interface [polypeptide binding]; other site 472759005031 putative catalytic residues [active] 472759005032 hypothetical protein; Provisional; Region: PRK08609 472759005033 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 472759005034 active site 472759005035 primer binding site [nucleotide binding]; other site 472759005036 NTP binding site [chemical binding]; other site 472759005037 metal binding triad [ion binding]; metal-binding site 472759005038 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 472759005039 active site 472759005040 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 472759005041 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 472759005042 substrate binding site [chemical binding]; other site 472759005043 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 472759005044 tartrate dehydrogenase; Region: TTC; TIGR02089 472759005045 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 472759005046 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 472759005047 FimV N-terminal domain; Region: FimV_core; TIGR03505 472759005048 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 472759005049 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 472759005050 active site 472759005051 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 472759005052 Probable transposase; Region: OrfB_IS605; pfam01385 472759005053 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 472759005054 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 472759005055 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 472759005056 dimerization interface 3.5A [polypeptide binding]; other site 472759005057 active site 472759005058 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 472759005059 active site 472759005060 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 472759005061 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 472759005062 pyridoxal 5'-phosphate binding site [chemical binding]; other site 472759005063 catalytic residue [active] 472759005064 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 472759005065 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 472759005066 substrate binding site [chemical binding]; other site 472759005067 active site 472759005068 catalytic residues [active] 472759005069 heterodimer interface [polypeptide binding]; other site 472759005070 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 472759005071 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 472759005072 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 472759005073 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 472759005074 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 472759005075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759005076 S-adenosylmethionine binding site [chemical binding]; other site 472759005077 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 472759005078 MarR family; Region: MarR; pfam01047 472759005079 MarR family; Region: MarR_2; cl17246 472759005080 Ectoine synthase; Region: Ectoine_synth; pfam06339 472759005081 aspartate kinase; Validated; Region: PRK09181 472759005082 AAK_AK-Ectoine: Amino Acid Kinase Superfamily (AAK), AK-Ectoine; this CD includes the N-terminal catalytic domain of the aspartokinase of the ectoine (1,4,5,6-tetrahydro-2-methyl pyrimidine-4-carboxylate) biosynthetic pathway found in Methylomicrobium...; Region: AAK_AK-Ectoine; cd04248 472759005083 putative catalytic residues [active] 472759005084 putative nucleotide binding site [chemical binding]; other site 472759005085 putative aspartate binding site [chemical binding]; other site 472759005086 ACT domains located C-terminal to the catalytic domain of the aspartokinase of the ectoine (1,4,5,6-tetrahydro-2-methyl pyrimidine-4-carboxylate) biosynthetic pathway; Region: ACT_AK-Ectoine_1; cd04910 472759005087 allosteric regulatory residue; other site 472759005088 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 472759005089 PAS fold; Region: PAS_3; pfam08447 472759005090 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 472759005091 putative active site [active] 472759005092 heme pocket [chemical binding]; other site 472759005093 PAS fold; Region: PAS_4; pfam08448 472759005094 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 472759005095 putative active site [active] 472759005096 heme pocket [chemical binding]; other site 472759005097 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 472759005098 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 472759005099 putative active site [active] 472759005100 heme pocket [chemical binding]; other site 472759005101 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 472759005102 dimer interface [polypeptide binding]; other site 472759005103 phosphorylation site [posttranslational modification] 472759005104 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 472759005105 ATP binding site [chemical binding]; other site 472759005106 Mg2+ binding site [ion binding]; other site 472759005107 G-X-G motif; other site 472759005108 Response regulator receiver domain; Region: Response_reg; pfam00072 472759005109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 472759005110 active site 472759005111 phosphorylation site [posttranslational modification] 472759005112 intermolecular recognition site; other site 472759005113 dimerization interface [polypeptide binding]; other site 472759005114 exonuclease subunit SbcD; Provisional; Region: PRK10966 472759005115 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 472759005116 active site 472759005117 metal binding site [ion binding]; metal-binding site 472759005118 DNA binding site [nucleotide binding] 472759005119 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 472759005120 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 472759005121 AAA domain; Region: AAA_23; pfam13476 472759005122 Walker A/P-loop; other site 472759005123 ATP binding site [chemical binding]; other site 472759005124 Q-loop/lid; other site 472759005125 exonuclease subunit SbcC; Provisional; Region: PRK10246 472759005126 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 472759005127 ABC transporter signature motif; other site 472759005128 Walker B; other site 472759005129 D-loop; other site 472759005130 H-loop/switch region; other site 472759005131 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 472759005132 HsdM N-terminal domain; Region: HsdM_N; pfam12161 472759005133 Methyltransferase domain; Region: Methyltransf_26; pfam13659 472759005134 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 472759005135 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 472759005136 Fic family protein [Function unknown]; Region: COG3177 472759005137 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 472759005138 Fic/DOC family; Region: Fic; pfam02661 472759005139 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 472759005140 putative DNA binding site [nucleotide binding]; other site 472759005141 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 472759005142 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 472759005143 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 472759005144 putative active site [active] 472759005145 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 472759005146 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 472759005147 ATP binding site [chemical binding]; other site 472759005148 putative Mg++ binding site [ion binding]; other site 472759005149 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 472759005150 Transposase; Region: DEDD_Tnp_IS110; pfam01548 472759005151 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 472759005152 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 472759005153 Putative addiction module component; Region: Unstab_antitox; cl09921 472759005154 Transposase IS200 like; Region: Y1_Tnp; pfam01797 472759005155 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 472759005156 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 472759005157 Probable transposase; Region: OrfB_IS605; pfam01385 472759005158 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 472759005159 Homeodomain-like domain; Region: HTH_23; pfam13384 472759005160 Winged helix-turn helix; Region: HTH_29; pfam13551 472759005161 Homeodomain-like domain; Region: HTH_32; pfam13565 472759005162 DDE superfamily endonuclease; Region: DDE_3; pfam13358 472759005163 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 472759005164 Rdx family; Region: Rdx; cl01407 472759005165 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 472759005166 Protein of unknown function (DUF819); Region: DUF819; cl02317 472759005167 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 472759005168 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 472759005169 PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; pfam10142 472759005170 Protein of unknown function, DUF399; Region: DUF399; pfam04187 472759005171 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 472759005172 protein binding site [polypeptide binding]; other site 472759005173 Peptidase family M48; Region: Peptidase_M48; pfam01435 472759005174 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 472759005175 TPR motif; other site 472759005176 binding surface 472759005177 Tetratricopeptide repeat; Region: TPR_9; pfam13371 472759005178 hypothetical protein; Provisional; Region: PRK05170 472759005179 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 472759005180 CoA binding domain; Region: CoA_binding_2; pfam13380 472759005181 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 472759005182 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 472759005183 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 472759005184 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 472759005185 Coenzyme A binding pocket [chemical binding]; other site 472759005186 Bacterial DNA-binding protein; Region: Bac_DNA_binding; pfam00216 472759005187 IHF dimer interface [polypeptide binding]; other site 472759005188 IHF - DNA interface [nucleotide binding]; other site 472759005189 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 472759005190 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 472759005191 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 472759005192 Walker A motif; other site 472759005193 ATP binding site [chemical binding]; other site 472759005194 Walker B motif; other site 472759005195 Predicted permeases [General function prediction only]; Region: COG0679 472759005196 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 472759005197 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 472759005198 putative MPT binding site; other site 472759005199 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 472759005200 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 472759005201 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 472759005202 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 472759005203 Sodium Bile acid symporter family; Region: SBF; pfam01758 472759005204 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 472759005205 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 472759005206 putative active site [active] 472759005207 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 472759005208 SNF2 Helicase protein; Region: DUF3670; pfam12419 472759005209 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 472759005210 ATP binding site [chemical binding]; other site 472759005211 putative Mg++ binding site [ion binding]; other site 472759005212 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 472759005213 nucleotide binding region [chemical binding]; other site 472759005214 ATP-binding site [chemical binding]; other site 472759005215 Uncharacterized conserved protein [Function unknown]; Region: COG4279 472759005216 SWIM zinc finger; Region: SWIM; pfam04434 472759005217 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 472759005218 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 472759005219 NADPH bind site [chemical binding]; other site 472759005220 putative FMN binding site [chemical binding]; other site 472759005221 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 472759005222 putative FMN binding site [chemical binding]; other site 472759005223 Protein of unknown function (DUF989); Region: DUF989; pfam06181 472759005224 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 472759005225 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 472759005226 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 472759005227 PAS domain; Region: PAS_9; pfam13426 472759005228 putative active site [active] 472759005229 heme pocket [chemical binding]; other site 472759005230 PAS domain; Region: PAS_9; pfam13426 472759005231 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 472759005232 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 472759005233 putative active site [active] 472759005234 heme pocket [chemical binding]; other site 472759005235 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 472759005236 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 472759005237 putative active site [active] 472759005238 heme pocket [chemical binding]; other site 472759005239 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 472759005240 dimer interface [polypeptide binding]; other site 472759005241 phosphorylation site [posttranslational modification] 472759005242 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 472759005243 ATP binding site [chemical binding]; other site 472759005244 Mg2+ binding site [ion binding]; other site 472759005245 G-X-G motif; other site 472759005246 Response regulator receiver domain; Region: Response_reg; pfam00072 472759005247 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 472759005248 active site 472759005249 phosphorylation site [posttranslational modification] 472759005250 intermolecular recognition site; other site 472759005251 dimerization interface [polypeptide binding]; other site 472759005252 Ycf46; Provisional; Region: ycf46; CHL00195 472759005253 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759005254 Walker A motif; other site 472759005255 ATP binding site [chemical binding]; other site 472759005256 Walker B motif; other site 472759005257 arginine finger; other site 472759005258 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 472759005259 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 472759005260 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 472759005261 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 472759005262 catalytic residues [active] 472759005263 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 472759005264 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 472759005265 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 472759005266 putative hydrophobic ligand binding site [chemical binding]; other site 472759005267 Domain of unknown function (DUF336); Region: DUF336; cl01249 472759005268 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 472759005269 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 472759005270 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 472759005271 HSP70 interaction site [polypeptide binding]; other site 472759005272 von Willebrand factor type A domain; Region: VWA_2; pfam13519 472759005273 metal ion-dependent adhesion site (MIDAS); other site 472759005274 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 472759005275 S-adenosylmethionine binding site [chemical binding]; other site 472759005276 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 472759005277 YcfA-like protein; Region: YcfA; pfam07927 472759005278 Transposase IS200 like; Region: Y1_Tnp; cl00848 472759005279 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 472759005280 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 472759005281 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 472759005282 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 472759005283 putative NAD(P) binding site [chemical binding]; other site 472759005284 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 472759005285 RibD C-terminal domain; Region: RibD_C; cl17279 472759005286 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 472759005287 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 472759005288 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 472759005289 Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400 472759005290 7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402 472759005291 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 472759005292 Sugar-transfer associated ATP-grasp; Region: ATPgrasp_ST; pfam14397 472759005293 amino acid transporter; Region: 2A0306; TIGR00909 472759005294 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 472759005295 active site 472759005296 Fe-S cluster binding site [ion binding]; other site 472759005297 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 472759005298 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 472759005299 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 472759005300 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 472759005301 M42 glutamyl aminopeptidase; Region: Peptidase_M42; pfam05343 472759005302 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 472759005303 Ferritin-like domain; Region: Ferritin; pfam00210 472759005304 ferroxidase diiron center [ion binding]; other site 472759005305 Transcriptional regulators [Transcription]; Region: MarR; COG1846 472759005306 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 472759005307 Protoglobin; Region: Protoglobin; pfam11563 472759005308 nitrosocyanin; Region: nitroso_cyanin; TIGR03096 472759005309 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 472759005310 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 472759005311 HIGH motif; other site 472759005312 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 472759005313 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 472759005314 active site 472759005315 KMSKS motif; other site 472759005316 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 472759005317 tRNA binding surface [nucleotide binding]; other site 472759005318 anticodon binding site; other site 472759005319 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 472759005320 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 472759005321 putative acyl-acceptor binding pocket; other site 472759005322 Uncharacterized conserved protein [Function unknown]; Region: COG2135 472759005323 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 472759005324 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 472759005325 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 472759005326 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 472759005327 active site 472759005328 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 472759005329 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 472759005330 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 472759005331 dimer interface [polypeptide binding]; other site 472759005332 active site 472759005333 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 472759005334 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 472759005335 substrate binding site [chemical binding]; other site 472759005336 oxyanion hole (OAH) forming residues; other site 472759005337 trimer interface [polypeptide binding]; other site 472759005338 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 472759005339 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 472759005340 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 472759005341 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 472759005342 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 472759005343 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 472759005344 Probable transposase; Region: OrfB_IS605; pfam01385 472759005345 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 472759005346 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 472759005347 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 472759005348 OstA-like protein; Region: OstA; cl00844 472759005349 Organic solvent tolerance protein; Region: OstA_C; pfam04453 472759005350 SurA N-terminal domain; Region: SurA_N; pfam09312 472759005351 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 472759005352 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 472759005353 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 472759005354 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 472759005355 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 472759005356 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 472759005357 Maf-like protein; Region: Maf; pfam02545 472759005358 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 472759005359 active site 472759005360 dimer interface [polypeptide binding]; other site 472759005361 pyruvate carboxylase subunit B; Validated; Region: PRK09282 472759005362 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 472759005363 active site 472759005364 catalytic residues [active] 472759005365 metal binding site [ion binding]; metal-binding site 472759005366 homodimer binding site [polypeptide binding]; other site 472759005367 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 472759005368 carboxyltransferase (CT) interaction site; other site 472759005369 biotinylation site [posttranslational modification]; other site 472759005370 pyruvate carboxylase subunit A; Validated; Region: PRK07178 472759005371 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 472759005372 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 472759005373 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 472759005374 phosphoglucomutase; Region: PLN02307 472759005375 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 472759005376 substrate binding site [chemical binding]; other site 472759005377 dimer interface [polypeptide binding]; other site 472759005378 active site 472759005379 metal binding site [ion binding]; metal-binding site 472759005380 heat shock protein 90; Provisional; Region: PRK05218 472759005381 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 472759005382 ATP binding site [chemical binding]; other site 472759005383 Mg2+ binding site [ion binding]; other site 472759005384 G-X-G motif; other site 472759005385 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 472759005386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 472759005387 active site 472759005388 phosphorylation site [posttranslational modification] 472759005389 intermolecular recognition site; other site 472759005390 dimerization interface [polypeptide binding]; other site 472759005391 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 472759005392 DNA binding residues [nucleotide binding] 472759005393 dimerization interface [polypeptide binding]; other site 472759005394 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 472759005395 anti sigma factor interaction site; other site 472759005396 regulatory phosphorylation site [posttranslational modification]; other site 472759005397 Transcriptional regulator; Region: Rrf2; cl17282 472759005398 Rrf2 family protein; Region: rrf2_super; TIGR00738 472759005399 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 472759005400 Protein of unknown function, DUF482; Region: DUF482; pfam04339 472759005401 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 472759005402 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 472759005403 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 472759005404 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 472759005405 putative active site [active] 472759005406 putative metal binding site [ion binding]; other site 472759005407 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 472759005408 Protein of unknown function, DUF393; Region: DUF393; pfam04134 472759005409 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 472759005410 Uncharacterized conserved protein [Function unknown]; Region: COG3339 472759005411 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 472759005412 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 472759005413 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 472759005414 Glycerophosphodiester phosphodiesterase domain similar to Escherichia coli periplasmic phosphodiesterase (GlpQ) include uncharacterized proteins; Region: GDPD_EcGlpQ_like_1; cd08560 472759005415 putative active site [active] 472759005416 catalytic site [active] 472759005417 putative metal binding site [ion binding]; other site 472759005418 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 472759005419 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 472759005420 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 472759005421 putative dimer interface [polypeptide binding]; other site 472759005422 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 472759005423 glycerol kinase; Provisional; Region: glpK; PRK00047 472759005424 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 472759005425 N- and C-terminal domain interface [polypeptide binding]; other site 472759005426 active site 472759005427 MgATP binding site [chemical binding]; other site 472759005428 catalytic site [active] 472759005429 metal binding site [ion binding]; metal-binding site 472759005430 glycerol binding site [chemical binding]; other site 472759005431 homotetramer interface [polypeptide binding]; other site 472759005432 homodimer interface [polypeptide binding]; other site 472759005433 FBP binding site [chemical binding]; other site 472759005434 protein IIAGlc interface [polypeptide binding]; other site 472759005435 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 472759005436 Protein of unknown function (DUF3565); Region: DUF3565; pfam12088 472759005437 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 472759005438 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 472759005439 Probable Catalytic site; other site 472759005440 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 472759005441 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 472759005442 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 472759005443 trimer interface [polypeptide binding]; other site 472759005444 active site 472759005445 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 472759005446 catalytic site [active] 472759005447 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 472759005448 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 472759005449 PAS fold; Region: PAS_3; pfam08447 472759005450 putative active site [active] 472759005451 heme pocket [chemical binding]; other site 472759005452 PAS domain S-box; Region: sensory_box; TIGR00229 472759005453 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 472759005454 putative active site [active] 472759005455 heme pocket [chemical binding]; other site 472759005456 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 472759005457 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 472759005458 metal binding site [ion binding]; metal-binding site 472759005459 active site 472759005460 I-site; other site 472759005461 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 472759005462 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 472759005463 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 472759005464 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 472759005465 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 472759005466 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 472759005467 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 472759005468 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 472759005469 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 472759005470 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 472759005471 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 472759005472 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 472759005473 4Fe-4S binding domain; Region: Fer4; pfam00037 472759005474 4Fe-4S binding domain; Region: Fer4; pfam00037 472759005475 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 472759005476 NADH dehydrogenase subunit G; Validated; Region: PRK08166 472759005477 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 472759005478 catalytic loop [active] 472759005479 iron binding site [ion binding]; other site 472759005480 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 472759005481 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 472759005482 [4Fe-4S] binding site [ion binding]; other site 472759005483 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 472759005484 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 472759005485 SLBB domain; Region: SLBB; pfam10531 472759005486 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 472759005487 NADH dehydrogenase subunit E; Validated; Region: PRK07539 472759005488 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 472759005489 putative dimer interface [polypeptide binding]; other site 472759005490 [2Fe-2S] cluster binding site [ion binding]; other site 472759005491 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 472759005492 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 472759005493 NADH dehydrogenase subunit D; Validated; Region: PRK06075 472759005494 NADH dehydrogenase subunit B; Validated; Region: PRK06411 472759005495 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 472759005496 PRC-barrel domain; Region: PRC; pfam05239 472759005497 PRC-barrel domain; Region: PRC; pfam05239 472759005498 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 472759005499 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 472759005500 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 472759005501 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 472759005502 RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874 472759005503 putative active site [active] 472759005504 adenylation catalytic residue [active] 472759005505 Protein of unknown function (DUF504); Region: DUF504; pfam04457 472759005506 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222 472759005507 RNA/DNA hybrid binding site [nucleotide binding]; other site 472759005508 active site 472759005509 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 472759005510 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 472759005511 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 472759005512 tetramer interface [polypeptide binding]; other site 472759005513 TPP-binding site [chemical binding]; other site 472759005514 heterodimer interface [polypeptide binding]; other site 472759005515 phosphorylation loop region [posttranslational modification] 472759005516 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 472759005517 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 472759005518 alpha subunit interface [polypeptide binding]; other site 472759005519 TPP binding site [chemical binding]; other site 472759005520 heterodimer interface [polypeptide binding]; other site 472759005521 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 472759005522 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 472759005523 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 472759005524 E3 interaction surface; other site 472759005525 lipoyl attachment site [posttranslational modification]; other site 472759005526 e3 binding domain; Region: E3_binding; pfam02817 472759005527 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 472759005528 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 472759005529 active site 472759005530 zinc binding site [ion binding]; other site 472759005531 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 472759005532 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 472759005533 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 472759005534 motif II; other site 472759005535 inorganic pyrophosphatase; Provisional; Region: PRK00642 472759005536 dimer interface [polypeptide binding]; other site 472759005537 substrate binding site [chemical binding]; other site 472759005538 metal binding sites [ion binding]; metal-binding site 472759005539 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 472759005540 exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100 472759005541 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 472759005542 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 472759005543 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 472759005544 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 472759005545 dimer interface [polypeptide binding]; other site 472759005546 active site 472759005547 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 472759005548 catalytic residues [active] 472759005549 substrate binding site [chemical binding]; other site 472759005550 acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098 472759005551 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 472759005552 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922 472759005553 acyl-activating enzyme (AAE) consensus motif; other site 472759005554 acyl-activating enzyme (AAE) consensus motif; other site 472759005555 putative AMP binding site [chemical binding]; other site 472759005556 putative active site [active] 472759005557 putative CoA binding site [chemical binding]; other site 472759005558 probable O-glycosylation ligase, exosortase A-associated; Region: PEP_O_lig_1; TIGR03097 472759005559 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 472759005560 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 472759005561 FAD binding domain; Region: FAD_binding_4; pfam01565 472759005562 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 472759005563 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 472759005564 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 472759005565 NAD(P) binding site [chemical binding]; other site 472759005566 active site 472759005567 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 472759005568 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 472759005569 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 472759005570 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 472759005571 Ligand Binding Site [chemical binding]; other site 472759005572 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 472759005573 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 472759005574 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 472759005575 DDE superfamily endonuclease; Region: DDE_3; pfam13358 472759005576 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 472759005577 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 472759005578 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 472759005579 Predicted integral membrane protein [Function unknown]; Region: COG5652 472759005580 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 472759005581 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 472759005582 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 472759005583 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 472759005584 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 472759005585 DNA binding residues [nucleotide binding] 472759005586 Signal recognition particle GTPase [Intracellular trafficking and secretion]; Region: FtsY; COG0552 472759005587 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 472759005588 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 472759005589 P loop; other site 472759005590 GTP binding site [chemical binding]; other site 472759005591 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 472759005592 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 472759005593 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 472759005594 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 472759005595 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 472759005596 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 472759005597 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759005598 S-adenosylmethionine binding site [chemical binding]; other site 472759005599 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 472759005600 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 472759005601 active site 472759005602 (T/H)XGH motif; other site 472759005603 Ferredoxin [Energy production and conversion]; Region: COG1146 472759005604 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 472759005605 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 472759005606 active site 472759005607 catalytic tetrad [active] 472759005608 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 472759005609 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 472759005610 Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: GCD2; COG1184 472759005611 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 472759005612 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 472759005613 nudix motif; other site 472759005614 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 472759005615 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 472759005616 glycogen synthase; Provisional; Region: glgA; PRK00654 472759005617 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 472759005618 ADP-binding pocket [chemical binding]; other site 472759005619 homodimer interface [polypeptide binding]; other site 472759005620 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 472759005621 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 472759005622 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 472759005623 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 472759005624 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 472759005625 NAD binding site [chemical binding]; other site 472759005626 substrate binding site [chemical binding]; other site 472759005627 homodimer interface [polypeptide binding]; other site 472759005628 active site 472759005629 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 472759005630 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 472759005631 substrate binding site; other site 472759005632 tetramer interface; other site 472759005633 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 472759005634 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 472759005635 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 472759005636 NADP binding site [chemical binding]; other site 472759005637 active site 472759005638 putative substrate binding site [chemical binding]; other site 472759005639 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 472759005640 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 472759005641 active site 472759005642 dimer interface [polypeptide binding]; other site 472759005643 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 472759005644 Ligand Binding Site [chemical binding]; other site 472759005645 Molecular Tunnel; other site 472759005646 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 472759005647 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 472759005648 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 472759005649 Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Region: SLC5sbd_DUR3; cd11476 472759005650 Na binding site [ion binding]; other site 472759005651 Isochorismatase family; Region: Isochorismatase; pfam00857 472759005652 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 472759005653 catalytic triad [active] 472759005654 conserved cis-peptide bond; other site 472759005655 allantoate amidohydrolase; Reviewed; Region: PRK09290 472759005656 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 472759005657 active site 472759005658 metal binding site [ion binding]; metal-binding site 472759005659 dimer interface [polypeptide binding]; other site 472759005660 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 472759005661 HAMP domain; Region: HAMP; pfam00672 472759005662 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 472759005663 dimer interface [polypeptide binding]; other site 472759005664 phosphorylation site [posttranslational modification] 472759005665 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 472759005666 ATP binding site [chemical binding]; other site 472759005667 Mg2+ binding site [ion binding]; other site 472759005668 G-X-G motif; other site 472759005669 response regulator GlrR; Provisional; Region: PRK15115 472759005670 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 472759005671 active site 472759005672 phosphorylation site [posttranslational modification] 472759005673 intermolecular recognition site; other site 472759005674 dimerization interface [polypeptide binding]; other site 472759005675 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759005676 Walker A motif; other site 472759005677 ATP binding site [chemical binding]; other site 472759005678 Walker B motif; other site 472759005679 arginine finger; other site 472759005680 N-ATPase, AtpR subunit; Region: AtpR; pfam12966 472759005681 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 472759005682 Peptidase S8 family domain, uncharacterized subfamily 15; Region: Peptidases_S8_15; cd07498 472759005683 active site 472759005684 catalytic triad [active] 472759005685 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cl00365 472759005686 core domain interface [polypeptide binding]; other site 472759005687 delta subunit interface [polypeptide binding]; other site 472759005688 epsilon subunit interface [polypeptide binding]; other site 472759005689 F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343 472759005690 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 472759005691 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 472759005692 Walker A motif; other site 472759005693 ATP binding site [chemical binding]; other site 472759005694 Walker B motif; other site 472759005695 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 472759005696 alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321 472759005697 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 472759005698 F0F1 ATP synthase subunit C; Provisional; Region: PRK13468 472759005699 F0F1 ATP synthase subunit A; Provisional; Region: PRK13420 472759005700 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 472759005701 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cl10033 472759005702 LBP interface [polypeptide binding]; other site 472759005703 epsilon subunit interface [polypeptide binding]; other site 472759005704 gamma subunit interface [polypeptide binding]; other site 472759005705 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 472759005706 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 472759005707 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 472759005708 alpha subunit interaction interface [polypeptide binding]; other site 472759005709 Walker A motif; other site 472759005710 ATP binding site [chemical binding]; other site 472759005711 Walker B motif; other site 472759005712 inhibitor binding site; inhibition site 472759005713 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 472759005714 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 472759005715 30S subunit binding site; other site 472759005716 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 472759005717 DNA-binding site [nucleotide binding]; DNA binding site 472759005718 RNA-binding motif; other site 472759005719 Haemolytic domain; Region: Haemolytic; pfam01809 472759005720 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 472759005721 MerR family regulatory protein; Region: MerR; pfam00376 472759005722 DNA binding residues [nucleotide binding] 472759005723 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 472759005724 catalytic residues [active] 472759005725 catalytic nucleophile [active] 472759005726 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 472759005727 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 472759005728 Peptidase family M23; Region: Peptidase_M23; pfam01551 472759005729 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 472759005730 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 472759005731 Walker A/P-loop; other site 472759005732 ATP binding site [chemical binding]; other site 472759005733 Q-loop/lid; other site 472759005734 ABC transporter signature motif; other site 472759005735 Walker B; other site 472759005736 D-loop; other site 472759005737 H-loop/switch region; other site 472759005738 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 472759005739 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 472759005740 HlyD family secretion protein; Region: HlyD_3; pfam13437 472759005741 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 472759005742 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 472759005743 ProQ/FINO family; Region: ProQ; pfam04352 472759005744 YcfA-like protein; Region: YcfA; cl00752 472759005745 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 472759005746 Phosphotransferase enzyme family; Region: APH; pfam01636 472759005747 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 472759005748 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 472759005749 Substrate binding site; other site 472759005750 metal-binding site 472759005751 ornithine carbamoyltransferase; Provisional; Region: PRK00779 472759005752 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 472759005753 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 472759005754 acetylornithine aminotransferase; Provisional; Region: PRK02627 472759005755 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 472759005756 inhibitor-cofactor binding pocket; inhibition site 472759005757 pyridoxal 5'-phosphate binding site [chemical binding]; other site 472759005758 catalytic residue [active] 472759005759 superoxide dismutase; Provisional; Region: PRK10543 472759005760 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 472759005761 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 472759005762 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 472759005763 putative GSH binding site [chemical binding]; other site 472759005764 catalytic residues [active] 472759005765 Uncharacterized conserved protein [Function unknown]; Region: COG2127 472759005766 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 472759005767 Clp amino terminal domain; Region: Clp_N; pfam02861 472759005768 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759005769 Walker A motif; other site 472759005770 ATP binding site [chemical binding]; other site 472759005771 Walker B motif; other site 472759005772 arginine finger; other site 472759005773 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759005774 Walker A motif; other site 472759005775 ATP binding site [chemical binding]; other site 472759005776 Walker B motif; other site 472759005777 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 472759005778 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 472759005779 metal binding site 2 [ion binding]; metal-binding site 472759005780 putative DNA binding helix; other site 472759005781 metal binding site 1 [ion binding]; metal-binding site 472759005782 dimer interface [polypeptide binding]; other site 472759005783 structural Zn2+ binding site [ion binding]; other site 472759005784 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018 472759005785 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 472759005786 putative metal binding residues [ion binding]; other site 472759005787 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 472759005788 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 472759005789 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 472759005790 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 472759005791 ABC-ATPase subunit interface; other site 472759005792 dimer interface [polypeptide binding]; other site 472759005793 Domain of unknown function DUF29; Region: DUF29; pfam01724 472759005794 ERCC4 domain; Region: ERCC4; smart00891 472759005795 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 472759005796 DNA binding site [nucleotide binding] 472759005797 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 472759005798 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 472759005799 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 472759005800 dimer interface [polypeptide binding]; other site 472759005801 ADP-ribose binding site [chemical binding]; other site 472759005802 active site 472759005803 nudix motif; other site 472759005804 metal binding site [ion binding]; metal-binding site 472759005805 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 472759005806 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 472759005807 active site 472759005808 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 472759005809 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 472759005810 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 472759005811 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 472759005812 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 472759005813 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 472759005814 active site 472759005815 phosphorylation site [posttranslational modification] 472759005816 intermolecular recognition site; other site 472759005817 dimerization interface [polypeptide binding]; other site 472759005818 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 472759005819 DNA binding site [nucleotide binding] 472759005820 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 472759005821 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 472759005822 PAS domain; Region: PAS; smart00091 472759005823 putative active site [active] 472759005824 heme pocket [chemical binding]; other site 472759005825 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 472759005826 dimer interface [polypeptide binding]; other site 472759005827 phosphorylation site [posttranslational modification] 472759005828 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 472759005829 ATP binding site [chemical binding]; other site 472759005830 Mg2+ binding site [ion binding]; other site 472759005831 G-X-G motif; other site 472759005832 PBP superfamily domain; Region: PBP_like_2; cl17296 472759005833 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 472759005834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 472759005835 conserved gate region; other site 472759005836 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 472759005837 dimer interface [polypeptide binding]; other site 472759005838 conserved gate region; other site 472759005839 putative PBP binding loops; other site 472759005840 ABC-ATPase subunit interface; other site 472759005841 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 472759005842 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 472759005843 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 472759005844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 472759005845 dimer interface [polypeptide binding]; other site 472759005846 conserved gate region; other site 472759005847 putative PBP binding loops; other site 472759005848 ABC-ATPase subunit interface; other site 472759005849 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 472759005850 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 472759005851 Walker A/P-loop; other site 472759005852 ATP binding site [chemical binding]; other site 472759005853 Q-loop/lid; other site 472759005854 ABC transporter signature motif; other site 472759005855 Walker B; other site 472759005856 D-loop; other site 472759005857 H-loop/switch region; other site 472759005858 transcriptional regulator PhoU; Provisional; Region: PRK11115 472759005859 PhoU domain; Region: PhoU; pfam01895 472759005860 PhoU domain; Region: PhoU; pfam01895 472759005861 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 472759005862 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 472759005863 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 472759005864 putative active site [active] 472759005865 putative metal binding residues [ion binding]; other site 472759005866 signature motif; other site 472759005867 putative triphosphate binding site [ion binding]; other site 472759005868 Domain of unknown function (DUF1902); Region: DUF1902; pfam08972 472759005869 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 472759005870 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 472759005871 active site 472759005872 motif I; other site 472759005873 motif II; other site 472759005874 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 472759005875 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 472759005876 DNA protecting protein DprA; Region: dprA; TIGR00732 472759005877 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 472759005878 Methyltransferase domain; Region: Methyltransf_31; pfam13847 472759005879 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759005880 S-adenosylmethionine binding site [chemical binding]; other site 472759005881 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 472759005882 polyphosphate kinase; Provisional; Region: PRK05443 472759005883 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 472759005884 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 472759005885 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 472759005886 putative domain interface [polypeptide binding]; other site 472759005887 putative active site [active] 472759005888 catalytic site [active] 472759005889 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 472759005890 putative domain interface [polypeptide binding]; other site 472759005891 putative active site [active] 472759005892 catalytic site [active] 472759005893 BolA-like protein; Region: BolA; pfam01722 472759005894 YciI-like protein; Reviewed; Region: PRK11370 472759005895 intracellular septation protein A; Reviewed; Region: PRK00259 472759005896 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 472759005897 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 472759005898 active site 472759005899 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 472759005900 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 472759005901 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 472759005902 putative acyl-acceptor binding pocket; other site 472759005903 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 472759005904 Clp amino terminal domain; Region: Clp_N; pfam02861 472759005905 Clp amino terminal domain; Region: Clp_N; pfam02861 472759005906 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759005907 Walker A motif; other site 472759005908 ATP binding site [chemical binding]; other site 472759005909 Walker B motif; other site 472759005910 arginine finger; other site 472759005911 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759005912 Walker A motif; other site 472759005913 ATP binding site [chemical binding]; other site 472759005914 Walker B motif; other site 472759005915 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 472759005916 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 472759005917 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 472759005918 active site clefts [active] 472759005919 zinc binding site [ion binding]; other site 472759005920 dimer interface [polypeptide binding]; other site 472759005921 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 472759005922 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 472759005923 putative acyl-acceptor binding pocket; other site 472759005924 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 472759005925 acyl-activating enzyme (AAE) consensus motif; other site 472759005926 putative AMP binding site [chemical binding]; other site 472759005927 Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247 472759005928 short chain dehydrogenase; Provisional; Region: PRK05993 472759005929 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 472759005930 NADP binding site [chemical binding]; other site 472759005931 active site 472759005932 steroid binding site; other site 472759005933 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 472759005934 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 472759005935 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 472759005936 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 472759005937 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK12634 472759005938 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 472759005939 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 472759005940 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 472759005941 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 472759005942 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 472759005943 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 472759005944 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 472759005945 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 472759005946 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 472759005947 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 472759005948 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 472759005949 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 472759005950 Flagellar L-ring protein; Region: FlgH; pfam02107 472759005951 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 472759005952 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 472759005953 Rod binding protein; Region: Rod-binding; cl01626 472759005954 flagellar rod assembly protein/muramidase FlgJ; Region: flagell_FlgJ; TIGR02541 472759005955 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 472759005956 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945 472759005957 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 472759005958 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 472759005959 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 472759005960 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 472759005961 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 472759005962 flagellin; Provisional; Region: PRK12806 472759005963 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 472759005964 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 472759005965 FlaG protein; Region: FlaG; pfam03646 472759005966 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 472759005967 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 472759005968 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 472759005969 flagellar protein FliS; Validated; Region: fliS; PRK05685 472759005970 Flagellar protein FliT; Region: FliT; pfam05400 472759005971 PilZ domain; Region: PilZ; cl01260 472759005972 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 472759005973 Flagellar regulatory protein FleQ; Region: FleQ; pfam06490 472759005974 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759005975 Walker A motif; other site 472759005976 ATP binding site [chemical binding]; other site 472759005977 Walker B motif; other site 472759005978 arginine finger; other site 472759005979 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 472759005980 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 472759005981 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759005982 Walker A motif; other site 472759005983 ATP binding site [chemical binding]; other site 472759005984 Walker B motif; other site 472759005985 arginine finger; other site 472759005986 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 472759005987 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 472759005988 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 472759005989 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 472759005990 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 472759005991 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 472759005992 FliG C-terminal domain; Region: FliG_C; pfam01706 472759005993 flagellar assembly protein H; Validated; Region: fliH; PRK05687 472759005994 Flagellar assembly protein FliH; Region: FliH; pfam02108 472759005995 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 472759005996 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 472759005997 Walker A motif/ATP binding site; other site 472759005998 Walker B motif; other site 472759005999 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 472759006000 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 472759006001 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 472759006002 active site 472759006003 dimer interface [polypeptide binding]; other site 472759006004 Predicted transcriptional regulator [Transcription]; Region: COG2944 472759006005 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 472759006006 non-specific DNA binding site [nucleotide binding]; other site 472759006007 salt bridge; other site 472759006008 sequence-specific DNA binding site [nucleotide binding]; other site 472759006009 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 472759006010 Uncharacterized conserved protein [Function unknown]; Region: COG1262 472759006011 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 472759006012 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 472759006013 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 472759006014 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 472759006015 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 472759006016 active site 472759006017 NTP binding site [chemical binding]; other site 472759006018 metal binding triad [ion binding]; metal-binding site 472759006019 antibiotic binding site [chemical binding]; other site 472759006020 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 472759006021 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 472759006022 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 472759006023 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 472759006024 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 472759006025 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 472759006026 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 472759006027 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 472759006028 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 472759006029 Protein export membrane protein; Region: SecD_SecF; pfam02355 472759006030 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 472759006031 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 472759006032 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 472759006033 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 472759006034 aromatic acid decarboxylase; Validated; Region: PRK05920 472759006035 Flavoprotein; Region: Flavoprotein; pfam02441 472759006036 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 472759006037 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 472759006038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 472759006039 SCP-2 sterol transfer family; Region: SCP2; pfam02036 472759006040 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 472759006041 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759006042 S-adenosylmethionine binding site [chemical binding]; other site 472759006043 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 472759006044 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 472759006045 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759006046 Walker A motif; other site 472759006047 ATP binding site [chemical binding]; other site 472759006048 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 472759006049 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 472759006050 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 472759006051 active site 472759006052 HslU subunit interaction site [polypeptide binding]; other site 472759006053 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 472759006054 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 472759006055 NAD binding site [chemical binding]; other site 472759006056 homodimer interface [polypeptide binding]; other site 472759006057 active site 472759006058 substrate binding site [chemical binding]; other site 472759006059 elongation factor Tu; Reviewed; Region: PRK00049 472759006060 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 472759006061 G1 box; other site 472759006062 GEF interaction site [polypeptide binding]; other site 472759006063 GTP/Mg2+ binding site [chemical binding]; other site 472759006064 Switch I region; other site 472759006065 G2 box; other site 472759006066 G3 box; other site 472759006067 Switch II region; other site 472759006068 G4 box; other site 472759006069 G5 box; other site 472759006070 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 472759006071 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 472759006072 Antibiotic Binding Site [chemical binding]; other site 472759006073 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 472759006074 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 472759006075 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 472759006076 putative homodimer interface [polypeptide binding]; other site 472759006077 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 472759006078 heterodimer interface [polypeptide binding]; other site 472759006079 homodimer interface [polypeptide binding]; other site 472759006080 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 472759006081 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 472759006082 23S rRNA interface [nucleotide binding]; other site 472759006083 L7/L12 interface [polypeptide binding]; other site 472759006084 putative thiostrepton binding site; other site 472759006085 L25 interface [polypeptide binding]; other site 472759006086 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 472759006087 mRNA/rRNA interface [nucleotide binding]; other site 472759006088 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 472759006089 23S rRNA interface [nucleotide binding]; other site 472759006090 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 472759006091 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 472759006092 peripheral dimer interface [polypeptide binding]; other site 472759006093 core dimer interface [polypeptide binding]; other site 472759006094 L10 interface [polypeptide binding]; other site 472759006095 L11 interface [polypeptide binding]; other site 472759006096 putative EF-Tu interaction site [polypeptide binding]; other site 472759006097 putative EF-G interaction site [polypeptide binding]; other site 472759006098 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 472759006099 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 472759006100 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 472759006101 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 472759006102 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 472759006103 RPB12 interaction site [polypeptide binding]; other site 472759006104 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 472759006105 RPB3 interaction site [polypeptide binding]; other site 472759006106 RPB1 interaction site [polypeptide binding]; other site 472759006107 RPB11 interaction site [polypeptide binding]; other site 472759006108 RPB10 interaction site [polypeptide binding]; other site 472759006109 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 472759006110 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 472759006111 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 472759006112 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 472759006113 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 472759006114 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 472759006115 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 472759006116 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 472759006117 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 472759006118 DNA binding site [nucleotide binding] 472759006119 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 472759006120 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 472759006121 S17 interaction site [polypeptide binding]; other site 472759006122 S8 interaction site; other site 472759006123 16S rRNA interaction site [nucleotide binding]; other site 472759006124 streptomycin interaction site [chemical binding]; other site 472759006125 23S rRNA interaction site [nucleotide binding]; other site 472759006126 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 472759006127 30S ribosomal protein S7; Validated; Region: PRK05302 472759006128 elongation factor G; Reviewed; Region: PRK00007 472759006129 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 472759006130 G1 box; other site 472759006131 putative GEF interaction site [polypeptide binding]; other site 472759006132 GTP/Mg2+ binding site [chemical binding]; other site 472759006133 Switch I region; other site 472759006134 G2 box; other site 472759006135 G3 box; other site 472759006136 Switch II region; other site 472759006137 G4 box; other site 472759006138 G5 box; other site 472759006139 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 472759006140 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 472759006141 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 472759006142 elongation factor Tu; Reviewed; Region: PRK00049 472759006143 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 472759006144 G1 box; other site 472759006145 GEF interaction site [polypeptide binding]; other site 472759006146 GTP/Mg2+ binding site [chemical binding]; other site 472759006147 Switch I region; other site 472759006148 G2 box; other site 472759006149 G3 box; other site 472759006150 Switch II region; other site 472759006151 G4 box; other site 472759006152 G5 box; other site 472759006153 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 472759006154 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 472759006155 Antibiotic Binding Site [chemical binding]; other site 472759006156 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 472759006157 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 472759006158 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 472759006159 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 472759006160 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 472759006161 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 472759006162 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 472759006163 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 472759006164 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 472759006165 putative translocon binding site; other site 472759006166 protein-rRNA interface [nucleotide binding]; other site 472759006167 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 472759006168 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 472759006169 G-X-X-G motif; other site 472759006170 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 472759006171 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 472759006172 23S rRNA interface [nucleotide binding]; other site 472759006173 5S rRNA interface [nucleotide binding]; other site 472759006174 putative antibiotic binding site [chemical binding]; other site 472759006175 L25 interface [polypeptide binding]; other site 472759006176 L27 interface [polypeptide binding]; other site 472759006177 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 472759006178 23S rRNA interface [nucleotide binding]; other site 472759006179 putative translocon interaction site; other site 472759006180 signal recognition particle (SRP54) interaction site; other site 472759006181 L23 interface [polypeptide binding]; other site 472759006182 trigger factor interaction site; other site 472759006183 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 472759006184 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 472759006185 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 472759006186 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 472759006187 RNA binding site [nucleotide binding]; other site 472759006188 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 472759006189 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 472759006190 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 472759006191 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 472759006192 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 472759006193 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 472759006194 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 472759006195 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 472759006196 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 472759006197 23S rRNA interface [nucleotide binding]; other site 472759006198 L21e interface [polypeptide binding]; other site 472759006199 5S rRNA interface [nucleotide binding]; other site 472759006200 L27 interface [polypeptide binding]; other site 472759006201 L5 interface [polypeptide binding]; other site 472759006202 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 472759006203 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 472759006204 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 472759006205 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 472759006206 23S rRNA binding site [nucleotide binding]; other site 472759006207 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 472759006208 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 472759006209 SecY translocase; Region: SecY; pfam00344 472759006210 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 472759006211 30S ribosomal protein S13; Region: bact_S13; TIGR03631 472759006212 30S ribosomal protein S11; Validated; Region: PRK05309 472759006213 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 472759006214 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 472759006215 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 472759006216 RNA binding surface [nucleotide binding]; other site 472759006217 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 472759006218 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 472759006219 alphaNTD homodimer interface [polypeptide binding]; other site 472759006220 alphaNTD - beta interaction site [polypeptide binding]; other site 472759006221 alphaNTD - beta' interaction site [polypeptide binding]; other site 472759006222 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 472759006223 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 472759006224 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 472759006225 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 472759006226 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759006227 S-adenosylmethionine binding site [chemical binding]; other site 472759006228 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 472759006229 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 472759006230 active site 472759006231 putative substrate binding pocket [chemical binding]; other site 472759006232 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 472759006233 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 472759006234 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684 472759006235 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 472759006236 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 472759006237 substrate binding site [chemical binding]; other site 472759006238 dimerization interface [polypeptide binding]; other site 472759006239 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 472759006240 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 472759006241 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 472759006242 Active Sites [active] 472759006243 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 472759006244 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 472759006245 Active Sites [active] 472759006246 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 472759006247 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 472759006248 CysD dimerization site [polypeptide binding]; other site 472759006249 G1 box; other site 472759006250 putative GEF interaction site [polypeptide binding]; other site 472759006251 GTP/Mg2+ binding site [chemical binding]; other site 472759006252 Switch I region; other site 472759006253 G2 box; other site 472759006254 G3 box; other site 472759006255 Switch II region; other site 472759006256 G4 box; other site 472759006257 G5 box; other site 472759006258 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 472759006259 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 472759006260 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_6; cd06256 472759006261 putative active site [active] 472759006262 Zn binding site [ion binding]; other site 472759006263 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 472759006264 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 472759006265 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 472759006266 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 472759006267 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 472759006268 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 472759006269 ATP binding site [chemical binding]; other site 472759006270 Mg2+ binding site [ion binding]; other site 472759006271 G-X-G motif; other site 472759006272 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 472759006273 anchoring element; other site 472759006274 dimer interface [polypeptide binding]; other site 472759006275 ATP binding site [chemical binding]; other site 472759006276 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 472759006277 active site 472759006278 metal binding site [ion binding]; metal-binding site 472759006279 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 472759006280 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 472759006281 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 472759006282 CAP-like domain; other site 472759006283 active site 472759006284 primary dimer interface [polypeptide binding]; other site 472759006285 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 472759006286 CoA binding domain; Region: CoA_binding; cl17356 472759006287 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 472759006288 NAD(P) binding site [chemical binding]; other site 472759006289 homodimer interface [polypeptide binding]; other site 472759006290 substrate binding site [chemical binding]; other site 472759006291 active site 472759006292 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 472759006293 active site 472759006294 tetramer interface; other site 472759006295 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 472759006296 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082 472759006297 putative dimer interface [polypeptide binding]; other site 472759006298 [2Fe-2S] cluster binding site [ion binding]; other site 472759006299 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 472759006300 SLBB domain; Region: SLBB; pfam10531 472759006301 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 472759006302 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 472759006303 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 472759006304 catalytic loop [active] 472759006305 iron binding site [ion binding]; other site 472759006306 4Fe-4S binding domain; Region: Fer4; pfam00037 472759006307 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 472759006308 [4Fe-4S] binding site [ion binding]; other site 472759006309 molybdopterin cofactor binding site; other site 472759006310 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 472759006311 molybdopterin cofactor binding site; other site 472759006312 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 472759006313 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 472759006314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759006315 S-adenosylmethionine binding site [chemical binding]; other site 472759006316 Predicted membrane protein [Function unknown]; Region: COG1238 472759006317 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 472759006318 Peptidase family M23; Region: Peptidase_M23; pfam01551 472759006319 peptide chain release factor 2; Validated; Region: prfB; PRK00578 472759006320 This domain is found in peptide chain release factors; Region: PCRF; smart00937 472759006321 RF-1 domain; Region: RF-1; pfam00472 472759006322 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 472759006323 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 472759006324 dimer interface [polypeptide binding]; other site 472759006325 putative anticodon binding site; other site 472759006326 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 472759006327 motif 1; other site 472759006328 active site 472759006329 motif 2; other site 472759006330 motif 3; other site 472759006331 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 472759006332 Recombination protein O N terminal; Region: RecO_N; pfam11967 472759006333 Recombination protein O C terminal; Region: RecO_C; pfam02565 472759006334 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 472759006335 active site 472759006336 hydrophilic channel; other site 472759006337 dimerization interface [polypeptide binding]; other site 472759006338 catalytic residues [active] 472759006339 active site lid [active] 472759006340 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 472759006341 cysteine synthase B; Region: cysM; TIGR01138 472759006342 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 472759006343 dimer interface [polypeptide binding]; other site 472759006344 pyridoxal 5'-phosphate binding site [chemical binding]; other site 472759006345 catalytic residue [active] 472759006346 Protein of unknown function (DUF1318); Region: DUF1318; cl01547 472759006347 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 472759006348 active site 472759006349 catalytic site [active] 472759006350 substrate binding site [chemical binding]; other site 472759006351 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 472759006352 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 472759006353 TRAM domain; Region: TRAM; pfam01938 472759006354 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759006355 S-adenosylmethionine binding site [chemical binding]; other site 472759006356 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 472759006357 homopentamer interface [polypeptide binding]; other site 472759006358 active site 472759006359 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 472759006360 putative RNA binding site [nucleotide binding]; other site 472759006361 thiamine monophosphate kinase; Provisional; Region: PRK05731 472759006362 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 472759006363 ATP binding site [chemical binding]; other site 472759006364 dimerization interface [polypeptide binding]; other site 472759006365 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 472759006366 tetramer interfaces [polypeptide binding]; other site 472759006367 binuclear metal-binding site [ion binding]; other site 472759006368 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 472759006369 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 472759006370 metal binding triad; other site 472759006371 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 472759006372 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 472759006373 Zn2+ binding site [ion binding]; other site 472759006374 Mg2+ binding site [ion binding]; other site 472759006375 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 472759006376 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 472759006377 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 472759006378 active site 472759006379 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 472759006380 rRNA interaction site [nucleotide binding]; other site 472759006381 S8 interaction site; other site 472759006382 elongation factor Ts; Provisional; Region: tsf; PRK09377 472759006383 UBA/TS-N domain; Region: UBA; pfam00627 472759006384 Elongation factor TS; Region: EF_TS; pfam00889 472759006385 Elongation factor TS; Region: EF_TS; pfam00889 472759006386 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 472759006387 putative nucleotide binding site [chemical binding]; other site 472759006388 uridine monophosphate binding site [chemical binding]; other site 472759006389 homohexameric interface [polypeptide binding]; other site 472759006390 ribosome recycling factor; Reviewed; Region: frr; PRK00083 472759006391 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 472759006392 hinge region; other site 472759006393 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 472759006394 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 472759006395 catalytic residue [active] 472759006396 putative FPP diphosphate binding site; other site 472759006397 putative FPP binding hydrophobic cleft; other site 472759006398 dimer interface [polypeptide binding]; other site 472759006399 putative IPP diphosphate binding site; other site 472759006400 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 472759006401 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 472759006402 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 472759006403 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 472759006404 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 472759006405 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 472759006406 zinc metallopeptidase RseP; Provisional; Region: PRK10779 472759006407 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 472759006408 active site 472759006409 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 472759006410 protein binding site [polypeptide binding]; other site 472759006411 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 472759006412 protein binding site [polypeptide binding]; other site 472759006413 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 472759006414 putative substrate binding region [chemical binding]; other site 472759006415 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 472759006416 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 472759006417 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 472759006418 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 472759006419 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 472759006420 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 472759006421 Surface antigen; Region: Bac_surface_Ag; pfam01103 472759006422 periplasmic chaperone; Provisional; Region: PRK10780 472759006423 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 472759006424 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 472759006425 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 472759006426 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 472759006427 active site 472759006428 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 472759006429 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 472759006430 TPR motif; other site 472759006431 binding surface 472759006432 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 472759006433 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 472759006434 Trp docking motif [polypeptide binding]; other site 472759006435 Probable transposase; Region: OrfB_IS605; pfam01385 472759006436 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 472759006437 GTP-binding protein Der; Reviewed; Region: PRK00093 472759006438 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 472759006439 G1 box; other site 472759006440 GTP/Mg2+ binding site [chemical binding]; other site 472759006441 Switch I region; other site 472759006442 G2 box; other site 472759006443 Switch II region; other site 472759006444 G3 box; other site 472759006445 G4 box; other site 472759006446 G5 box; other site 472759006447 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 472759006448 G1 box; other site 472759006449 GTP/Mg2+ binding site [chemical binding]; other site 472759006450 Switch I region; other site 472759006451 G2 box; other site 472759006452 G3 box; other site 472759006453 Switch II region; other site 472759006454 G4 box; other site 472759006455 G5 box; other site 472759006456 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 472759006457 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 472759006458 dimer interface [polypeptide binding]; other site 472759006459 putative functional site; other site 472759006460 putative MPT binding site; other site 472759006461 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 472759006462 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 472759006463 GTP binding site; other site 472759006464 Ferritin-like domain; Region: Ferritin; pfam00210 472759006465 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 472759006466 dinuclear metal binding motif [ion binding]; other site 472759006467 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 472759006468 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 472759006469 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 472759006470 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 472759006471 CBS domain; Region: CBS; pfam00571 472759006472 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 472759006473 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 472759006474 ligand binding site [chemical binding]; other site 472759006475 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 472759006476 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 472759006477 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 472759006478 acyl-activating enzyme (AAE) consensus motif; other site 472759006479 putative AMP binding site [chemical binding]; other site 472759006480 putative active site [active] 472759006481 putative CoA binding site [chemical binding]; other site 472759006482 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 472759006483 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 472759006484 substrate binding site [chemical binding]; other site 472759006485 oxyanion hole (OAH) forming residues; other site 472759006486 trimer interface [polypeptide binding]; other site 472759006487 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 472759006488 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 472759006489 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 472759006490 acetyl-CoA acetyltransferase; Provisional; Region: PRK08170 472759006491 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 472759006492 dimer interface [polypeptide binding]; other site 472759006493 active site 472759006494 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 472759006495 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 472759006496 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 472759006497 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 472759006498 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 472759006499 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 472759006500 putative DNA binding site [nucleotide binding]; other site 472759006501 putative homodimer interface [polypeptide binding]; other site 472759006502 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 472759006503 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 472759006504 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 472759006505 catalytic residue [active] 472759006506 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 472759006507 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 472759006508 glycogen branching enzyme; Provisional; Region: PRK12313 472759006509 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 472759006510 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 472759006511 active site 472759006512 catalytic site [active] 472759006513 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 472759006514 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 472759006515 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 472759006516 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 472759006517 active site 472759006518 homodimer interface [polypeptide binding]; other site 472759006519 catalytic site [active] 472759006520 acceptor binding site [chemical binding]; other site 472759006521 trehalose synthase; Region: treS_nterm; TIGR02456 472759006522 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 472759006523 active site 472759006524 catalytic site [active] 472759006525 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 472759006526 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 472759006527 Cupin domain; Region: Cupin_2; pfam07883 472759006528 intracellular protease, PfpI family; Region: PfpI; TIGR01382 472759006529 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 472759006530 conserved cys residue [active] 472759006531 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 472759006532 B12 binding site [chemical binding]; other site 472759006533 cobalt ligand [ion binding]; other site 472759006534 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 472759006535 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 472759006536 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 472759006537 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 472759006538 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 472759006539 dimer interface [polypeptide binding]; other site 472759006540 active site 472759006541 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 472759006542 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 472759006543 enoyl-CoA hydratase; Provisional; Region: PRK05995 472759006544 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 472759006545 substrate binding site [chemical binding]; other site 472759006546 oxyanion hole (OAH) forming residues; other site 472759006547 trimer interface [polypeptide binding]; other site 472759006548 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 472759006549 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 472759006550 active site 472759006551 catalytic residues [active] 472759006552 metal binding site [ion binding]; metal-binding site 472759006553 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 472759006554 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 472759006555 Probable transposase; Region: OrfB_IS605; pfam01385 472759006556 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 472759006557 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 472759006558 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 472759006559 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 472759006560 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 472759006561 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 472759006562 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 472759006563 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 472759006564 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 472759006565 acyl-activating enzyme (AAE) consensus motif; other site 472759006566 putative AMP binding site [chemical binding]; other site 472759006567 putative active site [active] 472759006568 putative CoA binding site [chemical binding]; other site 472759006569 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 472759006570 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 472759006571 NADP binding site [chemical binding]; other site 472759006572 dimer interface [polypeptide binding]; other site 472759006573 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 472759006574 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 472759006575 active site 472759006576 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 472759006577 SEC-C motif; Region: SEC-C; pfam02810 472759006578 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 472759006579 HSP70 interaction site [polypeptide binding]; other site 472759006580 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 472759006581 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 472759006582 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 472759006583 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 472759006584 nucleotide binding site [chemical binding]; other site 472759006585 putative NEF/HSP70 interaction site [polypeptide binding]; other site 472759006586 SBD interface [polypeptide binding]; other site 472759006587 YcfA-like protein; Region: YcfA; pfam07927 472759006588 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 472759006589 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 472759006590 non-specific DNA binding site [nucleotide binding]; other site 472759006591 salt bridge; other site 472759006592 sequence-specific DNA binding site [nucleotide binding]; other site 472759006593 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 472759006594 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 472759006595 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 472759006596 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 472759006597 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 472759006598 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 472759006599 putative active site [active] 472759006600 PhoH-like protein; Region: PhoH; pfam02562 472759006601 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 472759006602 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 472759006603 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 472759006604 substrate binding pocket [chemical binding]; other site 472759006605 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 472759006606 B12 binding site [chemical binding]; other site 472759006607 cobalt ligand [ion binding]; other site 472759006608 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 472759006609 isocitrate dehydrogenase; Validated; Region: PRK07362 472759006610 isocitrate dehydrogenase; Reviewed; Region: PRK07006 472759006611 Methyltransferase domain; Region: Methyltransf_23; pfam13489 472759006612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759006613 S-adenosylmethionine binding site [chemical binding]; other site 472759006614 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 472759006615 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 472759006616 Uncharacterized conserved protein [Function unknown]; Region: COG5316 472759006617 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 472759006618 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 472759006619 substrate binding site [chemical binding]; other site 472759006620 THF binding site; other site 472759006621 zinc-binding site [ion binding]; other site 472759006622 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 472759006623 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 472759006624 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 472759006625 putative ADP-binding pocket [chemical binding]; other site 472759006626 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 472759006627 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 472759006628 putative dimer interface [polypeptide binding]; other site 472759006629 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 472759006630 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 472759006631 putative dimer interface [polypeptide binding]; other site 472759006632 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 472759006633 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 472759006634 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 472759006635 ABC transporter; Region: ABC_tran_2; pfam12848 472759006636 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 472759006637 methionine sulfoxide reductase B; Provisional; Region: PRK00222 472759006638 SelR domain; Region: SelR; pfam01641 472759006639 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 472759006640 ApbE family; Region: ApbE; pfam02424 472759006641 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 472759006642 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 472759006643 YcgL domain; Region: YcgL; pfam05166 472759006644 FOG: WD40 repeat [General function prediction only]; Region: COG2319 472759006645 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 472759006646 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 472759006647 Mechanosensitive ion channel; Region: MS_channel; pfam00924 472759006648 Domain of unknown function (DUF4071); Region: DUF4071; pfam13281 472759006649 Predicted metal-binding protein [General function prediction only]; Region: COG3019 472759006650 Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916 472759006651 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 472759006652 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759006653 Walker A motif; other site 472759006654 ATP binding site [chemical binding]; other site 472759006655 Walker B motif; other site 472759006656 arginine finger; other site 472759006657 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 472759006658 Family description; Region: DsbD_2; pfam13386 472759006659 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 472759006660 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 472759006661 Walker A/P-loop; other site 472759006662 ATP binding site [chemical binding]; other site 472759006663 Q-loop/lid; other site 472759006664 ABC transporter signature motif; other site 472759006665 Walker B; other site 472759006666 D-loop; other site 472759006667 H-loop/switch region; other site 472759006668 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 472759006669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 472759006670 dimer interface [polypeptide binding]; other site 472759006671 conserved gate region; other site 472759006672 ABC-ATPase subunit interface; other site 472759006673 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 472759006674 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 472759006675 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 472759006676 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 472759006677 putative ADP-binding pocket [chemical binding]; other site 472759006678 hypothetical protein; Provisional; Region: PRK07907 472759006679 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 472759006680 metal binding site [ion binding]; metal-binding site 472759006681 putative dimer interface [polypeptide binding]; other site 472759006682 Peptidase family M48; Region: Peptidase_M48; cl12018 472759006683 TPR repeat; Region: TPR_11; pfam13414 472759006684 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 472759006685 TPR motif; other site 472759006686 binding surface 472759006687 Tetratricopeptide repeat; Region: TPR_12; pfam13424 472759006688 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 472759006689 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 472759006690 putative active site [active] 472759006691 putative metal binding site [ion binding]; other site 472759006692 Putative integral membrane protein DUF46; Region: DUF46; cl17511 472759006693 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 472759006694 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 472759006695 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 472759006696 FtsX-like permease family; Region: FtsX; pfam02687 472759006697 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 472759006698 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 472759006699 Walker A/P-loop; other site 472759006700 ATP binding site [chemical binding]; other site 472759006701 Q-loop/lid; other site 472759006702 ABC transporter signature motif; other site 472759006703 Walker B; other site 472759006704 D-loop; other site 472759006705 H-loop/switch region; other site 472759006706 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 472759006707 active site 472759006708 catalytic triad [active] 472759006709 oxyanion hole [active] 472759006710 switch loop; other site 472759006711 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 472759006712 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 472759006713 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 472759006714 Protein of unknown function DUF99; Region: DUF99; pfam01949 472759006715 hypothetical protein; Provisional; Region: PRK00766 472759006716 HEAT repeats; Region: HEAT_2; pfam13646 472759006717 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 472759006718 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 472759006719 catalytic residues [active] 472759006720 Domain of unknown function (DUF4266); Region: DUF4266; pfam14086 472759006721 Protein of unknown function (DUF3570); Region: DUF3570; pfam12094 472759006722 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 472759006723 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 472759006724 ApbE family; Region: ApbE; pfam02424 472759006725 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 472759006726 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 472759006727 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 472759006728 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 472759006729 Walker A/P-loop; other site 472759006730 ATP binding site [chemical binding]; other site 472759006731 Q-loop/lid; other site 472759006732 ABC transporter signature motif; other site 472759006733 Walker B; other site 472759006734 D-loop; other site 472759006735 H-loop/switch region; other site 472759006736 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 472759006737 putative carbohydrate binding site [chemical binding]; other site 472759006738 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 472759006739 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 472759006740 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 472759006741 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 472759006742 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473 472759006743 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 472759006744 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 472759006745 metal-binding site 472759006746 Methyltransferase domain; Region: Methyltransf_23; pfam13489 472759006747 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759006748 S-adenosylmethionine binding site [chemical binding]; other site 472759006749 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 472759006750 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 472759006751 metal-binding site 472759006752 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 472759006753 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 472759006754 metal-binding site 472759006755 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 472759006756 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 472759006757 putative ADP-binding pocket [chemical binding]; other site 472759006758 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 472759006759 heme-binding residues [chemical binding]; other site 472759006760 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 472759006761 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 472759006762 molybdopterin cofactor binding site; other site 472759006763 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 472759006764 4Fe-4S binding domain; Region: Fer4_2; pfam12797 472759006765 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 472759006766 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 472759006767 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 472759006768 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 472759006769 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 472759006770 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 472759006771 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 472759006772 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 472759006773 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 472759006774 Subunit I/III interface [polypeptide binding]; other site 472759006775 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 472759006776 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 472759006777 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 472759006778 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 472759006779 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 472759006780 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 472759006781 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 472759006782 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 472759006783 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 472759006784 PDZ domain; Region: PDZ_2; pfam13180 472759006785 protein binding site [polypeptide binding]; other site 472759006786 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 472759006787 Transcriptional regulators [Transcription]; Region: MarR; COG1846 472759006788 PemK-like protein; Region: PemK; pfam02452 472759006789 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 472759006790 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 472759006791 active site 472759006792 DNA gyrase subunit A; Validated; Region: PRK05560 472759006793 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 472759006794 CAP-like domain; other site 472759006795 active site 472759006796 primary dimer interface [polypeptide binding]; other site 472759006797 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 472759006798 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 472759006799 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 472759006800 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 472759006801 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 472759006802 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 472759006803 homodimer interface [polypeptide binding]; other site 472759006804 substrate-cofactor binding pocket; other site 472759006805 pyridoxal 5'-phosphate binding site [chemical binding]; other site 472759006806 catalytic residue [active] 472759006807 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 472759006808 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 472759006809 putative ligand binding site [chemical binding]; other site 472759006810 putative NAD binding site [chemical binding]; other site 472759006811 putative catalytic site [active] 472759006812 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 472759006813 L-serine binding site [chemical binding]; other site 472759006814 ACT domain interface; other site 472759006815 Chorismate mutase type II; Region: CM_2; cl00693 472759006816 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 472759006817 Prephenate dehydratase; Region: PDT; pfam00800 472759006818 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 472759006819 putative L-Phe binding site [chemical binding]; other site 472759006820 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 472759006821 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 472759006822 pyridoxal 5'-phosphate binding site [chemical binding]; other site 472759006823 homodimer interface [polypeptide binding]; other site 472759006824 catalytic residue [active] 472759006825 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 472759006826 prephenate dehydrogenase; Validated; Region: PRK08507 472759006827 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 472759006828 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 472759006829 hinge; other site 472759006830 active site 472759006831 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 472759006832 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 472759006833 motif II; other site 472759006834 cytidylate kinase; Provisional; Region: cmk; PRK00023 472759006835 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 472759006836 CMP-binding site; other site 472759006837 The sites determining sugar specificity; other site 472759006838 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 472759006839 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 472759006840 RNA binding site [nucleotide binding]; other site 472759006841 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 472759006842 RNA binding site [nucleotide binding]; other site 472759006843 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 472759006844 RNA binding site [nucleotide binding]; other site 472759006845 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 472759006846 RNA binding site [nucleotide binding]; other site 472759006847 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 472759006848 RNA binding site [nucleotide binding]; other site 472759006849 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 472759006850 RNA binding site [nucleotide binding]; other site 472759006851 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 472759006852 IHF dimer interface [polypeptide binding]; other site 472759006853 IHF - DNA interface [nucleotide binding]; other site 472759006854 Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560 472759006855 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 472759006856 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 472759006857 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 472759006858 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 472759006859 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 472759006860 DNA binding residues [nucleotide binding] 472759006861 Ferredoxin [Energy production and conversion]; Region: COG1146 472759006862 4Fe-4S binding domain; Region: Fer4; cl02805 472759006863 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 472759006864 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 472759006865 tetratricopeptide repeat protein; Provisional; Region: PRK11788 472759006866 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 472759006867 TPR motif; other site 472759006868 binding surface 472759006869 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 472759006870 binding surface 472759006871 TPR motif; other site 472759006872 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 472759006873 binding surface 472759006874 TPR motif; other site 472759006875 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 472759006876 ArsC family; Region: ArsC; pfam03960 472759006877 catalytic residues [active] 472759006878 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 472759006879 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 472759006880 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 472759006881 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 472759006882 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 472759006883 pantothenate kinase; Reviewed; Region: PRK13328 472759006884 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 472759006885 Domain of unknown function DUF20; Region: UPF0118; pfam01594 472759006886 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 472759006887 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 472759006888 active site residue [active] 472759006889 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 472759006890 active site residue [active] 472759006891 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 472759006892 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 472759006893 active site 472759006894 metal binding site [ion binding]; metal-binding site 472759006895 hexamer interface [polypeptide binding]; other site 472759006896 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_39; cd04699 472759006897 nudix motif; other site 472759006898 Protein of unknown function (DUF1244); Region: DUF1244; cl01385 472759006899 Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl17217 472759006900 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 472759006901 flagellar motor protein PomA; Reviewed; Region: PRK08990 472759006902 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 472759006903 flagellar motor protein MotB; Reviewed; Region: motB; PRK08944 472759006904 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 472759006905 ligand binding site [chemical binding]; other site 472759006906 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 472759006907 VPS10 domain; Region: VPS10; smart00602 472759006908 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 472759006909 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 472759006910 ferredoxin-NADP reductase; Provisional; Region: PRK10926 472759006911 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 472759006912 FAD binding pocket [chemical binding]; other site 472759006913 FAD binding motif [chemical binding]; other site 472759006914 phosphate binding motif [ion binding]; other site 472759006915 beta-alpha-beta structure motif; other site 472759006916 NAD binding pocket [chemical binding]; other site 472759006917 Domain of unknown function (DUF427); Region: DUF427; pfam04248 472759006918 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 472759006919 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 472759006920 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 472759006921 ABC-ATPase subunit interface; other site 472759006922 dimer interface [polypeptide binding]; other site 472759006923 putative PBP binding regions; other site 472759006924 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 472759006925 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 472759006926 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 472759006927 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 472759006928 cobalamin binding residues [chemical binding]; other site 472759006929 putative BtuC binding residues; other site 472759006930 dimer interface [polypeptide binding]; other site 472759006931 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 472759006932 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 472759006933 Cysteine-rich domain; Region: CCG; pfam02754 472759006934 Cysteine-rich domain; Region: CCG; pfam02754 472759006935 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 472759006936 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 472759006937 homodimer interface [polypeptide binding]; other site 472759006938 substrate-cofactor binding pocket; other site 472759006939 pyridoxal 5'-phosphate binding site [chemical binding]; other site 472759006940 catalytic residue [active] 472759006941 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 472759006942 putative inner membrane peptidase; Provisional; Region: PRK11778 472759006943 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 472759006944 tandem repeat interface [polypeptide binding]; other site 472759006945 oligomer interface [polypeptide binding]; other site 472759006946 active site residues [active] 472759006947 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 472759006948 FAD binding domain; Region: FAD_binding_4; pfam01565 472759006949 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 472759006950 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 472759006951 putative active site [active] 472759006952 putative PHP Thumb interface [polypeptide binding]; other site 472759006953 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 472759006954 generic binding surface II; other site 472759006955 generic binding surface I; other site 472759006956 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 472759006957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 472759006958 active site 472759006959 phosphorylation site [posttranslational modification] 472759006960 intermolecular recognition site; other site 472759006961 dimerization interface [polypeptide binding]; other site 472759006962 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 472759006963 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 472759006964 metal binding site [ion binding]; metal-binding site 472759006965 active site 472759006966 I-site; other site 472759006967 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 472759006968 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 472759006969 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 472759006970 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 472759006971 Ligand Binding Site [chemical binding]; other site 472759006972 TilS substrate binding domain; Region: TilS; pfam09179 472759006973 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 472759006974 CTP synthetase; Validated; Region: pyrG; PRK05380 472759006975 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 472759006976 Catalytic site [active] 472759006977 active site 472759006978 UTP binding site [chemical binding]; other site 472759006979 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 472759006980 active site 472759006981 putative oxyanion hole; other site 472759006982 catalytic triad [active] 472759006983 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 472759006984 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 472759006985 enolase; Provisional; Region: eno; PRK00077 472759006986 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 472759006987 dimer interface [polypeptide binding]; other site 472759006988 metal binding site [ion binding]; metal-binding site 472759006989 substrate binding pocket [chemical binding]; other site 472759006990 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 472759006991 Septum formation initiator; Region: DivIC; cl17659 472759006992 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 472759006993 substrate binding site; other site 472759006994 dimer interface; other site 472759006995 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 472759006996 homotrimer interaction site [polypeptide binding]; other site 472759006997 zinc binding site [ion binding]; other site 472759006998 CDP-binding sites; other site 472759006999 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 472759007000 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 472759007001 Permutation of conserved domain; other site 472759007002 active site 472759007003 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cd01291 472759007004 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 472759007005 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 472759007006 metal binding site [ion binding]; metal-binding site 472759007007 active site 472759007008 I-site; other site 472759007009 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 472759007010 siroheme synthase; Provisional; Region: cysG; PRK10637 472759007011 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 472759007012 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 472759007013 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 472759007014 active site 472759007015 SAM binding site [chemical binding]; other site 472759007016 homodimer interface [polypeptide binding]; other site 472759007017 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05742 472759007018 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 472759007019 dimerization interface [polypeptide binding]; other site 472759007020 active site 472759007021 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 472759007022 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 472759007023 amidase catalytic site [active] 472759007024 substrate binding site [chemical binding]; other site 472759007025 Zn binding residues [ion binding]; other site 472759007026 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 472759007027 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755 472759007028 Protein of unknown function (DUF3135); Region: DUF3135; pfam11333 472759007029 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 472759007030 RNA binding surface [nucleotide binding]; other site 472759007031 putative hydrolase; Provisional; Region: PRK10985 472759007032 acetyl-CoA synthetase; Provisional; Region: PRK00174 472759007033 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 472759007034 active site 472759007035 CoA binding site [chemical binding]; other site 472759007036 acyl-activating enzyme (AAE) consensus motif; other site 472759007037 AMP binding site [chemical binding]; other site 472759007038 acetate binding site [chemical binding]; other site 472759007039 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 472759007040 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 472759007041 dimer interface [polypeptide binding]; other site 472759007042 decamer (pentamer of dimers) interface [polypeptide binding]; other site 472759007043 catalytic triad [active] 472759007044 peroxidatic and resolving cysteines [active] 472759007045 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 472759007046 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 472759007047 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 472759007048 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 472759007049 motif II; other site 472759007050 hypothetical protein; Provisional; Region: PRK08960 472759007051 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 472759007052 pyridoxal 5'-phosphate binding site [chemical binding]; other site 472759007053 homodimer interface [polypeptide binding]; other site 472759007054 catalytic residue [active] 472759007055 Methyltransferase domain; Region: Methyltransf_23; pfam13489 472759007056 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759007057 S-adenosylmethionine binding site [chemical binding]; other site 472759007058 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 472759007059 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 472759007060 Walker A/P-loop; other site 472759007061 ATP binding site [chemical binding]; other site 472759007062 Q-loop/lid; other site 472759007063 ABC transporter signature motif; other site 472759007064 Walker B; other site 472759007065 D-loop; other site 472759007066 H-loop/switch region; other site 472759007067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 472759007068 dimer interface [polypeptide binding]; other site 472759007069 conserved gate region; other site 472759007070 putative PBP binding loops; other site 472759007071 ABC-ATPase subunit interface; other site 472759007072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 472759007073 dimer interface [polypeptide binding]; other site 472759007074 conserved gate region; other site 472759007075 putative PBP binding loops; other site 472759007076 ABC-ATPase subunit interface; other site 472759007077 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 472759007078 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 472759007079 substrate binding pocket [chemical binding]; other site 472759007080 membrane-bound complex binding site; other site 472759007081 hinge residues; other site 472759007082 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 472759007083 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 472759007084 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 472759007085 inhibitor-cofactor binding pocket; inhibition site 472759007086 pyridoxal 5'-phosphate binding site [chemical binding]; other site 472759007087 catalytic residue [active] 472759007088 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 472759007089 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 472759007090 Coenzyme A binding pocket [chemical binding]; other site 472759007091 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 472759007092 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 472759007093 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 472759007094 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 472759007095 Na binding site [ion binding]; other site 472759007096 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 472759007097 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 472759007098 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 472759007099 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 472759007100 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 472759007101 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 472759007102 Walker A/P-loop; other site 472759007103 ATP binding site [chemical binding]; other site 472759007104 Q-loop/lid; other site 472759007105 ABC transporter signature motif; other site 472759007106 Walker B; other site 472759007107 D-loop; other site 472759007108 H-loop/switch region; other site 472759007109 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 472759007110 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 472759007111 Walker A/P-loop; other site 472759007112 ATP binding site [chemical binding]; other site 472759007113 Q-loop/lid; other site 472759007114 ABC transporter signature motif; other site 472759007115 Walker B; other site 472759007116 D-loop; other site 472759007117 H-loop/switch region; other site 472759007118 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 472759007119 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 472759007120 HlyD family secretion protein; Region: HlyD_3; pfam13437 472759007121 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 472759007122 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 472759007123 dimer interface [polypeptide binding]; other site 472759007124 active site 472759007125 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 472759007126 hypothetical protein; Provisional; Region: PRK05409 472759007127 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 472759007128 Protein of unknown function (DUF422); Region: DUF422; cl00991 472759007129 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 472759007130 PemK-like protein; Region: PemK; pfam02452 472759007131 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 472759007132 M28 Zn-Peptidases; Region: M28_like_1; cd05640 472759007133 Peptidase family M28; Region: Peptidase_M28; pfam04389 472759007134 metal binding site [ion binding]; metal-binding site 472759007135 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 472759007136 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 472759007137 Probable transposase; Region: OrfB_IS605; pfam01385 472759007138 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 472759007139 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 472759007140 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 472759007141 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 472759007142 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 472759007143 active site 472759007144 TDP-binding site; other site 472759007145 acceptor substrate-binding pocket; other site 472759007146 homodimer interface [polypeptide binding]; other site 472759007147 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 472759007148 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 472759007149 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 472759007150 minor groove reading motif; other site 472759007151 helix-hairpin-helix signature motif; other site 472759007152 substrate binding pocket [chemical binding]; other site 472759007153 active site 472759007154 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 472759007155 electron transport complex RsxE subunit; Provisional; Region: PRK12405 472759007156 FMN-binding domain; Region: FMN_bind; cl01081 472759007157 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 472759007158 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 472759007159 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 472759007160 SLBB domain; Region: SLBB; pfam10531 472759007161 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 472759007162 ferredoxin; Provisional; Region: PRK08764 472759007163 Putative Fe-S cluster; Region: FeS; pfam04060 472759007164 4Fe-4S binding domain; Region: Fer4; pfam00037 472759007165 electron transport complex protein RsxA; Provisional; Region: PRK05151 472759007166 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 472759007167 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 472759007168 active site 472759007169 HIGH motif; other site 472759007170 KMSKS motif; other site 472759007171 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 472759007172 tRNA binding surface [nucleotide binding]; other site 472759007173 anticodon binding site; other site 472759007174 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 472759007175 dimer interface [polypeptide binding]; other site 472759007176 putative tRNA-binding site [nucleotide binding]; other site 472759007177 antiporter inner membrane protein; Provisional; Region: PRK11670 472759007178 Domain of unknown function DUF59; Region: DUF59; pfam01883 472759007179 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 472759007180 Walker A motif; other site 472759007181 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 472759007182 Transposase IS200 like; Region: Y1_Tnp; pfam01797 472759007183 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 472759007184 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 472759007185 Probable transposase; Region: OrfB_IS605; pfam01385 472759007186 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 472759007187 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 472759007188 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 472759007189 FOG: CBS domain [General function prediction only]; Region: COG0517 472759007190 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 472759007191 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 472759007192 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 472759007193 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 472759007194 FAD binding domain; Region: FAD_binding_4; pfam01565 472759007195 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 472759007196 active site 472759007197 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 472759007198 homodimer interface [polypeptide binding]; other site 472759007199 pyridoxal 5'-phosphate binding site [chemical binding]; other site 472759007200 catalytic residue [active] 472759007201 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_5; cd06153 472759007202 homotrimer interaction site [polypeptide binding]; other site 472759007203 putative active site [active] 472759007204 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 472759007205 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 472759007206 metal binding site [ion binding]; metal-binding site 472759007207 dimer interface [polypeptide binding]; other site 472759007208 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 472759007209 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 472759007210 trimer interface [polypeptide binding]; other site 472759007211 active site 472759007212 substrate binding site [chemical binding]; other site 472759007213 CoA binding site [chemical binding]; other site 472759007214 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 472759007215 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 472759007216 pyridoxal 5'-phosphate binding site [chemical binding]; other site 472759007217 homodimer interface [polypeptide binding]; other site 472759007218 catalytic residue [active] 472759007219 ribosome maturation protein RimP; Reviewed; Region: PRK00092 472759007220 Sm and related proteins; Region: Sm_like; cl00259 472759007221 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 472759007222 putative oligomer interface [polypeptide binding]; other site 472759007223 putative RNA binding site [nucleotide binding]; other site 472759007224 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 472759007225 NusA N-terminal domain; Region: NusA_N; pfam08529 472759007226 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 472759007227 RNA binding site [nucleotide binding]; other site 472759007228 homodimer interface [polypeptide binding]; other site 472759007229 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 472759007230 G-X-X-G motif; other site 472759007231 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 472759007232 G-X-X-G motif; other site 472759007233 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 472759007234 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 472759007235 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 472759007236 translation initiation factor IF-2; Region: IF-2; TIGR00487 472759007237 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 472759007238 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 472759007239 G1 box; other site 472759007240 putative GEF interaction site [polypeptide binding]; other site 472759007241 GTP/Mg2+ binding site [chemical binding]; other site 472759007242 Switch I region; other site 472759007243 G2 box; other site 472759007244 G3 box; other site 472759007245 Switch II region; other site 472759007246 G4 box; other site 472759007247 G5 box; other site 472759007248 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 472759007249 Translation-initiation factor 2; Region: IF-2; pfam11987 472759007250 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 472759007251 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 472759007252 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 472759007253 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 472759007254 RNA binding site [nucleotide binding]; other site 472759007255 active site 472759007256 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 472759007257 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 472759007258 16S/18S rRNA binding site [nucleotide binding]; other site 472759007259 S13e-L30e interaction site [polypeptide binding]; other site 472759007260 25S rRNA binding site [nucleotide binding]; other site 472759007261 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 472759007262 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 472759007263 RNase E interface [polypeptide binding]; other site 472759007264 trimer interface [polypeptide binding]; other site 472759007265 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 472759007266 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 472759007267 RNase E interface [polypeptide binding]; other site 472759007268 trimer interface [polypeptide binding]; other site 472759007269 active site 472759007270 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 472759007271 putative nucleic acid binding region [nucleotide binding]; other site 472759007272 G-X-X-G motif; other site 472759007273 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 472759007274 RNA binding site [nucleotide binding]; other site 472759007275 domain interface; other site 472759007276 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 472759007277 homodimer interface [polypeptide binding]; other site 472759007278 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 472759007279 active site pocket [active] 472759007280 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 472759007281 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 472759007282 active site 1 [active] 472759007283 dimer interface [polypeptide binding]; other site 472759007284 active site 2 [active] 472759007285 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 472759007286 dinuclear metal binding motif [ion binding]; other site 472759007287 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 472759007288 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 472759007289 tetramer interface [polypeptide binding]; other site 472759007290 TPP-binding site [chemical binding]; other site 472759007291 heterodimer interface [polypeptide binding]; other site 472759007292 phosphorylation loop region [posttranslational modification] 472759007293 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 472759007294 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 472759007295 alpha subunit interface [polypeptide binding]; other site 472759007296 TPP binding site [chemical binding]; other site 472759007297 heterodimer interface [polypeptide binding]; other site 472759007298 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 472759007299 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 472759007300 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 472759007301 E3 interaction surface; other site 472759007302 lipoyl attachment site [posttranslational modification]; other site 472759007303 e3 binding domain; Region: E3_binding; pfam02817 472759007304 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 472759007305 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 472759007306 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 472759007307 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 472759007308 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 472759007309 argininosuccinate synthase; Provisional; Region: PRK13820 472759007310 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 472759007311 ANP binding site [chemical binding]; other site 472759007312 Substrate Binding Site II [chemical binding]; other site 472759007313 Substrate Binding Site I [chemical binding]; other site 472759007314 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 472759007315 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 472759007316 adenylosuccinate lyase; Provisional; Region: PRK09285 472759007317 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 472759007318 tetramer interface [polypeptide binding]; other site 472759007319 active site 472759007320 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 472759007321 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 472759007322 substrate binding site [chemical binding]; other site 472759007323 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 472759007324 substrate binding site [chemical binding]; other site 472759007325 ligand binding site [chemical binding]; other site 472759007326 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 472759007327 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 472759007328 active site 472759007329 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 472759007330 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 472759007331 potential catalytic triad [active] 472759007332 conserved cys residue [active] 472759007333 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 472759007334 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 472759007335 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 472759007336 ligand binding site [chemical binding]; other site 472759007337 putative lysogenization regulator; Reviewed; Region: PRK00218 472759007338 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 472759007339 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 472759007340 putative GTP cyclohydrolase; Provisional; Region: PRK13674 472759007341 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 472759007342 active site 472759007343 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 472759007344 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 472759007345 substrate binding pocket [chemical binding]; other site 472759007346 chain length determination region; other site 472759007347 substrate-Mg2+ binding site; other site 472759007348 catalytic residues [active] 472759007349 aspartate-rich region 1; other site 472759007350 active site lid residues [active] 472759007351 aspartate-rich region 2; other site 472759007352 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 472759007353 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 472759007354 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 472759007355 active site 472759007356 Riboflavin kinase; Region: Flavokinase; smart00904 472759007357 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 472759007358 binding surface 472759007359 TPR motif; other site 472759007360 glycerate dehydrogenase; Provisional; Region: PRK06487 472759007361 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 472759007362 putative ligand binding site [chemical binding]; other site 472759007363 putative NAD binding site [chemical binding]; other site 472759007364 catalytic site [active] 472759007365 Domain of unknown function (DUF1820); Region: DUF1820; pfam08850 472759007366 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 472759007367 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 472759007368 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 472759007369 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 472759007370 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 472759007371 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 472759007372 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 472759007373 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 472759007374 dimer interface [polypeptide binding]; other site 472759007375 active site 472759007376 glycine-pyridoxal phosphate binding site [chemical binding]; other site 472759007377 folate binding site [chemical binding]; other site 472759007378 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 472759007379 ATP cone domain; Region: ATP-cone; pfam03477 472759007380 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 472759007381 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 472759007382 catalytic motif [active] 472759007383 Zn binding site [ion binding]; other site 472759007384 RibD C-terminal domain; Region: RibD_C; cl17279 472759007385 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 472759007386 Lumazine binding domain; Region: Lum_binding; pfam00677 472759007387 Lumazine binding domain; Region: Lum_binding; pfam00677 472759007388 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 472759007389 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 472759007390 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 472759007391 dimerization interface [polypeptide binding]; other site 472759007392 active site 472759007393 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 472759007394 RNA/DNA hybrid binding site [nucleotide binding]; other site 472759007395 active site 472759007396 Haemolysin-III related; Region: HlyIII; cl03831 472759007397 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 472759007398 Na+/H+ antiporter 1; Region: Na_H_antiport_1; pfam06965 472759007399 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 472759007400 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 472759007401 Probable transposase; Region: OrfB_IS605; pfam01385 472759007402 Transposase, Mutator family; Region: Transposase_mut; pfam00872 472759007403 MULE transposase domain; Region: MULE; pfam10551 472759007404 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 472759007405 putative active site [active] 472759007406 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 472759007407 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 472759007408 G1 box; other site 472759007409 putative GEF interaction site [polypeptide binding]; other site 472759007410 GTP/Mg2+ binding site [chemical binding]; other site 472759007411 Switch I region; other site 472759007412 G2 box; other site 472759007413 G3 box; other site 472759007414 Switch II region; other site 472759007415 G4 box; other site 472759007416 G5 box; other site 472759007417 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 472759007418 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 472759007419 active site 472759007420 catalytic residues [active] 472759007421 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 472759007422 active site 472759007423 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 472759007424 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 472759007425 Transposase, Mutator family; Region: Transposase_mut; pfam00872 472759007426 MULE transposase domain; Region: MULE; pfam10551 472759007427 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09741 472759007428 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 472759007429 CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578 472759007430 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622 472759007431 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 472759007432 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438 472759007433 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437 472759007434 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 472759007435 putative active site [active] 472759007436 CRISPR-associated protein (Cas_Cas02710); Region: Cas_Cas02710; pfam09670 472759007437 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817 472759007438 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 472759007439 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817 472759007440 Domain of unknown function (DUF1887); Region: DUF1887; pfam09002 472759007441 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl01634 472759007442 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 472759007443 Transposase [DNA replication, recombination, and repair]; Region: COG5421 472759007444 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 472759007445 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 472759007446 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 472759007447 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 472759007448 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 472759007449 active site 472759007450 catalytic site [active] 472759007451 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 472759007452 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 472759007453 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 472759007454 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 472759007455 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 472759007456 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 472759007457 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 472759007458 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 472759007459 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 472759007460 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 472759007461 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 472759007462 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 472759007463 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 472759007464 NAD(P) binding site [chemical binding]; other site 472759007465 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 472759007466 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 472759007467 putative active site [active] 472759007468 transaldolase; Provisional; Region: PRK03903 472759007469 catalytic residue [active] 472759007470 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 472759007471 MgtE intracellular N domain; Region: MgtE_N; smart00924 472759007472 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 472759007473 Divalent cation transporter; Region: MgtE; pfam01769 472759007474 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 472759007475 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 472759007476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 472759007477 dimer interface [polypeptide binding]; other site 472759007478 conserved gate region; other site 472759007479 putative PBP binding loops; other site 472759007480 ABC-ATPase subunit interface; other site 472759007481 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 472759007482 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 472759007483 dimer interface [polypeptide binding]; other site 472759007484 conserved gate region; other site 472759007485 putative PBP binding loops; other site 472759007486 ABC-ATPase subunit interface; other site 472759007487 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 472759007488 beta-hexosaminidase; Provisional; Region: PRK05337 472759007489 YcfA-like protein; Region: YcfA; pfam07927 472759007490 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 472759007491 Predicted transcriptional regulator [Transcription]; Region: COG3905 472759007492 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 472759007493 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 472759007494 nucleophile elbow; other site 472759007495 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 472759007496 active site 472759007497 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 472759007498 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 472759007499 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 472759007500 catalytic residues [active] 472759007501 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 472759007502 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 472759007503 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 472759007504 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 472759007505 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 472759007506 Zn binding site [ion binding]; other site 472759007507 M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663 472759007508 Peptidase family M28; Region: Peptidase_M28; pfam04389 472759007509 metal binding site [ion binding]; metal-binding site 472759007510 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 472759007511 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 472759007512 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 472759007513 Walker A/P-loop; other site 472759007514 ATP binding site [chemical binding]; other site 472759007515 Q-loop/lid; other site 472759007516 ABC transporter signature motif; other site 472759007517 Walker B; other site 472759007518 D-loop; other site 472759007519 H-loop/switch region; other site 472759007520 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 472759007521 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 472759007522 FtsX-like permease family; Region: FtsX; pfam02687 472759007523 HlyD family secretion protein; Region: HlyD_3; pfam13437 472759007524 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 472759007525 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 472759007526 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 472759007527 Uncharacterized conserved protein [Function unknown]; Region: COG3391 472759007528 Transposase IS200 like; Region: Y1_Tnp; pfam01797 472759007529 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 472759007530 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 472759007531 Probable transposase; Region: OrfB_IS605; pfam01385 472759007532 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 472759007533 Tetratricopeptide repeat; Region: TPR_12; pfam13424 472759007534 Domain of unknown function DUF59; Region: DUF59; cl00941 472759007535 NnrS protein; Region: NnrS; pfam05940 472759007536 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 472759007537 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 472759007538 substrate binding pocket [chemical binding]; other site 472759007539 membrane-bound complex binding site; other site 472759007540 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 472759007541 PAS fold; Region: PAS_3; pfam08447 472759007542 putative active site [active] 472759007543 heme pocket [chemical binding]; other site 472759007544 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 472759007545 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 472759007546 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 472759007547 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 472759007548 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 472759007549 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 472759007550 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 472759007551 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 472759007552 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 472759007553 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 472759007554 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 472759007555 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 472759007556 Protein of unknown function (DUF938); Region: DUF938; pfam06080 472759007557 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 472759007558 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 472759007559 homodimer interface [polypeptide binding]; other site 472759007560 active site 472759007561 TDP-binding site; other site 472759007562 acceptor substrate-binding pocket; other site 472759007563 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 472759007564 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 472759007565 dimer interface [polypeptide binding]; other site 472759007566 TPP-binding site [chemical binding]; other site 472759007567 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 472759007568 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 472759007569 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 472759007570 E3 interaction surface; other site 472759007571 lipoyl attachment site [posttranslational modification]; other site 472759007572 e3 binding domain; Region: E3_binding; pfam02817 472759007573 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 472759007574 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 472759007575 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 472759007576 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 472759007577 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 472759007578 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 472759007579 active site 472759007580 universal stress protein UspE; Provisional; Region: PRK11175 472759007581 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 472759007582 Ligand Binding Site [chemical binding]; other site 472759007583 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 472759007584 Ligand Binding Site [chemical binding]; other site 472759007585 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 472759007586 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 472759007587 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 472759007588 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 472759007589 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 472759007590 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 472759007591 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 472759007592 putative active site [active] 472759007593 putative metal binding site [ion binding]; other site 472759007594 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 472759007595 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 472759007596 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 472759007597 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 472759007598 active site residue [active] 472759007599 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 472759007600 nucleophilic elbow; other site 472759007601 catalytic triad; other site 472759007602 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 472759007603 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 472759007604 Ligand Binding Site [chemical binding]; other site 472759007605 Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934 472759007606 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 472759007607 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 472759007608 methionine sulfoxide reductase A; Provisional; Region: PRK00058 472759007609 Protein of unknown function (DUF423); Region: DUF423; pfam04241 472759007610 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 472759007611 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 472759007612 Predicted membrane protein [Function unknown]; Region: COG3503 472759007613 WYL domain; Region: WYL; pfam13280 472759007614 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 472759007615 CRISPR/Cas system-associated protein Cas10d; Region: Cas10d_I-D; cd09712 472759007616 CRISPR/Cas system-associated protein Csc2; Region: Csc2_I-D; cl11869 472759007617 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 472759007618 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 472759007619 ATP binding site [chemical binding]; other site 472759007620 putative Mg++ binding site [ion binding]; other site 472759007621 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 472759007622 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 472759007623 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 472759007624 Protein of unknown function (DUF2396); Region: DUF2396; cl09868 472759007625 DDE superfamily endonuclease; Region: DDE_3; pfam13358 472759007626 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 472759007627 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 472759007628 Helix-turn-helix domain; Region: HTH_28; pfam13518 472759007629 Homeodomain-like domain; Region: HTH_32; pfam13565 472759007630 Predicted transcriptional regulator [Transcription]; Region: COG4190 472759007631 Helix-turn-helix domain; Region: HTH_20; pfam12840 472759007632 antitoxin MqsA for MqsR toxin; Region: MqsA; cl15819 472759007633 Zn binding site [ion binding]; other site 472759007634 toxin interface [polypeptide binding]; other site 472759007635 Transposase IS200 like; Region: Y1_Tnp; pfam01797 472759007636 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 472759007637 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 472759007638 Probable transposase; Region: OrfB_IS605; pfam01385 472759007639 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 472759007640 BCCT family transporter; Region: BCCT; pfam02028 472759007641 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 472759007642 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 472759007643 Protein of unknown function (DUF3047); Region: DUF3047; pfam11249 472759007644 Uncharacterized conserved protein [Function unknown]; Region: COG0398 472759007645 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 472759007646 mercuric reductase; Validated; Region: PRK06370 472759007647 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 472759007648 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 472759007649 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 472759007650 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 472759007651 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 472759007652 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 472759007653 Transposase, Mutator family; Region: Transposase_mut; pfam00872 472759007654 MULE transposase domain; Region: MULE; pfam10551 472759007655 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 472759007656 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 472759007657 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 472759007658 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 472759007659 Protein of unknown function (DUF3179); Region: DUF3179; pfam11376 472759007660 Putative zinc-finger; Region: zf-HC2; pfam13490 472759007661 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 472759007662 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 472759007663 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 472759007664 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 472759007665 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 472759007666 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 472759007667 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 472759007668 hypothetical protein; Reviewed; Region: PRK09588 472759007669 Protein of unknown function DUF72; Region: DUF72; pfam01904 472759007670 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 472759007671 nucleotide binding site [chemical binding]; other site 472759007672 putative NEF/HSP70 interaction site [polypeptide binding]; other site 472759007673 SBD interface [polypeptide binding]; other site 472759007674 DNA-K related protein; Region: DUF3731; pfam12531 472759007675 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 472759007676 nucleotide binding site [chemical binding]; other site 472759007677 putative NEF/HSP70 interaction site [polypeptide binding]; other site 472759007678 SBD interface [polypeptide binding]; other site 472759007679 Domain of unknown function (DUF2760); Region: DUF2760; pfam10816 472759007680 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 472759007681 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 472759007682 Class I aldolases; Region: Aldolase_Class_I; cl17187 472759007683 transaldolase; Provisional; Region: PRK03903 472759007684 catalytic residue [active] 472759007685 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 472759007686 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 472759007687 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 472759007688 active site 472759007689 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 472759007690 N-acetyl-D-glucosamine binding site [chemical binding]; other site 472759007691 catalytic residue [active] 472759007692 methionine sulfoxide reductase B; Provisional; Region: PRK00222 472759007693 SelR domain; Region: SelR; pfam01641 472759007694 UV radiation resistance protein and autophagy-related subunit 14; Region: Atg14; pfam10186 472759007695 AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061 472759007696 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309 472759007697 dimerization interface [polypeptide binding]; other site 472759007698 putative ATP binding site [chemical binding]; other site 472759007699 probable DNA repair protein; Region: TIGR03623 472759007700 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 472759007701 Part of AAA domain; Region: AAA_19; pfam13245 472759007702 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 472759007703 Family description; Region: UvrD_C_2; pfam13538 472759007704 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 472759007705 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 472759007706 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 472759007707 putative catalytic residue [active] 472759007708 pyruvate kinase; Provisional; Region: PRK05826 472759007709 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 472759007710 domain interfaces; other site 472759007711 active site 472759007712 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 472759007713 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 472759007714 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 472759007715 tocopherol O-methyltransferase; Region: PLN02244 472759007716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759007717 S-adenosylmethionine binding site [chemical binding]; other site 472759007718 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 472759007719 AAA domain; Region: AAA_30; pfam13604 472759007720 Family description; Region: UvrD_C_2; pfam13538 472759007721 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 472759007722 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 472759007723 Walker A/P-loop; other site 472759007724 ATP binding site [chemical binding]; other site 472759007725 Q-loop/lid; other site 472759007726 ABC transporter signature motif; other site 472759007727 Walker B; other site 472759007728 D-loop; other site 472759007729 H-loop/switch region; other site 472759007730 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 472759007731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 472759007732 dimer interface [polypeptide binding]; other site 472759007733 conserved gate region; other site 472759007734 putative PBP binding loops; other site 472759007735 ABC-ATPase subunit interface; other site 472759007736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 472759007737 dimer interface [polypeptide binding]; other site 472759007738 conserved gate region; other site 472759007739 putative PBP binding loops; other site 472759007740 ABC-ATPase subunit interface; other site 472759007741 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 472759007742 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 472759007743 dimerization interface [polypeptide binding]; other site 472759007744 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 472759007745 dimerization interface [polypeptide binding]; other site 472759007746 putative DNA binding site [nucleotide binding]; other site 472759007747 putative Zn2+ binding site [ion binding]; other site 472759007748 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 472759007749 putative catalytic site [active] 472759007750 putative metal binding site [ion binding]; other site 472759007751 putative phosphate binding site [ion binding]; other site 472759007752 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 472759007753 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 472759007754 putative NADP binding site [chemical binding]; other site 472759007755 putative substrate binding site [chemical binding]; other site 472759007756 active site 472759007757 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 472759007758 tellurite resistance protein terB; Region: terB; cd07176 472759007759 putative metal binding site [ion binding]; other site 472759007760 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 472759007761 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 472759007762 putative metal binding site [ion binding]; other site 472759007763 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 472759007764 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 472759007765 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 472759007766 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 472759007767 hypothetical protein; Provisional; Region: PRK14013 472759007768 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 472759007769 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 472759007770 putative metal binding site [ion binding]; other site 472759007771 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 472759007772 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 472759007773 active site 472759007774 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 472759007775 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 472759007776 RES domain; Region: RES; smart00953 472759007777 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 472759007778 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 472759007779 catalytic residues [active] 472759007780 catalytic nucleophile [active] 472759007781 Recombinase; Region: Recombinase; pfam07508 472759007782 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 472759007783 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 472759007784 conserved cys residue [active] 472759007785 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 472759007786 Putative molybdenum carrier; Region: MoCo_carrier; pfam12694 472759007787 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 472759007788 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 472759007789 multifunctional aminopeptidase A; Provisional; Region: PRK00913 472759007790 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 472759007791 interface (dimer of trimers) [polypeptide binding]; other site 472759007792 Substrate-binding/catalytic site; other site 472759007793 Zn-binding sites [ion binding]; other site 472759007794 Short C-terminal domain; Region: SHOCT; pfam09851 472759007795 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 472759007796 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 472759007797 active site 472759007798 ATP binding site [chemical binding]; other site 472759007799 substrate binding site [chemical binding]; other site 472759007800 activation loop (A-loop); other site 472759007801 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 472759007802 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 472759007803 Uncharacterized conserved protein [Function unknown]; Region: COG1262 472759007804 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 472759007805 Uncharacterized conserved protein [Function unknown]; Region: COG2442 472759007806 TIR domain; Region: TIR_2; pfam13676 472759007807 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 472759007808 phosphopeptide binding site; other site 472759007809 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 472759007810 phosphopeptide binding site; other site 472759007811 Predicted permeases [General function prediction only]; Region: COG0795 472759007812 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 472759007813 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 472759007814 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 472759007815 RDD family; Region: RDD; pfam06271 472759007816 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 472759007817 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 472759007818 dimerization interface [polypeptide binding]; other site 472759007819 ATP binding site [chemical binding]; other site 472759007820 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 472759007821 dimerization interface [polypeptide binding]; other site 472759007822 ATP binding site [chemical binding]; other site 472759007823 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 472759007824 putative active site [active] 472759007825 catalytic triad [active] 472759007826 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 472759007827 Smr domain; Region: Smr; pfam01713 472759007828 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 472759007829 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 472759007830 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 472759007831 Protein of unknown function (DUF497); Region: DUF497; pfam04365 472759007832 Domain of unknown function DUF29; Region: DUF29; pfam01724 472759007833 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 472759007834 Domain of unknown function DUF29; Region: DUF29; pfam01724 472759007835 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 472759007836 HicB family; Region: HicB; pfam05534 472759007837 ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351 472759007838 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 472759007839 metal binding site [ion binding]; metal-binding site 472759007840 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 472759007841 nucleotide binding site [chemical binding]; other site 472759007842 Domain of unknown function (DUF3330); Region: DUF3330; pfam11809 472759007843 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 472759007844 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 472759007845 TspO/MBR family; Region: TspO_MBR; pfam03073 472759007846 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 472759007847 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 472759007848 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 472759007849 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 472759007850 D-pathway; other site 472759007851 Putative ubiquinol binding site [chemical binding]; other site 472759007852 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 472759007853 Low-spin heme (heme b) binding site [chemical binding]; other site 472759007854 Putative water exit pathway; other site 472759007855 Binuclear center (heme o3/CuB) [ion binding]; other site 472759007856 K-pathway; other site 472759007857 Putative proton exit pathway; other site 472759007858 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 472759007859 Subunit I/III interface [polypeptide binding]; other site 472759007860 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 472759007861 Cytochrome c; Region: Cytochrom_C; cl11414 472759007862 Cytochrome c; Region: Cytochrom_C; cl11414 472759007863 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 472759007864 ATP binding site [chemical binding]; other site 472759007865 Mg2+ binding site [ion binding]; other site 472759007866 G-X-G motif; other site 472759007867 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 472759007868 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 472759007869 active site 472759007870 phosphorylation site [posttranslational modification] 472759007871 intermolecular recognition site; other site 472759007872 dimerization interface [polypeptide binding]; other site 472759007873 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 472759007874 DNA binding site [nucleotide binding] 472759007875 Predicted membrane protein [Function unknown]; Region: COG3212 472759007876 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 472759007877 Predicted membrane protein [Function unknown]; Region: COG3212 472759007878 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 472759007879 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 472759007880 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 472759007881 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 472759007882 putative active site [active] 472759007883 Glucokinase; Region: Glucokinase; pfam02685 472759007884 glucokinase, proteobacterial type; Region: glk; TIGR00749 472759007885 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 472759007886 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 472759007887 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 472759007888 active site 472759007889 metal binding site [ion binding]; metal-binding site 472759007890 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 472759007891 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 472759007892 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 472759007893 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 472759007894 NAD(P) binding site [chemical binding]; other site 472759007895 active site 472759007896 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 472759007897 active site clefts [active] 472759007898 zinc binding site [ion binding]; other site 472759007899 dimer interface [polypeptide binding]; other site 472759007900 Protein of unknown function (DUF938); Region: DUF938; pfam06080 472759007901 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 472759007902 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759007903 Walker A motif; other site 472759007904 ATP binding site [chemical binding]; other site 472759007905 Walker B motif; other site 472759007906 arginine finger; other site 472759007907 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 472759007908 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 472759007909 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 472759007910 active site 472759007911 substrate binding site [chemical binding]; other site 472759007912 Mg2+ binding site [ion binding]; other site 472759007913 probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684 472759007914 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 472759007915 Protein of unknown function (DUF1326); Region: DUF1326; pfam07040 472759007916 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 472759007917 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 472759007918 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 472759007919 Peptidase family M48; Region: Peptidase_M48; cl12018 472759007920 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 472759007921 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 472759007922 putative ADP-ribose binding site [chemical binding]; other site 472759007923 putative active site [active] 472759007924 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 472759007925 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 472759007926 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 472759007927 active site 472759007928 DNA binding site [nucleotide binding] 472759007929 Int/Topo IB signature motif; other site 472759007930 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 472759007931 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759007932 Walker A motif; other site 472759007933 ATP binding site [chemical binding]; other site 472759007934 Walker B motif; other site 472759007935 Cupin domain; Region: Cupin_2; cl17218 472759007936 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 472759007937 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 472759007938 metal binding site [ion binding]; metal-binding site 472759007939 active site 472759007940 I-site; other site 472759007941 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 472759007942 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 472759007943 acyl-activating enzyme (AAE) consensus motif; other site 472759007944 putative AMP binding site [chemical binding]; other site 472759007945 putative active site [active] 472759007946 putative CoA binding site [chemical binding]; other site 472759007947 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 472759007948 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 472759007949 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 472759007950 putative acyl-acceptor binding pocket; other site 472759007951 Predicted flavoprotein [General function prediction only]; Region: COG0431 472759007952 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 472759007953 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 472759007954 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 472759007955 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 472759007956 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 472759007957 putative active site [active] 472759007958 putative metal binding site [ion binding]; other site 472759007959 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 472759007960 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 472759007961 GIY-YIG motif/motif A; other site 472759007962 active site 472759007963 catalytic site [active] 472759007964 putative DNA binding site [nucleotide binding]; other site 472759007965 metal binding site [ion binding]; metal-binding site 472759007966 UvrB/uvrC motif; Region: UVR; pfam02151 472759007967 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 472759007968 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 472759007969 Predicted membrane protein [Function unknown]; Region: COG1297 472759007970 putative oligopeptide transporter, OPT family; Region: TIGR00733 472759007971 dsRNA-gated channel SID-1; Region: SID-1_RNA_chan; pfam13965 472759007972 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 472759007973 propionate/acetate kinase; Provisional; Region: PRK12379 472759007974 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 472759007975 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 472759007976 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 472759007977 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 472759007978 active site 472759007979 catalytic site [active] 472759007980 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 472759007981 putative homodimer interface [polypeptide binding]; other site 472759007982 putative active site pocket [active] 472759007983 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 472759007984 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 472759007985 amino acid transporter; Region: 2A0306; TIGR00909 472759007986 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 472759007987 Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose; Region: GT1_Trehalose_phosphorylase; cd03792 472759007988 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 472759007989 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 472759007990 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 472759007991 catalytic site [active] 472759007992 active site 472759007993 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 472759007994 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 472759007995 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 472759007996 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 472759007997 active site 472759007998 catalytic site [active] 472759007999 trigger factor; Provisional; Region: tig; PRK01490 472759008000 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 472759008001 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 472759008002 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 472759008003 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 472759008004 oligomer interface [polypeptide binding]; other site 472759008005 active site residues [active] 472759008006 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 472759008007 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 472759008008 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759008009 Walker A motif; other site 472759008010 ATP binding site [chemical binding]; other site 472759008011 Walker B motif; other site 472759008012 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 472759008013 Found in ATP-dependent protease La (LON); Region: LON; smart00464 472759008014 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 472759008015 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759008016 Walker A motif; other site 472759008017 ATP binding site [chemical binding]; other site 472759008018 Walker B motif; other site 472759008019 arginine finger; other site 472759008020 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 472759008021 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 472759008022 Sporulation related domain; Region: SPOR; pfam05036 472759008023 Colicin V production protein; Region: Colicin_V; cl00567 472759008024 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 472759008025 amidophosphoribosyltransferase; Provisional; Region: PRK09246 472759008026 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 472759008027 tetramer interface [polypeptide binding]; other site 472759008028 active site 472759008029 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 472759008030 active site 472759008031 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 472759008032 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 472759008033 putative phosphate acyltransferase; Provisional; Region: PRK05331 472759008034 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 472759008035 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 472759008036 dimer interface [polypeptide binding]; other site 472759008037 active site 472759008038 CoA binding pocket [chemical binding]; other site 472759008039 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 472759008040 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 472759008041 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 472759008042 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 472759008043 NAD(P) binding site [chemical binding]; other site 472759008044 homotetramer interface [polypeptide binding]; other site 472759008045 homodimer interface [polypeptide binding]; other site 472759008046 active site 472759008047 acyl carrier protein; Provisional; Region: acpP; PRK00982 472759008048 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 472759008049 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 472759008050 dimer interface [polypeptide binding]; other site 472759008051 active site 472759008052 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 472759008053 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 472759008054 pyridoxal 5'-phosphate binding site [chemical binding]; other site 472759008055 catalytic residue [active] 472759008056 YceG-like family; Region: YceG; pfam02618 472759008057 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 472759008058 dimerization interface [polypeptide binding]; other site 472759008059 thymidylate kinase; Validated; Region: tmk; PRK00698 472759008060 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 472759008061 TMP-binding site; other site 472759008062 ATP-binding site [chemical binding]; other site 472759008063 DNA polymerase III subunit delta'; Validated; Region: PRK05707 472759008064 DNA polymerase III subunit delta'; Validated; Region: PRK08485 472759008065 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 472759008066 PilZ domain; Region: PilZ; cl01260 472759008067 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 472759008068 active site 472759008069 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 472759008070 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 472759008071 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 472759008072 catalytic residue [active] 472759008073 Domain of unknown function DUF29; Region: DUF29; pfam01724 472759008074 DNA replication terminus site-binding protein (Ter protein); Region: Ter; cl11502 472759008075 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 472759008076 putative active site pocket [active] 472759008077 dimerization interface [polypeptide binding]; other site 472759008078 putative catalytic residue [active] 472759008079 fumarate hydratase; Reviewed; Region: fumC; PRK00485 472759008080 Class II fumarases; Region: Fumarase_classII; cd01362 472759008081 active site 472759008082 tetramer interface [polypeptide binding]; other site 472759008083 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 472759008084 Sulfate transporter family; Region: Sulfate_transp; pfam00916 472759008085 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 472759008086 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 472759008087 HAMP domain; Region: HAMP; pfam00672 472759008088 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 472759008089 dimer interface [polypeptide binding]; other site 472759008090 phosphorylation site [posttranslational modification] 472759008091 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 472759008092 ATP binding site [chemical binding]; other site 472759008093 G-X-G motif; other site 472759008094 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 472759008095 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 472759008096 active site 472759008097 phosphorylation site [posttranslational modification] 472759008098 intermolecular recognition site; other site 472759008099 dimerization interface [polypeptide binding]; other site 472759008100 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759008101 Walker A motif; other site 472759008102 ATP binding site [chemical binding]; other site 472759008103 Walker B motif; other site 472759008104 arginine finger; other site 472759008105 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 472759008106 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 472759008107 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 472759008108 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 472759008109 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 472759008110 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 472759008111 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 472759008112 Cu(I) binding site [ion binding]; other site 472759008113 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 472759008114 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 472759008115 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 472759008116 ATP binding site [chemical binding]; other site 472759008117 putative Mg++ binding site [ion binding]; other site 472759008118 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 472759008119 nucleotide binding region [chemical binding]; other site 472759008120 ATP-binding site [chemical binding]; other site 472759008121 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 472759008122 Uncharacterized family 4; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_4; cd10161 472759008123 putative homodimer interface [polypeptide binding]; other site 472759008124 putative homotetramer interface [polypeptide binding]; other site 472759008125 putative metal binding site [ion binding]; other site 472759008126 putative homodimer-homodimer interface [polypeptide binding]; other site 472759008127 Predicted transporter component [General function prediction only]; Region: COG2391 472759008128 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 472759008129 Predicted transporter component [General function prediction only]; Region: COG2391 472759008130 Sulphur transport; Region: Sulf_transp; pfam04143 472759008131 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 472759008132 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 472759008133 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 472759008134 HSP70 interaction site [polypeptide binding]; other site 472759008135 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 472759008136 substrate binding site [polypeptide binding]; other site 472759008137 dimer interface [polypeptide binding]; other site 472759008138 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 472759008139 TrkA-N domain; Region: TrkA_N; pfam02254 472759008140 TrkA-C domain; Region: TrkA_C; pfam02080 472759008141 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 472759008142 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 472759008143 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 472759008144 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 472759008145 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 472759008146 ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214 472759008147 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 472759008148 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 472759008149 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 472759008150 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 472759008151 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 472759008152 dimer interface [polypeptide binding]; other site 472759008153 active site residues [active] 472759008154 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 472759008155 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 472759008156 thiS-thiF/thiG interaction site; other site 472759008157 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 472759008158 ThiS interaction site; other site 472759008159 putative active site [active] 472759008160 tetramer interface [polypeptide binding]; other site 472759008161 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 472759008162 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 472759008163 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759008164 Walker B motif; other site 472759008165 arginine finger; other site 472759008166 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 472759008167 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 472759008168 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 472759008169 GAF domain; Region: GAF; pfam01590 472759008170 GAF domain; Region: GAF_2; pfam13185 472759008171 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 472759008172 PAS domain; Region: PAS_9; pfam13426 472759008173 putative active site [active] 472759008174 heme pocket [chemical binding]; other site 472759008175 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 472759008176 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 472759008177 metal binding site [ion binding]; metal-binding site 472759008178 active site 472759008179 I-site; other site 472759008180 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 472759008181 glutathione reductase; Validated; Region: PRK06116 472759008182 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 472759008183 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 472759008184 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 472759008185 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 472759008186 anti sigma factor interaction site; other site 472759008187 regulatory phosphorylation site [posttranslational modification]; other site 472759008188 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 472759008189 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 472759008190 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 472759008191 substrate binding site [chemical binding]; other site 472759008192 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 472759008193 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 472759008194 active site 472759008195 dimer interface [polypeptide binding]; other site 472759008196 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 472759008197 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 472759008198 active site 472759008199 FMN binding site [chemical binding]; other site 472759008200 substrate binding site [chemical binding]; other site 472759008201 3Fe-4S cluster binding site [ion binding]; other site 472759008202 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 472759008203 domain interface; other site 472759008204 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 472759008205 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 472759008206 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 472759008207 anti sigma factor interaction site; other site 472759008208 regulatory phosphorylation site [posttranslational modification]; other site 472759008209 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 472759008210 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 472759008211 active site 472759008212 catalytic tetrad [active] 472759008213 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 472759008214 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 472759008215 motif II; other site 472759008216 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 472759008217 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 472759008218 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 472759008219 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 472759008220 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 472759008221 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 472759008222 aspartate aminotransferase; Provisional; Region: PRK05764 472759008223 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 472759008224 pyridoxal 5'-phosphate binding site [chemical binding]; other site 472759008225 homodimer interface [polypeptide binding]; other site 472759008226 catalytic residue [active] 472759008227 methionine sulfoxide reductase A; Provisional; Region: PRK14054 472759008228 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 472759008229 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 472759008230 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 472759008231 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 472759008232 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 472759008233 catalytic motif [active] 472759008234 Catalytic residue [active] 472759008235 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 472759008236 active site 472759008237 catalytic triad [active] 472759008238 oxyanion hole [active] 472759008239 switch loop; other site 472759008240 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 472759008241 sulfite oxidase; Provisional; Region: PLN00177 472759008242 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 472759008243 Moco binding site; other site 472759008244 metal coordination site [ion binding]; other site 472759008245 dimerization interface [polypeptide binding]; other site 472759008246 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 472759008247 quinohemoprotein amine dehydrogenase, alpha subunit; Region: QH_alpha; TIGR03908 472759008248 Uncharacterized conserved protein [Function unknown]; Region: COG0432 472759008249 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 472759008250 PUA domain; Region: PUA; cl00607 472759008251 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 472759008252 putative RNA binding site [nucleotide binding]; other site 472759008253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759008254 S-adenosylmethionine binding site [chemical binding]; other site 472759008255 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 472759008256 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 472759008257 homodimer interface [polypeptide binding]; other site 472759008258 substrate-cofactor binding pocket; other site 472759008259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 472759008260 catalytic residue [active] 472759008261 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 472759008262 PBP superfamily domain; Region: PBP_like_2; pfam12849 472759008263 N-acyl amino acid synthase, PEP-CTERM/exosortase system-associated; Region: exosort_acyl; TIGR03694 472759008264 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 472759008265 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 472759008266 DNA binding residues [nucleotide binding] 472759008267 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 472759008268 IHF dimer interface [polypeptide binding]; other site 472759008269 IHF - DNA interface [nucleotide binding]; other site 472759008270 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 472759008271 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 472759008272 putative tRNA-binding site [nucleotide binding]; other site 472759008273 B3/4 domain; Region: B3_4; pfam03483 472759008274 tRNA synthetase B5 domain; Region: B5; smart00874 472759008275 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 472759008276 dimer interface [polypeptide binding]; other site 472759008277 motif 1; other site 472759008278 motif 3; other site 472759008279 motif 2; other site 472759008280 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 472759008281 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 472759008282 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 472759008283 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 472759008284 dimer interface [polypeptide binding]; other site 472759008285 motif 1; other site 472759008286 active site 472759008287 motif 2; other site 472759008288 motif 3; other site 472759008289 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 472759008290 23S rRNA binding site [nucleotide binding]; other site 472759008291 L21 binding site [polypeptide binding]; other site 472759008292 L13 binding site [polypeptide binding]; other site 472759008293 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 472759008294 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 472759008295 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 472759008296 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 472759008297 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 472759008298 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 472759008299 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 472759008300 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 472759008301 active site 472759008302 dimer interface [polypeptide binding]; other site 472759008303 motif 1; other site 472759008304 motif 2; other site 472759008305 motif 3; other site 472759008306 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 472759008307 anticodon binding site; other site 472759008308 excinuclease ABC subunit B; Provisional; Region: PRK05298 472759008309 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 472759008310 ATP binding site [chemical binding]; other site 472759008311 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 472759008312 nucleotide binding region [chemical binding]; other site 472759008313 ATP-binding site [chemical binding]; other site 472759008314 Ultra-violet resistance protein B; Region: UvrB; pfam12344 472759008315 UvrB/uvrC motif; Region: UVR; pfam02151 472759008316 aspartate aminotransferase; Provisional; Region: PRK05764 472759008317 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 472759008318 pyridoxal 5'-phosphate binding site [chemical binding]; other site 472759008319 homodimer interface [polypeptide binding]; other site 472759008320 catalytic residue [active] 472759008321 Domain of unknown function DUF29; Region: DUF29; pfam01724 472759008322 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 472759008323 exosortase A system-associated hydrolase 2; Region: hydr2_PEP; TIGR03101 472759008324 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 472759008325 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 472759008326 Coenzyme A binding pocket [chemical binding]; other site 472759008327 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 472759008328 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 472759008329 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 472759008330 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 472759008331 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u9; cd10933 472759008332 putative active site [active] 472759008333 putative catalytic site [active] 472759008334 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 472759008335 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 472759008336 Ligand Binding Site [chemical binding]; other site 472759008337 Molecular Tunnel; other site 472759008338 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 472759008339 binding surface 472759008340 TPR motif; other site 472759008341 FkbH-like domain; Region: FkbH; TIGR01686 472759008342 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 472759008343 active site 472759008344 motif I; other site 472759008345 motif II; other site 472759008346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 472759008347 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 472759008348 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 472759008349 putative active site [active] 472759008350 putative metal binding site [ion binding]; other site 472759008351 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 472759008352 Trm112p-like protein; Region: Trm112p; cl01066 472759008353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759008354 S-adenosylmethionine binding site [chemical binding]; other site 472759008355 Phosphotransferase enzyme family; Region: APH; pfam01636 472759008356 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 472759008357 active site 472759008358 ATP binding site [chemical binding]; other site 472759008359 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 472759008360 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 472759008361 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 472759008362 acyl-activating enzyme (AAE) consensus motif; other site 472759008363 AMP binding site [chemical binding]; other site 472759008364 active site 472759008365 CoA binding site [chemical binding]; other site 472759008366 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 472759008367 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 472759008368 PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063 472759008369 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 472759008370 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 472759008371 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 472759008372 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 472759008373 active site 472759008374 dimer interface [polypeptide binding]; other site 472759008375 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 472759008376 Ligand Binding Site [chemical binding]; other site 472759008377 Molecular Tunnel; other site 472759008378 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 472759008379 active site 472759008380 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 472759008381 homodimer interface [polypeptide binding]; other site 472759008382 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 472759008383 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 472759008384 putative ADP-binding pocket [chemical binding]; other site 472759008385 exosortase A; Region: exosortase_1; TIGR03109 472759008386 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 472759008387 EpsI family protein; Region: EpsI_fam; TIGR02914 472759008388 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 472759008389 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 472759008390 FemAB-related protein, PEP-CTERM system-associated; Region: pepcterm_femAB; TIGR03019 472759008391 polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006 472759008392 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941 472759008393 putative active site [active] 472759008394 putative catalytic site [active] 472759008395 uncharacterized protein, PEP-CTERM system associated; Region: pepcterm_hypo_1; TIGR03016 472759008396 uncharacterized protein, PEP-CTERM system associated; Region: pepcterm_hypo_1; TIGR03016 472759008397 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 472759008398 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 472759008399 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 472759008400 Chain length determinant protein; Region: Wzz; pfam02706 472759008401 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 472759008402 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 472759008403 SLBB domain; Region: SLBB; pfam10531 472759008404 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 472759008405 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 472759008406 binding surface 472759008407 TPR motif; other site 472759008408 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 472759008409 binding surface 472759008410 TPR motif; other site 472759008411 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 472759008412 binding surface 472759008413 TPR motif; other site 472759008414 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 472759008415 TPR motif; other site 472759008416 binding surface 472759008417 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 472759008418 binding surface 472759008419 TPR motif; other site 472759008420 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 472759008421 TPR motif; other site 472759008422 binding surface 472759008423 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 472759008424 binding surface 472759008425 TPR motif; other site 472759008426 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 472759008427 TPR motif; other site 472759008428 binding surface 472759008429 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 472759008430 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 472759008431 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 472759008432 putative trimer interface [polypeptide binding]; other site 472759008433 putative CoA binding site [chemical binding]; other site 472759008434 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 472759008435 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 472759008436 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 472759008437 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 472759008438 HlyD family secretion protein; Region: HlyD_3; pfam13437 472759008439 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 472759008440 Protein export membrane protein; Region: SecD_SecF; cl14618 472759008441 hypothetical protein; Validated; Region: PRK08223 472759008442 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 472759008443 ATP binding site [chemical binding]; other site 472759008444 substrate interface [chemical binding]; other site 472759008445 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 472759008446 dimer interface [polypeptide binding]; other site 472759008447 N-acyl amino acid synthase, PEP-CTERM/exosortase system-associated; Region: exosort_acyl; TIGR03694 472759008448 N-acyl amino acid synthase, PEP-CTERM/exosortase system-associated; Region: exosort_acyl; TIGR03694 472759008449 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 472759008450 Haemagglutinin; Region: Hemagglutinin; pfam00509 472759008451 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 472759008452 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 472759008453 oligomeric interface; other site 472759008454 putative active site [active] 472759008455 homodimer interface [polypeptide binding]; other site 472759008456 PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915 472759008457 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 472759008458 active site 472759008459 phosphorylation site [posttranslational modification] 472759008460 intermolecular recognition site; other site 472759008461 dimerization interface [polypeptide binding]; other site 472759008462 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759008463 Walker A motif; other site 472759008464 ATP binding site [chemical binding]; other site 472759008465 Walker B motif; other site 472759008466 arginine finger; other site 472759008467 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 472759008468 putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916 472759008469 GAF domain; Region: GAF_3; pfam13492 472759008470 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 472759008471 dimer interface [polypeptide binding]; other site 472759008472 phosphorylation site [posttranslational modification] 472759008473 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 472759008474 ATP binding site [chemical binding]; other site 472759008475 Mg2+ binding site [ion binding]; other site 472759008476 G-X-G motif; other site 472759008477 sugar transferase, PEP-CTERM system associated; Region: EpsB_2; TIGR03013 472759008478 Bacterial sugar transferase; Region: Bac_transf; pfam02397 472759008479 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 472759008480 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 472759008481 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 472759008482 Bacterial SH3 domain homologues; Region: SH3b; smart00287 472759008483 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 472759008484 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 472759008485 Part of AAA domain; Region: AAA_19; pfam13245 472759008486 Family description; Region: UvrD_C_2; pfam13538 472759008487 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 472759008488 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 472759008489 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759008490 Walker A motif; other site 472759008491 ATP binding site [chemical binding]; other site 472759008492 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 472759008493 Membrane fusogenic activity; Region: BMFP; pfam04380 472759008494 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 472759008495 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 472759008496 Probable transposase; Region: OrfB_IS605; pfam01385 472759008497 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 472759008498 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 472759008499 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 472759008500 probable ammonium transporter, marine subtype; Region: marine_trans_1; TIGR03644 472759008501 N-acetylglutamate synthase; Validated; Region: PRK05279 472759008502 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 472759008503 putative feedback inhibition sensing region; other site 472759008504 putative nucleotide binding site [chemical binding]; other site 472759008505 putative substrate binding site [chemical binding]; other site 472759008506 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 472759008507 Coenzyme A binding pocket [chemical binding]; other site 472759008508 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 472759008509 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 472759008510 GatB domain; Region: GatB_Yqey; smart00845 472759008511 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 472759008512 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 472759008513 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 472759008514 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 472759008515 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759008516 Walker A motif; other site 472759008517 ATP binding site [chemical binding]; other site 472759008518 Walker B motif; other site 472759008519 arginine finger; other site 472759008520 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 472759008521 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 472759008522 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 472759008523 motif II; other site 472759008524 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 472759008525 putative active site [active] 472759008526 Ap4A binding site [chemical binding]; other site 472759008527 nudix motif; other site 472759008528 putative metal binding site [ion binding]; other site 472759008529 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 472759008530 putative active site [active] 472759008531 Ap4A binding site [chemical binding]; other site 472759008532 nudix motif; other site 472759008533 putative metal binding site [ion binding]; other site 472759008534 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 472759008535 Bacterial sugar transferase; Region: Bac_transf; pfam02397 472759008536 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 472759008537 Interdomain contacts; other site 472759008538 Cytokine receptor motif; other site 472759008539 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 472759008540 Interdomain contacts; other site 472759008541 Cytokine receptor motif; other site 472759008542 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 472759008543 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 472759008544 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 472759008545 catalytic triad [active] 472759008546 Putative Ig domain; Region: He_PIG; pfam05345 472759008547 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 472759008548 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 472759008549 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 472759008550 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 472759008551 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 472759008552 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 472759008553 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 472759008554 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 472759008555 Methyltransferase domain; Region: Methyltransf_31; pfam13847 472759008556 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759008557 S-adenosylmethionine binding site [chemical binding]; other site 472759008558 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 472759008559 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 472759008560 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 472759008561 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 472759008562 trimer interface [polypeptide binding]; other site 472759008563 active site 472759008564 substrate binding site [chemical binding]; other site 472759008565 CoA binding site [chemical binding]; other site 472759008566 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 472759008567 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 472759008568 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 472759008569 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 472759008570 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 472759008571 NAD(P) binding site [chemical binding]; other site 472759008572 active site 472759008573 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 472759008574 Methyltransferase domain; Region: Methyltransf_23; pfam13489 472759008575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759008576 S-adenosylmethionine binding site [chemical binding]; other site 472759008577 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 472759008578 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 472759008579 active site 472759008580 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 472759008581 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 472759008582 Probable Catalytic site; other site 472759008583 metal-binding site 472759008584 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 472759008585 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 472759008586 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 472759008587 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 472759008588 active site 472759008589 Methyltransferase domain; Region: Methyltransf_23; pfam13489 472759008590 Methyltransferase domain; Region: Methyltransf_11; pfam08241 472759008591 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 472759008592 DDE superfamily endonuclease; Region: DDE_3; pfam13358 472759008593 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 472759008594 Winged helix-turn helix; Region: HTH_29; pfam13551 472759008595 Helix-turn-helix domain; Region: HTH_28; pfam13518 472759008596 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 472759008597 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 472759008598 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 472759008599 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 472759008600 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 472759008601 active site 472759008602 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 472759008603 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 472759008604 Ligand binding site; other site 472759008605 Putative Catalytic site; other site 472759008606 DXD motif; other site 472759008607 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 472759008608 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 472759008609 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 472759008610 P-loop; other site 472759008611 Magnesium ion binding site [ion binding]; other site 472759008612 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 472759008613 Chain length determinant protein; Region: Wzz; cl15801 472759008614 uncharacterized protein, PEP-CTERM system associated; Region: pepcterm_hypo_1; TIGR03016 472759008615 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 472759008616 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 472759008617 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 472759008618 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 472759008619 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 472759008620 G1 box; other site 472759008621 GTP/Mg2+ binding site [chemical binding]; other site 472759008622 G2 box; other site 472759008623 Switch I region; other site 472759008624 G3 box; other site 472759008625 Switch II region; other site 472759008626 G4 box; other site 472759008627 G5 box; other site 472759008628 Response regulator receiver domain; Region: Response_reg; pfam00072 472759008629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 472759008630 active site 472759008631 phosphorylation site [posttranslational modification] 472759008632 intermolecular recognition site; other site 472759008633 dimerization interface [polypeptide binding]; other site 472759008634 Response regulator receiver domain; Region: Response_reg; pfam00072 472759008635 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 472759008636 active site 472759008637 phosphorylation site [posttranslational modification] 472759008638 intermolecular recognition site; other site 472759008639 dimerization interface [polypeptide binding]; other site 472759008640 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 472759008641 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 472759008642 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 472759008643 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 472759008644 dimer interface [polypeptide binding]; other site 472759008645 putative CheW interface [polypeptide binding]; other site 472759008646 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 472759008647 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759008648 S-adenosylmethionine binding site [chemical binding]; other site 472759008649 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 472759008650 putative binding surface; other site 472759008651 active site 472759008652 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 472759008653 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 472759008654 putative binding surface; other site 472759008655 active site 472759008656 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 472759008657 putative binding surface; other site 472759008658 active site 472759008659 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 472759008660 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 472759008661 ATP binding site [chemical binding]; other site 472759008662 Mg2+ binding site [ion binding]; other site 472759008663 G-X-G motif; other site 472759008664 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 472759008665 Response regulator receiver domain; Region: Response_reg; pfam00072 472759008666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 472759008667 active site 472759008668 phosphorylation site [posttranslational modification] 472759008669 intermolecular recognition site; other site 472759008670 dimerization interface [polypeptide binding]; other site 472759008671 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 472759008672 CheB methylesterase; Region: CheB_methylest; pfam01339 472759008673 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 472759008674 RNA methyltransferase, RsmE family; Region: TIGR00046 472759008675 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 472759008676 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK07030 472759008677 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 472759008678 inhibitor-cofactor binding pocket; inhibition site 472759008679 pyridoxal 5'-phosphate binding site [chemical binding]; other site 472759008680 catalytic residue [active] 472759008681 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 472759008682 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 472759008683 HlyD family secretion protein; Region: HlyD_3; pfam13437 472759008684 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 472759008685 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 472759008686 Walker A/P-loop; other site 472759008687 ATP binding site [chemical binding]; other site 472759008688 Q-loop/lid; other site 472759008689 ABC transporter signature motif; other site 472759008690 Walker B; other site 472759008691 D-loop; other site 472759008692 H-loop/switch region; other site 472759008693 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 472759008694 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 472759008695 FtsX-like permease family; Region: FtsX; pfam02687 472759008696 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 472759008697 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 472759008698 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 472759008699 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 472759008700 C factor cell-cell signaling protein; Provisional; Region: PRK09009 472759008701 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 472759008702 NADP binding site [chemical binding]; other site 472759008703 homodimer interface [polypeptide binding]; other site 472759008704 active site 472759008705 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 472759008706 Low molecular weight phosphatase family; Region: LMWPc; cd00115 472759008707 active site 472759008708 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 472759008709 putative metal binding site [ion binding]; other site 472759008710 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 472759008711 dimerization interface [polypeptide binding]; other site 472759008712 putative DNA binding site [nucleotide binding]; other site 472759008713 putative Zn2+ binding site [ion binding]; other site 472759008714 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 472759008715 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 472759008716 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 472759008717 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 472759008718 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 472759008719 Predicted transcriptional regulator [Transcription]; Region: COG5340 472759008720 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 472759008721 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 472759008722 Domain of unknown function DUF87; Region: DUF87; pfam01935 472759008723 HerA helicase [Replication, recombination, and repair]; Region: COG0433 472759008724 SIR2-like domain; Region: SIR2_2; pfam13289 472759008725 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 472759008726 DNA methylase; Region: N6_N4_Mtase; cl17433 472759008727 DNA methylase; Region: N6_N4_Mtase; pfam01555 472759008728 DNA methylase; Region: N6_N4_Mtase; cl17433 472759008729 Restriction endonuclease [Defense mechanisms]; Region: COG3587 472759008730 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 472759008731 ATP binding site [chemical binding]; other site 472759008732 putative Mg++ binding site [ion binding]; other site 472759008733 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 472759008734 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 472759008735 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 472759008736 putative addiction module antidote; Region: doc_partner; TIGR02609 472759008737 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 472759008738 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 472759008739 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 472759008740 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 472759008741 putative active site [active] 472759008742 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 472759008743 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 472759008744 putative ADP-binding pocket [chemical binding]; other site 472759008745 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 472759008746 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 472759008747 putative active site [active] 472759008748 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 472759008749 O-Antigen ligase; Region: Wzy_C; pfam04932 472759008750 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 472759008751 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 472759008752 putative active site [active] 472759008753 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 472759008754 This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819 472759008755 putative ADP-binding pocket [chemical binding]; other site 472759008756 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 472759008757 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 472759008758 spermidine synthase; Provisional; Region: PRK00811 472759008759 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759008760 S-adenosylmethionine binding site [chemical binding]; other site 472759008761 arginine decarboxylase; Provisional; Region: PRK05354 472759008762 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 472759008763 dimer interface [polypeptide binding]; other site 472759008764 active site 472759008765 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 472759008766 catalytic residues [active] 472759008767 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 472759008768 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 472759008769 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 472759008770 DNA polymerase I; Provisional; Region: PRK05755 472759008771 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 472759008772 active site 472759008773 metal binding site 1 [ion binding]; metal-binding site 472759008774 putative 5' ssDNA interaction site; other site 472759008775 metal binding site 3; metal-binding site 472759008776 metal binding site 2 [ion binding]; metal-binding site 472759008777 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 472759008778 putative DNA binding site [nucleotide binding]; other site 472759008779 putative metal binding site [ion binding]; other site 472759008780 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 472759008781 active site 472759008782 catalytic site [active] 472759008783 substrate binding site [chemical binding]; other site 472759008784 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 472759008785 active site 472759008786 DNA binding site [nucleotide binding] 472759008787 catalytic site [active] 472759008788 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 472759008789 G1 box; other site 472759008790 GTP/Mg2+ binding site [chemical binding]; other site 472759008791 Switch I region; other site 472759008792 G2 box; other site 472759008793 G3 box; other site 472759008794 Switch II region; other site 472759008795 G4 box; other site 472759008796 G5 box; other site 472759008797 Cytochrome c553 [Energy production and conversion]; Region: COG2863 472759008798 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 472759008799 Cytochrome c; Region: Cytochrom_C; cl11414 472759008800 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 472759008801 catalytic residues [active] 472759008802 hinge region; other site 472759008803 alpha helical domain; other site 472759008804 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 472759008805 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 472759008806 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 472759008807 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 472759008808 dimerization interface [polypeptide binding]; other site 472759008809 putative DNA binding site [nucleotide binding]; other site 472759008810 putative Zn2+ binding site [ion binding]; other site 472759008811 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 472759008812 active site 472759008813 NTP binding site [chemical binding]; other site 472759008814 metal binding triad [ion binding]; metal-binding site 472759008815 antibiotic binding site [chemical binding]; other site 472759008816 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 472759008817 ADP-ribose binding site [chemical binding]; other site 472759008818 Protein of unknown function DUF45; Region: DUF45; pfam01863 472759008819 short chain dehydrogenase; Provisional; Region: PRK07326 472759008820 classical (c) SDRs; Region: SDR_c; cd05233 472759008821 NAD(P) binding site [chemical binding]; other site 472759008822 active site 472759008823 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 472759008824 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 472759008825 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 472759008826 Ligand binding site; other site 472759008827 oligomer interface; other site 472759008828 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 472759008829 Low molecular weight phosphatase family; Region: LMWPc; cd00115 472759008830 active site 472759008831 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 472759008832 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 472759008833 homodimer interface [polypeptide binding]; other site 472759008834 oligonucleotide binding site [chemical binding]; other site 472759008835 recombination factor protein RarA; Reviewed; Region: PRK13342 472759008836 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759008837 Walker A motif; other site 472759008838 ATP binding site [chemical binding]; other site 472759008839 Walker B motif; other site 472759008840 arginine finger; other site 472759008841 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 472759008842 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 472759008843 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 472759008844 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 472759008845 Extracellular matrix protein 1 (ECM1); Region: ECM1; pfam05782 472759008846 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 472759008847 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 472759008848 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 472759008849 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 472759008850 hexamer interface [polypeptide binding]; other site 472759008851 ligand binding site [chemical binding]; other site 472759008852 putative active site [active] 472759008853 NAD(P) binding site [chemical binding]; other site 472759008854 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 472759008855 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 472759008856 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 472759008857 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 472759008858 Cytochrome c; Region: Cytochrom_C; cl11414 472759008859 Peptidase family M48; Region: Peptidase_M48; pfam01435 472759008860 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 472759008861 catalytic site [active] 472759008862 putative active site [active] 472759008863 putative substrate binding site [chemical binding]; other site 472759008864 dimer interface [polypeptide binding]; other site 472759008865 epoxyqueuosine reductase; Region: TIGR00276 472759008866 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 472759008867 putative carbohydrate kinase; Provisional; Region: PRK10565 472759008868 Uncharacterized conserved protein [Function unknown]; Region: COG0062 472759008869 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 472759008870 putative substrate binding site [chemical binding]; other site 472759008871 putative ATP binding site [chemical binding]; other site 472759008872 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 472759008873 AMIN domain; Region: AMIN; pfam11741 472759008874 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 472759008875 active site 472759008876 metal binding site [ion binding]; metal-binding site 472759008877 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 472759008878 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 472759008879 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 472759008880 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 472759008881 ATP binding site [chemical binding]; other site 472759008882 Mg2+ binding site [ion binding]; other site 472759008883 G-X-G motif; other site 472759008884 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 472759008885 ATP binding site [chemical binding]; other site 472759008886 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 472759008887 PAS domain S-box; Region: sensory_box; TIGR00229 472759008888 PAS domain; Region: PAS; smart00091 472759008889 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 472759008890 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 472759008891 metal binding site [ion binding]; metal-binding site 472759008892 active site 472759008893 I-site; other site 472759008894 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 472759008895 Transcriptional regulator [Transcription]; Region: LysR; COG0583 472759008896 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 472759008897 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 472759008898 putative dimerization interface [polypeptide binding]; other site 472759008899 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 472759008900 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 472759008901 dimer interface [polypeptide binding]; other site 472759008902 catalytic residue [active] 472759008903 metal binding site [ion binding]; metal-binding site 472759008904 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 472759008905 multimerization interface [polypeptide binding]; other site 472759008906 MoxR-like ATPases [General function prediction only]; Region: COG0714 472759008907 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 472759008908 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 472759008909 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 472759008910 metal ion-dependent adhesion site (MIDAS); other site 472759008911 ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040 472759008912 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 472759008913 homodimer interface [polypeptide binding]; other site 472759008914 active site 472759008915 heterodimer interface [polypeptide binding]; other site 472759008916 catalytic residue [active] 472759008917 metal binding site [ion binding]; metal-binding site 472759008918 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 472759008919 multimerization interface [polypeptide binding]; other site 472759008920 CbbX; Provisional; Region: cbbX; CHL00181 472759008921 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759008922 Walker A motif; other site 472759008923 ATP binding site [chemical binding]; other site 472759008924 Walker B motif; other site 472759008925 arginine finger; other site 472759008926 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 472759008927 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 472759008928 intersubunit interface [polypeptide binding]; other site 472759008929 active site 472759008930 zinc binding site [ion binding]; other site 472759008931 Na+ binding site [ion binding]; other site 472759008932 pyruvate kinase; Provisional; Region: PRK05826 472759008933 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 472759008934 domain interfaces; other site 472759008935 active site 472759008936 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 472759008937 Phosphoglycerate kinase; Region: PGK; pfam00162 472759008938 substrate binding site [chemical binding]; other site 472759008939 hinge regions; other site 472759008940 ADP binding site [chemical binding]; other site 472759008941 catalytic site [active] 472759008942 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 472759008943 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 472759008944 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 472759008945 transketolase; Reviewed; Region: PRK12753 472759008946 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 472759008947 TPP-binding site [chemical binding]; other site 472759008948 dimer interface [polypeptide binding]; other site 472759008949 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 472759008950 PYR/PP interface [polypeptide binding]; other site 472759008951 dimer interface [polypeptide binding]; other site 472759008952 TPP binding site [chemical binding]; other site 472759008953 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 472759008954 dihydrodipicolinate reductase; Provisional; Region: PRK00048 472759008955 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 472759008956 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 472759008957 chaperone protein DnaJ; Provisional; Region: PRK10767 472759008958 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 472759008959 HSP70 interaction site [polypeptide binding]; other site 472759008960 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 472759008961 substrate binding site [polypeptide binding]; other site 472759008962 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 472759008963 Zn binding sites [ion binding]; other site 472759008964 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 472759008965 dimer interface [polypeptide binding]; other site 472759008966 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 472759008967 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 472759008968 nucleotide binding site [chemical binding]; other site 472759008969 GrpE; Region: GrpE; pfam01025 472759008970 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 472759008971 dimer interface [polypeptide binding]; other site 472759008972 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 472759008973 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 472759008974 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 472759008975 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 472759008976 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 472759008977 active site 472759008978 catalytic site [active] 472759008979 substrate binding site [chemical binding]; other site 472759008980 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 472759008981 RNA/DNA hybrid binding site [nucleotide binding]; other site 472759008982 active site 472759008983 Methyltransferase domain; Region: Methyltransf_11; pfam08241 472759008984 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 472759008985 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 472759008986 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 472759008987 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 472759008988 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 472759008989 heterodimer interface [polypeptide binding]; other site 472759008990 active site 472759008991 FMN binding site [chemical binding]; other site 472759008992 homodimer interface [polypeptide binding]; other site 472759008993 substrate binding site [chemical binding]; other site 472759008994 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 472759008995 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 472759008996 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 472759008997 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 472759008998 phosphoribulokinase; Provisional; Region: PRK15453 472759008999 active site 472759009000 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 472759009001 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 472759009002 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 472759009003 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 472759009004 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 472759009005 ThiC-associated domain; Region: ThiC-associated; pfam13667 472759009006 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 472759009007 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 472759009008 putative DNA-binding cleft [nucleotide binding]; other site 472759009009 putative DNA clevage site; other site 472759009010 molecular lever; other site 472759009011 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 472759009012 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 472759009013 Walker A/P-loop; other site 472759009014 ATP binding site [chemical binding]; other site 472759009015 Q-loop/lid; other site 472759009016 ABC transporter signature motif; other site 472759009017 Walker B; other site 472759009018 D-loop; other site 472759009019 H-loop/switch region; other site 472759009020 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 472759009021 inner membrane transport permease; Provisional; Region: PRK15066 472759009022 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 472759009023 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 472759009024 23S rRNA interface [nucleotide binding]; other site 472759009025 L3 interface [polypeptide binding]; other site 472759009026 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 472759009027 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 472759009028 non-specific DNA binding site [nucleotide binding]; other site 472759009029 salt bridge; other site 472759009030 sequence-specific DNA binding site [nucleotide binding]; other site 472759009031 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 472759009032 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 472759009033 non-specific DNA binding site [nucleotide binding]; other site 472759009034 salt bridge; other site 472759009035 sequence-specific DNA binding site [nucleotide binding]; other site 472759009036 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 472759009037 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 472759009038 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 472759009039 TrkA-N domain; Region: TrkA_N; pfam02254 472759009040 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 472759009041 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 472759009042 dimer interface [polypeptide binding]; other site 472759009043 pyridoxal 5'-phosphate binding site [chemical binding]; other site 472759009044 catalytic residue [active] 472759009045 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 472759009046 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 472759009047 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 472759009048 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 472759009049 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 472759009050 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 472759009051 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 472759009052 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 472759009053 NAD(P) binding site [chemical binding]; other site 472759009054 catalytic residues [active] 472759009055 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 472759009056 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 472759009057 tetramer interface [polypeptide binding]; other site 472759009058 pyridoxal 5'-phosphate binding site [chemical binding]; other site 472759009059 catalytic residue [active] 472759009060 acetylornithine deacetylase; Provisional; Region: PRK07522 472759009061 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 472759009062 metal binding site [ion binding]; metal-binding site 472759009063 putative dimer interface [polypeptide binding]; other site 472759009064 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 472759009065 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 472759009066 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 472759009067 active site 472759009068 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 472759009069 DNA-binding site [nucleotide binding]; DNA binding site 472759009070 RNA-binding motif; other site 472759009071 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 472759009072 RNA recognition motif; Region: RRM; smart00360 472759009073 helicase 45; Provisional; Region: PTZ00424 472759009074 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 472759009075 ATP binding site [chemical binding]; other site 472759009076 Mg++ binding site [ion binding]; other site 472759009077 motif III; other site 472759009078 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 472759009079 nucleotide binding region [chemical binding]; other site 472759009080 ATP-binding site [chemical binding]; other site 472759009081 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 472759009082 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 472759009083 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 472759009084 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 472759009085 putative ribose interaction site [chemical binding]; other site 472759009086 putative ADP binding site [chemical binding]; other site 472759009087 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 472759009088 active site 472759009089 nucleotide binding site [chemical binding]; other site 472759009090 HIGH motif; other site 472759009091 KMSKS motif; other site 472759009092 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 472759009093 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 472759009094 NADP binding site [chemical binding]; other site 472759009095 homopentamer interface [polypeptide binding]; other site 472759009096 substrate binding site [chemical binding]; other site 472759009097 active site 472759009098 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 472759009099 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 472759009100 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 472759009101 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 472759009102 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 472759009103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759009104 S-adenosylmethionine binding site [chemical binding]; other site 472759009105 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 472759009106 CPxP motif; other site 472759009107 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 472759009108 Peptidase family M48; Region: Peptidase_M48; pfam01435 472759009109 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 472759009110 TPR motif; other site 472759009111 binding surface 472759009112 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 472759009113 binding surface 472759009114 TPR motif; other site 472759009115 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 472759009116 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 472759009117 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 472759009118 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 472759009119 pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079 472759009120 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 472759009121 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 472759009122 FeS/SAM binding site; other site 472759009123 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 472759009124 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 472759009125 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 472759009126 Walker A/P-loop; other site 472759009127 ATP binding site [chemical binding]; other site 472759009128 Q-loop/lid; other site 472759009129 ABC transporter signature motif; other site 472759009130 Walker B; other site 472759009131 D-loop; other site 472759009132 H-loop/switch region; other site 472759009133 ABC-2 type transporter; Region: ABC2_membrane; cl17235 472759009134 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 472759009135 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 472759009136 Kelch motif; Region: Kelch_1; pfam01344 472759009137 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 472759009138 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 472759009139 Kelch motif; Region: Kelch_1; pfam01344 472759009140 Kelch motif; Region: Kelch_6; pfam13964 472759009141 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 472759009142 Kelch domain; Region: Kelch; smart00612 472759009143 Galactose oxidase, central domain; Region: Kelch_3; cl02701 472759009144 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 472759009145 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 472759009146 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 472759009147 trimer interface [polypeptide binding]; other site 472759009148 active site 472759009149 UDP-GlcNAc binding site [chemical binding]; other site 472759009150 lipid binding site [chemical binding]; lipid-binding site 472759009151 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 472759009152 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 472759009153 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 472759009154 HicB family; Region: HicB; pfam05534 472759009155 DNA repair protein RadA; Provisional; Region: PRK11823 472759009156 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 472759009157 Walker A motif; other site 472759009158 ATP binding site [chemical binding]; other site 472759009159 Walker B motif; other site 472759009160 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 472759009161 alanine racemase; Reviewed; Region: alr; PRK00053 472759009162 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 472759009163 active site 472759009164 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 472759009165 substrate binding site [chemical binding]; other site 472759009166 catalytic residues [active] 472759009167 dimer interface [polypeptide binding]; other site 472759009168 replicative DNA helicase; Region: DnaB; TIGR00665 472759009169 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 472759009170 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 472759009171 Walker A motif; other site 472759009172 ATP binding site [chemical binding]; other site 472759009173 Walker B motif; other site 472759009174 DNA binding loops [nucleotide binding] 472759009175 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 472759009176 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 472759009177 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 472759009178 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 472759009179 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 472759009180 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 472759009181 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 472759009182 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 472759009183 PAS domain S-box; Region: sensory_box; TIGR00229 472759009184 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 472759009185 putative active site [active] 472759009186 GAF domain; Region: GAF; pfam01590 472759009187 GAF domain; Region: GAF_2; pfam13185 472759009188 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 472759009189 dimer interface [polypeptide binding]; other site 472759009190 phosphorylation site [posttranslational modification] 472759009191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 472759009192 ATP binding site [chemical binding]; other site 472759009193 Mg2+ binding site [ion binding]; other site 472759009194 G-X-G motif; other site 472759009195 Response regulator receiver domain; Region: Response_reg; pfam00072 472759009196 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 472759009197 active site 472759009198 phosphorylation site [posttranslational modification] 472759009199 intermolecular recognition site; other site 472759009200 dimerization interface [polypeptide binding]; other site 472759009201 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 472759009202 trehalose synthase; Region: treS_nterm; TIGR02456 472759009203 active site 472759009204 catalytic site [active] 472759009205 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 472759009206 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 472759009207 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 472759009208 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 472759009209 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 472759009210 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 472759009211 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 472759009212 Active_site [active] 472759009213 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 472759009214 MPT binding site; other site 472759009215 trimer interface [polypeptide binding]; other site 472759009216 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 472759009217 Transposase IS200 like; Region: Y1_Tnp; cl00848 472759009218 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 472759009219 Ca2+ binding site [ion binding]; other site 472759009220 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 472759009221 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 472759009222 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 472759009223 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 472759009224 dimer interface [polypeptide binding]; other site 472759009225 phosphorylation site [posttranslational modification] 472759009226 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 472759009227 ATP binding site [chemical binding]; other site 472759009228 Mg2+ binding site [ion binding]; other site 472759009229 G-X-G motif; other site 472759009230 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 472759009231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 472759009232 active site 472759009233 phosphorylation site [posttranslational modification] 472759009234 intermolecular recognition site; other site 472759009235 dimerization interface [polypeptide binding]; other site 472759009236 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759009237 Walker A motif; other site 472759009238 ATP binding site [chemical binding]; other site 472759009239 Walker B motif; other site 472759009240 arginine finger; other site 472759009241 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 472759009242 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 472759009243 cyclase homology domain; Region: CHD; cd07302 472759009244 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 472759009245 nucleotidyl binding site; other site 472759009246 metal binding site [ion binding]; metal-binding site 472759009247 dimer interface [polypeptide binding]; other site 472759009248 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 472759009249 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 472759009250 ligand binding site [chemical binding]; other site 472759009251 flexible hinge region; other site 472759009252 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 472759009253 putative switch regulator; other site 472759009254 non-specific DNA interactions [nucleotide binding]; other site 472759009255 DNA binding site [nucleotide binding] 472759009256 sequence specific DNA binding site [nucleotide binding]; other site 472759009257 putative cAMP binding site [chemical binding]; other site 472759009258 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 472759009259 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 472759009260 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 472759009261 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 472759009262 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 472759009263 dimer interface [polypeptide binding]; other site 472759009264 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 472759009265 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 472759009266 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 472759009267 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 472759009268 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 472759009269 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 472759009270 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 472759009271 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 472759009272 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 472759009273 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 472759009274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 472759009275 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 472759009276 DsbD alpha interface [polypeptide binding]; other site 472759009277 catalytic residues [active] 472759009278 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 472759009279 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 472759009280 catalytic residues [active] 472759009281 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 472759009282 Dehydroquinase class II; Region: DHquinase_II; pfam01220 472759009283 trimer interface [polypeptide binding]; other site 472759009284 active site 472759009285 dimer interface [polypeptide binding]; other site 472759009286 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 472759009287 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 472759009288 carboxyltransferase (CT) interaction site; other site 472759009289 biotinylation site [posttranslational modification]; other site 472759009290 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 472759009291 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 472759009292 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 472759009293 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 472759009294 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 472759009295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759009296 S-adenosylmethionine binding site [chemical binding]; other site 472759009297 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 472759009298 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 472759009299 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 472759009300 purine monophosphate binding site [chemical binding]; other site 472759009301 dimer interface [polypeptide binding]; other site 472759009302 putative catalytic residues [active] 472759009303 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 472759009304 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 472759009305 adenylate cyclase; Provisional; Region: cyaA; PRK09450 472759009306 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 472759009307 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 472759009308 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 472759009309 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 472759009310 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 472759009311 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 472759009312 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 472759009313 dimer interface [polypeptide binding]; other site 472759009314 [2Fe-2S] cluster binding site [ion binding]; other site 472759009315 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 472759009316 active site lid residues [active] 472759009317 substrate binding pocket [chemical binding]; other site 472759009318 catalytic residues [active] 472759009319 substrate-Mg2+ binding site; other site 472759009320 aspartate-rich region 1; other site 472759009321 aspartate-rich region 2; other site 472759009322 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 472759009323 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 472759009324 RNA binding surface [nucleotide binding]; other site 472759009325 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 472759009326 probable active site [active] 472759009327 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 472759009328 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 472759009329 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 472759009330 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 472759009331 active site 472759009332 HIGH motif; other site 472759009333 dimer interface [polypeptide binding]; other site 472759009334 KMSKS motif; other site 472759009335 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 472759009336 Peptidase family M50; Region: Peptidase_M50; pfam02163 472759009337 active site 472759009338 seryl-tRNA synthetase; Provisional; Region: PRK05431 472759009339 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 472759009340 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 472759009341 dimer interface [polypeptide binding]; other site 472759009342 active site 472759009343 motif 1; other site 472759009344 motif 2; other site 472759009345 motif 3; other site 472759009346 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 472759009347 NlpC/P60 family; Region: NLPC_P60; pfam00877 472759009348 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 472759009349 TrkA-C domain; Region: TrkA_C; pfam02080 472759009350 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 472759009351 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 472759009352 catalytic triad [active] 472759009353 threonine dehydratase; Provisional; Region: PRK07334 472759009354 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 472759009355 tetramer interface [polypeptide binding]; other site 472759009356 pyridoxal 5'-phosphate binding site [chemical binding]; other site 472759009357 catalytic residue [active] 472759009358 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 472759009359 ATP-grasp domain; Region: ATP-grasp_4; cl17255 472759009360 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 472759009361 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 472759009362 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 472759009363 ATP-grasp domain; Region: ATP-grasp_4; cl17255 472759009364 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 472759009365 putative cation:proton antiport protein; Provisional; Region: PRK10669 472759009366 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 472759009367 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 472759009368 TrkA-N domain; Region: TrkA_N; pfam02254 472759009369 TrkA-C domain; Region: TrkA_C; pfam02080 472759009370 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 472759009371 elongation factor G; Reviewed; Region: PRK12740 472759009372 G1 box; other site 472759009373 putative GEF interaction site [polypeptide binding]; other site 472759009374 GTP/Mg2+ binding site [chemical binding]; other site 472759009375 Switch I region; other site 472759009376 G2 box; other site 472759009377 G3 box; other site 472759009378 Switch II region; other site 472759009379 G4 box; other site 472759009380 G5 box; other site 472759009381 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 472759009382 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 472759009383 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 472759009384 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 472759009385 aromatic arch; other site 472759009386 DCoH dimer interaction site [polypeptide binding]; other site 472759009387 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 472759009388 DCoH tetramer interaction site [polypeptide binding]; other site 472759009389 substrate binding site [chemical binding]; other site 472759009390 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 472759009391 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 472759009392 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 472759009393 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 472759009394 metal binding site [ion binding]; metal-binding site 472759009395 active site 472759009396 I-site; other site 472759009397 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 472759009398 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 472759009399 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 472759009400 substrate binding pocket [chemical binding]; other site 472759009401 chain length determination region; other site 472759009402 substrate-Mg2+ binding site; other site 472759009403 catalytic residues [active] 472759009404 aspartate-rich region 1; other site 472759009405 active site lid residues [active] 472759009406 aspartate-rich region 2; other site 472759009407 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 472759009408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759009409 S-adenosylmethionine binding site [chemical binding]; other site 472759009410 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 472759009411 hypothetical protein; Provisional; Region: PRK11281 472759009412 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 472759009413 Mechanosensitive ion channel; Region: MS_channel; pfam00924 472759009414 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 472759009415 Putative transmembrane protein (PGPGW); Region: PGPGW; pfam09656 472759009416 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 472759009417 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 472759009418 FeS/SAM binding site; other site 472759009419 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 472759009420 putative ligand binding pocket/active site [active] 472759009421 putative metal binding site [ion binding]; other site 472759009422 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 472759009423 AMMECR1; Region: AMMECR1; pfam01871 472759009424 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 472759009425 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 472759009426 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 472759009427 Protein of unknown function (DUF2802); Region: DUF2802; pfam10975 472759009428 flagellar motor protein MotD; Reviewed; Region: PRK09038 472759009429 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 472759009430 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 472759009431 ligand binding site [chemical binding]; other site 472759009432 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 472759009433 flagellar motor protein; Reviewed; Region: motC; PRK09109 472759009434 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 472759009435 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 472759009436 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 472759009437 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 472759009438 DNA binding residues [nucleotide binding] 472759009439 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 472759009440 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 472759009441 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 472759009442 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 472759009443 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 472759009444 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 472759009445 FHIPEP family; Region: FHIPEP; pfam00771 472759009446 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 472759009447 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 472759009448 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 472759009449 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 472759009450 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 472759009451 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 472759009452 flagellar motor switch protein; Validated; Region: fliN; PRK05698 472759009453 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 472759009454 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 472759009455 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 472759009456 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 472759009457 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 472759009458 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 472759009459 putative NAD(P) binding site [chemical binding]; other site 472759009460 active site 472759009461 putative substrate binding site [chemical binding]; other site 472759009462 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 472759009463 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 472759009464 Probable Catalytic site; other site 472759009465 metal-binding site 472759009466 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 472759009467 putative active site [active] 472759009468 putative catalytic triad [active] 472759009469 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 472759009470 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 472759009471 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 472759009472 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 472759009473 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 472759009474 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 472759009475 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 472759009476 Methyltransferase domain; Region: Methyltransf_24; pfam13578 472759009477 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 472759009478 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 472759009479 active site 472759009480 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 472759009481 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 472759009482 Ligand binding site; other site 472759009483 Methyltransferase domain; Region: Methyltransf_23; pfam13489 472759009484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759009485 S-adenosylmethionine binding site [chemical binding]; other site 472759009486 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 472759009487 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 472759009488 Probable Catalytic site; other site 472759009489 metal-binding site 472759009490 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 472759009491 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 472759009492 Methyltransferase domain; Region: Methyltransf_23; pfam13489 472759009493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759009494 S-adenosylmethionine binding site [chemical binding]; other site 472759009495 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 472759009496 putative acyl-acceptor binding pocket; other site 472759009497 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 472759009498 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 472759009499 Walker A/P-loop; other site 472759009500 ATP binding site [chemical binding]; other site 472759009501 Q-loop/lid; other site 472759009502 ABC transporter signature motif; other site 472759009503 Walker B; other site 472759009504 D-loop; other site 472759009505 H-loop/switch region; other site 472759009506 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 472759009507 putative carbohydrate binding site [chemical binding]; other site 472759009508 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 472759009509 ABC-2 type transporter; Region: ABC2_membrane; cl17235 472759009510 YcfA-like protein; Region: YcfA; cl00752 472759009511 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 472759009512 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 472759009513 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 472759009514 putative active site [active] 472759009515 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 472759009516 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 472759009517 Probable transposase; Region: OrfB_IS605; pfam01385 472759009518 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 472759009519 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 472759009520 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 472759009521 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 472759009522 type II secretion system protein D; Region: type_II_gspD; TIGR02517 472759009523 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 472759009524 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 472759009525 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 472759009526 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 472759009527 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 472759009528 Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741 472759009529 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 472759009530 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 472759009531 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 472759009532 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 472759009533 general secretion pathway protein J; Validated; Region: PRK08808 472759009534 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 472759009535 TPR motif; other site 472759009536 TPR repeat; Region: TPR_11; pfam13414 472759009537 binding surface 472759009538 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 472759009539 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 472759009540 Ligand binding site; other site 472759009541 Putative Catalytic site; other site 472759009542 DXD motif; other site 472759009543 Cytochrome c553 [Energy production and conversion]; Region: COG2863 472759009544 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 472759009545 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 472759009546 putative ADP-binding pocket [chemical binding]; other site 472759009547 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 472759009548 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 472759009549 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 472759009550 Probable Catalytic site; other site 472759009551 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 472759009552 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 472759009553 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 472759009554 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 472759009555 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 472759009556 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 472759009557 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 472759009558 Walker A/P-loop; other site 472759009559 ATP binding site [chemical binding]; other site 472759009560 Q-loop/lid; other site 472759009561 ABC transporter signature motif; other site 472759009562 Walker B; other site 472759009563 D-loop; other site 472759009564 H-loop/switch region; other site 472759009565 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 472759009566 ABC-2 type transporter; Region: ABC2_membrane; cl17235 472759009567 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 472759009568 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 472759009569 Probable Catalytic site; other site 472759009570 metal-binding site 472759009571 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 472759009572 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 472759009573 active site 472759009574 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 472759009575 Methyltransferase domain; Region: Methyltransf_12; pfam08242 472759009576 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 472759009577 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759009578 S-adenosylmethionine binding site [chemical binding]; other site 472759009579 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 472759009580 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 472759009581 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 472759009582 tetramer interface [polypeptide binding]; other site 472759009583 pyridoxal 5'-phosphate binding site [chemical binding]; other site 472759009584 catalytic residue [active] 472759009585 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 472759009586 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 472759009587 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 472759009588 substrate binding site [chemical binding]; other site 472759009589 ATP binding site [chemical binding]; other site 472759009590 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 472759009591 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 472759009592 catalytic residues [active] 472759009593 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 472759009594 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 472759009595 RNA binding surface [nucleotide binding]; other site 472759009596 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 472759009597 active site 472759009598 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 472759009599 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 472759009600 putative NAD(P) binding site [chemical binding]; other site 472759009601 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 472759009602 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 472759009603 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 472759009604 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 472759009605 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 472759009606 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 472759009607 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 472759009608 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 472759009609 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 472759009610 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 472759009611 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 472759009612 4Fe-4S binding domain; Region: Fer4; cl02805 472759009613 4Fe-4S binding domain; Region: Fer4; pfam00037 472759009614 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 472759009615 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 472759009616 NADH dehydrogenase subunit G; Validated; Region: PRK09129 472759009617 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 472759009618 catalytic loop [active] 472759009619 iron binding site [ion binding]; other site 472759009620 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 472759009621 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 472759009622 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 472759009623 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 472759009624 SLBB domain; Region: SLBB; pfam10531 472759009625 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 472759009626 NADH dehydrogenase subunit E; Validated; Region: PRK07539 472759009627 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 472759009628 putative dimer interface [polypeptide binding]; other site 472759009629 [2Fe-2S] cluster binding site [ion binding]; other site 472759009630 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 472759009631 NADH dehydrogenase subunit D; Validated; Region: PRK06075 472759009632 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 472759009633 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 472759009634 NADH dehydrogenase subunit B; Validated; Region: PRK06411 472759009635 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 472759009636 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 472759009637 triosephosphate isomerase; Provisional; Region: PRK14567 472759009638 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 472759009639 substrate binding site [chemical binding]; other site 472759009640 dimer interface [polypeptide binding]; other site 472759009641 catalytic triad [active] 472759009642 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 472759009643 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 472759009644 active site 472759009645 substrate binding site [chemical binding]; other site 472759009646 metal binding site [ion binding]; metal-binding site 472759009647 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 472759009648 dihydropteroate synthase; Region: DHPS; TIGR01496 472759009649 substrate binding pocket [chemical binding]; other site 472759009650 dimer interface [polypeptide binding]; other site 472759009651 inhibitor binding site; inhibition site 472759009652 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 472759009653 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759009654 Walker A motif; other site 472759009655 ATP binding site [chemical binding]; other site 472759009656 Walker B motif; other site 472759009657 arginine finger; other site 472759009658 Peptidase family M41; Region: Peptidase_M41; pfam01434 472759009659 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 472759009660 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759009661 S-adenosylmethionine binding site [chemical binding]; other site 472759009662 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 472759009663 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 472759009664 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 472759009665 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 472759009666 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 472759009667 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 472759009668 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 472759009669 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 472759009670 ATP-grasp domain; Region: ATP-grasp_4; cl17255 472759009671 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 472759009672 IMP binding site; other site 472759009673 dimer interface [polypeptide binding]; other site 472759009674 interdomain contacts; other site 472759009675 partial ornithine binding site; other site 472759009676 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 472759009677 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 472759009678 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 472759009679 catalytic site [active] 472759009680 subunit interface [polypeptide binding]; other site 472759009681 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 472759009682 dimer interface [polypeptide binding]; other site 472759009683 active site 472759009684 aspartate-rich active site metal binding site; other site 472759009685 allosteric magnesium binding site [ion binding]; other site 472759009686 Schiff base residues; other site 472759009687 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 472759009688 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 472759009689 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 472759009690 shikimate binding site; other site 472759009691 NAD(P) binding site [chemical binding]; other site 472759009692 Cell division protein ZapA; Region: ZapA; pfam05164 472759009693 TIGR02449 family protein; Region: TIGR02449 472759009694 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 472759009695 proline aminopeptidase P II; Provisional; Region: PRK10879 472759009696 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 472759009697 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 472759009698 active site 472759009699 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 472759009700 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 472759009701 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 472759009702 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 472759009703 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 472759009704 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 472759009705 ATP binding site [chemical binding]; other site 472759009706 Mg++ binding site [ion binding]; other site 472759009707 motif III; other site 472759009708 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 472759009709 nucleotide binding region [chemical binding]; other site 472759009710 ATP-binding site [chemical binding]; other site 472759009711 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 472759009712 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 472759009713 catalytic residues [active] 472759009714 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 472759009715 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 472759009716 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 472759009717 GDP-binding site [chemical binding]; other site 472759009718 ACT binding site; other site 472759009719 IMP binding site; other site 472759009720 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 472759009721 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 472759009722 dimer interface [polypeptide binding]; other site 472759009723 motif 1; other site 472759009724 active site 472759009725 motif 2; other site 472759009726 motif 3; other site 472759009727 FtsH protease regulator HflC; Provisional; Region: PRK11029 472759009728 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 472759009729 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 472759009730 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 472759009731 HflK protein; Region: hflK; TIGR01933 472759009732 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 472759009733 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 472759009734 HflX GTPase family; Region: HflX; cd01878 472759009735 G1 box; other site 472759009736 GTP/Mg2+ binding site [chemical binding]; other site 472759009737 Switch I region; other site 472759009738 G2 box; other site 472759009739 G3 box; other site 472759009740 Switch II region; other site 472759009741 G4 box; other site 472759009742 G5 box; other site 472759009743 bacterial Hfq-like; Region: Hfq; cd01716 472759009744 hexamer interface [polypeptide binding]; other site 472759009745 Sm1 motif; other site 472759009746 RNA binding site [nucleotide binding]; other site 472759009747 Sm2 motif; other site 472759009748 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 472759009749 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 472759009750 transcription termination factor Rho; Provisional; Region: rho; PRK09376 472759009751 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 472759009752 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 472759009753 RNA binding site [nucleotide binding]; other site 472759009754 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 472759009755 multimer interface [polypeptide binding]; other site 472759009756 Walker A motif; other site 472759009757 ATP binding site [chemical binding]; other site 472759009758 Walker B motif; other site 472759009759 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14969 472759009760 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759009761 Walker A motif; other site 472759009762 ATP binding site [chemical binding]; other site 472759009763 Walker B motif; other site 472759009764 arginine finger; other site 472759009765 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 472759009766 hypothetical protein; Validated; Region: PRK00153 472759009767 recombination protein RecR; Reviewed; Region: recR; PRK00076 472759009768 RecR protein; Region: RecR; pfam02132 472759009769 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 472759009770 putative active site [active] 472759009771 putative metal-binding site [ion binding]; other site 472759009772 tetramer interface [polypeptide binding]; other site 472759009773 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 472759009774 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 472759009775 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 472759009776 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 472759009777 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 472759009778 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 472759009779 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 472759009780 rRNA binding site [nucleotide binding]; other site 472759009781 predicted 30S ribosome binding site; other site 472759009782 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 472759009783 Protein of unknown function (DUF1451); Region: DUF1451; pfam07295 472759009784 Gram-negative porin; Region: Porin_4; pfam13609 472759009785 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 472759009786 nucleoside/Zn binding site; other site 472759009787 dimer interface [polypeptide binding]; other site 472759009788 catalytic motif [active] 472759009789 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 472759009790 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 472759009791 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 472759009792 non-specific DNA binding site [nucleotide binding]; other site 472759009793 salt bridge; other site 472759009794 sequence-specific DNA binding site [nucleotide binding]; other site 472759009795 GMP synthase; Reviewed; Region: guaA; PRK00074 472759009796 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 472759009797 AMP/PPi binding site [chemical binding]; other site 472759009798 candidate oxyanion hole; other site 472759009799 catalytic triad [active] 472759009800 potential glutamine specificity residues [chemical binding]; other site 472759009801 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 472759009802 ATP Binding subdomain [chemical binding]; other site 472759009803 Ligand Binding sites [chemical binding]; other site 472759009804 Dimerization subdomain; other site 472759009805 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 472759009806 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 472759009807 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 472759009808 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 472759009809 active site 472759009810 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 472759009811 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 472759009812 generic binding surface II; other site 472759009813 generic binding surface I; other site 472759009814 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 472759009815 TPR motif; other site 472759009816 binding surface 472759009817 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 472759009818 binding surface 472759009819 TPR motif; other site 472759009820 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 472759009821 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 472759009822 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 472759009823 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 472759009824 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 472759009825 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 472759009826 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 472759009827 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 472759009828 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 472759009829 Rubredoxin [Energy production and conversion]; Region: COG1773 472759009830 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 472759009831 iron binding site [ion binding]; other site 472759009832 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 472759009833 thiamine phosphate binding site [chemical binding]; other site 472759009834 active site 472759009835 pyrophosphate binding site [ion binding]; other site 472759009836 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 472759009837 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 472759009838 catalytic residues [active] 472759009839 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 472759009840 binding surface 472759009841 TPR motif; other site 472759009842 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 472759009843 Mechanosensitive ion channel; Region: MS_channel; pfam00924 472759009844 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 472759009845 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 472759009846 inhibitor-cofactor binding pocket; inhibition site 472759009847 pyridoxal 5'-phosphate binding site [chemical binding]; other site 472759009848 catalytic residue [active] 472759009849 Predicted amidohydrolase [General function prediction only]; Region: COG0388 472759009850 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 472759009851 putative active site [active] 472759009852 catalytic triad [active] 472759009853 putative dimer interface [polypeptide binding]; other site 472759009854 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 472759009855 Part of AAA domain; Region: AAA_19; pfam13245 472759009856 Family description; Region: UvrD_C_2; pfam13538 472759009857 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 472759009858 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 472759009859 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 472759009860 Sel1-like repeats; Region: SEL1; smart00671 472759009861 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 472759009862 Cation efflux family; Region: Cation_efflux; cl00316 472759009863 GYD domain; Region: GYD; cl01743 472759009864 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 472759009865 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 472759009866 active site 472759009867 metal binding site [ion binding]; metal-binding site 472759009868 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 472759009869 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 472759009870 active site residue [active] 472759009871 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 472759009872 active site residue [active] 472759009873 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 472759009874 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 472759009875 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 472759009876 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 472759009877 putative active site [active] 472759009878 Zn binding site [ion binding]; other site 472759009879 PAS domain S-box; Region: sensory_box; TIGR00229 472759009880 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 472759009881 putative active site [active] 472759009882 heme pocket [chemical binding]; other site 472759009883 PAS domain; Region: PAS_9; pfam13426 472759009884 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 472759009885 putative active site [active] 472759009886 heme pocket [chemical binding]; other site 472759009887 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 472759009888 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 472759009889 putative active site [active] 472759009890 heme pocket [chemical binding]; other site 472759009891 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 472759009892 dimer interface [polypeptide binding]; other site 472759009893 phosphorylation site [posttranslational modification] 472759009894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 472759009895 ATP binding site [chemical binding]; other site 472759009896 Mg2+ binding site [ion binding]; other site 472759009897 G-X-G motif; other site 472759009898 Response regulator receiver domain; Region: Response_reg; pfam00072 472759009899 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 472759009900 active site 472759009901 phosphorylation site [posttranslational modification] 472759009902 intermolecular recognition site; other site 472759009903 dimerization interface [polypeptide binding]; other site 472759009904 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 472759009905 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 472759009906 tetramer interface [polypeptide binding]; other site 472759009907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 472759009908 catalytic residue [active] 472759009909 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 472759009910 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 472759009911 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 472759009912 EamA-like transporter family; Region: EamA; pfam00892 472759009913 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 472759009914 classical (c) SDRs; Region: SDR_c; cd05233 472759009915 NAD(P) binding site [chemical binding]; other site 472759009916 active site 472759009917 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 472759009918 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 472759009919 Walker A motif; other site 472759009920 ATP binding site [chemical binding]; other site 472759009921 Walker B motif; other site 472759009922 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 472759009923 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 472759009924 Walker A motif; other site 472759009925 ATP binding site [chemical binding]; other site 472759009926 Walker B motif; other site 472759009927 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 472759009928 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 472759009929 catalytic residue [active] 472759009930 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 472759009931 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 472759009932 YGGT family; Region: YGGT; pfam02325 472759009933 YGGT family; Region: YGGT; pfam02325 472759009934 hypothetical protein; Validated; Region: PRK05090 472759009935 muropeptide transporter; Validated; Region: ampG; cl17669 472759009936 muropeptide transporter; Reviewed; Region: ampG; PRK11902 472759009937 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 472759009938 active site 472759009939 hypothetical protein; Provisional; Region: PRK10621 472759009940 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 472759009941 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 472759009942 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 472759009943 feedback inhibition sensing region; other site 472759009944 homohexameric interface [polypeptide binding]; other site 472759009945 carbamate kinase; Reviewed; Region: PRK12686 472759009946 nucleotide binding site [chemical binding]; other site 472759009947 N-acetyl-L-glutamate binding site [chemical binding]; other site 472759009948 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 472759009949 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 472759009950 active site 472759009951 substrate binding site [chemical binding]; other site 472759009952 metal binding site [ion binding]; metal-binding site 472759009953 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 472759009954 trimer interface [polypeptide binding]; other site 472759009955 active site 472759009956 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 472759009957 Flavoprotein; Region: Flavoprotein; pfam02441 472759009958 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 472759009959 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 472759009960 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 472759009961 putative metal binding site [ion binding]; other site 472759009962 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 472759009963 HSP70 interaction site [polypeptide binding]; other site 472759009964 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 472759009965 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 472759009966 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 472759009967 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759009968 S-adenosylmethionine binding site [chemical binding]; other site 472759009969 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 472759009970 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 472759009971 substrate binding site [chemical binding]; other site 472759009972 active site 472759009973 AIR carboxylase; Region: AIRC; pfam00731 472759009974 DNA topoisomerase I; Provisional; Region: PRK08780 472759009975 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 472759009976 active site 472759009977 interdomain interaction site; other site 472759009978 putative metal-binding site [ion binding]; other site 472759009979 nucleotide binding site [chemical binding]; other site 472759009980 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 472759009981 domain I; other site 472759009982 DNA binding groove [nucleotide binding] 472759009983 phosphate binding site [ion binding]; other site 472759009984 domain II; other site 472759009985 domain III; other site 472759009986 nucleotide binding site [chemical binding]; other site 472759009987 catalytic site [active] 472759009988 domain IV; other site 472759009989 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 472759009990 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 472759009991 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 472759009992 Protein of unknown function (DUF494); Region: DUF494; pfam04361 472759009993 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 472759009994 DNA protecting protein DprA; Region: dprA; TIGR00732 472759009995 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 472759009996 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 472759009997 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 472759009998 active site 472759009999 catalytic residues [active] 472759010000 metal binding site [ion binding]; metal-binding site 472759010001 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 472759010002 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 472759010003 putative active site [active] 472759010004 substrate binding site [chemical binding]; other site 472759010005 putative cosubstrate binding site; other site 472759010006 catalytic site [active] 472759010007 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 472759010008 substrate binding site [chemical binding]; other site 472759010009 16S rRNA methyltransferase B; Provisional; Region: PRK10901 472759010010 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 472759010011 putative RNA binding site [nucleotide binding]; other site 472759010012 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759010013 S-adenosylmethionine binding site [chemical binding]; other site 472759010014 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 472759010015 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 472759010016 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 472759010017 dimerization interface [polypeptide binding]; other site 472759010018 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 472759010019 dimer interface [polypeptide binding]; other site 472759010020 phosphorylation site [posttranslational modification] 472759010021 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 472759010022 ATP binding site [chemical binding]; other site 472759010023 Mg2+ binding site [ion binding]; other site 472759010024 G-X-G motif; other site 472759010025 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 472759010026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 472759010027 active site 472759010028 phosphorylation site [posttranslational modification] 472759010029 intermolecular recognition site; other site 472759010030 dimerization interface [polypeptide binding]; other site 472759010031 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 472759010032 Walker A motif; other site 472759010033 ATP binding site [chemical binding]; other site 472759010034 Walker B motif; other site 472759010035 arginine finger; other site 472759010036 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 472759010037 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 472759010038 TrkA-N domain; Region: TrkA_N; pfam02254 472759010039 TrkA-C domain; Region: TrkA_C; pfam02080 472759010040 TrkA-N domain; Region: TrkA_N; pfam02254 472759010041 TrkA-C domain; Region: TrkA_C; pfam02080 472759010042 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 472759010043 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 472759010044 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 472759010045 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 472759010046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 472759010047 Major Facilitator Superfamily; Region: MFS_1; pfam07690 472759010048 putative substrate translocation pore; other site 472759010049 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 472759010050 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 472759010051 dimer interface [polypeptide binding]; other site 472759010052 ssDNA binding site [nucleotide binding]; other site 472759010053 tetramer (dimer of dimers) interface [polypeptide binding]; other site 472759010054 FRG domain; Region: FRG; pfam08867 472759010055 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 472759010056 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 472759010057 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 472759010058 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 472759010059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304 472759010060 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 472759010061 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 472759010062 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 472759010063 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 472759010064 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 472759010065 binding surface 472759010066 TPR motif; other site 472759010067 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 472759010068 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 472759010069 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 472759010070 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 472759010071 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 472759010072 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 472759010073 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 472759010074 HDOD domain; Region: HDOD; pfam08668 472759010075 Response regulator receiver domain; Region: Response_reg; pfam00072 472759010076 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 472759010077 active site 472759010078 phosphorylation site [posttranslational modification] 472759010079 intermolecular recognition site; other site 472759010080 dimerization interface [polypeptide binding]; other site 472759010081 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 472759010082 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 472759010083 metal binding site [ion binding]; metal-binding site 472759010084 active site 472759010085 I-site; other site 472759010086 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 472759010087 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 472759010088 active site 472759010089 Int/Topo IB signature motif; other site 472759010090 Protein of unknown function, DUF484; Region: DUF484; cl17449 472759010091 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 472759010092 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 472759010093 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 472759010094 Methyltransferase domain; Region: Methyltransf_31; pfam13847 472759010095 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759010096 S-adenosylmethionine binding site [chemical binding]; other site 472759010097 diaminopimelate decarboxylase; Region: lysA; TIGR01048 472759010098 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 472759010099 active site 472759010100 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 472759010101 substrate binding site [chemical binding]; other site 472759010102 catalytic residues [active] 472759010103 dimer interface [polypeptide binding]; other site 472759010104 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 472759010105 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 472759010106 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 472759010107 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 472759010108 Walker A motif; other site 472759010109 ATP binding site [chemical binding]; other site 472759010110 Walker B motif; other site 472759010111 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 472759010112 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 472759010113 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 472759010114 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 472759010115 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 472759010116 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 472759010117 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 472759010118 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 472759010119 CoA-binding site [chemical binding]; other site 472759010120 ATP-binding [chemical binding]; other site 472759010121 hypothetical protein; Provisional; Region: PRK05287 472759010122 Domain of unknown function (DUF329); Region: DUF329; pfam03884 472759010123 hypothetical protein; Provisional; Region: PRK08999 472759010124 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 472759010125 active site 472759010126 8-oxo-dGMP binding site [chemical binding]; other site 472759010127 nudix motif; other site 472759010128 metal binding site [ion binding]; metal-binding site 472759010129 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 472759010130 thiamine phosphate binding site [chemical binding]; other site 472759010131 active site 472759010132 pyrophosphate binding site [ion binding]; other site 472759010133 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 472759010134 Zinc-finger domain; Region: zf-CHCC; cl01821 472759010135 quinolinate synthetase; Provisional; Region: PRK09375 472759010136 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 472759010137 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 472759010138 dimer interface [polypeptide binding]; other site 472759010139 anticodon binding site; other site 472759010140 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 472759010141 homodimer interface [polypeptide binding]; other site 472759010142 motif 1; other site 472759010143 active site 472759010144 motif 2; other site 472759010145 GAD domain; Region: GAD; pfam02938 472759010146 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 472759010147 motif 3; other site 472759010148 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 472759010149 Protein of unknown function (DUF1614); Region: DUF1614; pfam07758 472759010150 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 472759010151 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 472759010152 [2Fe-2S] cluster binding site [ion binding]; other site 472759010153 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 472759010154 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 472759010155 Qi binding site; other site 472759010156 intrachain domain interface; other site 472759010157 interchain domain interface [polypeptide binding]; other site 472759010158 heme bH binding site [chemical binding]; other site 472759010159 heme bL binding site [chemical binding]; other site 472759010160 Qo binding site; other site 472759010161 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 472759010162 interchain domain interface [polypeptide binding]; other site 472759010163 intrachain domain interface; other site 472759010164 Qi binding site; other site 472759010165 Qo binding site; other site 472759010166 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 472759010167 stringent starvation protein A; Provisional; Region: sspA; PRK09481 472759010168 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 472759010169 C-terminal domain interface [polypeptide binding]; other site 472759010170 putative GSH binding site (G-site) [chemical binding]; other site 472759010171 dimer interface [polypeptide binding]; other site 472759010172 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 472759010173 dimer interface [polypeptide binding]; other site 472759010174 N-terminal domain interface [polypeptide binding]; other site 472759010175 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 472759010176 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 472759010177 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 472759010178 substrate binding pocket [chemical binding]; other site 472759010179 membrane-bound complex binding site; other site 472759010180 hinge residues; other site 472759010181 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 472759010182 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 472759010183 Trp docking motif [polypeptide binding]; other site 472759010184 dimer interface [polypeptide binding]; other site 472759010185 active site 472759010186 small subunit binding site [polypeptide binding]; other site 472759010187 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 472759010188 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 472759010189 HIGH motif; other site 472759010190 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 472759010191 active site 472759010192 KMSKS motif; other site 472759010193 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 472759010194 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 472759010195 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 472759010196 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 472759010197 ligand binding site [chemical binding]; other site 472759010198 homodimer interface [polypeptide binding]; other site 472759010199 NAD(P) binding site [chemical binding]; other site 472759010200 trimer interface B [polypeptide binding]; other site 472759010201 trimer interface A [polypeptide binding]; other site 472759010202 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 472759010203 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 472759010204 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 472759010205 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 472759010206 NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078 472759010207 NADP binding site [chemical binding]; other site 472759010208 Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907 472759010209 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 472759010210 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 472759010211 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 472759010212 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 472759010213 NAD(P) binding pocket [chemical binding]; other site 472759010214 Predicted ATP-dependent carboligase related to biotin carboxylase [General function prediction only]; Region: COG2232 472759010215 ATP-grasp domain; Region: ATP-grasp_4; cl17255 472759010216 N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264 472759010217 Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria. It catalyzes the reversible formation of N(5), N...; Region: MCH; cd00545 472759010218 trimer interface I [polypeptide binding]; other site 472759010219 putative substrate binding pocket [chemical binding]; other site 472759010220 trimer interface II [polypeptide binding]; other site 472759010221 ATP-grasp enzyme, GAK system; Region: grasp_GAK; TIGR04356 472759010222 ATP-grasp domain; Region: ATP-grasp_4; cl17255 472759010223 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874 472759010224 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 472759010225 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723 472759010226 hisA/hisF family protein; Region: hisAF_rel; TIGR00734 472759010227 active site 472759010228 ATP-grasp domain; Region: ATP-grasp_4; cl17255 472759010229 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 472759010230 nucleotide binding site [chemical binding]; other site 472759010231 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 472759010232 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 472759010233 chorismate binding enzyme; Region: Chorismate_bind; cl10555 472759010234 AAK_UC: Uncharacterized (UC) amino acid kinase-like proteins found mainly in archaea and a few bacteria. Sequences in this CD are members of the Amino Acid Kinase (AAK) superfamily; Region: AAK_UC; cd04240 472759010235 putative nucleotide binding site [chemical binding]; other site 472759010236 putative substrate binding site [chemical binding]; other site 472759010237 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 472759010238 active site 472759010239 dimer interface [polypeptide binding]; other site 472759010240 metal binding site [ion binding]; metal-binding site 472759010241 shikimate kinase; Reviewed; Region: aroK; PRK00131 472759010242 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 472759010243 ADP binding site [chemical binding]; other site 472759010244 magnesium binding site [ion binding]; other site 472759010245 putative shikimate binding site; other site 472759010246 AMIN domain; Region: AMIN; pfam11741 472759010247 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 472759010248 Secretin and TonB N terminus short domain; Region: STN; smart00965 472759010249 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 472759010250 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 472759010251 Pilus assembly protein, PilP; Region: PilP; pfam04351 472759010252 Pilus assembly protein, PilO; Region: PilO; pfam04350 472759010253 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 472759010254 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 472759010255 Competence protein A; Region: Competence_A; pfam11104 472759010256 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 472759010257 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 472759010258 Transglycosylase; Region: Transgly; pfam00912 472759010259 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 472759010260 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 472759010261 Malic enzyme, N-terminal domain; Region: malic; pfam00390 472759010262 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 472759010263 putative NAD(P) binding site [chemical binding]; other site 472759010264 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 472759010265 Cation transport protein; Region: TrkH; cl17365 472759010266 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 472759010267 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 472759010268 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 472759010269 putative active site [active] 472759010270 catalytic triad [active] 472759010271 putative dimer interface [polypeptide binding]; other site 472759010272 FOG: CBS domain [General function prediction only]; Region: COG0517 472759010273 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 472759010274 Transporter associated domain; Region: CorC_HlyC; smart01091 472759010275 metal-binding heat shock protein; Provisional; Region: PRK00016 472759010276 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 472759010277 PhoH-like protein; Region: PhoH; pfam02562 472759010278 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 472759010279 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 472759010280 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 472759010281 FeS/SAM binding site; other site 472759010282 TRAM domain; Region: TRAM; pfam01938 472759010283 hypothetical protein; Reviewed; Region: PRK00024 472759010284 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 472759010285 MPN+ (JAMM) motif; other site 472759010286 Zinc-binding site [ion binding]; other site 472759010287 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 472759010288 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 472759010289 folate binding site [chemical binding]; other site 472759010290 NADP+ binding site [chemical binding]; other site 472759010291 thymidylate synthase; Reviewed; Region: thyA; PRK01827 472759010292 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 472759010293 dimerization interface [polypeptide binding]; other site 472759010294 active site 472759010295 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 472759010296 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 472759010297 active site 472759010298 NTP binding site [chemical binding]; other site 472759010299 metal binding triad [ion binding]; metal-binding site 472759010300 antibiotic binding site [chemical binding]; other site 472759010301 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 472759010302 YcfA-like protein; Region: YcfA; pfam07927 472759010303 Predicted transcriptional regulator [Transcription]; Region: COG3905 472759010304 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 472759010305 DDE superfamily endonuclease; Region: DDE_3; pfam13358 472759010306 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 472759010307 GTP-binding protein YchF; Reviewed; Region: PRK09601 472759010308 YchF GTPase; Region: YchF; cd01900 472759010309 G1 box; other site 472759010310 GTP/Mg2+ binding site [chemical binding]; other site 472759010311 Switch I region; other site 472759010312 G2 box; other site 472759010313 Switch II region; other site 472759010314 G3 box; other site 472759010315 G4 box; other site 472759010316 G5 box; other site 472759010317 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 472759010318 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 472759010319 putative active site [active] 472759010320 catalytic residue [active] 472759010321 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 472759010322 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 472759010323 5S rRNA interface [nucleotide binding]; other site 472759010324 CTC domain interface [polypeptide binding]; other site 472759010325 L16 interface [polypeptide binding]; other site 472759010326 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 472759010327 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 472759010328 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 472759010329 active site 472759010330 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 472759010331 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 472759010332 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 472759010333 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 472759010334 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 472759010335 binding surface 472759010336 TPR motif; other site 472759010337 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 472759010338 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 472759010339 binding surface 472759010340 TPR motif; other site 472759010341 TPR repeat; Region: TPR_11; pfam13414 472759010342 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 472759010343 binding surface 472759010344 TPR motif; other site 472759010345 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 472759010346 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 472759010347 tRNA; other site 472759010348 putative tRNA binding site [nucleotide binding]; other site 472759010349 putative NADP binding site [chemical binding]; other site 472759010350 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 472759010351 peptide chain release factor 1; Validated; Region: prfA; PRK00591 472759010352 This domain is found in peptide chain release factors; Region: PCRF; smart00937 472759010353 RF-1 domain; Region: RF-1; pfam00472 472759010354 septum formation inhibitor; Reviewed; Region: minC; PRK00339 472759010355 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 472759010356 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 472759010357 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 472759010358 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 472759010359 Switch I; other site 472759010360 Switch II; other site 472759010361 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 472759010362 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 472759010363 HemY protein N-terminus; Region: HemY_N; pfam07219 472759010364 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 472759010365 binding surface 472759010366 TPR motif; other site 472759010367 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 472759010368 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 472759010369 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 472759010370 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 472759010371 active site 472759010372 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 472759010373 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 472759010374 domain interfaces; other site 472759010375 active site 472759010376 argininosuccinate lyase; Provisional; Region: PRK00855 472759010377 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 472759010378 active sites [active] 472759010379 tetramer interface [polypeptide binding]; other site 472759010380 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 472759010381 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 472759010382 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 472759010383 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 472759010384 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 472759010385 protein binding site [polypeptide binding]; other site 472759010386 sucrose synthase; Region: sucr_synth; TIGR02470 472759010387 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 472759010388 putative ADP-binding pocket [chemical binding]; other site 472759010389 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 472759010390 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 472759010391 putative ADP-binding pocket [chemical binding]; other site 472759010392 sucrose phosphate synthase, sucrose phosphatase-like domain, bacterial; Region: sucr_syn_bact_C; TIGR02471 472759010393 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 472759010394 active site 472759010395 motif I; other site 472759010396 motif II; other site 472759010397 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 472759010398 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 472759010399 putative substrate binding site [chemical binding]; other site 472759010400 putative ATP binding site [chemical binding]; other site 472759010401 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 472759010402 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 472759010403 glutaminase active site [active] 472759010404 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 472759010405 dimer interface [polypeptide binding]; other site 472759010406 active site 472759010407 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 472759010408 dimer interface [polypeptide binding]; other site 472759010409 active site 472759010410 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 472759010411 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 472759010412 Substrate binding site; other site 472759010413 Mg++ binding site; other site 472759010414 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 472759010415 active site 472759010416 substrate binding site [chemical binding]; other site 472759010417 CoA binding site [chemical binding]; other site 472759010418 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 472759010419 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 472759010420 gamma subunit interface [polypeptide binding]; other site 472759010421 epsilon subunit interface [polypeptide binding]; other site 472759010422 LBP interface [polypeptide binding]; other site 472759010423 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 472759010424 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 472759010425 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 472759010426 alpha subunit interaction interface [polypeptide binding]; other site 472759010427 Walker A motif; other site 472759010428 ATP binding site [chemical binding]; other site 472759010429 Walker B motif; other site 472759010430 inhibitor binding site; inhibition site 472759010431 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 472759010432 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 472759010433 core domain interface [polypeptide binding]; other site 472759010434 delta subunit interface [polypeptide binding]; other site 472759010435 epsilon subunit interface [polypeptide binding]; other site 472759010436 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 472759010437 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 472759010438 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 472759010439 beta subunit interaction interface [polypeptide binding]; other site 472759010440 Walker A motif; other site 472759010441 ATP binding site [chemical binding]; other site 472759010442 Walker B motif; other site 472759010443 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 472759010444 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 472759010445 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 472759010446 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 472759010447 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 472759010448 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 472759010449 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 472759010450 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 472759010451 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 472759010452 ParB-like nuclease domain; Region: ParBc; pfam02195 472759010453 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 472759010454 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 472759010455 P-loop; other site 472759010456 Magnesium ion binding site [ion binding]; other site 472759010457 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 472759010458 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 472759010459 S-adenosylmethionine binding site [chemical binding]; other site 472759010460 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 472759010461 Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983 472759010462 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 472759010463 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 472759010464 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 472759010465 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 472759010466 trmE is a tRNA modification GTPase; Region: trmE; cd04164 472759010467 G1 box; other site 472759010468 GTP/Mg2+ binding site [chemical binding]; other site 472759010469 Switch I region; other site 472759010470 G2 box; other site 472759010471 Switch II region; other site 472759010472 G3 box; other site 472759010473 G4 box; other site 472759010474 G5 box; other site 472759010475 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 472759010476 membrane protein insertase; Provisional; Region: PRK01318 472759010477 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 472759010478 Ribonuclease P; Region: Ribonuclease_P; cl00457 472759010479 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399