-- dump date 20140619_164435 -- class Genbank::misc_feature -- table misc_feature_note -- id note 153948000001 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 153948000002 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 153948000003 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 153948000004 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 153948000005 active site 153948000006 DNA binding site [nucleotide binding] 153948000007 Int/Topo IB signature motif; other site 153948000008 putative transcriptional regulator MerR; Provisional; Region: PRK13752 153948000009 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 153948000010 DNA binding residues [nucleotide binding] 153948000011 dimer interface [polypeptide binding]; other site 153948000012 mercury binding site [ion binding]; other site 153948000013 putative mercuric transport protein; Provisional; Region: PRK13751 153948000014 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 153948000015 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 153948000016 metal-binding site [ion binding] 153948000017 MerC mercury resistance protein; Region: MerC; cl03934 153948000018 putative mercuric reductase; Provisional; Region: PRK13748 153948000019 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 153948000020 metal-binding site [ion binding] 153948000021 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 153948000022 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 153948000023 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 153948000024 N-acetyl-D-glucosamine binding site [chemical binding]; other site 153948000025 catalytic residue [active] 153948000026 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 153948000027 conjugal transfer protein TrbJ; Provisional; Region: PRK13879 153948000028 conjugal transfer protein TrbI; Provisional; Region: PRK13881 153948000029 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 153948000030 conjugal transfer protein TrbH; Provisional; Region: PRK13883 153948000031 Conjugal transfer protein TrbH; Region: TrbH; pfam07283 153948000032 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 153948000033 VirB7 interaction site; other site 153948000034 VirB8 protein; Region: VirB8; cl01500 153948000035 conjugal transfer protein TrbE; Provisional; Region: PRK13891 153948000036 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 153948000037 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 153948000038 Walker A/P-loop; other site 153948000039 ATP binding site [chemical binding]; other site 153948000040 conjugal transfer protein TrbD; Provisional; Region: PRK13823 153948000041 TrbC/VIRB2 family; Region: TrbC; cl01583 153948000042 Transposase domain (DUF772); Region: DUF772; pfam05598 153948000043 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 153948000044 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 153948000045 conjugal transfer protein TrbA; Provisional; Region: PRK13890 153948000046 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 153948000047 sequence-specific DNA binding site [nucleotide binding]; other site 153948000048 salt bridge; other site 153948000049 ParB-like nuclease domain; Region: ParB; smart00470 153948000050 KorB domain; Region: KorB; pfam08535 153948000051 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 153948000052 putative active site [active] 153948000053 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 153948000054 ParA-like protein; Provisional; Region: PHA02518 153948000055 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 153948000056 P-loop; other site 153948000057 Magnesium ion binding site [ion binding]; other site 153948000058 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 153948000059 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 153948000060 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 153948000061 Walker A motif; other site 153948000062 ATP binding site [chemical binding]; other site 153948000063 Walker B motif; other site 153948000064 arginine finger; other site 153948000065 Uncharacterized conserved protein [Function unknown]; Region: COG2442 153948000066 Transcriptional activator TraM; Region: Activator-TraM; cl11943 153948000067 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 153948000068 P-loop; other site 153948000069 conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877 153948000070 conjugal transfer relaxase TraI; Provisional; Region: PRK13878 153948000071 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 153948000072 conjugal transfer coupling protein TraG; Provisional; Region: PRK13880 153948000073 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 153948000074 Walker A motif; other site 153948000075 ATP binding site [chemical binding]; other site 153948000076 Walker B motif; other site 153948000077 conjugal transfer peptidase TraF; Provisional; Region: PRK13884 153948000078 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 153948000079 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 153948000080 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 153948000081 Protein of unknown function, DUF462; Region: DUF462; cl01190 153948000082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 153948000083 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 153948000084 active site 153948000085 metal binding site [ion binding]; metal-binding site 153948000086 interdomain interaction site; other site 153948000087 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 153948000088 Transposase domain (DUF772); Region: DUF772; pfam05598 153948000089 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 153948000090 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 153948000091 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 153948000092 Switch I region; other site 153948000093 G3 box; other site 153948000094 Switch II region; other site 153948000095 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 153948000096 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 153948000097 active site clefts [active] 153948000098 zinc binding site [ion binding]; other site 153948000099 dimer interface [polypeptide binding]; other site 153948000100 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 153948000101 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 153948000102 Walker A motif; other site 153948000103 ATP binding site [chemical binding]; other site 153948000104 Walker B motif; other site 153948000105 arginine finger; other site 153948000106 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 153948000107 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 153948000108 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 153948000109 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 153948000110 active site 153948000111 motif I; other site 153948000112 motif II; other site 153948000113 putative transposase OrfB; Reviewed; Region: PHA02517 153948000114 HTH-like domain; Region: HTH_21; pfam13276 153948000115 Integrase core domain; Region: rve; pfam00665 153948000116 Integrase core domain; Region: rve_3; cl15866 153948000117 Transposase; Region: HTH_Tnp_1; cl17663 153948000118 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 153948000119 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 153948000120 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 153948000121 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 153948000122 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 153948000123 motif II; other site 153948000124 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 153948000125 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 153948000126 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 153948000127 S-adenosylmethionine binding site [chemical binding]; other site 153948000128 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 153948000129 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 153948000130 HlyD family secretion protein; Region: HlyD_3; pfam13437 153948000131 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 153948000132 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 153948000133 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 153948000134 Transposase domain (DUF772); Region: DUF772; pfam05598 153948000135 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 153948000136 PemK-like protein; Region: PemK; pfam02452 153948000137 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 153948000138 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 153948000139 DnaA N-terminal domain; Region: DnaA_N; pfam11638 153948000140 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 153948000141 Walker A motif; other site 153948000142 ATP binding site [chemical binding]; other site 153948000143 Walker B motif; other site 153948000144 arginine finger; other site 153948000145 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 153948000146 DnaA box-binding interface [nucleotide binding]; other site 153948000147 DNA polymerase III subunit beta; Validated; Region: PRK05643 153948000148 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 153948000149 putative DNA binding surface [nucleotide binding]; other site 153948000150 dimer interface [polypeptide binding]; other site 153948000151 beta-clamp/clamp loader binding surface; other site 153948000152 beta-clamp/translesion DNA polymerase binding surface; other site 153948000153 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 153948000154 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 153948000155 Mg2+ binding site [ion binding]; other site 153948000156 G-X-G motif; other site 153948000157 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 153948000158 anchoring element; other site 153948000159 dimer interface [polypeptide binding]; other site 153948000160 ATP binding site [chemical binding]; other site 153948000161 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 153948000162 active site 153948000163 putative metal-binding site [ion binding]; other site 153948000164 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 153948000165 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 153948000166 putative catalytic site [active] 153948000167 putative metal binding site [ion binding]; other site 153948000168 putative phosphate binding site [ion binding]; other site 153948000169 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 153948000170 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 153948000171 G1 box; other site 153948000172 putative GEF interaction site [polypeptide binding]; other site 153948000173 GTP/Mg2+ binding site [chemical binding]; other site 153948000174 Switch I region; other site 153948000175 G2 box; other site 153948000176 G3 box; other site 153948000177 Switch II region; other site 153948000178 G4 box; other site 153948000179 G5 box; other site 153948000180 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 153948000181 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 153948000182 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 153948000183 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 153948000184 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 153948000185 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 153948000186 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 153948000187 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 153948000188 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 153948000189 DsbD alpha interface [polypeptide binding]; other site 153948000190 catalytic residues [active] 153948000191 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 153948000192 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 153948000193 catalytic residues [active] 153948000194 BON domain; Region: BON; pfam04972 153948000195 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 153948000196 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 153948000197 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 153948000198 Ligand Binding Site [chemical binding]; other site 153948000199 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 153948000200 Predicted metal-binding protein [General function prediction only]; Region: COG3019 153948000201 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 153948000202 Cytochrome c; Region: Cytochrom_C; pfam00034 153948000203 transcriptional regulator PhoU; Provisional; Region: PRK11115 153948000204 PhoU domain; Region: PhoU; pfam01895 153948000205 PhoU domain; Region: PhoU; pfam01895 153948000206 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 153948000207 tetramer (dimer of dimers) interface [polypeptide binding]; other site 153948000208 active site 153948000209 dimer interface [polypeptide binding]; other site 153948000210 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 153948000211 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 153948000212 intersubunit interface [polypeptide binding]; other site 153948000213 active site 153948000214 zinc binding site [ion binding]; other site 153948000215 Na+ binding site [ion binding]; other site 153948000216 pyruvate kinase; Provisional; Region: PRK05826 153948000217 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 153948000218 domain interfaces; other site 153948000219 active site 153948000220 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 153948000221 Phosphoglycerate kinase; Region: PGK; pfam00162 153948000222 substrate binding site [chemical binding]; other site 153948000223 hinge regions; other site 153948000224 ADP binding site [chemical binding]; other site 153948000225 catalytic site [active] 153948000226 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 153948000227 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 153948000228 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 153948000229 transketolase; Reviewed; Region: PRK12753 153948000230 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 153948000231 TPP-binding site [chemical binding]; other site 153948000232 dimer interface [polypeptide binding]; other site 153948000233 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 153948000234 PYR/PP interface [polypeptide binding]; other site 153948000235 dimer interface [polypeptide binding]; other site 153948000236 TPP binding site [chemical binding]; other site 153948000237 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 153948000238 glutamate dehydrogenase; Provisional; Region: PRK09414 153948000239 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 153948000240 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 153948000241 NAD(P) binding site [chemical binding]; other site 153948000242 lytic murein transglycosylase; Provisional; Region: PRK11619 153948000243 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 153948000244 N-acetyl-D-glucosamine binding site [chemical binding]; other site 153948000245 catalytic residue [active] 153948000246 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 153948000247 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 153948000248 active site 153948000249 NTP binding site [chemical binding]; other site 153948000250 metal binding triad [ion binding]; metal-binding site 153948000251 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 153948000252 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 153948000253 Zn2+ binding site [ion binding]; other site 153948000254 Mg2+ binding site [ion binding]; other site 153948000255 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 153948000256 Ion channel; Region: Ion_trans_2; pfam07885 153948000257 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 153948000258 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 153948000259 putative dimer interface [polypeptide binding]; other site 153948000260 ABC transporter ATPase component; Reviewed; Region: PRK11147 153948000261 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 153948000262 Walker A/P-loop; other site 153948000263 ATP binding site [chemical binding]; other site 153948000264 Q-loop/lid; other site 153948000265 ABC transporter signature motif; other site 153948000266 Walker B; other site 153948000267 D-loop; other site 153948000268 H-loop/switch region; other site 153948000269 ABC transporter; Region: ABC_tran_2; pfam12848 153948000270 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 153948000271 Cytochrome c553 [Energy production and conversion]; Region: COG2863 153948000272 Cytochrome c553 [Energy production and conversion]; Region: COG2863 153948000273 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 153948000274 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 153948000275 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 153948000276 minor groove reading motif; other site 153948000277 helix-hairpin-helix signature motif; other site 153948000278 substrate binding pocket [chemical binding]; other site 153948000279 active site 153948000280 ferredoxin; Provisional; Region: PRK08764 153948000281 Putative Fe-S cluster; Region: FeS; pfam04060 153948000282 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 153948000283 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 153948000284 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 153948000285 quinone interaction residues [chemical binding]; other site 153948000286 active site 153948000287 catalytic residues [active] 153948000288 FMN binding site [chemical binding]; other site 153948000289 substrate binding site [chemical binding]; other site 153948000290 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 153948000291 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 153948000292 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 153948000293 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 153948000294 allophanate hydrolase; Provisional; Region: PRK08186 153948000295 Amidase; Region: Amidase; pfam01425 153948000296 urea carboxylase; Region: urea_carbox; TIGR02712 153948000297 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 153948000298 ATP-grasp domain; Region: ATP-grasp_4; cl17255 153948000299 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 153948000300 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 153948000301 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 153948000302 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 153948000303 carboxyltransferase (CT) interaction site; other site 153948000304 biotinylation site [posttranslational modification]; other site 153948000305 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 153948000306 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 153948000307 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 153948000308 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 153948000309 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 153948000310 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 153948000311 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 153948000312 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 153948000313 FG-GAP repeat; Region: FG-GAP; cl15299 153948000314 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 153948000315 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 153948000316 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 153948000317 DNA binding residues [nucleotide binding] 153948000318 dimer interface [polypeptide binding]; other site 153948000319 copper binding site [ion binding]; other site 153948000320 Outer membrane efflux protein; Region: OEP; pfam02321 153948000321 Outer membrane efflux protein; Region: OEP; pfam02321 153948000322 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 153948000323 HlyD family secretion protein; Region: HlyD_3; pfam13437 153948000324 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 153948000325 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 153948000326 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 153948000327 catalytic triad [active] 153948000328 putative active site [active] 153948000329 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 153948000330 Kelch domain; Region: Kelch; smart00612 153948000331 Kelch motif; Region: Kelch_1; pfam01344 153948000332 Galactose oxidase, central domain; Region: Kelch_3; cl02701 153948000333 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 153948000334 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 153948000335 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 153948000336 AAA ATPase domain; Region: AAA_16; pfam13191 153948000337 Walker A motif; other site 153948000338 ATP binding site [chemical binding]; other site 153948000339 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 153948000340 HsdM N-terminal domain; Region: HsdM_N; pfam12161 153948000341 Methyltransferase domain; Region: Methyltransf_26; pfam13659 153948000342 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 153948000343 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 153948000344 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 153948000345 ATP binding site [chemical binding]; other site 153948000346 putative Mg++ binding site [ion binding]; other site 153948000347 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 153948000348 S-adenosylmethionine binding site [chemical binding]; other site 153948000349 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 153948000350 endonuclease III; Region: ENDO3c; smart00478 153948000351 minor groove reading motif; other site 153948000352 helix-hairpin-helix signature motif; other site 153948000353 substrate binding pocket [chemical binding]; other site 153948000354 active site 153948000355 cell division protein MraZ; Reviewed; Region: PRK00326 153948000356 MraZ protein; Region: MraZ; pfam02381 153948000357 MraZ protein; Region: MraZ; pfam02381 153948000358 MraW methylase family; Region: Methyltransf_5; cl17771 153948000359 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 153948000360 Cell division protein FtsL; Region: FtsL; pfam04999 153948000361 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 153948000362 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 153948000363 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 153948000364 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 153948000365 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 153948000366 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 153948000367 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 153948000368 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 153948000369 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 153948000370 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 153948000371 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 153948000372 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 153948000373 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 153948000374 Mg++ binding site [ion binding]; other site 153948000375 putative catalytic motif [active] 153948000376 putative substrate binding site [chemical binding]; other site 153948000377 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006 153948000378 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 153948000379 NAD(P) binding pocket [chemical binding]; other site 153948000380 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 153948000381 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 153948000382 cell division protein FtsW; Region: ftsW; TIGR02614 153948000383 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 153948000384 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 153948000385 active site 153948000386 homodimer interface [polypeptide binding]; other site 153948000387 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 153948000388 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 153948000389 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 153948000390 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 153948000391 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 153948000392 FAD binding domain; Region: FAD_binding_4; pfam01565 153948000393 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 153948000394 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 153948000395 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 153948000396 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 153948000397 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 153948000398 Cell division protein FtsQ; Region: FtsQ; pfam03799 153948000399 cell division protein FtsA; Region: ftsA; TIGR01174 153948000400 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 153948000401 nucleotide binding site [chemical binding]; other site 153948000402 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 153948000403 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 153948000404 Cell division protein FtsA; Region: FtsA; pfam14450 153948000405 cell division protein FtsZ; Validated; Region: PRK09330 153948000406 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 153948000407 nucleotide binding site [chemical binding]; other site 153948000408 SulA interaction site; other site 153948000409 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 153948000410 PAS fold; Region: PAS_3; pfam08447 153948000411 putative active site [active] 153948000412 heme pocket [chemical binding]; other site 153948000413 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 153948000414 dimerization interface [polypeptide binding]; other site 153948000415 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 153948000416 dimer interface [polypeptide binding]; other site 153948000417 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 153948000418 putative CheW interface [polypeptide binding]; other site 153948000419 Transposase domain (DUF772); Region: DUF772; pfam05598 153948000420 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 153948000421 AAA domain; Region: AAA_11; pfam13086 153948000422 Part of AAA domain; Region: AAA_19; pfam13245 153948000423 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 153948000424 AAA domain; Region: AAA_12; pfam13087 153948000425 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 153948000426 putative active site [active] 153948000427 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023 153948000428 active site 153948000429 metal-binding site 153948000430 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 153948000431 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 153948000432 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 153948000433 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 153948000434 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 153948000435 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 153948000436 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 153948000437 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 153948000438 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 153948000439 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 153948000440 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 153948000441 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 153948000442 Lipopolysaccharide-assembly; Region: LptE; cl01125 153948000443 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 153948000444 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 153948000445 HIGH motif; other site 153948000446 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 153948000447 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 153948000448 active site 153948000449 KMSKS motif; other site 153948000450 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 153948000451 tRNA binding surface [nucleotide binding]; other site 153948000452 Dodecin; Region: Dodecin; pfam07311 153948000453 Peptidase family M48; Region: Peptidase_M48; pfam01435 153948000454 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 153948000455 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 153948000456 dimer interface [polypeptide binding]; other site 153948000457 putative metal binding site [ion binding]; other site 153948000458 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 153948000459 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 153948000460 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 153948000461 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 153948000462 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 153948000463 dimerization interface [polypeptide binding]; other site 153948000464 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 153948000465 dimer interface [polypeptide binding]; other site 153948000466 putative CheW interface [polypeptide binding]; other site 153948000467 rare lipoprotein A; Region: rlpA; TIGR00413 153948000468 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 153948000469 Sporulation related domain; Region: SPOR; pfam05036 153948000470 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 153948000471 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 153948000472 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 153948000473 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 153948000474 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 153948000475 rod shape-determining protein MreC; Provisional; Region: PRK13922 153948000476 rod shape-determining protein MreC; Region: MreC; pfam04085 153948000477 rod shape-determining protein MreB; Provisional; Region: PRK13927 153948000478 MreB and similar proteins; Region: MreB_like; cd10225 153948000479 nucleotide binding site [chemical binding]; other site 153948000480 Mg binding site [ion binding]; other site 153948000481 putative protofilament interaction site [polypeptide binding]; other site 153948000482 RodZ interaction site [polypeptide binding]; other site 153948000483 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 153948000484 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 153948000485 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 153948000486 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 153948000487 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 153948000488 GatB domain; Region: GatB_Yqey; smart00845 153948000489 Protein of unknown function, DUF393; Region: DUF393; pfam04134 153948000490 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 153948000491 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 153948000492 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 153948000493 Putative glucoamylase; Region: Glycoamylase; pfam10091 153948000494 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 153948000495 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 153948000496 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 153948000497 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 153948000498 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 153948000499 Uncharacterized conserved protein [Function unknown]; Region: COG3391 153948000500 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 153948000501 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 153948000502 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948000503 active site 153948000504 phosphorylation site [posttranslational modification] 153948000505 intermolecular recognition site; other site 153948000506 dimerization interface [polypeptide binding]; other site 153948000507 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 153948000508 DNA binding residues [nucleotide binding] 153948000509 dimerization interface [polypeptide binding]; other site 153948000510 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 153948000511 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 153948000512 active site 153948000513 dimerization interface [polypeptide binding]; other site 153948000514 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 153948000515 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 153948000516 Protein of unknown function (DUF466); Region: DUF466; pfam04328 153948000517 carbon starvation protein A; Provisional; Region: PRK15015 153948000518 Carbon starvation protein CstA; Region: CstA; pfam02554 153948000519 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 153948000520 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 153948000521 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 153948000522 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 153948000523 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 153948000524 active site 153948000525 HIGH motif; other site 153948000526 dimer interface [polypeptide binding]; other site 153948000527 KMSKS motif; other site 153948000528 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 153948000529 Peptidase family M50; Region: Peptidase_M50; pfam02163 153948000530 active site 153948000531 putative substrate binding region [chemical binding]; other site 153948000532 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 153948000533 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 153948000534 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 153948000535 active site 153948000536 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 153948000537 NnrS protein; Region: NnrS; pfam05940 153948000538 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 153948000539 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 153948000540 homodimer interface [polypeptide binding]; other site 153948000541 pyridoxal 5'-phosphate binding site [chemical binding]; other site 153948000542 catalytic residue [active] 153948000543 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 153948000544 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 153948000545 Mg++ binding site [ion binding]; other site 153948000546 putative catalytic motif [active] 153948000547 putative substrate binding site [chemical binding]; other site 153948000548 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 153948000549 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 153948000550 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 153948000551 NAD(P) binding site [chemical binding]; other site 153948000552 homodimer interface [polypeptide binding]; other site 153948000553 substrate binding site [chemical binding]; other site 153948000554 active site 153948000555 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 153948000556 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 153948000557 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 153948000558 Walker A/P-loop; other site 153948000559 ATP binding site [chemical binding]; other site 153948000560 Q-loop/lid; other site 153948000561 ABC transporter signature motif; other site 153948000562 Walker B; other site 153948000563 D-loop; other site 153948000564 H-loop/switch region; other site 153948000565 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 153948000566 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 153948000567 substrate binding site; other site 153948000568 tetramer interface; other site 153948000569 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 153948000570 DNA repair protein RadA; Provisional; Region: PRK11823 153948000571 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 153948000572 Walker A motif/ATP binding site; other site 153948000573 ATP binding site [chemical binding]; other site 153948000574 Walker B motif; other site 153948000575 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 153948000576 acyl-CoA synthetase; Validated; Region: PRK09192 153948000577 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 153948000578 acyl-activating enzyme (AAE) consensus motif; other site 153948000579 active site 153948000580 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 153948000581 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 153948000582 NAD(P) binding site [chemical binding]; other site 153948000583 active site 153948000584 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 153948000585 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 153948000586 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 153948000587 substrate-cofactor binding pocket; other site 153948000588 pyridoxal 5'-phosphate binding site [chemical binding]; other site 153948000589 catalytic residue [active] 153948000590 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 153948000591 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 153948000592 putative active site [active] 153948000593 PhoH-like protein; Region: PhoH; pfam02562 153948000594 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 153948000595 Helix-turn-helix domain; Region: HTH_38; pfam13936 153948000596 Homeodomain-like domain; Region: HTH_32; pfam13565 153948000597 Integrase core domain; Region: rve; pfam00665 153948000598 Transposase; Region: HTH_Tnp_1; cl17663 153948000599 putative transposase OrfB; Reviewed; Region: PHA02517 153948000600 HTH-like domain; Region: HTH_21; pfam13276 153948000601 Integrase core domain; Region: rve; pfam00665 153948000602 Integrase core domain; Region: rve_3; cl15866 153948000603 Transposase; Region: DEDD_Tnp_IS110; pfam01548 153948000604 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 153948000605 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 153948000606 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 153948000607 Integrase core domain; Region: rve; pfam00665 153948000608 transposase/IS protein; Provisional; Region: PRK09183 153948000609 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 153948000610 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 153948000611 Walker A/P-loop; other site 153948000612 ATP binding site [chemical binding]; other site 153948000613 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 153948000614 Q-loop/lid; other site 153948000615 ABC transporter signature motif; other site 153948000616 Walker B; other site 153948000617 D-loop; other site 153948000618 H-loop/switch region; other site 153948000619 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 153948000620 active site 153948000621 metal binding site [ion binding]; metal-binding site 153948000622 Replication initiation factor; Region: Rep_trans; pfam02486 153948000623 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 153948000624 Int/Topo IB signature motif; other site 153948000625 Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]; Region: GrxC; COG0695 153948000626 DoxX; Region: DoxX; pfam07681 153948000627 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 153948000628 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 153948000629 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 153948000630 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 153948000631 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 153948000632 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 153948000633 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 153948000634 multiple promoter invertase; Provisional; Region: mpi; PRK13413 153948000635 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 153948000636 catalytic residues [active] 153948000637 catalytic nucleophile [active] 153948000638 Presynaptic Site I dimer interface [polypeptide binding]; other site 153948000639 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 153948000640 Synaptic Flat tetramer interface [polypeptide binding]; other site 153948000641 Synaptic Site I dimer interface [polypeptide binding]; other site 153948000642 DNA binding site [nucleotide binding] 153948000643 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 153948000644 DNA-binding interface [nucleotide binding]; DNA binding site 153948000645 Antirestriction protein (ArdA); Region: ArdA; cl01953 153948000646 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 153948000647 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 153948000648 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 153948000649 Transposase domain (DUF772); Region: DUF772; pfam05598 153948000650 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 153948000651 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 153948000652 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 153948000653 AAA domain; Region: AAA_23; pfam13476 153948000654 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 153948000655 Walker A/P-loop; other site 153948000656 ATP binding site [chemical binding]; other site 153948000657 Transposase domain (DUF772); Region: DUF772; pfam05598 153948000658 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 153948000659 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 153948000660 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 153948000661 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 153948000662 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 153948000663 Walker A motif; other site 153948000664 ATP binding site [chemical binding]; other site 153948000665 Walker B motif; other site 153948000666 Sel1-like repeats; Region: SEL1; smart00671 153948000667 Sel1-like repeats; Region: SEL1; smart00671 153948000668 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 153948000669 binding surface 153948000670 TPR repeat; Region: TPR_11; pfam13414 153948000671 TPR motif; other site 153948000672 TPR repeat; Region: TPR_11; pfam13414 153948000673 Sel1-like repeats; Region: SEL1; smart00671 153948000674 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 153948000675 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 153948000676 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 153948000677 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 153948000678 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 153948000679 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 153948000680 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 153948000681 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 153948000682 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 153948000683 catalytic residues [active] 153948000684 catalytic nucleophile [active] 153948000685 Recombinase; Region: Recombinase; pfam07508 153948000686 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 153948000687 transposase/IS protein; Provisional; Region: PRK09183 153948000688 Putative ATP-dependent Lon protease; Region: Lon_2; cl11979 153948000689 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 153948000690 Walker A motif; other site 153948000691 ATP binding site [chemical binding]; other site 153948000692 Walker B motif; other site 153948000693 arginine finger; other site 153948000694 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 153948000695 Helix-turn-helix domain; Region: HTH_38; pfam13936 153948000696 Integrase core domain; Region: rve; pfam00665 153948000697 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 153948000698 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 153948000699 salt bridge; other site 153948000700 non-specific DNA binding site [nucleotide binding]; other site 153948000701 sequence-specific DNA binding site [nucleotide binding]; other site 153948000702 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 153948000703 Protein of unknown function (DUF497); Region: DUF497; pfam04365 153948000704 Helix-turn-helix domain; Region: HTH_17; pfam12728 153948000705 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 153948000706 Transposase, Mutator family; Region: Transposase_mut; pfam00872 153948000707 MULE transposase domain; Region: MULE; pfam10551 153948000708 Dehydroquinase class II; Region: DHquinase_II; pfam01220 153948000709 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 153948000710 trimer interface [polypeptide binding]; other site 153948000711 active site 153948000712 dimer interface [polypeptide binding]; other site 153948000713 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 153948000714 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 153948000715 carboxyltransferase (CT) interaction site; other site 153948000716 biotinylation site [posttranslational modification]; other site 153948000717 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 153948000718 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 153948000719 ATP-grasp domain; Region: ATP-grasp_4; cl17255 153948000720 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 153948000721 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 153948000722 DNA methylase; Region: N6_N4_Mtase; cl17433 153948000723 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 153948000724 S-adenosylmethionine binding site [chemical binding]; other site 153948000725 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 153948000726 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 153948000727 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 153948000728 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 153948000729 P loop; other site 153948000730 Nucleotide binding site [chemical binding]; other site 153948000731 DTAP/Switch II; other site 153948000732 Switch I; other site 153948000733 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 153948000734 P loop; other site 153948000735 Nucleotide binding site [chemical binding]; other site 153948000736 DTAP/Switch II; other site 153948000737 Switch I; other site 153948000738 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 153948000739 arsenical pump membrane protein; Provisional; Region: PRK15445 153948000740 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 153948000741 transmembrane helices; other site 153948000742 Low molecular weight phosphatase family; Region: LMWPc; cd00115 153948000743 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 153948000744 active site 153948000745 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 153948000746 putative metal binding site [ion binding]; other site 153948000747 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 153948000748 putative DNA binding site [nucleotide binding]; other site 153948000749 putative Zn2+ binding site [ion binding]; other site 153948000750 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 153948000751 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 153948000752 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 153948000753 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 153948000754 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 153948000755 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 153948000756 active site 153948000757 nucleophile elbow; other site 153948000758 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 153948000759 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 153948000760 putative active site [active] 153948000761 putative metal binding site [ion binding]; other site 153948000762 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 153948000763 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 153948000764 Serine hydrolase; Region: Ser_hydrolase; cl17834 153948000765 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 153948000766 active site 153948000767 catalytic triad [active] 153948000768 oxyanion hole [active] 153948000769 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 153948000770 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 153948000771 active site 153948000772 homodimer interface [polypeptide binding]; other site 153948000773 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 153948000774 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 153948000775 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 153948000776 FeS/SAM binding site; other site 153948000777 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 153948000778 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 153948000779 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 153948000780 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 153948000781 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 153948000782 putative acyl-acceptor binding pocket; other site 153948000783 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 153948000784 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 153948000785 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 153948000786 substrate binding pocket [chemical binding]; other site 153948000787 membrane-bound complex binding site; other site 153948000788 hinge residues; other site 153948000789 HemK family putative methylases; Region: hemK_fam; TIGR00536 153948000790 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 153948000791 S-adenosylmethionine binding site [chemical binding]; other site 153948000792 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 153948000793 nucleoside/Zn binding site; other site 153948000794 dimer interface [polypeptide binding]; other site 153948000795 catalytic motif [active] 153948000796 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 153948000797 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 153948000798 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 153948000799 FecR protein; Region: FecR; pfam04773 153948000800 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 153948000801 CHASE2 domain; Region: CHASE2; pfam05226 153948000802 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001 153948000803 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 153948000804 putative active site [active] 153948000805 heme pocket [chemical binding]; other site 153948000806 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 153948000807 metal binding site [ion binding]; metal-binding site 153948000808 active site 153948000809 I-site; other site 153948000810 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 153948000811 threonine dehydratase; Reviewed; Region: PRK09224 153948000812 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 153948000813 tetramer interface [polypeptide binding]; other site 153948000814 pyridoxal 5'-phosphate binding site [chemical binding]; other site 153948000815 catalytic residue [active] 153948000816 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 153948000817 putative Ile/Val binding site [chemical binding]; other site 153948000818 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 153948000819 putative Ile/Val binding site [chemical binding]; other site 153948000820 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 153948000821 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 153948000822 dimer interface [polypeptide binding]; other site 153948000823 putative CheW interface [polypeptide binding]; other site 153948000824 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 153948000825 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 153948000826 putative binding surface; other site 153948000827 active site 153948000828 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 153948000829 putative binding surface; other site 153948000830 active site 153948000831 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 153948000832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 153948000833 ATP binding site [chemical binding]; other site 153948000834 Mg2+ binding site [ion binding]; other site 153948000835 G-X-G motif; other site 153948000836 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 153948000837 Response regulator receiver domain; Region: Response_reg; pfam00072 153948000838 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948000839 active site 153948000840 phosphorylation site [posttranslational modification] 153948000841 intermolecular recognition site; other site 153948000842 dimerization interface [polypeptide binding]; other site 153948000843 Dihydroneopterin aldolase; Region: FolB; smart00905 153948000844 active site 153948000845 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 153948000846 UGMP family protein; Validated; Region: PRK09604 153948000847 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 153948000848 Fumble; Region: Fumble; cl17357 153948000849 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 153948000850 malate--CoA ligase subunit beta; Provisional; Region: PRK14046 153948000851 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 153948000852 CoA-ligase; Region: Ligase_CoA; pfam00549 153948000853 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 153948000854 CoA binding domain; Region: CoA_binding; smart00881 153948000855 CoA-ligase; Region: Ligase_CoA; pfam00549 153948000856 Hemerythrin-like domain; Region: Hr-like; cd12108 153948000857 Fe binding site [ion binding]; other site 153948000858 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 153948000859 hypothetical protein; Provisional; Region: PRK05208 153948000860 Calx-beta domain; Region: Calx-beta; cl02522 153948000861 Calx-beta domain; Region: Calx-beta; cl02522 153948000862 Calx-beta domain; Region: Calx-beta; cl02522 153948000863 Calx-beta domain; Region: Calx-beta; pfam03160 153948000864 Calx-beta domain; Region: Calx-beta; cl02522 153948000865 Calx-beta domain; Region: Calx-beta; cl02522 153948000866 Calx-beta domain; Region: Calx-beta; pfam03160 153948000867 Competence-damaged protein; Region: CinA; pfam02464 153948000868 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 153948000869 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 153948000870 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 153948000871 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 153948000872 HsdM N-terminal domain; Region: HsdM_N; pfam12161 153948000873 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 153948000874 S-adenosylmethionine binding site [chemical binding]; other site 153948000875 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 153948000876 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 153948000877 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 153948000878 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 153948000879 oligomeric interface; other site 153948000880 putative active site [active] 153948000881 homodimer interface [polypeptide binding]; other site 153948000882 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 153948000883 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 153948000884 GIY-YIG motif/motif A; other site 153948000885 putative active site [active] 153948000886 putative metal binding site [ion binding]; other site 153948000887 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 153948000888 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 153948000889 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 153948000890 ATP binding site [chemical binding]; other site 153948000891 putative Mg++ binding site [ion binding]; other site 153948000892 putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073 153948000893 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 153948000894 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 153948000895 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 153948000896 substrate binding pocket [chemical binding]; other site 153948000897 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 153948000898 B12 binding site [chemical binding]; other site 153948000899 cobalt ligand [ion binding]; other site 153948000900 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 153948000901 hypothetical protein; Provisional; Region: PRK05287 153948000902 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 153948000903 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 153948000904 CoA-binding site [chemical binding]; other site 153948000905 ATP-binding [chemical binding]; other site 153948000906 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 153948000907 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 153948000908 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 153948000909 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 153948000910 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 153948000911 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 153948000912 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 153948000913 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 153948000914 putative NAD(P) binding site [chemical binding]; other site 153948000915 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 153948000916 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 153948000917 catalytic loop [active] 153948000918 iron binding site [ion binding]; other site 153948000919 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 153948000920 FAD binding pocket [chemical binding]; other site 153948000921 FAD binding motif [chemical binding]; other site 153948000922 phosphate binding motif [ion binding]; other site 153948000923 beta-alpha-beta structure motif; other site 153948000924 NAD binding pocket [chemical binding]; other site 153948000925 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 153948000926 HemY protein N-terminus; Region: HemY_N; pfam07219 153948000927 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 153948000928 binding surface 153948000929 TPR motif; other site 153948000930 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 153948000931 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 153948000932 active site 153948000933 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 153948000934 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 153948000935 domain interfaces; other site 153948000936 active site 153948000937 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 153948000938 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 153948000939 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 153948000940 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 153948000941 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 153948000942 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 153948000943 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 153948000944 S-adenosylmethionine binding site [chemical binding]; other site 153948000945 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 153948000946 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 153948000947 active site 153948000948 (T/H)XGH motif; other site 153948000949 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 153948000950 HDOD domain; Region: HDOD; pfam08668 153948000951 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 153948000952 Zn2+ binding site [ion binding]; other site 153948000953 Mg2+ binding site [ion binding]; other site 153948000954 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 153948000955 EAL domain; Region: EAL; pfam00563 153948000956 cyanophycin synthetase; Provisional; Region: PRK14016 153948000957 ATP-grasp domain; Region: ATP-grasp_4; cl17255 153948000958 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 153948000959 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 153948000960 cyanophycin synthetase; Provisional; Region: PRK14016 153948000961 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 153948000962 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 153948000963 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 153948000964 Domain of unknown function DUF21; Region: DUF21; pfam01595 153948000965 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 153948000966 Transporter associated domain; Region: CorC_HlyC; smart01091 153948000967 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 153948000968 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 153948000969 putative substrate binding site [chemical binding]; other site 153948000970 putative ATP binding site [chemical binding]; other site 153948000971 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 153948000972 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 153948000973 putative ADP-binding pocket [chemical binding]; other site 153948000974 sucrose phosphate synthase, sucrose phosphatase-like domain, bacterial; Region: sucr_syn_bact_C; TIGR02471 153948000975 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 153948000976 trehalose synthase; Region: treS_nterm; TIGR02456 153948000977 active site 153948000978 catalytic site [active] 153948000979 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 153948000980 Lumazine binding domain; Region: Lum_binding; pfam00677 153948000981 Lumazine binding domain; Region: Lum_binding; pfam00677 153948000982 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 153948000983 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 153948000984 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 153948000985 dimerization interface [polypeptide binding]; other site 153948000986 active site 153948000987 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 153948000988 homopentamer interface [polypeptide binding]; other site 153948000989 active site 153948000990 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 153948000991 putative RNA binding site [nucleotide binding]; other site 153948000992 thiamine monophosphate kinase; Provisional; Region: PRK05731 153948000993 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 153948000994 ATP binding site [chemical binding]; other site 153948000995 dimerization interface [polypeptide binding]; other site 153948000996 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 153948000997 tetramer interfaces [polypeptide binding]; other site 153948000998 binuclear metal-binding site [ion binding]; other site 153948000999 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 153948001000 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 153948001001 transmembrane helices; other site 153948001002 SnoaL-like domain; Region: SnoaL_2; pfam12680 153948001003 hypothetical protein; Validated; Region: PRK02101 153948001004 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 153948001005 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 153948001006 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 153948001007 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 153948001008 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 153948001009 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 153948001010 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 153948001011 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 153948001012 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 153948001013 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 153948001014 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 153948001015 Flagellar FliJ protein; Region: FliJ; pfam02050 153948001016 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 153948001017 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 153948001018 Walker A motif/ATP binding site; other site 153948001019 Walker B motif; other site 153948001020 flagellar assembly protein H; Validated; Region: fliH; PRK05687 153948001021 Flagellar assembly protein FliH; Region: FliH; pfam02108 153948001022 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 153948001023 FliG C-terminal domain; Region: FliG_C; pfam01706 153948001024 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 153948001025 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 153948001026 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 153948001027 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 153948001028 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 153948001029 dimer interface [polypeptide binding]; other site 153948001030 phosphorylation site [posttranslational modification] 153948001031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 153948001032 ATP binding site [chemical binding]; other site 153948001033 Mg2+ binding site [ion binding]; other site 153948001034 G-X-G motif; other site 153948001035 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 153948001036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948001037 active site 153948001038 phosphorylation site [posttranslational modification] 153948001039 intermolecular recognition site; other site 153948001040 dimerization interface [polypeptide binding]; other site 153948001041 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 153948001042 Walker A motif; other site 153948001043 ATP binding site [chemical binding]; other site 153948001044 Walker B motif; other site 153948001045 arginine finger; other site 153948001046 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 153948001047 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 153948001048 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 153948001049 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 153948001050 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 153948001051 ABC transporter; Region: ABC_tran_2; pfam12848 153948001052 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 153948001053 Transposase domain (DUF772); Region: DUF772; pfam05598 153948001054 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 153948001055 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 153948001056 Transposase domain (DUF772); Region: DUF772; pfam05598 153948001057 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 153948001058 S-adenosylmethionine binding site [chemical binding]; other site 153948001059 MgtC family; Region: MgtC; pfam02308 153948001060 Predicted membrane protein [Function unknown]; Region: COG3174 153948001061 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 153948001062 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 153948001063 DHH family; Region: DHH; pfam01368 153948001064 DHHA1 domain; Region: DHHA1; pfam02272 153948001065 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 153948001066 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 153948001067 Transporter associated domain; Region: CorC_HlyC; smart01091 153948001068 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 153948001069 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 153948001070 PhoH-like protein; Region: PhoH; pfam02562 153948001071 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 153948001072 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 153948001073 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 153948001074 FeS/SAM binding site; other site 153948001075 TRAM domain; Region: TRAM; pfam01938 153948001076 beta-ketothiolase; Provisional; Region: PRK09051 153948001077 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 153948001078 dimer interface [polypeptide binding]; other site 153948001079 active site 153948001080 ATP synthase I chain; Region: ATP_synt_I; cl09170 153948001081 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 153948001082 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 153948001083 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 153948001084 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 153948001085 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 153948001086 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 153948001087 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 153948001088 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 153948001089 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 153948001090 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 153948001091 beta subunit interaction interface [polypeptide binding]; other site 153948001092 Walker A motif; other site 153948001093 ATP binding site [chemical binding]; other site 153948001094 Walker B motif; other site 153948001095 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 153948001096 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 153948001097 core domain interface [polypeptide binding]; other site 153948001098 delta subunit interface [polypeptide binding]; other site 153948001099 epsilon subunit interface [polypeptide binding]; other site 153948001100 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 153948001101 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 153948001102 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 153948001103 alpha subunit interaction interface [polypeptide binding]; other site 153948001104 Walker A motif; other site 153948001105 ATP binding site [chemical binding]; other site 153948001106 Walker B motif; other site 153948001107 inhibitor binding site; inhibition site 153948001108 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 153948001109 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 153948001110 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 153948001111 gamma subunit interface [polypeptide binding]; other site 153948001112 epsilon subunit interface [polypeptide binding]; other site 153948001113 LBP interface [polypeptide binding]; other site 153948001114 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 153948001115 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 153948001116 Substrate binding site; other site 153948001117 Mg++ binding site; other site 153948001118 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 153948001119 active site 153948001120 substrate binding site [chemical binding]; other site 153948001121 CoA binding site [chemical binding]; other site 153948001122 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 153948001123 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 153948001124 glutaminase active site [active] 153948001125 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 153948001126 dimer interface [polypeptide binding]; other site 153948001127 active site 153948001128 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 153948001129 dimer interface [polypeptide binding]; other site 153948001130 active site 153948001131 hypothetical protein; Validated; Region: PRK00110 153948001132 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 153948001133 active site 153948001134 putative DNA-binding cleft [nucleotide binding]; other site 153948001135 dimer interface [polypeptide binding]; other site 153948001136 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 153948001137 RuvA N terminal domain; Region: RuvA_N; pfam01330 153948001138 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 153948001139 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 153948001140 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 153948001141 Walker A motif; other site 153948001142 ATP binding site [chemical binding]; other site 153948001143 Walker B motif; other site 153948001144 arginine finger; other site 153948001145 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 153948001146 YccA-like proteins; Region: YccA_like; cd10433 153948001147 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 153948001148 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 153948001149 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 153948001150 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 153948001151 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 153948001152 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 153948001153 Subunit I/III interface [polypeptide binding]; other site 153948001154 D-pathway; other site 153948001155 Subunit I/VIIc interface [polypeptide binding]; other site 153948001156 Subunit I/IV interface [polypeptide binding]; other site 153948001157 Subunit I/II interface [polypeptide binding]; other site 153948001158 Low-spin heme (heme a) binding site [chemical binding]; other site 153948001159 Subunit I/VIIa interface [polypeptide binding]; other site 153948001160 Subunit I/VIa interface [polypeptide binding]; other site 153948001161 Dimer interface; other site 153948001162 Putative water exit pathway; other site 153948001163 Binuclear center (heme a3/CuB) [ion binding]; other site 153948001164 K-pathway; other site 153948001165 Subunit I/Vb interface [polypeptide binding]; other site 153948001166 Putative proton exit pathway; other site 153948001167 Subunit I/VIb interface; other site 153948001168 Subunit I/VIc interface [polypeptide binding]; other site 153948001169 Electron transfer pathway; other site 153948001170 Subunit I/VIIIb interface [polypeptide binding]; other site 153948001171 Subunit I/VIIb interface [polypeptide binding]; other site 153948001172 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 153948001173 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 153948001174 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 153948001175 Subunit III/VIIa interface [polypeptide binding]; other site 153948001176 Phospholipid binding site [chemical binding]; other site 153948001177 Subunit I/III interface [polypeptide binding]; other site 153948001178 Subunit III/VIb interface [polypeptide binding]; other site 153948001179 Subunit III/VIa interface; other site 153948001180 Subunit III/Vb interface [polypeptide binding]; other site 153948001181 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 153948001182 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 153948001183 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 153948001184 UbiA prenyltransferase family; Region: UbiA; pfam01040 153948001185 FAD binding domain; Region: FAD_binding_4; pfam01565 153948001186 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 153948001187 outer membrane lipoprotein; Provisional; Region: PRK11023 153948001188 BON domain; Region: BON; pfam04972 153948001189 BON domain; Region: BON; pfam04972 153948001190 CheW-like domain; Region: CheW; pfam01584 153948001191 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 153948001192 feedback inhibition sensing region; other site 153948001193 homohexameric interface [polypeptide binding]; other site 153948001194 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 153948001195 nucleotide binding site [chemical binding]; other site 153948001196 N-acetyl-L-glutamate binding site [chemical binding]; other site 153948001197 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 153948001198 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 153948001199 Cytochrome c; Region: Cytochrom_C; pfam00034 153948001200 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 153948001201 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 153948001202 D-pathway; other site 153948001203 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 153948001204 Binuclear center (active site) [active] 153948001205 K-pathway; other site 153948001206 Putative proton exit pathway; other site 153948001207 MoxR-like ATPases [General function prediction only]; Region: COG0714 153948001208 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 153948001209 Walker A motif; other site 153948001210 ATP binding site [chemical binding]; other site 153948001211 Walker B motif; other site 153948001212 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 153948001213 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 153948001214 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 153948001215 metal ion-dependent adhesion site (MIDAS); other site 153948001216 DNA methylase; Region: N6_N4_Mtase; cl17433 153948001217 DNA methylase; Region: N6_N4_Mtase; pfam01555 153948001218 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 153948001219 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 153948001220 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 153948001221 head completion protein; Provisional; Region: 4; PHA02552 153948001222 anthranilate synthase component I; Provisional; Region: PRK13565 153948001223 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 153948001224 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 153948001225 phosphoglycolate phosphatase; Provisional; Region: PRK13222 153948001226 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 153948001227 motif II; other site 153948001228 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 153948001229 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 153948001230 substrate binding site [chemical binding]; other site 153948001231 hexamer interface [polypeptide binding]; other site 153948001232 metal binding site [ion binding]; metal-binding site 153948001233 Transposase; Region: HTH_Tnp_1; cl17663 153948001234 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 153948001235 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 153948001236 Predicted methyltransferases [General function prediction only]; Region: COG0313 153948001237 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 153948001238 putative SAM binding site [chemical binding]; other site 153948001239 homodimer interface [polypeptide binding]; other site 153948001240 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 153948001241 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 153948001242 dimer interface [polypeptide binding]; other site 153948001243 active site 153948001244 metal binding site [ion binding]; metal-binding site 153948001245 glutathione binding site [chemical binding]; other site 153948001246 Rubredoxin [Energy production and conversion]; Region: COG1773 153948001247 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 153948001248 iron binding site [ion binding]; other site 153948001249 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 153948001250 dimer interface [polypeptide binding]; other site 153948001251 substrate binding site [chemical binding]; other site 153948001252 ATP binding site [chemical binding]; other site 153948001253 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 153948001254 thiamine phosphate binding site [chemical binding]; other site 153948001255 active site 153948001256 pyrophosphate binding site [ion binding]; other site 153948001257 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 153948001258 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 153948001259 inhibitor-cofactor binding pocket; inhibition site 153948001260 pyridoxal 5'-phosphate binding site [chemical binding]; other site 153948001261 catalytic residue [active] 153948001262 Cytochrome c553 [Energy production and conversion]; Region: COG2863 153948001263 Cytochrome c; Region: Cytochrom_C; cl11414 153948001264 Sporulation related domain; Region: SPOR; pfam05036 153948001265 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 153948001266 active site 153948001267 ribonuclease PH; Reviewed; Region: rph; PRK00173 153948001268 Ribonuclease PH; Region: RNase_PH_bact; cd11362 153948001269 hexamer interface [polypeptide binding]; other site 153948001270 active site 153948001271 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 153948001272 active site 153948001273 dimerization interface [polypeptide binding]; other site 153948001274 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 153948001275 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 153948001276 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 153948001277 PEP-CTERM motif; Region: VPEP; pfam07589 153948001278 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 153948001279 S-formylglutathione hydrolase; Region: PLN02442 153948001280 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 153948001281 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 153948001282 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 153948001283 substrate binding site [chemical binding]; other site 153948001284 catalytic Zn binding site [ion binding]; other site 153948001285 NAD binding site [chemical binding]; other site 153948001286 structural Zn binding site [ion binding]; other site 153948001287 dimer interface [polypeptide binding]; other site 153948001288 Low molecular weight phosphatase family; Region: LMWPc; cd00115 153948001289 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 153948001290 active site 153948001291 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 153948001292 active site 153948001293 ATP binding site [chemical binding]; other site 153948001294 substrate binding site [chemical binding]; other site 153948001295 activation loop (A-loop); other site 153948001296 Glyoxal oxidase N-terminus; Region: Glyoxal_oxid_N; pfam07250 153948001297 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 153948001298 HDOD domain; Region: HDOD; pfam08668 153948001299 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 153948001300 active site 153948001301 ribulose/triose binding site [chemical binding]; other site 153948001302 phosphate binding site [ion binding]; other site 153948001303 substrate (anthranilate) binding pocket [chemical binding]; other site 153948001304 product (indole) binding pocket [chemical binding]; other site 153948001305 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 153948001306 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 153948001307 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 153948001308 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 153948001309 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 153948001310 glutamine binding [chemical binding]; other site 153948001311 catalytic triad [active] 153948001312 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 153948001313 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 153948001314 dimer interface [polypeptide binding]; other site 153948001315 ssDNA binding site [nucleotide binding]; other site 153948001316 tetramer (dimer of dimers) interface [polypeptide binding]; other site 153948001317 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 153948001318 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 153948001319 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 153948001320 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 153948001321 replicative DNA helicase; Provisional; Region: PRK07004 153948001322 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 153948001323 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 153948001324 Walker A motif; other site 153948001325 ATP binding site [chemical binding]; other site 153948001326 Walker B motif; other site 153948001327 DNA binding loops [nucleotide binding] 153948001328 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 153948001329 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 153948001330 Zn2+ binding site [ion binding]; other site 153948001331 Mg2+ binding site [ion binding]; other site 153948001332 Methyltransferase domain; Region: Methyltransf_26; pfam13659 153948001333 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 153948001334 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 153948001335 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 153948001336 putative dimer interface [polypeptide binding]; other site 153948001337 N-terminal domain interface [polypeptide binding]; other site 153948001338 putative substrate binding pocket (H-site) [chemical binding]; other site 153948001339 glycerate dehydrogenase; Provisional; Region: PRK06487 153948001340 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 153948001341 putative ligand binding site [chemical binding]; other site 153948001342 putative NAD binding site [chemical binding]; other site 153948001343 catalytic site [active] 153948001344 Transposase; Region: HTH_Tnp_1; pfam01527 153948001345 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 153948001346 Transposase; Region: HTH_Tnp_1; cl17663 153948001347 Stf0 sulphotransferase; Region: Sulphotransf; cl01835 153948001348 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 153948001349 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 153948001350 metal binding site [ion binding]; metal-binding site 153948001351 putative dimer interface [polypeptide binding]; other site 153948001352 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 153948001353 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 153948001354 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 153948001355 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 153948001356 Helix-turn-helix domain; Region: HTH_38; pfam13936 153948001357 Integrase core domain; Region: rve; pfam00665 153948001358 transposase/IS protein; Provisional; Region: PRK09183 153948001359 Putative ATP-dependent Lon protease; Region: Lon_2; cl11979 153948001360 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 153948001361 Walker A motif; other site 153948001362 ATP binding site [chemical binding]; other site 153948001363 Walker B motif; other site 153948001364 arginine finger; other site 153948001365 Putative addiction module component; Region: Unstab_antitox; cl09921 153948001366 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 153948001367 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 153948001368 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 153948001369 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 153948001370 ATP binding site [chemical binding]; other site 153948001371 putative Mg++ binding site [ion binding]; other site 153948001372 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 153948001373 nucleotide binding region [chemical binding]; other site 153948001374 ATP-binding site [chemical binding]; other site 153948001375 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 153948001376 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 153948001377 TPR motif; other site 153948001378 binding surface 153948001379 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 153948001380 catalytic core [active] 153948001381 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 153948001382 HlyD family secretion protein; Region: HlyD_3; pfam13437 153948001383 Outer membrane efflux protein; Region: OEP; pfam02321 153948001384 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 153948001385 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 153948001386 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 153948001387 DXD motif; other site 153948001388 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 153948001389 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 153948001390 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 153948001391 Ligand Binding Site [chemical binding]; other site 153948001392 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 153948001393 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 153948001394 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 153948001395 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 153948001396 TPR motif; other site 153948001397 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 153948001398 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 153948001399 ligand binding site [chemical binding]; other site 153948001400 translocation protein TolB; Provisional; Region: tolB; PRK02889 153948001401 TolB amino-terminal domain; Region: TolB_N; pfam04052 153948001402 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 153948001403 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 153948001404 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 153948001405 TolA protein; Region: tolA_full; TIGR02794 153948001406 TonB C terminal; Region: TonB_2; pfam13103 153948001407 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 153948001408 TolR protein; Region: tolR; TIGR02801 153948001409 TolQ protein; Region: tolQ; TIGR02796 153948001410 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 153948001411 active site 153948001412 cysteine synthase B; Region: cysM; TIGR01138 153948001413 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 153948001414 dimer interface [polypeptide binding]; other site 153948001415 pyridoxal 5'-phosphate binding site [chemical binding]; other site 153948001416 catalytic residue [active] 153948001417 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 153948001418 Helix-hairpin-helix motif; Region: HHH; pfam00633 153948001419 folate/biopterin transporter; Region: fbt; TIGR00788 153948001420 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 153948001421 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 153948001422 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 153948001423 protein binding site [polypeptide binding]; other site 153948001424 Uncharacterized conserved protein [Function unknown]; Region: COG0327 153948001425 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 153948001426 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 153948001427 MltA specific insert domain; Region: MltA; smart00925 153948001428 3D domain; Region: 3D; pfam06725 153948001429 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 153948001430 dimerization domain [polypeptide binding]; other site 153948001431 dimer interface [polypeptide binding]; other site 153948001432 catalytic residues [active] 153948001433 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608 153948001434 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 153948001435 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 153948001436 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 153948001437 dimer interface [polypeptide binding]; other site 153948001438 pyridoxal 5'-phosphate binding site [chemical binding]; other site 153948001439 catalytic residue [active] 153948001440 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 153948001441 trimer interface [polypeptide binding]; other site 153948001442 active site 153948001443 substrate binding site [chemical binding]; other site 153948001444 CoA binding site [chemical binding]; other site 153948001445 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 153948001446 Transposase domain (DUF772); Region: DUF772; pfam05598 153948001447 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 153948001448 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 153948001449 Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933 153948001450 Tim44-like domain; Region: Tim44; pfam04280 153948001451 Protein of unknown function (DUF3293); Region: DUF3293; pfam11697 153948001452 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 153948001453 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684 153948001454 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 153948001455 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 153948001456 substrate binding site [chemical binding]; other site 153948001457 dimerization interface [polypeptide binding]; other site 153948001458 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 153948001459 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 153948001460 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 153948001461 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 153948001462 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 153948001463 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 153948001464 Active Sites [active] 153948001465 Response regulator receiver domain; Region: Response_reg; pfam00072 153948001466 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948001467 active site 153948001468 phosphorylation site [posttranslational modification] 153948001469 intermolecular recognition site; other site 153948001470 dimerization interface [polypeptide binding]; other site 153948001471 putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Validated; Region: PRK06567 153948001472 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 153948001473 FAD binding pocket [chemical binding]; other site 153948001474 FAD binding motif [chemical binding]; other site 153948001475 phosphate binding motif [ion binding]; other site 153948001476 beta-alpha-beta structure motif; other site 153948001477 NAD binding pocket [chemical binding]; other site 153948001478 Iron coordination center [ion binding]; other site 153948001479 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 153948001480 putative binding surface; other site 153948001481 active site 153948001482 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 153948001483 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 153948001484 ligand binding site [chemical binding]; other site 153948001485 homodimer interface [polypeptide binding]; other site 153948001486 NAD(P) binding site [chemical binding]; other site 153948001487 trimer interface B [polypeptide binding]; other site 153948001488 trimer interface A [polypeptide binding]; other site 153948001489 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 153948001490 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 153948001491 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 153948001492 PAS fold; Region: PAS_4; pfam08448 153948001493 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 153948001494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 153948001495 isocitrate dehydrogenase; Validated; Region: PRK07362 153948001496 isocitrate dehydrogenase; Reviewed; Region: PRK07006 153948001497 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 153948001498 DNA-binding site [nucleotide binding]; DNA binding site 153948001499 RNA-binding motif; other site 153948001500 Uncharacterized conserved protein [Function unknown]; Region: COG2127 153948001501 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 153948001502 Clp amino terminal domain; Region: Clp_N; pfam02861 153948001503 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 153948001504 Walker A motif; other site 153948001505 ATP binding site [chemical binding]; other site 153948001506 Walker B motif; other site 153948001507 arginine finger; other site 153948001508 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 153948001509 Walker A motif; other site 153948001510 ATP binding site [chemical binding]; other site 153948001511 Walker B motif; other site 153948001512 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 153948001513 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 153948001514 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 153948001515 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 153948001516 HlyD family secretion protein; Region: HlyD_3; pfam13437 153948001517 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 153948001518 Maf-like protein; Region: Maf; pfam02545 153948001519 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 153948001520 active site 153948001521 dimer interface [polypeptide binding]; other site 153948001522 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 153948001523 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 153948001524 putative phosphate acyltransferase; Provisional; Region: PRK05331 153948001525 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 153948001526 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 153948001527 dimer interface [polypeptide binding]; other site 153948001528 active site 153948001529 CoA binding pocket [chemical binding]; other site 153948001530 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 153948001531 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 153948001532 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 153948001533 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 153948001534 NAD(P) binding site [chemical binding]; other site 153948001535 homotetramer interface [polypeptide binding]; other site 153948001536 homodimer interface [polypeptide binding]; other site 153948001537 active site 153948001538 acyl carrier protein; Provisional; Region: acpP; PRK00982 153948001539 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 153948001540 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 153948001541 dimer interface [polypeptide binding]; other site 153948001542 active site 153948001543 YceG-like family; Region: YceG; pfam02618 153948001544 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 153948001545 dimerization interface [polypeptide binding]; other site 153948001546 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 153948001547 Ligand binding site; other site 153948001548 Putative Catalytic site; other site 153948001549 DXD motif; other site 153948001550 Predicted membrane protein [Function unknown]; Region: COG2246 153948001551 GtrA-like protein; Region: GtrA; pfam04138 153948001552 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 153948001553 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 153948001554 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 153948001555 O-methyltransferase; Region: Methyltransf_2; pfam00891 153948001556 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 153948001557 hydrophobic ligand binding site; other site 153948001558 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 153948001559 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 153948001560 hypothetical protein; Provisional; Region: PRK05409 153948001561 HDOD domain; Region: HDOD; pfam08668 153948001562 Response regulator receiver domain; Region: Response_reg; pfam00072 153948001563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948001564 active site 153948001565 phosphorylation site [posttranslational modification] 153948001566 intermolecular recognition site; other site 153948001567 dimerization interface [polypeptide binding]; other site 153948001568 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 153948001569 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 153948001570 metal binding site [ion binding]; metal-binding site 153948001571 active site 153948001572 I-site; other site 153948001573 HAMP domain; Region: HAMP; pfam00672 153948001574 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 153948001575 dimer interface [polypeptide binding]; other site 153948001576 phosphorylation site [posttranslational modification] 153948001577 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 153948001578 ATP binding site [chemical binding]; other site 153948001579 Mg2+ binding site [ion binding]; other site 153948001580 G-X-G motif; other site 153948001581 Response regulator receiver domain; Region: Response_reg; pfam00072 153948001582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948001583 active site 153948001584 phosphorylation site [posttranslational modification] 153948001585 intermolecular recognition site; other site 153948001586 dimerization interface [polypeptide binding]; other site 153948001587 Response regulator receiver domain; Region: Response_reg; pfam00072 153948001588 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948001589 active site 153948001590 phosphorylation site [posttranslational modification] 153948001591 intermolecular recognition site; other site 153948001592 dimerization interface [polypeptide binding]; other site 153948001593 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 153948001594 putative binding surface; other site 153948001595 active site 153948001596 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 153948001597 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 153948001598 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 153948001599 N-terminal plug; other site 153948001600 ligand-binding site [chemical binding]; other site 153948001601 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 153948001602 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 153948001603 Walker A/P-loop; other site 153948001604 ATP binding site [chemical binding]; other site 153948001605 Q-loop/lid; other site 153948001606 ABC transporter signature motif; other site 153948001607 Walker B; other site 153948001608 D-loop; other site 153948001609 H-loop/switch region; other site 153948001610 Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916 153948001611 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 153948001612 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 153948001613 L,D-transpeptidase; Provisional; Region: PRK10260 153948001614 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 153948001615 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 153948001616 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 153948001617 trimer interface [polypeptide binding]; other site 153948001618 eyelet of channel; other site 153948001619 Protein of unknown function (DUF2806); Region: DUF2806; cl12560 153948001620 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 153948001621 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 153948001622 MOFRL family; Region: MOFRL; pfam05161 153948001623 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 153948001624 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 153948001625 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 153948001626 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 153948001627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 153948001628 Major Facilitator Superfamily; Region: MFS_1; pfam07690 153948001629 putative substrate translocation pore; other site 153948001630 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 153948001631 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 153948001632 dimer interface [polypeptide binding]; other site 153948001633 ssDNA binding site [nucleotide binding]; other site 153948001634 tetramer (dimer of dimers) interface [polypeptide binding]; other site 153948001635 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 153948001636 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 153948001637 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 153948001638 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 153948001639 FeS/SAM binding site; other site 153948001640 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 153948001641 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 153948001642 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 153948001643 active site 153948001644 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 153948001645 hopanoid biosynthesis associated membrane protein HpnM; Region: HpnM; TIGR03481 153948001646 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 153948001647 16S rRNA methyltransferase B; Provisional; Region: PRK14901 153948001648 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 153948001649 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 153948001650 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 153948001651 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 153948001652 active site 153948001653 substrate binding site [chemical binding]; other site 153948001654 cosubstrate binding site; other site 153948001655 catalytic site [active] 153948001656 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 153948001657 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 153948001658 dimerization interface [polypeptide binding]; other site 153948001659 putative ATP binding site [chemical binding]; other site 153948001660 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 153948001661 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 153948001662 putative active site [active] 153948001663 Zn binding site [ion binding]; other site 153948001664 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 153948001665 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 153948001666 inhibitor-cofactor binding pocket; inhibition site 153948001667 pyridoxal 5'-phosphate binding site [chemical binding]; other site 153948001668 catalytic residue [active] 153948001669 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 153948001670 Domain of unknown function DUF20; Region: UPF0118; pfam01594 153948001671 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 153948001672 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 153948001673 Walker A motif; other site 153948001674 ATP binding site [chemical binding]; other site 153948001675 Walker B motif; other site 153948001676 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 153948001677 arginine finger; other site 153948001678 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 153948001679 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 153948001680 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 153948001681 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 153948001682 dimer interface [polypeptide binding]; other site 153948001683 putative anticodon binding site; other site 153948001684 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 153948001685 motif 1; other site 153948001686 active site 153948001687 motif 2; other site 153948001688 motif 3; other site 153948001689 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 153948001690 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948001691 active site 153948001692 phosphorylation site [posttranslational modification] 153948001693 intermolecular recognition site; other site 153948001694 dimerization interface [polypeptide binding]; other site 153948001695 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 153948001696 DNA binding residues [nucleotide binding] 153948001697 dimerization interface [polypeptide binding]; other site 153948001698 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 153948001699 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 153948001700 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 153948001701 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 153948001702 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 153948001703 Cu(I) binding site [ion binding]; other site 153948001704 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 153948001705 dimerization interface [polypeptide binding]; other site 153948001706 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 153948001707 GAF domain; Region: GAF; pfam01590 153948001708 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 153948001709 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 153948001710 metal binding site [ion binding]; metal-binding site 153948001711 active site 153948001712 I-site; other site 153948001713 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 153948001714 active pocket/dimerization site; other site 153948001715 active site 153948001716 phosphorylation site [posttranslational modification] 153948001717 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 153948001718 dimerization domain swap beta strand [polypeptide binding]; other site 153948001719 regulatory protein interface [polypeptide binding]; other site 153948001720 active site 153948001721 regulatory phosphorylation site [posttranslational modification]; other site 153948001722 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 153948001723 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 153948001724 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 153948001725 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 153948001726 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 153948001727 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 153948001728 Methyltransferase domain; Region: Methyltransf_23; pfam13489 153948001729 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 153948001730 S-adenosylmethionine binding site [chemical binding]; other site 153948001731 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 153948001732 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 153948001733 dinuclear metal binding motif [ion binding]; other site 153948001734 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 153948001735 sulfotransferase; Region: PLN02164 153948001736 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 153948001737 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 153948001738 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 153948001739 putative active site [active] 153948001740 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 153948001741 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 153948001742 motif II; other site 153948001743 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 153948001744 extended (e) SDRs; Region: SDR_e; cd08946 153948001745 NAD(P) binding site [chemical binding]; other site 153948001746 active site 153948001747 substrate binding site [chemical binding]; other site 153948001748 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 153948001749 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 153948001750 putative ligand binding site [chemical binding]; other site 153948001751 putative NAD binding site [chemical binding]; other site 153948001752 catalytic site [active] 153948001753 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 153948001754 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 153948001755 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 153948001756 Ligand binding site; other site 153948001757 oligomer interface; other site 153948001758 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 153948001759 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 153948001760 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 153948001761 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 153948001762 Probable Catalytic site; other site 153948001763 metal-binding site 153948001764 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 153948001765 O-Antigen ligase; Region: Wzy_C; pfam04932 153948001766 Transposase domain (DUF772); Region: DUF772; pfam05598 153948001767 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 153948001768 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 153948001769 Methyltransferase domain; Region: Methyltransf_23; pfam13489 153948001770 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 153948001771 S-adenosylmethionine binding site [chemical binding]; other site 153948001772 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 153948001773 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 153948001774 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 153948001775 S-adenosylmethionine binding site [chemical binding]; other site 153948001776 Domain of unknown function (DUF2024); Region: DUF2024; pfam09630 153948001777 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 153948001778 ArsC family; Region: ArsC; pfam03960 153948001779 catalytic residues [active] 153948001780 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 153948001781 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 153948001782 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 153948001783 RimM N-terminal domain; Region: RimM; pfam01782 153948001784 PRC-barrel domain; Region: PRC; pfam05239 153948001785 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 153948001786 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 153948001787 Cysteine-rich domain; Region: CCG; pfam02754 153948001788 Cysteine-rich domain; Region: CCG; pfam02754 153948001789 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 153948001790 diiron binding motif [ion binding]; other site 153948001791 hypothetical protein; Validated; Region: PRK00228 153948001792 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 153948001793 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 153948001794 active site 153948001795 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 153948001796 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 153948001797 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 153948001798 dihydroorotase; Provisional; Region: PRK07627 153948001799 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 153948001800 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 153948001801 active site 153948001802 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 153948001803 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 153948001804 active site 153948001805 Zn binding site [ion binding]; other site 153948001806 VacJ like lipoprotein; Region: VacJ; cl01073 153948001807 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 153948001808 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 153948001809 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 153948001810 intracellular septation protein A; Reviewed; Region: PRK00259 153948001811 YciI-like protein; Reviewed; Region: PRK11370 153948001812 SurA N-terminal domain; Region: SurA_N_3; cl07813 153948001813 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 153948001814 alanine racemase; Reviewed; Region: dadX; PRK03646 153948001815 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 153948001816 active site 153948001817 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 153948001818 substrate binding site [chemical binding]; other site 153948001819 catalytic residues [active] 153948001820 dimer interface [polypeptide binding]; other site 153948001821 lysophospholipid transporter LplT; Provisional; Region: PRK11195 153948001822 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 153948001823 Fe-S cluster binding site [ion binding]; other site 153948001824 active site 153948001825 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 153948001826 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 153948001827 Coenzyme A binding pocket [chemical binding]; other site 153948001828 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 153948001829 Glycoprotease family; Region: Peptidase_M22; pfam00814 153948001830 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 153948001831 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 153948001832 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 153948001833 homotrimer interaction site [polypeptide binding]; other site 153948001834 zinc binding site [ion binding]; other site 153948001835 CDP-binding sites; other site 153948001836 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 153948001837 substrate binding site; other site 153948001838 dimer interface; other site 153948001839 peptide chain release factor 2; Validated; Region: prfB; PRK00578 153948001840 This domain is found in peptide chain release factors; Region: PCRF; smart00937 153948001841 RF-1 domain; Region: RF-1; pfam00472 153948001842 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 153948001843 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 153948001844 tandem repeat interface [polypeptide binding]; other site 153948001845 oligomer interface [polypeptide binding]; other site 153948001846 active site residues [active] 153948001847 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722 153948001848 Transposase domain (DUF772); Region: DUF772; pfam05598 153948001849 Winged helix-turn helix; Region: HTH_29; pfam13551 153948001850 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 153948001851 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 153948001852 NADP binding site [chemical binding]; other site 153948001853 active site 153948001854 putative substrate binding site [chemical binding]; other site 153948001855 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 153948001856 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 153948001857 NAD binding site [chemical binding]; other site 153948001858 substrate binding site [chemical binding]; other site 153948001859 homodimer interface [polypeptide binding]; other site 153948001860 active site 153948001861 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 153948001862 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 153948001863 Ligand Binding Site [chemical binding]; other site 153948001864 TilS substrate binding domain; Region: TilS; pfam09179 153948001865 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 153948001866 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 153948001867 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 153948001868 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 153948001869 SelR domain; Region: SelR; pfam01641 153948001870 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 153948001871 Cupin superfamily protein; Region: Cupin_4; pfam08007 153948001872 Transposase domain (DUF772); Region: DUF772; pfam05598 153948001873 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 153948001874 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 153948001875 active site 153948001876 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 153948001877 active site 153948001878 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 153948001879 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 153948001880 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 153948001881 S-adenosylmethionine binding site [chemical binding]; other site 153948001882 methionine sulfoxide reductase B; Provisional; Region: PRK00222 153948001883 SelR domain; Region: SelR; pfam01641 153948001884 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 153948001885 Ammonia monooxygenase/methane monooxygenase, subunit C; Region: AmoC; pfam04896 153948001886 methane monooxygenase/ammonia monooxygenase, subunit A; Region: CH4_NH3mon_ox_A; TIGR03080 153948001887 methane monooxygenase/ammonia monooxygenase, subunit B; Region: CH4_NH3mon_ox_B; TIGR03079 153948001888 Monooxygenase subunit B protein; Region: Monooxygenase_B; pfam04744 153948001889 CopC domain; Region: CopC; pfam04234 153948001890 Copper resistance protein D; Region: CopD; cl00563 153948001891 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 153948001892 Cytochrome c; Region: Cytochrom_C; pfam00034 153948001893 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 153948001894 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 153948001895 metal-binding site [ion binding] 153948001896 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cl03727 153948001897 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 153948001898 sec-independent translocase; Provisional; Region: tatB; PRK00404 153948001899 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 153948001900 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 153948001901 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 153948001902 nucleotide binding site/active site [active] 153948001903 HIT family signature motif; other site 153948001904 catalytic residue [active] 153948001905 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 153948001906 metal binding site [ion binding]; metal-binding site 153948001907 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 153948001908 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 153948001909 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 153948001910 substrate binding site [chemical binding]; other site 153948001911 glutamase interaction surface [polypeptide binding]; other site 153948001912 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 153948001913 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 153948001914 catalytic residues [active] 153948001915 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 153948001916 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 153948001917 putative active site [active] 153948001918 oxyanion strand; other site 153948001919 catalytic triad [active] 153948001920 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 153948001921 putative active site pocket [active] 153948001922 4-fold oligomerization interface [polypeptide binding]; other site 153948001923 metal binding residues [ion binding]; metal-binding site 153948001924 3-fold/trimer interface [polypeptide binding]; other site 153948001925 histidinol-phosphate aminotransferase; Provisional; Region: PRK04870 153948001926 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 153948001927 pyridoxal 5'-phosphate binding site [chemical binding]; other site 153948001928 homodimer interface [polypeptide binding]; other site 153948001929 catalytic residue [active] 153948001930 Uncharacterized conserved protein [Function unknown]; Region: COG1565 153948001931 pteridine reductase; Provisional; Region: PRK09135 153948001932 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 153948001933 NADP binding site [chemical binding]; other site 153948001934 substrate binding pocket [chemical binding]; other site 153948001935 active site 153948001936 Chorismate lyase; Region: Chor_lyase; cl01230 153948001937 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 153948001938 UbiA prenyltransferase family; Region: UbiA; pfam01040 153948001939 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 153948001940 Protein of unknown function, DUF486; Region: DUF486; pfam04342 153948001941 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 153948001942 OstA-like protein; Region: OstA; cl00844 153948001943 Organic solvent tolerance protein; Region: OstA_C; pfam04453 153948001944 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 153948001945 SurA N-terminal domain; Region: SurA_N; pfam09312 153948001946 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 153948001947 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 153948001948 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 153948001949 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 153948001950 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 153948001951 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 153948001952 S-adenosylmethionine binding site [chemical binding]; other site 153948001953 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 153948001954 active site 153948001955 catalytic residues [active] 153948001956 Putative zinc-finger; Region: zf-HC2; pfam13490 153948001957 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 153948001958 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 153948001959 DNA binding residues [nucleotide binding] 153948001960 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 153948001961 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 153948001962 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 153948001963 CHASE domain; Region: CHASE; cl01369 153948001964 PAS domain S-box; Region: sensory_box; TIGR00229 153948001965 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 153948001966 putative active site [active] 153948001967 heme pocket [chemical binding]; other site 153948001968 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 153948001969 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 153948001970 dimer interface [polypeptide binding]; other site 153948001971 phosphorylation site [posttranslational modification] 153948001972 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 153948001973 ATP binding site [chemical binding]; other site 153948001974 Mg2+ binding site [ion binding]; other site 153948001975 G-X-G motif; other site 153948001976 HDOD domain; Region: HDOD; pfam08668 153948001977 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 153948001978 Zn2+ binding site [ion binding]; other site 153948001979 Mg2+ binding site [ion binding]; other site 153948001980 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 153948001981 Sulfatase; Region: Sulfatase; pfam00884 153948001982 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 153948001983 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 153948001984 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 153948001985 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 153948001986 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 153948001987 FtsX-like permease family; Region: FtsX; pfam02687 153948001988 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 153948001989 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 153948001990 Walker A/P-loop; other site 153948001991 ATP binding site [chemical binding]; other site 153948001992 Q-loop/lid; other site 153948001993 ABC transporter signature motif; other site 153948001994 Walker B; other site 153948001995 D-loop; other site 153948001996 H-loop/switch region; other site 153948001997 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 153948001998 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 153948001999 HlyD family secretion protein; Region: HlyD_3; pfam13437 153948002000 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 153948002001 Peptidase family M48; Region: Peptidase_M48; cl12018 153948002002 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 153948002003 TPR motif; other site 153948002004 binding surface 153948002005 NAD synthetase; Provisional; Region: PRK13981 153948002006 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 153948002007 multimer interface [polypeptide binding]; other site 153948002008 active site 153948002009 catalytic triad [active] 153948002010 protein interface 1 [polypeptide binding]; other site 153948002011 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 153948002012 homodimer interface [polypeptide binding]; other site 153948002013 NAD binding pocket [chemical binding]; other site 153948002014 ATP binding pocket [chemical binding]; other site 153948002015 Mg binding site [ion binding]; other site 153948002016 active-site loop [active] 153948002017 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 153948002018 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 153948002019 active site 153948002020 substrate binding site [chemical binding]; other site 153948002021 metal binding site [ion binding]; metal-binding site 153948002022 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 153948002023 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 153948002024 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 153948002025 homodimer interface [polypeptide binding]; other site 153948002026 substrate-cofactor binding pocket; other site 153948002027 catalytic residue [active] 153948002028 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 153948002029 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 153948002030 Sulfate transporter family; Region: Sulfate_transp; pfam00916 153948002031 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 153948002032 Ligand Binding Site [chemical binding]; other site 153948002033 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 153948002034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948002035 active site 153948002036 phosphorylation site [posttranslational modification] 153948002037 intermolecular recognition site; other site 153948002038 dimerization interface [polypeptide binding]; other site 153948002039 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 153948002040 DNA binding residues [nucleotide binding] 153948002041 dimerization interface [polypeptide binding]; other site 153948002042 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 153948002043 Histidine kinase; Region: HisKA_3; pfam07730 153948002044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 153948002045 ATP binding site [chemical binding]; other site 153948002046 Mg2+ binding site [ion binding]; other site 153948002047 G-X-G motif; other site 153948002048 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 153948002049 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 153948002050 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 153948002051 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 153948002052 RNA binding surface [nucleotide binding]; other site 153948002053 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 153948002054 intersubunit interface [polypeptide binding]; other site 153948002055 active site 153948002056 Zn2+ binding site [ion binding]; other site 153948002057 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 153948002058 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 153948002059 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 153948002060 Zn2+ binding site [ion binding]; other site 153948002061 Mg2+ binding site [ion binding]; other site 153948002062 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 153948002063 metal ion-dependent adhesion site (MIDAS); other site 153948002064 MoxR-like ATPases [General function prediction only]; Region: COG0714 153948002065 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 153948002066 Walker A motif; other site 153948002067 ATP binding site [chemical binding]; other site 153948002068 Walker B motif; other site 153948002069 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 153948002070 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 153948002071 multimerization interface [polypeptide binding]; other site 153948002072 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 153948002073 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 153948002074 dimer interface [polypeptide binding]; other site 153948002075 catalytic residue [active] 153948002076 metal binding site [ion binding]; metal-binding site 153948002077 Transcriptional regulator [Transcription]; Region: LysR; COG0583 153948002078 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 153948002079 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 153948002080 putative dimerization interface [polypeptide binding]; other site 153948002081 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 153948002082 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 153948002083 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 153948002084 FeS/SAM binding site; other site 153948002085 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851 153948002086 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 153948002087 RNA binding site [nucleotide binding]; other site 153948002088 active site 153948002089 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 153948002090 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 153948002091 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 153948002092 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 153948002093 translation initiation factor IF-2; Validated; Region: infB; PRK05306 153948002094 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 153948002095 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 153948002096 G1 box; other site 153948002097 putative GEF interaction site [polypeptide binding]; other site 153948002098 GTP/Mg2+ binding site [chemical binding]; other site 153948002099 Switch I region; other site 153948002100 G2 box; other site 153948002101 G3 box; other site 153948002102 Switch II region; other site 153948002103 G4 box; other site 153948002104 G5 box; other site 153948002105 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 153948002106 Translation-initiation factor 2; Region: IF-2; pfam11987 153948002107 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 153948002108 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 153948002109 NusA N-terminal domain; Region: NusA_N; pfam08529 153948002110 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 153948002111 RNA binding site [nucleotide binding]; other site 153948002112 homodimer interface [polypeptide binding]; other site 153948002113 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 153948002114 G-X-X-G motif; other site 153948002115 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 153948002116 G-X-X-G motif; other site 153948002117 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 153948002118 ribosome maturation protein RimP; Reviewed; Region: PRK00092 153948002119 Sm and related proteins; Region: Sm_like; cl00259 153948002120 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 153948002121 putative oligomer interface [polypeptide binding]; other site 153948002122 putative RNA binding site [nucleotide binding]; other site 153948002123 acetyl-CoA synthetase; Provisional; Region: PRK00174 153948002124 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 153948002125 active site 153948002126 CoA binding site [chemical binding]; other site 153948002127 acyl-activating enzyme (AAE) consensus motif; other site 153948002128 AMP binding site [chemical binding]; other site 153948002129 acetate binding site [chemical binding]; other site 153948002130 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 153948002131 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 153948002132 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 153948002133 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 153948002134 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 153948002135 Predicted transcriptional regulator [Transcription]; Region: COG2345 153948002136 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 153948002137 putative DNA binding site [nucleotide binding]; other site 153948002138 putative Zn2+ binding site [ion binding]; other site 153948002139 MASE1; Region: MASE1; pfam05231 153948002140 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 153948002141 PAS fold; Region: PAS_3; pfam08447 153948002142 putative active site [active] 153948002143 heme pocket [chemical binding]; other site 153948002144 PAS fold; Region: PAS_4; pfam08448 153948002145 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 153948002146 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 153948002147 metal binding site [ion binding]; metal-binding site 153948002148 active site 153948002149 I-site; other site 153948002150 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 153948002151 nitrosocyanin; Region: nitroso_cyanin; TIGR03096 153948002152 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 153948002153 rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396 153948002154 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 153948002155 COQ9; Region: COQ9; pfam08511 153948002156 Methyltransferase domain; Region: Methyltransf_24; pfam13578 153948002157 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 153948002158 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 153948002159 Coenzyme A binding pocket [chemical binding]; other site 153948002160 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 153948002161 VacJ like lipoprotein; Region: VacJ; cl01073 153948002162 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 153948002163 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 153948002164 Active site cavity [active] 153948002165 catalytic acid [active] 153948002166 hopanoid-associated phosphorylase; Region: HpnG; TIGR03468 153948002167 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 153948002168 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 153948002169 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 153948002170 Walker A/P-loop; other site 153948002171 ATP binding site [chemical binding]; other site 153948002172 Q-loop/lid; other site 153948002173 ABC transporter signature motif; other site 153948002174 Walker B; other site 153948002175 D-loop; other site 153948002176 H-loop/switch region; other site 153948002177 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 153948002178 RTX toxin acyltransferase family; Region: HlyC; cl01131 153948002179 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 153948002180 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 153948002181 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 153948002182 Walker A/P-loop; other site 153948002183 ATP binding site [chemical binding]; other site 153948002184 Q-loop/lid; other site 153948002185 ABC transporter signature motif; other site 153948002186 Walker B; other site 153948002187 D-loop; other site 153948002188 H-loop/switch region; other site 153948002189 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 153948002190 FtsX-like permease family; Region: FtsX; pfam02687 153948002191 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 153948002192 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 153948002193 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 153948002194 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 153948002195 amino acid transporter; Region: 2A0306; TIGR00909 153948002196 Haemolytic domain; Region: Haemolytic; pfam01809 153948002197 Transposase domain (DUF772); Region: DUF772; pfam05598 153948002198 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 153948002199 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 153948002200 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 153948002201 GIY-YIG motif/motif A; other site 153948002202 putative active site [active] 153948002203 putative metal binding site [ion binding]; other site 153948002204 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 153948002205 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 153948002206 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 153948002207 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 153948002208 active site 153948002209 NTP binding site [chemical binding]; other site 153948002210 metal binding triad [ion binding]; metal-binding site 153948002211 antibiotic binding site [chemical binding]; other site 153948002212 Protein of unknown function DUF86; Region: DUF86; pfam01934 153948002213 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 153948002214 DEAD-like helicases superfamily; Region: DEXDc; smart00487 153948002215 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 153948002216 ATP binding site [chemical binding]; other site 153948002217 putative Mg++ binding site [ion binding]; other site 153948002218 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 153948002219 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 153948002220 dimer interface [polypeptide binding]; other site 153948002221 active site 153948002222 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 153948002223 catalytic residues [active] 153948002224 substrate binding site [chemical binding]; other site 153948002225 pyruvate dehydrogenase; Provisional; Region: PRK06546 153948002226 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 153948002227 PYR/PP interface [polypeptide binding]; other site 153948002228 tetramer interface [polypeptide binding]; other site 153948002229 dimer interface [polypeptide binding]; other site 153948002230 TPP binding site [chemical binding]; other site 153948002231 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 153948002232 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 153948002233 TPP-binding site [chemical binding]; other site 153948002234 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 153948002235 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 153948002236 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 153948002237 active site 153948002238 HIGH motif; other site 153948002239 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 153948002240 active site 153948002241 KMSKS motif; other site 153948002242 acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098 153948002243 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 153948002244 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922 153948002245 acyl-activating enzyme (AAE) consensus motif; other site 153948002246 acyl-activating enzyme (AAE) consensus motif; other site 153948002247 putative AMP binding site [chemical binding]; other site 153948002248 putative active site [active] 153948002249 putative CoA binding site [chemical binding]; other site 153948002250 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 153948002251 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 153948002252 dimer interface [polypeptide binding]; other site 153948002253 active site 153948002254 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 153948002255 catalytic residues [active] 153948002256 substrate binding site [chemical binding]; other site 153948002257 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 153948002258 PBP superfamily domain; Region: PBP_like_2; cl17296 153948002259 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 153948002260 PAS domain S-box; Region: sensory_box; TIGR00229 153948002261 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 153948002262 putative active site [active] 153948002263 heme pocket [chemical binding]; other site 153948002264 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 153948002265 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 153948002266 metal binding site [ion binding]; metal-binding site 153948002267 active site 153948002268 I-site; other site 153948002269 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 153948002270 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cl00208 153948002271 CAS motifs; other site 153948002272 active site 153948002273 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 153948002274 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 153948002275 metal binding site [ion binding]; metal-binding site 153948002276 active site 153948002277 I-site; other site 153948002278 Uncharacterized conserved protein [Function unknown]; Region: COG0062 153948002279 putative carbohydrate kinase; Provisional; Region: PRK10565 153948002280 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 153948002281 putative substrate binding site [chemical binding]; other site 153948002282 putative ATP binding site [chemical binding]; other site 153948002283 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 153948002284 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 153948002285 dimerization interface [polypeptide binding]; other site 153948002286 ATP binding site [chemical binding]; other site 153948002287 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 153948002288 dimerization interface [polypeptide binding]; other site 153948002289 ATP binding site [chemical binding]; other site 153948002290 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 153948002291 putative active site [active] 153948002292 catalytic triad [active] 153948002293 Protein of unknown function, DUF399; Region: DUF399; pfam04187 153948002294 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 153948002295 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 153948002296 Zn binding site [ion binding]; other site 153948002297 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 153948002298 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 153948002299 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 153948002300 HlyD family secretion protein; Region: HlyD_3; pfam13437 153948002301 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 153948002302 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 153948002303 PEP-CTERM motif; Region: VPEP; pfam07589 153948002304 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 153948002305 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 153948002306 Tetramer interface [polypeptide binding]; other site 153948002307 active site 153948002308 FMN-binding site [chemical binding]; other site 153948002309 conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729 153948002310 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 153948002311 putative catalytic site [active] 153948002312 putative metal binding site [ion binding]; other site 153948002313 putative phosphate binding site [ion binding]; other site 153948002314 A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603 153948002315 ligand binding surface [chemical binding]; other site 153948002316 GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080 153948002317 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 153948002318 putative C-terminal domain interface [polypeptide binding]; other site 153948002319 putative GSH binding site [chemical binding]; other site 153948002320 putative dimer interface [polypeptide binding]; other site 153948002321 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 153948002322 putative N-terminal domain interface [polypeptide binding]; other site 153948002323 Predicted transcriptional regulators [Transcription]; Region: COG1733 153948002324 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 153948002325 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 153948002326 CNP1-like family; Region: CNP1; pfam08750 153948002327 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 153948002328 Cysteine-rich domain; Region: CCG; pfam02754 153948002329 Cysteine-rich domain; Region: CCG; pfam02754 153948002330 Protein of unknown function (DUF3501); Region: DUF3501; pfam12007 153948002331 Rubrerythrin [Energy production and conversion]; Region: COG1592 153948002332 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 153948002333 binuclear metal center [ion binding]; other site 153948002334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 153948002335 putative substrate translocation pore; other site 153948002336 Major Facilitator Superfamily; Region: MFS_1; pfam07690 153948002337 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 153948002338 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 153948002339 substrate binding site [chemical binding]; other site 153948002340 ligand binding site [chemical binding]; other site 153948002341 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 153948002342 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 153948002343 substrate binding site [chemical binding]; other site 153948002344 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 153948002345 tartrate dehydrogenase; Region: TTC; TIGR02089 153948002346 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 153948002347 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 153948002348 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 153948002349 FimV N-terminal domain; Region: FimV_core; TIGR03505 153948002350 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 153948002351 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 153948002352 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 153948002353 dimerization interface 3.5A [polypeptide binding]; other site 153948002354 active site 153948002355 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 153948002356 active site 153948002357 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 153948002358 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 153948002359 pyridoxal 5'-phosphate binding site [chemical binding]; other site 153948002360 catalytic residue [active] 153948002361 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 153948002362 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 153948002363 substrate binding site [chemical binding]; other site 153948002364 active site 153948002365 catalytic residues [active] 153948002366 heterodimer interface [polypeptide binding]; other site 153948002367 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 153948002368 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 153948002369 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 153948002370 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 153948002371 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 153948002372 Sporulation related domain; Region: SPOR; pfam05036 153948002373 Colicin V production protein; Region: Colicin_V; pfam02674 153948002374 amidophosphoribosyltransferase; Provisional; Region: PRK09246 153948002375 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 153948002376 active site 153948002377 tetramer interface [polypeptide binding]; other site 153948002378 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 153948002379 active site 153948002380 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 153948002381 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 153948002382 homodimer interface [polypeptide binding]; other site 153948002383 substrate-cofactor binding pocket; other site 153948002384 pyridoxal 5'-phosphate binding site [chemical binding]; other site 153948002385 catalytic residue [active] 153948002386 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 153948002387 substrate binding site [chemical binding]; other site 153948002388 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 153948002389 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 153948002390 substrate binding site [chemical binding]; other site 153948002391 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 153948002392 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 153948002393 active site 153948002394 HIGH motif; other site 153948002395 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 153948002396 KMSKS motif; other site 153948002397 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 153948002398 tRNA binding surface [nucleotide binding]; other site 153948002399 anticodon binding site; other site 153948002400 Methyltransferase domain; Region: Methyltransf_18; pfam12847 153948002401 flagellar motor protein MotB; Validated; Region: motB; PRK09041 153948002402 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 153948002403 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 153948002404 ligand binding site [chemical binding]; other site 153948002405 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 153948002406 flagellar motor protein MotA; Validated; Region: PRK09110 153948002407 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 153948002408 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 153948002409 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 153948002410 Walker A/P-loop; other site 153948002411 ATP binding site [chemical binding]; other site 153948002412 Q-loop/lid; other site 153948002413 ABC transporter signature motif; other site 153948002414 Walker B; other site 153948002415 D-loop; other site 153948002416 H-loop/switch region; other site 153948002417 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 153948002418 putative cation:proton antiport protein; Provisional; Region: PRK10669 153948002419 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 153948002420 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 153948002421 TrkA-N domain; Region: TrkA_N; pfam02254 153948002422 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 153948002423 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 153948002424 Transposase; Region: HTH_Tnp_1; pfam01527 153948002425 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 153948002426 Helix-turn-helix domain; Region: HTH_39; pfam14090 153948002427 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 153948002428 integrase; Provisional; Region: PRK09692 153948002429 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 153948002430 active site 153948002431 Int/Topo IB signature motif; other site 153948002432 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 153948002433 Transposase; Region: HTH_Tnp_1; pfam01527 153948002434 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 153948002435 Helix-turn-helix domain; Region: HTH_38; pfam13936 153948002436 Homeodomain-like domain; Region: HTH_32; pfam13565 153948002437 Integrase core domain; Region: rve; pfam00665 153948002438 MEKHLA domain; Region: MEKHLA; pfam08670 153948002439 L-aspartate oxidase; Provisional; Region: PRK09077 153948002440 L-aspartate oxidase; Provisional; Region: PRK06175 153948002441 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 153948002442 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 153948002443 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 153948002444 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 153948002445 DNA binding residues [nucleotide binding] 153948002446 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 153948002447 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 153948002448 anti-sigma E factor; Provisional; Region: rseB; PRK09455 153948002449 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 153948002450 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 153948002451 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 153948002452 protein binding site [polypeptide binding]; other site 153948002453 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 153948002454 protein binding site [polypeptide binding]; other site 153948002455 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 153948002456 GTP-binding protein LepA; Provisional; Region: PRK05433 153948002457 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 153948002458 G1 box; other site 153948002459 putative GEF interaction site [polypeptide binding]; other site 153948002460 GTP/Mg2+ binding site [chemical binding]; other site 153948002461 Switch I region; other site 153948002462 G2 box; other site 153948002463 G3 box; other site 153948002464 Switch II region; other site 153948002465 G4 box; other site 153948002466 G5 box; other site 153948002467 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 153948002468 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 153948002469 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 153948002470 signal peptidase I; Provisional; Region: PRK10861 153948002471 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 153948002472 Catalytic site [active] 153948002473 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 153948002474 ribonuclease III; Reviewed; Region: rnc; PRK00102 153948002475 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 153948002476 dimerization interface [polypeptide binding]; other site 153948002477 active site 153948002478 metal binding site [ion binding]; metal-binding site 153948002479 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 153948002480 dsRNA binding site [nucleotide binding]; other site 153948002481 GTPase Era; Reviewed; Region: era; PRK00089 153948002482 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 153948002483 G1 box; other site 153948002484 GTP/Mg2+ binding site [chemical binding]; other site 153948002485 Switch I region; other site 153948002486 G2 box; other site 153948002487 Switch II region; other site 153948002488 G3 box; other site 153948002489 G4 box; other site 153948002490 G5 box; other site 153948002491 KH domain; Region: KH_2; pfam07650 153948002492 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 153948002493 active site 153948002494 hydrophilic channel; other site 153948002495 dimerization interface [polypeptide binding]; other site 153948002496 catalytic residues [active] 153948002497 active site lid [active] 153948002498 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 153948002499 beta-hexosaminidase; Provisional; Region: PRK05337 153948002500 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 153948002501 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 153948002502 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 153948002503 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 153948002504 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 153948002505 hypothetical protein; Provisional; Region: PRK10756 153948002506 CreA protein; Region: CreA; pfam05981 153948002507 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 153948002508 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 153948002509 tRNA; other site 153948002510 putative tRNA binding site [nucleotide binding]; other site 153948002511 putative NADP binding site [chemical binding]; other site 153948002512 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 153948002513 peptide chain release factor 1; Validated; Region: prfA; PRK00591 153948002514 This domain is found in peptide chain release factors; Region: PCRF; smart00937 153948002515 RF-1 domain; Region: RF-1; pfam00472 153948002516 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 153948002517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 153948002518 S-adenosylmethionine binding site [chemical binding]; other site 153948002519 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 153948002520 putative GSH binding site [chemical binding]; other site 153948002521 catalytic residues [active] 153948002522 Predicted membrane protein [Function unknown]; Region: COG1238 153948002523 LicD family; Region: LicD; cl01378 153948002524 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 153948002525 active site 153948002526 nucleotide binding site [chemical binding]; other site 153948002527 HIGH motif; other site 153948002528 KMSKS motif; other site 153948002529 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 153948002530 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 153948002531 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 153948002532 gamma-glutamyl kinase; Provisional; Region: PRK05429 153948002533 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 153948002534 nucleotide binding site [chemical binding]; other site 153948002535 homotetrameric interface [polypeptide binding]; other site 153948002536 putative phosphate binding site [ion binding]; other site 153948002537 putative allosteric binding site; other site 153948002538 PUA domain; Region: PUA; pfam01472 153948002539 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 153948002540 GTP1/OBG; Region: GTP1_OBG; pfam01018 153948002541 Obg GTPase; Region: Obg; cd01898 153948002542 G1 box; other site 153948002543 GTP/Mg2+ binding site [chemical binding]; other site 153948002544 Switch I region; other site 153948002545 G2 box; other site 153948002546 G3 box; other site 153948002547 Switch II region; other site 153948002548 G4 box; other site 153948002549 G5 box; other site 153948002550 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 153948002551 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 153948002552 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 153948002553 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 153948002554 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 153948002555 substrate binding pocket [chemical binding]; other site 153948002556 chain length determination region; other site 153948002557 substrate-Mg2+ binding site; other site 153948002558 catalytic residues [active] 153948002559 aspartate-rich region 1; other site 153948002560 active site lid residues [active] 153948002561 aspartate-rich region 2; other site 153948002562 PAS fold; Region: PAS_4; pfam08448 153948002563 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 153948002564 putative active site [active] 153948002565 heme pocket [chemical binding]; other site 153948002566 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 153948002567 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 153948002568 dimer interface [polypeptide binding]; other site 153948002569 phosphorylation site [posttranslational modification] 153948002570 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 153948002571 ATP binding site [chemical binding]; other site 153948002572 Mg2+ binding site [ion binding]; other site 153948002573 G-X-G motif; other site 153948002574 Response regulator receiver domain; Region: Response_reg; pfam00072 153948002575 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948002576 active site 153948002577 phosphorylation site [posttranslational modification] 153948002578 intermolecular recognition site; other site 153948002579 dimerization interface [polypeptide binding]; other site 153948002580 PAS domain S-box; Region: sensory_box; TIGR00229 153948002581 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 153948002582 putative active site [active] 153948002583 heme pocket [chemical binding]; other site 153948002584 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 153948002585 PAS fold; Region: PAS_3; pfam08447 153948002586 putative active site [active] 153948002587 heme pocket [chemical binding]; other site 153948002588 PAS domain S-box; Region: sensory_box; TIGR00229 153948002589 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 153948002590 dimer interface [polypeptide binding]; other site 153948002591 phosphorylation site [posttranslational modification] 153948002592 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 153948002593 ATP binding site [chemical binding]; other site 153948002594 Mg2+ binding site [ion binding]; other site 153948002595 G-X-G motif; other site 153948002596 Response regulator receiver domain; Region: Response_reg; pfam00072 153948002597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948002598 active site 153948002599 phosphorylation site [posttranslational modification] 153948002600 intermolecular recognition site; other site 153948002601 dimerization interface [polypeptide binding]; other site 153948002602 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948002603 active site 153948002604 phosphorylation site [posttranslational modification] 153948002605 intermolecular recognition site; other site 153948002606 dimerization interface [polypeptide binding]; other site 153948002607 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 153948002608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948002609 active site 153948002610 phosphorylation site [posttranslational modification] 153948002611 intermolecular recognition site; other site 153948002612 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 153948002613 PAS fold; Region: PAS_3; pfam08447 153948002614 putative active site [active] 153948002615 heme pocket [chemical binding]; other site 153948002616 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 153948002617 GAF domain; Region: GAF; pfam01590 153948002618 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 153948002619 PAS domain; Region: PAS_9; pfam13426 153948002620 putative active site [active] 153948002621 heme pocket [chemical binding]; other site 153948002622 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 153948002623 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 153948002624 metal binding site [ion binding]; metal-binding site 153948002625 active site 153948002626 I-site; other site 153948002627 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 153948002628 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 153948002629 catalytic residues [active] 153948002630 Domain of unknown function DUF87; Region: DUF87; pfam01935 153948002631 AAA-like domain; Region: AAA_10; pfam12846 153948002632 Zonular occludens toxin (Zot); Region: Zot; cl17485 153948002633 SIR2-like domain; Region: SIR2_2; pfam13289 153948002634 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 153948002635 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 153948002636 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 153948002637 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 153948002638 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 153948002639 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 153948002640 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 153948002641 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 153948002642 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 153948002643 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 153948002644 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 153948002645 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 153948002646 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 153948002647 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 153948002648 Protein export membrane protein; Region: SecD_SecF; pfam02355 153948002649 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 153948002650 Integrase core domain; Region: rve; pfam00665 153948002651 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 153948002652 Cell division protein ZapA; Region: ZapA; pfam05164 153948002653 ZipA, C-terminal domain (FtsZ-binding); Region: ZipA_C; smart00771 153948002654 FtsZ protein binding site [polypeptide binding]; other site 153948002655 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 153948002656 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 153948002657 Walker A/P-loop; other site 153948002658 ATP binding site [chemical binding]; other site 153948002659 Q-loop/lid; other site 153948002660 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 153948002661 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 153948002662 ABC transporter signature motif; other site 153948002663 Walker B; other site 153948002664 D-loop; other site 153948002665 H-loop/switch region; other site 153948002666 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 153948002667 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 153948002668 N-acetyl-D-glucosamine binding site [chemical binding]; other site 153948002669 catalytic residue [active] 153948002670 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 153948002671 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 153948002672 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 153948002673 interface (dimer of trimers) [polypeptide binding]; other site 153948002674 Substrate-binding/catalytic site; other site 153948002675 Zn-binding sites [ion binding]; other site 153948002676 thymidylate synthase; Reviewed; Region: thyA; PRK01827 153948002677 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 153948002678 dimerization interface [polypeptide binding]; other site 153948002679 active site 153948002680 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 153948002681 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 153948002682 folate binding site [chemical binding]; other site 153948002683 NADP+ binding site [chemical binding]; other site 153948002684 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 153948002685 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 153948002686 active site 153948002687 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 153948002688 dimer interface [polypeptide binding]; other site 153948002689 catalytic residues [active] 153948002690 substrate binding site [chemical binding]; other site 153948002691 TIGR03790 family protein; Region: TIGR03790 153948002692 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 153948002693 trimer interface [polypeptide binding]; other site 153948002694 active site 153948002695 Domain of unknown function DUF59; Region: DUF59; pfam01883 153948002696 antiporter inner membrane protein; Provisional; Region: PRK11670 153948002697 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 153948002698 Walker A motif; other site 153948002699 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 153948002700 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 153948002701 active site 153948002702 HIGH motif; other site 153948002703 KMSKS motif; other site 153948002704 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 153948002705 tRNA binding surface [nucleotide binding]; other site 153948002706 anticodon binding site; other site 153948002707 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 153948002708 dimer interface [polypeptide binding]; other site 153948002709 putative tRNA-binding site [nucleotide binding]; other site 153948002710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 153948002711 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 153948002712 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 153948002713 catalytic residue [active] 153948002714 potential frameshift: common BLAST hit: gi|81300146|ref|YP_400354.1| Integrins alpha chain 153948002715 FG-GAP repeat; Region: FG-GAP; cl15299 153948002716 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 153948002717 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 153948002718 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 153948002719 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 153948002720 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 153948002721 putative active site [active] 153948002722 putative substrate binding site [chemical binding]; other site 153948002723 ATP binding site [chemical binding]; other site 153948002724 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 153948002725 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 153948002726 DNA polymerase I; Provisional; Region: PRK05755 153948002727 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 153948002728 active site 153948002729 metal binding site 1 [ion binding]; metal-binding site 153948002730 putative 5' ssDNA interaction site; other site 153948002731 metal binding site 3; metal-binding site 153948002732 metal binding site 2 [ion binding]; metal-binding site 153948002733 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 153948002734 putative DNA binding site [nucleotide binding]; other site 153948002735 putative metal binding site [ion binding]; other site 153948002736 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 153948002737 active site 153948002738 catalytic site [active] 153948002739 substrate binding site [chemical binding]; other site 153948002740 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 153948002741 active site 153948002742 DNA binding site [nucleotide binding] 153948002743 catalytic site [active] 153948002744 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 153948002745 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 153948002746 homodimer interface [polypeptide binding]; other site 153948002747 oligonucleotide binding site [chemical binding]; other site 153948002748 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 153948002749 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 153948002750 RNA binding surface [nucleotide binding]; other site 153948002751 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 153948002752 active site 153948002753 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 153948002754 active site 153948002755 catalytic triad [active] 153948002756 oxyanion hole [active] 153948002757 switch loop; other site 153948002758 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 153948002759 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 153948002760 Walker A/P-loop; other site 153948002761 ATP binding site [chemical binding]; other site 153948002762 Q-loop/lid; other site 153948002763 ABC transporter signature motif; other site 153948002764 Walker B; other site 153948002765 D-loop; other site 153948002766 H-loop/switch region; other site 153948002767 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 153948002768 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 153948002769 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 153948002770 FeS/SAM binding site; other site 153948002771 HemN C-terminal domain; Region: HemN_C; pfam06969 153948002772 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 153948002773 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 153948002774 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948002775 active site 153948002776 phosphorylation site [posttranslational modification] 153948002777 intermolecular recognition site; other site 153948002778 dimerization interface [polypeptide binding]; other site 153948002779 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 153948002780 DNA binding site [nucleotide binding] 153948002781 pyruvate carboxylase subunit B; Validated; Region: PRK09282 153948002782 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 153948002783 active site 153948002784 catalytic residues [active] 153948002785 metal binding site [ion binding]; metal-binding site 153948002786 homodimer binding site [polypeptide binding]; other site 153948002787 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 153948002788 carboxyltransferase (CT) interaction site; other site 153948002789 biotinylation site [posttranslational modification]; other site 153948002790 pyruvate carboxylase subunit A; Validated; Region: PRK07178 153948002791 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 153948002792 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 153948002793 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 153948002794 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 153948002795 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 153948002796 homodimer interface [polypeptide binding]; other site 153948002797 substrate-cofactor binding pocket; other site 153948002798 pyridoxal 5'-phosphate binding site [chemical binding]; other site 153948002799 catalytic residue [active] 153948002800 hypothetical protein; Provisional; Region: PRK01842 153948002801 SEC-C motif; Region: SEC-C; pfam02810 153948002802 DNA polymerase IV; Validated; Region: PRK03352 153948002803 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 153948002804 active site 153948002805 DNA binding site [nucleotide binding] 153948002806 CAAX prenyl protease-related protein; Region: pepcterm_CAAX; TIGR03008 153948002807 Flagellar protein YcgR; Region: YcgR_2; pfam12945 153948002808 PilZ domain; Region: PilZ; pfam07238 153948002809 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 153948002810 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 153948002811 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 153948002812 active site 153948002813 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 153948002814 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 153948002815 Ligand Binding Site [chemical binding]; other site 153948002816 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 153948002817 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 153948002818 FecR protein; Region: FecR; pfam04773 153948002819 Response regulator receiver domain; Region: Response_reg; pfam00072 153948002820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948002821 active site 153948002822 phosphorylation site [posttranslational modification] 153948002823 intermolecular recognition site; other site 153948002824 dimerization interface [polypeptide binding]; other site 153948002825 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948002826 Response regulator receiver domain; Region: Response_reg; pfam00072 153948002827 active site 153948002828 phosphorylation site [posttranslational modification] 153948002829 intermolecular recognition site; other site 153948002830 dimerization interface [polypeptide binding]; other site 153948002831 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 153948002832 prephenate dehydrogenase; Validated; Region: PRK08507 153948002833 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 153948002834 Transposase; Region: HTH_Tnp_1; cl17663 153948002835 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 153948002836 pyridoxal 5'-phosphate binding site [chemical binding]; other site 153948002837 homodimer interface [polypeptide binding]; other site 153948002838 catalytic residue [active] 153948002839 Chorismate mutase type II; Region: CM_2; cl00693 153948002840 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 153948002841 Prephenate dehydratase; Region: PDT; pfam00800 153948002842 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 153948002843 putative L-Phe binding site [chemical binding]; other site 153948002844 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 153948002845 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 153948002846 putative ligand binding site [chemical binding]; other site 153948002847 putative NAD binding site [chemical binding]; other site 153948002848 putative catalytic site [active] 153948002849 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 153948002850 ACT domain interface; other site 153948002851 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 153948002852 homodimer interface [polypeptide binding]; other site 153948002853 substrate-cofactor binding pocket; other site 153948002854 pyridoxal 5'-phosphate binding site [chemical binding]; other site 153948002855 catalytic residue [active] 153948002856 DNA gyrase subunit A; Validated; Region: PRK05560 153948002857 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 153948002858 CAP-like domain; other site 153948002859 active site 153948002860 primary dimer interface [polypeptide binding]; other site 153948002861 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 153948002862 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 153948002863 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 153948002864 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 153948002865 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 153948002866 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 153948002867 acetylornithine aminotransferase; Provisional; Region: PRK02627 153948002868 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 153948002869 inhibitor-cofactor binding pocket; inhibition site 153948002870 pyridoxal 5'-phosphate binding site [chemical binding]; other site 153948002871 catalytic residue [active] 153948002872 ornithine carbamoyltransferase; Provisional; Region: PRK00779 153948002873 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 153948002874 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 153948002875 argininosuccinate synthase; Provisional; Region: PRK13820 153948002876 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 153948002877 ANP binding site [chemical binding]; other site 153948002878 Substrate Binding Site II [chemical binding]; other site 153948002879 Substrate Binding Site I [chemical binding]; other site 153948002880 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 153948002881 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 153948002882 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 153948002883 S17 interaction site [polypeptide binding]; other site 153948002884 S8 interaction site; other site 153948002885 16S rRNA interaction site [nucleotide binding]; other site 153948002886 streptomycin interaction site [chemical binding]; other site 153948002887 23S rRNA interaction site [nucleotide binding]; other site 153948002888 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 153948002889 30S ribosomal protein S7; Validated; Region: PRK05302 153948002890 elongation factor G; Reviewed; Region: PRK00007 153948002891 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 153948002892 G1 box; other site 153948002893 putative GEF interaction site [polypeptide binding]; other site 153948002894 GTP/Mg2+ binding site [chemical binding]; other site 153948002895 Switch I region; other site 153948002896 G2 box; other site 153948002897 G3 box; other site 153948002898 Switch II region; other site 153948002899 G4 box; other site 153948002900 G5 box; other site 153948002901 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 153948002902 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 153948002903 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 153948002904 elongation factor Tu; Reviewed; Region: PRK00049 153948002905 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 153948002906 G1 box; other site 153948002907 GEF interaction site [polypeptide binding]; other site 153948002908 GTP/Mg2+ binding site [chemical binding]; other site 153948002909 Switch I region; other site 153948002910 G2 box; other site 153948002911 G3 box; other site 153948002912 Switch II region; other site 153948002913 G4 box; other site 153948002914 G5 box; other site 153948002915 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 153948002916 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 153948002917 Antibiotic Binding Site [chemical binding]; other site 153948002918 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 153948002919 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 153948002920 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 153948002921 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 153948002922 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 153948002923 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 153948002924 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 153948002925 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 153948002926 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 153948002927 protein-rRNA interface [nucleotide binding]; other site 153948002928 putative translocon binding site; other site 153948002929 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 153948002930 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 153948002931 G-X-X-G motif; other site 153948002932 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 153948002933 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 153948002934 23S rRNA interface [nucleotide binding]; other site 153948002935 5S rRNA interface [nucleotide binding]; other site 153948002936 putative antibiotic binding site [chemical binding]; other site 153948002937 L25 interface [polypeptide binding]; other site 153948002938 L27 interface [polypeptide binding]; other site 153948002939 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 153948002940 putative translocon interaction site; other site 153948002941 23S rRNA interface [nucleotide binding]; other site 153948002942 signal recognition particle (SRP54) interaction site; other site 153948002943 L23 interface [polypeptide binding]; other site 153948002944 trigger factor interaction site; other site 153948002945 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 153948002946 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 153948002947 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 153948002948 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 153948002949 RNA binding site [nucleotide binding]; other site 153948002950 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 153948002951 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 153948002952 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 153948002953 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 153948002954 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 153948002955 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 153948002956 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 153948002957 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 153948002958 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 153948002959 5S rRNA interface [nucleotide binding]; other site 153948002960 23S rRNA interface [nucleotide binding]; other site 153948002961 L5 interface [polypeptide binding]; other site 153948002962 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 153948002963 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 153948002964 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 153948002965 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 153948002966 23S rRNA binding site [nucleotide binding]; other site 153948002967 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 153948002968 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 153948002969 SecY translocase; Region: SecY; pfam00344 153948002970 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 153948002971 rRNA binding site [nucleotide binding]; other site 153948002972 predicted 30S ribosome binding site; other site 153948002973 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 153948002974 30S ribosomal protein S13; Region: bact_S13; TIGR03631 153948002975 30S ribosomal protein S11; Validated; Region: PRK05309 153948002976 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 153948002977 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 153948002978 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 153948002979 RNA binding surface [nucleotide binding]; other site 153948002980 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 153948002981 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 153948002982 alphaNTD homodimer interface [polypeptide binding]; other site 153948002983 alphaNTD - beta interaction site [polypeptide binding]; other site 153948002984 alphaNTD - beta' interaction site [polypeptide binding]; other site 153948002985 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 153948002986 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 153948002987 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 153948002988 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 153948002989 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 153948002990 Type III pantothenate kinase; Region: Pan_kinase; cl17198 153948002991 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 153948002992 G1 box; other site 153948002993 GTP/Mg2+ binding site [chemical binding]; other site 153948002994 Switch I region; other site 153948002995 G2 box; other site 153948002996 G3 box; other site 153948002997 Switch II region; other site 153948002998 G4 box; other site 153948002999 G5 box; other site 153948003000 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 153948003001 dimer interface [polypeptide binding]; other site 153948003002 active site 153948003003 aspartate-rich active site metal binding site; other site 153948003004 allosteric magnesium binding site [ion binding]; other site 153948003005 Schiff base residues; other site 153948003006 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 153948003007 Transglycosylase; Region: Transgly; pfam00912 153948003008 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 153948003009 Cell division protein FtsA; Region: FtsA; cl17206 153948003010 Competence protein A; Region: Competence_A; pfam11104 153948003011 Cell division protein FtsA; Region: FtsA; pfam14450 153948003012 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 153948003013 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 153948003014 Pilus assembly protein, PilO; Region: PilO; pfam04350 153948003015 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 153948003016 Pilus assembly protein, PilP; Region: PilP; pfam04351 153948003017 AMIN domain; Region: AMIN; pfam11741 153948003018 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 153948003019 Secretin and TonB N terminus short domain; Region: STN; smart00965 153948003020 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 153948003021 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 153948003022 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 153948003023 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 153948003024 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 153948003025 active site 153948003026 biotin synthase; Region: bioB; TIGR00433 153948003027 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 153948003028 FeS/SAM binding site; other site 153948003029 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 153948003030 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 153948003031 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 153948003032 substrate-cofactor binding pocket; other site 153948003033 pyridoxal 5'-phosphate binding site [chemical binding]; other site 153948003034 catalytic residue [active] 153948003035 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 153948003036 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 153948003037 TAP-like protein; Region: Abhydrolase_4; pfam08386 153948003038 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 153948003039 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 153948003040 S-adenosylmethionine binding site [chemical binding]; other site 153948003041 AAA domain; Region: AAA_26; pfam13500 153948003042 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 153948003043 Protein of unknown function (DUF3175); Region: DUF3175; pfam11373 153948003044 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 153948003045 active site clefts [active] 153948003046 zinc binding site [ion binding]; other site 153948003047 dimer interface [polypeptide binding]; other site 153948003048 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 153948003049 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 153948003050 homodimer interface [polypeptide binding]; other site 153948003051 active site 153948003052 TDP-binding site; other site 153948003053 acceptor substrate-binding pocket; other site 153948003054 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 153948003055 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 153948003056 potential catalytic triad [active] 153948003057 conserved cys residue [active] 153948003058 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 153948003059 EAL domain; Region: EAL; pfam00563 153948003060 CAAX protease self-immunity; Region: Abi; pfam02517 153948003061 CHRD domain; Region: CHRD; pfam07452 153948003062 Protein of unknown function, DUF393; Region: DUF393; pfam04134 153948003063 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 153948003064 Sodium Bile acid symporter family; Region: SBF; cl17470 153948003065 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 153948003066 chromosome condensation membrane protein; Provisional; Region: PRK14196 153948003067 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 153948003068 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 153948003069 transmembrane helices; other site 153948003070 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 153948003071 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 153948003072 TrkA-C domain; Region: TrkA_C; pfam02080 153948003073 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 153948003074 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 153948003075 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 153948003076 transmembrane helices; other site 153948003077 TrkA-C domain; Region: TrkA_C; pfam02080 153948003078 TrkA-C domain; Region: TrkA_C; pfam02080 153948003079 TrkA-C domain; Region: TrkA_C; pfam02080 153948003080 TrkA-C domain; Region: TrkA_C; pfam02080 153948003081 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 153948003082 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 153948003083 Transcriptional regulator [Transcription]; Region: LysR; COG0583 153948003084 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 153948003085 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 153948003086 putative effector binding pocket; other site 153948003087 dimerization interface [polypeptide binding]; other site 153948003088 sulfotransferase; Region: PLN02164 153948003089 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 153948003090 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 153948003091 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 153948003092 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 153948003093 Walker A motif; other site 153948003094 ATP binding site [chemical binding]; other site 153948003095 Walker B motif; other site 153948003096 arginine finger; other site 153948003097 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 153948003098 Membrane fusogenic activity; Region: BMFP; pfam04380 153948003099 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 153948003100 Phosphotransferase enzyme family; Region: APH; pfam01636 153948003101 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 153948003102 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 153948003103 Substrate binding site; other site 153948003104 metal-binding site 153948003105 proline aminopeptidase P II; Provisional; Region: PRK10879 153948003106 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 153948003107 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 153948003108 active site 153948003109 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 153948003110 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 153948003111 active site 153948003112 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 153948003113 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 153948003114 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 153948003115 FHIPEP family; Region: FHIPEP; pfam00771 153948003116 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14721 153948003117 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 153948003118 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 153948003119 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 153948003120 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 153948003121 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 153948003122 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 153948003123 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 153948003124 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 153948003125 DNA binding residues [nucleotide binding] 153948003126 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 153948003127 flagellar motor protein; Reviewed; Region: motC; PRK09109 153948003128 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 153948003129 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 153948003130 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 153948003131 ligand binding site [chemical binding]; other site 153948003132 FlgN protein; Region: FlgN; pfam05130 153948003133 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 153948003134 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 153948003135 Protein of unknown function (DUF3025); Region: DUF3025; pfam11227 153948003136 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 153948003137 active site 153948003138 multimer interface [polypeptide binding]; other site 153948003139 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 153948003140 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 153948003141 FeS/SAM binding site; other site 153948003142 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 153948003143 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 153948003144 binding surface 153948003145 TPR motif; other site 153948003146 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 153948003147 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 153948003148 non-specific DNA binding site [nucleotide binding]; other site 153948003149 salt bridge; other site 153948003150 sequence-specific DNA binding site [nucleotide binding]; other site 153948003151 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 153948003152 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 153948003153 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 153948003154 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 153948003155 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 153948003156 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 153948003157 dimer interface [polypeptide binding]; other site 153948003158 motif 1; other site 153948003159 active site 153948003160 motif 2; other site 153948003161 motif 3; other site 153948003162 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 153948003163 anticodon binding site; other site 153948003164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 153948003165 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 153948003166 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 153948003167 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 153948003168 Trp docking motif [polypeptide binding]; other site 153948003169 active site 153948003170 GTP-binding protein Der; Reviewed; Region: PRK00093 153948003171 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 153948003172 G1 box; other site 153948003173 GTP/Mg2+ binding site [chemical binding]; other site 153948003174 Switch I region; other site 153948003175 G2 box; other site 153948003176 Switch II region; other site 153948003177 G3 box; other site 153948003178 G4 box; other site 153948003179 G5 box; other site 153948003180 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 153948003181 G1 box; other site 153948003182 GTP/Mg2+ binding site [chemical binding]; other site 153948003183 Switch I region; other site 153948003184 G2 box; other site 153948003185 G3 box; other site 153948003186 Switch II region; other site 153948003187 G4 box; other site 153948003188 G5 box; other site 153948003189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948003190 active site 153948003191 phosphorylation site [posttranslational modification] 153948003192 intermolecular recognition site; other site 153948003193 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 153948003194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948003195 active site 153948003196 phosphorylation site [posttranslational modification] 153948003197 intermolecular recognition site; other site 153948003198 dimerization interface [polypeptide binding]; other site 153948003199 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 153948003200 DNA binding residues [nucleotide binding] 153948003201 dimerization interface [polypeptide binding]; other site 153948003202 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 153948003203 Transposase; Region: HTH_Tnp_1; pfam01527 153948003204 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 153948003205 Helix-turn-helix domain; Region: HTH_38; pfam13936 153948003206 Homeodomain-like domain; Region: HTH_32; pfam13565 153948003207 Integrase core domain; Region: rve; pfam00665 153948003208 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 153948003209 TIGR01777 family protein; Region: yfcH 153948003210 NAD(P) binding site [chemical binding]; other site 153948003211 active site 153948003212 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 153948003213 DNA photolyase; Region: DNA_photolyase; pfam00875 153948003214 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 153948003215 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 153948003216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948003217 active site 153948003218 phosphorylation site [posttranslational modification] 153948003219 intermolecular recognition site; other site 153948003220 dimerization interface [polypeptide binding]; other site 153948003221 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 153948003222 DNA binding site [nucleotide binding] 153948003223 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 153948003224 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 153948003225 dimer interface [polypeptide binding]; other site 153948003226 phosphorylation site [posttranslational modification] 153948003227 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 153948003228 ATP binding site [chemical binding]; other site 153948003229 Mg2+ binding site [ion binding]; other site 153948003230 G-X-G motif; other site 153948003231 Predicted membrane protein [Function unknown]; Region: COG2119 153948003232 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 153948003233 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 153948003234 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 153948003235 putative NAD(P) binding site [chemical binding]; other site 153948003236 putative substrate binding site [chemical binding]; other site 153948003237 catalytic Zn binding site [ion binding]; other site 153948003238 structural Zn binding site [ion binding]; other site 153948003239 dimer interface [polypeptide binding]; other site 153948003240 Predicted ATPase [General function prediction only]; Region: COG1485 153948003241 muropeptide transporter; Reviewed; Region: ampG; PRK11902 153948003242 AmpG-like permease; Region: 2A0125; TIGR00901 153948003243 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 153948003244 putative active site [active] 153948003245 putative catalytic site [active] 153948003246 putative DNA binding site [nucleotide binding]; other site 153948003247 putative phosphate binding site [ion binding]; other site 153948003248 metal binding site A [ion binding]; metal-binding site 153948003249 putative AP binding site [nucleotide binding]; other site 153948003250 putative metal binding site B [ion binding]; other site 153948003251 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 153948003252 active site 153948003253 HNH endonuclease; Region: HNH_2; pfam13391 153948003254 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 153948003255 active site 153948003256 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 153948003257 AAA domain; Region: AAA_21; pfam13304 153948003258 Walker A/P-loop; other site 153948003259 ATP binding site [chemical binding]; other site 153948003260 Protein of unknown function (DUF3696); Region: DUF3696; pfam12476 153948003261 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 153948003262 Helix-turn-helix domain; Region: HTH_38; pfam13936 153948003263 Homeodomain-like domain; Region: HTH_32; pfam13565 153948003264 Integrase core domain; Region: rve; pfam00665 153948003265 Transposase; Region: HTH_Tnp_1; cl17663 153948003266 Transposase; Region: HTH_Tnp_1; cl17663 153948003267 putative transposase OrfB; Reviewed; Region: PHA02517 153948003268 HTH-like domain; Region: HTH_21; pfam13276 153948003269 Integrase core domain; Region: rve; pfam00665 153948003270 Integrase core domain; Region: rve_3; cl15866 153948003271 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 153948003272 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 153948003273 ATP binding site [chemical binding]; other site 153948003274 putative Mg++ binding site [ion binding]; other site 153948003275 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 153948003276 Peptidase M15; Region: Peptidase_M15_3; cl01194 153948003277 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 153948003278 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 153948003279 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 153948003280 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 153948003281 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 153948003282 active site 153948003283 Isochorismatase family; Region: Isochorismatase; pfam00857 153948003284 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 153948003285 catalytic triad [active] 153948003286 dimer interface [polypeptide binding]; other site 153948003287 conserved cis-peptide bond; other site 153948003288 SnoaL-like domain; Region: SnoaL_2; pfam12680 153948003289 Pirin-related protein [General function prediction only]; Region: COG1741 153948003290 Pirin; Region: Pirin; pfam02678 153948003291 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 153948003292 Predicted transcriptional regulators [Transcription]; Region: COG1733 153948003293 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 153948003294 dimerization interface [polypeptide binding]; other site 153948003295 putative DNA binding site [nucleotide binding]; other site 153948003296 putative Zn2+ binding site [ion binding]; other site 153948003297 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 153948003298 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 153948003299 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 153948003300 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 153948003301 PEP-CTERM motif; Region: VPEP; pfam07589 153948003302 adenylosuccinate lyase; Provisional; Region: PRK09285 153948003303 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 153948003304 tetramer interface [polypeptide binding]; other site 153948003305 active site 153948003306 GrpE; Region: GrpE; pfam01025 153948003307 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 153948003308 dimer interface [polypeptide binding]; other site 153948003309 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 153948003310 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 153948003311 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 153948003312 nucleotide binding site [chemical binding]; other site 153948003313 chaperone protein DnaJ; Provisional; Region: PRK10767 153948003314 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 153948003315 HSP70 interaction site [polypeptide binding]; other site 153948003316 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 153948003317 substrate binding site [polypeptide binding]; other site 153948003318 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 153948003319 Zn binding sites [ion binding]; other site 153948003320 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 153948003321 dimer interface [polypeptide binding]; other site 153948003322 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 153948003323 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 153948003324 Competence protein; Region: Competence; pfam03772 153948003325 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 153948003326 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 153948003327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 153948003328 ATP binding site [chemical binding]; other site 153948003329 Mg2+ binding site [ion binding]; other site 153948003330 G-X-G motif; other site 153948003331 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 153948003332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948003333 active site 153948003334 phosphorylation site [posttranslational modification] 153948003335 intermolecular recognition site; other site 153948003336 dimerization interface [polypeptide binding]; other site 153948003337 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 153948003338 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 153948003339 dimerization interface [polypeptide binding]; other site 153948003340 domain crossover interface; other site 153948003341 redox-dependent activation switch; other site 153948003342 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 153948003343 PAS domain; Region: PAS_9; pfam13426 153948003344 putative active site [active] 153948003345 heme pocket [chemical binding]; other site 153948003346 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 153948003347 dimer interface [polypeptide binding]; other site 153948003348 phosphorylation site [posttranslational modification] 153948003349 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 153948003350 ATP binding site [chemical binding]; other site 153948003351 Mg2+ binding site [ion binding]; other site 153948003352 G-X-G motif; other site 153948003353 Response regulator receiver domain; Region: Response_reg; pfam00072 153948003354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948003355 active site 153948003356 phosphorylation site [posttranslational modification] 153948003357 intermolecular recognition site; other site 153948003358 dimerization interface [polypeptide binding]; other site 153948003359 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 153948003360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948003361 active site 153948003362 phosphorylation site [posttranslational modification] 153948003363 intermolecular recognition site; other site 153948003364 dimerization interface [polypeptide binding]; other site 153948003365 PAS domain S-box; Region: sensory_box; TIGR00229 153948003366 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 153948003367 putative active site [active] 153948003368 heme pocket [chemical binding]; other site 153948003369 Histidine kinase; Region: HisKA_3; pfam07730 153948003370 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 153948003371 Mg2+ binding site [ion binding]; other site 153948003372 G-X-G motif; other site 153948003373 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 153948003374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948003375 active site 153948003376 phosphorylation site [posttranslational modification] 153948003377 intermolecular recognition site; other site 153948003378 dimerization interface [polypeptide binding]; other site 153948003379 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 153948003380 DNA binding residues [nucleotide binding] 153948003381 dimerization interface [polypeptide binding]; other site 153948003382 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 153948003383 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 153948003384 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 153948003385 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 153948003386 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 153948003387 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 153948003388 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 153948003389 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 153948003390 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 153948003391 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 153948003392 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 153948003393 Cupin domain; Region: Cupin_2; pfam07883 153948003394 peptidyl-prolyl cis-trans isomerase, EpsD family; Region: cis_trans_EpsD; TIGR02925 153948003395 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 153948003396 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 153948003397 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 153948003398 SLBB domain; Region: SLBB; pfam10531 153948003399 chain length determinant protein EpsF; Region: EpsF; TIGR03017 153948003400 Chain length determinant protein; Region: Wzz; cl15801 153948003401 Chain length determinant protein; Region: Wzz; cl15801 153948003402 chain length determinant protein tyrosine kinase EpsG; Region: EpsG; TIGR03029 153948003403 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 153948003404 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 153948003405 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 153948003406 Protein of unknown function (DUF3485); Region: DUF3485; pfam11984 153948003407 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 153948003408 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 153948003409 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 153948003410 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 153948003411 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 153948003412 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 153948003413 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 153948003414 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 153948003415 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 153948003416 putative ADP-binding pocket [chemical binding]; other site 153948003417 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 153948003418 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 153948003419 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 153948003420 FOG: CBS domain [General function prediction only]; Region: COG0517 153948003421 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 153948003422 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 153948003423 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 153948003424 CoA binding domain; Region: CoA_binding; smart00881 153948003425 CoA-ligase; Region: Ligase_CoA; pfam00549 153948003426 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 153948003427 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 153948003428 CoA-ligase; Region: Ligase_CoA; pfam00549 153948003429 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 153948003430 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 153948003431 Hpt domain; Region: Hpt; pfam01627 153948003432 putative binding surface; other site 153948003433 active site 153948003434 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948003435 active site 153948003436 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 153948003437 phosphorylation site [posttranslational modification] 153948003438 intermolecular recognition site; other site 153948003439 dimerization interface [polypeptide binding]; other site 153948003440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948003441 active site 153948003442 phosphorylation site [posttranslational modification] 153948003443 intermolecular recognition site; other site 153948003444 dimerization interface [polypeptide binding]; other site 153948003445 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 153948003446 metal binding site [ion binding]; metal-binding site 153948003447 active site 153948003448 I-site; other site 153948003449 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 153948003450 Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400 153948003451 7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402 153948003452 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 153948003453 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 153948003454 E3 interaction surface; other site 153948003455 lipoyl attachment site [posttranslational modification]; other site 153948003456 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 153948003457 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 153948003458 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 153948003459 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 153948003460 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 153948003461 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 153948003462 putative catalytic cysteine [active] 153948003463 HDOD domain; Region: HDOD; pfam08668 153948003464 PEP-CTERM motif; Region: VPEP; pfam07589 153948003465 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 153948003466 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 153948003467 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 153948003468 putative homodimer interface [polypeptide binding]; other site 153948003469 putative active site pocket [active] 153948003470 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 153948003471 Glucokinase; Region: Glucokinase; pfam02685 153948003472 glucokinase, proteobacterial type; Region: glk; TIGR00749 153948003473 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 153948003474 Zonular occludens toxin (Zot); Region: Zot; cl17485 153948003475 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 153948003476 ATP-grasp domain; Region: ATP-grasp_4; cl17255 153948003477 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 153948003478 Coenzyme A binding pocket [chemical binding]; other site 153948003479 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 153948003480 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 153948003481 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 153948003482 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 153948003483 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 153948003484 HflX GTPase family; Region: HflX; cd01878 153948003485 G1 box; other site 153948003486 GTP/Mg2+ binding site [chemical binding]; other site 153948003487 Switch I region; other site 153948003488 G2 box; other site 153948003489 G3 box; other site 153948003490 Switch II region; other site 153948003491 G4 box; other site 153948003492 G5 box; other site 153948003493 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 153948003494 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 153948003495 Zn2+ binding site [ion binding]; other site 153948003496 Mg2+ binding site [ion binding]; other site 153948003497 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 153948003498 synthetase active site [active] 153948003499 NTP binding site [chemical binding]; other site 153948003500 metal binding site [ion binding]; metal-binding site 153948003501 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 153948003502 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 153948003503 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 153948003504 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 153948003505 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 153948003506 catalytic site [active] 153948003507 G-X2-G-X-G-K; other site 153948003508 HDOD domain; Region: HDOD; pfam08668 153948003509 GAF domain; Region: GAF_3; pfam13492 153948003510 methionine sulfoxide reductase A; Provisional; Region: PRK14054 153948003511 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 153948003512 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 153948003513 catalytic residues [active] 153948003514 hinge region; other site 153948003515 alpha helical domain; other site 153948003516 Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087 153948003517 Sporulation related domain; Region: SPOR; pfam05036 153948003518 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 153948003519 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 153948003520 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 153948003521 active site 153948003522 HIGH motif; other site 153948003523 nucleotide binding site [chemical binding]; other site 153948003524 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 153948003525 KMSK motif region; other site 153948003526 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 153948003527 tRNA binding surface [nucleotide binding]; other site 153948003528 anticodon binding site; other site 153948003529 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 153948003530 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 153948003531 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 153948003532 ribonuclease R; Region: RNase_R; TIGR02063 153948003533 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 153948003534 RNB domain; Region: RNB; pfam00773 153948003535 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 153948003536 RNA binding site [nucleotide binding]; other site 153948003537 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 153948003538 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 153948003539 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 153948003540 RNase E interface [polypeptide binding]; other site 153948003541 trimer interface [polypeptide binding]; other site 153948003542 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 153948003543 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 153948003544 RNase E interface [polypeptide binding]; other site 153948003545 trimer interface [polypeptide binding]; other site 153948003546 active site 153948003547 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 153948003548 putative nucleic acid binding region [nucleotide binding]; other site 153948003549 G-X-X-G motif; other site 153948003550 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 153948003551 RNA binding site [nucleotide binding]; other site 153948003552 domain interface; other site 153948003553 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 153948003554 16S/18S rRNA binding site [nucleotide binding]; other site 153948003555 S13e-L30e interaction site [polypeptide binding]; other site 153948003556 25S rRNA binding site [nucleotide binding]; other site 153948003557 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 153948003558 G1 box; other site 153948003559 GTP/Mg2+ binding site [chemical binding]; other site 153948003560 G2 box; other site 153948003561 Switch I region; other site 153948003562 G3 box; other site 153948003563 Switch II region; other site 153948003564 G4 box; other site 153948003565 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 153948003566 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 153948003567 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 153948003568 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 153948003569 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 153948003570 putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073 153948003571 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 153948003572 active site 153948003573 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 153948003574 Part of AAA domain; Region: AAA_19; pfam13245 153948003575 AAA domain; Region: AAA_12; pfam13087 153948003576 Family description; Region: UvrD_C_2; pfam13538 153948003577 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 153948003578 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 153948003579 BolA-like protein; Region: BolA; cl00386 153948003580 Transcriptional regulator [Transcription]; Region: LysR; COG0583 153948003581 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 153948003582 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 153948003583 putative effector binding pocket; other site 153948003584 dimerization interface [polypeptide binding]; other site 153948003585 dihydroxyacetone kinase; Provisional; Region: PRK14479 153948003586 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 153948003587 DAK2 domain; Region: Dak2; pfam02734 153948003588 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 153948003589 dimerization interface [polypeptide binding]; other site 153948003590 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 153948003591 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 153948003592 putative active site [active] 153948003593 heme pocket [chemical binding]; other site 153948003594 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 153948003595 dimer interface [polypeptide binding]; other site 153948003596 phosphorylation site [posttranslational modification] 153948003597 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 153948003598 ATP binding site [chemical binding]; other site 153948003599 Mg2+ binding site [ion binding]; other site 153948003600 G-X-G motif; other site 153948003601 Response regulator receiver domain; Region: Response_reg; pfam00072 153948003602 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948003603 active site 153948003604 phosphorylation site [posttranslational modification] 153948003605 intermolecular recognition site; other site 153948003606 dimerization interface [polypeptide binding]; other site 153948003607 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 153948003608 putative binding surface; other site 153948003609 active site 153948003610 exopolysaccharide biosynthesis operon protein EpsL; Region: EpsL; TIGR03014 153948003611 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 153948003612 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 153948003613 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 153948003614 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 153948003615 Ferredoxin [Energy production and conversion]; Region: COG1146 153948003616 4Fe-4S binding domain; Region: Fer4; cl02805 153948003617 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 153948003618 probable DNA repair protein; Region: TIGR03623 153948003619 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 153948003620 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 153948003621 Part of AAA domain; Region: AAA_19; pfam13245 153948003622 Family description; Region: UvrD_C_2; pfam13538 153948003623 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 153948003624 Ammonia monooxygenase/methane monooxygenase, subunit C; Region: AmoC; pfam04896 153948003625 methane monooxygenase/ammonia monooxygenase, subunit A; Region: CH4_NH3mon_ox_A; TIGR03080 153948003626 methane monooxygenase/ammonia monooxygenase, subunit B; Region: CH4_NH3mon_ox_B; TIGR03079 153948003627 Monooxygenase subunit B protein; Region: Monooxygenase_B; pfam04744 153948003628 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 153948003629 active site residue [active] 153948003630 Amino acid permease; Region: AA_permease_2; pfam13520 153948003631 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 153948003632 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 153948003633 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 153948003634 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 153948003635 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 153948003636 BON domain; Region: BON; pfam04972 153948003637 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 153948003638 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 153948003639 S-adenosylmethionine binding site [chemical binding]; other site 153948003640 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 153948003641 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 153948003642 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 153948003643 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 153948003644 ThiS interaction site; other site 153948003645 putative active site [active] 153948003646 tetramer interface [polypeptide binding]; other site 153948003647 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 153948003648 thiS-thiF/thiG interaction site; other site 153948003649 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 153948003650 active site 153948003651 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 153948003652 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861 153948003653 Fic family protein [Function unknown]; Region: COG3177 153948003654 Fic/DOC family; Region: Fic; pfam02661 153948003655 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 153948003656 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 153948003657 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 153948003658 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 153948003659 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 153948003660 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 153948003661 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 153948003662 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 153948003663 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 153948003664 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 153948003665 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 153948003666 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 153948003667 HlyD family secretion protein; Region: HlyD_3; pfam13437 153948003668 Domain of unknown function (DUF4202); Region: DUF4202; pfam13875 153948003669 putative transposase OrfB; Reviewed; Region: PHA02517 153948003670 HTH-like domain; Region: HTH_21; pfam13276 153948003671 Integrase core domain; Region: rve; pfam00665 153948003672 Integrase core domain; Region: rve_3; cl15866 153948003673 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 153948003674 Helix-turn-helix domain; Region: HTH_38; pfam13936 153948003675 Homeodomain-like domain; Region: HTH_32; pfam13565 153948003676 Integrase core domain; Region: rve; pfam00665 153948003677 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 153948003678 Integrase core domain; Region: rve; pfam00665 153948003679 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 153948003680 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 153948003681 Multicopper oxidase; Region: Cu-oxidase; pfam00394 153948003682 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 153948003683 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 153948003684 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 153948003685 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 153948003686 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 153948003687 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 153948003688 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 153948003689 active site 153948003690 DNA binding site [nucleotide binding] 153948003691 Int/Topo IB signature motif; other site 153948003692 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 153948003693 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 153948003694 phosphoglycolate phosphatase; Provisional; Region: PRK13222 153948003695 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 153948003696 motif II; other site 153948003697 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 153948003698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 153948003699 S-adenosylmethionine binding site [chemical binding]; other site 153948003700 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 153948003701 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 153948003702 active site 153948003703 putative substrate binding pocket [chemical binding]; other site 153948003704 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 153948003705 ligand binding site [chemical binding]; other site 153948003706 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 153948003707 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 153948003708 Walker A/P-loop; other site 153948003709 ATP binding site [chemical binding]; other site 153948003710 Q-loop/lid; other site 153948003711 ABC transporter signature motif; other site 153948003712 Walker B; other site 153948003713 D-loop; other site 153948003714 H-loop/switch region; other site 153948003715 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 153948003716 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 153948003717 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 153948003718 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 153948003719 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 153948003720 DNA binding site [nucleotide binding] 153948003721 catalytic residue [active] 153948003722 H2TH interface [polypeptide binding]; other site 153948003723 putative catalytic residues [active] 153948003724 turnover-facilitating residue; other site 153948003725 intercalation triad [nucleotide binding]; other site 153948003726 8OG recognition residue [nucleotide binding]; other site 153948003727 putative reading head residues; other site 153948003728 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 153948003729 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 153948003730 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 153948003731 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 153948003732 YGGT family; Region: YGGT; pfam02325 153948003733 YGGT family; Region: YGGT; pfam02325 153948003734 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 153948003735 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 153948003736 catalytic core [active] 153948003737 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 153948003738 pseudouridine synthase; Region: TIGR00093 153948003739 active site 153948003740 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 153948003741 Fatty acid desaturase; Region: FA_desaturase; pfam00487 153948003742 putative di-iron ligands [ion binding]; other site 153948003743 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 153948003744 Transposase; Region: DDE_Tnp_ISL3; pfam01610 153948003745 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 153948003746 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 153948003747 hypothetical protein; Reviewed; Region: PRK00024 153948003748 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 153948003749 MPN+ (JAMM) motif; other site 153948003750 Zinc-binding site [ion binding]; other site 153948003751 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 153948003752 Flavoprotein; Region: Flavoprotein; pfam02441 153948003753 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 153948003754 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 153948003755 trimer interface [polypeptide binding]; other site 153948003756 active site 153948003757 signal recognition particle protein; Provisional; Region: PRK10867 153948003758 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 153948003759 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 153948003760 P loop; other site 153948003761 GTP binding site [chemical binding]; other site 153948003762 Signal peptide binding domain; Region: SRP_SPB; pfam02978 153948003763 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 153948003764 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 153948003765 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 153948003766 CRISPR-associated protein Cas4; Region: cas4; TIGR00372 153948003767 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 153948003768 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 153948003769 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 153948003770 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 153948003771 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 153948003772 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 153948003773 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 153948003774 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 153948003775 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 153948003776 putative active site [active] 153948003777 putative PHP Thumb interface [polypeptide binding]; other site 153948003778 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 153948003779 generic binding surface II; other site 153948003780 generic binding surface I; other site 153948003781 putative protease; Provisional; Region: PRK15452 153948003782 Peptidase family U32; Region: Peptidase_U32; pfam01136 153948003783 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 153948003784 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 153948003785 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 153948003786 Walker A motif; other site 153948003787 ATP binding site [chemical binding]; other site 153948003788 Walker B motif; other site 153948003789 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 153948003790 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 153948003791 ligand binding site [chemical binding]; other site 153948003792 Transmembrane secretion effector; Region: MFS_3; pfam05977 153948003793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 153948003794 putative substrate translocation pore; other site 153948003795 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 153948003796 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 153948003797 active site 153948003798 zinc binding site [ion binding]; other site 153948003799 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 153948003800 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 153948003801 active site 153948003802 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 153948003803 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 153948003804 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 153948003805 acyl-activating enzyme (AAE) consensus motif; other site 153948003806 putative AMP binding site [chemical binding]; other site 153948003807 putative active site [active] 153948003808 putative CoA binding site [chemical binding]; other site 153948003809 hypothetical protein; Provisional; Region: PRK11295 153948003810 Y-family of DNA polymerases; Region: PolY; cl12025 153948003811 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 153948003812 catalytic core [active] 153948003813 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 153948003814 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 153948003815 polyphosphate kinase; Provisional; Region: PRK05443 153948003816 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 153948003817 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 153948003818 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 153948003819 putative domain interface [polypeptide binding]; other site 153948003820 putative active site [active] 153948003821 catalytic site [active] 153948003822 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 153948003823 putative active site [active] 153948003824 putative domain interface [polypeptide binding]; other site 153948003825 catalytic site [active] 153948003826 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 153948003827 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 153948003828 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 153948003829 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 153948003830 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 153948003831 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 153948003832 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 153948003833 N-terminal plug; other site 153948003834 ligand-binding site [chemical binding]; other site 153948003835 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 153948003836 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 153948003837 Transposase domain (DUF772); Region: DUF772; pfam05598 153948003838 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 153948003839 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 153948003840 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 153948003841 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 153948003842 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 153948003843 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 153948003844 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 153948003845 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 153948003846 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 153948003847 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 153948003848 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 153948003849 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 153948003850 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 153948003851 AAA domain; Region: AAA_33; pfam13671 153948003852 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 153948003853 DNA methylase; Region: N6_N4_Mtase; pfam01555 153948003854 DNA methylase; Region: N6_N4_Mtase; pfam01555 153948003855 transposase/IS protein; Provisional; Region: PRK09183 153948003856 Putative ATP-dependent Lon protease; Region: Lon_2; cl11979 153948003857 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 153948003858 Walker A motif; other site 153948003859 ATP binding site [chemical binding]; other site 153948003860 Walker B motif; other site 153948003861 arginine finger; other site 153948003862 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 153948003863 Helix-turn-helix domain; Region: HTH_38; pfam13936 153948003864 Integrase core domain; Region: rve; pfam00665 153948003865 KilA-N domain; Region: KilA-N; pfam04383 153948003866 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 153948003867 ATP binding site [chemical binding]; other site 153948003868 putative Mg++ binding site [ion binding]; other site 153948003869 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 153948003870 nucleotide binding region [chemical binding]; other site 153948003871 ATP-binding site [chemical binding]; other site 153948003872 aspartate kinase; Reviewed; Region: PRK06635 153948003873 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 153948003874 putative nucleotide binding site [chemical binding]; other site 153948003875 putative catalytic residues [active] 153948003876 putative Mg ion binding site [ion binding]; other site 153948003877 putative aspartate binding site [chemical binding]; other site 153948003878 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 153948003879 putative allosteric regulatory site; other site 153948003880 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 153948003881 putative allosteric regulatory residue; other site 153948003882 tetraacyldisaccharide 4'-kinase; Provisional; Region: PRK01906 153948003883 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 153948003884 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 153948003885 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 153948003886 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 153948003887 FeS/SAM binding site; other site 153948003888 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 153948003889 active site 153948003890 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 153948003891 active site 153948003892 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 153948003893 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 153948003894 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 153948003895 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 153948003896 short chain dehydrogenase; Provisional; Region: PRK12939 153948003897 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 153948003898 NADP binding site [chemical binding]; other site 153948003899 homodimer interface [polypeptide binding]; other site 153948003900 active site 153948003901 substrate binding site [chemical binding]; other site 153948003902 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 153948003903 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 153948003904 hexamer interface [polypeptide binding]; other site 153948003905 ligand binding site [chemical binding]; other site 153948003906 putative active site [active] 153948003907 NAD(P) binding site [chemical binding]; other site 153948003908 Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934 153948003909 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 153948003910 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 153948003911 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 153948003912 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 153948003913 catalytic residues [active] 153948003914 Domain of unknown function (DUF4266); Region: DUF4266; pfam14086 153948003915 Protein of unknown function (DUF3570); Region: DUF3570; pfam12094 153948003916 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 153948003917 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 153948003918 ApbE family; Region: ApbE; pfam02424 153948003919 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 153948003920 nucleophilic elbow; other site 153948003921 catalytic triad; other site 153948003922 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 153948003923 putative ligand binding pocket/active site [active] 153948003924 putative metal binding site [ion binding]; other site 153948003925 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 153948003926 AMMECR1; Region: AMMECR1; pfam01871 153948003927 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 153948003928 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 153948003929 FeS/SAM binding site; other site 153948003930 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 153948003931 FOG: CBS domain [General function prediction only]; Region: COG0517 153948003932 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 153948003933 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 153948003934 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 153948003935 Flagellar transcriptional activator (FlhD); Region: FlhD; pfam05247 153948003936 Flagellar transcriptional activator (FlhC); Region: FlhC; pfam05280 153948003937 aspartate aminotransferase; Provisional; Region: PRK05764 153948003938 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 153948003939 pyridoxal 5'-phosphate binding site [chemical binding]; other site 153948003940 homodimer interface [polypeptide binding]; other site 153948003941 catalytic residue [active] 153948003942 excinuclease ABC subunit B; Provisional; Region: PRK05298 153948003943 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 153948003944 ATP binding site [chemical binding]; other site 153948003945 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 153948003946 nucleotide binding region [chemical binding]; other site 153948003947 ATP-binding site [chemical binding]; other site 153948003948 Ultra-violet resistance protein B; Region: UvrB; pfam12344 153948003949 UvrB/uvrC motif; Region: UVR; pfam02151 153948003950 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 153948003951 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 153948003952 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 153948003953 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 153948003954 NAD binding site [chemical binding]; other site 153948003955 dimerization interface [polypeptide binding]; other site 153948003956 product binding site; other site 153948003957 substrate binding site [chemical binding]; other site 153948003958 zinc binding site [ion binding]; other site 153948003959 catalytic residues [active] 153948003960 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 153948003961 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 153948003962 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 153948003963 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 153948003964 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 153948003965 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 153948003966 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 153948003967 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 153948003968 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 153948003969 XdhC Rossmann domain; Region: XdhC_C; pfam13478 153948003970 ATP-grasp domain; Region: ATP-grasp; pfam02222 153948003971 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 153948003972 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 153948003973 ATP binding site [chemical binding]; other site 153948003974 active site 153948003975 substrate binding site [chemical binding]; other site 153948003976 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 153948003977 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 153948003978 putative NAD(P) binding site [chemical binding]; other site 153948003979 Protein of unknown function (DUF465); Region: DUF465; cl01070 153948003980 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 153948003981 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 153948003982 Walker A/P-loop; other site 153948003983 ATP binding site [chemical binding]; other site 153948003984 Q-loop/lid; other site 153948003985 ABC transporter signature motif; other site 153948003986 Walker B; other site 153948003987 D-loop; other site 153948003988 H-loop/switch region; other site 153948003989 CcmB protein; Region: CcmB; pfam03379 153948003990 heme exporter protein CcmC; Region: ccmC; TIGR01191 153948003991 heme exporter protein CcmD; Region: cytochro_ccmD; TIGR03141 153948003992 CcmE; Region: CcmE; pfam03100 153948003993 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 153948003994 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 153948003995 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 153948003996 catalytic residues [active] 153948003997 central insert; other site 153948003998 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 153948003999 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 153948004000 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 153948004001 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 153948004002 binding surface 153948004003 TPR motif; other site 153948004004 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 153948004005 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 153948004006 catalytic triad [active] 153948004007 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 153948004008 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 153948004009 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 153948004010 homodimer interface [polypeptide binding]; other site 153948004011 Walker A motif; other site 153948004012 ATP binding site [chemical binding]; other site 153948004013 hydroxycobalamin binding site [chemical binding]; other site 153948004014 Walker B motif; other site 153948004015 TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779 153948004016 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 153948004017 N-terminal plug; other site 153948004018 ligand-binding site [chemical binding]; other site 153948004019 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 153948004020 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_6; cd06256 153948004021 putative active site [active] 153948004022 Zn binding site [ion binding]; other site 153948004023 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 153948004024 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 153948004025 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 153948004026 putative hydrolase; Provisional; Region: PRK11460 153948004027 S-adenosylmethionine synthetase; Validated; Region: PRK05250 153948004028 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 153948004029 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 153948004030 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 153948004031 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 153948004032 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 153948004033 homotetramer interface [polypeptide binding]; other site 153948004034 ligand binding site [chemical binding]; other site 153948004035 catalytic site [active] 153948004036 NAD binding site [chemical binding]; other site 153948004037 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 153948004038 FAD binding site [chemical binding]; other site 153948004039 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189 153948004040 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 153948004041 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 153948004042 homodimer interface [polypeptide binding]; other site 153948004043 NADP binding site [chemical binding]; other site 153948004044 substrate binding site [chemical binding]; other site 153948004045 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 153948004046 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 153948004047 dimer interface [polypeptide binding]; other site 153948004048 TPP-binding site [chemical binding]; other site 153948004049 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 153948004050 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 153948004051 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 153948004052 E3 interaction surface; other site 153948004053 lipoyl attachment site [posttranslational modification]; other site 153948004054 e3 binding domain; Region: E3_binding; pfam02817 153948004055 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 153948004056 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 153948004057 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 153948004058 active site 153948004059 (T/H)XGH motif; other site 153948004060 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 153948004061 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 153948004062 Maf-like protein; Region: Maf; pfam02545 153948004063 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 153948004064 active site 153948004065 dimer interface [polypeptide binding]; other site 153948004066 ribonuclease G; Provisional; Region: PRK11712 153948004067 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 153948004068 homodimer interface [polypeptide binding]; other site 153948004069 oligonucleotide binding site [chemical binding]; other site 153948004070 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 153948004071 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 153948004072 dimer interface [polypeptide binding]; other site 153948004073 active site 153948004074 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 153948004075 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 153948004076 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 153948004077 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 153948004078 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 153948004079 SelR domain; Region: SelR; pfam01641 153948004080 Putative motility protein; Region: YjfB_motility; pfam14070 153948004081 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 153948004082 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 153948004083 metal binding site [ion binding]; metal-binding site 153948004084 active site 153948004085 I-site; other site 153948004086 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 153948004087 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 153948004088 CoenzymeA binding site [chemical binding]; other site 153948004089 subunit interaction site [polypeptide binding]; other site 153948004090 PHB binding site; other site 153948004091 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 153948004092 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 153948004093 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 153948004094 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 153948004095 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 153948004096 Secretin and TonB N terminus short domain; Region: STN; smart00965 153948004097 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 153948004098 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 153948004099 N-terminal plug; other site 153948004100 ligand-binding site [chemical binding]; other site 153948004101 AlkA N-terminal domain; Region: AlkA_N; cl05528 153948004102 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 153948004103 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 153948004104 minor groove reading motif; other site 153948004105 helix-hairpin-helix signature motif; other site 153948004106 substrate binding pocket [chemical binding]; other site 153948004107 active site 153948004108 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 153948004109 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 153948004110 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 153948004111 DNA binding site [nucleotide binding] 153948004112 active site 153948004113 Transcriptional regulator [Transcription]; Region: LysR; COG0583 153948004114 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 153948004115 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 153948004116 dimerization interface [polypeptide binding]; other site 153948004117 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 153948004118 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 153948004119 THF binding site; other site 153948004120 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 153948004121 substrate binding site [chemical binding]; other site 153948004122 THF binding site; other site 153948004123 zinc-binding site [ion binding]; other site 153948004124 putative folate metabolism protein, CADD family; Region: fol_rel_CADD; TIGR04305 153948004125 aminotransferase AlaT; Validated; Region: PRK09265 153948004126 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 153948004127 pyridoxal 5'-phosphate binding site [chemical binding]; other site 153948004128 homodimer interface [polypeptide binding]; other site 153948004129 catalytic residue [active] 153948004130 homoserine dehydrogenase; Provisional; Region: PRK06349 153948004131 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 153948004132 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 153948004133 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 153948004134 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 153948004135 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 153948004136 pyridoxal 5'-phosphate binding site [chemical binding]; other site 153948004137 catalytic residue [active] 153948004138 Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023 153948004139 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 153948004140 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 153948004141 probable active site [active] 153948004142 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 153948004143 hypothetical protein; Validated; Region: PRK00153 153948004144 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14969 153948004145 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 153948004146 Walker A motif; other site 153948004147 ATP binding site [chemical binding]; other site 153948004148 Walker B motif; other site 153948004149 arginine finger; other site 153948004150 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 153948004151 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 153948004152 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 153948004153 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 153948004154 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 153948004155 Substrate binding site; other site 153948004156 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 153948004157 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 153948004158 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 153948004159 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 153948004160 amphipathic channel; other site 153948004161 Asn-Pro-Ala signature motifs; other site 153948004162 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 153948004163 dimerization interface [polypeptide binding]; other site 153948004164 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 153948004165 dimer interface [polypeptide binding]; other site 153948004166 conserved gate region; other site 153948004167 putative PBP binding loops; other site 153948004168 ABC-ATPase subunit interface; other site 153948004169 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 153948004170 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 153948004171 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 153948004172 Walker A/P-loop; other site 153948004173 ATP binding site [chemical binding]; other site 153948004174 Q-loop/lid; other site 153948004175 ABC transporter signature motif; other site 153948004176 Walker B; other site 153948004177 D-loop; other site 153948004178 H-loop/switch region; other site 153948004179 Uncharacterized conserved protein [Function unknown]; Region: COG0398 153948004180 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 153948004181 mercuric reductase; Validated; Region: PRK06370 153948004182 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 153948004183 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 153948004184 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 153948004185 Transposase; Region: HTH_Tnp_1; cl17663 153948004186 putative transposase OrfB; Reviewed; Region: PHA02517 153948004187 HTH-like domain; Region: HTH_21; pfam13276 153948004188 Integrase core domain; Region: rve; pfam00665 153948004189 Integrase core domain; Region: rve_3; cl15866 153948004190 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 153948004191 Integrase core domain; Region: rve; pfam00665 153948004192 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 153948004193 Zonular occludens toxin (Zot); Region: Zot; cl17485 153948004194 AAA domain; Region: AAA_22; pfam13401 153948004195 Protein of unknown function (DUF2523); Region: DUF2523; pfam10734 153948004196 phage/plasmid replication protein, gene II/X family; Region: rep_II_X; TIGR01629 153948004197 Phage replication protein CRI; Region: Phage_CRI; pfam05144 153948004198 Phage X family; Region: Phage_X; cl11585 153948004199 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 153948004200 Zonular occludens toxin (Zot); Region: Zot; cl17485 153948004201 Protein of unknown function (DUF2523); Region: DUF2523; pfam10734 153948004202 phage/plasmid replication protein, gene II/X family; Region: rep_II_X; TIGR01629 153948004203 Phage replication protein CRI; Region: Phage_CRI; pfam05144 153948004204 Phage X family; Region: Phage_X; cl11585 153948004205 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 153948004206 Predicted regulator of amino acid metabolism, contains ACT domain [General function prediction only]; Region: COG2150 153948004207 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 153948004208 Integrase core domain; Region: rve; pfam00665 153948004209 transposase/IS protein; Provisional; Region: PRK09183 153948004210 IstB-like ATP binding protein; Region: IstB_IS21; pfam01695 153948004211 ATP binding site [chemical binding]; other site 153948004212 Walker B motif; other site 153948004213 arginine finger; other site 153948004214 NlpC/P60 family; Region: NLPC_P60; pfam00877 153948004215 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 153948004216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948004217 active site 153948004218 phosphorylation site [posttranslational modification] 153948004219 intermolecular recognition site; other site 153948004220 dimerization interface [polypeptide binding]; other site 153948004221 CheB methylesterase; Region: CheB_methylest; pfam01339 153948004222 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13487 153948004223 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 153948004224 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 153948004225 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 153948004226 chemotaxis protein CheA; Provisional; Region: PRK10547 153948004227 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 153948004228 putative binding surface; other site 153948004229 active site 153948004230 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 153948004231 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 153948004232 ATP binding site [chemical binding]; other site 153948004233 Mg2+ binding site [ion binding]; other site 153948004234 G-X-G motif; other site 153948004235 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 153948004236 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 153948004237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948004238 active site 153948004239 phosphorylation site [posttranslational modification] 153948004240 intermolecular recognition site; other site 153948004241 dimerization interface [polypeptide binding]; other site 153948004242 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 153948004243 EAL domain; Region: EAL; pfam00563 153948004244 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 153948004245 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 153948004246 metal binding site [ion binding]; metal-binding site 153948004247 active site 153948004248 I-site; other site 153948004249 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 153948004250 EVE domain; Region: EVE; cl00728 153948004251 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 153948004252 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 153948004253 dimer interface [polypeptide binding]; other site 153948004254 substrate binding site [chemical binding]; other site 153948004255 metal binding sites [ion binding]; metal-binding site 153948004256 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 153948004257 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 153948004258 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 153948004259 ligand binding site [chemical binding]; other site 153948004260 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 153948004261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 153948004262 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 153948004263 ABC1 family; Region: ABC1; pfam03109 153948004264 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 153948004265 active site 153948004266 ATP binding site [chemical binding]; other site 153948004267 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 153948004268 dimer interface [polypeptide binding]; other site 153948004269 [2Fe-2S] cluster binding site [ion binding]; other site 153948004270 transcription termination factor Rho; Provisional; Region: rho; PRK09376 153948004271 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 153948004272 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 153948004273 RNA binding site [nucleotide binding]; other site 153948004274 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 153948004275 multimer interface [polypeptide binding]; other site 153948004276 Walker A motif; other site 153948004277 ATP binding site [chemical binding]; other site 153948004278 Walker B motif; other site 153948004279 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 153948004280 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 153948004281 catalytic residues [active] 153948004282 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 153948004283 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 153948004284 Walker A/P-loop; other site 153948004285 ATP binding site [chemical binding]; other site 153948004286 Q-loop/lid; other site 153948004287 ABC transporter signature motif; other site 153948004288 Walker B; other site 153948004289 D-loop; other site 153948004290 H-loop/switch region; other site 153948004291 TOBE domain; Region: TOBE_2; pfam08402 153948004292 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 153948004293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 153948004294 dimer interface [polypeptide binding]; other site 153948004295 conserved gate region; other site 153948004296 putative PBP binding loops; other site 153948004297 ABC-ATPase subunit interface; other site 153948004298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 153948004299 dimer interface [polypeptide binding]; other site 153948004300 conserved gate region; other site 153948004301 putative PBP binding loops; other site 153948004302 ABC-ATPase subunit interface; other site 153948004303 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 153948004304 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 153948004305 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 153948004306 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 153948004307 GTP/Mg2+ binding site [chemical binding]; other site 153948004308 G5 box; other site 153948004309 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 153948004310 Dynamin family; Region: Dynamin_N; pfam00350 153948004311 G1 box; other site 153948004312 G1 box; other site 153948004313 GTP/Mg2+ binding site [chemical binding]; other site 153948004314 Switch I region; other site 153948004315 G2 box; other site 153948004316 G2 box; other site 153948004317 Switch I region; other site 153948004318 G3 box; other site 153948004319 G3 box; other site 153948004320 Switch II region; other site 153948004321 Switch II region; other site 153948004322 G4 box; other site 153948004323 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 153948004324 G1 box; other site 153948004325 GTP/Mg2+ binding site [chemical binding]; other site 153948004326 G2 box; other site 153948004327 Switch I region; other site 153948004328 G3 box; other site 153948004329 Switch II region; other site 153948004330 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 153948004331 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 153948004332 Phage Tail Collar Domain; Region: Collar; pfam07484 153948004333 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 153948004334 Sel1-like repeats; Region: SEL1; smart00671 153948004335 flagellin; Validated; Region: PRK08026 153948004336 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 153948004337 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 153948004338 Mg++ binding site [ion binding]; other site 153948004339 putative catalytic motif [active] 153948004340 substrate binding site [chemical binding]; other site 153948004341 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941 153948004342 polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006 153948004343 putative active site [active] 153948004344 putative catalytic site [active] 153948004345 Glycerophosphodiester phosphodiesterase domain similar to Escherichia coli periplasmic phosphodiesterase (GlpQ) include uncharacterized proteins; Region: GDPD_EcGlpQ_like_1; cd08560 153948004346 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 153948004347 putative active site [active] 153948004348 catalytic site [active] 153948004349 putative metal binding site [ion binding]; other site 153948004350 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 153948004351 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 153948004352 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 153948004353 nucleophilic elbow; other site 153948004354 catalytic triad; other site 153948004355 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 153948004356 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 153948004357 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 153948004358 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 153948004359 S-adenosylmethionine binding site [chemical binding]; other site 153948004360 C factor cell-cell signaling protein; Provisional; Region: PRK09009 153948004361 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 153948004362 NADP binding site [chemical binding]; other site 153948004363 homodimer interface [polypeptide binding]; other site 153948004364 active site 153948004365 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 153948004366 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 153948004367 ABC-ATPase subunit interface; other site 153948004368 dimer interface [polypeptide binding]; other site 153948004369 putative PBP binding regions; other site 153948004370 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 153948004371 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 153948004372 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 153948004373 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 153948004374 intersubunit interface [polypeptide binding]; other site 153948004375 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 153948004376 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 153948004377 nickel responsive regulator; Provisional; Region: PRK02967 153948004378 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 153948004379 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 153948004380 Urea transporter; Region: UT; cl01829 153948004381 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 153948004382 G1 box; other site 153948004383 GTP/Mg2+ binding site [chemical binding]; other site 153948004384 G2 box; other site 153948004385 Switch I region; other site 153948004386 G3 box; other site 153948004387 Switch II region; other site 153948004388 G4 box; other site 153948004389 G5 box; other site 153948004390 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 153948004391 UreF; Region: UreF; pfam01730 153948004392 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 153948004393 dimer interface [polypeptide binding]; other site 153948004394 catalytic residues [active] 153948004395 urease subunit alpha; Reviewed; Region: ureC; PRK13207 153948004396 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 153948004397 subunit interactions [polypeptide binding]; other site 153948004398 active site 153948004399 flap region; other site 153948004400 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 153948004401 gamma-beta subunit interface [polypeptide binding]; other site 153948004402 alpha-beta subunit interface [polypeptide binding]; other site 153948004403 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 153948004404 alpha-gamma subunit interface [polypeptide binding]; other site 153948004405 beta-gamma subunit interface [polypeptide binding]; other site 153948004406 UreD urease accessory protein; Region: UreD; pfam01774 153948004407 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 153948004408 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 153948004409 putative active site; other site 153948004410 catalytic residue [active] 153948004411 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 153948004412 Sel1-like repeats; Region: SEL1; smart00671 153948004413 Sel1-like repeats; Region: SEL1; smart00671 153948004414 Sel1-like repeats; Region: SEL1; smart00671 153948004415 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 153948004416 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 153948004417 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 153948004418 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 153948004419 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 153948004420 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 153948004421 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 153948004422 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 153948004423 FMN binding site [chemical binding]; other site 153948004424 active site 153948004425 catalytic residues [active] 153948004426 substrate binding site [chemical binding]; other site 153948004427 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 153948004428 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 153948004429 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 153948004430 purine monophosphate binding site [chemical binding]; other site 153948004431 dimer interface [polypeptide binding]; other site 153948004432 putative catalytic residues [active] 153948004433 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 153948004434 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 153948004435 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 153948004436 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 153948004437 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 153948004438 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 153948004439 Transposase domain (DUF772); Region: DUF772; pfam05598 153948004440 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 153948004441 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 153948004442 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945 153948004443 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 153948004444 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 153948004445 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 153948004446 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 153948004447 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 153948004448 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 153948004449 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 153948004450 Flagellar L-ring protein; Region: FlgH; cl17277 153948004451 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 153948004452 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 153948004453 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 153948004454 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 153948004455 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 153948004456 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 153948004457 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 153948004458 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 153948004459 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 153948004460 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 153948004461 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 153948004462 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 153948004463 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 153948004464 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 153948004465 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 153948004466 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 153948004467 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 153948004468 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 153948004469 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 153948004470 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 153948004471 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 153948004472 acyl carrier protein; Provisional; Region: PRK07639 153948004473 Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560 153948004474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 153948004475 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 153948004476 Response regulator receiver domain; Region: Response_reg; pfam00072 153948004477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948004478 active site 153948004479 phosphorylation site [posttranslational modification] 153948004480 intermolecular recognition site; other site 153948004481 dimerization interface [polypeptide binding]; other site 153948004482 PAS domain; Region: PAS_9; pfam13426 153948004483 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 153948004484 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 153948004485 metal binding site [ion binding]; metal-binding site 153948004486 active site 153948004487 I-site; other site 153948004488 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 153948004489 PAS domain S-box; Region: sensory_box; TIGR00229 153948004490 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 153948004491 putative active site [active] 153948004492 heme pocket [chemical binding]; other site 153948004493 PAS domain S-box; Region: sensory_box; TIGR00229 153948004494 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 153948004495 putative active site [active] 153948004496 heme pocket [chemical binding]; other site 153948004497 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 153948004498 Histidine kinase; Region: HisKA_2; pfam07568 153948004499 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 153948004500 ATP binding site [chemical binding]; other site 153948004501 Mg2+ binding site [ion binding]; other site 153948004502 G-X-G motif; other site 153948004503 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 153948004504 TolR protein; Region: tolR; TIGR02801 153948004505 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 153948004506 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 153948004507 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 153948004508 RDD family; Region: RDD; pfam06271 153948004509 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 153948004510 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 153948004511 metal binding site [ion binding]; metal-binding site 153948004512 active site 153948004513 I-site; other site 153948004514 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 153948004515 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 153948004516 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 153948004517 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 153948004518 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 153948004519 recombination factor protein RarA; Reviewed; Region: PRK13342 153948004520 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 153948004521 Walker A motif; other site 153948004522 ATP binding site [chemical binding]; other site 153948004523 Walker B motif; other site 153948004524 arginine finger; other site 153948004525 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 153948004526 seryl-tRNA synthetase; Provisional; Region: PRK05431 153948004527 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 153948004528 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 153948004529 dimer interface [polypeptide binding]; other site 153948004530 active site 153948004531 motif 1; other site 153948004532 motif 2; other site 153948004533 motif 3; other site 153948004534 recombination associated protein; Reviewed; Region: rdgC; PRK00321 153948004535 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 153948004536 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 153948004537 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 153948004538 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 153948004539 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 153948004540 RNA binding site [nucleotide binding]; other site 153948004541 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 153948004542 putative transposase OrfB; Reviewed; Region: PHA02517 153948004543 HTH-like domain; Region: HTH_21; pfam13276 153948004544 Integrase core domain; Region: rve; pfam00665 153948004545 Integrase core domain; Region: rve_3; pfam13683 153948004546 BON domain; Region: BON; pfam04972 153948004547 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 153948004548 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 153948004549 ligand binding site [chemical binding]; other site 153948004550 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 153948004551 Transposase; Region: HTH_Tnp_1; pfam01527 153948004552 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 153948004553 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 153948004554 transmembrane helices; other site 153948004555 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 153948004556 TrkA-C domain; Region: TrkA_C; pfam02080 153948004557 TrkA-C domain; Region: TrkA_C; pfam02080 153948004558 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 153948004559 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 153948004560 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 153948004561 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 153948004562 E3 interaction surface; other site 153948004563 lipoyl attachment site [posttranslational modification]; other site 153948004564 e3 binding domain; Region: E3_binding; pfam02817 153948004565 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 153948004566 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 153948004567 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 153948004568 TPP-binding site [chemical binding]; other site 153948004569 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 153948004570 dimer interface [polypeptide binding]; other site 153948004571 PYR/PP interface [polypeptide binding]; other site 153948004572 TPP binding site [chemical binding]; other site 153948004573 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 153948004574 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 153948004575 dimer interface [polypeptide binding]; other site 153948004576 active site 153948004577 citrylCoA binding site [chemical binding]; other site 153948004578 NADH binding [chemical binding]; other site 153948004579 cationic pore residues; other site 153948004580 oxalacetate/citrate binding site [chemical binding]; other site 153948004581 coenzyme A binding site [chemical binding]; other site 153948004582 catalytic triad [active] 153948004583 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 153948004584 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 153948004585 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 153948004586 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 153948004587 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 153948004588 HSP70 interaction site [polypeptide binding]; other site 153948004589 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 153948004590 substrate binding site [polypeptide binding]; other site 153948004591 dimer interface [polypeptide binding]; other site 153948004592 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 153948004593 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 153948004594 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 153948004595 catalytic residues [active] 153948004596 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 153948004597 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 153948004598 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 153948004599 protein binding site [polypeptide binding]; other site 153948004600 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 153948004601 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 153948004602 Family of unknown function (DUF490); Region: DUF490; pfam04357 153948004603 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 153948004604 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 153948004605 Surface antigen; Region: Bac_surface_Ag; pfam01103 153948004606 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 153948004607 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 153948004608 putative NADP binding site [chemical binding]; other site 153948004609 putative substrate binding site [chemical binding]; other site 153948004610 active site 153948004611 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 153948004612 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 153948004613 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 153948004614 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 153948004615 Transposase, Mutator family; Region: Transposase_mut; pfam00872 153948004616 MULE transposase domain; Region: MULE; pfam10551 153948004617 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 153948004618 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 153948004619 ATP binding site [chemical binding]; other site 153948004620 Mg++ binding site [ion binding]; other site 153948004621 motif III; other site 153948004622 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 153948004623 nucleotide binding region [chemical binding]; other site 153948004624 ATP-binding site [chemical binding]; other site 153948004625 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 153948004626 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 153948004627 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 153948004628 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 153948004629 Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447 153948004630 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 153948004631 HEAT repeats; Region: HEAT_2; pfam13646 153948004632 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 153948004633 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 153948004634 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 153948004635 active site 153948004636 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 153948004637 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 153948004638 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 153948004639 Walker A/P-loop; other site 153948004640 ATP binding site [chemical binding]; other site 153948004641 Q-loop/lid; other site 153948004642 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 153948004643 ABC transporter signature motif; other site 153948004644 Walker B; other site 153948004645 D-loop; other site 153948004646 H-loop/switch region; other site 153948004647 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 153948004648 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 153948004649 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 153948004650 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 153948004651 ferrochelatase; Reviewed; Region: hemH; PRK00035 153948004652 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 153948004653 C-terminal domain interface [polypeptide binding]; other site 153948004654 active site 153948004655 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 153948004656 active site 153948004657 N-terminal domain interface [polypeptide binding]; other site 153948004658 Putative serine esterase (DUF676); Region: DUF676; pfam05057 153948004659 Transposase domain (DUF772); Region: DUF772; pfam05598 153948004660 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 153948004661 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 153948004662 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 153948004663 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 153948004664 active site 153948004665 tetramer interface; other site 153948004666 UDP-glucose 4-epimerase; Region: PLN02240 153948004667 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 153948004668 NAD binding site [chemical binding]; other site 153948004669 homodimer interface [polypeptide binding]; other site 153948004670 active site 153948004671 substrate binding site [chemical binding]; other site 153948004672 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 153948004673 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 153948004674 CysD dimerization site [polypeptide binding]; other site 153948004675 G1 box; other site 153948004676 putative GEF interaction site [polypeptide binding]; other site 153948004677 GTP/Mg2+ binding site [chemical binding]; other site 153948004678 Switch I region; other site 153948004679 G2 box; other site 153948004680 G3 box; other site 153948004681 Switch II region; other site 153948004682 G4 box; other site 153948004683 G5 box; other site 153948004684 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 153948004685 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 153948004686 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 153948004687 ligand-binding site [chemical binding]; other site 153948004688 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 153948004689 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 153948004690 Active Sites [active] 153948004691 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 153948004692 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 153948004693 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 153948004694 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 153948004695 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 153948004696 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 153948004697 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 153948004698 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 153948004699 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 153948004700 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 153948004701 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 153948004702 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 153948004703 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 153948004704 metal binding site [ion binding]; metal-binding site 153948004705 active site 153948004706 I-site; other site 153948004707 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 153948004708 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 153948004709 acyl-activating enzyme (AAE) consensus motif; other site 153948004710 AMP binding site [chemical binding]; other site 153948004711 active site 153948004712 CoA binding site [chemical binding]; other site 153948004713 Transposase domain (DUF772); Region: DUF772; pfam05598 153948004714 putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073 153948004715 heat shock protein HtpX; Provisional; Region: PRK05457 153948004716 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 153948004717 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 153948004718 enolase; Provisional; Region: eno; PRK00077 153948004719 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 153948004720 dimer interface [polypeptide binding]; other site 153948004721 metal binding site [ion binding]; metal-binding site 153948004722 substrate binding pocket [chemical binding]; other site 153948004723 CTP synthetase; Validated; Region: pyrG; PRK05380 153948004724 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 153948004725 Catalytic site [active] 153948004726 active site 153948004727 UTP binding site [chemical binding]; other site 153948004728 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 153948004729 active site 153948004730 putative oxyanion hole; other site 153948004731 catalytic triad [active] 153948004732 Phosphotransferase enzyme family; Region: APH; pfam01636 153948004733 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 153948004734 active site 153948004735 ATP binding site [chemical binding]; other site 153948004736 argininosuccinate lyase; Provisional; Region: PRK00855 153948004737 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 153948004738 active sites [active] 153948004739 tetramer interface [polypeptide binding]; other site 153948004740 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 153948004741 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 153948004742 hinge; other site 153948004743 active site 153948004744 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 153948004745 homotrimer interaction site [polypeptide binding]; other site 153948004746 putative active site [active] 153948004747 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 153948004748 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 153948004749 generic binding surface II; other site 153948004750 ssDNA binding site; other site 153948004751 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 153948004752 ATP binding site [chemical binding]; other site 153948004753 putative Mg++ binding site [ion binding]; other site 153948004754 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 153948004755 nucleotide binding region [chemical binding]; other site 153948004756 ATP-binding site [chemical binding]; other site 153948004757 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 153948004758 Transposase; Region: HTH_Tnp_1; pfam01527 153948004759 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 153948004760 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 153948004761 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06943 153948004762 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 153948004763 inhibitor-cofactor binding pocket; inhibition site 153948004764 pyridoxal 5'-phosphate binding site [chemical binding]; other site 153948004765 catalytic residue [active] 153948004766 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 153948004767 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 153948004768 Beta-Casp domain; Region: Beta-Casp; smart01027 153948004769 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 153948004770 Transposase domain (DUF772); Region: DUF772; pfam05598 153948004771 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 153948004772 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 153948004773 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 153948004774 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 153948004775 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 153948004776 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 153948004777 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 153948004778 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 153948004779 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 153948004780 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 153948004781 PEP-CTERM motif; Region: VPEP; pfam07589 153948004782 Transposase domain (DUF772); Region: DUF772; pfam05598 153948004783 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 153948004784 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 153948004785 BON domain; Region: BON; pfam04972 153948004786 K+ potassium transporter; Region: K_trans; cl15781 153948004787 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 153948004788 Mechanosensitive ion channel; Region: MS_channel; pfam00924 153948004789 Transposase domain (DUF772); Region: DUF772; pfam05598 153948004790 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 153948004791 putative catalytic site [active] 153948004792 putative phosphate binding site [ion binding]; other site 153948004793 putative metal binding site [ion binding]; other site 153948004794 Transposase IS200 like; Region: Y1_Tnp; pfam01797 153948004795 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 153948004796 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 153948004797 Transposase; Region: HTH_Tnp_1; pfam01527 153948004798 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 153948004799 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 153948004800 PLD-like domain; Region: PLDc_2; pfam13091 153948004801 putative active site [active] 153948004802 catalytic site [active] 153948004803 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 153948004804 PLD-like domain; Region: PLDc_2; pfam13091 153948004805 putative active site [active] 153948004806 catalytic site [active] 153948004807 Predicted metalloprotease [General function prediction only]; Region: COG2321 153948004808 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 153948004809 Protein of unknown function (DUF3465); Region: DUF3465; pfam11948 153948004810 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 153948004811 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 153948004812 Chromate transporter; Region: Chromate_transp; pfam02417 153948004813 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 153948004814 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 153948004815 substrate binding site [chemical binding]; other site 153948004816 ATP binding site [chemical binding]; other site 153948004817 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 153948004818 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 153948004819 tetramer interface [polypeptide binding]; other site 153948004820 pyridoxal 5'-phosphate binding site [chemical binding]; other site 153948004821 catalytic residue [active] 153948004822 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 153948004823 dimer interface [polypeptide binding]; other site 153948004824 catalytic triad [active] 153948004825 peroxidatic and resolving cysteines [active] 153948004826 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 153948004827 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 153948004828 tetramer interface [polypeptide binding]; other site 153948004829 pyridoxal 5'-phosphate binding site [chemical binding]; other site 153948004830 catalytic residue [active] 153948004831 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 153948004832 lipoyl attachment site [posttranslational modification]; other site 153948004833 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 153948004834 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 153948004835 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 153948004836 cytochrome c-550; Provisional; Region: psbV; cl17239 153948004837 Cytochrome c; Region: Cytochrom_C; pfam00034 153948004838 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 153948004839 BON domain; Region: BON; pfam04972 153948004840 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 153948004841 dimerization interface [polypeptide binding]; other site 153948004842 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 153948004843 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 153948004844 FtsX-like permease family; Region: FtsX; pfam02687 153948004845 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 153948004846 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 153948004847 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 153948004848 catalytic residues [active] 153948004849 dimer interface [polypeptide binding]; other site 153948004850 Peptidase C13 family; Region: Peptidase_C13; cl02159 153948004851 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 153948004852 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 153948004853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948004854 active site 153948004855 phosphorylation site [posttranslational modification] 153948004856 intermolecular recognition site; other site 153948004857 dimerization interface [polypeptide binding]; other site 153948004858 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 153948004859 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 153948004860 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 153948004861 Response regulator receiver domain; Region: Response_reg; pfam00072 153948004862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948004863 active site 153948004864 phosphorylation site [posttranslational modification] 153948004865 intermolecular recognition site; other site 153948004866 dimerization interface [polypeptide binding]; other site 153948004867 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 153948004868 Kelch domain; Region: Kelch; smart00612 153948004869 Kelch motif; Region: Kelch_1; pfam01344 153948004870 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 153948004871 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 153948004872 Kelch domain; Region: Kelch; smart00612 153948004873 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 153948004874 Kelch domain; Region: Kelch; smart00612 153948004875 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 153948004876 Kelch domain; Region: Kelch; smart00612 153948004877 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 153948004878 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 153948004879 Coenzyme A binding pocket [chemical binding]; other site 153948004880 Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247 153948004881 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 153948004882 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 153948004883 EamA-like transporter family; Region: EamA; pfam00892 153948004884 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 153948004885 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 153948004886 [2Fe-2S] cluster binding site [ion binding]; other site 153948004887 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 153948004888 alpha subunit interface [polypeptide binding]; other site 153948004889 active site 153948004890 substrate binding site [chemical binding]; other site 153948004891 Fe binding site [ion binding]; other site 153948004892 primosome assembly protein PriA; Validated; Region: PRK05580 153948004893 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 153948004894 ATP binding site [chemical binding]; other site 153948004895 putative Mg++ binding site [ion binding]; other site 153948004896 helicase superfamily c-terminal domain; Region: HELICc; smart00490 153948004897 ATP-binding site [chemical binding]; other site 153948004898 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 153948004899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 153948004900 ATP binding site [chemical binding]; other site 153948004901 Mg2+ binding site [ion binding]; other site 153948004902 G-X-G motif; other site 153948004903 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 153948004904 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948004905 active site 153948004906 phosphorylation site [posttranslational modification] 153948004907 intermolecular recognition site; other site 153948004908 dimerization interface [polypeptide binding]; other site 153948004909 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 153948004910 DNA binding residues [nucleotide binding] 153948004911 dimerization interface [polypeptide binding]; other site 153948004912 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 153948004913 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 153948004914 ATP-binding cassette domain of MutS homologs; Region: ABC_MutS_homologs; cd03243 153948004915 Walker A/P-loop; other site 153948004916 ATP binding site [chemical binding]; other site 153948004917 Q-loop/lid; other site 153948004918 ABC transporter signature motif; other site 153948004919 Walker B; other site 153948004920 D-loop; other site 153948004921 H-loop/switch region; other site 153948004922 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 153948004923 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 153948004924 HlyD family secretion protein; Region: HlyD_3; pfam13437 153948004925 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 153948004926 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 153948004927 Walker A/P-loop; other site 153948004928 ATP binding site [chemical binding]; other site 153948004929 Q-loop/lid; other site 153948004930 ABC transporter signature motif; other site 153948004931 Walker B; other site 153948004932 D-loop; other site 153948004933 H-loop/switch region; other site 153948004934 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 153948004935 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 153948004936 FtsX-like permease family; Region: FtsX; pfam02687 153948004937 Transposase IS200 like; Region: Y1_Tnp; pfam01797 153948004938 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 153948004939 Bacteriophage replication protein O; Region: Phage_rep_O; cl04545 153948004940 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 153948004941 ParB-like nuclease domain; Region: ParB; smart00470 153948004942 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 153948004943 active site 153948004944 metal binding site [ion binding]; metal-binding site 153948004945 Helix-turn-helix domain; Region: HTH_39; pfam14090 153948004946 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 153948004947 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 153948004948 Protein of unknown function (DUF497); Region: DUF497; pfam04365 153948004949 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 153948004950 active site 153948004951 DNA binding site [nucleotide binding] 153948004952 Int/Topo IB signature motif; other site 153948004953 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 153948004954 Helix-turn-helix domain; Region: HTH_38; pfam13936 153948004955 Integrase core domain; Region: rve; pfam00665 153948004956 transposase/IS protein; Provisional; Region: PRK09183 153948004957 Putative ATP-dependent Lon protease; Region: Lon_2; cl11979 153948004958 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 153948004959 Walker A motif; other site 153948004960 ATP binding site [chemical binding]; other site 153948004961 Walker B motif; other site 153948004962 arginine finger; other site 153948004963 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 153948004964 High potential iron-sulfur protein; Region: HIPIP; pfam01355 153948004965 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 153948004966 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 153948004967 ATP binding site [chemical binding]; other site 153948004968 putative Mg++ binding site [ion binding]; other site 153948004969 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 153948004970 nucleotide binding region [chemical binding]; other site 153948004971 ATP-binding site [chemical binding]; other site 153948004972 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 153948004973 HRDC domain; Region: HRDC; pfam00570 153948004974 glutamine synthetase; Provisional; Region: glnA; PRK09469 153948004975 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 153948004976 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 153948004977 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 153948004978 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 153948004979 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 153948004980 putative catalytic site [active] 153948004981 putative phosphate binding site [ion binding]; other site 153948004982 active site 153948004983 metal binding site A [ion binding]; metal-binding site 153948004984 DNA binding site [nucleotide binding] 153948004985 putative AP binding site [nucleotide binding]; other site 153948004986 putative metal binding site B [ion binding]; other site 153948004987 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 153948004988 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 153948004989 ATP binding site [chemical binding]; other site 153948004990 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 153948004991 hypothetical protein; Validated; Region: PRK01777 153948004992 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 153948004993 putative coenzyme Q binding site [chemical binding]; other site 153948004994 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 153948004995 SmpB-tmRNA interface; other site 153948004996 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 153948004997 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 153948004998 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 153948004999 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 153948005000 dimer interface [polypeptide binding]; other site 153948005001 active site 153948005002 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 153948005003 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 153948005004 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 153948005005 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 153948005006 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 153948005007 substrate binding site [chemical binding]; other site 153948005008 oxyanion hole (OAH) forming residues; other site 153948005009 trimer interface [polypeptide binding]; other site 153948005010 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 153948005011 ArsC family; Region: ArsC; pfam03960 153948005012 putative ArsC-like catalytic residues; other site 153948005013 putative TRX-like catalytic residues [active] 153948005014 Cupin domain; Region: Cupin_2; pfam07883 153948005015 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 153948005016 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 153948005017 Walker A motif; other site 153948005018 ATP binding site [chemical binding]; other site 153948005019 Walker B motif; other site 153948005020 arginine finger; other site 153948005021 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 153948005022 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 153948005023 Serine hydrolase; Region: Ser_hydrolase; cl17834 153948005024 Family description; Region: VCBS; pfam13517 153948005025 Family description; Region: VCBS; pfam13517 153948005026 Family description; Region: VCBS; pfam13517 153948005027 Family description; Region: VCBS; pfam13517 153948005028 Family description; Region: VCBS; pfam13517 153948005029 Family description; Region: VCBS; pfam13517 153948005030 Family description; Region: VCBS; pfam13517 153948005031 Family description; Region: VCBS; pfam13517 153948005032 TIGR03032 family protein; Region: TIGR03032 153948005033 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 153948005034 Bacterial SH3 domain; Region: SH3_3; cl17532 153948005035 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 153948005036 L-aspartate oxidase; Provisional; Region: PRK06175 153948005037 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 153948005038 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 153948005039 SdhC subunit interface [polypeptide binding]; other site 153948005040 proximal heme binding site [chemical binding]; other site 153948005041 cardiolipin binding site; other site 153948005042 Iron-sulfur protein interface; other site 153948005043 proximal quinone binding site [chemical binding]; other site 153948005044 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 153948005045 Iron-sulfur protein interface; other site 153948005046 proximal quinone binding site [chemical binding]; other site 153948005047 SdhD (CybS) interface [polypeptide binding]; other site 153948005048 proximal heme binding site [chemical binding]; other site 153948005049 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 153948005050 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 153948005051 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 153948005052 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 153948005053 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 153948005054 pyridoxal 5'-phosphate binding site [chemical binding]; other site 153948005055 homodimer interface [polypeptide binding]; other site 153948005056 catalytic residue [active] 153948005057 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 153948005058 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 153948005059 trimer interface [polypeptide binding]; other site 153948005060 active site 153948005061 substrate binding site [chemical binding]; other site 153948005062 CoA binding site [chemical binding]; other site 153948005063 BON domain; Region: BON; pfam04972 153948005064 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 153948005065 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 153948005066 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 153948005067 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 153948005068 HI0933-like protein; Region: HI0933_like; pfam03486 153948005069 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 153948005070 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 153948005071 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 153948005072 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 153948005073 Repair protein; Region: Repair_PSII; pfam04536 153948005074 Repair protein; Region: Repair_PSII; pfam04536 153948005075 tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791 153948005076 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 153948005077 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 153948005078 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 153948005079 BON domain; Region: BON; pfam04972 153948005080 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 153948005081 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 153948005082 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 153948005083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 153948005084 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 153948005085 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 153948005086 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 153948005087 BON domain; Region: BON; pfam04972 153948005088 Predicted membrane protein [Function unknown]; Region: COG2259 153948005089 Pirin-related protein [General function prediction only]; Region: COG1741 153948005090 Pirin; Region: Pirin; pfam02678 153948005091 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 153948005092 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 153948005093 LysR family transcriptional regulator; Provisional; Region: PRK14997 153948005094 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 153948005095 putative effector binding pocket; other site 153948005096 dimerization interface [polypeptide binding]; other site 153948005097 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 153948005098 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 153948005099 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 153948005100 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 153948005101 Sulfatase; Region: Sulfatase; cl17466 153948005102 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 153948005103 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 153948005104 FeS/SAM binding site; other site 153948005105 Methyltransferase domain; Region: Methyltransf_31; pfam13847 153948005106 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 153948005107 S-adenosylmethionine binding site [chemical binding]; other site 153948005108 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 153948005109 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 153948005110 Probable Catalytic site; other site 153948005111 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 153948005112 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 153948005113 nudix motif; other site 153948005114 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 153948005115 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 153948005116 dimer interface [polypeptide binding]; other site 153948005117 anticodon binding site; other site 153948005118 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 153948005119 homodimer interface [polypeptide binding]; other site 153948005120 motif 1; other site 153948005121 active site 153948005122 motif 2; other site 153948005123 GAD domain; Region: GAD; pfam02938 153948005124 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 153948005125 motif 3; other site 153948005126 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 153948005127 aconitate hydratase; Provisional; Region: acnA; PRK12881 153948005128 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 153948005129 substrate binding site [chemical binding]; other site 153948005130 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 153948005131 ligand binding site [chemical binding]; other site 153948005132 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 153948005133 substrate binding site [chemical binding]; other site 153948005134 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 153948005135 Transposase domain (DUF772); Region: DUF772; pfam05598 153948005136 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 153948005137 Uncharacterized conserved protein [Function unknown]; Region: COG3461 153948005138 putative transposase OrfB; Reviewed; Region: PHA02517 153948005139 HTH-like domain; Region: HTH_21; pfam13276 153948005140 Integrase core domain; Region: rve; pfam00665 153948005141 Integrase core domain; Region: rve_3; cl15866 153948005142 Transposase; Region: HTH_Tnp_1; cl17663 153948005143 transposase/IS protein; Provisional; Region: PRK09183 153948005144 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 153948005145 Walker A motif; other site 153948005146 ATP binding site [chemical binding]; other site 153948005147 Walker B motif; other site 153948005148 arginine finger; other site 153948005149 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 153948005150 active site 153948005151 catalytic residues [active] 153948005152 DNA binding site [nucleotide binding] 153948005153 Int/Topo IB signature motif; other site 153948005154 GMP synthase; Reviewed; Region: guaA; PRK00074 153948005155 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 153948005156 AMP/PPi binding site [chemical binding]; other site 153948005157 candidate oxyanion hole; other site 153948005158 catalytic triad [active] 153948005159 potential glutamine specificity residues [chemical binding]; other site 153948005160 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 153948005161 ATP Binding subdomain [chemical binding]; other site 153948005162 Ligand Binding sites [chemical binding]; other site 153948005163 Dimerization subdomain; other site 153948005164 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 153948005165 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 153948005166 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 153948005167 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 153948005168 active site 153948005169 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 153948005170 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 153948005171 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 153948005172 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 153948005173 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 153948005174 ATP binding site [chemical binding]; other site 153948005175 putative Mg++ binding site [ion binding]; other site 153948005176 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 153948005177 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 153948005178 nucleotide binding region [chemical binding]; other site 153948005179 ATP-binding site [chemical binding]; other site 153948005180 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 153948005181 Zn binding site [ion binding]; other site 153948005182 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 153948005183 M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663 153948005184 Peptidase family M28; Region: Peptidase_M28; pfam04389 153948005185 metal binding site [ion binding]; metal-binding site 153948005186 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 153948005187 AAA domain; Region: AAA_13; pfam13166 153948005188 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 153948005189 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 153948005190 dimer interface [polypeptide binding]; other site 153948005191 decamer (pentamer of dimers) interface [polypeptide binding]; other site 153948005192 catalytic triad [active] 153948005193 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 153948005194 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 153948005195 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 153948005196 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 153948005197 TPR motif; other site 153948005198 Tetratricopeptide repeat; Region: TPR_12; pfam13424 153948005199 binding surface 153948005200 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 153948005201 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 153948005202 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 153948005203 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 153948005204 catalytic site [active] 153948005205 subunit interface [polypeptide binding]; other site 153948005206 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 153948005207 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 153948005208 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 153948005209 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 153948005210 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 153948005211 ATP-grasp domain; Region: ATP-grasp_4; cl17255 153948005212 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 153948005213 IMP binding site; other site 153948005214 dimer interface [polypeptide binding]; other site 153948005215 interdomain contacts; other site 153948005216 partial ornithine binding site; other site 153948005217 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 153948005218 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 153948005219 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 153948005220 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 153948005221 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 153948005222 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 153948005223 S-adenosylmethionine binding site [chemical binding]; other site 153948005224 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 153948005225 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 153948005226 Walker A motif; other site 153948005227 ATP binding site [chemical binding]; other site 153948005228 Walker B motif; other site 153948005229 arginine finger; other site 153948005230 Peptidase family M41; Region: Peptidase_M41; pfam01434 153948005231 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 153948005232 dihydropteroate synthase; Region: DHPS; TIGR01496 153948005233 substrate binding pocket [chemical binding]; other site 153948005234 dimer interface [polypeptide binding]; other site 153948005235 inhibitor binding site; inhibition site 153948005236 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 153948005237 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 153948005238 active site 153948005239 substrate binding site [chemical binding]; other site 153948005240 metal binding site [ion binding]; metal-binding site 153948005241 phosphate binding protein; Region: ptsS_2; TIGR02136 153948005242 siroheme synthase; Provisional; Region: cysG; PRK10637 153948005243 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 153948005244 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 153948005245 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 153948005246 active site 153948005247 SAM binding site [chemical binding]; other site 153948005248 homodimer interface [polypeptide binding]; other site 153948005249 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 153948005250 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 153948005251 dimerization interface [polypeptide binding]; other site 153948005252 active site 153948005253 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 153948005254 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 153948005255 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 153948005256 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 153948005257 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 153948005258 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 153948005259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 153948005260 dimer interface [polypeptide binding]; other site 153948005261 conserved gate region; other site 153948005262 putative PBP binding loops; other site 153948005263 ABC-ATPase subunit interface; other site 153948005264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 153948005265 dimer interface [polypeptide binding]; other site 153948005266 conserved gate region; other site 153948005267 putative PBP binding loops; other site 153948005268 ABC-ATPase subunit interface; other site 153948005269 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 153948005270 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 153948005271 Walker A/P-loop; other site 153948005272 ATP binding site [chemical binding]; other site 153948005273 Q-loop/lid; other site 153948005274 ABC transporter signature motif; other site 153948005275 Walker B; other site 153948005276 D-loop; other site 153948005277 H-loop/switch region; other site 153948005278 TOBE-like domain; Region: TOBE_3; pfam12857 153948005279 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 153948005280 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683 153948005281 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 153948005282 dimerization interface [polypeptide binding]; other site 153948005283 putative Zn2+ binding site [ion binding]; other site 153948005284 putative DNA binding site [nucleotide binding]; other site 153948005285 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 153948005286 substrate binding site [chemical binding]; other site 153948005287 dimerization interface [polypeptide binding]; other site 153948005288 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 153948005289 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 153948005290 active site 153948005291 FMN binding site [chemical binding]; other site 153948005292 substrate binding site [chemical binding]; other site 153948005293 3Fe-4S cluster binding site [ion binding]; other site 153948005294 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 153948005295 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 153948005296 metal binding site [ion binding]; metal-binding site 153948005297 active site 153948005298 I-site; other site 153948005299 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 153948005300 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 153948005301 Clp amino terminal domain; Region: Clp_N; pfam02861 153948005302 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 153948005303 Walker A motif; other site 153948005304 ATP binding site [chemical binding]; other site 153948005305 Walker B motif; other site 153948005306 arginine finger; other site 153948005307 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 153948005308 Walker A motif; other site 153948005309 ATP binding site [chemical binding]; other site 153948005310 Walker B motif; other site 153948005311 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 153948005312 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 153948005313 dihydrodipicolinate synthase; Region: dapA; TIGR00674 153948005314 dimer interface [polypeptide binding]; other site 153948005315 active site 153948005316 catalytic residue [active] 153948005317 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 153948005318 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 153948005319 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 153948005320 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 153948005321 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 153948005322 HlyD family secretion protein; Region: HlyD_3; pfam13437 153948005323 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 153948005324 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 153948005325 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 153948005326 Walker A/P-loop; other site 153948005327 ATP binding site [chemical binding]; other site 153948005328 Q-loop/lid; other site 153948005329 ABC transporter signature motif; other site 153948005330 Walker B; other site 153948005331 D-loop; other site 153948005332 H-loop/switch region; other site 153948005333 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 153948005334 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 153948005335 NAD(P) binding site [chemical binding]; other site 153948005336 active site 153948005337 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 153948005338 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 153948005339 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 153948005340 active site 153948005341 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 153948005342 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 153948005343 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948005344 active site 153948005345 phosphorylation site [posttranslational modification] 153948005346 intermolecular recognition site; other site 153948005347 dimerization interface [polypeptide binding]; other site 153948005348 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 153948005349 DNA binding residues [nucleotide binding] 153948005350 dimerization interface [polypeptide binding]; other site 153948005351 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; pfam07073 153948005352 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 153948005353 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 153948005354 minor groove reading motif; other site 153948005355 helix-hairpin-helix signature motif; other site 153948005356 substrate binding pocket [chemical binding]; other site 153948005357 active site 153948005358 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 153948005359 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 153948005360 DNA binding and oxoG recognition site [nucleotide binding] 153948005361 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 153948005362 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 153948005363 aromatic acid decarboxylase; Validated; Region: PRK05920 153948005364 Flavoprotein; Region: Flavoprotein; pfam02441 153948005365 HPr kinase/phosphorylase; Provisional; Region: PRK05428 153948005366 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 153948005367 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 153948005368 Hpr binding site; other site 153948005369 active site 153948005370 homohexamer subunit interaction site [polypeptide binding]; other site 153948005371 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 153948005372 active site 153948005373 phosphorylation site [posttranslational modification] 153948005374 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 153948005375 30S subunit binding site; other site 153948005376 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 153948005377 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 153948005378 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 153948005379 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 153948005380 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 153948005381 Walker A/P-loop; other site 153948005382 ATP binding site [chemical binding]; other site 153948005383 Q-loop/lid; other site 153948005384 ABC transporter signature motif; other site 153948005385 Walker B; other site 153948005386 D-loop; other site 153948005387 H-loop/switch region; other site 153948005388 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 153948005389 OstA-like protein; Region: OstA; pfam03968 153948005390 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 153948005391 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 153948005392 quinolinate synthetase; Provisional; Region: PRK09375 153948005393 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 153948005394 PLD-like domain; Region: PLDc_2; pfam13091 153948005395 putative active site [active] 153948005396 catalytic site [active] 153948005397 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 153948005398 PLD-like domain; Region: PLDc_2; pfam13091 153948005399 putative active site [active] 153948005400 catalytic site [active] 153948005401 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 153948005402 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 153948005403 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 153948005404 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 153948005405 motif II; other site 153948005406 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 153948005407 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 153948005408 Peptidase family M23; Region: Peptidase_M23; pfam01551 153948005409 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 153948005410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 153948005411 S-adenosylmethionine binding site [chemical binding]; other site 153948005412 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 153948005413 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 153948005414 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 153948005415 DNA binding residues [nucleotide binding] 153948005416 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 153948005417 IHF dimer interface [polypeptide binding]; other site 153948005418 IHF - DNA interface [nucleotide binding]; other site 153948005419 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 153948005420 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 153948005421 putative tRNA-binding site [nucleotide binding]; other site 153948005422 B3/4 domain; Region: B3_4; pfam03483 153948005423 tRNA synthetase B5 domain; Region: B5; smart00874 153948005424 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 153948005425 dimer interface [polypeptide binding]; other site 153948005426 motif 1; other site 153948005427 motif 3; other site 153948005428 motif 2; other site 153948005429 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 153948005430 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 153948005431 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 153948005432 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 153948005433 dimer interface [polypeptide binding]; other site 153948005434 motif 1; other site 153948005435 active site 153948005436 motif 2; other site 153948005437 motif 3; other site 153948005438 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 153948005439 23S rRNA binding site [nucleotide binding]; other site 153948005440 L21 binding site [polypeptide binding]; other site 153948005441 L13 binding site [polypeptide binding]; other site 153948005442 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 153948005443 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 153948005444 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 153948005445 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 153948005446 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 153948005447 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 153948005448 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 153948005449 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 153948005450 active site 153948005451 dimer interface [polypeptide binding]; other site 153948005452 motif 1; other site 153948005453 motif 2; other site 153948005454 motif 3; other site 153948005455 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 153948005456 anticodon binding site; other site 153948005457 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 153948005458 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 153948005459 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 153948005460 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 153948005461 Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447 153948005462 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 153948005463 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 153948005464 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 153948005465 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 153948005466 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 153948005467 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 153948005468 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 153948005469 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 153948005470 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 153948005471 DNA binding site [nucleotide binding] 153948005472 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 153948005473 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 153948005474 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 153948005475 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 153948005476 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 153948005477 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 153948005478 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 153948005479 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 153948005480 RPB3 interaction site [polypeptide binding]; other site 153948005481 RPB1 interaction site [polypeptide binding]; other site 153948005482 RPB11 interaction site [polypeptide binding]; other site 153948005483 RPB10 interaction site [polypeptide binding]; other site 153948005484 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 153948005485 peripheral dimer interface [polypeptide binding]; other site 153948005486 core dimer interface [polypeptide binding]; other site 153948005487 L10 interface [polypeptide binding]; other site 153948005488 L11 interface [polypeptide binding]; other site 153948005489 putative EF-Tu interaction site [polypeptide binding]; other site 153948005490 putative EF-G interaction site [polypeptide binding]; other site 153948005491 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 153948005492 23S rRNA interface [nucleotide binding]; other site 153948005493 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 153948005494 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 153948005495 mRNA/rRNA interface [nucleotide binding]; other site 153948005496 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 153948005497 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 153948005498 23S rRNA interface [nucleotide binding]; other site 153948005499 L7/L12 interface [polypeptide binding]; other site 153948005500 putative thiostrepton binding site; other site 153948005501 L25 interface [polypeptide binding]; other site 153948005502 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 153948005503 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 153948005504 putative homodimer interface [polypeptide binding]; other site 153948005505 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 153948005506 heterodimer interface [polypeptide binding]; other site 153948005507 homodimer interface [polypeptide binding]; other site 153948005508 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 153948005509 elongation factor Tu; Reviewed; Region: PRK00049 153948005510 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 153948005511 G1 box; other site 153948005512 GEF interaction site [polypeptide binding]; other site 153948005513 GTP/Mg2+ binding site [chemical binding]; other site 153948005514 Switch I region; other site 153948005515 G2 box; other site 153948005516 G3 box; other site 153948005517 Switch II region; other site 153948005518 G4 box; other site 153948005519 G5 box; other site 153948005520 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 153948005521 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 153948005522 Antibiotic Binding Site [chemical binding]; other site 153948005523 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 153948005524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 153948005525 dimer interface [polypeptide binding]; other site 153948005526 conserved gate region; other site 153948005527 putative PBP binding loops; other site 153948005528 ABC-ATPase subunit interface; other site 153948005529 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505 153948005530 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 153948005531 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997 153948005532 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 153948005533 NAD binding site [chemical binding]; other site 153948005534 homotetramer interface [polypeptide binding]; other site 153948005535 homodimer interface [polypeptide binding]; other site 153948005536 substrate binding site [chemical binding]; other site 153948005537 active site 153948005538 SurA N-terminal domain; Region: SurA_N_3; cl07813 153948005539 periplasmic folding chaperone; Provisional; Region: PRK10788 153948005540 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 153948005541 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 153948005542 IHF dimer interface [polypeptide binding]; other site 153948005543 IHF - DNA interface [nucleotide binding]; other site 153948005544 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 153948005545 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 153948005546 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 153948005547 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 153948005548 preprotein translocase subunit SecB; Validated; Region: PRK05751 153948005549 SecA binding site; other site 153948005550 Preprotein binding site; other site 153948005551 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 153948005552 GSH binding site [chemical binding]; other site 153948005553 catalytic residues [active] 153948005554 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 153948005555 active site residue [active] 153948005556 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 153948005557 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 153948005558 Cysteine-rich domain; Region: CCG; pfam02754 153948005559 Cysteine-rich domain; Region: CCG; pfam02754 153948005560 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 153948005561 FAD binding domain; Region: FAD_binding_4; pfam01565 153948005562 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 153948005563 FAD binding domain; Region: FAD_binding_4; pfam01565 153948005564 2-hydroxy-3-oxopropionate reductase; Region: tartro_sem_red; TIGR01505 153948005565 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 153948005566 Transposase domain (DUF772); Region: DUF772; pfam05598 153948005567 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 153948005568 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 153948005569 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 153948005570 Coenzyme A binding pocket [chemical binding]; other site 153948005571 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 153948005572 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 153948005573 GDP-binding site [chemical binding]; other site 153948005574 ACT binding site; other site 153948005575 IMP binding site; other site 153948005576 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 153948005577 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 153948005578 dimer interface [polypeptide binding]; other site 153948005579 motif 1; other site 153948005580 active site 153948005581 motif 2; other site 153948005582 motif 3; other site 153948005583 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 153948005584 HflC protein; Region: hflC; TIGR01932 153948005585 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 153948005586 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 153948005587 HflK protein; Region: hflK; TIGR01933 153948005588 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 153948005589 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 153948005590 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 153948005591 HflX GTPase family; Region: HflX; cd01878 153948005592 G1 box; other site 153948005593 GTP/Mg2+ binding site [chemical binding]; other site 153948005594 Switch I region; other site 153948005595 G2 box; other site 153948005596 G3 box; other site 153948005597 Switch II region; other site 153948005598 G4 box; other site 153948005599 G5 box; other site 153948005600 bacterial Hfq-like; Region: Hfq; cd01716 153948005601 hexamer interface [polypeptide binding]; other site 153948005602 Sm1 motif; other site 153948005603 RNA binding site [nucleotide binding]; other site 153948005604 Sm2 motif; other site 153948005605 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 153948005606 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 153948005607 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 153948005608 putative active site [active] 153948005609 Ap4A binding site [chemical binding]; other site 153948005610 nudix motif; other site 153948005611 putative metal binding site [ion binding]; other site 153948005612 prolyl-tRNA synthetase; Provisional; Region: PRK09194 153948005613 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 153948005614 dimer interface [polypeptide binding]; other site 153948005615 motif 1; other site 153948005616 active site 153948005617 motif 2; other site 153948005618 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 153948005619 putative deacylase active site [active] 153948005620 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 153948005621 active site 153948005622 motif 3; other site 153948005623 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 153948005624 anticodon binding site; other site 153948005625 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 153948005626 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 153948005627 N-acetyl-D-glucosamine binding site [chemical binding]; other site 153948005628 catalytic residue [active] 153948005629 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 153948005630 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 153948005631 catalytic residues [active] 153948005632 2-isopropylmalate synthase; Validated; Region: PRK00915 153948005633 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 153948005634 active site 153948005635 catalytic residues [active] 153948005636 metal binding site [ion binding]; metal-binding site 153948005637 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 153948005638 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 153948005639 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 153948005640 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 153948005641 ketol-acid reductoisomerase; Provisional; Region: PRK05479 153948005642 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 153948005643 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 153948005644 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 153948005645 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 153948005646 putative valine binding site [chemical binding]; other site 153948005647 dimer interface [polypeptide binding]; other site 153948005648 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 153948005649 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 153948005650 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 153948005651 PYR/PP interface [polypeptide binding]; other site 153948005652 dimer interface [polypeptide binding]; other site 153948005653 TPP binding site [chemical binding]; other site 153948005654 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 153948005655 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 153948005656 TPP-binding site [chemical binding]; other site 153948005657 dimer interface [polypeptide binding]; other site 153948005658 protease TldD; Provisional; Region: tldD; PRK10735 153948005659 nitrilase; Region: PLN02798 153948005660 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 153948005661 putative active site [active] 153948005662 catalytic triad [active] 153948005663 dimer interface [polypeptide binding]; other site 153948005664 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 153948005665 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 153948005666 metal binding triad; other site 153948005667 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 153948005668 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 153948005669 metal binding triad; other site 153948005670 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 153948005671 putative major pilin subunit; Provisional; Region: PRK10574 153948005672 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 153948005673 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 153948005674 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 153948005675 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 153948005676 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 153948005677 Walker A motif; other site 153948005678 ATP binding site [chemical binding]; other site 153948005679 Walker B motif; other site 153948005680 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 153948005681 cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776 153948005682 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 153948005683 Ligand Binding Site [chemical binding]; other site 153948005684 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 153948005685 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 153948005686 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 153948005687 active site 153948005688 nucleophile elbow; other site 153948005689 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 153948005690 TAP-like protein; Region: Abhydrolase_4; pfam08386 153948005691 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 153948005692 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 153948005693 Active Sites [active] 153948005694 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 153948005695 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 153948005696 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 153948005697 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 153948005698 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 153948005699 metal ion-dependent adhesion site (MIDAS); other site 153948005700 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 153948005701 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 153948005702 Walker A/P-loop; other site 153948005703 ATP binding site [chemical binding]; other site 153948005704 Q-loop/lid; other site 153948005705 ABC transporter signature motif; other site 153948005706 Walker B; other site 153948005707 D-loop; other site 153948005708 H-loop/switch region; other site 153948005709 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 153948005710 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 153948005711 dimer interface [polypeptide binding]; other site 153948005712 conserved gate region; other site 153948005713 putative PBP binding loops; other site 153948005714 ABC-ATPase subunit interface; other site 153948005715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 153948005716 dimer interface [polypeptide binding]; other site 153948005717 conserved gate region; other site 153948005718 putative PBP binding loops; other site 153948005719 ABC-ATPase subunit interface; other site 153948005720 PBP superfamily domain; Region: PBP_like_2; cl17296 153948005721 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 153948005722 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 153948005723 Sodium Bile acid symporter family; Region: SBF; pfam01758 153948005724 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 153948005725 Helix-turn-helix domain; Region: HTH_38; pfam13936 153948005726 Homeodomain-like domain; Region: HTH_32; pfam13565 153948005727 Integrase core domain; Region: rve; pfam00665 153948005728 FG-GAP repeat; Region: FG-GAP; cl15299 153948005729 FG-GAP repeat; Region: FG-GAP; cl15299 153948005730 FG-GAP repeat; Region: FG-GAP; cl15299 153948005731 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 153948005732 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 153948005733 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 153948005734 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 153948005735 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 153948005736 TPR repeat; Region: TPR_11; pfam13414 153948005737 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 153948005738 binding surface 153948005739 TPR motif; other site 153948005740 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 153948005741 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 153948005742 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 153948005743 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 153948005744 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 153948005745 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 153948005746 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 153948005747 Rubrerythrin [Energy production and conversion]; Region: COG1592 153948005748 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 153948005749 Sulfate transporter family; Region: Sulfate_transp; pfam00916 153948005750 Predicted membrane protein [Function unknown]; Region: COG4325 153948005751 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 153948005752 Bacterial SH3 domain; Region: SH3_3; pfam08239 153948005753 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 153948005754 dimerization interface [polypeptide binding]; other site 153948005755 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 153948005756 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 153948005757 metal binding site [ion binding]; metal-binding site 153948005758 active site 153948005759 I-site; other site 153948005760 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 153948005761 apolar tunnel; other site 153948005762 heme binding site [chemical binding]; other site 153948005763 dimerization interface [polypeptide binding]; other site 153948005764 malate dehydrogenase; Provisional; Region: PRK13529 153948005765 Malic enzyme, N-terminal domain; Region: malic; pfam00390 153948005766 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 153948005767 NAD(P) binding site [chemical binding]; other site 153948005768 Domain of unknown function (DUF4072); Region: DUF4072; pfam13284 153948005769 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 153948005770 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 153948005771 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 153948005772 motif II; other site 153948005773 HDOD domain; Region: HDOD; pfam08668 153948005774 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 153948005775 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 153948005776 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 153948005777 metal binding site [ion binding]; metal-binding site 153948005778 active site 153948005779 I-site; other site 153948005780 multifunctional aminopeptidase A; Provisional; Region: PRK00913 153948005781 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 153948005782 interface (dimer of trimers) [polypeptide binding]; other site 153948005783 Substrate-binding/catalytic site; other site 153948005784 Zn-binding sites [ion binding]; other site 153948005785 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 153948005786 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 153948005787 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 153948005788 HIGH motif; other site 153948005789 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 153948005790 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 153948005791 active site 153948005792 KMSKS motif; other site 153948005793 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 153948005794 tRNA binding surface [nucleotide binding]; other site 153948005795 anticodon binding site; other site 153948005796 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 153948005797 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 153948005798 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948005799 active site 153948005800 phosphorylation site [posttranslational modification] 153948005801 intermolecular recognition site; other site 153948005802 dimerization interface [polypeptide binding]; other site 153948005803 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 153948005804 DNA binding residues [nucleotide binding] 153948005805 dimerization interface [polypeptide binding]; other site 153948005806 Transposase domain (DUF772); Region: DUF772; pfam05598 153948005807 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 153948005808 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 153948005809 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 153948005810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 153948005811 active site 153948005812 phosphorylation site [posttranslational modification] 153948005813 intermolecular recognition site; other site 153948005814 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 153948005815 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 153948005816 FlaG protein; Region: FlaG; pfam03646 153948005817 flagellar capping protein; Reviewed; Region: fliD; PRK08032 153948005818 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 153948005819 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 153948005820 flagellar protein FliS; Validated; Region: fliS; PRK05685 153948005821 Flagellar protein FliT; Region: FliT; pfam05400 153948005822 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 153948005823 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 153948005824 Flagellar regulator YcgR; Region: YcgR; pfam07317 153948005825 PilZ domain; Region: PilZ; pfam07238 153948005826 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 153948005827 Integrase core domain; Region: rve; pfam00665 153948005828 transposase/IS protein; Provisional; Region: PRK09183 153948005829 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 153948005830 Walker A motif; other site 153948005831 ATP binding site [chemical binding]; other site 153948005832 Walker B motif; other site 153948005833 arginine finger; other site 153948005834 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 153948005835 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 153948005836 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 153948005837 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 153948005838 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 153948005839 DNA binding residues [nucleotide binding] 153948005840 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 153948005841 PAS fold; Region: PAS_4; pfam08448 153948005842 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 153948005843 putative active site [active] 153948005844 heme pocket [chemical binding]; other site 153948005845 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 153948005846 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 153948005847 metal binding site [ion binding]; metal-binding site 153948005848 active site 153948005849 I-site; other site 153948005850 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 153948005851 hypothetical protein; Provisional; Region: PRK09256 153948005852 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 153948005853 HsdM N-terminal domain; Region: HsdM_N; pfam12161 153948005854 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 153948005855 Methyltransferase domain; Region: Methyltransf_26; pfam13659 153948005856 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 153948005857 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 153948005858 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 153948005859 Transposase IS200 like; Region: Y1_Tnp; cl00848 153948005860 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 153948005861 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 153948005862 putative active site [active] 153948005863 Transposase; Region: HTH_Tnp_1; cl17663 153948005864 putative transposase OrfB; Reviewed; Region: PHA02517 153948005865 HTH-like domain; Region: HTH_21; pfam13276 153948005866 Integrase core domain; Region: rve; pfam00665 153948005867 Integrase core domain; Region: rve_3; cl15866 153948005868 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 153948005869 putative metal binding site [ion binding]; other site 153948005870 Uncharacterized conserved protein [Function unknown]; Region: COG1432 153948005871 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 153948005872 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 153948005873 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 153948005874 Uncharacterized conserved protein [Function unknown]; Region: COG0397 153948005875 hypothetical protein; Validated; Region: PRK00029 153948005876 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 153948005877 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 153948005878 active site 153948005879 metal binding site [ion binding]; metal-binding site 153948005880 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 153948005881 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824 153948005882 putative hydrophobic ligand binding site [chemical binding]; other site 153948005883 Domain of unknown function (DUF3330); Region: DUF3330; pfam11809 153948005884 Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436 153948005885 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 153948005886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948005887 active site 153948005888 phosphorylation site [posttranslational modification] 153948005889 intermolecular recognition site; other site 153948005890 dimerization interface [polypeptide binding]; other site 153948005891 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 153948005892 DNA binding residues [nucleotide binding] 153948005893 dimerization interface [polypeptide binding]; other site 153948005894 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 153948005895 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 153948005896 putative active site [active] 153948005897 heme pocket [chemical binding]; other site 153948005898 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 153948005899 putative active site [active] 153948005900 heme pocket [chemical binding]; other site 153948005901 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 153948005902 dimer interface [polypeptide binding]; other site 153948005903 phosphorylation site [posttranslational modification] 153948005904 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 153948005905 ATP binding site [chemical binding]; other site 153948005906 Mg2+ binding site [ion binding]; other site 153948005907 G-X-G motif; other site 153948005908 Domain of unknown function (DUF897); Region: DUF897; pfam05982 153948005909 Nitrogen regulatory protein P-II; Region: P-II; cl00412 153948005910 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 153948005911 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 153948005912 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 153948005913 active site 153948005914 HIGH motif; other site 153948005915 nucleotide binding site [chemical binding]; other site 153948005916 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 153948005917 active site 153948005918 KMSKS motif; other site 153948005919 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 153948005920 tRNA binding surface [nucleotide binding]; other site 153948005921 anticodon binding site; other site 153948005922 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 153948005923 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 153948005924 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 153948005925 active site 153948005926 Riboflavin kinase; Region: Flavokinase; smart00904 153948005927 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 153948005928 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 153948005929 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 153948005930 Methyltransferase domain; Region: Methyltransf_31; pfam13847 153948005931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 153948005932 S-adenosylmethionine binding site [chemical binding]; other site 153948005933 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 153948005934 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 153948005935 pyridoxal 5'-phosphate binding site [chemical binding]; other site 153948005936 homodimer interface [polypeptide binding]; other site 153948005937 catalytic residue [active] 153948005938 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 153948005939 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 153948005940 metal binding site [ion binding]; metal-binding site 153948005941 dimer interface [polypeptide binding]; other site 153948005942 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 153948005943 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 153948005944 Walker A motif; other site 153948005945 ATP binding site [chemical binding]; other site 153948005946 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 153948005947 Walker B motif; other site 153948005948 arginine finger; other site 153948005949 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 153948005950 ATP-dependent protease subunit HslV; Provisional; Region: PRK05456 153948005951 active site 153948005952 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 153948005953 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 153948005954 active site 153948005955 DNA binding site [nucleotide binding] 153948005956 Int/Topo IB signature motif; other site 153948005957 Protein of unknown function, DUF484; Region: DUF484; cl17449 153948005958 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 153948005959 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 153948005960 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 153948005961 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 153948005962 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 153948005963 Coenzyme A binding pocket [chemical binding]; other site 153948005964 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 153948005965 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 153948005966 Cu(I) binding site [ion binding]; other site 153948005967 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 153948005968 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 153948005969 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 153948005970 Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561 153948005971 Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_2; cd09821 153948005972 putative heme binding site [chemical binding]; other site 153948005973 putative substrate binding site [chemical binding]; other site 153948005974 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 153948005975 Putative transmembrane protein (PGPGW); Region: PGPGW; pfam09656 153948005976 Ammonia monooxygenase/methane monooxygenase, subunit C; Region: AmoC; pfam04896 153948005977 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 153948005978 PBP superfamily domain; Region: PBP_like_2; cl17296 153948005979 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 153948005980 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 153948005981 dimer interface [polypeptide binding]; other site 153948005982 conserved gate region; other site 153948005983 putative PBP binding loops; other site 153948005984 ABC-ATPase subunit interface; other site 153948005985 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 153948005986 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 153948005987 Walker A/P-loop; other site 153948005988 ATP binding site [chemical binding]; other site 153948005989 Q-loop/lid; other site 153948005990 ABC transporter signature motif; other site 153948005991 Walker B; other site 153948005992 D-loop; other site 153948005993 H-loop/switch region; other site 153948005994 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 153948005995 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 153948005996 Walker A/P-loop; other site 153948005997 ATP binding site [chemical binding]; other site 153948005998 Q-loop/lid; other site 153948005999 ABC transporter signature motif; other site 153948006000 Walker B; other site 153948006001 D-loop; other site 153948006002 H-loop/switch region; other site 153948006003 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 153948006004 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 153948006005 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 153948006006 G1 box; other site 153948006007 putative GEF interaction site [polypeptide binding]; other site 153948006008 GTP/Mg2+ binding site [chemical binding]; other site 153948006009 Switch I region; other site 153948006010 G2 box; other site 153948006011 G3 box; other site 153948006012 Switch II region; other site 153948006013 G4 box; other site 153948006014 G5 box; other site 153948006015 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 153948006016 hypothetical protein; Provisional; Region: PRK11820 153948006017 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 153948006018 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 153948006019 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 153948006020 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 153948006021 dimer interface [polypeptide binding]; other site 153948006022 phosphorylation site [posttranslational modification] 153948006023 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 153948006024 ATP binding site [chemical binding]; other site 153948006025 Mg2+ binding site [ion binding]; other site 153948006026 G-X-G motif; other site 153948006027 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 153948006028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948006029 active site 153948006030 phosphorylation site [posttranslational modification] 153948006031 intermolecular recognition site; other site 153948006032 dimerization interface [polypeptide binding]; other site 153948006033 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 153948006034 Walker A motif; other site 153948006035 ATP binding site [chemical binding]; other site 153948006036 Walker B motif; other site 153948006037 arginine finger; other site 153948006038 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 153948006039 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 153948006040 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 153948006041 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 153948006042 oligomer interface [polypeptide binding]; other site 153948006043 metal binding site [ion binding]; metal-binding site 153948006044 metal binding site [ion binding]; metal-binding site 153948006045 Cl binding site [ion binding]; other site 153948006046 aspartate ring; other site 153948006047 putative hydrophobic gate; other site 153948006048 periplasmic entrance; other site 153948006049 Transposase domain (DUF772); Region: DUF772; pfam05598 153948006050 hypothetical protein; Reviewed; Region: PRK12497 153948006051 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 153948006052 putative ligand binding site [chemical binding]; other site 153948006053 Predicted methyltransferases [General function prediction only]; Region: COG0313 153948006054 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 153948006055 putative SAM binding site [chemical binding]; other site 153948006056 putative homodimer interface [polypeptide binding]; other site 153948006057 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 153948006058 active site 153948006059 substrate binding pocket [chemical binding]; other site 153948006060 dimer interface [polypeptide binding]; other site 153948006061 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 153948006062 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 153948006063 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 153948006064 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 153948006065 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 153948006066 homodimer interface [polypeptide binding]; other site 153948006067 substrate-cofactor binding pocket; other site 153948006068 pyridoxal 5'-phosphate binding site [chemical binding]; other site 153948006069 catalytic residue [active] 153948006070 Protein of unknown function (DUF493); Region: DUF493; cl01102 153948006071 lipoate-protein ligase B; Provisional; Region: PRK14342 153948006072 lipoyl synthase; Provisional; Region: PRK05481 153948006073 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 153948006074 FeS/SAM binding site; other site 153948006075 OsmC-like protein; Region: OsmC; cl00767 153948006076 Cytochrome c; Region: Cytochrom_C; cl11414 153948006077 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 153948006078 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 153948006079 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 153948006080 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 153948006081 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 153948006082 putative active site [active] 153948006083 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 153948006084 dimer interface [polypeptide binding]; other site 153948006085 phosphorylation site [posttranslational modification] 153948006086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 153948006087 ATP binding site [chemical binding]; other site 153948006088 Mg2+ binding site [ion binding]; other site 153948006089 G-X-G motif; other site 153948006090 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 153948006091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948006092 active site 153948006093 phosphorylation site [posttranslational modification] 153948006094 intermolecular recognition site; other site 153948006095 dimerization interface [polypeptide binding]; other site 153948006096 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 153948006097 DNA binding site [nucleotide binding] 153948006098 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 153948006099 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 153948006100 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 153948006101 S-adenosylmethionine binding site [chemical binding]; other site 153948006102 putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073 153948006103 Outer membrane lipoprotein Slp family; Region: Slp; pfam03843 153948006104 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 153948006105 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 153948006106 metal binding site [ion binding]; metal-binding site 153948006107 active site 153948006108 I-site; other site 153948006109 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 153948006110 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 153948006111 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183 153948006112 putative active site [active] 153948006113 metal binding site [ion binding]; metal-binding site 153948006114 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 153948006115 active site 153948006116 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 153948006117 Dienelactone hydrolase family; Region: DLH; pfam01738 153948006118 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 153948006119 Domain of unknown function (DUF336); Region: DUF336; pfam03928 153948006120 DNA polymerase III subunit delta'; Validated; Region: PRK06964 153948006121 DNA polymerase III subunit delta'; Validated; Region: PRK08485 153948006122 thymidylate kinase; Validated; Region: tmk; PRK00698 153948006123 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 153948006124 TMP-binding site; other site 153948006125 ATP-binding site [chemical binding]; other site 153948006126 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 153948006127 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 153948006128 amidase catalytic site [active] 153948006129 Zn binding residues [ion binding]; other site 153948006130 substrate binding site [chemical binding]; other site 153948006131 Protein of unknown function (DUF497); Region: DUF497; pfam04365 153948006132 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 153948006133 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 153948006134 active site 153948006135 phosphate binding residues; other site 153948006136 catalytic residues [active] 153948006137 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 153948006138 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 153948006139 ATP-grasp domain; Region: ATP-grasp; pfam02222 153948006140 epoxyqueuosine reductase; Region: TIGR00276 153948006141 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 153948006142 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 153948006143 AMIN domain; Region: AMIN; pfam11741 153948006144 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 153948006145 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 153948006146 active site 153948006147 metal binding site [ion binding]; metal-binding site 153948006148 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 153948006149 Permease; Region: Permease; pfam02405 153948006150 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 153948006151 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 153948006152 Walker A/P-loop; other site 153948006153 ATP binding site [chemical binding]; other site 153948006154 Q-loop/lid; other site 153948006155 ABC transporter signature motif; other site 153948006156 Walker B; other site 153948006157 D-loop; other site 153948006158 H-loop/switch region; other site 153948006159 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 153948006160 mce related protein; Region: MCE; pfam02470 153948006161 Protein of unknown function (DUF330); Region: DUF330; cl01135 153948006162 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 153948006163 diaminopimelate decarboxylase; Region: lysA; TIGR01048 153948006164 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 153948006165 active site 153948006166 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 153948006167 substrate binding site [chemical binding]; other site 153948006168 catalytic residues [active] 153948006169 dimer interface [polypeptide binding]; other site 153948006170 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 153948006171 active site lid residues [active] 153948006172 substrate binding pocket [chemical binding]; other site 153948006173 catalytic residues [active] 153948006174 substrate-Mg2+ binding site; other site 153948006175 aspartate-rich region 1; other site 153948006176 aspartate-rich region 2; other site 153948006177 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 153948006178 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 153948006179 putative NADP binding site [chemical binding]; other site 153948006180 putative substrate binding site [chemical binding]; other site 153948006181 active site 153948006182 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 153948006183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948006184 active site 153948006185 phosphorylation site [posttranslational modification] 153948006186 intermolecular recognition site; other site 153948006187 dimerization interface [polypeptide binding]; other site 153948006188 Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344 153948006189 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 153948006190 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 153948006191 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 153948006192 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 153948006193 active site 153948006194 Zn binding site [ion binding]; other site 153948006195 Predicted membrane protein [Function unknown]; Region: COG1981 153948006196 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 153948006197 non-specific DNA binding site [nucleotide binding]; other site 153948006198 salt bridge; other site 153948006199 sequence-specific DNA binding site [nucleotide binding]; other site 153948006200 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 153948006201 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 153948006202 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 153948006203 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 153948006204 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 153948006205 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 153948006206 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 153948006207 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 153948006208 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 153948006209 PAS domain; Region: PAS_9; pfam13426 153948006210 putative active site [active] 153948006211 heme pocket [chemical binding]; other site 153948006212 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 153948006213 hydrophobic ligand binding site; other site 153948006214 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 153948006215 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 153948006216 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 153948006217 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 153948006218 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 153948006219 active site 153948006220 HIGH motif; other site 153948006221 nucleotide binding site [chemical binding]; other site 153948006222 active site 153948006223 KMSKS motif; other site 153948006224 Transposase; Region: HTH_Tnp_1; cl17663 153948006225 putative transposase OrfB; Reviewed; Region: PHA02517 153948006226 HTH-like domain; Region: HTH_21; pfam13276 153948006227 Integrase core domain; Region: rve; pfam00665 153948006228 Integrase core domain; Region: rve_3; cl15866 153948006229 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 153948006230 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 153948006231 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 153948006232 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 153948006233 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 153948006234 active site 153948006235 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 153948006236 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 153948006237 Multicopper oxidase; Region: Cu-oxidase; pfam00394 153948006238 Glutamate-cysteine ligase; Region: GshA; pfam08886 153948006239 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 153948006240 glutathione synthetase; Provisional; Region: PRK05246 153948006241 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 153948006242 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 153948006243 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 153948006244 active site 153948006245 FtsH Extracellular; Region: FtsH_ext; pfam06480 153948006246 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 153948006247 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 153948006248 Walker A motif; other site 153948006249 ATP binding site [chemical binding]; other site 153948006250 Walker B motif; other site 153948006251 arginine finger; other site 153948006252 Peptidase family M41; Region: Peptidase_M41; pfam01434 153948006253 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349 153948006254 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 153948006255 PAS domain; Region: PAS_9; pfam13426 153948006256 putative active site [active] 153948006257 heme pocket [chemical binding]; other site 153948006258 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 153948006259 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 153948006260 metal binding site [ion binding]; metal-binding site 153948006261 active site 153948006262 I-site; other site 153948006263 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 153948006264 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 153948006265 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 153948006266 ligand binding site [chemical binding]; other site 153948006267 flexible hinge region; other site 153948006268 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 153948006269 Transposase domain (DUF772); Region: DUF772; pfam05598 153948006270 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 153948006271 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 153948006272 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 153948006273 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 153948006274 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 153948006275 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 153948006276 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 153948006277 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 153948006278 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 153948006279 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 153948006280 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 153948006281 active site 153948006282 catalytic residues [active] 153948006283 metal binding site [ion binding]; metal-binding site 153948006284 5'-methylthioadenosine phosphorylase; Validated; Region: PRK09136 153948006285 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 153948006286 active site 153948006287 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 153948006288 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 153948006289 nucleotide binding pocket [chemical binding]; other site 153948006290 K-X-D-G motif; other site 153948006291 catalytic site [active] 153948006292 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 153948006293 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 153948006294 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 153948006295 Dimer interface [polypeptide binding]; other site 153948006296 BRCT sequence motif; other site 153948006297 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 153948006298 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 153948006299 nudix motif; other site 153948006300 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 153948006301 Short C-terminal domain; Region: SHOCT; pfam09851 153948006302 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 153948006303 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 153948006304 elongation factor P; Validated; Region: PRK00529 153948006305 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 153948006306 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 153948006307 RNA binding site [nucleotide binding]; other site 153948006308 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 153948006309 RNA binding site [nucleotide binding]; other site 153948006310 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 153948006311 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 153948006312 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 153948006313 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 153948006314 trimerization site [polypeptide binding]; other site 153948006315 active site 153948006316 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 153948006317 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 153948006318 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 153948006319 catalytic residue [active] 153948006320 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 153948006321 FeS assembly protein SufD; Region: sufD; TIGR01981 153948006322 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 153948006323 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 153948006324 Walker A/P-loop; other site 153948006325 ATP binding site [chemical binding]; other site 153948006326 Q-loop/lid; other site 153948006327 ABC transporter signature motif; other site 153948006328 Walker B; other site 153948006329 D-loop; other site 153948006330 H-loop/switch region; other site 153948006331 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 153948006332 putative ABC transporter; Region: ycf24; CHL00085 153948006333 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 153948006334 Predicted transcriptional regulator [Transcription]; Region: COG1959 153948006335 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 153948006336 putative transposase OrfB; Reviewed; Region: PHA02517 153948006337 HTH-like domain; Region: HTH_21; pfam13276 153948006338 Integrase core domain; Region: rve; pfam00665 153948006339 Integrase core domain; Region: rve_3; cl15866 153948006340 Transposase; Region: HTH_Tnp_1; cl17663 153948006341 transposase/IS protein; Provisional; Region: PRK09183 153948006342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 153948006343 Walker A motif; other site 153948006344 ATP binding site [chemical binding]; other site 153948006345 Walker B motif; other site 153948006346 arginine finger; other site 153948006347 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u3; cd11540 153948006348 putative metal binding site [ion binding]; other site 153948006349 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 153948006350 metal binding site [ion binding]; metal-binding site 153948006351 Transposase domain (DUF772); Region: DUF772; pfam05598 153948006352 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 153948006353 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 153948006354 Helix-turn-helix domain; Region: HTH_38; pfam13936 153948006355 Winged helix-turn helix; Region: HTH_29; pfam13551 153948006356 Homeodomain-like domain; Region: HTH_32; pfam13565 153948006357 Integrase core domain; Region: rve; pfam00665 153948006358 Transposase domain (DUF772); Region: DUF772; pfam05598 153948006359 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 153948006360 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 153948006361 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 153948006362 putative transposase OrfB; Reviewed; Region: PHA02517 153948006363 HTH-like domain; Region: HTH_21; pfam13276 153948006364 Integrase core domain; Region: rve; pfam00665 153948006365 Integrase core domain; Region: rve_3; cl15866 153948006366 Transposase; Region: HTH_Tnp_1; cl17663 153948006367 transposase/IS protein; Provisional; Region: PRK09183 153948006368 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 153948006369 Transposase; Region: DEDD_Tnp_IS110; pfam01548 153948006370 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 153948006371 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 153948006372 putative transposase OrfB; Reviewed; Region: PHA02517 153948006373 HTH-like domain; Region: HTH_21; pfam13276 153948006374 Integrase core domain; Region: rve; pfam00665 153948006375 Integrase core domain; Region: rve_3; cl15866 153948006376 Transposase; Region: HTH_Tnp_1; cl17663 153948006377 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 153948006378 Helix-turn-helix domain; Region: HTH_38; pfam13936 153948006379 Homeodomain-like domain; Region: HTH_32; pfam13565 153948006380 Integrase core domain; Region: rve; pfam00665 153948006381 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 153948006382 salt bridge; other site 153948006383 non-specific DNA binding site [nucleotide binding]; other site 153948006384 sequence-specific DNA binding site [nucleotide binding]; other site 153948006385 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 153948006386 active site 153948006387 DNA binding site [nucleotide binding] 153948006388 Int/Topo IB signature motif; other site 153948006389 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 153948006390 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 153948006391 oligomeric interface; other site 153948006392 putative active site [active] 153948006393 homodimer interface [polypeptide binding]; other site 153948006394 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 153948006395 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 153948006396 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 153948006397 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 153948006398 GAF domain; Region: GAF; pfam01590 153948006399 GAF domain; Region: GAF_2; pfam13185 153948006400 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 153948006401 Zn2+ binding site [ion binding]; other site 153948006402 Mg2+ binding site [ion binding]; other site 153948006403 Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718 153948006404 RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248 153948006405 ATP binding site [chemical binding]; other site 153948006406 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 153948006407 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 153948006408 catalytic residues [active] 153948006409 catalytic nucleophile [active] 153948006410 Recombinase; Region: Recombinase; pfam07508 153948006411 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 153948006412 Transposase domain (DUF772); Region: DUF772; pfam05598 153948006413 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 153948006414 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 153948006415 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 153948006416 Helix-turn-helix domain; Region: HTH_38; pfam13936 153948006417 Homeodomain-like domain; Region: HTH_32; pfam13565 153948006418 Integrase core domain; Region: rve; pfam00665 153948006419 putative transposase OrfB; Reviewed; Region: PHA02517 153948006420 HTH-like domain; Region: HTH_21; pfam13276 153948006421 Integrase core domain; Region: rve; pfam00665 153948006422 Integrase core domain; Region: rve_3; cl15866 153948006423 Transcriptional activator TraM; Region: Activator-TraM; cl11943 153948006424 Helix-turn-helix domain; Region: HTH_17; pfam12728 153948006425 transposase/IS protein; Provisional; Region: PRK09183 153948006426 Putative ATP-dependent Lon protease; Region: Lon_2; cl11979 153948006427 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 153948006428 Walker A motif; other site 153948006429 ATP binding site [chemical binding]; other site 153948006430 Walker B motif; other site 153948006431 arginine finger; other site 153948006432 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 153948006433 Helix-turn-helix domain; Region: HTH_38; pfam13936 153948006434 Integrase core domain; Region: rve; pfam00665 153948006435 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 153948006436 Int/Topo IB signature motif; other site 153948006437 Stringent starvation protein B; Region: SspB; cl01120 153948006438 stringent starvation protein A; Provisional; Region: sspA; PRK09481 153948006439 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 153948006440 C-terminal domain interface [polypeptide binding]; other site 153948006441 putative GSH binding site (G-site) [chemical binding]; other site 153948006442 dimer interface [polypeptide binding]; other site 153948006443 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 153948006444 N-terminal domain interface [polypeptide binding]; other site 153948006445 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 153948006446 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 153948006447 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 153948006448 Qi binding site; other site 153948006449 intrachain domain interface; other site 153948006450 interchain domain interface [polypeptide binding]; other site 153948006451 heme bH binding site [chemical binding]; other site 153948006452 heme bL binding site [chemical binding]; other site 153948006453 Qo binding site; other site 153948006454 interchain domain interface [polypeptide binding]; other site 153948006455 intrachain domain interface; other site 153948006456 Qi binding site; other site 153948006457 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 153948006458 Qo binding site; other site 153948006459 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 153948006460 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 153948006461 [2Fe-2S] cluster binding site [ion binding]; other site 153948006462 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 153948006463 DEAD/DEAH box helicase; Region: DEAD; pfam00270 153948006464 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 153948006465 SEC-C motif; Region: SEC-C; pfam02810 153948006466 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 153948006467 Peptidase family M23; Region: Peptidase_M23; pfam01551 153948006468 Protein of unknown function (DUF721); Region: DUF721; pfam05258 153948006469 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 153948006470 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 153948006471 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 153948006472 RNB domain; Region: RNB; pfam00773 153948006473 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 153948006474 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 153948006475 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 153948006476 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 153948006477 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 153948006478 shikimate binding site; other site 153948006479 NAD(P) binding site [chemical binding]; other site 153948006480 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 153948006481 MgtE intracellular N domain; Region: MgtE_N; smart00924 153948006482 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 153948006483 Divalent cation transporter; Region: MgtE; cl00786 153948006484 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 153948006485 active site 153948006486 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 153948006487 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 153948006488 Methyltransferase domain; Region: Methyltransf_23; pfam13489 153948006489 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 153948006490 S-adenosylmethionine binding site [chemical binding]; other site 153948006491 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 153948006492 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 153948006493 Walker A/P-loop; other site 153948006494 ATP binding site [chemical binding]; other site 153948006495 Q-loop/lid; other site 153948006496 ABC transporter signature motif; other site 153948006497 Walker B; other site 153948006498 D-loop; other site 153948006499 H-loop/switch region; other site 153948006500 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 153948006501 putative carbohydrate binding site [chemical binding]; other site 153948006502 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 153948006503 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 153948006504 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 153948006505 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 153948006506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 153948006507 fumarate hydratase; Reviewed; Region: fumC; PRK00485 153948006508 Class II fumarases; Region: Fumarase_classII; cd01362 153948006509 active site 153948006510 tetramer interface [polypeptide binding]; other site 153948006511 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 153948006512 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 153948006513 non-specific DNA binding site [nucleotide binding]; other site 153948006514 salt bridge; other site 153948006515 sequence-specific DNA binding site [nucleotide binding]; other site 153948006516 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 153948006517 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 153948006518 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 153948006519 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 153948006520 dimer interface [polypeptide binding]; other site 153948006521 putative radical transfer pathway; other site 153948006522 diiron center [ion binding]; other site 153948006523 tyrosyl radical; other site 153948006524 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 153948006525 ATP cone domain; Region: ATP-cone; pfam03477 153948006526 Class I ribonucleotide reductase; Region: RNR_I; cd01679 153948006527 active site 153948006528 dimer interface [polypeptide binding]; other site 153948006529 catalytic residues [active] 153948006530 effector binding site; other site 153948006531 R2 peptide binding site; other site 153948006532 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 153948006533 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 153948006534 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 153948006535 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 153948006536 GIY-YIG motif/motif A; other site 153948006537 active site 153948006538 catalytic site [active] 153948006539 putative DNA binding site [nucleotide binding]; other site 153948006540 metal binding site [ion binding]; metal-binding site 153948006541 UvrB/uvrC motif; Region: UVR; pfam02151 153948006542 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 153948006543 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 153948006544 active site 1 [active] 153948006545 dimer interface [polypeptide binding]; other site 153948006546 hexamer interface [polypeptide binding]; other site 153948006547 active site 2 [active] 153948006548 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 153948006549 Fe-S cluster binding site [ion binding]; other site 153948006550 DNA binding site [nucleotide binding] 153948006551 active site 153948006552 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 153948006553 Putative integral membrane protein DUF46; Region: DUF46; cl17511 153948006554 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 153948006555 putative catalytic site [active] 153948006556 putative metal binding site [ion binding]; other site 153948006557 putative phosphate binding site [ion binding]; other site 153948006558 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 153948006559 Found in ATP-dependent protease La (LON); Region: LON; smart00464 153948006560 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 153948006561 Walker A motif; other site 153948006562 ATP binding site [chemical binding]; other site 153948006563 Walker B motif; other site 153948006564 arginine finger; other site 153948006565 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 153948006566 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 153948006567 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 153948006568 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 153948006569 Walker A motif; other site 153948006570 ATP binding site [chemical binding]; other site 153948006571 Walker B motif; other site 153948006572 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 153948006573 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 153948006574 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 153948006575 oligomer interface [polypeptide binding]; other site 153948006576 active site residues [active] 153948006577 trigger factor; Provisional; Region: tig; PRK01490 153948006578 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 153948006579 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 153948006580 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 153948006581 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 153948006582 NAD(P) binding site [chemical binding]; other site 153948006583 active site 153948006584 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 153948006585 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 153948006586 ring oligomerisation interface [polypeptide binding]; other site 153948006587 ATP/Mg binding site [chemical binding]; other site 153948006588 stacking interactions; other site 153948006589 hinge regions; other site 153948006590 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 153948006591 oligomerisation interface [polypeptide binding]; other site 153948006592 mobile loop; other site 153948006593 roof hairpin; other site 153948006594 Transposase; Region: HTH_Tnp_1; pfam01527 153948006595 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 153948006596 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 153948006597 Helix-turn-helix domain; Region: HTH_38; pfam13936 153948006598 Homeodomain-like domain; Region: HTH_32; pfam13565 153948006599 Integrase core domain; Region: rve; pfam00665 153948006600 putative transposase OrfB; Reviewed; Region: PHA02517 153948006601 HTH-like domain; Region: HTH_21; pfam13276 153948006602 Integrase core domain; Region: rve; pfam00665 153948006603 Integrase core domain; Region: rve_3; pfam13683 153948006604 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 153948006605 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 153948006606 Catalytic site [active] 153948006607 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 153948006608 active site 153948006609 catalytic site [active] 153948006610 substrate binding site [chemical binding]; other site 153948006611 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 153948006612 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 153948006613 GIY-YIG motif/motif A; other site 153948006614 active site 153948006615 catalytic site [active] 153948006616 putative DNA binding site [nucleotide binding]; other site 153948006617 metal binding site [ion binding]; metal-binding site 153948006618 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 153948006619 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 153948006620 active site 153948006621 DNA binding site [nucleotide binding] 153948006622 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 153948006623 transposase/IS protein; Provisional; Region: PRK09183 153948006624 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 153948006625 Walker A motif; other site 153948006626 ATP binding site [chemical binding]; other site 153948006627 Walker B motif; other site 153948006628 arginine finger; other site 153948006629 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 153948006630 Integrase core domain; Region: rve; pfam00665 153948006631 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 153948006632 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 153948006633 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 153948006634 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 153948006635 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 153948006636 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 153948006637 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 153948006638 Phage terminase, small subunit; Region: Terminase_4; pfam05119 153948006639 Phage capsid family; Region: Phage_capsid; pfam05065 153948006640 Bacteriophage replication protein O; Region: Phage_rep_O; cl04545 153948006641 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 153948006642 ParB-like nuclease domain; Region: ParB; smart00470 153948006643 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 153948006644 active site 153948006645 metal binding site [ion binding]; metal-binding site 153948006646 Helix-turn-helix domain; Region: HTH_39; pfam14090 153948006647 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 153948006648 integrase; Provisional; Region: PRK09692 153948006649 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 153948006650 active site 153948006651 Int/Topo IB signature motif; other site 153948006652 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 153948006653 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 153948006654 oligomer interface [polypeptide binding]; other site 153948006655 metal binding site [ion binding]; metal-binding site 153948006656 metal binding site [ion binding]; metal-binding site 153948006657 putative Cl binding site [ion binding]; other site 153948006658 basic sphincter; other site 153948006659 hydrophobic gate; other site 153948006660 periplasmic entrance; other site 153948006661 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 153948006662 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 153948006663 Ligand Binding Site [chemical binding]; other site 153948006664 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 153948006665 nudix motif; other site 153948006666 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 153948006667 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 153948006668 ATP binding site [chemical binding]; other site 153948006669 putative Mg++ binding site [ion binding]; other site 153948006670 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 153948006671 nucleotide binding region [chemical binding]; other site 153948006672 ATP-binding site [chemical binding]; other site 153948006673 Helicase associated domain (HA2); Region: HA2; pfam04408 153948006674 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 153948006675 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 153948006676 Putative addiction module component; Region: Unstab_antitox; pfam09720 153948006677 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 153948006678 Protein of unknown function DUF262; Region: DUF262; pfam03235 153948006679 Uncharacterized conserved protein [Function unknown]; Region: COG1479 153948006680 Uncharacterized conserved protein [Function unknown]; Region: COG3472 153948006681 Transposase; Region: HTH_Tnp_1; cl17663 153948006682 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 153948006683 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 153948006684 putative dimer interface [polypeptide binding]; other site 153948006685 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 153948006686 TfoX C-terminal domain; Region: TfoX_C; pfam04994 153948006687 Staphylococcal nuclease homologues; Region: SNc; smart00318 153948006688 Catalytic site; other site 153948006689 Staphylococcal nuclease homologue; Region: SNase; pfam00565 153948006690 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 153948006691 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 153948006692 C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196 153948006693 putative N-terminal domain interface [polypeptide binding]; other site 153948006694 putative dimer interface [polypeptide binding]; other site 153948006695 putative substrate binding pocket (H-site) [chemical binding]; other site 153948006696 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 153948006697 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 153948006698 putative metal binding site [ion binding]; other site 153948006699 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 153948006700 HSP70 interaction site [polypeptide binding]; other site 153948006701 BolA-like protein; Region: BolA; pfam01722 153948006702 ABC-2 type transporter; Region: ABC2_membrane; cl17235 153948006703 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 153948006704 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 153948006705 Walker A/P-loop; other site 153948006706 ATP binding site [chemical binding]; other site 153948006707 Q-loop/lid; other site 153948006708 ABC transporter signature motif; other site 153948006709 Walker B; other site 153948006710 D-loop; other site 153948006711 H-loop/switch region; other site 153948006712 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 153948006713 anti sigma factor interaction site; other site 153948006714 regulatory phosphorylation site [posttranslational modification]; other site 153948006715 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 153948006716 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 153948006717 mce related protein; Region: MCE; pfam02470 153948006718 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 153948006719 Permease; Region: Permease; cl00510 153948006720 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 153948006721 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 153948006722 Walker A/P-loop; other site 153948006723 ATP binding site [chemical binding]; other site 153948006724 Q-loop/lid; other site 153948006725 ABC transporter signature motif; other site 153948006726 Walker B; other site 153948006727 D-loop; other site 153948006728 H-loop/switch region; other site 153948006729 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 153948006730 Staphylococcal nuclease homologues; Region: SNc; smart00318 153948006731 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 153948006732 Catalytic site; other site 153948006733 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 153948006734 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 153948006735 active site 153948006736 metal binding site [ion binding]; metal-binding site 153948006737 Cytochrome c; Region: Cytochrom_C; pfam00034 153948006738 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 153948006739 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 153948006740 Cytochrome c; Region: Cytochrom_C; pfam00034 153948006741 Cytochrome c; Region: Cytochrom_C; cl11414 153948006742 Cytochrome c; Region: Cytochrom_C; cl11414 153948006743 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 153948006744 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 153948006745 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 153948006746 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 153948006747 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 153948006748 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 153948006749 Soluble P-type ATPase [General function prediction only]; Region: COG4087 153948006750 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 153948006751 Putative phosphatase (DUF442); Region: DUF442; cl17385 153948006752 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 153948006753 Putative phosphatase (DUF442); Region: DUF442; cl17385 153948006754 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 153948006755 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 153948006756 putative DNA binding site [nucleotide binding]; other site 153948006757 dimerization interface [polypeptide binding]; other site 153948006758 putative Zn2+ binding site [ion binding]; other site 153948006759 Predicted transporter component [General function prediction only]; Region: COG2391 153948006760 Sulphur transport; Region: Sulf_transp; pfam04143 153948006761 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 153948006762 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 153948006763 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 153948006764 HSP70 interaction site [polypeptide binding]; other site 153948006765 DnaJ domain; Region: DnaJ; pfam00226 153948006766 HSP70 interaction site [polypeptide binding]; other site 153948006767 Hemin uptake protein hemP; Region: hemP; pfam10636 153948006768 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 153948006769 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 153948006770 heme binding site [chemical binding]; other site 153948006771 ferroxidase pore; other site 153948006772 ferroxidase diiron center [ion binding]; other site 153948006773 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 153948006774 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 153948006775 Integrase core domain; Region: rve; pfam00665 153948006776 transposase/IS protein; Provisional; Region: PRK09183 153948006777 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 153948006778 Walker A motif; other site 153948006779 ATP binding site [chemical binding]; other site 153948006780 Walker B motif; other site 153948006781 arginine finger; other site 153948006782 Transposase IS200 like; Region: Y1_Tnp; pfam01797 153948006783 methane monooxygenase/ammonia monooxygenase, subunit B; Region: CH4_NH3mon_ox_B; TIGR03079 153948006784 Monooxygenase subunit B protein; Region: Monooxygenase_B; pfam04744 153948006785 methane monooxygenase/ammonia monooxygenase, subunit A; Region: CH4_NH3mon_ox_A; TIGR03080 153948006786 Ammonia monooxygenase/methane monooxygenase, subunit C; Region: AmoC; pfam04896 153948006787 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 153948006788 Helix-turn-helix domain; Region: HTH_38; pfam13936 153948006789 Homeodomain-like domain; Region: HTH_32; pfam13565 153948006790 Integrase core domain; Region: rve; pfam00665 153948006791 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 153948006792 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948006793 active site 153948006794 phosphorylation site [posttranslational modification] 153948006795 intermolecular recognition site; other site 153948006796 dimerization interface [polypeptide binding]; other site 153948006797 Cation transport protein; Region: TrkH; cl17365 153948006798 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 153948006799 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 153948006800 TrkA-N domain; Region: TrkA_N; pfam02254 153948006801 TrkA-C domain; Region: TrkA_C; pfam02080 153948006802 TrkA-N domain; Region: TrkA_N; pfam02254 153948006803 TrkA-C domain; Region: TrkA_C; pfam02080 153948006804 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 153948006805 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 153948006806 active site 153948006807 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 153948006808 putative catalytic residue [active] 153948006809 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 153948006810 RNA methyltransferase, RsmE family; Region: TIGR00046 153948006811 N-acetylglutamate synthase; Validated; Region: PRK05279 153948006812 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 153948006813 putative feedback inhibition sensing region; other site 153948006814 putative nucleotide binding site [chemical binding]; other site 153948006815 putative substrate binding site [chemical binding]; other site 153948006816 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 153948006817 Coenzyme A binding pocket [chemical binding]; other site 153948006818 oxidative damage protection protein; Provisional; Region: PRK05408 153948006819 Family description; Region: VCBS; pfam13517 153948006820 Family description; Region: VCBS; pfam13517 153948006821 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 153948006822 AAA domain; Region: AAA_32; pfam13654 153948006823 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 153948006824 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 153948006825 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 153948006826 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 153948006827 active site 153948006828 Protoglobin; Region: Protoglobin; pfam11563 153948006829 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 153948006830 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 153948006831 nucleotide binding site [chemical binding]; other site 153948006832 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 153948006833 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 153948006834 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 153948006835 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 153948006836 active site 153948006837 catalytic site [active] 153948006838 metal binding site [ion binding]; metal-binding site 153948006839 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 153948006840 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 153948006841 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 153948006842 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 153948006843 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 153948006844 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 153948006845 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 153948006846 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 153948006847 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 153948006848 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 153948006849 ZIP Zinc transporter; Region: Zip; pfam02535 153948006850 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 153948006851 Protein of unknown function (DUF4019); Region: DUF4019; pfam13211 153948006852 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 153948006853 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 153948006854 putative substrate translocation pore; other site 153948006855 putative transposase OrfB; Reviewed; Region: PHA02517 153948006856 HTH-like domain; Region: HTH_21; pfam13276 153948006857 Integrase core domain; Region: rve; pfam00665 153948006858 Integrase core domain; Region: rve_3; cl15866 153948006859 Transposase; Region: HTH_Tnp_1; cl17663 153948006860 Transposase domain (DUF772); Region: DUF772; pfam05598 153948006861 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 153948006862 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 153948006863 Transposase; Region: HTH_Tnp_1; cl17663 153948006864 putative transposase OrfB; Reviewed; Region: PHA02517 153948006865 HTH-like domain; Region: HTH_21; pfam13276 153948006866 Integrase core domain; Region: rve; pfam00665 153948006867 Integrase core domain; Region: rve_3; cl15866 153948006868 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 153948006869 Integrase core domain; Region: rve; pfam00665 153948006870 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 153948006871 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 153948006872 putative C-terminal domain interface [polypeptide binding]; other site 153948006873 putative GSH binding site (G-site) [chemical binding]; other site 153948006874 putative dimer interface [polypeptide binding]; other site 153948006875 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 153948006876 N-terminal domain interface [polypeptide binding]; other site 153948006877 dimer interface [polypeptide binding]; other site 153948006878 substrate binding pocket (H-site) [chemical binding]; other site 153948006879 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 153948006880 ATP binding site [chemical binding]; other site 153948006881 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 153948006882 dimer interface [polypeptide binding]; other site 153948006883 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 153948006884 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 153948006885 Walker A/P-loop; other site 153948006886 ATP binding site [chemical binding]; other site 153948006887 Q-loop/lid; other site 153948006888 ABC transporter signature motif; other site 153948006889 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 153948006890 Walker B; other site 153948006891 D-loop; other site 153948006892 ABC transporter; Region: ABC_tran_2; pfam12848 153948006893 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 153948006894 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 153948006895 Transposase; Region: HTH_Tnp_1; pfam01527 153948006896 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 153948006897 Helix-turn-helix domain; Region: HTH_38; pfam13936 153948006898 Homeodomain-like domain; Region: HTH_32; pfam13565 153948006899 Integrase core domain; Region: rve; pfam00665 153948006900 transposase/IS protein; Provisional; Region: PRK09183 153948006901 Putative ATP-dependent Lon protease; Region: Lon_2; cl11979 153948006902 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 153948006903 Walker A motif; other site 153948006904 ATP binding site [chemical binding]; other site 153948006905 Walker B motif; other site 153948006906 arginine finger; other site 153948006907 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 153948006908 Helix-turn-helix domain; Region: HTH_38; pfam13936 153948006909 Integrase core domain; Region: rve; pfam00665 153948006910 putative GTP cyclohydrolase; Provisional; Region: PRK13674 153948006911 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 153948006912 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 153948006913 TPP-binding site; other site 153948006914 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 153948006915 PYR/PP interface [polypeptide binding]; other site 153948006916 dimer interface [polypeptide binding]; other site 153948006917 TPP binding site [chemical binding]; other site 153948006918 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 153948006919 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 153948006920 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 153948006921 substrate binding pocket [chemical binding]; other site 153948006922 chain length determination region; other site 153948006923 substrate-Mg2+ binding site; other site 153948006924 catalytic residues [active] 153948006925 aspartate-rich region 1; other site 153948006926 active site lid residues [active] 153948006927 aspartate-rich region 2; other site 153948006928 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 153948006929 MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804 153948006930 active site 153948006931 Predicted permeases [General function prediction only]; Region: COG0795 153948006932 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 153948006933 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 153948006934 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 153948006935 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 153948006936 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 153948006937 Protein of unknown function (DUF2959); Region: DUF2959; pfam11172 153948006938 YaeQ protein; Region: YaeQ; pfam07152 153948006939 Uncharacterized conserved protein [Function unknown]; Region: COG3189 153948006940 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 153948006941 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 153948006942 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 153948006943 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 153948006944 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 153948006945 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 153948006946 Zn2+ binding site [ion binding]; other site 153948006947 Mg2+ binding site [ion binding]; other site 153948006948 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 153948006949 metal binding site [ion binding]; metal-binding site 153948006950 active site 153948006951 I-site; other site 153948006952 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 153948006953 PEP-CTERM motif; Region: VPEP; pfam07589 153948006954 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 153948006955 Helix-turn-helix domain; Region: HTH_38; pfam13936 153948006956 Homeodomain-like domain; Region: HTH_32; pfam13565 153948006957 Integrase core domain; Region: rve; pfam00665 153948006958 Predicted chitinase [General function prediction only]; Region: COG3179 153948006959 catalytic residue [active] 153948006960 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 153948006961 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 153948006962 ATP binding site [chemical binding]; other site 153948006963 Mg2+ binding site [ion binding]; other site 153948006964 G-X-G motif; other site 153948006965 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 153948006966 ATP binding site [chemical binding]; other site 153948006967 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 153948006968 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 153948006969 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 153948006970 putative ligand binding site [chemical binding]; other site 153948006971 putative NAD binding site [chemical binding]; other site 153948006972 catalytic site [active] 153948006973 YHS domain; Region: YHS; pfam04945 153948006974 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 153948006975 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 153948006976 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 153948006977 motif II; other site 153948006978 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 153948006979 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 153948006980 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 153948006981 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 153948006982 putative active site [active] 153948006983 metal binding site [ion binding]; metal-binding site 153948006984 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 153948006985 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 153948006986 FAD binding domain; Region: FAD_binding_4; pfam01565 153948006987 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 153948006988 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 153948006989 catalytic Zn binding site [ion binding]; other site 153948006990 NAD binding site [chemical binding]; other site 153948006991 structural Zn binding site [ion binding]; other site 153948006992 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 153948006993 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 153948006994 NAD(P) binding site [chemical binding]; other site 153948006995 catalytic residues [active] 153948006996 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 153948006997 Domain of unknown function DUF20; Region: UPF0118; pfam01594 153948006998 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 153948006999 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 153948007000 tetramer interface [polypeptide binding]; other site 153948007001 heme binding pocket [chemical binding]; other site 153948007002 NADPH binding site [chemical binding]; other site 153948007003 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 153948007004 DNA-binding site [nucleotide binding]; DNA binding site 153948007005 RNA-binding motif; other site 153948007006 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 153948007007 heterotetramer interface [polypeptide binding]; other site 153948007008 active site pocket [active] 153948007009 cleavage site 153948007010 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 153948007011 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 153948007012 Walker A motif; other site 153948007013 ATP binding site [chemical binding]; other site 153948007014 Walker B motif; other site 153948007015 arginine finger; other site 153948007016 hypothetical protein; Provisional; Region: PRK08999 153948007017 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 153948007018 active site 153948007019 8-oxo-dGMP binding site [chemical binding]; other site 153948007020 nudix motif; other site 153948007021 metal binding site [ion binding]; metal-binding site 153948007022 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 153948007023 thiamine phosphate binding site [chemical binding]; other site 153948007024 active site 153948007025 pyrophosphate binding site [ion binding]; other site 153948007026 Protein of unknown function, DUF484; Region: DUF484; cl17449 153948007027 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 153948007028 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 153948007029 metal binding site [ion binding]; metal-binding site 153948007030 active site 153948007031 I-site; other site 153948007032 Domain of unknown function (DUF329); Region: DUF329; pfam03884 153948007033 RNA polymerase factor sigma-70; Validated; Region: PRK09047 153948007034 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 153948007035 DNA binding residues [nucleotide binding] 153948007036 Protein of unknown function (DUF3619); Region: DUF3619; pfam12279 153948007037 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 153948007038 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 153948007039 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 153948007040 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 153948007041 Walker A/P-loop; other site 153948007042 ATP binding site [chemical binding]; other site 153948007043 Q-loop/lid; other site 153948007044 ABC transporter signature motif; other site 153948007045 Walker B; other site 153948007046 D-loop; other site 153948007047 H-loop/switch region; other site 153948007048 Domain of unknown function (DUF1854); Region: DUF1854; pfam08909 153948007049 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 153948007050 Transposase domain (DUF772); Region: DUF772; pfam05598 153948007051 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 153948007052 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 153948007053 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 153948007054 GTP/Mg2+ binding site [chemical binding]; other site 153948007055 G4 box; other site 153948007056 G5 box; other site 153948007057 trmE is a tRNA modification GTPase; Region: trmE; cd04164 153948007058 G1 box; other site 153948007059 G1 box; other site 153948007060 GTP/Mg2+ binding site [chemical binding]; other site 153948007061 Switch I region; other site 153948007062 Switch I region; other site 153948007063 G2 box; other site 153948007064 G2 box; other site 153948007065 Switch II region; other site 153948007066 G3 box; other site 153948007067 G3 box; other site 153948007068 Switch II region; other site 153948007069 G4 box; other site 153948007070 G5 box; other site 153948007071 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 153948007072 membrane protein insertase; Provisional; Region: PRK01318 153948007073 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 153948007074 Ribonuclease P; Region: Ribonuclease_P; cl00457 153948007075 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 153948007076 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 153948007077 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 153948007078 generic binding surface II; other site 153948007079 generic binding surface I; other site 153948007080 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 153948007081 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 153948007082 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 153948007083 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 153948007084 active site 153948007085 Int/Topo IB signature motif; other site 153948007086 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 153948007087 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 153948007088 DNA binding site [nucleotide binding] 153948007089 active site 153948007090 Transposase domain (DUF772); Region: DUF772; pfam05598 153948007091 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 153948007092 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 153948007093 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 153948007094 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 153948007095 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 153948007096 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 153948007097 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 153948007098 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 153948007099 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 153948007100 NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455 153948007101 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 153948007102 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 153948007103 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 153948007104 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 153948007105 4Fe-4S binding domain; Region: Fer4; pfam00037 153948007106 4Fe-4S binding domain; Region: Fer4; pfam00037 153948007107 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 153948007108 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 153948007109 NADH dehydrogenase subunit G; Validated; Region: PRK09129 153948007110 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 153948007111 catalytic loop [active] 153948007112 iron binding site [ion binding]; other site 153948007113 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 153948007114 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 153948007115 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 153948007116 SLBB domain; Region: SLBB; pfam10531 153948007117 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 153948007118 NADH dehydrogenase subunit E; Validated; Region: PRK07539 153948007119 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 153948007120 putative dimer interface [polypeptide binding]; other site 153948007121 [2Fe-2S] cluster binding site [ion binding]; other site 153948007122 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 153948007123 NADH dehydrogenase subunit D; Validated; Region: PRK06075 153948007124 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 153948007125 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 153948007126 NADH dehydrogenase subunit B; Validated; Region: PRK06411 153948007127 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 153948007128 triosephosphate isomerase; Provisional; Region: PRK14567 153948007129 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 153948007130 substrate binding site [chemical binding]; other site 153948007131 dimer interface [polypeptide binding]; other site 153948007132 catalytic triad [active] 153948007133 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14252 153948007134 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 153948007135 Walker A/P-loop; other site 153948007136 ATP binding site [chemical binding]; other site 153948007137 Q-loop/lid; other site 153948007138 ABC transporter signature motif; other site 153948007139 Walker B; other site 153948007140 D-loop; other site 153948007141 H-loop/switch region; other site 153948007142 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 153948007143 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 153948007144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 153948007145 dimer interface [polypeptide binding]; other site 153948007146 conserved gate region; other site 153948007147 putative PBP binding loops; other site 153948007148 ABC-ATPase subunit interface; other site 153948007149 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 153948007150 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 153948007151 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 153948007152 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 153948007153 Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447 153948007154 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 153948007155 catalytic core [active] 153948007156 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 153948007157 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 153948007158 Peptidase family M23; Region: Peptidase_M23; pfam01551 153948007159 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 153948007160 C-terminal peptidase (prc); Region: prc; TIGR00225 153948007161 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 153948007162 protein binding site [polypeptide binding]; other site 153948007163 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 153948007164 Catalytic dyad [active] 153948007165 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 153948007166 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 153948007167 ATP binding site [chemical binding]; other site 153948007168 substrate interface [chemical binding]; other site 153948007169 division inhibitor protein; Provisional; Region: slmA; PRK09480 153948007170 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 153948007171 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 153948007172 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 153948007173 dimer interface [polypeptide binding]; other site 153948007174 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 153948007175 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 153948007176 glycogen synthase; Provisional; Region: glgA; PRK00654 153948007177 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 153948007178 ADP-binding pocket [chemical binding]; other site 153948007179 homodimer interface [polypeptide binding]; other site 153948007180 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 153948007181 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 153948007182 active site 153948007183 dimer interface [polypeptide binding]; other site 153948007184 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 153948007185 dimer interface [polypeptide binding]; other site 153948007186 active site 153948007187 N-terminal catalytic domain of 4-alpha-glucanotransferase; glycoside hydrolase family 57 (GH57); Region: GH57N_TLGT_like; cd10793 153948007188 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 153948007189 active site 153948007190 catalytic site [active] 153948007191 homodimer interface [polypeptide binding]; other site 153948007192 Lid 1; other site 153948007193 Domain of unknown function (DUF1925); Region: DUF1925; pfam09094 153948007194 Domain of unknown function (DUF1926); Region: DUF1926; pfam09095 153948007195 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 153948007196 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 153948007197 putative active site [active] 153948007198 catalytic site [active] 153948007199 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 153948007200 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 153948007201 ligand binding site; other site 153948007202 oligomer interface; other site 153948007203 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 153948007204 dimer interface [polypeptide binding]; other site 153948007205 N-terminal domain interface [polypeptide binding]; other site 153948007206 sulfate 1 binding site; other site 153948007207 glycogen branching enzyme; Provisional; Region: PRK05402 153948007208 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 153948007209 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 153948007210 active site 153948007211 catalytic site [active] 153948007212 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 153948007213 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 153948007214 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 153948007215 Cytochrome P450; Region: p450; cl12078 153948007216 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 153948007217 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 153948007218 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 153948007219 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 153948007220 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 153948007221 ligand binding site [chemical binding]; other site 153948007222 flexible hinge region; other site 153948007223 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 153948007224 non-specific DNA interactions [nucleotide binding]; other site 153948007225 DNA binding site [nucleotide binding] 153948007226 sequence specific DNA binding site [nucleotide binding]; other site 153948007227 putative cAMP binding site [chemical binding]; other site 153948007228 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 153948007229 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 153948007230 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 153948007231 putative heme binding pocket [chemical binding]; other site 153948007232 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 153948007233 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 153948007234 CsbD-like; Region: CsbD; cl17424 153948007235 CsbD-like; Region: CsbD; cl17424 153948007236 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 153948007237 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 153948007238 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 153948007239 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 153948007240 N-acetyl-D-glucosamine binding site [chemical binding]; other site 153948007241 catalytic residue [active] 153948007242 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 153948007243 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 153948007244 NAD(P) binding site [chemical binding]; other site 153948007245 catalytic residues [active] 153948007246 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 153948007247 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 153948007248 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 153948007249 active site 153948007250 catalytic site [active] 153948007251 substrate binding site [chemical binding]; other site 153948007252 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 153948007253 RNA/DNA hybrid binding site [nucleotide binding]; other site 153948007254 active site 153948007255 Methyltransferase domain; Region: Methyltransf_11; pfam08241 153948007256 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 153948007257 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 153948007258 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 153948007259 active site 153948007260 HIGH motif; other site 153948007261 nucleotide binding site [chemical binding]; other site 153948007262 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 153948007263 KMSKS motif; other site 153948007264 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 153948007265 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 153948007266 23S rRNA interface [nucleotide binding]; other site 153948007267 L3 interface [polypeptide binding]; other site 153948007268 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 153948007269 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 153948007270 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 153948007271 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 153948007272 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 153948007273 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 153948007274 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 153948007275 putative peptidase; Provisional; Region: PRK11649 153948007276 3-oxo-5-alpha-steroid 4-dehydrogenase; Region: Steroid_dh; cl17474 153948007277 Peptidase family M23; Region: Peptidase_M23; pfam01551 153948007278 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 153948007279 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 153948007280 active site 153948007281 HIGH motif; other site 153948007282 dimer interface [polypeptide binding]; other site 153948007283 KMSKS motif; other site 153948007284 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 153948007285 RNA binding surface [nucleotide binding]; other site 153948007286 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 153948007287 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 153948007288 ATP binding site [chemical binding]; other site 153948007289 Mg++ binding site [ion binding]; other site 153948007290 motif III; other site 153948007291 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 153948007292 nucleotide binding region [chemical binding]; other site 153948007293 ATP-binding site [chemical binding]; other site 153948007294 PAS fold; Region: PAS_4; pfam08448 153948007295 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 153948007296 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 153948007297 putative active site [active] 153948007298 heme pocket [chemical binding]; other site 153948007299 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 153948007300 dimer interface [polypeptide binding]; other site 153948007301 phosphorylation site [posttranslational modification] 153948007302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 153948007303 ATP binding site [chemical binding]; other site 153948007304 Mg2+ binding site [ion binding]; other site 153948007305 G-X-G motif; other site 153948007306 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 153948007307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948007308 active site 153948007309 phosphorylation site [posttranslational modification] 153948007310 intermolecular recognition site; other site 153948007311 dimerization interface [polypeptide binding]; other site 153948007312 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 153948007313 DNA binding residues [nucleotide binding] 153948007314 dimerization interface [polypeptide binding]; other site 153948007315 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 153948007316 putative lipid kinase; Reviewed; Region: PRK13057 153948007317 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 153948007318 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 153948007319 active site 153948007320 metal binding site [ion binding]; metal-binding site 153948007321 Ammonia monooxygenase/methane monooxygenase, subunit C; Region: AmoC; pfam04896 153948007322 Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436 153948007323 malate dehydrogenase; Provisional; Region: PRK05442 153948007324 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 153948007325 NAD(P) binding site [chemical binding]; other site 153948007326 dimer interface [polypeptide binding]; other site 153948007327 malate binding site [chemical binding]; other site 153948007328 Transglycosylase SLT domain; Region: SLT_2; pfam13406 153948007329 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 153948007330 N-acetyl-D-glucosamine binding site [chemical binding]; other site 153948007331 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 153948007332 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 153948007333 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 153948007334 metal binding site 2 [ion binding]; metal-binding site 153948007335 putative DNA binding helix; other site 153948007336 metal binding site 1 [ion binding]; metal-binding site 153948007337 dimer interface [polypeptide binding]; other site 153948007338 structural Zn2+ binding site [ion binding]; other site 153948007339 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 153948007340 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 153948007341 dihydrodipicolinate reductase; Provisional; Region: PRK00048 153948007342 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 153948007343 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 153948007344 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 153948007345 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 153948007346 active site 153948007347 metal binding site [ion binding]; metal-binding site 153948007348 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 153948007349 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 153948007350 putative acyl-acceptor binding pocket; other site 153948007351 Nitrogen regulatory protein P-II; Region: P-II; cl00412 153948007352 Domain of unknown function (DUF897); Region: DUF897; pfam05982 153948007353 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 153948007354 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 153948007355 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 153948007356 dimer interface [polypeptide binding]; other site 153948007357 phosphorylation site [posttranslational modification] 153948007358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 153948007359 ATP binding site [chemical binding]; other site 153948007360 Mg2+ binding site [ion binding]; other site 153948007361 G-X-G motif; other site 153948007362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948007363 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 153948007364 active site 153948007365 phosphorylation site [posttranslational modification] 153948007366 intermolecular recognition site; other site 153948007367 dimerization interface [polypeptide binding]; other site 153948007368 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 153948007369 DNA binding site [nucleotide binding] 153948007370 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 153948007371 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 153948007372 substrate binding site [chemical binding]; other site 153948007373 active site 153948007374 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 153948007375 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 153948007376 Zn2+ binding site [ion binding]; other site 153948007377 Mg2+ binding site [ion binding]; other site 153948007378 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 153948007379 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 153948007380 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 153948007381 ADP binding site [chemical binding]; other site 153948007382 magnesium binding site [ion binding]; other site 153948007383 putative shikimate binding site; other site 153948007384 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 153948007385 active site 153948007386 dimer interface [polypeptide binding]; other site 153948007387 metal binding site [ion binding]; metal-binding site 153948007388 TIGR03032 family protein; Region: TIGR03032 153948007389 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 153948007390 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 153948007391 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 153948007392 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 153948007393 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 153948007394 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 153948007395 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 153948007396 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 153948007397 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 153948007398 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 153948007399 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 153948007400 FG-GAP repeat; Region: FG-GAP; cl15299 153948007401 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 153948007402 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 153948007403 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 153948007404 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 153948007405 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 153948007406 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 153948007407 FG-GAP repeat; Region: FG-GAP; cl15299 153948007408 Family description; Region: VCBS; pfam13517 153948007409 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 153948007410 FG-GAP repeat; Region: FG-GAP; cl15299 153948007411 potential frameshift: common BLAST hit: gi|81300146|ref|YP_400354.1| Integrins alpha chain 153948007412 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 153948007413 FG-GAP repeat; Region: FG-GAP; cl15299 153948007414 FG-GAP repeat; Region: FG-GAP; cl15299 153948007415 potential frameshift: common BLAST hit: gi|81300146|ref|YP_400354.1| Integrins alpha chain 153948007416 FG-GAP repeat; Region: FG-GAP; cl15299 153948007417 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 153948007418 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 153948007419 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 153948007420 FG-GAP repeat; Region: FG-GAP; cl15299 153948007421 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 153948007422 FG-GAP repeat; Region: FG-GAP; cl15299 153948007423 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 153948007424 FG-GAP repeat; Region: FG-GAP; cl15299 153948007425 FG-GAP repeat; Region: FG-GAP; cl15299 153948007426 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 153948007427 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 153948007428 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 153948007429 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 153948007430 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 153948007431 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 153948007432 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 153948007433 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 153948007434 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 153948007435 HlyD family secretion protein; Region: HlyD_3; pfam13437 153948007436 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 153948007437 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 153948007438 Multicopper oxidase; Region: Cu-oxidase; pfam00394 153948007439 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 153948007440 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 153948007441 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 153948007442 HSP70 interaction site [polypeptide binding]; other site 153948007443 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 153948007444 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 153948007445 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 153948007446 catalytic nucleophile [active] 153948007447 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 153948007448 Uncharacterized conserved protein [Function unknown]; Region: COG3025 153948007449 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 153948007450 putative active site [active] 153948007451 putative metal binding residues [ion binding]; other site 153948007452 signature motif; other site 153948007453 putative triphosphate binding site [ion binding]; other site 153948007454 CHAD domain; Region: CHAD; pfam05235 153948007455 E3 Ubiquitin ligase; Region: GIDE; pfam12483 153948007456 LemA family; Region: LemA; cl00742 153948007457 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 153948007458 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 153948007459 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 153948007460 ligand binding site [chemical binding]; other site 153948007461 flexible hinge region; other site 153948007462 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 153948007463 putative switch regulator; other site 153948007464 non-specific DNA interactions [nucleotide binding]; other site 153948007465 DNA binding site [nucleotide binding] 153948007466 sequence specific DNA binding site [nucleotide binding]; other site 153948007467 putative cAMP binding site [chemical binding]; other site 153948007468 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 153948007469 GAF domain; Region: GAF; pfam01590 153948007470 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 153948007471 PAS domain; Region: PAS_9; pfam13426 153948007472 putative active site [active] 153948007473 heme pocket [chemical binding]; other site 153948007474 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 153948007475 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 153948007476 metal binding site [ion binding]; metal-binding site 153948007477 active site 153948007478 I-site; other site 153948007479 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 153948007480 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 153948007481 CPxP motif; other site 153948007482 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 153948007483 L-lactate permease; Region: Lactate_perm; cl00701 153948007484 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 153948007485 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 153948007486 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 153948007487 cyclase homology domain; Region: CHD; cd07302 153948007488 nucleotidyl binding site; other site 153948007489 metal binding site [ion binding]; metal-binding site 153948007490 dimer interface [polypeptide binding]; other site 153948007491 FecR protein; Region: FecR; pfam04773 153948007492 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 153948007493 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 153948007494 TPR motif; other site 153948007495 binding surface 153948007496 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 153948007497 binding surface 153948007498 TPR motif; other site 153948007499 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 153948007500 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 153948007501 FecR protein; Region: FecR; pfam04773 153948007502 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 153948007503 binding surface 153948007504 TPR motif; other site 153948007505 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 153948007506 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 153948007507 TPR motif; other site 153948007508 binding surface 153948007509 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 153948007510 binding surface 153948007511 TPR motif; other site 153948007512 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 153948007513 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 153948007514 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 153948007515 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 153948007516 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 153948007517 catalytic residue [active] 153948007518 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 153948007519 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 153948007520 active site 153948007521 metal-binding site 153948007522 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 153948007523 nucleotide binding site/active site [active] 153948007524 HIT family signature motif; other site 153948007525 catalytic residue [active] 153948007526 Fatty acid desaturase; Region: FA_desaturase; pfam00487 153948007527 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 153948007528 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 153948007529 catalytic core [active] 153948007530 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 153948007531 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 153948007532 putative active site [active] 153948007533 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 153948007534 DNA methylase; Region: N6_N4_Mtase; pfam01555 153948007535 putative transposase OrfB; Reviewed; Region: PHA02517 153948007536 HTH-like domain; Region: HTH_21; pfam13276 153948007537 Integrase core domain; Region: rve; pfam00665 153948007538 Integrase core domain; Region: rve_3; cl15866 153948007539 Transposase; Region: HTH_Tnp_1; cl17663 153948007540 Uncharacterized conserved protein [Function unknown]; Region: COG5316 153948007541 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 153948007542 Protein of unknown function (DUF454); Region: DUF454; pfam04304 153948007543 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 153948007544 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 153948007545 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 153948007546 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 153948007547 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 153948007548 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 153948007549 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 153948007550 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 153948007551 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 153948007552 PilX N-terminal; Region: PilX_N; pfam14341 153948007553 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 153948007554 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 153948007555 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 153948007556 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 153948007557 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 153948007558 Type II transport protein GspH; Region: GspH; pfam12019 153948007559 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 153948007560 hydroxyglutarate oxidase; Provisional; Region: PRK11728 153948007561 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 153948007562 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 153948007563 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 153948007564 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 153948007565 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 153948007566 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 153948007567 ATP binding site [chemical binding]; other site 153948007568 G-X-G motif; other site 153948007569 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 153948007570 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948007571 active site 153948007572 phosphorylation site [posttranslational modification] 153948007573 intermolecular recognition site; other site 153948007574 dimerization interface [polypeptide binding]; other site 153948007575 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 153948007576 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 153948007577 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 153948007578 catalytic motif [active] 153948007579 Zn binding site [ion binding]; other site 153948007580 RibD C-terminal domain; Region: RibD_C; cl17279 153948007581 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 153948007582 ATP cone domain; Region: ATP-cone; pfam03477 153948007583 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 153948007584 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 153948007585 dimer interface [polypeptide binding]; other site 153948007586 active site 153948007587 glycine-pyridoxal phosphate binding site [chemical binding]; other site 153948007588 folate binding site [chemical binding]; other site 153948007589 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 153948007590 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 153948007591 catalytic triad [active] 153948007592 Protein of unknown function (DUF2868); Region: DUF2868; pfam11067 153948007593 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 153948007594 G1 box; other site 153948007595 GTP/Mg2+ binding site [chemical binding]; other site 153948007596 G2 box; other site 153948007597 Switch I region; other site 153948007598 G3 box; other site 153948007599 Switch II region; other site 153948007600 G4 box; other site 153948007601 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 153948007602 G5 box; other site 153948007603 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 153948007604 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 153948007605 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 153948007606 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 153948007607 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 153948007608 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 153948007609 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 153948007610 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 153948007611 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 153948007612 Walker A motif; other site 153948007613 ATP binding site [chemical binding]; other site 153948007614 Walker B motif; other site 153948007615 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 153948007616 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 153948007617 Secretin and TonB N terminus short domain; Region: STN; smart00965 153948007618 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 153948007619 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 153948007620 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 153948007621 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 153948007622 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 153948007623 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 153948007624 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 153948007625 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 153948007626 homotrimer interaction site [polypeptide binding]; other site 153948007627 putative active site [active] 153948007628 exonuclease I; Provisional; Region: sbcB; PRK11779 153948007629 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 153948007630 active site 153948007631 catalytic site [active] 153948007632 substrate binding site [chemical binding]; other site 153948007633 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 153948007634 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 153948007635 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 153948007636 Walker A motif; other site 153948007637 ATP binding site [chemical binding]; other site 153948007638 Walker B motif; other site 153948007639 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 153948007640 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 153948007641 Walker A motif; other site 153948007642 ATP binding site [chemical binding]; other site 153948007643 Walker B motif; other site 153948007644 Double zinc ribbon; Region: DZR; pfam12773 153948007645 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 153948007646 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 153948007647 motif 1; other site 153948007648 active site 153948007649 motif 2; other site 153948007650 motif 3; other site 153948007651 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 153948007652 DHHA1 domain; Region: DHHA1; pfam02272 153948007653 recombination regulator RecX; Reviewed; Region: recX; PRK00117 153948007654 recombinase A; Provisional; Region: recA; PRK09354 153948007655 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 153948007656 hexamer interface [polypeptide binding]; other site 153948007657 Walker A motif; other site 153948007658 ATP binding site [chemical binding]; other site 153948007659 Walker B motif; other site 153948007660 adenylate kinase; Reviewed; Region: adk; PRK00279 153948007661 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 153948007662 AMP-binding site [chemical binding]; other site 153948007663 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 153948007664 6-phosphofructokinase; Provisional; Region: PRK14072 153948007665 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 153948007666 active site 153948007667 ADP/pyrophosphate binding site [chemical binding]; other site 153948007668 dimerization interface [polypeptide binding]; other site 153948007669 allosteric effector site; other site 153948007670 fructose-1,6-bisphosphate binding site; other site 153948007671 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 153948007672 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 153948007673 PEP synthetase regulatory protein; Provisional; Region: PRK05339 153948007674 phosphoenolpyruvate synthase; Validated; Region: PRK06464 153948007675 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 153948007676 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 153948007677 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 153948007678 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 153948007679 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 153948007680 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 153948007681 putative dimerization interface [polypeptide binding]; other site 153948007682 ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040 153948007683 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 153948007684 homodimer interface [polypeptide binding]; other site 153948007685 active site 153948007686 heterodimer interface [polypeptide binding]; other site 153948007687 catalytic residue [active] 153948007688 metal binding site [ion binding]; metal-binding site 153948007689 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 153948007690 multimerization interface [polypeptide binding]; other site 153948007691 probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880 153948007692 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 153948007693 Walker A motif; other site 153948007694 ATP binding site [chemical binding]; other site 153948007695 Walker B motif; other site 153948007696 arginine finger; other site 153948007697 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 153948007698 intersubunit interface [polypeptide binding]; other site 153948007699 active site 153948007700 zinc binding site [ion binding]; other site 153948007701 Na+ binding site [ion binding]; other site 153948007702 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 153948007703 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 153948007704 ligand binding site [chemical binding]; other site 153948007705 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442 153948007706 Transposase domain (DUF772); Region: DUF772; pfam05598 153948007707 CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865 153948007708 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 153948007709 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 153948007710 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 153948007711 NAD(P) binding site [chemical binding]; other site 153948007712 catalytic residues [active] 153948007713 putative transposase OrfB; Reviewed; Region: PHA02517 153948007714 HTH-like domain; Region: HTH_21; pfam13276 153948007715 Integrase core domain; Region: rve; pfam00665 153948007716 Integrase core domain; Region: rve_3; cl15866 153948007717 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 153948007718 Helix-turn-helix domain; Region: HTH_38; pfam13936 153948007719 Homeodomain-like domain; Region: HTH_32; pfam13565 153948007720 Integrase core domain; Region: rve; pfam00665 153948007721 Transposase; Region: HTH_Tnp_1; cl17663 153948007722 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 153948007723 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 153948007724 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 153948007725 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 153948007726 agmatinase; Region: agmatinase; TIGR01230 153948007727 oligomer interface [polypeptide binding]; other site 153948007728 putative active site [active] 153948007729 Mn binding site [ion binding]; other site 153948007730 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 153948007731 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 153948007732 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 153948007733 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 153948007734 ligand binding site [chemical binding]; other site 153948007735 flexible hinge region; other site 153948007736 putative switch regulator; other site 153948007737 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 153948007738 non-specific DNA interactions [nucleotide binding]; other site 153948007739 DNA binding site [nucleotide binding] 153948007740 sequence specific DNA binding site [nucleotide binding]; other site 153948007741 putative cAMP binding site [chemical binding]; other site 153948007742 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 153948007743 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 153948007744 FtsX-like permease family; Region: FtsX; pfam02687 153948007745 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 153948007746 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 153948007747 Walker A/P-loop; other site 153948007748 ATP binding site [chemical binding]; other site 153948007749 Q-loop/lid; other site 153948007750 ABC transporter signature motif; other site 153948007751 Walker B; other site 153948007752 D-loop; other site 153948007753 H-loop/switch region; other site 153948007754 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 153948007755 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 153948007756 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 153948007757 Walker A/P-loop; other site 153948007758 ATP binding site [chemical binding]; other site 153948007759 Q-loop/lid; other site 153948007760 ABC transporter signature motif; other site 153948007761 Walker B; other site 153948007762 D-loop; other site 153948007763 H-loop/switch region; other site 153948007764 Protein of unknown function (DUF1318); Region: DUF1318; cl01547 153948007765 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 153948007766 Dicarboxylate transport; Region: DctA-YdbH; pfam11739 153948007767 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 153948007768 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 153948007769 active site 153948007770 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 153948007771 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 153948007772 catalytic triad [active] 153948007773 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 153948007774 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 153948007775 Smr domain; Region: Smr; pfam01713 153948007776 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 153948007777 thioredoxin reductase; Provisional; Region: PRK10262 153948007778 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 153948007779 Protocatechuate 3,4-dioxygenase (3,4-PCD) catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and beta-subunit and an Fe3+ ion...; Region: 3,4-PCD; cd03459 153948007780 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 153948007781 PEP-CTERM motif; Region: VPEP; pfam07589 153948007782 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 153948007783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 153948007784 active site 153948007785 phosphorylation site [posttranslational modification] 153948007786 intermolecular recognition site; other site 153948007787 dimerization interface [polypeptide binding]; other site 153948007788 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 153948007789 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 153948007790 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; cl02331 153948007791 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 153948007792 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 153948007793 dimerization interface [polypeptide binding]; other site 153948007794 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 153948007795 dimer interface [polypeptide binding]; other site 153948007796 phosphorylation site [posttranslational modification] 153948007797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 153948007798 ATP binding site [chemical binding]; other site 153948007799 Mg2+ binding site [ion binding]; other site 153948007800 G-X-G motif; other site 153948007801 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 153948007802 16S rRNA methyltransferase B; Provisional; Region: PRK10901 153948007803 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 153948007804 putative RNA binding site [nucleotide binding]; other site 153948007805 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 153948007806 S-adenosylmethionine binding site [chemical binding]; other site 153948007807 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 153948007808 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 153948007809 putative active site [active] 153948007810 substrate binding site [chemical binding]; other site 153948007811 putative cosubstrate binding site; other site 153948007812 catalytic site [active] 153948007813 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 153948007814 substrate binding site [chemical binding]; other site 153948007815 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 153948007816 active site 153948007817 catalytic residues [active] 153948007818 metal binding site [ion binding]; metal-binding site 153948007819 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 153948007820 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 153948007821 DNA protecting protein DprA; Region: dprA; TIGR00732 153948007822 Protein of unknown function (DUF494); Region: DUF494; pfam04361 153948007823 DNA topoisomerase III; Validated; Region: PRK08173 153948007824 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 153948007825 active site 153948007826 putative interdomain interaction site [polypeptide binding]; other site 153948007827 putative metal-binding site [ion binding]; other site 153948007828 putative nucleotide binding site [chemical binding]; other site 153948007829 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 153948007830 domain I; other site 153948007831 DNA binding groove [nucleotide binding] 153948007832 phosphate binding site [ion binding]; other site 153948007833 domain II; other site 153948007834 domain III; other site 153948007835 nucleotide binding site [chemical binding]; other site 153948007836 catalytic site [active] 153948007837 domain IV; other site 153948007838 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 153948007839 PADR1 (NUC008) domain; Region: PADR1; pfam08063 153948007840 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 153948007841 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 153948007842 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 153948007843 hinge; other site 153948007844 active site 153948007845 cytidylate kinase; Provisional; Region: cmk; PRK00023 153948007846 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 153948007847 CMP-binding site; other site 153948007848 The sites determining sugar specificity; other site 153948007849 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 153948007850 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 153948007851 RNA binding site [nucleotide binding]; other site 153948007852 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 153948007853 RNA binding site [nucleotide binding]; other site 153948007854 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 153948007855 RNA binding site [nucleotide binding]; other site 153948007856 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 153948007857 RNA binding site [nucleotide binding]; other site 153948007858 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 153948007859 RNA binding site [nucleotide binding]; other site 153948007860 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 153948007861 RNA binding site [nucleotide binding]; other site 153948007862 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 153948007863 IHF dimer interface [polypeptide binding]; other site 153948007864 IHF - DNA interface [nucleotide binding]; other site 153948007865 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 153948007866 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 153948007867 active site 153948007868 dimer interface [polypeptide binding]; other site 153948007869 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 153948007870 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 153948007871 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 153948007872 Walker A/P-loop; other site 153948007873 ATP binding site [chemical binding]; other site 153948007874 Q-loop/lid; other site 153948007875 ABC transporter signature motif; other site 153948007876 Walker B; other site 153948007877 D-loop; other site 153948007878 H-loop/switch region; other site 153948007879 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 153948007880 putative carbohydrate binding site [chemical binding]; other site 153948007881 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 153948007882 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 153948007883 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 153948007884 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 153948007885 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 153948007886 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 153948007887 motif II; other site 153948007888 Transposase domain (DUF772); Region: DUF772; pfam05598 153948007889 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 153948007890 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 153948007891 GTPase RsgA; Reviewed; Region: PRK00098 153948007892 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 153948007893 RNA binding site [nucleotide binding]; other site 153948007894 homodimer interface [polypeptide binding]; other site 153948007895 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 153948007896 GTPase/Zn-binding domain interface [polypeptide binding]; other site 153948007897 GTP/Mg2+ binding site [chemical binding]; other site 153948007898 G4 box; other site 153948007899 G5 box; other site 153948007900 G1 box; other site 153948007901 Switch I region; other site 153948007902 G2 box; other site 153948007903 G3 box; other site 153948007904 Switch II region; other site 153948007905 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 153948007906 aromatic arch; other site 153948007907 DCoH dimer interaction site [polypeptide binding]; other site 153948007908 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 153948007909 DCoH tetramer interaction site [polypeptide binding]; other site 153948007910 substrate binding site [chemical binding]; other site 153948007911 Peptidase family M48; Region: Peptidase_M48; pfam01435 153948007912 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 153948007913 catalytic site [active] 153948007914 putative active site [active] 153948007915 putative substrate binding site [chemical binding]; other site 153948007916 dimer interface [polypeptide binding]; other site 153948007917 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 153948007918 Ca2+ binding site [ion binding]; other site 153948007919 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 153948007920 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 153948007921 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 153948007922 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 153948007923 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 153948007924 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 153948007925 P loop; other site 153948007926 GTP binding site [chemical binding]; other site 153948007927 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 153948007928 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 153948007929 Walker A/P-loop; other site 153948007930 ATP binding site [chemical binding]; other site 153948007931 Q-loop/lid; other site 153948007932 ABC transporter signature motif; other site 153948007933 Walker B; other site 153948007934 D-loop; other site 153948007935 H-loop/switch region; other site 153948007936 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 153948007937 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 153948007938 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 153948007939 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 153948007940 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 153948007941 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 153948007942 DNA binding residues [nucleotide binding] 153948007943 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 153948007944 Helix-turn-helix domain; Region: HTH_38; pfam13936 153948007945 Homeodomain-like domain; Region: HTH_32; pfam13565 153948007946 Integrase core domain; Region: rve; pfam00665 153948007947 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 153948007948 Transposase; Region: HTH_Tnp_1; pfam01527 153948007949 Mor transcription activator family; Region: Mor; cl02360 153948007950 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 153948007951 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 153948007952 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cl14879 153948007953 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 153948007954 Integrase core domain; Region: rve; pfam00665 153948007955 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 153948007956 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 153948007957 Antitoxin ParD; Region: ParD; pfam09386 153948007958 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 153948007959 Helix-turn-helix domain; Region: HTH_38; pfam13936 153948007960 Homeodomain-like domain; Region: HTH_32; pfam13565 153948007961 Integrase core domain; Region: rve; pfam00665 153948007962 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 153948007963 Helix-turn-helix domain; Region: HTH_38; pfam13936 153948007964 Predicted transcriptional regulator [Transcription]; Region: COG3905 153948007965 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 153948007966 transposase/IS protein; Provisional; Region: PRK09183 153948007967 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 153948007968 ATP binding site [chemical binding]; other site 153948007969 Walker B motif; other site 153948007970 arginine finger; other site 153948007971 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 153948007972 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 153948007973 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 153948007974 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 153948007975 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 153948007976 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 153948007977 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 153948007978 transposase/IS protein; Provisional; Region: PRK09183 153948007979 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 153948007980 ATP binding site [chemical binding]; other site 153948007981 Walker B motif; other site 153948007982 arginine finger; other site 153948007983 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 153948007984 Predicted transcriptional regulator [Transcription]; Region: COG3905 153948007985 Transcriptional activator TraM; Region: Activator-TraM; cl11943 153948007986 integrase; Provisional; Region: int; PHA02601 153948007987 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 153948007988 Int/Topo IB signature motif; other site 153948007989 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 153948007990 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 153948007991 active site 153948007992 DNA binding site [nucleotide binding] 153948007993 Int/Topo IB signature motif; other site 153948007994 Helix-turn-helix domain; Region: HTH_17; cl17695 153948007995 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 153948007996 Aspartyl protease; Region: Asp_protease_2; pfam13650 153948007997 inhibitor binding site; inhibition site 153948007998 catalytic motif [active] 153948007999 Catalytic residue [active] 153948008000 Active site flap [active] 153948008001 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 153948008002 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 153948008003 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 153948008004 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 153948008005 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 153948008006 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 153948008007 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 153948008008 DNA binding residues [nucleotide binding] 153948008009 DNA primase; Validated; Region: dnaG; PRK05667 153948008010 CHC2 zinc finger; Region: zf-CHC2; pfam01807 153948008011 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 153948008012 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 153948008013 active site 153948008014 metal binding site [ion binding]; metal-binding site 153948008015 interdomain interaction site; other site 153948008016 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 153948008017 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 153948008018 Yqey-like protein; Region: YqeY; pfam09424 153948008019 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 153948008020 hypothetical protein; Provisional; Region: PRK05255 153948008021 peptidase PmbA; Provisional; Region: PRK11040 153948008022 PEP-CTERM motif; Region: VPEP; pfam07589 153948008023 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 153948008024 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 153948008025 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 153948008026 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 153948008027 putative active site [active] 153948008028 Zn binding site [ion binding]; other site 153948008029 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 153948008030 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 153948008031 heme binding site [chemical binding]; other site 153948008032 ferroxidase pore; other site 153948008033 ferroxidase diiron center [ion binding]; other site 153948008034 Fic family protein [Function unknown]; Region: COG3177 153948008035 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 153948008036 Fic/DOC family; Region: Fic; pfam02661 153948008037 Protein of unknown function DUF45; Region: DUF45; pfam01863 153948008038 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 153948008039 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 153948008040 putative acyl-acceptor binding pocket; other site 153948008041 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 153948008042 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 153948008043 active site 153948008044 motif I; other site 153948008045 motif II; other site 153948008046 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 153948008047 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 153948008048 dimer interface [polypeptide binding]; other site 153948008049 motif 1; other site 153948008050 active site 153948008051 motif 2; other site 153948008052 motif 3; other site 153948008053 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 153948008054 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 153948008055 putative active site [active] 153948008056 catalytic triad [active] 153948008057 putative dimer interface [polypeptide binding]; other site 153948008058 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 153948008059 binding surface 153948008060 TPR motif; other site 153948008061 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 153948008062 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 153948008063 binding surface 153948008064 TPR motif; other site 153948008065 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 153948008066 binding surface 153948008067 TPR motif; other site 153948008068 TPR repeat; Region: TPR_11; pfam13414 153948008069 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 153948008070 binding surface 153948008071 TPR motif; other site 153948008072 septum formation inhibitor; Reviewed; Region: minC; PRK00339 153948008073 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 153948008074 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 153948008075 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 153948008076 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 153948008077 Switch I; other site 153948008078 Switch II; other site 153948008079 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 153948008080 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 153948008081 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 153948008082 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 153948008083 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 153948008084 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 153948008085 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 153948008086 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 153948008087 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 153948008088 active site 153948008089 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 153948008090 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 153948008091 5S rRNA interface [nucleotide binding]; other site 153948008092 CTC domain interface [polypeptide binding]; other site 153948008093 L16 interface [polypeptide binding]; other site 153948008094 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 153948008095 putative active site [active] 153948008096 catalytic residue [active] 153948008097 GTP-binding protein YchF; Reviewed; Region: PRK09601 153948008098 YchF GTPase; Region: YchF; cd01900 153948008099 G1 box; other site 153948008100 GTP/Mg2+ binding site [chemical binding]; other site 153948008101 Switch I region; other site 153948008102 G2 box; other site 153948008103 Switch II region; other site 153948008104 G3 box; other site 153948008105 G4 box; other site 153948008106 G5 box; other site 153948008107 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 153948008108 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 153948008109 Fic family protein [Function unknown]; Region: COG3177 153948008110 Fic/DOC family; Region: Fic; pfam02661 153948008111 Protein of unknown function DUF262; Region: DUF262; pfam03235 153948008112 ATP-dependent helicase HepA; Validated; Region: PRK04914 153948008113 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 153948008114 ATP binding site [chemical binding]; other site 153948008115 putative Mg++ binding site [ion binding]; other site 153948008116 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 153948008117 nucleotide binding region [chemical binding]; other site 153948008118 ATP-binding site [chemical binding]; other site 153948008119 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 153948008120 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 153948008121 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 153948008122 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 153948008123 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 153948008124 HemN C-terminal domain; Region: HemN_C; pfam06969 153948008125 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 153948008126 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 153948008127 ligand binding site [chemical binding]; other site 153948008128 flexible hinge region; other site 153948008129 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 153948008130 non-specific DNA interactions [nucleotide binding]; other site 153948008131 DNA binding site [nucleotide binding] 153948008132 sequence specific DNA binding site [nucleotide binding]; other site 153948008133 putative cAMP binding site [chemical binding]; other site 153948008134 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 153948008135 rRNA interaction site [nucleotide binding]; other site 153948008136 S8 interaction site; other site 153948008137 putative laminin-1 binding site; other site 153948008138 elongation factor Ts; Provisional; Region: tsf; PRK09377 153948008139 UBA/TS-N domain; Region: UBA; pfam00627 153948008140 Elongation factor TS; Region: EF_TS; pfam00889 153948008141 Elongation factor TS; Region: EF_TS; pfam00889 153948008142 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 153948008143 putative nucleotide binding site [chemical binding]; other site 153948008144 uridine monophosphate binding site [chemical binding]; other site 153948008145 homohexameric interface [polypeptide binding]; other site 153948008146 ribosome recycling factor; Reviewed; Region: frr; PRK00083 153948008147 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 153948008148 hinge region; other site 153948008149 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 153948008150 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 153948008151 catalytic residue [active] 153948008152 putative FPP diphosphate binding site; other site 153948008153 putative FPP binding hydrophobic cleft; other site 153948008154 dimer interface [polypeptide binding]; other site 153948008155 putative IPP diphosphate binding site; other site 153948008156 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 153948008157 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 153948008158 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 153948008159 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 153948008160 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 153948008161 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 153948008162 zinc metallopeptidase RseP; Provisional; Region: PRK10779 153948008163 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 153948008164 active site 153948008165 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 153948008166 protein binding site [polypeptide binding]; other site 153948008167 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 153948008168 protein binding site [polypeptide binding]; other site 153948008169 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 153948008170 putative substrate binding region [chemical binding]; other site 153948008171 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 153948008172 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 153948008173 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 153948008174 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 153948008175 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 153948008176 Surface antigen; Region: Bac_surface_Ag; pfam01103 153948008177 periplasmic chaperone; Provisional; Region: PRK10780 153948008178 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 153948008179 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 153948008180 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 153948008181 RNA/DNA hybrid binding site [nucleotide binding]; other site 153948008182 active site 153948008183 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 153948008184 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 153948008185 MutS domain I; Region: MutS_I; pfam01624 153948008186 MutS domain II; Region: MutS_II; pfam05188 153948008187 MutS domain III; Region: MutS_III; pfam05192 153948008188 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 153948008189 Walker A/P-loop; other site 153948008190 ATP binding site [chemical binding]; other site 153948008191 Q-loop/lid; other site 153948008192 ABC transporter signature motif; other site 153948008193 Walker B; other site 153948008194 D-loop; other site 153948008195 H-loop/switch region; other site 153948008196 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 153948008197 FOG: CBS domain [General function prediction only]; Region: COG0517 153948008198 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 153948008199 Transposase domain (DUF772); Region: DUF772; pfam05598 153948008200 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 153948008201 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 153948008202 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 153948008203 metal binding site 2 [ion binding]; metal-binding site 153948008204 putative DNA binding helix; other site 153948008205 metal binding site 1 [ion binding]; metal-binding site 153948008206 dimer interface [polypeptide binding]; other site 153948008207 structural Zn2+ binding site [ion binding]; other site 153948008208 TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779 153948008209 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 153948008210 short chain dehydrogenase; Provisional; Region: PRK05993 153948008211 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 153948008212 NADP binding site [chemical binding]; other site 153948008213 active site 153948008214 steroid binding site; other site 153948008215 Protein of unknown function (DUF3460); Region: DUF3460; pfam11943 153948008216 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 153948008217 Uncharacterized conserved protein [Function unknown]; Region: COG2835 153948008218 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 153948008219 ParB-like nuclease domain; Region: ParBc; pfam02195 153948008220 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 153948008221 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 153948008222 P-loop; other site 153948008223 Magnesium ion binding site [ion binding]; other site 153948008224 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 153948008225 Magnesium ion binding site [ion binding]; other site 153948008226 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 153948008227 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 153948008228 S-adenosylmethionine binding site [chemical binding]; other site 153948008229 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 153948008230 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 153948008231 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 153948008232 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 153948008233 Helix-turn-helix domain; Region: HTH_38; pfam13936 153948008234 Integrase core domain; Region: rve; pfam00665 153948008235 transposase/IS protein; Provisional; Region: PRK09183 153948008236 Putative ATP-dependent Lon protease; Region: Lon_2; cl11979 153948008237 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 153948008238 Walker A motif; other site 153948008239 ATP binding site [chemical binding]; other site 153948008240 Walker B motif; other site 153948008241 arginine finger; other site 153948008242 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 153948008243 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 153948008244 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 153948008245 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 153948008246 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 153948008247 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 153948008248 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 153948008249 Fic/DOC family; Region: Fic; cl00960 153948008250 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 153948008251 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 153948008252 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 153948008253 ATP binding site [chemical binding]; other site 153948008254 putative Mg++ binding site [ion binding]; other site 153948008255 Transposase IS200 like; Region: Y1_Tnp; cl00848 153948008256 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 153948008257 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 153948008258 Predicted flavoprotein [General function prediction only]; Region: COG0431 153948008259 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 153948008260 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 153948008261 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 153948008262 HlyD family secretion protein; Region: HlyD_3; pfam13437 153948008263 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 153948008264 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 153948008265 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 153948008266 DEAD-like helicases superfamily; Region: DEXDc; smart00487 153948008267 ATP binding site [chemical binding]; other site 153948008268 Mg++ binding site [ion binding]; other site 153948008269 motif III; other site 153948008270 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 153948008271 nucleotide binding region [chemical binding]; other site 153948008272 ATP-binding site [chemical binding]; other site 153948008273 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 153948008274 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 153948008275 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 153948008276 homodimer interface [polypeptide binding]; other site 153948008277 chemical substrate binding site [chemical binding]; other site 153948008278 oligomer interface [polypeptide binding]; other site 153948008279 metal binding site [ion binding]; metal-binding site 153948008280 Glyoxal oxidase N-terminus; Region: Glyoxal_oxid_N; pfam07250 153948008281 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 153948008282 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 153948008283 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 153948008284 hypothetical protein; Provisional; Region: PRK01184 153948008285 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 153948008286 active site 153948008287 Zn binding site [ion binding]; other site 153948008288 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 153948008289 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 153948008290 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 153948008291 ABC transporter; Region: ABC_tran_2; pfam12848 153948008292 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 153948008293 Protein of unknown function (DUF2835); Region: DUF2835; pfam11197 153948008294 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 153948008295 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 153948008296 RNA binding surface [nucleotide binding]; other site 153948008297 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 153948008298 active site 153948008299 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 153948008300 active site residue [active] 153948008301 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 153948008302 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 153948008303 ThiC-associated domain; Region: ThiC-associated; pfam13667 153948008304 ThiC family; Region: ThiC; pfam01964 153948008305 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 153948008306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 153948008307 S-adenosylmethionine binding site [chemical binding]; other site 153948008308 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 153948008309 hypothetical protein; Provisional; Region: PRK11281 153948008310 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 153948008311 Mechanosensitive ion channel; Region: MS_channel; pfam00924 153948008312 poly(A) polymerase; Region: pcnB; TIGR01942 153948008313 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 153948008314 active site 153948008315 NTP binding site [chemical binding]; other site 153948008316 metal binding triad [ion binding]; metal-binding site 153948008317 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 153948008318 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 153948008319 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 153948008320 catalytic center binding site [active] 153948008321 ATP binding site [chemical binding]; other site 153948008322 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 153948008323 oligomerization interface [polypeptide binding]; other site 153948008324 active site 153948008325 metal binding site [ion binding]; metal-binding site 153948008326 pantoate--beta-alanine ligase; Region: panC; TIGR00018 153948008327 Pantoate-beta-alanine ligase; Region: PanC; cd00560 153948008328 active site 153948008329 ATP-binding site [chemical binding]; other site 153948008330 pantoate-binding site; other site 153948008331 HXXH motif; other site 153948008332 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 153948008333 HlyD family secretion protein; Region: HlyD_3; pfam13437 153948008334 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 153948008335 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 153948008336 Mg++ binding site [ion binding]; other site 153948008337 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 153948008338 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 153948008339 Sodium Bile acid symporter family; Region: SBF; cl17470 153948008340 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 153948008341 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 153948008342 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 153948008343 hypothetical protein; Provisional; Region: PRK09272 153948008344 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 153948008345 active site clefts [active] 153948008346 zinc binding site [ion binding]; other site 153948008347 dimer interface [polypeptide binding]; other site 153948008348 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 153948008349 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 153948008350 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 153948008351 HlyD family secretion protein; Region: HlyD_3; pfam13437 153948008352 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 153948008353 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 153948008354 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 153948008355 catalytic residues [active] 153948008356 Domain of unknown function (DUF4266); Region: DUF4266; pfam14086 153948008357 Protein of unknown function (DUF3570); Region: DUF3570; pfam12094 153948008358 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 153948008359 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 153948008360 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 153948008361 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 153948008362 N-acetyl-D-glucosamine binding site [chemical binding]; other site 153948008363 catalytic residue [active] 153948008364 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 153948008365 conjugal transfer protein TrbJ; Provisional; Region: PRK13879 153948008366 conjugal transfer protein TrbI; Provisional; Region: PRK13881 153948008367 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 153948008368 conjugal transfer protein TrbH; Provisional; Region: PRK13883 153948008369 Conjugal transfer protein TrbH; Region: TrbH; pfam07283 153948008370 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 153948008371 VirB7 interaction site; other site 153948008372 VirB8 protein; Region: VirB8; cl01500 153948008373 conjugal transfer protein TrbE; Provisional; Region: PRK13891 153948008374 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 153948008375 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 153948008376 Walker A/P-loop; other site 153948008377 ATP binding site [chemical binding]; other site 153948008378 conjugal transfer protein TrbD; Provisional; Region: PRK13823 153948008379 TrbC/VIRB2 family; Region: TrbC; cl01583 153948008380 conjugal transfer ATPase TrbB; Provisional; Region: PRK13894 153948008381 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 153948008382 ATP binding site [chemical binding]; other site 153948008383 Walker A motif; other site 153948008384 hexamer interface [polypeptide binding]; other site 153948008385 Walker B motif; other site 153948008386 conjugal transfer protein TrbA; Provisional; Region: PRK13890 153948008387 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 153948008388 sequence-specific DNA binding site [nucleotide binding]; other site 153948008389 salt bridge; other site 153948008390 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 153948008391 ParB-like nuclease domain; Region: ParB; smart00470 153948008392 KorB domain; Region: KorB; pfam08535 153948008393 Uncharacterized conserved protein [Function unknown]; Region: COG3391 153948008394 Transcriptional regulator [Transcription]; Region: LysR; COG0583 153948008395 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 153948008396 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 153948008397 dimerization interface [polypeptide binding]; other site 153948008398 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 153948008399 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 153948008400 P-loop; other site 153948008401 Magnesium ion binding site [ion binding]; other site 153948008402 Transcriptional activator TraM; Region: Activator-TraM; cl11943 153948008403 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 153948008404 P-loop; other site 153948008405 conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877 153948008406 conjugal transfer relaxase TraI; Provisional; Region: PRK13878 153948008407 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 153948008408 conjugal transfer coupling protein TraG; Provisional; Region: PRK13880 153948008409 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 153948008410 Walker A motif; other site 153948008411 ATP binding site [chemical binding]; other site 153948008412 Walker B motif; other site 153948008413 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 153948008414 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 153948008415 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 153948008416 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 153948008417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 153948008418 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 153948008419 active site 153948008420 metal binding site [ion binding]; metal-binding site 153948008421 interdomain interaction site; other site 153948008422 Protein of unknown function (DUF1044); Region: DUF1044; pfam06296 153948008423 Predicted transcriptional regulator [Transcription]; Region: COG2944 153948008424 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 153948008425 non-specific DNA binding site [nucleotide binding]; other site 153948008426 salt bridge; other site 153948008427 sequence-specific DNA binding site [nucleotide binding]; other site 153948008428 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 153948008429 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 153948008430 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 153948008431 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 153948008432 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 153948008433 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 153948008434 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 153948008435 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 153948008436 ATP binding site [chemical binding]; other site 153948008437 putative Mg++ binding site [ion binding]; other site 153948008438 helicase superfamily c-terminal domain; Region: HELICc; smart00490 153948008439 nucleotide binding region [chemical binding]; other site 153948008440 ATP-binding site [chemical binding]; other site 153948008441 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 153948008442 IHF dimer interface [polypeptide binding]; other site 153948008443 IHF - DNA interface [nucleotide binding]; other site 153948008444 Uncharacterized conserved protein [Function unknown]; Region: COG1479 153948008445 Protein of unknown function DUF262; Region: DUF262; pfam03235 153948008446 Uncharacterized conserved protein [Function unknown]; Region: COG4938 153948008447 T5orf172 domain; Region: T5orf172; pfam10544 153948008448 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 153948008449 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 153948008450 Pseudomurein-binding repeat; Region: PMBR; pfam09373 153948008451 Methyltransferase domain; Region: Methyltransf_26; pfam13659 153948008452 Domain of unknown function (DUF1917); Region: DUF1917; pfam08939 153948008453 PemK-like protein; Region: PemK; pfam02452 153948008454 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 153948008455 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 153948008456 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 153948008457 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 153948008458 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 153948008459 active site 153948008460 DNA binding site [nucleotide binding] 153948008461 Int/Topo IB signature motif; other site 153948008462 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 153948008463 arsenical pump membrane protein; Provisional; Region: PRK15445 153948008464 transmembrane helices; other site 153948008465 Low molecular weight phosphatase family; Region: LMWPc; cd00115 153948008466 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 153948008467 active site 153948008468 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 153948008469 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 153948008470 putative metal binding site [ion binding]; other site 153948008471 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 153948008472 dimerization interface [polypeptide binding]; other site 153948008473 putative DNA binding site [nucleotide binding]; other site 153948008474 putative Zn2+ binding site [ion binding]; other site 153948008475 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 153948008476 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 153948008477 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 153948008478 Methyltransferase domain; Region: Methyltransf_31; pfam13847 153948008479 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 153948008480 S-adenosylmethionine binding site [chemical binding]; other site