-- dump date   	20140619_164619
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
261292000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
261292000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
261292000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
261292000004	Walker A motif; other site
261292000005	ATP binding site [chemical binding]; other site
261292000006	Walker B motif; other site
261292000007	arginine finger; other site
261292000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
261292000009	DnaA box-binding interface [nucleotide binding]; other site
261292000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
261292000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
261292000012	putative DNA binding surface [nucleotide binding]; other site
261292000013	dimer interface [polypeptide binding]; other site
261292000014	beta-clamp/clamp loader binding surface; other site
261292000015	beta-clamp/translesion DNA polymerase binding surface; other site
261292000016	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
261292000017	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292000018	Mg2+ binding site [ion binding]; other site
261292000019	G-X-G motif; other site
261292000020	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
261292000021	anchoring element; other site
261292000022	dimer interface [polypeptide binding]; other site
261292000023	ATP binding site [chemical binding]; other site
261292000024	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
261292000025	active site
261292000026	putative metal-binding site [ion binding]; other site
261292000027	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
261292000028	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
261292000029	ATP binding site [chemical binding]; other site
261292000030	putative Mg++ binding site [ion binding]; other site
261292000031	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
261292000032	nucleotide binding region [chemical binding]; other site
261292000033	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
261292000034	ATP-binding site [chemical binding]; other site
261292000035	AIPR protein; Region: AIPR; pfam10592
261292000036	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
261292000037	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
261292000038	DNA methylase; Region: N6_N4_Mtase; pfam01555
261292000039	DNA methylase; Region: N6_N4_Mtase; pfam01555
261292000040	Virulence protein [General function prediction only]; Region: COG3943
261292000041	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
261292000042	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
261292000043	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
261292000044	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
261292000045	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
261292000046	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
261292000047	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
261292000048	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
261292000049	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
261292000050	G1 box; other site
261292000051	putative GEF interaction site [polypeptide binding]; other site
261292000052	GTP/Mg2+ binding site [chemical binding]; other site
261292000053	Switch I region; other site
261292000054	G2 box; other site
261292000055	G3 box; other site
261292000056	Switch II region; other site
261292000057	G4 box; other site
261292000058	G5 box; other site
261292000059	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
261292000060	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
261292000061	Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839
261292000062	Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839
261292000063	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
261292000064	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
261292000065	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
261292000066	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
261292000067	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
261292000068	DsbD alpha interface [polypeptide binding]; other site
261292000069	catalytic residues [active]
261292000070	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
261292000071	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
261292000072	catalytic residues [active]
261292000073	BON domain; Region: BON; pfam04972
261292000074	Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861
261292000075	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
261292000076	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
261292000077	Ligand Binding Site [chemical binding]; other site
261292000078	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
261292000079	Predicted metal-binding protein [General function prediction only]; Region: COG3019
261292000080	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
261292000081	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
261292000082	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
261292000083	BON domain; Region: BON; pfam04972
261292000084	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
261292000085	Putative glucoamylase; Region: Glycoamylase; pfam10091
261292000086	Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753
261292000087	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
261292000088	First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756
261292000089	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
261292000090	putative active site [active]
261292000091	transaldolase; Provisional; Region: PRK03903
261292000092	catalytic residue [active]
261292000093	Domain of unknown function (DUF1840); Region: DUF1840; pfam08895
261292000094	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
261292000095	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
261292000096	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
261292000097	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
261292000098	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
261292000099	Domain of unknown function (DUF1840); Region: DUF1840; pfam08895
261292000100	phosphoglucomutase; Validated; Region: PRK07564
261292000101	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
261292000102	active site
261292000103	substrate binding site [chemical binding]; other site
261292000104	metal binding site [ion binding]; metal-binding site
261292000105	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
261292000106	putative homodimer interface [polypeptide binding]; other site
261292000107	putative active site pocket [active]
261292000108	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
261292000109	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
261292000110	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
261292000111	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
261292000112	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
261292000113	Soluble P-type ATPase [General function prediction only]; Region: COG4087
261292000114	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
261292000115	Acetate kinase [Energy production and conversion]; Region: ackA; COG0282
261292000116	propionate/acetate kinase; Provisional; Region: PRK12379
261292000117	putative phosphoketolase; Provisional; Region: PRK05261
261292000118	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
261292000119	TPP-binding site; other site
261292000120	XFP C-terminal domain; Region: XFP_C; pfam09363
261292000121	Predicted membrane protein [Function unknown]; Region: COG4325
261292000122	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
261292000123	alternate F1F0 ATPase, F1 subunit beta; Region: alt_F1F0_F1_bet; TIGR03305
261292000124	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
261292000125	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
261292000126	alpha subunit interaction interface [polypeptide binding]; other site
261292000127	Walker A motif; other site
261292000128	ATP binding site [chemical binding]; other site
261292000129	Walker B motif; other site
261292000130	inhibitor binding site; inhibition site
261292000131	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
261292000132	F0F1 ATP synthase subunit epsilon; Validated; Region: PRK06228
261292000133	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
261292000134	gamma subunit interface [polypeptide binding]; other site
261292000135	epsilon subunit interface [polypeptide binding]; other site
261292000136	LBP interface [polypeptide binding]; other site
261292000137	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
261292000138	F1/F0 ATPase, Methanosarcina type, subunit 2; Region: F1F0_chp_2; TIGR03165
261292000139	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
261292000140	alternate F1F0 ATPase, F0 subunit A; Region: altF1_A; TIGR03306
261292000141	alternate F1F0 ATPase, F0 subunit C; Region: alt_F1F0_F0_C; TIGR03322
261292000142	alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321
261292000143	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
261292000144	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
261292000145	alternate F1F0 ATPase, F1 subunit alpha; Region: alt_F1F0_F1_al; TIGR03324
261292000146	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
261292000147	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
261292000148	beta subunit interaction interface [polypeptide binding]; other site
261292000149	Walker A motif; other site
261292000150	ATP binding site [chemical binding]; other site
261292000151	Walker B motif; other site
261292000152	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
261292000153	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
261292000154	core domain interface [polypeptide binding]; other site
261292000155	delta subunit interface [polypeptide binding]; other site
261292000156	epsilon subunit interface [polypeptide binding]; other site
261292000157	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
261292000158	active site
261292000159	tetramer interface; other site
261292000160	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
261292000161	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
261292000162	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
261292000163	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
261292000164	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
261292000165	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
261292000166	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
261292000167	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
261292000168	Transposase; Region: HTH_Tnp_1; cl17663
261292000169	PEP-CTERM motif; Region: VPEP; pfam07589
261292000170	Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152
261292000171	putative heme binding pocket [chemical binding]; other site
261292000172	Protein of unknown function (DUF1207); Region: DUF1207; pfam06727
261292000173	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
261292000174	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292000175	active site
261292000176	phosphorylation site [posttranslational modification]
261292000177	intermolecular recognition site; other site
261292000178	dimerization interface [polypeptide binding]; other site
261292000179	PAS fold; Region: PAS; pfam00989
261292000180	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292000181	putative active site [active]
261292000182	heme pocket [chemical binding]; other site
261292000183	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
261292000184	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
261292000185	metal binding site [ion binding]; metal-binding site
261292000186	active site
261292000187	I-site; other site
261292000188	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
261292000189	Protein of unknown function (DUF692); Region: DUF692; cl01263
261292000190	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262
261292000191	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
261292000192	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
261292000193	ligand binding site [chemical binding]; other site
261292000194	Domain of unknown function (DUF4398); Region: DUF4398; pfam14346
261292000195	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
261292000196	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
261292000197	ligand binding site [chemical binding]; other site
261292000198	flexible hinge region; other site
261292000199	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
261292000200	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
261292000201	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
261292000202	ligand binding site [chemical binding]; other site
261292000203	flexible hinge region; other site
261292000204	non-specific DNA interactions [nucleotide binding]; other site
261292000205	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
261292000206	DNA binding site [nucleotide binding]
261292000207	sequence specific DNA binding site [nucleotide binding]; other site
261292000208	putative cAMP binding site [chemical binding]; other site
261292000209	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
261292000210	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
261292000211	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
261292000212	2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745
261292000213	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
261292000214	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
261292000215	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
261292000216	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
261292000217	putative NADP binding site [chemical binding]; other site
261292000218	putative substrate binding site [chemical binding]; other site
261292000219	active site
261292000220	arginine decarboxylase; Provisional; Region: PRK05354
261292000221	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
261292000222	dimer interface [polypeptide binding]; other site
261292000223	active site
261292000224	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
261292000225	catalytic residues [active]
261292000226	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
261292000227	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
261292000228	oligomer interface [polypeptide binding]; other site
261292000229	putative active site [active]
261292000230	Mn binding site [ion binding]; other site
261292000231	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
261292000232	PRC-barrel domain; Region: PRC; pfam05239
261292000233	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
261292000234	Protein of unknown function (DUF3309); Region: DUF3309; pfam11752
261292000235	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
261292000236	Fatty acid desaturase; Region: FA_desaturase; pfam00487
261292000237	Di-iron ligands [ion binding]; other site
261292000238	Transposase; Region: DDE_Tnp_ISL3; pfam01610
261292000239	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
261292000240	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
261292000241	ligand binding site [chemical binding]; other site
261292000242	flexible hinge region; other site
261292000243	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
261292000244	non-specific DNA interactions [nucleotide binding]; other site
261292000245	DNA binding site [nucleotide binding]
261292000246	sequence specific DNA binding site [nucleotide binding]; other site
261292000247	putative cAMP binding site [chemical binding]; other site
261292000248	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
261292000249	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
261292000250	Walker A/P-loop; other site
261292000251	ATP binding site [chemical binding]; other site
261292000252	Q-loop/lid; other site
261292000253	ABC transporter signature motif; other site
261292000254	Walker B; other site
261292000255	D-loop; other site
261292000256	H-loop/switch region; other site
261292000257	DevC protein; Region: devC; TIGR01185
261292000258	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
261292000259	FtsX-like permease family; Region: FtsX; pfam02687
261292000260	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
261292000261	HlyD family secretion protein; Region: HlyD_3; pfam13437
261292000262	AAA ATPase domain; Region: AAA_16; pfam13191
261292000263	NACHT domain; Region: NACHT; pfam05729
261292000264	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
261292000265	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
261292000266	homodimer interface [polypeptide binding]; other site
261292000267	chemical substrate binding site [chemical binding]; other site
261292000268	oligomer interface [polypeptide binding]; other site
261292000269	metal binding site [ion binding]; metal-binding site
261292000270	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
261292000271	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
261292000272	S-adenosylmethionine binding site [chemical binding]; other site
261292000273	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
261292000274	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
261292000275	ATP binding site [chemical binding]; other site
261292000276	Mg++ binding site [ion binding]; other site
261292000277	motif III; other site
261292000278	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
261292000279	nucleotide binding region [chemical binding]; other site
261292000280	ATP-binding site [chemical binding]; other site
261292000281	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
261292000282	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
261292000283	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
261292000284	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
261292000285	HlyD family secretion protein; Region: HlyD_3; pfam13437
261292000286	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
261292000287	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
261292000288	GAF domain; Region: GAF; pfam01590
261292000289	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
261292000290	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
261292000291	metal binding site [ion binding]; metal-binding site
261292000292	active site
261292000293	I-site; other site
261292000294	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
261292000295	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
261292000296	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
261292000297	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
261292000298	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
261292000299	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
261292000300	S-adenosylmethionine binding site [chemical binding]; other site
261292000301	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
261292000302	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
261292000303	P-loop; other site
261292000304	Magnesium ion binding site [ion binding]; other site
261292000305	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
261292000306	Magnesium ion binding site [ion binding]; other site
261292000307	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
261292000308	ParB-like nuclease domain; Region: ParBc; pfam02195
261292000309	Uncharacterized conserved protein [Function unknown]; Region: COG2835
261292000310	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
261292000311	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
261292000312	malate--CoA ligase subunit beta; Provisional; Region: PRK14046
261292000313	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
261292000314	CoA-ligase; Region: Ligase_CoA; pfam00549
261292000315	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
261292000316	CoA binding domain; Region: CoA_binding; smart00881
261292000317	CoA-ligase; Region: Ligase_CoA; pfam00549
261292000318	hypothetical protein; Provisional; Region: PRK05208
261292000319	Competence-damaged protein; Region: CinA; pfam02464
261292000320	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
261292000321	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
261292000322	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
261292000323	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
261292000324	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
261292000325	HsdM N-terminal domain; Region: HsdM_N; pfam12161
261292000326	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
261292000327	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
261292000328	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
261292000329	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
261292000330	oligomeric interface; other site
261292000331	putative active site [active]
261292000332	homodimer interface [polypeptide binding]; other site
261292000333	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
261292000334	Fic family protein [Function unknown]; Region: COG3177
261292000335	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
261292000336	Fic/DOC family; Region: Fic; pfam02661
261292000337	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
261292000338	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
261292000339	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
261292000340	ATP binding site [chemical binding]; other site
261292000341	putative Mg++ binding site [ion binding]; other site
261292000342	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
261292000343	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
261292000344	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
261292000345	Walker A motif; other site
261292000346	ATP binding site [chemical binding]; other site
261292000347	Walker B motif; other site
261292000348	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
261292000349	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
261292000350	Walker A motif; other site
261292000351	ATP binding site [chemical binding]; other site
261292000352	Walker B motif; other site
261292000353	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
261292000354	EAL domain; Region: EAL; pfam00563
261292000355	HDOD domain; Region: HDOD; pfam08668
261292000356	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
261292000357	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
261292000358	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
261292000359	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
261292000360	active site
261292000361	(T/H)XGH motif; other site
261292000362	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
261292000363	S-adenosylmethionine binding site [chemical binding]; other site
261292000364	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
261292000365	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
261292000366	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
261292000367	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
261292000368	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
261292000369	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
261292000370	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
261292000371	domain interfaces; other site
261292000372	active site
261292000373	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
261292000374	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
261292000375	active site
261292000376	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
261292000377	HemY protein N-terminus; Region: HemY_N; pfam07219
261292000378	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
261292000379	binding surface
261292000380	TPR motif; other site
261292000381	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
261292000382	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
261292000383	catalytic loop [active]
261292000384	iron binding site [ion binding]; other site
261292000385	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
261292000386	FAD binding pocket [chemical binding]; other site
261292000387	FAD binding motif [chemical binding]; other site
261292000388	phosphate binding motif [ion binding]; other site
261292000389	beta-alpha-beta structure motif; other site
261292000390	NAD binding pocket [chemical binding]; other site
261292000391	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
261292000392	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
261292000393	putative NAD(P) binding site [chemical binding]; other site
261292000394	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
261292000395	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
261292000396	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
261292000397	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
261292000398	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
261292000399	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
261292000400	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
261292000401	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
261292000402	CoA-binding site [chemical binding]; other site
261292000403	ATP-binding [chemical binding]; other site
261292000404	hypothetical protein; Provisional; Region: PRK05287
261292000405	cyanophycin synthetase; Provisional; Region: PRK14016
261292000406	ATP-grasp domain; Region: ATP-grasp_4; cl17255
261292000407	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
261292000408	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
261292000409	cyanophycin synthetase; Provisional; Region: PRK14016
261292000410	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
261292000411	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
261292000412	Homeodomain-like domain; Region: HTH_23; pfam13384
261292000413	Winged helix-turn helix; Region: HTH_29; pfam13551
261292000414	Homeodomain-like domain; Region: HTH_32; pfam13565
261292000415	DDE superfamily endonuclease; Region: DDE_3; pfam13358
261292000416	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
261292000417	Domain of unknown function DUF21; Region: DUF21; pfam01595
261292000418	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
261292000419	Transporter associated domain; Region: CorC_HlyC; smart01091
261292000420	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
261292000421	Lumazine binding domain; Region: Lum_binding; pfam00677
261292000422	Lumazine binding domain; Region: Lum_binding; pfam00677
261292000423	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
261292000424	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
261292000425	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
261292000426	dimerization interface [polypeptide binding]; other site
261292000427	active site
261292000428	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
261292000429	homopentamer interface [polypeptide binding]; other site
261292000430	active site
261292000431	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
261292000432	putative RNA binding site [nucleotide binding]; other site
261292000433	thiamine monophosphate kinase; Provisional; Region: PRK05731
261292000434	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
261292000435	ATP binding site [chemical binding]; other site
261292000436	dimerization interface [polypeptide binding]; other site
261292000437	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
261292000438	tetramer interfaces [polypeptide binding]; other site
261292000439	binuclear metal-binding site [ion binding]; other site
261292000440	Protein of unknown function (DUF466); Region: DUF466; pfam04328
261292000441	carbon starvation protein A; Provisional; Region: PRK15015
261292000442	Carbon starvation protein CstA; Region: CstA; pfam02554
261292000443	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
261292000444	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
261292000445	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
261292000446	transmembrane helices; other site
261292000447	PAS fold; Region: PAS_4; pfam08448
261292000448	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
261292000449	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255
261292000450	isocitrate dehydrogenase; Validated; Region: PRK07362
261292000451	isocitrate dehydrogenase; Reviewed; Region: PRK07006
261292000452	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
261292000453	DNA-binding site [nucleotide binding]; DNA binding site
261292000454	RNA-binding motif; other site
261292000455	Uncharacterized conserved protein [Function unknown]; Region: COG2127
261292000456	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
261292000457	Clp amino terminal domain; Region: Clp_N; pfam02861
261292000458	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
261292000459	Walker A motif; other site
261292000460	ATP binding site [chemical binding]; other site
261292000461	Walker B motif; other site
261292000462	arginine finger; other site
261292000463	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
261292000464	Walker A motif; other site
261292000465	ATP binding site [chemical binding]; other site
261292000466	Walker B motif; other site
261292000467	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
261292000468	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
261292000469	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
261292000470	Integrase core domain; Region: rve; pfam00665
261292000471	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
261292000472	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
261292000473	Transposase domain (DUF772); Region: DUF772; pfam05598
261292000474	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
261292000475	DDE superfamily endonuclease; Region: DDE_4; cl17710
261292000476	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
261292000477	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
261292000478	dimer interface [polypeptide binding]; other site
261292000479	active site
261292000480	glycine-pyridoxal phosphate binding site [chemical binding]; other site
261292000481	folate binding site [chemical binding]; other site
261292000482	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
261292000483	ATP cone domain; Region: ATP-cone; pfam03477
261292000484	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
261292000485	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
261292000486	catalytic motif [active]
261292000487	Zn binding site [ion binding]; other site
261292000488	RibD C-terminal domain; Region: RibD_C; cl17279
261292000489	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
261292000490	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292000491	active site
261292000492	phosphorylation site [posttranslational modification]
261292000493	intermolecular recognition site; other site
261292000494	dimerization interface [polypeptide binding]; other site
261292000495	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
261292000496	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
261292000497	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292000498	ATP binding site [chemical binding]; other site
261292000499	G-X-G motif; other site
261292000500	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
261292000501	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
261292000502	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
261292000503	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
261292000504	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
261292000505	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
261292000506	Type II transport protein GspH; Region: GspH; pfam12019
261292000507	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
261292000508	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
261292000509	Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726
261292000510	PilX N-terminal; Region: PilX_N; pfam14341
261292000511	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
261292000512	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
261292000513	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
261292000514	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
261292000515	transcriptional regulator PhoU; Provisional; Region: PRK11115
261292000516	PhoU domain; Region: PhoU; pfam01895
261292000517	PhoU domain; Region: PhoU; pfam01895
261292000518	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
261292000519	tetramer (dimer of dimers) interface [polypeptide binding]; other site
261292000520	active site
261292000521	dimer interface [polypeptide binding]; other site
261292000522	Transposase domain (DUF772); Region: DUF772; pfam05598
261292000523	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
261292000524	SnoaL-like domain; Region: SnoaL_2; pfam12680
261292000525	hypothetical protein; Validated; Region: PRK02101
261292000526	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
261292000527	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
261292000528	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
261292000529	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
261292000530	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
261292000531	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
261292000532	protein binding site [polypeptide binding]; other site
261292000533	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
261292000534	protein binding site [polypeptide binding]; other site
261292000535	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
261292000536	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
261292000537	metal binding site [ion binding]; metal-binding site
261292000538	putative dimer interface [polypeptide binding]; other site
261292000539	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
261292000540	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
261292000541	Protein of unknown function (DUF497); Region: DUF497; pfam04365
261292000542	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
261292000543	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
261292000544	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
261292000545	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
261292000546	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
261292000547	ATP binding site [chemical binding]; other site
261292000548	putative Mg++ binding site [ion binding]; other site
261292000549	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
261292000550	nucleotide binding region [chemical binding]; other site
261292000551	ATP-binding site [chemical binding]; other site
261292000552	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
261292000553	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
261292000554	catalytic core [active]
261292000555	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
261292000556	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
261292000557	putative active site [active]
261292000558	MgtC family; Region: MgtC; pfam02308
261292000559	Predicted membrane protein [Function unknown]; Region: COG3174
261292000560	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
261292000561	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
261292000562	DHH family; Region: DHH; pfam01368
261292000563	DHHA1 domain; Region: DHHA1; pfam02272
261292000564	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
261292000565	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
261292000566	Transporter associated domain; Region: CorC_HlyC; smart01091
261292000567	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
261292000568	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
261292000569	PhoH-like protein; Region: PhoH; pfam02562
261292000570	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
261292000571	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
261292000572	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
261292000573	FeS/SAM binding site; other site
261292000574	TRAM domain; Region: TRAM; pfam01938
261292000575	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
261292000576	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
261292000577	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
261292000578	ATP binding site [chemical binding]; other site
261292000579	putative Mg++ binding site [ion binding]; other site
261292000580	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
261292000581	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
261292000582	ADP-ribose binding site [chemical binding]; other site
261292000583	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
261292000584	HsdM N-terminal domain; Region: HsdM_N; pfam12161
261292000585	Methyltransferase domain; Region: Methyltransf_26; pfam13659
261292000586	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
261292000587	PEP-CTERM motif; Region: VPEP; pfam07589
261292000588	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608
261292000589	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
261292000590	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
261292000591	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
261292000592	dimerization domain [polypeptide binding]; other site
261292000593	dimer interface [polypeptide binding]; other site
261292000594	catalytic residues [active]
261292000595	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
261292000596	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
261292000597	MltA specific insert domain; Region: MltA; smart00925
261292000598	3D domain; Region: 3D; pfam06725
261292000599	Uncharacterized conserved protein [Function unknown]; Region: COG0327
261292000600	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
261292000601	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
261292000602	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
261292000603	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
261292000604	protein binding site [polypeptide binding]; other site
261292000605	folate/biopterin transporter; Region: fbt; TIGR00788
261292000606	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
261292000607	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
261292000608	cysteine synthase B; Region: cysM; TIGR01138
261292000609	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
261292000610	dimer interface [polypeptide binding]; other site
261292000611	pyridoxal 5'-phosphate binding site [chemical binding]; other site
261292000612	catalytic residue [active]
261292000613	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
261292000614	active site
261292000615	TolQ protein; Region: tolQ; TIGR02796
261292000616	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
261292000617	TolR protein; Region: tolR; TIGR02801
261292000618	TolA protein; Region: tolA_full; TIGR02794
261292000619	TonB C terminal; Region: TonB_2; pfam13103
261292000620	translocation protein TolB; Provisional; Region: tolB; PRK02889
261292000621	TolB amino-terminal domain; Region: TolB_N; pfam04052
261292000622	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
261292000623	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
261292000624	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
261292000625	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
261292000626	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
261292000627	ligand binding site [chemical binding]; other site
261292000628	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
261292000629	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
261292000630	binding surface
261292000631	TPR motif; other site
261292000632	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349
261292000633	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
261292000634	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
261292000635	Ligand Binding Site [chemical binding]; other site
261292000636	Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735
261292000637	metal binding site 2 [ion binding]; metal-binding site
261292000638	putative DNA binding helix; other site
261292000639	metal binding site 1 [ion binding]; metal-binding site
261292000640	dimer interface [polypeptide binding]; other site
261292000641	structural Zn2+ binding site [ion binding]; other site
261292000642	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
261292000643	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
261292000644	CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080
261292000645	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
261292000646	cyclase homology domain; Region: CHD; cd07302
261292000647	nucleotidyl binding site; other site
261292000648	metal binding site [ion binding]; metal-binding site
261292000649	dimer interface [polypeptide binding]; other site
261292000650	FecR protein; Region: FecR; pfam04773
261292000651	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
261292000652	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
261292000653	binding surface
261292000654	TPR motif; other site
261292000655	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
261292000656	binding surface
261292000657	TPR motif; other site
261292000658	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
261292000659	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
261292000660	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
261292000661	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
261292000662	6-phosphofructokinase; Provisional; Region: PRK14072
261292000663	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
261292000664	active site
261292000665	ADP/pyrophosphate binding site [chemical binding]; other site
261292000666	dimerization interface [polypeptide binding]; other site
261292000667	allosteric effector site; other site
261292000668	fructose-1,6-bisphosphate binding site; other site
261292000669	adenylate kinase; Reviewed; Region: adk; PRK00279
261292000670	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
261292000671	AMP-binding site [chemical binding]; other site
261292000672	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
261292000673	recombinase A; Provisional; Region: recA; PRK09354
261292000674	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
261292000675	hexamer interface [polypeptide binding]; other site
261292000676	Walker A motif; other site
261292000677	ATP binding site [chemical binding]; other site
261292000678	Walker B motif; other site
261292000679	recombination regulator RecX; Reviewed; Region: recX; PRK00117
261292000680	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
261292000681	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
261292000682	motif 1; other site
261292000683	active site
261292000684	motif 2; other site
261292000685	motif 3; other site
261292000686	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
261292000687	DHHA1 domain; Region: DHHA1; pfam02272
261292000688	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818
261292000689	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
261292000690	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
261292000691	active site
261292000692	DNA binding site [nucleotide binding]
261292000693	Int/Topo IB signature motif; other site
261292000694	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
261292000695	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
261292000696	AAA domain; Region: AAA_25; pfam13481
261292000697	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
261292000698	Walker A motif; other site
261292000699	ATP binding site [chemical binding]; other site
261292000700	Walker B motif; other site
261292000701	Homeodomain-like domain; Region: HTH_23; pfam13384
261292000702	Poxvirus I6-like family; Region: Pox_I6; cl17808
261292000703	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
261292000704	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
261292000705	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
261292000706	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
261292000707	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
261292000708	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
261292000709	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
261292000710	DNA binding residues [nucleotide binding]
261292000711	DNA primase; Validated; Region: dnaG; PRK05667
261292000712	CHC2 zinc finger; Region: zf-CHC2; pfam01807
261292000713	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
261292000714	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
261292000715	active site
261292000716	metal binding site [ion binding]; metal-binding site
261292000717	interdomain interaction site; other site
261292000718	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
261292000719	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
261292000720	Yqey-like protein; Region: YqeY; pfam09424
261292000721	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
261292000722	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
261292000723	Transposase; Region: HTH_Tnp_1; pfam01527
261292000724	putative transposase OrfB; Reviewed; Region: PHA02517
261292000725	HTH-like domain; Region: HTH_21; pfam13276
261292000726	Integrase core domain; Region: rve; pfam00665
261292000727	Integrase core domain; Region: rve_3; pfam13683
261292000728	choice-of-anchor C domain; Region: choice_anch_C; TIGR04362
261292000729	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
261292000730	active site
261292000731	DNA binding site [nucleotide binding]
261292000732	Int/Topo IB signature motif; other site
261292000733	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
261292000734	salt bridge; other site
261292000735	non-specific DNA binding site [nucleotide binding]; other site
261292000736	sequence-specific DNA binding site [nucleotide binding]; other site
261292000737	putative transposase OrfB; Reviewed; Region: PHA02517
261292000738	HTH-like domain; Region: HTH_21; pfam13276
261292000739	Integrase core domain; Region: rve; pfam00665
261292000740	Integrase core domain; Region: rve_3; pfam13683
261292000741	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
261292000742	Transposase; Region: HTH_Tnp_1; pfam01527
261292000743	Domain of unknown function (DUF2383); Region: DUF2383; cl17556
261292000744	Transposase; Region: HTH_Tnp_1; pfam01527
261292000745	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
261292000746	putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606
261292000747	Protein of unknown function (DUF2846); Region: DUF2846; pfam11008
261292000748	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
261292000749	Sel1 repeat; Region: Sel1; cl02723
261292000750	Sel1-like repeats; Region: SEL1; smart00671
261292000751	Sel1-like repeats; Region: SEL1; smart00671
261292000752	Sel1-like repeats; Region: SEL1; smart00671
261292000753	Sel1-like repeats; Region: SEL1; smart00671
261292000754	Transposase; Region: HTH_Tnp_1; pfam01527
261292000755	putative transposase OrfB; Reviewed; Region: PHA02517
261292000756	HTH-like domain; Region: HTH_21; pfam13276
261292000757	Integrase core domain; Region: rve; pfam00665
261292000758	Integrase core domain; Region: rve_3; cl15866
261292000759	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
261292000760	Sel1-like repeats; Region: SEL1; smart00671
261292000761	Protein of unknown function (DUF466); Region: DUF466; pfam04328
261292000762	carbon starvation protein A; Provisional; Region: PRK15015
261292000763	Carbon starvation protein CstA; Region: CstA; pfam02554
261292000764	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
261292000765	Uncharacterized conserved protein [Function unknown]; Region: COG4278
261292000766	Response regulator receiver domain; Region: Response_reg; pfam00072
261292000767	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292000768	active site
261292000769	phosphorylation site [posttranslational modification]
261292000770	intermolecular recognition site; other site
261292000771	dimerization interface [polypeptide binding]; other site
261292000772	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
261292000773	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
261292000774	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292000775	ATP binding site [chemical binding]; other site
261292000776	Mg2+ binding site [ion binding]; other site
261292000777	G-X-G motif; other site
261292000778	transcriptional regulator NarP; Provisional; Region: PRK10403
261292000779	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292000780	active site
261292000781	phosphorylation site [posttranslational modification]
261292000782	intermolecular recognition site; other site
261292000783	dimerization interface [polypeptide binding]; other site
261292000784	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
261292000785	DNA binding residues [nucleotide binding]
261292000786	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
261292000787	glyceraldehyde-3-phosphate dehydrogenase, type II; Region: GAPDH-II_archae; TIGR01546
261292000788	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
261292000789	Transposase; Region: DEDD_Tnp_IS110; pfam01548
261292000790	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
261292000791	Transposase domain (DUF772); Region: DUF772; pfam05598
261292000792	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
261292000793	DDE superfamily endonuclease; Region: DDE_4; cl17710
261292000794	transposase/IS protein; Provisional; Region: PRK09183
261292000795	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
261292000796	Walker A motif; other site
261292000797	ATP binding site [chemical binding]; other site
261292000798	Walker B motif; other site
261292000799	arginine finger; other site
261292000800	Transposase; Region: HTH_Tnp_1; pfam01527
261292000801	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
261292000802	Response regulator receiver domain; Region: Response_reg; pfam00072
261292000803	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292000804	active site
261292000805	phosphorylation site [posttranslational modification]
261292000806	intermolecular recognition site; other site
261292000807	dimerization interface [polypeptide binding]; other site
261292000808	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
261292000809	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
261292000810	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
261292000811	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292000812	ATP binding site [chemical binding]; other site
261292000813	Mg2+ binding site [ion binding]; other site
261292000814	G-X-G motif; other site
261292000815	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
261292000816	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
261292000817	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
261292000818	Active Sites [active]
261292000819	peroxidase; Provisional; Region: PRK15000
261292000820	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
261292000821	dimer interface [polypeptide binding]; other site
261292000822	decamer (pentamer of dimers) interface [polypeptide binding]; other site
261292000823	catalytic triad [active]
261292000824	peroxidatic and resolving cysteines [active]
261292000825	Protein of unknown function, DUF393; Region: DUF393; pfam04134
261292000826	Protein of unknown function (DUF3296); Region: DUF3296; pfam11726
261292000827	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
261292000828	YqaJ-like viral recombinase domain; Region: YqaJ; cl09232
261292000829	phage/plasmid-like protein TIGR03299; Region: LGT_TIGR03299
261292000830	Domain of unknown function (DUF3482); Region: DUF3482; pfam11981
261292000831	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
261292000832	putative active site [active]
261292000833	catalytic site [active]
261292000834	DEAD-like helicases superfamily; Region: DEXDc; smart00487
261292000835	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
261292000836	ATP binding site [chemical binding]; other site
261292000837	putative Mg++ binding site [ion binding]; other site
261292000838	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
261292000839	nucleotide binding region [chemical binding]; other site
261292000840	ATP-binding site [chemical binding]; other site
261292000841	Domain of unknown function (DUF4391); Region: DUF4391; pfam14335
261292000842	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
261292000843	DNA methylase; Region: N6_N4_Mtase; pfam01555
261292000844	DNA methylase; Region: N6_N4_Mtase; cl17433
261292000845	Protein of unknown function DUF262; Region: DUF262; pfam03235
261292000846	Uncharacterized conserved protein [Function unknown]; Region: COG1479
261292000847	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
261292000848	Restriction endonuclease [Defense mechanisms]; Region: COG3587
261292000849	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
261292000850	ATP binding site [chemical binding]; other site
261292000851	Pirin-related protein [General function prediction only]; Region: COG1741
261292000852	Pirin; Region: Pirin; pfam02678
261292000853	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
261292000854	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
261292000855	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
261292000856	Transposase domain (DUF772); Region: DUF772; pfam05598
261292000857	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
261292000858	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
261292000859	Catalytic site [active]
261292000860	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
261292000861	active site
261292000862	catalytic site [active]
261292000863	substrate binding site [chemical binding]; other site
261292000864	nucleotide excision repair endonuclease; Provisional; Region: PRK10545
261292000865	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
261292000866	GIY-YIG motif/motif A; other site
261292000867	active site
261292000868	catalytic site [active]
261292000869	putative DNA binding site [nucleotide binding]; other site
261292000870	metal binding site [ion binding]; metal-binding site
261292000871	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
261292000872	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
261292000873	active site
261292000874	DNA binding site [nucleotide binding]
261292000875	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
261292000876	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222
261292000877	RNA/DNA hybrid binding site [nucleotide binding]; other site
261292000878	active site
261292000879	integrase; Provisional; Region: PRK09692
261292000880	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
261292000881	active site
261292000882	Int/Topo IB signature motif; other site
261292000883	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
261292000884	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
261292000885	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
261292000886	DNA binding residues [nucleotide binding]
261292000887	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
261292000888	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
261292000889	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
261292000890	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
261292000891	Walker A/P-loop; other site
261292000892	ATP binding site [chemical binding]; other site
261292000893	Q-loop/lid; other site
261292000894	ABC transporter signature motif; other site
261292000895	Walker B; other site
261292000896	D-loop; other site
261292000897	H-loop/switch region; other site
261292000898	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
261292000899	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
261292000900	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
261292000901	P loop; other site
261292000902	GTP binding site [chemical binding]; other site
261292000903	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
261292000904	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
261292000905	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
261292000906	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
261292000907	Ca2+ binding site [ion binding]; other site
261292000908	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
261292000909	catalytic site [active]
261292000910	putative active site [active]
261292000911	putative substrate binding site [chemical binding]; other site
261292000912	dimer interface [polypeptide binding]; other site
261292000913	Peptidase family M48; Region: Peptidase_M48; pfam01435
261292000914	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
261292000915	aromatic arch; other site
261292000916	DCoH dimer interaction site [polypeptide binding]; other site
261292000917	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
261292000918	DCoH tetramer interaction site [polypeptide binding]; other site
261292000919	substrate binding site [chemical binding]; other site
261292000920	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
261292000921	GTPase RsgA; Reviewed; Region: PRK00098
261292000922	RNA binding site [nucleotide binding]; other site
261292000923	homodimer interface [polypeptide binding]; other site
261292000924	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
261292000925	GTPase/Zn-binding domain interface [polypeptide binding]; other site
261292000926	GTP/Mg2+ binding site [chemical binding]; other site
261292000927	G4 box; other site
261292000928	G5 box; other site
261292000929	G1 box; other site
261292000930	Switch I region; other site
261292000931	G2 box; other site
261292000932	G3 box; other site
261292000933	Switch II region; other site
261292000934	Dihydroneopterin aldolase; Region: FolB; smart00905
261292000935	active site
261292000936	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
261292000937	UGMP family protein; Validated; Region: PRK09604
261292000938	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
261292000939	Protein of unknown function (DUF3460); Region: DUF3460; pfam11943
261292000940	short chain dehydrogenase; Provisional; Region: PRK05993
261292000941	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
261292000942	NADP binding site [chemical binding]; other site
261292000943	active site
261292000944	steroid binding site; other site
261292000945	beta-ketothiolase; Provisional; Region: PRK09051
261292000946	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
261292000947	dimer interface [polypeptide binding]; other site
261292000948	active site
261292000949	ATP synthase I chain; Region: ATP_synt_I; cl09170
261292000950	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
261292000951	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
261292000952	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
261292000953	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
261292000954	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
261292000955	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
261292000956	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
261292000957	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
261292000958	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
261292000959	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
261292000960	beta subunit interaction interface [polypeptide binding]; other site
261292000961	Walker A motif; other site
261292000962	ATP binding site [chemical binding]; other site
261292000963	Walker B motif; other site
261292000964	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
261292000965	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
261292000966	core domain interface [polypeptide binding]; other site
261292000967	delta subunit interface [polypeptide binding]; other site
261292000968	epsilon subunit interface [polypeptide binding]; other site
261292000969	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
261292000970	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
261292000971	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
261292000972	alpha subunit interaction interface [polypeptide binding]; other site
261292000973	Walker A motif; other site
261292000974	ATP binding site [chemical binding]; other site
261292000975	Walker B motif; other site
261292000976	inhibitor binding site; inhibition site
261292000977	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
261292000978	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
261292000979	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
261292000980	gamma subunit interface [polypeptide binding]; other site
261292000981	epsilon subunit interface [polypeptide binding]; other site
261292000982	LBP interface [polypeptide binding]; other site
261292000983	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
261292000984	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
261292000985	Substrate binding site; other site
261292000986	Mg++ binding site; other site
261292000987	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
261292000988	active site
261292000989	substrate binding site [chemical binding]; other site
261292000990	CoA binding site [chemical binding]; other site
261292000991	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
261292000992	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
261292000993	glutaminase active site [active]
261292000994	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
261292000995	dimer interface [polypeptide binding]; other site
261292000996	active site
261292000997	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
261292000998	dimer interface [polypeptide binding]; other site
261292000999	active site
261292001000	hypothetical protein; Validated; Region: PRK00110
261292001001	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
261292001002	active site
261292001003	putative DNA-binding cleft [nucleotide binding]; other site
261292001004	dimer interface [polypeptide binding]; other site
261292001005	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
261292001006	RuvA N terminal domain; Region: RuvA_N; pfam01330
261292001007	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
261292001008	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
261292001009	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
261292001010	Walker A motif; other site
261292001011	ATP binding site [chemical binding]; other site
261292001012	Walker B motif; other site
261292001013	arginine finger; other site
261292001014	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
261292001015	YccA-like proteins; Region: YccA_like; cd10433
261292001016	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
261292001017	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
261292001018	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
261292001019	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
261292001020	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
261292001021	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
261292001022	Subunit I/III interface [polypeptide binding]; other site
261292001023	D-pathway; other site
261292001024	Subunit I/VIIc interface [polypeptide binding]; other site
261292001025	Subunit I/IV interface [polypeptide binding]; other site
261292001026	Subunit I/II interface [polypeptide binding]; other site
261292001027	Low-spin heme (heme a) binding site [chemical binding]; other site
261292001028	Subunit I/VIIa interface [polypeptide binding]; other site
261292001029	Subunit I/VIa interface [polypeptide binding]; other site
261292001030	Dimer interface; other site
261292001031	Putative water exit pathway; other site
261292001032	Binuclear center (heme a3/CuB) [ion binding]; other site
261292001033	K-pathway; other site
261292001034	Subunit I/Vb interface [polypeptide binding]; other site
261292001035	Putative proton exit pathway; other site
261292001036	Subunit I/VIb interface; other site
261292001037	Subunit I/VIc interface [polypeptide binding]; other site
261292001038	Electron transfer pathway; other site
261292001039	Subunit I/VIIIb interface [polypeptide binding]; other site
261292001040	Subunit I/VIIb interface [polypeptide binding]; other site
261292001041	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
261292001042	Protein of unknown function (DUF2970); Region: DUF2970; pfam11174
261292001043	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
261292001044	Subunit III/VIIa interface [polypeptide binding]; other site
261292001045	Phospholipid binding site [chemical binding]; other site
261292001046	Subunit I/III interface [polypeptide binding]; other site
261292001047	Subunit III/VIb interface [polypeptide binding]; other site
261292001048	Subunit III/VIa interface; other site
261292001049	Subunit III/Vb interface [polypeptide binding]; other site
261292001050	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
261292001051	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
261292001052	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
261292001053	UbiA prenyltransferase family; Region: UbiA; pfam01040
261292001054	FAD binding domain; Region: FAD_binding_4; pfam01565
261292001055	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
261292001056	outer membrane lipoprotein; Provisional; Region: PRK11023
261292001057	BON domain; Region: BON; pfam04972
261292001058	BON domain; Region: BON; pfam04972
261292001059	CheW-like domain; Region: CheW; pfam01584
261292001060	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
261292001061	feedback inhibition sensing region; other site
261292001062	homohexameric interface [polypeptide binding]; other site
261292001063	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
261292001064	nucleotide binding site [chemical binding]; other site
261292001065	N-acetyl-L-glutamate binding site [chemical binding]; other site
261292001066	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
261292001067	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
261292001068	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
261292001069	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
261292001070	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
261292001071	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
261292001072	Helix-turn-helix domain; Region: HTH_28; pfam13518
261292001073	Winged helix-turn helix; Region: HTH_29; pfam13551
261292001074	Winged helix-turn helix; Region: HTH_33; pfam13592
261292001075	DDE superfamily endonuclease; Region: DDE_3; pfam13358
261292001076	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
261292001077	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
261292001078	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292001079	active site
261292001080	phosphorylation site [posttranslational modification]
261292001081	intermolecular recognition site; other site
261292001082	dimerization interface [polypeptide binding]; other site
261292001083	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
261292001084	DNA binding site [nucleotide binding]
261292001085	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
261292001086	DNA-binding site [nucleotide binding]; DNA binding site
261292001087	RNA-binding motif; other site
261292001088	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
261292001089	heterotetramer interface [polypeptide binding]; other site
261292001090	active site pocket [active]
261292001091	cleavage site
261292001092	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
261292001093	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
261292001094	Walker A motif; other site
261292001095	ATP binding site [chemical binding]; other site
261292001096	Walker B motif; other site
261292001097	arginine finger; other site
261292001098	hypothetical protein; Provisional; Region: PRK08999
261292001099	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
261292001100	active site
261292001101	8-oxo-dGMP binding site [chemical binding]; other site
261292001102	nudix motif; other site
261292001103	metal binding site [ion binding]; metal-binding site
261292001104	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
261292001105	thiamine phosphate binding site [chemical binding]; other site
261292001106	active site
261292001107	pyrophosphate binding site [ion binding]; other site
261292001108	Protein of unknown function, DUF484; Region: DUF484; cl17449
261292001109	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
261292001110	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
261292001111	metal binding site [ion binding]; metal-binding site
261292001112	active site
261292001113	I-site; other site
261292001114	Domain of unknown function (DUF329); Region: DUF329; pfam03884
261292001115	RNA polymerase factor sigma-70; Validated; Region: PRK09047
261292001116	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
261292001117	DNA binding residues [nucleotide binding]
261292001118	Protein of unknown function (DUF3619); Region: DUF3619; pfam12279
261292001119	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
261292001120	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
261292001121	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
261292001122	Walker A/P-loop; other site
261292001123	ATP binding site [chemical binding]; other site
261292001124	Q-loop/lid; other site
261292001125	ABC transporter signature motif; other site
261292001126	Walker B; other site
261292001127	D-loop; other site
261292001128	H-loop/switch region; other site
261292001129	Domain of unknown function (DUF1854); Region: DUF1854; pfam08909
261292001130	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
261292001131	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
261292001132	trmE is a tRNA modification GTPase; Region: trmE; cd04164
261292001133	G1 box; other site
261292001134	GTP/Mg2+ binding site [chemical binding]; other site
261292001135	Switch I region; other site
261292001136	G2 box; other site
261292001137	Switch II region; other site
261292001138	G3 box; other site
261292001139	G4 box; other site
261292001140	G5 box; other site
261292001141	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
261292001142	membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Region: yidC_nterm; TIGR03593
261292001143	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
261292001144	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
261292001145	Haemolytic domain; Region: Haemolytic; pfam01809
261292001146	Ribonuclease P; Region: Ribonuclease_P; cl00457
261292001147	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
261292001148	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
261292001149	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
261292001150	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
261292001151	E3 interaction surface; other site
261292001152	lipoyl attachment site [posttranslational modification]; other site
261292001153	HlyD family secretion protein; Region: HlyD_3; pfam13437
261292001154	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
261292001155	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
261292001156	Walker A/P-loop; other site
261292001157	ATP binding site [chemical binding]; other site
261292001158	Q-loop/lid; other site
261292001159	ABC transporter signature motif; other site
261292001160	Walker B; other site
261292001161	D-loop; other site
261292001162	H-loop/switch region; other site
261292001163	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
261292001164	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
261292001165	NAD(P) binding site [chemical binding]; other site
261292001166	active site
261292001167	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
261292001168	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
261292001169	Probable Catalytic site; other site
261292001170	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
261292001171	RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526
261292001172	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
261292001173	Ligand binding site; other site
261292001174	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
261292001175	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
261292001176	active site
261292001177	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
261292001178	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
261292001179	Probable Catalytic site; other site
261292001180	metal-binding site
261292001181	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
261292001182	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
261292001183	Probable Catalytic site; other site
261292001184	metal-binding site
261292001185	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610
261292001186	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
261292001187	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
261292001188	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
261292001189	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
261292001190	Walker A/P-loop; other site
261292001191	ATP binding site [chemical binding]; other site
261292001192	Q-loop/lid; other site
261292001193	ABC transporter signature motif; other site
261292001194	Walker B; other site
261292001195	D-loop; other site
261292001196	H-loop/switch region; other site
261292001197	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
261292001198	putative carbohydrate binding site [chemical binding]; other site
261292001199	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
261292001200	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
261292001201	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
261292001202	S-adenosylmethionine binding site [chemical binding]; other site
261292001203	Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119
261292001204	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
261292001205	active site
261292001206	dimer interface [polypeptide binding]; other site
261292001207	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
261292001208	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
261292001209	IHF dimer interface [polypeptide binding]; other site
261292001210	IHF - DNA interface [nucleotide binding]; other site
261292001211	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
261292001212	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
261292001213	RNA binding site [nucleotide binding]; other site
261292001214	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
261292001215	RNA binding site [nucleotide binding]; other site
261292001216	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
261292001217	RNA binding site [nucleotide binding]; other site
261292001218	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
261292001219	RNA binding site [nucleotide binding]; other site
261292001220	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
261292001221	RNA binding site [nucleotide binding]; other site
261292001222	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
261292001223	RNA binding site [nucleotide binding]; other site
261292001224	cytidylate kinase; Provisional; Region: cmk; PRK00023
261292001225	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
261292001226	CMP-binding site; other site
261292001227	The sites determining sugar specificity; other site
261292001228	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
261292001229	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
261292001230	hinge; other site
261292001231	active site
261292001232	DNA topoisomerase III; Validated; Region: PRK08173
261292001233	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
261292001234	active site
261292001235	putative interdomain interaction site [polypeptide binding]; other site
261292001236	putative metal-binding site [ion binding]; other site
261292001237	putative nucleotide binding site [chemical binding]; other site
261292001238	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
261292001239	domain I; other site
261292001240	DNA binding groove [nucleotide binding]
261292001241	phosphate binding site [ion binding]; other site
261292001242	domain II; other site
261292001243	domain III; other site
261292001244	nucleotide binding site [chemical binding]; other site
261292001245	catalytic site [active]
261292001246	domain IV; other site
261292001247	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
261292001248	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
261292001249	Protein of unknown function (DUF494); Region: DUF494; pfam04361
261292001250	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
261292001251	DNA protecting protein DprA; Region: dprA; TIGR00732
261292001252	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
261292001253	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
261292001254	active site
261292001255	catalytic residues [active]
261292001256	metal binding site [ion binding]; metal-binding site
261292001257	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
261292001258	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
261292001259	putative active site [active]
261292001260	substrate binding site [chemical binding]; other site
261292001261	putative cosubstrate binding site; other site
261292001262	catalytic site [active]
261292001263	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
261292001264	substrate binding site [chemical binding]; other site
261292001265	16S rRNA methyltransferase B; Provisional; Region: PRK10901
261292001266	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
261292001267	putative RNA binding site [nucleotide binding]; other site
261292001268	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
261292001269	S-adenosylmethionine binding site [chemical binding]; other site
261292001270	Domain of unknown function (DUF4390); Region: DUF4390; pfam14334
261292001271	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
261292001272	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
261292001273	dimerization interface [polypeptide binding]; other site
261292001274	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
261292001275	dimer interface [polypeptide binding]; other site
261292001276	phosphorylation site [posttranslational modification]
261292001277	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292001278	ATP binding site [chemical binding]; other site
261292001279	Mg2+ binding site [ion binding]; other site
261292001280	G-X-G motif; other site
261292001281	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
261292001282	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292001283	active site
261292001284	phosphorylation site [posttranslational modification]
261292001285	intermolecular recognition site; other site
261292001286	dimerization interface [polypeptide binding]; other site
261292001287	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
261292001288	transketolase; Reviewed; Region: PRK12753
261292001289	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
261292001290	TPP-binding site [chemical binding]; other site
261292001291	dimer interface [polypeptide binding]; other site
261292001292	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
261292001293	PYR/PP interface [polypeptide binding]; other site
261292001294	dimer interface [polypeptide binding]; other site
261292001295	TPP binding site [chemical binding]; other site
261292001296	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
261292001297	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
261292001298	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
261292001299	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
261292001300	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
261292001301	Phosphoglycerate kinase; Region: PGK; pfam00162
261292001302	substrate binding site [chemical binding]; other site
261292001303	hinge regions; other site
261292001304	ADP binding site [chemical binding]; other site
261292001305	catalytic site [active]
261292001306	pyruvate kinase; Provisional; Region: PRK05826
261292001307	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
261292001308	domain interfaces; other site
261292001309	active site
261292001310	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
261292001311	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
261292001312	intersubunit interface [polypeptide binding]; other site
261292001313	active site
261292001314	zinc binding site [ion binding]; other site
261292001315	Na+ binding site [ion binding]; other site
261292001316	DDE superfamily endonuclease; Region: DDE_3; pfam13358
261292001317	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
261292001318	Winged helix-turn helix; Region: HTH_29; pfam13551
261292001319	Winged helix-turn helix; Region: HTH_33; pfam13592
261292001320	oxidative damage protection protein; Provisional; Region: PRK05408
261292001321	N-acetylglutamate synthase; Validated; Region: PRK05279
261292001322	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
261292001323	putative feedback inhibition sensing region; other site
261292001324	putative nucleotide binding site [chemical binding]; other site
261292001325	putative substrate binding site [chemical binding]; other site
261292001326	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
261292001327	Coenzyme A binding pocket [chemical binding]; other site
261292001328	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
261292001329	RNA methyltransferase, RsmE family; Region: TIGR00046
261292001330	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
261292001331	putative catalytic residue [active]
261292001332	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
261292001333	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
261292001334	active site
261292001335	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
261292001336	TrkA-N domain; Region: TrkA_N; pfam02254
261292001337	TrkA-C domain; Region: TrkA_C; pfam02080
261292001338	TrkA-N domain; Region: TrkA_N; pfam02254
261292001339	Cation transport protein; Region: TrkH; cl17365
261292001340	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
261292001341	Response regulator receiver domain; Region: Response_reg; pfam00072
261292001342	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292001343	active site
261292001344	phosphorylation site [posttranslational modification]
261292001345	intermolecular recognition site; other site
261292001346	dimerization interface [polypeptide binding]; other site
261292001347	Ammonia monooxygenase/methane monooxygenase, subunit C; Region: AmoC; pfam04896
261292001348	methane monooxygenase/ammonia monooxygenase, subunit A; Region: CH4_NH3mon_ox_A; TIGR03080
261292001349	methane monooxygenase/ammonia monooxygenase, subunit B; Region: CH4_NH3mon_ox_B; TIGR03079
261292001350	Monooxygenase subunit B protein; Region: Monooxygenase_B; pfam04744
261292001351	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
261292001352	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
261292001353	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
261292001354	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
261292001355	Protein export membrane protein; Region: SecD_SecF; pfam02355
261292001356	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
261292001357	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
261292001358	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
261292001359	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
261292001360	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
261292001361	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
261292001362	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
261292001363	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
261292001364	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
261292001365	PQQ-like domain; Region: PQQ_2; pfam13360
261292001366	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
261292001367	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
261292001368	Walker A/P-loop; other site
261292001369	ATP binding site [chemical binding]; other site
261292001370	Q-loop/lid; other site
261292001371	ABC transporter signature motif; other site
261292001372	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
261292001373	Walker B; other site
261292001374	D-loop; other site
261292001375	ABC transporter; Region: ABC_tran_2; pfam12848
261292001376	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
261292001377	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253
261292001378	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
261292001379	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292001380	active site
261292001381	phosphorylation site [posttranslational modification]
261292001382	intermolecular recognition site; other site
261292001383	dimerization interface [polypeptide binding]; other site
261292001384	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
261292001385	Walker A motif; other site
261292001386	ATP binding site [chemical binding]; other site
261292001387	Walker B motif; other site
261292001388	arginine finger; other site
261292001389	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
261292001390	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
261292001391	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
261292001392	dimer interface [polypeptide binding]; other site
261292001393	phosphorylation site [posttranslational modification]
261292001394	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292001395	ATP binding site [chemical binding]; other site
261292001396	Mg2+ binding site [ion binding]; other site
261292001397	G-X-G motif; other site
261292001398	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
261292001399	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
261292001400	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
261292001401	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
261292001402	FliG C-terminal domain; Region: FliG_C; pfam01706
261292001403	flagellar assembly protein H; Validated; Region: fliH; PRK05687
261292001404	Flagellar assembly protein FliH; Region: FliH; pfam02108
261292001405	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
261292001406	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
261292001407	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
261292001408	Walker A motif/ATP binding site; other site
261292001409	Walker B motif; other site
261292001410	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
261292001411	Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882
261292001412	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
261292001413	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021
261292001414	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
261292001415	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
261292001416	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
261292001417	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
261292001418	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
261292001419	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
261292001420	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
261292001421	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
261292001422	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
261292001423	active site residue [active]
261292001424	acyl-CoA synthetase; Validated; Region: PRK09192
261292001425	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
261292001426	acyl-activating enzyme (AAE) consensus motif; other site
261292001427	active site
261292001428	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
261292001429	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
261292001430	NAD(P) binding site [chemical binding]; other site
261292001431	active site
261292001432	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
261292001433	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
261292001434	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
261292001435	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
261292001436	catalytic residue [active]
261292001437	pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169
261292001438	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
261292001439	selenium donor protein; Region: selD; TIGR00476
261292001440	dimerization interface [polypeptide binding]; other site
261292001441	putative ATP binding site [chemical binding]; other site
261292001442	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
261292001443	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
261292001444	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
261292001445	FeS/SAM binding site; other site
261292001446	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
261292001447	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
261292001448	active site
261292001449	hopanoid biosynthesis associated membrane protein HpnM; Region: HpnM; TIGR03481
261292001450	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
261292001451	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
261292001452	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
261292001453	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
261292001454	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
261292001455	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
261292001456	active site
261292001457	substrate binding site [chemical binding]; other site
261292001458	cosubstrate binding site; other site
261292001459	catalytic site [active]
261292001460	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
261292001461	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
261292001462	dimerization interface [polypeptide binding]; other site
261292001463	putative ATP binding site [chemical binding]; other site
261292001464	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
261292001465	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
261292001466	inhibitor-cofactor binding pocket; inhibition site
261292001467	pyridoxal 5'-phosphate binding site [chemical binding]; other site
261292001468	catalytic residue [active]
261292001469	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
261292001470	Domain of unknown function DUF20; Region: UPF0118; pfam01594
261292001471	DnaA regulatory inactivator Hda; Validated; Region: PRK08903
261292001472	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
261292001473	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
261292001474	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
261292001475	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
261292001476	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
261292001477	dimer interface [polypeptide binding]; other site
261292001478	putative anticodon binding site; other site
261292001479	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
261292001480	motif 1; other site
261292001481	active site
261292001482	motif 2; other site
261292001483	motif 3; other site
261292001484	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
261292001485	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
261292001486	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
261292001487	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
261292001488	metal binding site [ion binding]; metal-binding site
261292001489	active site
261292001490	I-site; other site
261292001491	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
261292001492	active pocket/dimerization site; other site
261292001493	active site
261292001494	phosphorylation site [posttranslational modification]
261292001495	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
261292001496	dimerization domain swap beta strand [polypeptide binding]; other site
261292001497	regulatory protein interface [polypeptide binding]; other site
261292001498	active site
261292001499	regulatory phosphorylation site [posttranslational modification]; other site
261292001500	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
261292001501	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
261292001502	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
261292001503	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
261292001504	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
261292001505	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
261292001506	Methyltransferase domain; Region: Methyltransf_23; pfam13489
261292001507	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
261292001508	S-adenosylmethionine binding site [chemical binding]; other site
261292001509	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
261292001510	dinuclear metal binding motif [ion binding]; other site
261292001511	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
261292001512	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304
261292001513	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
261292001514	sulfotransferase; Region: PLN02164
261292001515	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
261292001516	Putative addiction module component; Region: Unstab_antitox; pfam09720
261292001517	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
261292001518	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
261292001519	putative active site [active]
261292001520	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
261292001521	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
261292001522	motif II; other site
261292001523	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
261292001524	extended (e) SDRs; Region: SDR_e; cd08946
261292001525	NAD(P) binding site [chemical binding]; other site
261292001526	active site
261292001527	substrate binding site [chemical binding]; other site
261292001528	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172
261292001529	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389
261292001530	putative ligand binding site [chemical binding]; other site
261292001531	putative NAD binding site [chemical binding]; other site
261292001532	catalytic site [active]
261292001533	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
261292001534	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
261292001535	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
261292001536	Ligand binding site; other site
261292001537	oligomer interface; other site
261292001538	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
261292001539	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
261292001540	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
261292001541	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
261292001542	Probable Catalytic site; other site
261292001543	metal-binding site
261292001544	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
261292001545	O-Antigen ligase; Region: Wzy_C; pfam04932
261292001546	Methyltransferase domain; Region: Methyltransf_23; pfam13489
261292001547	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
261292001548	S-adenosylmethionine binding site [chemical binding]; other site
261292001549	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
261292001550	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
261292001551	S-adenosylmethionine binding site [chemical binding]; other site
261292001552	Domain of unknown function (DUF2024); Region: DUF2024; pfam09630
261292001553	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
261292001554	ArsC family; Region: ArsC; pfam03960
261292001555	catalytic residues [active]
261292001556	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
261292001557	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
261292001558	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
261292001559	RimM N-terminal domain; Region: RimM; pfam01782
261292001560	PRC-barrel domain; Region: PRC; pfam05239
261292001561	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
261292001562	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
261292001563	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
261292001564	Cysteine-rich domain; Region: CCG; pfam02754
261292001565	Cysteine-rich domain; Region: CCG; pfam02754
261292001566	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
261292001567	diiron binding motif [ion binding]; other site
261292001568	hypothetical protein; Validated; Region: PRK00228
261292001569	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
261292001570	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
261292001571	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
261292001572	active site
261292001573	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
261292001574	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
261292001575	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
261292001576	dihydroorotase; Provisional; Region: PRK07627
261292001577	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
261292001578	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
261292001579	active site
261292001580	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
261292001581	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
261292001582	active site
261292001583	Zn binding site [ion binding]; other site
261292001584	VacJ like lipoprotein; Region: VacJ; cl01073
261292001585	Rubredoxin [Energy production and conversion]; Region: COG1773
261292001586	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
261292001587	iron binding site [ion binding]; other site
261292001588	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
261292001589	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
261292001590	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
261292001591	intracellular septation protein A; Reviewed; Region: PRK00259
261292001592	YciI-like protein; Reviewed; Region: PRK11370
261292001593	PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616
261292001594	alanine racemase; Reviewed; Region: dadX; PRK03646
261292001595	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
261292001596	active site
261292001597	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
261292001598	substrate binding site [chemical binding]; other site
261292001599	catalytic residues [active]
261292001600	dimer interface [polypeptide binding]; other site
261292001601	lysophospholipid transporter LplT; Provisional; Region: PRK11195
261292001602	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
261292001603	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
261292001604	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
261292001605	ATP binding site [chemical binding]; other site
261292001606	putative Mg++ binding site [ion binding]; other site
261292001607	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
261292001608	nucleotide binding region [chemical binding]; other site
261292001609	ATP-binding site [chemical binding]; other site
261292001610	Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693
261292001611	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
261292001612	dimer interface [polypeptide binding]; other site
261292001613	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
261292001614	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292001615	active site
261292001616	phosphorylation site [posttranslational modification]
261292001617	intermolecular recognition site; other site
261292001618	dimerization interface [polypeptide binding]; other site
261292001619	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
261292001620	DNA binding site [nucleotide binding]
261292001621	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
261292001622	dimerization interface [polypeptide binding]; other site
261292001623	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
261292001624	dimer interface [polypeptide binding]; other site
261292001625	phosphorylation site [posttranslational modification]
261292001626	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292001627	ATP binding site [chemical binding]; other site
261292001628	Mg2+ binding site [ion binding]; other site
261292001629	G-X-G motif; other site
261292001630	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
261292001631	Fe-S cluster binding site [ion binding]; other site
261292001632	active site
261292001633	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
261292001634	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
261292001635	Coenzyme A binding pocket [chemical binding]; other site
261292001636	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
261292001637	Glycoprotease family; Region: Peptidase_M22; pfam00814
261292001638	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
261292001639	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
261292001640	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
261292001641	homotrimer interaction site [polypeptide binding]; other site
261292001642	zinc binding site [ion binding]; other site
261292001643	CDP-binding sites; other site
261292001644	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
261292001645	substrate binding site; other site
261292001646	dimer interface; other site
261292001647	peptide chain release factor 2; Validated; Region: prfB; PRK00578
261292001648	This domain is found in peptide chain release factors; Region: PCRF; smart00937
261292001649	RF-1 domain; Region: RF-1; pfam00472
261292001650	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
261292001651	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
261292001652	tandem repeat interface [polypeptide binding]; other site
261292001653	oligomer interface [polypeptide binding]; other site
261292001654	active site residues [active]
261292001655	dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987
261292001656	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
261292001657	NADP binding site [chemical binding]; other site
261292001658	active site
261292001659	putative substrate binding site [chemical binding]; other site
261292001660	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
261292001661	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
261292001662	NAD binding site [chemical binding]; other site
261292001663	substrate binding site [chemical binding]; other site
261292001664	homodimer interface [polypeptide binding]; other site
261292001665	active site
261292001666	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
261292001667	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
261292001668	Ligand Binding Site [chemical binding]; other site
261292001669	TilS substrate binding domain; Region: TilS; pfam09179
261292001670	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
261292001671	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
261292001672	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
261292001673	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
261292001674	SelR domain; Region: SelR; pfam01641
261292001675	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
261292001676	Cupin superfamily protein; Region: Cupin_4; pfam08007
261292001677	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
261292001678	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
261292001679	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
261292001680	dihydrodipicolinate synthase; Region: dapA; TIGR00674
261292001681	dimer interface [polypeptide binding]; other site
261292001682	active site
261292001683	catalytic residue [active]
261292001684	Transposase domain (DUF772); Region: DUF772; pfam05598
261292001685	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
261292001686	DDE superfamily endonuclease; Region: DDE_4; cl17710
261292001687	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
261292001688	Clp amino terminal domain; Region: Clp_N; pfam02861
261292001689	Clp amino terminal domain; Region: Clp_N; pfam02861
261292001690	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
261292001691	Walker A motif; other site
261292001692	ATP binding site [chemical binding]; other site
261292001693	Walker B motif; other site
261292001694	arginine finger; other site
261292001695	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
261292001696	Walker A motif; other site
261292001697	ATP binding site [chemical binding]; other site
261292001698	Walker B motif; other site
261292001699	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
261292001700	PAS domain; Region: PAS_9; pfam13426
261292001701	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292001702	putative active site [active]
261292001703	heme pocket [chemical binding]; other site
261292001704	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
261292001705	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
261292001706	metal binding site [ion binding]; metal-binding site
261292001707	active site
261292001708	I-site; other site
261292001709	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
261292001710	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
261292001711	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
261292001712	active site
261292001713	FMN binding site [chemical binding]; other site
261292001714	substrate binding site [chemical binding]; other site
261292001715	3Fe-4S cluster binding site [ion binding]; other site
261292001716	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
261292001717	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
261292001718	dimerization interface [polypeptide binding]; other site
261292001719	active site
261292001720	siroheme synthase; Provisional; Region: cysG; PRK10637
261292001721	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
261292001722	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
261292001723	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
261292001724	active site
261292001725	SAM binding site [chemical binding]; other site
261292001726	homodimer interface [polypeptide binding]; other site
261292001727	phosphate binding protein; Region: ptsS_2; TIGR02136
261292001728	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
261292001729	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
261292001730	active site
261292001731	substrate binding site [chemical binding]; other site
261292001732	metal binding site [ion binding]; metal-binding site
261292001733	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
261292001734	dihydropteroate synthase; Region: DHPS; TIGR01496
261292001735	substrate binding pocket [chemical binding]; other site
261292001736	dimer interface [polypeptide binding]; other site
261292001737	inhibitor binding site; inhibition site
261292001738	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
261292001739	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
261292001740	Walker A motif; other site
261292001741	ATP binding site [chemical binding]; other site
261292001742	Walker B motif; other site
261292001743	arginine finger; other site
261292001744	Peptidase family M41; Region: Peptidase_M41; pfam01434
261292001745	FtsJ-like methyltransferase; Region: FtsJ; cl17430
261292001746	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
261292001747	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
261292001748	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
261292001749	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
261292001750	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
261292001751	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
261292001752	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
261292001753	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
261292001754	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
261292001755	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
261292001756	ATP-grasp domain; Region: ATP-grasp_4; cl17255
261292001757	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
261292001758	IMP binding site; other site
261292001759	dimer interface [polypeptide binding]; other site
261292001760	interdomain contacts; other site
261292001761	partial ornithine binding site; other site
261292001762	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
261292001763	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
261292001764	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
261292001765	catalytic site [active]
261292001766	subunit interface [polypeptide binding]; other site
261292001767	pyruvate carboxylase subunit B; Validated; Region: PRK09282
261292001768	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
261292001769	active site
261292001770	catalytic residues [active]
261292001771	metal binding site [ion binding]; metal-binding site
261292001772	homodimer binding site [polypeptide binding]; other site
261292001773	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
261292001774	carboxyltransferase (CT) interaction site; other site
261292001775	biotinylation site [posttranslational modification]; other site
261292001776	pyruvate carboxylase subunit A; Validated; Region: PRK07178
261292001777	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
261292001778	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
261292001779	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
261292001780	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
261292001781	Drosophila melanogaster CG11883 and related proteins, N-terminal metallophosphatase domain; Region: MPP_CG11883_N; cd07406
261292001782	putative active site [active]
261292001783	putative metal binding site [ion binding]; other site
261292001784	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
261292001785	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
261292001786	Cytochrome P450; Region: p450; cl12078
261292001787	Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451
261292001788	Uncharacterized conserved protein [Function unknown]; Region: COG1656
261292001789	Protein of unknown function DUF82; Region: DUF82; pfam01927
261292001790	Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013
261292001791	choice-of-anchor C domain; Region: choice_anch_C; TIGR04362
261292001792	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
261292001793	lipoprotein signal peptidase; Provisional; Region: PRK14787
261292001794	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
261292001795	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
261292001796	active site
261292001797	HIGH motif; other site
261292001798	nucleotide binding site [chemical binding]; other site
261292001799	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
261292001800	active site
261292001801	KMSKS motif; other site
261292001802	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
261292001803	tRNA binding surface [nucleotide binding]; other site
261292001804	anticodon binding site; other site
261292001805	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
261292001806	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
261292001807	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
261292001808	active site
261292001809	Riboflavin kinase; Region: Flavokinase; smart00904
261292001810	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
261292001811	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
261292001812	Transposase [DNA replication, recombination, and repair]; Region: COG5433
261292001813	Transposase [DNA replication, recombination, and repair]; Region: COG5433
261292001814	division inhibitor protein; Provisional; Region: slmA; PRK09480
261292001815	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
261292001816	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
261292001817	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
261292001818	ATP binding site [chemical binding]; other site
261292001819	substrate interface [chemical binding]; other site
261292001820	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
261292001821	C-terminal peptidase (prc); Region: prc; TIGR00225
261292001822	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
261292001823	protein binding site [polypeptide binding]; other site
261292001824	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
261292001825	Catalytic dyad [active]
261292001826	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
261292001827	Peptidase family M23; Region: Peptidase_M23; pfam01551
261292001828	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
261292001829	catalytic core [active]
261292001830	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
261292001831	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
261292001832	active site residue [active]
261292001833	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
261292001834	GSH binding site [chemical binding]; other site
261292001835	catalytic residues [active]
261292001836	preprotein translocase subunit SecB; Validated; Region: PRK05751
261292001837	SecA binding site; other site
261292001838	Preprotein binding site; other site
261292001839	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807
261292001840	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
261292001841	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
261292001842	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
261292001843	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
261292001844	IHF dimer interface [polypeptide binding]; other site
261292001845	IHF - DNA interface [nucleotide binding]; other site
261292001846	SurA N-terminal domain; Region: SurA_N_3; cl07813
261292001847	periplasmic folding chaperone; Provisional; Region: PRK10788
261292001848	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
261292001849	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997
261292001850	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
261292001851	NAD binding site [chemical binding]; other site
261292001852	homotetramer interface [polypeptide binding]; other site
261292001853	homodimer interface [polypeptide binding]; other site
261292001854	substrate binding site [chemical binding]; other site
261292001855	active site
261292001856	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505
261292001857	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
261292001858	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
261292001859	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
261292001860	dimer interface [polypeptide binding]; other site
261292001861	conserved gate region; other site
261292001862	putative PBP binding loops; other site
261292001863	ABC-ATPase subunit interface; other site
261292001864	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
261292001865	CoA binding domain; Region: CoA_binding_2; pfam13380
261292001866	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
261292001867	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
261292001868	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
261292001869	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
261292001870	Coenzyme A binding pocket [chemical binding]; other site
261292001871	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
261292001872	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
261292001873	putative active site [active]
261292001874	Zn binding site [ion binding]; other site
261292001875	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
261292001876	CoenzymeA binding site [chemical binding]; other site
261292001877	subunit interaction site [polypeptide binding]; other site
261292001878	PHB binding site; other site
261292001879	DDE superfamily endonuclease; Region: DDE_3; pfam13358
261292001880	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
261292001881	Winged helix-turn helix; Region: HTH_29; pfam13551
261292001882	Winged helix-turn helix; Region: HTH_33; pfam13592
261292001883	Protein of unknown function (DUF3422); Region: DUF3422; pfam11902
261292001884	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
261292001885	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
261292001886	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
261292001887	PAS domain S-box; Region: sensory_box; TIGR00229
261292001888	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292001889	putative active site [active]
261292001890	heme pocket [chemical binding]; other site
261292001891	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292001892	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
261292001893	putative active site [active]
261292001894	heme pocket [chemical binding]; other site
261292001895	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292001896	putative active site [active]
261292001897	heme pocket [chemical binding]; other site
261292001898	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292001899	PAS domain; Region: PAS_9; pfam13426
261292001900	putative active site [active]
261292001901	heme pocket [chemical binding]; other site
261292001902	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
261292001903	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
261292001904	metal binding site [ion binding]; metal-binding site
261292001905	active site
261292001906	I-site; other site
261292001907	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
261292001908	thiopurine S-methyltransferase; Reviewed; Region: PRK13255
261292001909	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
261292001910	allophanate hydrolase; Provisional; Region: PRK08186
261292001911	Amidase; Region: Amidase; cl11426
261292001912	urea carboxylase; Region: urea_carbox; TIGR02712
261292001913	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
261292001914	ATP-grasp domain; Region: ATP-grasp_4; cl17255
261292001915	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
261292001916	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
261292001917	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
261292001918	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
261292001919	carboxyltransferase (CT) interaction site; other site
261292001920	biotinylation site [posttranslational modification]; other site
261292001921	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
261292001922	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
261292001923	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
261292001924	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
261292001925	permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428
261292001926	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
261292001927	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
261292001928	non-specific DNA binding site [nucleotide binding]; other site
261292001929	salt bridge; other site
261292001930	sequence-specific DNA binding site [nucleotide binding]; other site
261292001931	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
261292001932	homodimer interface [polypeptide binding]; other site
261292001933	pyridoxal 5'-phosphate binding site [chemical binding]; other site
261292001934	catalytic residue [active]
261292001935	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
261292001936	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
261292001937	Mg++ binding site [ion binding]; other site
261292001938	putative catalytic motif [active]
261292001939	putative substrate binding site [chemical binding]; other site
261292001940	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
261292001941	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
261292001942	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
261292001943	NAD(P) binding site [chemical binding]; other site
261292001944	homodimer interface [polypeptide binding]; other site
261292001945	substrate binding site [chemical binding]; other site
261292001946	active site
261292001947	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
261292001948	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
261292001949	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
261292001950	Walker A/P-loop; other site
261292001951	ATP binding site [chemical binding]; other site
261292001952	Q-loop/lid; other site
261292001953	ABC transporter signature motif; other site
261292001954	Walker B; other site
261292001955	D-loop; other site
261292001956	H-loop/switch region; other site
261292001957	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
261292001958	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
261292001959	substrate binding site; other site
261292001960	tetramer interface; other site
261292001961	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
261292001962	DNA repair protein RadA; Provisional; Region: PRK11823
261292001963	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
261292001964	Walker A motif/ATP binding site; other site
261292001965	ATP binding site [chemical binding]; other site
261292001966	Walker B motif; other site
261292001967	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
261292001968	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
261292001969	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
261292001970	ATP binding site [chemical binding]; other site
261292001971	Mg++ binding site [ion binding]; other site
261292001972	motif III; other site
261292001973	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
261292001974	nucleotide binding region [chemical binding]; other site
261292001975	ATP-binding site [chemical binding]; other site
261292001976	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
261292001977	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
261292001978	active site
261292001979	HIGH motif; other site
261292001980	dimer interface [polypeptide binding]; other site
261292001981	KMSKS motif; other site
261292001982	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
261292001983	RNA binding surface [nucleotide binding]; other site
261292001984	putative peptidase; Provisional; Region: PRK11649
261292001985	Peptidase family M23; Region: Peptidase_M23; pfam01551
261292001986	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
261292001987	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
261292001988	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
261292001989	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
261292001990	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
261292001991	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
261292001992	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
261292001993	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
261292001994	23S rRNA interface [nucleotide binding]; other site
261292001995	L3 interface [polypeptide binding]; other site
261292001996	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
261292001997	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
261292001998	active site
261292001999	HIGH motif; other site
261292002000	nucleotide binding site [chemical binding]; other site
261292002001	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
261292002002	KMSKS motif; other site
261292002003	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
261292002004	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
261292002005	active site
261292002006	NTP binding site [chemical binding]; other site
261292002007	metal binding triad [ion binding]; metal-binding site
261292002008	antibiotic binding site [chemical binding]; other site
261292002009	Protein of unknown function DUF86; Region: DUF86; pfam01934
261292002010	TIR domain; Region: TIR_2; pfam13676
261292002011	AAA ATPase domain; Region: AAA_16; pfam13191
261292002012	Tetratricopeptide repeat; Region: TPR_12; pfam13424
261292002013	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
261292002014	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
261292002015	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
261292002016	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
261292002017	RNA binding site [nucleotide binding]; other site
261292002018	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
261292002019	recombination associated protein; Reviewed; Region: rdgC; PRK00321
261292002020	seryl-tRNA synthetase; Provisional; Region: PRK05431
261292002021	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
261292002022	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
261292002023	dimer interface [polypeptide binding]; other site
261292002024	active site
261292002025	motif 1; other site
261292002026	motif 2; other site
261292002027	motif 3; other site
261292002028	recombination factor protein RarA; Reviewed; Region: PRK13342
261292002029	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
261292002030	Walker A motif; other site
261292002031	ATP binding site [chemical binding]; other site
261292002032	Walker B motif; other site
261292002033	arginine finger; other site
261292002034	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
261292002035	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
261292002036	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
261292002037	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
261292002038	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
261292002039	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
261292002040	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
261292002041	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
261292002042	metal binding site [ion binding]; metal-binding site
261292002043	active site
261292002044	I-site; other site
261292002045	RDD family; Region: RDD; pfam06271
261292002046	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
261292002047	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
261292002048	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
261292002049	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
261292002050	TolR protein; Region: tolR; TIGR02801
261292002051	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
261292002052	Secretin and TonB N terminus short domain; Region: STN; smart00965
261292002053	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
261292002054	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
261292002055	N-terminal plug; other site
261292002056	ligand-binding site [chemical binding]; other site
261292002057	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
261292002058	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
261292002059	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
261292002060	active site
261292002061	nucleotide binding site [chemical binding]; other site
261292002062	HIGH motif; other site
261292002063	KMSKS motif; other site
261292002064	PAS domain S-box; Region: sensory_box; TIGR00229
261292002065	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292002066	putative active site [active]
261292002067	heme pocket [chemical binding]; other site
261292002068	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
261292002069	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
261292002070	Walker A motif; other site
261292002071	ATP binding site [chemical binding]; other site
261292002072	Walker B motif; other site
261292002073	arginine finger; other site
261292002074	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
261292002075	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
261292002076	Cytochrome c; Region: Cytochrom_C; cl11414
261292002077	Cytochrome c; Region: Cytochrom_C; cl11414
261292002078	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
261292002079	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
261292002080	Cytochrome c; Region: Cytochrom_C; pfam00034
261292002081	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
261292002082	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
261292002083	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
261292002084	protein binding site [polypeptide binding]; other site
261292002085	thioredoxin 2; Provisional; Region: PRK10996
261292002086	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
261292002087	catalytic residues [active]
261292002088	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
261292002089	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
261292002090	HSP70 interaction site [polypeptide binding]; other site
261292002091	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
261292002092	substrate binding site [polypeptide binding]; other site
261292002093	dimer interface [polypeptide binding]; other site
261292002094	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
261292002095	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
261292002096	PEP-CTERM motif; Region: VPEP; pfam07589
261292002097	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
261292002098	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
261292002099	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
261292002100	HDOD domain; Region: HDOD; pfam08668
261292002101	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
261292002102	Zn2+ binding site [ion binding]; other site
261292002103	Mg2+ binding site [ion binding]; other site
261292002104	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
261292002105	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
261292002106	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
261292002107	Transposase domain (DUF772); Region: DUF772; pfam05598
261292002108	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
261292002109	DDE superfamily endonuclease; Region: DDE_4; cl17710
261292002110	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
261292002111	Zn2+ binding site [ion binding]; other site
261292002112	Mg2+ binding site [ion binding]; other site
261292002113	Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023
261292002114	Protein of unknown function (DUF3579); Region: DUF3579; pfam12112
261292002115	Cytochrome c; Region: Cytochrom_C; pfam00034
261292002116	Outer membrane efflux protein; Region: OEP; pfam02321
261292002117	Outer membrane efflux protein; Region: OEP; pfam02321
261292002118	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
261292002119	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
261292002120	HlyD family secretion protein; Region: HlyD_3; pfam13437
261292002121	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
261292002122	Protein export membrane protein; Region: SecD_SecF; cl14618
261292002123	Protein of unknown function (DUF1504); Region: DUF1504; pfam07399
261292002124	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
261292002125	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
261292002126	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
261292002127	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
261292002128	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
261292002129	metal binding site [ion binding]; metal-binding site
261292002130	active site
261292002131	I-site; other site
261292002132	TIR domain; Region: TIR_2; pfam13676
261292002133	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
261292002134	Uncharacterized conserved protein [Function unknown]; Region: COG1262
261292002135	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
261292002136	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
261292002137	dimer interface [polypeptide binding]; other site
261292002138	ADP-ribose binding site [chemical binding]; other site
261292002139	active site
261292002140	nudix motif; other site
261292002141	metal binding site [ion binding]; metal-binding site
261292002142	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
261292002143	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
261292002144	GAF domain; Region: GAF; pfam01590
261292002145	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292002146	PAS domain; Region: PAS_9; pfam13426
261292002147	putative active site [active]
261292002148	heme pocket [chemical binding]; other site
261292002149	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
261292002150	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
261292002151	metal binding site [ion binding]; metal-binding site
261292002152	active site
261292002153	I-site; other site
261292002154	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
261292002155	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
261292002156	potassium uptake protein; Region: kup; TIGR00794
261292002157	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3055
261292002158	Kelch motif; Region: Kelch_1; pfam01344
261292002159	Kelch motif; Region: Kelch_1; pfam01344
261292002160	Kelch domain; Region: Kelch; smart00612
261292002161	Kelch domain; Region: Kelch; smart00612
261292002162	Kelch domain; Region: Kelch; smart00612
261292002163	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
261292002164	TIGR01777 family protein; Region: yfcH
261292002165	NAD(P) binding site [chemical binding]; other site
261292002166	active site
261292002167	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
261292002168	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
261292002169	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
261292002170	active site
261292002171	Transmembrane secretion effector; Region: MFS_3; pfam05977
261292002172	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
261292002173	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
261292002174	Pirin-related protein [General function prediction only]; Region: COG1741
261292002175	Pirin; Region: Pirin; pfam02678
261292002176	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
261292002177	Isochorismatase family; Region: Isochorismatase; pfam00857
261292002178	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
261292002179	catalytic triad [active]
261292002180	dimer interface [polypeptide binding]; other site
261292002181	conserved cis-peptide bond; other site
261292002182	Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257
261292002183	Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins; Region: TECPR; smart00706
261292002184	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
261292002185	RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145
261292002186	ATP binding site [chemical binding]; other site
261292002187	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
261292002188	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
261292002189	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
261292002190	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
261292002191	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
261292002192	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292002193	active site
261292002194	phosphorylation site [posttranslational modification]
261292002195	intermolecular recognition site; other site
261292002196	dimerization interface [polypeptide binding]; other site
261292002197	EAL domain; Region: EAL; pfam00563
261292002198	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
261292002199	CAAX protease self-immunity; Region: Abi; pfam02517
261292002200	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
261292002201	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
261292002202	Active Sites [active]
261292002203	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
261292002204	TAP-like protein; Region: Abhydrolase_4; pfam08386
261292002205	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
261292002206	active site
261292002207	nucleophile elbow; other site
261292002208	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
261292002209	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
261292002210	Ligand Binding Site [chemical binding]; other site
261292002211	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
261292002212	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
261292002213	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
261292002214	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
261292002215	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
261292002216	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
261292002217	Walker A motif; other site
261292002218	ATP binding site [chemical binding]; other site
261292002219	Walker B motif; other site
261292002220	Pilin (bacterial filament); Region: Pilin; pfam00114
261292002221	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
261292002222	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
261292002223	metal binding triad; other site
261292002224	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
261292002225	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
261292002226	metal binding triad; other site
261292002227	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
261292002228	nitrilase; Region: PLN02798
261292002229	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
261292002230	putative active site [active]
261292002231	catalytic triad [active]
261292002232	dimer interface [polypeptide binding]; other site
261292002233	protease TldD; Provisional; Region: tldD; PRK10735
261292002234	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965
261292002235	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
261292002236	PYR/PP interface [polypeptide binding]; other site
261292002237	dimer interface [polypeptide binding]; other site
261292002238	TPP binding site [chemical binding]; other site
261292002239	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
261292002240	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
261292002241	TPP-binding site [chemical binding]; other site
261292002242	dimer interface [polypeptide binding]; other site
261292002243	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
261292002244	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
261292002245	putative valine binding site [chemical binding]; other site
261292002246	dimer interface [polypeptide binding]; other site
261292002247	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
261292002248	ketol-acid reductoisomerase; Provisional; Region: PRK05479
261292002249	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
261292002250	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
261292002251	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
261292002252	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
261292002253	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
261292002254	2-isopropylmalate synthase; Validated; Region: PRK00915
261292002255	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
261292002256	active site
261292002257	catalytic residues [active]
261292002258	metal binding site [ion binding]; metal-binding site
261292002259	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
261292002260	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
261292002261	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
261292002262	catalytic residues [active]
261292002263	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
261292002264	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
261292002265	N-acetyl-D-glucosamine binding site [chemical binding]; other site
261292002266	catalytic residue [active]
261292002267	prolyl-tRNA synthetase; Provisional; Region: PRK09194
261292002268	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
261292002269	dimer interface [polypeptide binding]; other site
261292002270	motif 1; other site
261292002271	active site
261292002272	motif 2; other site
261292002273	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
261292002274	putative deacylase active site [active]
261292002275	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
261292002276	active site
261292002277	motif 3; other site
261292002278	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
261292002279	anticodon binding site; other site
261292002280	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
261292002281	putative active site [active]
261292002282	Ap4A binding site [chemical binding]; other site
261292002283	nudix motif; other site
261292002284	putative metal binding site [ion binding]; other site
261292002285	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
261292002286	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
261292002287	bacterial Hfq-like; Region: Hfq; cd01716
261292002288	hexamer interface [polypeptide binding]; other site
261292002289	Sm1 motif; other site
261292002290	RNA binding site [nucleotide binding]; other site
261292002291	Sm2 motif; other site
261292002292	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
261292002293	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
261292002294	HflX GTPase family; Region: HflX; cd01878
261292002295	G1 box; other site
261292002296	GTP/Mg2+ binding site [chemical binding]; other site
261292002297	Switch I region; other site
261292002298	G2 box; other site
261292002299	G3 box; other site
261292002300	Switch II region; other site
261292002301	G4 box; other site
261292002302	G5 box; other site
261292002303	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
261292002304	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
261292002305	HflK protein; Region: hflK; TIGR01933
261292002306	HflC protein; Region: hflC; TIGR01932
261292002307	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
261292002308	Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838
261292002309	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
261292002310	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
261292002311	dimer interface [polypeptide binding]; other site
261292002312	motif 1; other site
261292002313	active site
261292002314	motif 2; other site
261292002315	motif 3; other site
261292002316	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
261292002317	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
261292002318	GDP-binding site [chemical binding]; other site
261292002319	ACT binding site; other site
261292002320	IMP binding site; other site
261292002321	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
261292002322	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
261292002323	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
261292002324	Coenzyme A binding pocket [chemical binding]; other site
261292002325	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
261292002326	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
261292002327	Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447
261292002328	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
261292002329	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
261292002330	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
261292002331	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
261292002332	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
261292002333	ATP binding site [chemical binding]; other site
261292002334	Mg++ binding site [ion binding]; other site
261292002335	motif III; other site
261292002336	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
261292002337	nucleotide binding region [chemical binding]; other site
261292002338	ATP-binding site [chemical binding]; other site
261292002339	elongation factor Tu; Reviewed; Region: PRK00049
261292002340	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
261292002341	G1 box; other site
261292002342	GEF interaction site [polypeptide binding]; other site
261292002343	GTP/Mg2+ binding site [chemical binding]; other site
261292002344	Switch I region; other site
261292002345	G2 box; other site
261292002346	G3 box; other site
261292002347	Switch II region; other site
261292002348	G4 box; other site
261292002349	G5 box; other site
261292002350	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
261292002351	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
261292002352	Antibiotic Binding Site [chemical binding]; other site
261292002353	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
261292002354	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
261292002355	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
261292002356	putative homodimer interface [polypeptide binding]; other site
261292002357	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
261292002358	heterodimer interface [polypeptide binding]; other site
261292002359	homodimer interface [polypeptide binding]; other site
261292002360	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
261292002361	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
261292002362	23S rRNA interface [nucleotide binding]; other site
261292002363	L7/L12 interface [polypeptide binding]; other site
261292002364	putative thiostrepton binding site; other site
261292002365	L25 interface [polypeptide binding]; other site
261292002366	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
261292002367	mRNA/rRNA interface [nucleotide binding]; other site
261292002368	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
261292002369	23S rRNA interface [nucleotide binding]; other site
261292002370	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
261292002371	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
261292002372	peripheral dimer interface [polypeptide binding]; other site
261292002373	core dimer interface [polypeptide binding]; other site
261292002374	L10 interface [polypeptide binding]; other site
261292002375	L11 interface [polypeptide binding]; other site
261292002376	putative EF-Tu interaction site [polypeptide binding]; other site
261292002377	putative EF-G interaction site [polypeptide binding]; other site
261292002378	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
261292002379	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
261292002380	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
261292002381	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
261292002382	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
261292002383	RPB12 interaction site [polypeptide binding]; other site
261292002384	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
261292002385	RPB3 interaction site [polypeptide binding]; other site
261292002386	RPB1 interaction site [polypeptide binding]; other site
261292002387	RPB11 interaction site [polypeptide binding]; other site
261292002388	RPB10 interaction site [polypeptide binding]; other site
261292002389	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
261292002390	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
261292002391	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
261292002392	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
261292002393	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
261292002394	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
261292002395	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
261292002396	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
261292002397	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
261292002398	DNA binding site [nucleotide binding]
261292002399	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
261292002400	Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447
261292002401	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
261292002402	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
261292002403	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
261292002404	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
261292002405	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
261292002406	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
261292002407	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
261292002408	active site
261292002409	dimer interface [polypeptide binding]; other site
261292002410	motif 1; other site
261292002411	motif 2; other site
261292002412	motif 3; other site
261292002413	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
261292002414	anticodon binding site; other site
261292002415	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
261292002416	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
261292002417	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
261292002418	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
261292002419	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
261292002420	23S rRNA binding site [nucleotide binding]; other site
261292002421	L21 binding site [polypeptide binding]; other site
261292002422	L13 binding site [polypeptide binding]; other site
261292002423	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
261292002424	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
261292002425	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
261292002426	dimer interface [polypeptide binding]; other site
261292002427	motif 1; other site
261292002428	active site
261292002429	motif 2; other site
261292002430	motif 3; other site
261292002431	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
261292002432	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
261292002433	putative tRNA-binding site [nucleotide binding]; other site
261292002434	B3/4 domain; Region: B3_4; pfam03483
261292002435	tRNA synthetase B5 domain; Region: B5; smart00874
261292002436	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
261292002437	dimer interface [polypeptide binding]; other site
261292002438	motif 1; other site
261292002439	motif 3; other site
261292002440	motif 2; other site
261292002441	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
261292002442	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
261292002443	IHF dimer interface [polypeptide binding]; other site
261292002444	IHF - DNA interface [nucleotide binding]; other site
261292002445	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
261292002446	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
261292002447	DNA binding residues [nucleotide binding]
261292002448	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
261292002449	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
261292002450	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
261292002451	S-adenosylmethionine binding site [chemical binding]; other site
261292002452	lipoprotein NlpD; Provisional; Region: nlpD; PRK10871
261292002453	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
261292002454	Peptidase family M23; Region: Peptidase_M23; pfam01551
261292002455	aminotransferase AlaT; Validated; Region: PRK09265
261292002456	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
261292002457	pyridoxal 5'-phosphate binding site [chemical binding]; other site
261292002458	homodimer interface [polypeptide binding]; other site
261292002459	catalytic residue [active]
261292002460	homoserine dehydrogenase; Provisional; Region: PRK06349
261292002461	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
261292002462	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
261292002463	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
261292002464	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
261292002465	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
261292002466	pyridoxal 5'-phosphate binding site [chemical binding]; other site
261292002467	catalytic residue [active]
261292002468	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
261292002469	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
261292002470	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
261292002471	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
261292002472	Uncharacterized conserved protein [Function unknown]; Region: COG2938
261292002473	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
261292002474	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
261292002475	dimer interface [polypeptide binding]; other site
261292002476	active site
261292002477	citrylCoA binding site [chemical binding]; other site
261292002478	NADH binding [chemical binding]; other site
261292002479	cationic pore residues; other site
261292002480	oxalacetate/citrate binding site [chemical binding]; other site
261292002481	coenzyme A binding site [chemical binding]; other site
261292002482	catalytic triad [active]
261292002483	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
261292002484	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
261292002485	TPP-binding site [chemical binding]; other site
261292002486	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
261292002487	dimer interface [polypeptide binding]; other site
261292002488	PYR/PP interface [polypeptide binding]; other site
261292002489	TPP binding site [chemical binding]; other site
261292002490	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
261292002491	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
261292002492	E3 interaction surface; other site
261292002493	lipoyl attachment site [posttranslational modification]; other site
261292002494	e3 binding domain; Region: E3_binding; pfam02817
261292002495	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
261292002496	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
261292002497	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
261292002498	ligand binding site [chemical binding]; other site
261292002499	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
261292002500	putative switch regulator; other site
261292002501	non-specific DNA interactions [nucleotide binding]; other site
261292002502	DNA binding site [nucleotide binding]
261292002503	sequence specific DNA binding site [nucleotide binding]; other site
261292002504	putative cAMP binding site [chemical binding]; other site
261292002505	Response regulator receiver domain; Region: Response_reg; pfam00072
261292002506	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292002507	active site
261292002508	phosphorylation site [posttranslational modification]
261292002509	intermolecular recognition site; other site
261292002510	dimerization interface [polypeptide binding]; other site
261292002511	PAS domain S-box; Region: sensory_box; TIGR00229
261292002512	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
261292002513	putative active site [active]
261292002514	heme pocket [chemical binding]; other site
261292002515	PAS domain S-box; Region: sensory_box; TIGR00229
261292002516	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292002517	putative active site [active]
261292002518	heme pocket [chemical binding]; other site
261292002519	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292002520	PAS domain; Region: PAS_9; pfam13426
261292002521	putative active site [active]
261292002522	heme pocket [chemical binding]; other site
261292002523	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
261292002524	dimer interface [polypeptide binding]; other site
261292002525	phosphorylation site [posttranslational modification]
261292002526	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292002527	ATP binding site [chemical binding]; other site
261292002528	Mg2+ binding site [ion binding]; other site
261292002529	G-X-G motif; other site
261292002530	Response regulator receiver domain; Region: Response_reg; pfam00072
261292002531	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292002532	active site
261292002533	phosphorylation site [posttranslational modification]
261292002534	intermolecular recognition site; other site
261292002535	dimerization interface [polypeptide binding]; other site
261292002536	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
261292002537	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
261292002538	putative active site [active]
261292002539	putative PHP Thumb interface [polypeptide binding]; other site
261292002540	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
261292002541	generic binding surface II; other site
261292002542	generic binding surface I; other site
261292002543	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
261292002544	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292002545	PAS domain; Region: PAS_9; pfam13426
261292002546	putative active site [active]
261292002547	heme pocket [chemical binding]; other site
261292002548	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
261292002549	dimerization interface [polypeptide binding]; other site
261292002550	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
261292002551	dimer interface [polypeptide binding]; other site
261292002552	putative CheW interface [polypeptide binding]; other site
261292002553	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
261292002554	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292002555	putative active site [active]
261292002556	heme pocket [chemical binding]; other site
261292002557	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
261292002558	dimer interface [polypeptide binding]; other site
261292002559	phosphorylation site [posttranslational modification]
261292002560	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292002561	ATP binding site [chemical binding]; other site
261292002562	Mg2+ binding site [ion binding]; other site
261292002563	G-X-G motif; other site
261292002564	Response regulator receiver domain; Region: Response_reg; pfam00072
261292002565	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292002566	active site
261292002567	phosphorylation site [posttranslational modification]
261292002568	intermolecular recognition site; other site
261292002569	dimerization interface [polypeptide binding]; other site
261292002570	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
261292002571	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292002572	active site
261292002573	phosphorylation site [posttranslational modification]
261292002574	intermolecular recognition site; other site
261292002575	dimerization interface [polypeptide binding]; other site
261292002576	PAS domain S-box; Region: sensory_box; TIGR00229
261292002577	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292002578	putative active site [active]
261292002579	heme pocket [chemical binding]; other site
261292002580	Histidine kinase; Region: HisKA_3; pfam07730
261292002581	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
261292002582	ATP binding site [chemical binding]; other site
261292002583	Mg2+ binding site [ion binding]; other site
261292002584	G-X-G motif; other site
261292002585	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
261292002586	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292002587	active site
261292002588	phosphorylation site [posttranslational modification]
261292002589	intermolecular recognition site; other site
261292002590	dimerization interface [polypeptide binding]; other site
261292002591	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
261292002592	DNA binding residues [nucleotide binding]
261292002593	dimerization interface [polypeptide binding]; other site
261292002594	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
261292002595	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
261292002596	dimer interface [polypeptide binding]; other site
261292002597	[2Fe-2S] cluster binding site [ion binding]; other site
261292002598	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
261292002599	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
261292002600	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
261292002601	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
261292002602	dimer interface [polypeptide binding]; other site
261292002603	conserved gate region; other site
261292002604	putative PBP binding loops; other site
261292002605	ABC-ATPase subunit interface; other site
261292002606	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
261292002607	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
261292002608	dimer interface [polypeptide binding]; other site
261292002609	conserved gate region; other site
261292002610	putative PBP binding loops; other site
261292002611	ABC-ATPase subunit interface; other site
261292002612	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
261292002613	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
261292002614	Walker A/P-loop; other site
261292002615	ATP binding site [chemical binding]; other site
261292002616	Q-loop/lid; other site
261292002617	ABC transporter signature motif; other site
261292002618	Walker B; other site
261292002619	D-loop; other site
261292002620	H-loop/switch region; other site
261292002621	TOBE domain; Region: TOBE_2; pfam08402
261292002622	SnoaL-like domain; Region: SnoaL_2; pfam12680
261292002623	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
261292002624	Lipase (class 2); Region: Lipase_2; pfam01674
261292002625	Putative serine esterase (DUF676); Region: DUF676; pfam05057
261292002626	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
261292002627	Fatty acid desaturase; Region: FA_desaturase; pfam00487
261292002628	putative di-iron ligands [ion binding]; other site
261292002629	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
261292002630	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
261292002631	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
261292002632	SCP-2 sterol transfer family; Region: SCP2; pfam02036
261292002633	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
261292002634	Fic/DOC family; Region: Fic; cl00960
261292002635	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
261292002636	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
261292002637	metal binding triad [ion binding]; metal-binding site
261292002638	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl17552
261292002639	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
261292002640	HsdM N-terminal domain; Region: HsdM_N; pfam12161
261292002641	Methyltransferase domain; Region: Methyltransf_26; pfam13659
261292002642	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
261292002643	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
261292002644	GatB domain; Region: GatB_Yqey; smart00845
261292002645	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
261292002646	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
261292002647	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
261292002648	rod shape-determining protein MreB; Provisional; Region: PRK13927
261292002649	MreB and similar proteins; Region: MreB_like; cd10225
261292002650	nucleotide binding site [chemical binding]; other site
261292002651	Mg binding site [ion binding]; other site
261292002652	putative protofilament interaction site [polypeptide binding]; other site
261292002653	RodZ interaction site [polypeptide binding]; other site
261292002654	rod shape-determining protein MreC; Provisional; Region: PRK13922
261292002655	rod shape-determining protein MreC; Region: MreC; pfam04085
261292002656	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
261292002657	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
261292002658	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
261292002659	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
261292002660	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
261292002661	rare lipoprotein A; Region: rlpA; TIGR00413
261292002662	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
261292002663	Sporulation related domain; Region: SPOR; pfam05036
261292002664	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
261292002665	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
261292002666	motif II; other site
261292002667	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
261292002668	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
261292002669	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
261292002670	PLD-like domain; Region: PLDc_2; pfam13091
261292002671	putative active site [active]
261292002672	catalytic site [active]
261292002673	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
261292002674	PLD-like domain; Region: PLDc_2; pfam13091
261292002675	putative active site [active]
261292002676	catalytic site [active]
261292002677	quinolinate synthetase; Provisional; Region: PRK09375
261292002678	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
261292002679	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200
261292002680	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
261292002681	OstA-like protein; Region: OstA; pfam03968
261292002682	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
261292002683	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
261292002684	Walker A/P-loop; other site
261292002685	ATP binding site [chemical binding]; other site
261292002686	Q-loop/lid; other site
261292002687	ABC transporter signature motif; other site
261292002688	Walker B; other site
261292002689	D-loop; other site
261292002690	H-loop/switch region; other site
261292002691	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
261292002692	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
261292002693	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
261292002694	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
261292002695	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
261292002696	30S subunit binding site; other site
261292002697	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
261292002698	active site
261292002699	phosphorylation site [posttranslational modification]
261292002700	HPr kinase/phosphorylase; Provisional; Region: PRK05428
261292002701	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
261292002702	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
261292002703	Hpr binding site; other site
261292002704	active site
261292002705	homohexamer subunit interaction site [polypeptide binding]; other site
261292002706	aromatic acid decarboxylase; Validated; Region: PRK05920
261292002707	Flavoprotein; Region: Flavoprotein; pfam02441
261292002708	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
261292002709	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
261292002710	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
261292002711	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
261292002712	minor groove reading motif; other site
261292002713	helix-hairpin-helix signature motif; other site
261292002714	substrate binding pocket [chemical binding]; other site
261292002715	active site
261292002716	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
261292002717	DNA binding and oxoG recognition site [nucleotide binding]
261292002718	Modulator of Rho-dependent transcription termination (ROF); Region: ROF; pfam07073
261292002719	hypothetical protein; Provisional; Region: PRK02237
261292002720	Flagellar regulator YcgR; Region: YcgR; pfam07317
261292002721	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
261292002722	PilZ domain; Region: PilZ; pfam07238
261292002723	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
261292002724	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
261292002725	Flagellar protein FliT; Region: FliT; pfam05400
261292002726	Flagellar protein FliS; Region: FliS; cl00654
261292002727	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
261292002728	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
261292002729	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
261292002730	FlaG protein; Region: FlaG; pfam03646
261292002731	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
261292002732	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
261292002733	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
261292002734	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292002735	active site
261292002736	phosphorylation site [posttranslational modification]
261292002737	intermolecular recognition site; other site
261292002738	dimerization interface [polypeptide binding]; other site
261292002739	PAS domain S-box; Region: sensory_box; TIGR00229
261292002740	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292002741	putative active site [active]
261292002742	heme pocket [chemical binding]; other site
261292002743	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
261292002744	Histidine kinase; Region: HisKA_3; pfam07730
261292002745	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292002746	ATP binding site [chemical binding]; other site
261292002747	Mg2+ binding site [ion binding]; other site
261292002748	G-X-G motif; other site
261292002749	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
261292002750	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292002751	active site
261292002752	phosphorylation site [posttranslational modification]
261292002753	intermolecular recognition site; other site
261292002754	dimerization interface [polypeptide binding]; other site
261292002755	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
261292002756	DNA binding residues [nucleotide binding]
261292002757	dimerization interface [polypeptide binding]; other site
261292002758	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
261292002759	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
261292002760	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
261292002761	metal binding site [ion binding]; metal-binding site
261292002762	active site
261292002763	I-site; other site
261292002764	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
261292002765	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
261292002766	metal binding site [ion binding]; metal-binding site
261292002767	active site
261292002768	I-site; other site
261292002769	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
261292002770	EAL domain; Region: EAL; pfam00563
261292002771	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
261292002772	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292002773	active site
261292002774	phosphorylation site [posttranslational modification]
261292002775	intermolecular recognition site; other site
261292002776	dimerization interface [polypeptide binding]; other site
261292002777	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
261292002778	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
261292002779	putative binding surface; other site
261292002780	active site
261292002781	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
261292002782	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292002783	ATP binding site [chemical binding]; other site
261292002784	Mg2+ binding site [ion binding]; other site
261292002785	G-X-G motif; other site
261292002786	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
261292002787	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
261292002788	putative CheA interaction surface; other site
261292002789	CHASE3 domain; Region: CHASE3; cl05000
261292002790	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
261292002791	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
261292002792	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
261292002793	dimer interface [polypeptide binding]; other site
261292002794	putative CheW interface [polypeptide binding]; other site
261292002795	chemotaxis methyltransferase CheR; Provisional; Region: PRK10611
261292002796	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
261292002797	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
261292002798	chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13487
261292002799	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
261292002800	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292002801	active site
261292002802	phosphorylation site [posttranslational modification]
261292002803	intermolecular recognition site; other site
261292002804	dimerization interface [polypeptide binding]; other site
261292002805	CheB methylesterase; Region: CheB_methylest; pfam01339
261292002806	NlpC/P60 family; Region: NLPC_P60; pfam00877
261292002807	Domain of unknown function (DUF4389); Region: DUF4389; pfam14333
261292002808	Transposase; Region: HTH_Tnp_1; cl17663
261292002809	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
261292002810	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
261292002811	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
261292002812	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
261292002813	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
261292002814	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
261292002815	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
261292002816	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
261292002817	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
261292002818	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
261292002819	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
261292002820	Walker A motif; other site
261292002821	ATP binding site [chemical binding]; other site
261292002822	Walker B motif; other site
261292002823	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
261292002824	Membrane fusogenic activity; Region: BMFP; pfam04380
261292002825	Phosphotransferase enzyme family; Region: APH; pfam01636
261292002826	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
261292002827	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
261292002828	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
261292002829	Substrate binding site; other site
261292002830	metal-binding site
261292002831	proline aminopeptidase P II; Provisional; Region: PRK10879
261292002832	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
261292002833	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
261292002834	active site
261292002835	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
261292002836	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
261292002837	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
261292002838	Zn2+ binding site [ion binding]; other site
261292002839	Mg2+ binding site [ion binding]; other site
261292002840	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
261292002841	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
261292002842	ThiS interaction site; other site
261292002843	putative active site [active]
261292002844	tetramer interface [polypeptide binding]; other site
261292002845	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
261292002846	thiS-thiF/thiG interaction site; other site
261292002847	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
261292002848	Transposase; Region: DEDD_Tnp_IS110; pfam01548
261292002849	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
261292002850	Putative integral membrane protein DUF46; Region: DUF46; cl17511
261292002851	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
261292002852	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
261292002853	putative active site [active]
261292002854	putative metal binding site [ion binding]; other site
261292002855	Uncharacterized conserved protein [Function unknown]; Region: COG4279
261292002856	SWIM zinc finger; Region: SWIM; pfam04434
261292002857	SNF2 Helicase protein; Region: DUF3670; pfam12419
261292002858	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
261292002859	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
261292002860	ATP binding site [chemical binding]; other site
261292002861	putative Mg++ binding site [ion binding]; other site
261292002862	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
261292002863	nucleotide binding region [chemical binding]; other site
261292002864	ATP-binding site [chemical binding]; other site
261292002865	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
261292002866	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
261292002867	non-specific DNA binding site [nucleotide binding]; other site
261292002868	salt bridge; other site
261292002869	sequence-specific DNA binding site [nucleotide binding]; other site
261292002870	HipA N-terminal domain; Region: Couple_hipA; pfam13657
261292002871	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
261292002872	HipA-like N-terminal domain; Region: HipA_N; pfam07805
261292002873	HipA-like C-terminal domain; Region: HipA_C; pfam07804
261292002874	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
261292002875	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
261292002876	Coenzyme A binding pocket [chemical binding]; other site
261292002877	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
261292002878	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
261292002879	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
261292002880	Walker A/P-loop; other site
261292002881	ATP binding site [chemical binding]; other site
261292002882	Q-loop/lid; other site
261292002883	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
261292002884	ABC transporter signature motif; other site
261292002885	Walker B; other site
261292002886	D-loop; other site
261292002887	ABC transporter; Region: ABC_tran_2; pfam12848
261292002888	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
261292002889	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
261292002890	putative catalytic site [active]
261292002891	putative metal binding site [ion binding]; other site
261292002892	putative phosphate binding site [ion binding]; other site
261292002893	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
261292002894	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
261292002895	putative substrate translocation pore; other site
261292002896	Domain of unknown function (DUF4082); Region: DUF4082; pfam13313
261292002897	PEP-CTERM motif; Region: VPEP; pfam07589
261292002898	PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855
261292002899	putative active site [active]
261292002900	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
261292002901	S-adenosylmethionine binding site [chemical binding]; other site
261292002902	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
261292002903	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
261292002904	BRO family, N-terminal domain; Region: Bro-N; smart01040
261292002905	SEC-C motif; Region: SEC-C; pfam02810
261292002906	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
261292002907	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
261292002908	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
261292002909	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
261292002910	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
261292002911	Walker A/P-loop; other site
261292002912	ATP binding site [chemical binding]; other site
261292002913	Q-loop/lid; other site
261292002914	ABC transporter signature motif; other site
261292002915	Walker B; other site
261292002916	D-loop; other site
261292002917	H-loop/switch region; other site
261292002918	TOBE-like domain; Region: TOBE_3; pfam12857
261292002919	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
261292002920	dimer interface [polypeptide binding]; other site
261292002921	conserved gate region; other site
261292002922	putative PBP binding loops; other site
261292002923	ABC-ATPase subunit interface; other site
261292002924	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
261292002925	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
261292002926	dimer interface [polypeptide binding]; other site
261292002927	conserved gate region; other site
261292002928	putative PBP binding loops; other site
261292002929	ABC-ATPase subunit interface; other site
261292002930	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
261292002931	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811
261292002932	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
261292002933	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
261292002934	substrate binding pocket [chemical binding]; other site
261292002935	membrane-bound complex binding site; other site
261292002936	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
261292002937	Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055
261292002938	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
261292002939	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
261292002940	N-acetyl-D-glucosamine binding site [chemical binding]; other site
261292002941	catalytic residue [active]
261292002942	Protein of unknown function (DUF4255); Region: DUF4255; pfam14065
261292002943	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
261292002944	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
261292002945	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
261292002946	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
261292002947	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
261292002948	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
261292002949	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
261292002950	Phage protein D [General function prediction only]; Region: COG3500
261292002951	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
261292002952	Gene 25-like lysozyme; Region: GPW_gp25; pfam04965
261292002953	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
261292002954	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
261292002955	phage tail protein domain; Region: tail_TIGR02242
261292002956	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
261292002957	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
261292002958	Walker A motif; other site
261292002959	ATP binding site [chemical binding]; other site
261292002960	Walker B motif; other site
261292002961	arginine finger; other site
261292002962	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
261292002963	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
261292002964	catalytic residue [active]
261292002965	Transposase domain (DUF772); Region: DUF772; pfam05598
261292002966	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
261292002967	DDE superfamily endonuclease; Region: DDE_4; cl17710
261292002968	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
261292002969	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
261292002970	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
261292002971	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
261292002972	Walker A/P-loop; other site
261292002973	ATP binding site [chemical binding]; other site
261292002974	Q-loop/lid; other site
261292002975	ABC transporter signature motif; other site
261292002976	Walker B; other site
261292002977	D-loop; other site
261292002978	H-loop/switch region; other site
261292002979	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
261292002980	FtsX-like permease family; Region: FtsX; pfam02687
261292002981	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
261292002982	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
261292002983	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
261292002984	metal-binding site [ion binding]
261292002985	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
261292002986	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
261292002987	metal-binding site [ion binding]
261292002988	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
261292002989	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
261292002990	metal-binding site [ion binding]
261292002991	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
261292002992	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
261292002993	motif II; other site
261292002994	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
261292002995	sec-independent translocase; Provisional; Region: tatB; PRK00404
261292002996	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
261292002997	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
261292002998	twin arginine translocase protein A; Provisional; Region: tatA; PRK02958
261292002999	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
261292003000	nucleotide binding site/active site [active]
261292003001	HIT family signature motif; other site
261292003002	catalytic residue [active]
261292003003	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
261292003004	metal binding site [ion binding]; metal-binding site
261292003005	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
261292003006	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
261292003007	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
261292003008	substrate binding site [chemical binding]; other site
261292003009	glutamase interaction surface [polypeptide binding]; other site
261292003010	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
261292003011	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
261292003012	catalytic residues [active]
261292003013	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
261292003014	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
261292003015	putative active site [active]
261292003016	oxyanion strand; other site
261292003017	catalytic triad [active]
261292003018	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
261292003019	putative active site pocket [active]
261292003020	4-fold oligomerization interface [polypeptide binding]; other site
261292003021	metal binding residues [ion binding]; metal-binding site
261292003022	3-fold/trimer interface [polypeptide binding]; other site
261292003023	histidinol-phosphate aminotransferase; Provisional; Region: PRK04870
261292003024	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
261292003025	pyridoxal 5'-phosphate binding site [chemical binding]; other site
261292003026	homodimer interface [polypeptide binding]; other site
261292003027	catalytic residue [active]
261292003028	HDOD domain; Region: HDOD; pfam08668
261292003029	Uncharacterized conserved protein [Function unknown]; Region: COG1565
261292003030	pteridine reductase; Provisional; Region: PRK09135
261292003031	pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357
261292003032	NADP binding site [chemical binding]; other site
261292003033	substrate binding pocket [chemical binding]; other site
261292003034	active site
261292003035	putative transposase OrfB; Reviewed; Region: PHA02517
261292003036	HTH-like domain; Region: HTH_21; pfam13276
261292003037	Integrase core domain; Region: rve; pfam00665
261292003038	Integrase core domain; Region: rve_3; pfam13683
261292003039	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
261292003040	Transposase; Region: HTH_Tnp_1; pfam01527
261292003041	hypothetical protein; Reviewed; Region: PRK12497
261292003042	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
261292003043	putative ligand binding site [chemical binding]; other site
261292003044	Predicted methyltransferases [General function prediction only]; Region: COG0313
261292003045	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
261292003046	putative SAM binding site [chemical binding]; other site
261292003047	putative homodimer interface [polypeptide binding]; other site
261292003048	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
261292003049	active site
261292003050	substrate binding pocket [chemical binding]; other site
261292003051	dimer interface [polypeptide binding]; other site
261292003052	Protein of unknown function, DUF393; Region: DUF393; pfam04134
261292003053	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
261292003054	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
261292003055	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
261292003056	generic binding surface II; other site
261292003057	generic binding surface I; other site
261292003058	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
261292003059	VacJ like lipoprotein; Region: VacJ; cl01073
261292003060	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
261292003061	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
261292003062	Active site cavity [active]
261292003063	catalytic acid [active]
261292003064	hopanoid-associated phosphorylase; Region: HpnG; TIGR03468
261292003065	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
261292003066	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
261292003067	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
261292003068	Walker A/P-loop; other site
261292003069	ATP binding site [chemical binding]; other site
261292003070	Q-loop/lid; other site
261292003071	ABC transporter signature motif; other site
261292003072	Walker B; other site
261292003073	D-loop; other site
261292003074	H-loop/switch region; other site
261292003075	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
261292003076	active site
261292003077	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
261292003078	active site
261292003079	DDE superfamily endonuclease; Region: DDE_5; cl17874
261292003080	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
261292003081	Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693
261292003082	Ferredoxin [Energy production and conversion]; Region: COG1146
261292003083	4Fe-4S binding domain; Region: Fer4; cl02805
261292003084	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
261292003085	probable DNA repair protein; Region: TIGR03623
261292003086	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
261292003087	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
261292003088	Part of AAA domain; Region: AAA_19; pfam13245
261292003089	Family description; Region: UvrD_C_2; pfam13538
261292003090	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
261292003091	Ammonia monooxygenase/methane monooxygenase, subunit C; Region: AmoC; pfam04896
261292003092	methane monooxygenase/ammonia monooxygenase, subunit A; Region: CH4_NH3mon_ox_A; TIGR03080
261292003093	methane monooxygenase/ammonia monooxygenase, subunit B; Region: CH4_NH3mon_ox_B; TIGR03079
261292003094	Monooxygenase subunit B protein; Region: Monooxygenase_B; pfam04744
261292003095	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
261292003096	active site residue [active]
261292003097	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
261292003098	Protein kinase domain; Region: Pkinase; pfam00069
261292003099	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
261292003100	active site
261292003101	ATP binding site [chemical binding]; other site
261292003102	substrate binding site [chemical binding]; other site
261292003103	activation loop (A-loop); other site
261292003104	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
261292003105	active site
261292003106	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
261292003107	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292003108	active site
261292003109	phosphorylation site [posttranslational modification]
261292003110	intermolecular recognition site; other site
261292003111	dimerization interface [polypeptide binding]; other site
261292003112	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
261292003113	DNA binding site [nucleotide binding]
261292003114	Protein of unknown function (DUF3450); Region: DUF3450; pfam11932
261292003115	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
261292003116	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
261292003117	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
261292003118	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
261292003119	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
261292003120	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
261292003121	Tetratricopeptide repeat; Region: TPR_15; pfam13429
261292003122	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
261292003123	binding surface
261292003124	TPR motif; other site
261292003125	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
261292003126	binding surface
261292003127	TPR motif; other site
261292003128	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
261292003129	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
261292003130	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
261292003131	Protein of unknown function (DUF2845); Region: DUF2845; pfam11006
261292003132	PBP superfamily domain; Region: PBP_like_2; cl17296
261292003133	phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275
261292003134	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
261292003135	dimer interface [polypeptide binding]; other site
261292003136	conserved gate region; other site
261292003137	putative PBP binding loops; other site
261292003138	ABC-ATPase subunit interface; other site
261292003139	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
261292003140	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
261292003141	dimer interface [polypeptide binding]; other site
261292003142	conserved gate region; other site
261292003143	putative PBP binding loops; other site
261292003144	ABC-ATPase subunit interface; other site
261292003145	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
261292003146	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
261292003147	Walker A/P-loop; other site
261292003148	ATP binding site [chemical binding]; other site
261292003149	Q-loop/lid; other site
261292003150	ABC transporter signature motif; other site
261292003151	Walker B; other site
261292003152	D-loop; other site
261292003153	H-loop/switch region; other site
261292003154	Transposase; Region: HTH_Tnp_1; cl17663
261292003155	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
261292003156	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
261292003157	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676
261292003158	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
261292003159	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
261292003160	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
261292003161	CHAD domain; Region: CHAD; pfam05235
261292003162	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
261292003163	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
261292003164	P-loop; other site
261292003165	Magnesium ion binding site [ion binding]; other site
261292003166	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
261292003167	Magnesium ion binding site [ion binding]; other site
261292003168	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
261292003169	nudix motif; other site
261292003170	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
261292003171	pyruvate kinase; Provisional; Region: PRK14725
261292003172	active site
261292003173	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
261292003174	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
261292003175	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598
261292003176	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
261292003177	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
261292003178	metal binding site [ion binding]; metal-binding site
261292003179	active site
261292003180	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
261292003181	dimer interface [polypeptide binding]; other site
261292003182	substrate binding site [chemical binding]; other site
261292003183	metal binding sites [ion binding]; metal-binding site
261292003184	arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291
261292003185	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
261292003186	P loop; other site
261292003187	Nucleotide binding site [chemical binding]; other site
261292003188	DTAP/Switch II; other site
261292003189	Switch I; other site
261292003190	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
261292003191	P loop; other site
261292003192	Nucleotide binding site [chemical binding]; other site
261292003193	DTAP/Switch II; other site
261292003194	Switch I; other site
261292003195	Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953
261292003196	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
261292003197	dimerization interface [polypeptide binding]; other site
261292003198	putative DNA binding site [nucleotide binding]; other site
261292003199	putative Zn2+ binding site [ion binding]; other site
261292003200	Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027
261292003201	putative transposase OrfB; Reviewed; Region: PHA02517
261292003202	HTH-like domain; Region: HTH_21; pfam13276
261292003203	Integrase core domain; Region: rve; pfam00665
261292003204	Integrase core domain; Region: rve_3; cl15866
261292003205	Transposase; Region: HTH_Tnp_1; pfam01527
261292003206	AAA domain; Region: AAA_32; pfam13654
261292003207	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
261292003208	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
261292003209	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
261292003210	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
261292003211	Multicopper oxidase; Region: Cu-oxidase; pfam00394
261292003212	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
261292003213	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
261292003214	HlyD family secretion protein; Region: HlyD_3; pfam13437
261292003215	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
261292003216	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
261292003217	bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021
261292003218	ADP binding site [chemical binding]; other site
261292003219	magnesium binding site [ion binding]; other site
261292003220	putative shikimate binding site; other site
261292003221	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
261292003222	active site
261292003223	dimer interface [polypeptide binding]; other site
261292003224	metal binding site [ion binding]; metal-binding site
261292003225	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
261292003226	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
261292003227	Zn2+ binding site [ion binding]; other site
261292003228	Mg2+ binding site [ion binding]; other site
261292003229	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
261292003230	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
261292003231	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
261292003232	substrate binding site [chemical binding]; other site
261292003233	active site
261292003234	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
261292003235	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292003236	active site
261292003237	phosphorylation site [posttranslational modification]
261292003238	intermolecular recognition site; other site
261292003239	dimerization interface [polypeptide binding]; other site
261292003240	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
261292003241	DNA binding site [nucleotide binding]
261292003242	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
261292003243	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
261292003244	dimer interface [polypeptide binding]; other site
261292003245	phosphorylation site [posttranslational modification]
261292003246	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292003247	ATP binding site [chemical binding]; other site
261292003248	Mg2+ binding site [ion binding]; other site
261292003249	G-X-G motif; other site
261292003250	Domain of unknown function (DUF897); Region: DUF897; pfam05982
261292003251	Nitrogen regulatory protein P-II; Region: P-II; cl00412
261292003252	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
261292003253	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
261292003254	putative acyl-acceptor binding pocket; other site
261292003255	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
261292003256	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
261292003257	active site
261292003258	metal binding site [ion binding]; metal-binding site
261292003259	dihydrodipicolinate reductase; Provisional; Region: PRK00048
261292003260	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
261292003261	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
261292003262	outer membrane biogenesis protein BamE; Provisional; Region: PRK11548
261292003263	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
261292003264	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
261292003265	ferric uptake regulator; Provisional; Region: fur; PRK09462
261292003266	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
261292003267	metal binding site 2 [ion binding]; metal-binding site
261292003268	putative DNA binding helix; other site
261292003269	metal binding site 1 [ion binding]; metal-binding site
261292003270	dimer interface [polypeptide binding]; other site
261292003271	structural Zn2+ binding site [ion binding]; other site
261292003272	Transglycosylase SLT domain; Region: SLT_2; pfam13406
261292003273	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
261292003274	N-acetyl-D-glucosamine binding site [chemical binding]; other site
261292003275	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
261292003276	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
261292003277	malate dehydrogenase; Provisional; Region: PRK05442
261292003278	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
261292003279	NAD(P) binding site [chemical binding]; other site
261292003280	dimer interface [polypeptide binding]; other site
261292003281	malate binding site [chemical binding]; other site
261292003282	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
261292003283	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
261292003284	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
261292003285	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
261292003286	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
261292003287	motif II; other site
261292003288	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
261292003289	Predicted ATPase [General function prediction only]; Region: COG1485
261292003290	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
261292003291	Walker A/P-loop; other site
261292003292	ATP binding site [chemical binding]; other site
261292003293	Q-loop/lid; other site
261292003294	ABC transporter signature motif; other site
261292003295	Walker B; other site
261292003296	D-loop; other site
261292003297	H-loop/switch region; other site
261292003298	AmpG-like permease; Region: 2A0125; TIGR00901
261292003299	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
261292003300	putative active site [active]
261292003301	putative catalytic site [active]
261292003302	putative DNA binding site [nucleotide binding]; other site
261292003303	putative phosphate binding site [ion binding]; other site
261292003304	metal binding site A [ion binding]; metal-binding site
261292003305	putative AP binding site [nucleotide binding]; other site
261292003306	putative metal binding site B [ion binding]; other site
261292003307	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
261292003308	active site
261292003309	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
261292003310	Peptidase M15; Region: Peptidase_M15_3; cl01194
261292003311	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
261292003312	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
261292003313	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
261292003314	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
261292003315	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
261292003316	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
261292003317	active site
261292003318	metal binding site [ion binding]; metal-binding site
261292003319	Transposase domain (DUF772); Region: DUF772; pfam05598
261292003320	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
261292003321	flagellin; Validated; Region: PRK08026
261292003322	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
261292003323	Sel1-like repeats; Region: SEL1; smart00671
261292003324	Sel1 repeat; Region: Sel1; cl02723
261292003325	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
261292003326	Phage Tail Collar Domain; Region: Collar; pfam07484
261292003327	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
261292003328	G1 box; other site
261292003329	GTP/Mg2+ binding site [chemical binding]; other site
261292003330	G2 box; other site
261292003331	Switch I region; other site
261292003332	G3 box; other site
261292003333	Switch II region; other site
261292003334	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
261292003335	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
261292003336	G1 box; other site
261292003337	GTP/Mg2+ binding site [chemical binding]; other site
261292003338	G2 box; other site
261292003339	Switch I region; other site
261292003340	G3 box; other site
261292003341	Switch II region; other site
261292003342	G4 box; other site
261292003343	G5 box; other site
261292003344	Protein of unknown function (DUF3750); Region: DUF3750; pfam12570
261292003345	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
261292003346	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
261292003347	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
261292003348	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
261292003349	dimer interface [polypeptide binding]; other site
261292003350	conserved gate region; other site
261292003351	putative PBP binding loops; other site
261292003352	ABC-ATPase subunit interface; other site
261292003353	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
261292003354	dimer interface [polypeptide binding]; other site
261292003355	conserved gate region; other site
261292003356	putative PBP binding loops; other site
261292003357	ABC-ATPase subunit interface; other site
261292003358	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
261292003359	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
261292003360	Walker A/P-loop; other site
261292003361	ATP binding site [chemical binding]; other site
261292003362	Q-loop/lid; other site
261292003363	ABC transporter signature motif; other site
261292003364	Walker B; other site
261292003365	D-loop; other site
261292003366	H-loop/switch region; other site
261292003367	TOBE domain; Region: TOBE_2; pfam08402
261292003368	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
261292003369	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
261292003370	catalytic residues [active]
261292003371	transcription termination factor Rho; Provisional; Region: rho; PRK09376
261292003372	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
261292003373	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
261292003374	RNA binding site [nucleotide binding]; other site
261292003375	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
261292003376	multimer interface [polypeptide binding]; other site
261292003377	Walker A motif; other site
261292003378	ATP binding site [chemical binding]; other site
261292003379	Walker B motif; other site
261292003380	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
261292003381	Cupin domain; Region: Cupin_2; pfam07883
261292003382	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
261292003383	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
261292003384	putative NAD(P) binding site [chemical binding]; other site
261292003385	putative substrate binding site [chemical binding]; other site
261292003386	catalytic Zn binding site [ion binding]; other site
261292003387	structural Zn binding site [ion binding]; other site
261292003388	dimer interface [polypeptide binding]; other site
261292003389	putative transposase OrfB; Reviewed; Region: PHA02517
261292003390	HTH-like domain; Region: HTH_21; pfam13276
261292003391	Integrase core domain; Region: rve; pfam00665
261292003392	Integrase core domain; Region: rve_3; cl15866
261292003393	Transposase; Region: HTH_Tnp_1; pfam01527
261292003394	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
261292003395	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
261292003396	SLBB domain; Region: SLBB; pfam10531
261292003397	chain length determinant protein EpsF; Region: EpsF; TIGR03017
261292003398	Chain length determinant protein; Region: Wzz; cl15801
261292003399	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
261292003400	Chain length determinant protein; Region: Wzz; cl15801
261292003401	chain length determinant protein tyrosine kinase EpsG; Region: EpsG; TIGR03029
261292003402	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
261292003403	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
261292003404	Protein of unknown function (DUF3485); Region: DUF3485; pfam11984
261292003405	Methyltransferase domain; Region: Methyltransf_23; pfam13489
261292003406	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
261292003407	S-adenosylmethionine binding site [chemical binding]; other site
261292003408	Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387
261292003409	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
261292003410	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
261292003411	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
261292003412	putative active site [active]
261292003413	putative metal binding site [ion binding]; other site
261292003414	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
261292003415	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
261292003416	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
261292003417	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
261292003418	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
261292003419	Transposase domain (DUF772); Region: DUF772; pfam05598
261292003420	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
261292003421	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
261292003422	Transposase; Region: HTH_Tnp_1; cl17663
261292003423	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
261292003424	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
261292003425	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
261292003426	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
261292003427	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
261292003428	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
261292003429	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
261292003430	Winged helix-turn helix; Region: HTH_29; pfam13551
261292003431	Winged helix-turn helix; Region: HTH_33; pfam13592
261292003432	DDE superfamily endonuclease; Region: DDE_3; pfam13358
261292003433	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
261292003434	Transposase IS200 like; Region: Y1_Tnp; pfam01797
261292003435	Transposase; Region: HTH_Tnp_1; pfam01527
261292003436	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
261292003437	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
261292003438	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
261292003439	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
261292003440	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
261292003441	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
261292003442	Family description; Region: VCBS; pfam13517
261292003443	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
261292003444	Cadherin repeat-like domain; Region: CA_like; cl15786
261292003445	Ca2+ binding site [ion binding]; other site
261292003446	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
261292003447	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
261292003448	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
261292003449	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
261292003450	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
261292003451	lipoyl attachment site [posttranslational modification]; other site
261292003452	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
261292003453	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
261292003454	tetramer interface [polypeptide binding]; other site
261292003455	pyridoxal 5'-phosphate binding site [chemical binding]; other site
261292003456	catalytic residue [active]
261292003457	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
261292003458	dimer interface [polypeptide binding]; other site
261292003459	catalytic triad [active]
261292003460	peroxidatic and resolving cysteines [active]
261292003461	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
261292003462	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
261292003463	tetramer interface [polypeptide binding]; other site
261292003464	pyridoxal 5'-phosphate binding site [chemical binding]; other site
261292003465	catalytic residue [active]
261292003466	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
261292003467	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
261292003468	substrate binding site [chemical binding]; other site
261292003469	ATP binding site [chemical binding]; other site
261292003470	Mannitol repressor; Region: MtlR; cl11450
261292003471	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
261292003472	putative catalytic site [active]
261292003473	putative metal binding site [ion binding]; other site
261292003474	putative phosphate binding site [ion binding]; other site
261292003475	Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436
261292003476	Ammonia monooxygenase/methane monooxygenase, subunit C; Region: AmoC; pfam04896
261292003477	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
261292003478	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292003479	active site
261292003480	phosphorylation site [posttranslational modification]
261292003481	intermolecular recognition site; other site
261292003482	dimerization interface [polypeptide binding]; other site
261292003483	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
261292003484	DNA binding residues [nucleotide binding]
261292003485	dimerization interface [polypeptide binding]; other site
261292003486	PAS domain; Region: PAS_9; pfam13426
261292003487	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
261292003488	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
261292003489	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292003490	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
261292003491	putative active site [active]
261292003492	heme pocket [chemical binding]; other site
261292003493	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
261292003494	dimer interface [polypeptide binding]; other site
261292003495	phosphorylation site [posttranslational modification]
261292003496	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292003497	ATP binding site [chemical binding]; other site
261292003498	Mg2+ binding site [ion binding]; other site
261292003499	G-X-G motif; other site
261292003500	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292003501	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
261292003502	putative active site [active]
261292003503	heme pocket [chemical binding]; other site
261292003504	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292003505	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
261292003506	putative active site [active]
261292003507	heme pocket [chemical binding]; other site
261292003508	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292003509	putative active site [active]
261292003510	heme pocket [chemical binding]; other site
261292003511	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
261292003512	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
261292003513	dimer interface [polypeptide binding]; other site
261292003514	phosphorylation site [posttranslational modification]
261292003515	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292003516	ATP binding site [chemical binding]; other site
261292003517	Mg2+ binding site [ion binding]; other site
261292003518	G-X-G motif; other site
261292003519	Response regulator receiver domain; Region: Response_reg; pfam00072
261292003520	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292003521	active site
261292003522	phosphorylation site [posttranslational modification]
261292003523	intermolecular recognition site; other site
261292003524	dimerization interface [polypeptide binding]; other site
261292003525	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
261292003526	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292003527	active site
261292003528	phosphorylation site [posttranslational modification]
261292003529	intermolecular recognition site; other site
261292003530	dimerization interface [polypeptide binding]; other site
261292003531	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
261292003532	DNA binding residues [nucleotide binding]
261292003533	dimerization interface [polypeptide binding]; other site
261292003534	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
261292003535	PAS domain; Region: PAS_9; pfam13426
261292003536	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292003537	putative active site [active]
261292003538	heme pocket [chemical binding]; other site
261292003539	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292003540	PAS fold; Region: PAS_3; pfam08447
261292003541	putative active site [active]
261292003542	heme pocket [chemical binding]; other site
261292003543	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
261292003544	dimer interface [polypeptide binding]; other site
261292003545	phosphorylation site [posttranslational modification]
261292003546	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292003547	ATP binding site [chemical binding]; other site
261292003548	G-X-G motif; other site
261292003549	Transposase domain (DUF772); Region: DUF772; pfam05598
261292003550	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
261292003551	DDE superfamily endonuclease; Region: DDE_4; cl17710
261292003552	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
261292003553	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
261292003554	non-specific DNA interactions [nucleotide binding]; other site
261292003555	DNA binding site [nucleotide binding]
261292003556	sequence specific DNA binding site [nucleotide binding]; other site
261292003557	putative cAMP binding site [chemical binding]; other site
261292003558	putative transposase OrfB; Reviewed; Region: PHA02517
261292003559	HTH-like domain; Region: HTH_21; pfam13276
261292003560	Integrase core domain; Region: rve; pfam00665
261292003561	Integrase core domain; Region: rve_3; cl15866
261292003562	Transposase; Region: HTH_Tnp_1; pfam01527
261292003563	Putative motility protein; Region: YjfB_motility; pfam14070
261292003564	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
261292003565	active site
261292003566	NTP binding site [chemical binding]; other site
261292003567	metal binding triad [ion binding]; metal-binding site
261292003568	antibiotic binding site [chemical binding]; other site
261292003569	Protein of unknown function DUF86; Region: DUF86; pfam01934
261292003570	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
261292003571	metal ion-dependent adhesion site (MIDAS); other site
261292003572	MoxR-like ATPases [General function prediction only]; Region: COG0714
261292003573	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
261292003574	Walker A motif; other site
261292003575	ATP binding site [chemical binding]; other site
261292003576	Walker B motif; other site
261292003577	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
261292003578	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
261292003579	multimerization interface [polypeptide binding]; other site
261292003580	ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208
261292003581	Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232
261292003582	dimer interface [polypeptide binding]; other site
261292003583	catalytic residue [active]
261292003584	metal binding site [ion binding]; metal-binding site
261292003585	Transcriptional regulator [Transcription]; Region: LysR; COG0583
261292003586	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
261292003587	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
261292003588	putative dimerization interface [polypeptide binding]; other site
261292003589	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
261292003590	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
261292003591	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
261292003592	FeS/SAM binding site; other site
261292003593	PEP-CTERM motif; Region: VPEP; pfam07589
261292003594	Transposase domain (DUF772); Region: DUF772; pfam05598
261292003595	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
261292003596	DDE superfamily endonuclease; Region: DDE_4; cl17710
261292003597	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
261292003598	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
261292003599	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
261292003600	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
261292003601	S-adenosylmethionine binding site [chemical binding]; other site
261292003602	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
261292003603	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
261292003604	Walker A/P-loop; other site
261292003605	ATP binding site [chemical binding]; other site
261292003606	Q-loop/lid; other site
261292003607	ABC transporter signature motif; other site
261292003608	Walker B; other site
261292003609	D-loop; other site
261292003610	H-loop/switch region; other site
261292003611	CcmB protein; Region: CcmB; pfam03379
261292003612	heme exporter protein CcmC; Region: ccmC; TIGR01191
261292003613	heme exporter protein CcmD; Region: cytochro_ccmD; TIGR03141
261292003614	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
261292003615	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
261292003616	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
261292003617	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
261292003618	catalytic residues [active]
261292003619	central insert; other site
261292003620	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
261292003621	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
261292003622	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
261292003623	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
261292003624	binding surface
261292003625	TPR motif; other site
261292003626	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
261292003627	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
261292003628	catalytic triad [active]
261292003629	Transposase; Region: HTH_Tnp_1; pfam01527
261292003630	Winged helix-turn helix; Region: HTH_29; pfam13551
261292003631	Winged helix-turn helix; Region: HTH_33; pfam13592
261292003632	DDE superfamily endonuclease; Region: DDE_3; pfam13358
261292003633	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
261292003634	Winged helix-turn helix; Region: HTH_29; pfam13551
261292003635	Winged helix-turn helix; Region: HTH_33; pfam13592
261292003636	DDE superfamily endonuclease; Region: DDE_3; pfam13358
261292003637	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
261292003638	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292003639	active site
261292003640	phosphorylation site [posttranslational modification]
261292003641	intermolecular recognition site; other site
261292003642	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
261292003643	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292003644	active site
261292003645	phosphorylation site [posttranslational modification]
261292003646	intermolecular recognition site; other site
261292003647	dimerization interface [polypeptide binding]; other site
261292003648	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
261292003649	DNA binding residues [nucleotide binding]
261292003650	dimerization interface [polypeptide binding]; other site
261292003651	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
261292003652	G1 box; other site
261292003653	GTP/Mg2+ binding site [chemical binding]; other site
261292003654	G2 box; other site
261292003655	Switch I region; other site
261292003656	G3 box; other site
261292003657	Switch II region; other site
261292003658	G4 box; other site
261292003659	Uncharacterized conserved protein [Function unknown]; Region: COG2928
261292003660	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
261292003661	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
261292003662	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
261292003663	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292003664	PAS domain; Region: PAS_9; pfam13426
261292003665	putative active site [active]
261292003666	heme pocket [chemical binding]; other site
261292003667	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
261292003668	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
261292003669	metal binding site [ion binding]; metal-binding site
261292003670	active site
261292003671	I-site; other site
261292003672	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
261292003673	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
261292003674	PEP-CTERM motif; Region: VPEP; pfam07589
261292003675	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
261292003676	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
261292003677	active site
261292003678	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
261292003679	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
261292003680	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
261292003681	dinuclear metal binding motif [ion binding]; other site
261292003682	putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073
261292003683	Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436
261292003684	phosphoribulokinase; Provisional; Region: PRK15453
261292003685	active site
261292003686	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
261292003687	Part of AAA domain; Region: AAA_19; pfam13245
261292003688	Family description; Region: UvrD_C_2; pfam13538
261292003689	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
261292003690	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_5; cd11352
261292003691	active site
261292003692	catalytic site [active]
261292003693	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cl00208
261292003694	CAS motifs; other site
261292003695	active site
261292003696	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
261292003697	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619
261292003698	active site
261292003699	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
261292003700	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
261292003701	putative active site [active]
261292003702	putative substrate binding site [chemical binding]; other site
261292003703	ATP binding site [chemical binding]; other site
261292003704	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
261292003705	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
261292003706	DNA polymerase I; Provisional; Region: PRK05755
261292003707	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
261292003708	active site
261292003709	metal binding site 1 [ion binding]; metal-binding site
261292003710	putative 5' ssDNA interaction site; other site
261292003711	metal binding site 3; metal-binding site
261292003712	metal binding site 2 [ion binding]; metal-binding site
261292003713	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
261292003714	putative DNA binding site [nucleotide binding]; other site
261292003715	putative metal binding site [ion binding]; other site
261292003716	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
261292003717	active site
261292003718	catalytic site [active]
261292003719	substrate binding site [chemical binding]; other site
261292003720	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
261292003721	active site
261292003722	DNA binding site [nucleotide binding]
261292003723	catalytic site [active]
261292003724	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
261292003725	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
261292003726	homodimer interface [polypeptide binding]; other site
261292003727	oligonucleotide binding site [chemical binding]; other site
261292003728	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
261292003729	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
261292003730	RNA binding surface [nucleotide binding]; other site
261292003731	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
261292003732	active site
261292003733	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
261292003734	active site
261292003735	catalytic triad [active]
261292003736	oxyanion hole [active]
261292003737	switch loop; other site
261292003738	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
261292003739	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
261292003740	Walker A/P-loop; other site
261292003741	ATP binding site [chemical binding]; other site
261292003742	Q-loop/lid; other site
261292003743	ABC transporter signature motif; other site
261292003744	Walker B; other site
261292003745	D-loop; other site
261292003746	H-loop/switch region; other site
261292003747	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
261292003748	FtsX-like permease family; Region: FtsX; pfam02687
261292003749	coproporphyrinogen III oxidase; Provisional; Region: PRK08898
261292003750	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
261292003751	FeS/SAM binding site; other site
261292003752	HemN C-terminal domain; Region: HemN_C; pfam06969
261292003753	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
261292003754	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292003755	ATP binding site [chemical binding]; other site
261292003756	Mg2+ binding site [ion binding]; other site
261292003757	G-X-G motif; other site
261292003758	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
261292003759	UreE urease accessory protein, C-terminal domain; Region: UreE_C; smart00987
261292003760	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
261292003761	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
261292003762	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
261292003763	active site
261292003764	Protein of unknown function (DUF3465); Region: DUF3465; pfam11948
261292003765	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
261292003766	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
261292003767	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
261292003768	Protein of unknown function (DUF3015); Region: DUF3015; pfam11220
261292003769	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
261292003770	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
261292003771	nucleophilic elbow; other site
261292003772	catalytic triad; other site
261292003773	TAP-like protein; Region: Abhydrolase_4; pfam08386
261292003774	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
261292003775	Zn2+ binding site [ion binding]; other site
261292003776	Mg2+ binding site [ion binding]; other site
261292003777	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
261292003778	Zn2+ binding site [ion binding]; other site
261292003779	Mg2+ binding site [ion binding]; other site
261292003780	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
261292003781	Transposase [DNA replication, recombination, and repair]; Region: COG5433
261292003782	Transposase [DNA replication, recombination, and repair]; Region: COG5433
261292003783	Transposase; Region: HTH_Tnp_1; pfam01527
261292003784	putative transposase OrfB; Reviewed; Region: PHA02517
261292003785	HTH-like domain; Region: HTH_21; pfam13276
261292003786	Integrase core domain; Region: rve; pfam00665
261292003787	Integrase core domain; Region: rve_3; cl15866
261292003788	aconitate hydratase; Region: PLN00070
261292003789	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
261292003790	substrate binding site [chemical binding]; other site
261292003791	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
261292003792	ligand binding site [chemical binding]; other site
261292003793	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
261292003794	substrate binding site [chemical binding]; other site
261292003795	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
261292003796	S-adenosylmethionine binding site [chemical binding]; other site
261292003797	Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941
261292003798	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
261292003799	catalytic loop [active]
261292003800	iron binding site [ion binding]; other site
261292003801	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
261292003802	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
261292003803	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
261292003804	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
261292003805	SLBB domain; Region: SLBB; pfam10531
261292003806	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
261292003807	Protein of unknown function (DUF1614); Region: DUF1614; pfam07758
261292003808	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
261292003809	AAA domain; Region: AAA_33; pfam13671
261292003810	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
261292003811	Zn binding site [ion binding]; other site
261292003812	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
261292003813	M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663
261292003814	Peptidase family M28; Region: Peptidase_M28; pfam04389
261292003815	metal binding site [ion binding]; metal-binding site
261292003816	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
261292003817	Helix-turn-helix domain; Region: HTH_28; pfam13518
261292003818	Winged helix-turn helix; Region: HTH_29; pfam13551
261292003819	Winged helix-turn helix; Region: HTH_33; pfam13592
261292003820	DDE superfamily endonuclease; Region: DDE_3; pfam13358
261292003821	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
261292003822	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
261292003823	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
261292003824	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
261292003825	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
261292003826	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
261292003827	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
261292003828	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
261292003829	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
261292003830	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
261292003831	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
261292003832	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
261292003833	active site
261292003834	GMP synthase; Reviewed; Region: guaA; PRK00074
261292003835	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
261292003836	AMP/PPi binding site [chemical binding]; other site
261292003837	candidate oxyanion hole; other site
261292003838	catalytic triad [active]
261292003839	potential glutamine specificity residues [chemical binding]; other site
261292003840	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
261292003841	ATP Binding subdomain [chemical binding]; other site
261292003842	Ligand Binding sites [chemical binding]; other site
261292003843	Dimerization subdomain; other site
261292003844	integrase; Provisional; Region: PRK09692
261292003845	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
261292003846	active site
261292003847	Int/Topo IB signature motif; other site
261292003848	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930
261292003849	Restriction alleviation protein Lar; Region: Lar_restr_allev; cl08047
261292003850	Domain of unknown function (DUF4326); Region: DUF4326; pfam14216
261292003851	Pleckstrin homology-like domain; Region: PH-like; cl17171
261292003852	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
261292003853	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
261292003854	dimer interface [polypeptide binding]; other site
261292003855	ssDNA binding site [nucleotide binding]; other site
261292003856	tetramer (dimer of dimers) interface [polypeptide binding]; other site
261292003857	DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684
261292003858	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
261292003859	Zn binding sites [ion binding]; other site
261292003860	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
261292003861	Walker A/P-loop; other site
261292003862	ATP binding site [chemical binding]; other site
261292003863	Putative exonuclease, RdgC; Region: RdgC; cl01122
261292003864	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
261292003865	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
261292003866	PEP-CTERM motif; Region: VPEP; pfam07589
261292003867	Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197
261292003868	Protein of unknown function (DUF1019); Region: DUF1019; pfam06254
261292003869	Transcriptional regulator; Region: Rrf2; cl17282
261292003870	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
261292003871	DNA methylase; Region: N6_N4_Mtase; pfam01555
261292003872	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713
261292003873	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
261292003874	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
261292003875	non-specific DNA binding site [nucleotide binding]; other site
261292003876	salt bridge; other site
261292003877	sequence-specific DNA binding site [nucleotide binding]; other site
261292003878	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
261292003879	trimer interface [polypeptide binding]; other site
261292003880	Phage protein Gp37/Gp68; Region: Gp37_Gp68; pfam07505
261292003881	Mor transcription activator family; Region: Mor; cl02360
261292003882	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
261292003883	N-acetyl-D-glucosamine binding site [chemical binding]; other site
261292003884	catalytic residue [active]
261292003885	internal virion protein C; Region: PHA00431
261292003886	Peptidase M15; Region: Peptidase_M15_3; cl01194
261292003887	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
261292003888	Catalytic site; other site
261292003889	Staphylococcal nuclease homologue; Region: SNase; pfam00565
261292003890	Protein of unknown function (DUF2958); Region: DUF2958; pfam11171
261292003891	Domain of unknown function (DUF4393); Region: DUF4393; pfam14337
261292003892	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
261292003893	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
261292003894	YcfA-like protein; Region: YcfA; pfam07927
261292003895	Methyltransferase domain; Region: Methyltransf_26; pfam13659
261292003896	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
261292003897	helicase superfamily c-terminal domain; Region: HELICc; smart00490
261292003898	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
261292003899	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
261292003900	active site
261292003901	catalytic residues [active]
261292003902	DNA binding site [nucleotide binding]
261292003903	Int/Topo IB signature motif; other site
261292003904	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
261292003905	CrcB-like protein; Region: CRCB; cl09114
261292003906	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
261292003907	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
261292003908	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741
261292003909	nucleophilic elbow; other site
261292003910	catalytic triad; other site
261292003911	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
261292003912	multiple promoter invertase; Provisional; Region: mpi; PRK13413
261292003913	catalytic residues [active]
261292003914	catalytic nucleophile [active]
261292003915	Presynaptic Site I dimer interface [polypeptide binding]; other site
261292003916	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
261292003917	Synaptic Flat tetramer interface [polypeptide binding]; other site
261292003918	Synaptic Site I dimer interface [polypeptide binding]; other site
261292003919	DNA binding site [nucleotide binding]
261292003920	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
261292003921	DNA-binding interface [nucleotide binding]; DNA binding site
261292003922	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
261292003923	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
261292003924	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781
261292003925	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
261292003926	DNA binding residues [nucleotide binding]
261292003927	putative dimer interface [polypeptide binding]; other site
261292003928	putative metal binding residues [ion binding]; other site
261292003929	thiopurine S-methyltransferase, Se/Te detoxification family; Region: TMPT_Se_Te; TIGR03840
261292003930	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
261292003931	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
261292003932	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
261292003933	HflX GTPase family; Region: HflX; cd01878
261292003934	G1 box; other site
261292003935	GTP/Mg2+ binding site [chemical binding]; other site
261292003936	Switch I region; other site
261292003937	G2 box; other site
261292003938	G3 box; other site
261292003939	Switch II region; other site
261292003940	G4 box; other site
261292003941	G5 box; other site
261292003942	chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777
261292003943	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
261292003944	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
261292003945	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
261292003946	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
261292003947	N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814
261292003948	active site
261292003949	metal binding site [ion binding]; metal-binding site
261292003950	homodimer interface [polypeptide binding]; other site
261292003951	catalytic site [active]
261292003952	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
261292003953	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
261292003954	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
261292003955	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
261292003956	putative ADP-binding pocket [chemical binding]; other site
261292003957	choice-of-anchor C domain; Region: choice_anch_C; TIGR04362
261292003958	PilZ domain; Region: PilZ; pfam07238
261292003959	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
261292003960	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292003961	active site
261292003962	phosphorylation site [posttranslational modification]
261292003963	intermolecular recognition site; other site
261292003964	dimerization interface [polypeptide binding]; other site
261292003965	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
261292003966	DNA binding residues [nucleotide binding]
261292003967	dimerization interface [polypeptide binding]; other site
261292003968	Predicted permeases [General function prediction only]; Region: COG0795
261292003969	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
261292003970	MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804
261292003971	active site
261292003972	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
261292003973	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
261292003974	putative ADP-binding pocket [chemical binding]; other site
261292003975	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
261292003976	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
261292003977	putative ADP-binding pocket [chemical binding]; other site
261292003978	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
261292003979	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
261292003980	Walker A/P-loop; other site
261292003981	ATP binding site [chemical binding]; other site
261292003982	Q-loop/lid; other site
261292003983	ABC transporter signature motif; other site
261292003984	Walker B; other site
261292003985	D-loop; other site
261292003986	H-loop/switch region; other site
261292003987	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
261292003988	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
261292003989	putative NAD(P) binding site [chemical binding]; other site
261292003990	active site
261292003991	putative substrate binding site [chemical binding]; other site
261292003992	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
261292003993	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
261292003994	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
261292003995	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
261292003996	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
261292003997	nucleotide binding site [chemical binding]; other site
261292003998	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953
261292003999	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
261292004000	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
261292004001	putative dimer interface [polypeptide binding]; other site
261292004002	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
261292004003	oligomerisation interface [polypeptide binding]; other site
261292004004	mobile loop; other site
261292004005	roof hairpin; other site
261292004006	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
261292004007	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
261292004008	ring oligomerisation interface [polypeptide binding]; other site
261292004009	ATP/Mg binding site [chemical binding]; other site
261292004010	stacking interactions; other site
261292004011	hinge regions; other site
261292004012	Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436
261292004013	Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; cl01562
261292004014	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
261292004015	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
261292004016	active site
261292004017	metal binding site [ion binding]; metal-binding site
261292004018	Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743
261292004019	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
261292004020	PGAP1-like protein; Region: PGAP1; pfam07819
261292004021	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
261292004022	Predicted flavoprotein [General function prediction only]; Region: COG0431
261292004023	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
261292004024	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
261292004025	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
261292004026	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292004027	ATP binding site [chemical binding]; other site
261292004028	Mg2+ binding site [ion binding]; other site
261292004029	G-X-G motif; other site
261292004030	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
261292004031	anchoring element; other site
261292004032	dimer interface [polypeptide binding]; other site
261292004033	ATP binding site [chemical binding]; other site
261292004034	TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030
261292004035	active site
261292004036	putative metal-binding site [ion binding]; other site
261292004037	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
261292004038	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
261292004039	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
261292004040	CAP-like domain; other site
261292004041	active site
261292004042	primary dimer interface [polypeptide binding]; other site
261292004043	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
261292004044	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
261292004045	putative NADP binding site [chemical binding]; other site
261292004046	putative substrate binding site [chemical binding]; other site
261292004047	active site
261292004048	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
261292004049	active site lid residues [active]
261292004050	substrate binding pocket [chemical binding]; other site
261292004051	catalytic residues [active]
261292004052	substrate-Mg2+ binding site; other site
261292004053	aspartate-rich region 1; other site
261292004054	aspartate-rich region 2; other site
261292004055	diaminopimelate decarboxylase; Region: lysA; TIGR01048
261292004056	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
261292004057	active site
261292004058	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
261292004059	substrate binding site [chemical binding]; other site
261292004060	catalytic residues [active]
261292004061	dimer interface [polypeptide binding]; other site
261292004062	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361
261292004063	Protein of unknown function (DUF330); Region: DUF330; cl01135
261292004064	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
261292004065	mce related protein; Region: MCE; pfam02470
261292004066	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
261292004067	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
261292004068	Walker A/P-loop; other site
261292004069	ATP binding site [chemical binding]; other site
261292004070	Q-loop/lid; other site
261292004071	ABC transporter signature motif; other site
261292004072	Walker B; other site
261292004073	D-loop; other site
261292004074	H-loop/switch region; other site
261292004075	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
261292004076	Permease; Region: Permease; pfam02405
261292004077	AMIN domain; Region: AMIN; pfam11741
261292004078	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
261292004079	active site
261292004080	metal binding site [ion binding]; metal-binding site
261292004081	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
261292004082	epoxyqueuosine reductase; Region: TIGR00276
261292004083	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
261292004084	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
261292004085	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
261292004086	ATP-grasp domain; Region: ATP-grasp; pfam02222
261292004087	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
261292004088	active site
261292004089	phosphate binding residues; other site
261292004090	catalytic residues [active]
261292004091	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
261292004092	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
261292004093	transmembrane helices; other site
261292004094	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
261292004095	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
261292004096	amidase catalytic site [active]
261292004097	Zn binding residues [ion binding]; other site
261292004098	substrate binding site [chemical binding]; other site
261292004099	thymidylate kinase; Validated; Region: tmk; PRK00698
261292004100	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
261292004101	TMP-binding site; other site
261292004102	ATP-binding site [chemical binding]; other site
261292004103	DNA polymerase III subunit delta'; Validated; Region: PRK06964
261292004104	DNA polymerase III subunit delta'; Validated; Region: PRK08485
261292004105	Domain of unknown function (DUF336); Region: DUF336; pfam03928
261292004106	Dienelactone hydrolase family; Region: DLH; pfam01738
261292004107	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
261292004108	Uncharacterized conserved protein [Function unknown]; Region: COG1262
261292004109	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
261292004110	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
261292004111	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
261292004112	Uncharacterized conserved protein [Function unknown]; Region: COG1262
261292004113	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
261292004114	TIR domain; Region: TIR_2; pfam13676
261292004115	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
261292004116	non-specific DNA binding site [nucleotide binding]; other site
261292004117	salt bridge; other site
261292004118	sequence-specific DNA binding site [nucleotide binding]; other site
261292004119	Plasmid maintenance system killer protein; Region: Plasmid_killer; pfam05015
261292004120	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183
261292004121	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
261292004122	putative active site [active]
261292004123	metal binding site [ion binding]; metal-binding site
261292004124	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
261292004125	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
261292004126	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
261292004127	Transposase [DNA replication, recombination, and repair]; Region: COG5433
261292004128	Transposase [DNA replication, recombination, and repair]; Region: COG5433
261292004129	BON domain; Region: BON; pfam04972
261292004130	BON domain; Region: BON; pfam04972
261292004131	CsbD-like; Region: CsbD; cl17424
261292004132	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
261292004133	Major Facilitator Superfamily; Region: MFS_1; pfam07690
261292004134	putative substrate translocation pore; other site
261292004135	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
261292004136	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
261292004137	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
261292004138	RNase E interface [polypeptide binding]; other site
261292004139	trimer interface [polypeptide binding]; other site
261292004140	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
261292004141	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
261292004142	RNase E interface [polypeptide binding]; other site
261292004143	trimer interface [polypeptide binding]; other site
261292004144	active site
261292004145	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
261292004146	putative nucleic acid binding region [nucleotide binding]; other site
261292004147	G-X-X-G motif; other site
261292004148	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
261292004149	RNA binding site [nucleotide binding]; other site
261292004150	domain interface; other site
261292004151	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
261292004152	16S/18S rRNA binding site [nucleotide binding]; other site
261292004153	S13e-L30e interaction site [polypeptide binding]; other site
261292004154	25S rRNA binding site [nucleotide binding]; other site
261292004155	PBP superfamily domain; Region: PBP_like_2; cl17296
261292004156	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
261292004157	Ammonia monooxygenase/methane monooxygenase, subunit C; Region: AmoC; pfam04896
261292004158	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
261292004159	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
261292004160	Coenzyme A binding pocket [chemical binding]; other site
261292004161	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
261292004162	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
261292004163	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
261292004164	Protein of unknown function, DUF484; Region: DUF484; cl17449
261292004165	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
261292004166	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
261292004167	active site
261292004168	DNA binding site [nucleotide binding]
261292004169	Int/Topo IB signature motif; other site
261292004170	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
261292004171	active site
261292004172	HslU subunit interaction site [polypeptide binding]; other site
261292004173	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
261292004174	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
261292004175	Walker A motif; other site
261292004176	ATP binding site [chemical binding]; other site
261292004177	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
261292004178	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
261292004179	Laminin B (Domain IV); Region: Laminin_B; cl02548
261292004180	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
261292004181	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
261292004182	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
261292004183	dimer interface [polypeptide binding]; other site
261292004184	anticodon binding site; other site
261292004185	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
261292004186	homodimer interface [polypeptide binding]; other site
261292004187	motif 1; other site
261292004188	active site
261292004189	motif 2; other site
261292004190	GAD domain; Region: GAD; pfam02938
261292004191	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
261292004192	motif 3; other site
261292004193	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
261292004194	nudix motif; other site
261292004195	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
261292004196	Sulfate transporter family; Region: Sulfate_transp; pfam00916
261292004197	Carboxysome Shell Carbonic Anhydrase; Region: CsoSCA; cl07510
261292004198	NADH dehydrogenase subunit 2; Provisional; Region: ND2; MTH00197
261292004199	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
261292004200	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
261292004201	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
261292004202	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
261292004203	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
261292004204	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
261292004205	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
261292004206	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
261292004207	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
261292004208	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
261292004209	Helix-turn-helix domain; Region: HTH_28; pfam13518
261292004210	Winged helix-turn helix; Region: HTH_29; pfam13551
261292004211	Winged helix-turn helix; Region: HTH_33; pfam13592
261292004212	DDE superfamily endonuclease; Region: DDE_3; pfam13358
261292004213	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
261292004214	Transposase domain (DUF772); Region: DUF772; pfam05598
261292004215	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
261292004216	DDE superfamily endonuclease; Region: DDE_4; cl17710
261292004217	SEFIR domain; Region: SEFIR; pfam08357
261292004218	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
261292004219	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
261292004220	Walker A motif; other site
261292004221	ATP binding site [chemical binding]; other site
261292004222	Walker B motif; other site
261292004223	arginine finger; other site
261292004224	Uncharacterized conserved protein [Function unknown]; Region: COG1262
261292004225	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
261292004226	Uncharacterized conserved protein [Function unknown]; Region: COG1262
261292004227	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
261292004228	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
261292004229	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
261292004230	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
261292004231	transmembrane helices; other site
261292004232	TrkA-C domain; Region: TrkA_C; pfam02080
261292004233	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
261292004234	TrkA-C domain; Region: TrkA_C; pfam02080
261292004235	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
261292004236	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cl00208
261292004237	CAS motifs; other site
261292004238	active site
261292004239	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
261292004240	active site
261292004241	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
261292004242	Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly.  The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111
261292004243	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
261292004244	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
261292004245	Methyltransferase domain; Region: Methyltransf_11; pfam08241
261292004246	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
261292004247	RNA/DNA hybrid binding site [nucleotide binding]; other site
261292004248	active site
261292004249	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
261292004250	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
261292004251	active site
261292004252	catalytic site [active]
261292004253	substrate binding site [chemical binding]; other site
261292004254	Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344
261292004255	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
261292004256	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292004257	active site
261292004258	phosphorylation site [posttranslational modification]
261292004259	intermolecular recognition site; other site
261292004260	dimerization interface [polypeptide binding]; other site
261292004261	tetraacyldisaccharide 4'-kinase; Provisional; Region: PRK01906
261292004262	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
261292004263	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
261292004264	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
261292004265	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
261292004266	ATP binding site [chemical binding]; other site
261292004267	substrate interface [chemical binding]; other site
261292004268	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
261292004269	active site residue [active]
261292004270	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
261292004271	MPN+ (JAMM) motif; other site
261292004272	Zinc-binding site [ion binding]; other site
261292004273	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
261292004274	MoaE interaction surface [polypeptide binding]; other site
261292004275	MoeB interaction surface [polypeptide binding]; other site
261292004276	thiocarboxylated glycine; other site
261292004277	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
261292004278	CoA-transferase family III; Region: CoA_transf_3; pfam02515
261292004279	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
261292004280	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
261292004281	acyl-activating enzyme (AAE) consensus motif; other site
261292004282	AMP binding site [chemical binding]; other site
261292004283	active site
261292004284	CoA binding site [chemical binding]; other site
261292004285	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
261292004286	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
261292004287	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
261292004288	active site
261292004289	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
261292004290	putative substrate translocation pore; other site
261292004291	Major Facilitator Superfamily; Region: MFS_1; pfam07690
261292004292	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
261292004293	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
261292004294	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
261292004295	catalytic site [active]
261292004296	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
261292004297	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
261292004298	Transposase [DNA replication, recombination, and repair]; Region: COG5433
261292004299	Transposase [DNA replication, recombination, and repair]; Region: COG5433
261292004300	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
261292004301	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
261292004302	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
261292004303	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
261292004304	active site
261292004305	PEP-CTERM motif; Region: VPEP; pfam07589
261292004306	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
261292004307	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
261292004308	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
261292004309	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
261292004310	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
261292004311	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
261292004312	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
261292004313	active site
261292004314	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
261292004315	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
261292004316	FeS/SAM binding site; other site
261292004317	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
261292004318	active site
261292004319	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
261292004320	active site
261292004321	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
261292004322	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
261292004323	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
261292004324	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
261292004325	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
261292004326	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
261292004327	NADP binding site [chemical binding]; other site
261292004328	homodimer interface [polypeptide binding]; other site
261292004329	active site
261292004330	substrate binding site [chemical binding]; other site
261292004331	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
261292004332	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
261292004333	hexamer interface [polypeptide binding]; other site
261292004334	ligand binding site [chemical binding]; other site
261292004335	putative active site [active]
261292004336	NAD(P) binding site [chemical binding]; other site
261292004337	HDOD domain; Region: HDOD; pfam08668
261292004338	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
261292004339	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
261292004340	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
261292004341	non-specific DNA binding site [nucleotide binding]; other site
261292004342	salt bridge; other site
261292004343	sequence-specific DNA binding site [nucleotide binding]; other site
261292004344	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
261292004345	hypothetical protein; Provisional; Region: PRK11820
261292004346	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
261292004347	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
261292004348	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
261292004349	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
261292004350	G1 box; other site
261292004351	putative GEF interaction site [polypeptide binding]; other site
261292004352	GTP/Mg2+ binding site [chemical binding]; other site
261292004353	Switch I region; other site
261292004354	G2 box; other site
261292004355	G3 box; other site
261292004356	Switch II region; other site
261292004357	G4 box; other site
261292004358	G5 box; other site
261292004359	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
261292004360	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
261292004361	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
261292004362	Walker A/P-loop; other site
261292004363	ATP binding site [chemical binding]; other site
261292004364	Q-loop/lid; other site
261292004365	ABC transporter signature motif; other site
261292004366	Walker B; other site
261292004367	D-loop; other site
261292004368	H-loop/switch region; other site
261292004369	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
261292004370	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
261292004371	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
261292004372	Walker A/P-loop; other site
261292004373	ATP binding site [chemical binding]; other site
261292004374	Q-loop/lid; other site
261292004375	ABC transporter signature motif; other site
261292004376	Walker B; other site
261292004377	D-loop; other site
261292004378	H-loop/switch region; other site
261292004379	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
261292004380	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
261292004381	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
261292004382	dimer interface [polypeptide binding]; other site
261292004383	conserved gate region; other site
261292004384	putative PBP binding loops; other site
261292004385	ABC-ATPase subunit interface; other site
261292004386	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
261292004387	TPR repeat; Region: TPR_11; pfam13414
261292004388	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
261292004389	TPR motif; other site
261292004390	binding surface
261292004391	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
261292004392	HIRAN domain; Region: HIRAN; cl07418
261292004393	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
261292004394	catalytic residues [active]
261292004395	dimer interface [polypeptide binding]; other site
261292004396	Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746
261292004397	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
261292004398	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
261292004399	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
261292004400	FtsX-like permease family; Region: FtsX; pfam02687
261292004401	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
261292004402	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
261292004403	ligand binding site [chemical binding]; other site
261292004404	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
261292004405	putative catalytic site [active]
261292004406	putative metal binding site [ion binding]; other site
261292004407	putative phosphate binding site [ion binding]; other site
261292004408	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
261292004409	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
261292004410	FtsX-like permease family; Region: FtsX; pfam02687
261292004411	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
261292004412	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
261292004413	Walker A/P-loop; other site
261292004414	ATP binding site [chemical binding]; other site
261292004415	Q-loop/lid; other site
261292004416	ABC transporter signature motif; other site
261292004417	Walker B; other site
261292004418	D-loop; other site
261292004419	H-loop/switch region; other site
261292004420	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
261292004421	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
261292004422	HlyD family secretion protein; Region: HlyD_3; pfam13437
261292004423	ATP-binding cassette domain of MutS homologs; Region: ABC_MutS_homologs; cd03243
261292004424	Walker A/P-loop; other site
261292004425	ATP binding site [chemical binding]; other site
261292004426	Q-loop/lid; other site
261292004427	ABC transporter signature motif; other site
261292004428	Walker B; other site
261292004429	D-loop; other site
261292004430	H-loop/switch region; other site
261292004431	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
261292004432	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
261292004433	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
261292004434	CoA-ligase; Region: Ligase_CoA; pfam00549
261292004435	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
261292004436	CoA binding domain; Region: CoA_binding; smart00881
261292004437	CoA-ligase; Region: Ligase_CoA; pfam00549
261292004438	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
261292004439	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
261292004440	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
261292004441	Helix-turn-helix domain; Region: HTH_28; pfam13518
261292004442	Winged helix-turn helix; Region: HTH_29; pfam13551
261292004443	Winged helix-turn helix; Region: HTH_33; pfam13592
261292004444	DDE superfamily endonuclease; Region: DDE_3; pfam13358
261292004445	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
261292004446	anthranilate synthase component I; Provisional; Region: PRK13565
261292004447	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
261292004448	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
261292004449	phosphoglycolate phosphatase; Provisional; Region: PRK13222
261292004450	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
261292004451	motif II; other site
261292004452	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
261292004453	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
261292004454	substrate binding site [chemical binding]; other site
261292004455	hexamer interface [polypeptide binding]; other site
261292004456	metal binding site [ion binding]; metal-binding site
261292004457	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
261292004458	Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649
261292004459	putative SAM binding site [chemical binding]; other site
261292004460	homodimer interface [polypeptide binding]; other site
261292004461	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
261292004462	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
261292004463	dimer interface [polypeptide binding]; other site
261292004464	active site
261292004465	metal binding site [ion binding]; metal-binding site
261292004466	glutathione binding site [chemical binding]; other site
261292004467	Rubredoxin [Energy production and conversion]; Region: COG1773
261292004468	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
261292004469	iron binding site [ion binding]; other site
261292004470	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
261292004471	dimer interface [polypeptide binding]; other site
261292004472	substrate binding site [chemical binding]; other site
261292004473	ATP binding site [chemical binding]; other site
261292004474	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
261292004475	thiamine phosphate binding site [chemical binding]; other site
261292004476	active site
261292004477	pyrophosphate binding site [ion binding]; other site
261292004478	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
261292004479	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
261292004480	inhibitor-cofactor binding pocket; inhibition site
261292004481	pyridoxal 5'-phosphate binding site [chemical binding]; other site
261292004482	catalytic residue [active]
261292004483	Cytochrome c553 [Energy production and conversion]; Region: COG2863
261292004484	Cytochrome c; Region: Cytochrom_C; cl11414
261292004485	Sporulation related domain; Region: SPOR; cl10051
261292004486	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
261292004487	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
261292004488	active site
261292004489	ribonuclease PH; Reviewed; Region: rph; PRK00173
261292004490	Ribonuclease PH; Region: RNase_PH_bact; cd11362
261292004491	hexamer interface [polypeptide binding]; other site
261292004492	active site
261292004493	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
261292004494	active site
261292004495	dimerization interface [polypeptide binding]; other site
261292004496	S-formylglutathione hydrolase; Region: PLN02442
261292004497	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
261292004498	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
261292004499	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
261292004500	substrate binding site [chemical binding]; other site
261292004501	catalytic Zn binding site [ion binding]; other site
261292004502	NAD binding site [chemical binding]; other site
261292004503	structural Zn binding site [ion binding]; other site
261292004504	dimer interface [polypeptide binding]; other site
261292004505	Low molecular weight phosphatase family; Region: LMWPc; cd00115
261292004506	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
261292004507	active site
261292004508	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
261292004509	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
261292004510	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
261292004511	nucleoside/Zn binding site; other site
261292004512	dimer interface [polypeptide binding]; other site
261292004513	catalytic motif [active]
261292004514	HemK family putative methylases; Region: hemK_fam; TIGR00536
261292004515	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
261292004516	S-adenosylmethionine binding site [chemical binding]; other site
261292004517	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
261292004518	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
261292004519	RNA binding surface [nucleotide binding]; other site
261292004520	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
261292004521	probable active site [active]
261292004522	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
261292004523	hypothetical protein; Validated; Region: PRK00153
261292004524	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14969
261292004525	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
261292004526	Walker A motif; other site
261292004527	ATP binding site [chemical binding]; other site
261292004528	Walker B motif; other site
261292004529	arginine finger; other site
261292004530	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
261292004531	GAF domain; Region: GAF; cl17456
261292004532	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
261292004533	Zn2+ binding site [ion binding]; other site
261292004534	Mg2+ binding site [ion binding]; other site
261292004535	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
261292004536	RecB family nuclease, putative, TM0106 family; Region: TIGR03491
261292004537	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
261292004538	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
261292004539	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
261292004540	Substrate binding site; other site
261292004541	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
261292004542	Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881
261292004543	Iron-sulfur protein interface; other site
261292004544	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
261292004545	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
261292004546	active site
261292004547	DNA binding site [nucleotide binding]
261292004548	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
261292004549	putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968
261292004550	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
261292004551	NAD(P) binding site [chemical binding]; other site
261292004552	catalytic residues [active]
261292004553	Uncharacterized conserved protein [Function unknown]; Region: COG1262
261292004554	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
261292004555	Chromate resistance exported protein; Region: Chrome_Resist; pfam09828
261292004556	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
261292004557	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
261292004558	Chromate transporter; Region: Chromate_transp; pfam02417
261292004559	Chromate resistance exported protein; Region: Chrome_Resist; pfam09828
261292004560	Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547
261292004561	dihydroxyacetone kinase; Provisional; Region: PRK14479
261292004562	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
261292004563	DAK2 domain; Region: Dak2; pfam02734
261292004564	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
261292004565	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
261292004566	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
261292004567	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
261292004568	active site
261292004569	HIGH motif; other site
261292004570	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
261292004571	active site
261292004572	KMSKS motif; other site
261292004573	acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098
261292004574	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
261292004575	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922
261292004576	acyl-activating enzyme (AAE) consensus motif; other site
261292004577	acyl-activating enzyme (AAE) consensus motif; other site
261292004578	putative AMP binding site [chemical binding]; other site
261292004579	putative active site [active]
261292004580	putative CoA binding site [chemical binding]; other site
261292004581	pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099
261292004582	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839
261292004583	dimer interface [polypeptide binding]; other site
261292004584	active site
261292004585	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
261292004586	catalytic residues [active]
261292004587	substrate binding site [chemical binding]; other site
261292004588	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
261292004589	PBP superfamily domain; Region: PBP_like_2; cl17296
261292004590	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
261292004591	dimer interface [polypeptide binding]; other site
261292004592	PAS domain S-box; Region: sensory_box; TIGR00229
261292004593	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292004594	putative active site [active]
261292004595	heme pocket [chemical binding]; other site
261292004596	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
261292004597	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
261292004598	metal binding site [ion binding]; metal-binding site
261292004599	active site
261292004600	I-site; other site
261292004601	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
261292004602	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
261292004603	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
261292004604	Beta-Casp domain; Region: Beta-Casp; smart01027
261292004605	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
261292004606	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06943
261292004607	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
261292004608	inhibitor-cofactor binding pocket; inhibition site
261292004609	pyridoxal 5'-phosphate binding site [chemical binding]; other site
261292004610	catalytic residue [active]
261292004611	Protein of unknown function (DUF3422); Region: DUF3422; pfam11902
261292004612	adenylosuccinate lyase; Provisional; Region: PRK09285
261292004613	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
261292004614	tetramer interface [polypeptide binding]; other site
261292004615	active site
261292004616	GrpE; Region: GrpE; pfam01025
261292004617	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
261292004618	dimer interface [polypeptide binding]; other site
261292004619	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
261292004620	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
261292004621	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
261292004622	nucleotide binding site [chemical binding]; other site
261292004623	chaperone protein DnaJ; Provisional; Region: PRK10767
261292004624	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
261292004625	HSP70 interaction site [polypeptide binding]; other site
261292004626	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
261292004627	substrate binding site [polypeptide binding]; other site
261292004628	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
261292004629	Zn binding sites [ion binding]; other site
261292004630	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
261292004631	dimer interface [polypeptide binding]; other site
261292004632	Transposase domain (DUF772); Region: DUF772; pfam05598
261292004633	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
261292004634	Winged helix-turn helix; Region: HTH_29; pfam13551
261292004635	Winged helix-turn helix; Region: HTH_33; pfam13592
261292004636	DDE superfamily endonuclease; Region: DDE_3; pfam13358
261292004637	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
261292004638	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
261292004639	Transposase; Region: HTH_Tnp_1; pfam01527
261292004640	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
261292004641	Transposase; Region: DEDD_Tnp_IS110; pfam01548
261292004642	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
261292004643	Transposase domain (DUF772); Region: DUF772; pfam05598
261292004644	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
261292004645	putative transcription regulator; Region: PHA01082
261292004646	Transposase domain (DUF772); Region: DUF772; pfam05598
261292004647	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
261292004648	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
261292004649	oligomer interface [polypeptide binding]; other site
261292004650	metal binding site [ion binding]; metal-binding site
261292004651	metal binding site [ion binding]; metal-binding site
261292004652	Cl binding site [ion binding]; other site
261292004653	aspartate ring; other site
261292004654	basic sphincter; other site
261292004655	putative hydrophobic gate; other site
261292004656	periplasmic entrance; other site
261292004657	Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075
261292004658	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
261292004659	active site
261292004660	tetramer interface; other site
261292004661	UDP-glucose 4-epimerase; Region: PLN02240
261292004662	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
261292004663	NAD binding site [chemical binding]; other site
261292004664	homodimer interface [polypeptide binding]; other site
261292004665	active site
261292004666	substrate binding site [chemical binding]; other site
261292004667	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
261292004668	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
261292004669	CysD dimerization site [polypeptide binding]; other site
261292004670	G1 box; other site
261292004671	putative GEF interaction site [polypeptide binding]; other site
261292004672	GTP/Mg2+ binding site [chemical binding]; other site
261292004673	Switch I region; other site
261292004674	G2 box; other site
261292004675	G3 box; other site
261292004676	Switch II region; other site
261292004677	G4 box; other site
261292004678	G5 box; other site
261292004679	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
261292004680	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
261292004681	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
261292004682	ligand-binding site [chemical binding]; other site
261292004683	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
261292004684	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
261292004685	Active Sites [active]
261292004686	Protein of unknown function (DUF3616); Region: DUF3616; pfam12275
261292004687	PEP-CTERM motif; Region: VPEP; pfam07589
261292004688	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
261292004689	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
261292004690	catalytic residue [active]
261292004691	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994
261292004692	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
261292004693	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
261292004694	active site
261292004695	HIGH motif; other site
261292004696	KMSKS motif; other site
261292004697	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
261292004698	tRNA binding surface [nucleotide binding]; other site
261292004699	anticodon binding site; other site
261292004700	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
261292004701	dimer interface [polypeptide binding]; other site
261292004702	putative tRNA-binding site [nucleotide binding]; other site
261292004703	Domain of unknown function DUF59; Region: DUF59; pfam01883
261292004704	antiporter inner membrane protein; Provisional; Region: PRK11670
261292004705	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
261292004706	Walker A motif; other site
261292004707	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
261292004708	trimer interface [polypeptide binding]; other site
261292004709	active site
261292004710	TIGR03790 family protein; Region: TIGR03790
261292004711	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
261292004712	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
261292004713	active site
261292004714	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
261292004715	dimer interface [polypeptide binding]; other site
261292004716	catalytic residues [active]
261292004717	substrate binding site [chemical binding]; other site
261292004718	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
261292004719	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
261292004720	folate binding site [chemical binding]; other site
261292004721	NADP+ binding site [chemical binding]; other site
261292004722	thymidylate synthase; Reviewed; Region: thyA; PRK01827
261292004723	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
261292004724	dimerization interface [polypeptide binding]; other site
261292004725	active site
261292004726	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
261292004727	interface (dimer of trimers) [polypeptide binding]; other site
261292004728	Substrate-binding/catalytic site; other site
261292004729	Zn-binding sites [ion binding]; other site
261292004730	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
261292004731	N-acetyl-D-glucosamine binding site [chemical binding]; other site
261292004732	catalytic residue [active]
261292004733	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
261292004734	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
261292004735	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
261292004736	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
261292004737	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
261292004738	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
261292004739	Walker A/P-loop; other site
261292004740	ATP binding site [chemical binding]; other site
261292004741	Q-loop/lid; other site
261292004742	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470
261292004743	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
261292004744	ABC transporter signature motif; other site
261292004745	Walker B; other site
261292004746	D-loop; other site
261292004747	H-loop/switch region; other site
261292004748	ZipA, C-terminal domain (FtsZ-binding); Region: ZipA_C; smart00771
261292004749	FtsZ protein binding site [polypeptide binding]; other site
261292004750	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
261292004751	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
261292004752	Cell division protein ZapA; Region: ZapA; pfam05164
261292004753	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
261292004754	?-D-glucose-1-phosphatase; Provisional; Region: PRK09456
261292004755	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
261292004756	EVE domain; Region: EVE; cl00728
261292004757	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
261292004758	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
261292004759	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
261292004760	metal binding site [ion binding]; metal-binding site
261292004761	active site
261292004762	I-site; other site
261292004763	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
261292004764	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
261292004765	putative NAD(P) binding site [chemical binding]; other site
261292004766	Transposase domain (DUF772); Region: DUF772; pfam05598
261292004767	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
261292004768	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
261292004769	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
261292004770	putative ADP-binding pocket [chemical binding]; other site
261292004771	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
261292004772	Winged helix-turn helix; Region: HTH_29; pfam13551
261292004773	Helix-turn-helix domain; Region: HTH_28; pfam13518
261292004774	Transposase domain (DUF772); Region: DUF772; pfam05598
261292004775	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
261292004776	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
261292004777	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
261292004778	substrate binding site [chemical binding]; other site
261292004779	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
261292004780	putative FMN binding site [chemical binding]; other site
261292004781	NADPH bind site [chemical binding]; other site
261292004782	hypothetical protein; Provisional; Region: PRK09256
261292004783	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
261292004784	Protein of unknown function (DUF1415); Region: DUF1415; pfam07209
261292004785	serine/threonine protein kinase; Provisional; Region: PRK11768
261292004786	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
261292004787	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
261292004788	integrase; Provisional; Region: PRK09692
261292004789	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
261292004790	active site
261292004791	Int/Topo IB signature motif; other site
261292004792	putative transposase OrfB; Reviewed; Region: PHA02517
261292004793	HTH-like domain; Region: HTH_21; pfam13276
261292004794	Integrase core domain; Region: rve; pfam00665
261292004795	Integrase core domain; Region: rve_3; cl15866
261292004796	Transposase; Region: HTH_Tnp_1; cl17663
261292004797	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
261292004798	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
261292004799	Ligand binding site; other site
261292004800	Putative Catalytic site; other site
261292004801	DXD motif; other site
261292004802	Predicted membrane protein [Function unknown]; Region: COG2246
261292004803	GtrA-like protein; Region: GtrA; pfam04138
261292004804	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
261292004805	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
261292004806	Methyltransferase domain; Region: Methyltransf_12; pfam08242
261292004807	HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795
261292004808	hypothetical protein; Provisional; Region: PRK09272
261292004809	Transposase; Region: HTH_Tnp_1; pfam01527
261292004810	putative transposase OrfB; Reviewed; Region: PHA02517
261292004811	HTH-like domain; Region: HTH_21; pfam13276
261292004812	Integrase core domain; Region: rve; pfam00665
261292004813	Integrase core domain; Region: rve_3; cl15866
261292004814	Domain of unknown function (DUF1917); Region: DUF1917; pfam08939
261292004815	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
261292004816	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
261292004817	active site clefts [active]
261292004818	zinc binding site [ion binding]; other site
261292004819	dimer interface [polypeptide binding]; other site
261292004820	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
261292004821	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
261292004822	Walker A motif; other site
261292004823	ATP binding site [chemical binding]; other site
261292004824	Walker B motif; other site
261292004825	arginine finger; other site
261292004826	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
261292004827	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
261292004828	plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647
261292004829	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
261292004830	Soluble P-type ATPase [General function prediction only]; Region: COG4087
261292004831	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
261292004832	DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453
261292004833	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
261292004834	FAD binding pocket [chemical binding]; other site
261292004835	conserved FAD binding motif [chemical binding]; other site
261292004836	phosphate binding motif [ion binding]; other site
261292004837	beta-alpha-beta structure motif; other site
261292004838	NAD binding pocket [chemical binding]; other site
261292004839	PBP superfamily domain; Region: PBP_like_2; cl17296
261292004840	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
261292004841	HAMP domain; Region: HAMP; pfam00672
261292004842	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
261292004843	dimer interface [polypeptide binding]; other site
261292004844	phosphorylation site [posttranslational modification]
261292004845	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292004846	ATP binding site [chemical binding]; other site
261292004847	Mg2+ binding site [ion binding]; other site
261292004848	G-X-G motif; other site
261292004849	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
261292004850	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292004851	active site
261292004852	phosphorylation site [posttranslational modification]
261292004853	intermolecular recognition site; other site
261292004854	dimerization interface [polypeptide binding]; other site
261292004855	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
261292004856	DNA binding site [nucleotide binding]
261292004857	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
261292004858	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
261292004859	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
261292004860	Transposase [DNA replication, recombination, and repair]; Region: COG5433
261292004861	Transposase [DNA replication, recombination, and repair]; Region: COG5433
261292004862	aspartate kinase; Reviewed; Region: PRK06635
261292004863	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
261292004864	putative nucleotide binding site [chemical binding]; other site
261292004865	putative catalytic residues [active]
261292004866	putative Mg ion binding site [ion binding]; other site
261292004867	putative aspartate binding site [chemical binding]; other site
261292004868	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
261292004869	putative allosteric regulatory site; other site
261292004870	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
261292004871	putative allosteric regulatory residue; other site
261292004872	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
261292004873	intersubunit interface [polypeptide binding]; other site
261292004874	active site
261292004875	Zn2+ binding site [ion binding]; other site
261292004876	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
261292004877	RNA binding surface [nucleotide binding]; other site
261292004878	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
261292004879	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
261292004880	Ribosome inactivating protein; Region: RIP; pfam00161
261292004881	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
261292004882	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
261292004883	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
261292004884	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
261292004885	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
261292004886	homodimer interface [polypeptide binding]; other site
261292004887	substrate-cofactor binding pocket; other site
261292004888	catalytic residue [active]
261292004889	Zinc-finger domain; Region: zf-CHCC; cl01821
261292004890	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
261292004891	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
261292004892	active site
261292004893	substrate binding site [chemical binding]; other site
261292004894	metal binding site [ion binding]; metal-binding site
261292004895	NAD synthetase; Provisional; Region: PRK13981
261292004896	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
261292004897	multimer interface [polypeptide binding]; other site
261292004898	active site
261292004899	catalytic triad [active]
261292004900	protein interface 1 [polypeptide binding]; other site
261292004901	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
261292004902	homodimer interface [polypeptide binding]; other site
261292004903	NAD binding pocket [chemical binding]; other site
261292004904	ATP binding pocket [chemical binding]; other site
261292004905	Mg binding site [ion binding]; other site
261292004906	active-site loop [active]
261292004907	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
261292004908	Peptidase family M48; Region: Peptidase_M48; pfam01435
261292004909	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
261292004910	TPR motif; other site
261292004911	binding surface
261292004912	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
261292004913	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
261292004914	HlyD family secretion protein; Region: HlyD_3; pfam13437
261292004915	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
261292004916	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
261292004917	Walker A/P-loop; other site
261292004918	ATP binding site [chemical binding]; other site
261292004919	Q-loop/lid; other site
261292004920	ABC transporter signature motif; other site
261292004921	Walker B; other site
261292004922	D-loop; other site
261292004923	H-loop/switch region; other site
261292004924	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
261292004925	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
261292004926	FtsX-like permease family; Region: FtsX; pfam02687
261292004927	Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055
261292004928	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
261292004929	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292004930	ATP binding site [chemical binding]; other site
261292004931	Mg2+ binding site [ion binding]; other site
261292004932	G-X-G motif; other site
261292004933	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
261292004934	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292004935	active site
261292004936	phosphorylation site [posttranslational modification]
261292004937	intermolecular recognition site; other site
261292004938	dimerization interface [polypeptide binding]; other site
261292004939	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
261292004940	DNA binding residues [nucleotide binding]
261292004941	dimerization interface [polypeptide binding]; other site
261292004942	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
261292004943	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
261292004944	ribonuclease G; Provisional; Region: PRK11712
261292004945	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
261292004946	homodimer interface [polypeptide binding]; other site
261292004947	oligonucleotide binding site [chemical binding]; other site
261292004948	Maf-like protein; Region: Maf; pfam02545
261292004949	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
261292004950	active site
261292004951	dimer interface [polypeptide binding]; other site
261292004952	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
261292004953	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
261292004954	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
261292004955	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
261292004956	active site
261292004957	(T/H)XGH motif; other site
261292004958	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
261292004959	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
261292004960	E3 interaction surface; other site
261292004961	lipoyl attachment site [posttranslational modification]; other site
261292004962	e3 binding domain; Region: E3_binding; pfam02817
261292004963	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
261292004964	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
261292004965	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
261292004966	dimer interface [polypeptide binding]; other site
261292004967	TPP-binding site [chemical binding]; other site
261292004968	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
261292004969	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189
261292004970	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
261292004971	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
261292004972	homodimer interface [polypeptide binding]; other site
261292004973	NADP binding site [chemical binding]; other site
261292004974	substrate binding site [chemical binding]; other site
261292004975	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
261292004976	FAD binding site [chemical binding]; other site
261292004977	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
261292004978	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
261292004979	homotetramer interface [polypeptide binding]; other site
261292004980	ligand binding site [chemical binding]; other site
261292004981	catalytic site [active]
261292004982	NAD binding site [chemical binding]; other site
261292004983	S-adenosylmethionine synthetase; Validated; Region: PRK05250
261292004984	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
261292004985	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
261292004986	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
261292004987	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
261292004988	Uncharacterized conserved protein [Function unknown]; Region: COG3379
261292004989	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
261292004990	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
261292004991	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
261292004992	active site
261292004993	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
261292004994	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
261292004995	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
261292004996	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
261292004997	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
261292004998	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
261292004999	phosphate binding site [ion binding]; other site
261292005000	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
261292005001	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
261292005002	active site
261292005003	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
261292005004	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
261292005005	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
261292005006	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
261292005007	putative NADP binding site [chemical binding]; other site
261292005008	active site
261292005009	Transposase IS200 like; Region: Y1_Tnp; pfam01797
261292005010	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
261292005011	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
261292005012	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
261292005013	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
261292005014	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
261292005015	putative catalytic site [active]
261292005016	putative metal binding site [ion binding]; other site
261292005017	putative phosphate binding site [ion binding]; other site
261292005018	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
261292005019	Found in ATP-dependent protease La (LON); Region: LON; smart00464
261292005020	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
261292005021	Walker A motif; other site
261292005022	ATP binding site [chemical binding]; other site
261292005023	Walker B motif; other site
261292005024	arginine finger; other site
261292005025	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
261292005026	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
261292005027	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
261292005028	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
261292005029	Walker A motif; other site
261292005030	ATP binding site [chemical binding]; other site
261292005031	Walker B motif; other site
261292005032	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
261292005033	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
261292005034	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
261292005035	oligomer interface [polypeptide binding]; other site
261292005036	active site residues [active]
261292005037	trigger factor; Provisional; Region: tig; PRK01490
261292005038	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
261292005039	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
261292005040	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
261292005041	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
261292005042	NAD(P) binding site [chemical binding]; other site
261292005043	active site
261292005044	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
261292005045	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
261292005046	ring oligomerisation interface [polypeptide binding]; other site
261292005047	ATP/Mg binding site [chemical binding]; other site
261292005048	stacking interactions; other site
261292005049	hinge regions; other site
261292005050	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
261292005051	oligomerisation interface [polypeptide binding]; other site
261292005052	mobile loop; other site
261292005053	roof hairpin; other site
261292005054	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
261292005055	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
261292005056	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
261292005057	PAS domain S-box; Region: sensory_box; TIGR00229
261292005058	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292005059	putative active site [active]
261292005060	heme pocket [chemical binding]; other site
261292005061	PAS domain S-box; Region: sensory_box; TIGR00229
261292005062	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292005063	putative active site [active]
261292005064	heme pocket [chemical binding]; other site
261292005065	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
261292005066	Histidine kinase; Region: HisKA_2; pfam07568
261292005067	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292005068	Mg2+ binding site [ion binding]; other site
261292005069	G-X-G motif; other site
261292005070	Response regulator receiver domain; Region: Response_reg; pfam00072
261292005071	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292005072	active site
261292005073	phosphorylation site [posttranslational modification]
261292005074	intermolecular recognition site; other site
261292005075	dimerization interface [polypeptide binding]; other site
261292005076	PAS fold; Region: PAS_3; pfam08447
261292005077	PAS domain; Region: PAS_9; pfam13426
261292005078	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
261292005079	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
261292005080	metal binding site [ion binding]; metal-binding site
261292005081	active site
261292005082	I-site; other site
261292005083	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
261292005084	Helix-turn-helix domain; Region: HTH_28; pfam13518
261292005085	Winged helix-turn helix; Region: HTH_29; pfam13551
261292005086	Winged helix-turn helix; Region: HTH_33; pfam13592
261292005087	DDE superfamily endonuclease; Region: DDE_3; pfam13358
261292005088	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
261292005089	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
261292005090	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
261292005091	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
261292005092	THF binding site; other site
261292005093	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
261292005094	substrate binding site [chemical binding]; other site
261292005095	THF binding site; other site
261292005096	zinc-binding site [ion binding]; other site
261292005097	Transcriptional regulator [Transcription]; Region: LysR; COG0583
261292005098	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
261292005099	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
261292005100	dimerization interface [polypeptide binding]; other site
261292005101	SIR2-like domain; Region: SIR2_2; pfam13289
261292005102	SEC-C motif; Region: SEC-C; pfam02810
261292005103	Predicted membrane protein [Function unknown]; Region: COG1238
261292005104	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
261292005105	putative GSH binding site [chemical binding]; other site
261292005106	catalytic residues [active]
261292005107	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
261292005108	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
261292005109	S-adenosylmethionine binding site [chemical binding]; other site
261292005110	peptide chain release factor 1; Validated; Region: prfA; PRK00591
261292005111	This domain is found in peptide chain release factors; Region: PCRF; smart00937
261292005112	RF-1 domain; Region: RF-1; pfam00472
261292005113	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
261292005114	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
261292005115	tRNA; other site
261292005116	putative tRNA binding site [nucleotide binding]; other site
261292005117	putative NADP binding site [chemical binding]; other site
261292005118	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
261292005119	CreA protein; Region: CreA; pfam05981
261292005120	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
261292005121	active site clefts [active]
261292005122	zinc binding site [ion binding]; other site
261292005123	dimer interface [polypeptide binding]; other site
261292005124	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
261292005125	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
261292005126	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
261292005127	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
261292005128	beta-hexosaminidase; Provisional; Region: PRK05337
261292005129	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
261292005130	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
261292005131	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
261292005132	active site
261292005133	hydrophilic channel; other site
261292005134	dimerization interface [polypeptide binding]; other site
261292005135	catalytic residues [active]
261292005136	active site lid [active]
261292005137	GTPase Era; Reviewed; Region: era; PRK00089
261292005138	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
261292005139	G1 box; other site
261292005140	GTP/Mg2+ binding site [chemical binding]; other site
261292005141	Switch I region; other site
261292005142	G2 box; other site
261292005143	Switch II region; other site
261292005144	G3 box; other site
261292005145	G4 box; other site
261292005146	G5 box; other site
261292005147	KH domain; Region: KH_2; pfam07650
261292005148	ribonuclease III; Reviewed; Region: rnc; PRK00102
261292005149	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
261292005150	dimerization interface [polypeptide binding]; other site
261292005151	active site
261292005152	metal binding site [ion binding]; metal-binding site
261292005153	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
261292005154	dsRNA binding site [nucleotide binding]; other site
261292005155	signal peptidase I; Provisional; Region: PRK10861
261292005156	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
261292005157	Catalytic site [active]
261292005158	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
261292005159	GTP-binding protein LepA; Provisional; Region: PRK05433
261292005160	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
261292005161	G1 box; other site
261292005162	putative GEF interaction site [polypeptide binding]; other site
261292005163	GTP/Mg2+ binding site [chemical binding]; other site
261292005164	Switch I region; other site
261292005165	G2 box; other site
261292005166	G3 box; other site
261292005167	Switch II region; other site
261292005168	G4 box; other site
261292005169	G5 box; other site
261292005170	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
261292005171	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
261292005172	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
261292005173	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
261292005174	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
261292005175	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
261292005176	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
261292005177	protein binding site [polypeptide binding]; other site
261292005178	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
261292005179	protein binding site [polypeptide binding]; other site
261292005180	anti-sigma E factor; Provisional; Region: rseB; PRK09455
261292005181	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
261292005182	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
261292005183	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
261292005184	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
261292005185	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
261292005186	DNA binding residues [nucleotide binding]
261292005187	L-aspartate oxidase; Provisional; Region: PRK09077
261292005188	L-aspartate oxidase; Provisional; Region: PRK06175
261292005189	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
261292005190	MEKHLA domain; Region: MEKHLA; pfam08670
261292005191	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
261292005192	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
261292005193	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
261292005194	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
261292005195	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
261292005196	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
261292005197	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
261292005198	Ligand Binding Site [chemical binding]; other site
261292005199	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
261292005200	GAF domain; Region: GAF_3; pfam13492
261292005201	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
261292005202	dimer interface [polypeptide binding]; other site
261292005203	phosphorylation site [posttranslational modification]
261292005204	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292005205	ATP binding site [chemical binding]; other site
261292005206	Mg2+ binding site [ion binding]; other site
261292005207	G-X-G motif; other site
261292005208	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
261292005209	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292005210	active site
261292005211	phosphorylation site [posttranslational modification]
261292005212	intermolecular recognition site; other site
261292005213	dimerization interface [polypeptide binding]; other site
261292005214	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
261292005215	DNA binding site [nucleotide binding]
261292005216	metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459
261292005217	integrase; Provisional; Region: PRK09692
261292005218	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
261292005219	active site
261292005220	Int/Topo IB signature motif; other site
261292005221	RES domain; Region: RES; pfam08808
261292005222	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
261292005223	ATP binding site [chemical binding]; other site
261292005224	active site
261292005225	substrate binding site [chemical binding]; other site
261292005226	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
261292005227	XdhC Rossmann domain; Region: XdhC_C; pfam13478
261292005228	ATP-grasp domain; Region: ATP-grasp; pfam02222
261292005229	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
261292005230	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
261292005231	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
261292005232	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
261292005233	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
261292005234	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
261292005235	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
261292005236	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
261292005237	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
261292005238	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
261292005239	NAD binding site [chemical binding]; other site
261292005240	dimerization interface [polypeptide binding]; other site
261292005241	product binding site; other site
261292005242	substrate binding site [chemical binding]; other site
261292005243	zinc binding site [ion binding]; other site
261292005244	catalytic residues [active]
261292005245	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
261292005246	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
261292005247	excinuclease ABC subunit B; Provisional; Region: PRK05298
261292005248	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
261292005249	ATP binding site [chemical binding]; other site
261292005250	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
261292005251	nucleotide binding region [chemical binding]; other site
261292005252	ATP-binding site [chemical binding]; other site
261292005253	Ultra-violet resistance protein B; Region: UvrB; pfam12344
261292005254	UvrB/uvrC motif; Region: UVR; pfam02151
261292005255	aspartate aminotransferase; Provisional; Region: PRK05764
261292005256	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
261292005257	pyridoxal 5'-phosphate binding site [chemical binding]; other site
261292005258	homodimer interface [polypeptide binding]; other site
261292005259	catalytic residue [active]
261292005260	Flagellar transcriptional activator (FlhC); Region: FlhC; pfam05280
261292005261	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
261292005262	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
261292005263	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
261292005264	metal binding site [ion binding]; metal-binding site
261292005265	active site
261292005266	I-site; other site
261292005267	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
261292005268	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
261292005269	active site
261292005270	DNA binding site [nucleotide binding]
261292005271	Int/Topo IB signature motif; other site
261292005272	Predicted membrane protein [Function unknown]; Region: COG3164
261292005273	NACHT domain; Region: NACHT; pfam05729
261292005274	Transposase domain (DUF772); Region: DUF772; pfam05598
261292005275	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
261292005276	DDE superfamily endonuclease; Region: DDE_4; cl17710
261292005277	TIR domain; Region: TIR_2; pfam13676
261292005278	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
261292005279	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
261292005280	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
261292005281	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
261292005282	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
261292005283	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
261292005284	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
261292005285	SurA N-terminal domain; Region: SurA_N; pfam09312
261292005286	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
261292005287	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
261292005288	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
261292005289	OstA-like protein; Region: OstA; cl00844
261292005290	Organic solvent tolerance protein; Region: OstA_C; pfam04453
261292005291	Predicted transcriptional regulator [Transcription]; Region: COG1959
261292005292	iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010
261292005293	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
261292005294	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
261292005295	putative ABC transporter; Region: ycf24; CHL00085
261292005296	sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131
261292005297	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
261292005298	Walker A/P-loop; other site
261292005299	ATP binding site [chemical binding]; other site
261292005300	Q-loop/lid; other site
261292005301	ABC transporter signature motif; other site
261292005302	Walker B; other site
261292005303	D-loop; other site
261292005304	H-loop/switch region; other site
261292005305	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
261292005306	FeS assembly protein SufD; Region: sufD; TIGR01981
261292005307	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
261292005308	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
261292005309	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
261292005310	catalytic residue [active]
261292005311	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
261292005312	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
261292005313	trimerization site [polypeptide binding]; other site
261292005314	active site
261292005315	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364
261292005316	NifU-like domain; Region: NifU; cl00484
261292005317	elongation factor P; Validated; Region: PRK00529
261292005318	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
261292005319	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
261292005320	RNA binding site [nucleotide binding]; other site
261292005321	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
261292005322	RNA binding site [nucleotide binding]; other site
261292005323	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394
261292005324	Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093
261292005325	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
261292005326	Short C-terminal domain; Region: SHOCT; pfam09851
261292005327	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
261292005328	Ligand Binding Site [chemical binding]; other site
261292005329	Bacterial SH3 domain; Region: SH3_3; pfam08239
261292005330	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
261292005331	dimerization interface [polypeptide binding]; other site
261292005332	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
261292005333	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
261292005334	metal binding site [ion binding]; metal-binding site
261292005335	active site
261292005336	I-site; other site
261292005337	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
261292005338	apolar tunnel; other site
261292005339	heme binding site [chemical binding]; other site
261292005340	dimerization interface [polypeptide binding]; other site
261292005341	malate dehydrogenase; Provisional; Region: PRK13529
261292005342	Malic enzyme, N-terminal domain; Region: malic; pfam00390
261292005343	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
261292005344	NAD(P) binding site [chemical binding]; other site
261292005345	Domain of unknown function (DUF4072); Region: DUF4072; pfam13284
261292005346	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
261292005347	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
261292005348	motif II; other site
261292005349	HDOD domain; Region: HDOD; pfam08668
261292005350	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
261292005351	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
261292005352	metal binding site [ion binding]; metal-binding site
261292005353	active site
261292005354	I-site; other site
261292005355	multifunctional aminopeptidase A; Provisional; Region: PRK00913
261292005356	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
261292005357	interface (dimer of trimers) [polypeptide binding]; other site
261292005358	Substrate-binding/catalytic site; other site
261292005359	Zn-binding sites [ion binding]; other site
261292005360	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
261292005361	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
261292005362	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
261292005363	HIGH motif; other site
261292005364	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
261292005365	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
261292005366	active site
261292005367	KMSKS motif; other site
261292005368	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
261292005369	tRNA binding surface [nucleotide binding]; other site
261292005370	anticodon binding site; other site
261292005371	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
261292005372	PEP-CTERM motif; Region: VPEP; pfam07589
261292005373	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
261292005374	active site
261292005375	DNA binding site [nucleotide binding]
261292005376	Int/Topo IB signature motif; other site
261292005377	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
261292005378	Helix-turn-helix domain; Region: HTH_28; pfam13518
261292005379	Winged helix-turn helix; Region: HTH_29; pfam13551
261292005380	Winged helix-turn helix; Region: HTH_33; pfam13592
261292005381	DDE superfamily endonuclease; Region: DDE_3; pfam13358
261292005382	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
261292005383	Protein of unknown function (DUF3631); Region: DUF3631; pfam12307
261292005384	RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248
261292005385	ATP binding site [chemical binding]; other site
261292005386	GAF domain; Region: GAF; cl17456
261292005387	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
261292005388	Zn2+ binding site [ion binding]; other site
261292005389	Mg2+ binding site [ion binding]; other site
261292005390	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
261292005391	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
261292005392	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
261292005393	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
261292005394	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
261292005395	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
261292005396	Tetramer interface [polypeptide binding]; other site
261292005397	active site
261292005398	FMN-binding site [chemical binding]; other site
261292005399	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
261292005400	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
261292005401	Transposase [DNA replication, recombination, and repair]; Region: COG5433
261292005402	Transposase [DNA replication, recombination, and repair]; Region: COG5433
261292005403	Poxvirus I6-like family; Region: Pox_I6; cl17808
261292005404	flagellar motor protein MotB; Validated; Region: motB; PRK05996
261292005405	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
261292005406	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
261292005407	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
261292005408	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
261292005409	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
261292005410	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
261292005411	acetyl-CoA synthetase; Provisional; Region: PRK00174
261292005412	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
261292005413	active site
261292005414	CoA binding site [chemical binding]; other site
261292005415	acyl-activating enzyme (AAE) consensus motif; other site
261292005416	AMP binding site [chemical binding]; other site
261292005417	acetate binding site [chemical binding]; other site
261292005418	ribosome maturation protein RimP; Reviewed; Region: PRK00092
261292005419	Sm and related proteins; Region: Sm_like; cl00259
261292005420	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
261292005421	putative oligomer interface [polypeptide binding]; other site
261292005422	putative RNA binding site [nucleotide binding]; other site
261292005423	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
261292005424	NusA N-terminal domain; Region: NusA_N; pfam08529
261292005425	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
261292005426	RNA binding site [nucleotide binding]; other site
261292005427	homodimer interface [polypeptide binding]; other site
261292005428	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
261292005429	G-X-X-G motif; other site
261292005430	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
261292005431	G-X-X-G motif; other site
261292005432	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
261292005433	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
261292005434	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
261292005435	translation initiation factor IF-2; Validated; Region: infB; PRK05306
261292005436	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
261292005437	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
261292005438	G1 box; other site
261292005439	putative GEF interaction site [polypeptide binding]; other site
261292005440	GTP/Mg2+ binding site [chemical binding]; other site
261292005441	Switch I region; other site
261292005442	G2 box; other site
261292005443	G3 box; other site
261292005444	Switch II region; other site
261292005445	G4 box; other site
261292005446	G5 box; other site
261292005447	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
261292005448	Translation-initiation factor 2; Region: IF-2; pfam11987
261292005449	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
261292005450	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
261292005451	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851
261292005452	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
261292005453	RNA binding site [nucleotide binding]; other site
261292005454	active site
261292005455	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
261292005456	Protein of unknown function, DUF486; Region: DUF486; pfam04342
261292005457	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
261292005458	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
261292005459	UbiA prenyltransferase family; Region: UbiA; pfam01040
261292005460	Chorismate lyase; Region: Chor_lyase; cl01230
261292005461	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
261292005462	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
261292005463	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
261292005464	generic binding surface II; other site
261292005465	ssDNA binding site; other site
261292005466	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
261292005467	ATP binding site [chemical binding]; other site
261292005468	putative Mg++ binding site [ion binding]; other site
261292005469	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
261292005470	nucleotide binding region [chemical binding]; other site
261292005471	ATP-binding site [chemical binding]; other site
261292005472	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
261292005473	homotrimer interaction site [polypeptide binding]; other site
261292005474	putative active site [active]
261292005475	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
261292005476	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
261292005477	hinge; other site
261292005478	active site
261292005479	argininosuccinate lyase; Provisional; Region: PRK00855
261292005480	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
261292005481	active sites [active]
261292005482	tetramer interface [polypeptide binding]; other site
261292005483	Phosphotransferase enzyme family; Region: APH; pfam01636
261292005484	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
261292005485	active site
261292005486	ATP binding site [chemical binding]; other site
261292005487	CTP synthetase; Validated; Region: pyrG; PRK05380
261292005488	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
261292005489	Catalytic site [active]
261292005490	active site
261292005491	UTP binding site [chemical binding]; other site
261292005492	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
261292005493	active site
261292005494	putative oxyanion hole; other site
261292005495	catalytic triad [active]
261292005496	enolase; Provisional; Region: eno; PRK00077
261292005497	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
261292005498	dimer interface [polypeptide binding]; other site
261292005499	metal binding site [ion binding]; metal-binding site
261292005500	substrate binding pocket [chemical binding]; other site
261292005501	Septum formation initiator; Region: DivIC; cl17659
261292005502	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
261292005503	heat shock protein HtpX; Provisional; Region: PRK05457
261292005504	putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073
261292005505	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292005506	active site
261292005507	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
261292005508	phosphorylation site [posttranslational modification]
261292005509	intermolecular recognition site; other site
261292005510	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292005511	active site
261292005512	phosphorylation site [posttranslational modification]
261292005513	intermolecular recognition site; other site
261292005514	dimerization interface [polypeptide binding]; other site
261292005515	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
261292005516	metal binding site [ion binding]; metal-binding site
261292005517	active site
261292005518	I-site; other site
261292005519	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986
261292005520	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
261292005521	putative acyl-acceptor binding pocket; other site
261292005522	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
261292005523	YcfA-like protein; Region: YcfA; pfam07927
261292005524	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
261292005525	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
261292005526	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
261292005527	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_7; cd03862
261292005528	putative active site [active]
261292005529	Zn binding site [ion binding]; other site
261292005530	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
261292005531	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
261292005532	putative active site [active]
261292005533	putative metal binding site [ion binding]; other site
261292005534	Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199
261292005535	active site
261292005536	nucleophile elbow; other site
261292005537	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
261292005538	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
261292005539	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
261292005540	Sulfatase; Region: Sulfatase; cl17466
261292005541	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
261292005542	outer membrane lipoprotein Blc; Provisional; Region: PRK10477
261292005543	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
261292005544	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
261292005545	fumarate hydratase; Reviewed; Region: fumC; PRK00485
261292005546	Class II fumarases; Region: Fumarase_classII; cd01362
261292005547	active site
261292005548	tetramer interface [polypeptide binding]; other site
261292005549	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
261292005550	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
261292005551	non-specific DNA binding site [nucleotide binding]; other site
261292005552	salt bridge; other site
261292005553	sequence-specific DNA binding site [nucleotide binding]; other site
261292005554	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
261292005555	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
261292005556	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
261292005557	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
261292005558	dimer interface [polypeptide binding]; other site
261292005559	putative radical transfer pathway; other site
261292005560	diiron center [ion binding]; other site
261292005561	tyrosyl radical; other site
261292005562	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
261292005563	ATP cone domain; Region: ATP-cone; pfam03477
261292005564	Class I ribonucleotide reductase; Region: RNR_I; cd01679
261292005565	active site
261292005566	dimer interface [polypeptide binding]; other site
261292005567	catalytic residues [active]
261292005568	effector binding site; other site
261292005569	R2 peptide binding site; other site
261292005570	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
261292005571	active site
261292005572	zinc binding site [ion binding]; other site
261292005573	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
261292005574	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
261292005575	dimer interface [polypeptide binding]; other site
261292005576	active site
261292005577	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
261292005578	catalytic residues [active]
261292005579	substrate binding site [chemical binding]; other site
261292005580	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
261292005581	PLD-like domain; Region: PLDc_2; pfam13091
261292005582	putative active site [active]
261292005583	catalytic site [active]
261292005584	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
261292005585	PLD-like domain; Region: PLDc_2; pfam13091
261292005586	putative active site [active]
261292005587	catalytic site [active]
261292005588	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
261292005589	PAS domain S-box; Region: sensory_box; TIGR00229
261292005590	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292005591	putative active site [active]
261292005592	heme pocket [chemical binding]; other site
261292005593	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
261292005594	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
261292005595	metal binding site [ion binding]; metal-binding site
261292005596	active site
261292005597	I-site; other site
261292005598	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
261292005599	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
261292005600	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
261292005601	Walker A/P-loop; other site
261292005602	ATP binding site [chemical binding]; other site
261292005603	Q-loop/lid; other site
261292005604	Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338
261292005605	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
261292005606	active site
261292005607	zinc binding site [ion binding]; other site
261292005608	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
261292005609	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
261292005610	Coenzyme A binding pocket [chemical binding]; other site
261292005611	Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247
261292005612	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
261292005613	EamA-like transporter family; Region: EamA; pfam00892
261292005614	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
261292005615	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
261292005616	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
261292005617	[2Fe-2S] cluster binding site [ion binding]; other site
261292005618	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
261292005619	alpha subunit interface [polypeptide binding]; other site
261292005620	active site
261292005621	substrate binding site [chemical binding]; other site
261292005622	Fe binding site [ion binding]; other site
261292005623	primosome assembly protein PriA; Validated; Region: PRK05580
261292005624	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
261292005625	ATP binding site [chemical binding]; other site
261292005626	putative Mg++ binding site [ion binding]; other site
261292005627	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
261292005628	Protein of unknown function (DUF465); Region: DUF465; cl01070
261292005629	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
261292005630	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
261292005631	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
261292005632	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
261292005633	GIY-YIG motif/motif A; other site
261292005634	active site
261292005635	catalytic site [active]
261292005636	putative DNA binding site [nucleotide binding]; other site
261292005637	metal binding site [ion binding]; metal-binding site
261292005638	UvrB/uvrC motif; Region: UVR; pfam02151
261292005639	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
261292005640	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
261292005641	active site 1 [active]
261292005642	dimer interface [polypeptide binding]; other site
261292005643	hexamer interface [polypeptide binding]; other site
261292005644	active site 2 [active]
261292005645	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
261292005646	Fe-S cluster binding site [ion binding]; other site
261292005647	DNA binding site [nucleotide binding]
261292005648	active site
261292005649	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
261292005650	Surface antigen; Region: Bac_surface_Ag; pfam01103
261292005651	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
261292005652	Family of unknown function (DUF490); Region: DUF490; pfam04357
261292005653	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
261292005654	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
261292005655	non-specific DNA binding site [nucleotide binding]; other site
261292005656	salt bridge; other site
261292005657	sequence-specific DNA binding site [nucleotide binding]; other site
261292005658	GTP-binding protein Der; Reviewed; Region: PRK00093
261292005659	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
261292005660	G1 box; other site
261292005661	GTP/Mg2+ binding site [chemical binding]; other site
261292005662	Switch I region; other site
261292005663	G2 box; other site
261292005664	Switch II region; other site
261292005665	G3 box; other site
261292005666	G4 box; other site
261292005667	G5 box; other site
261292005668	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
261292005669	G1 box; other site
261292005670	GTP/Mg2+ binding site [chemical binding]; other site
261292005671	Switch I region; other site
261292005672	G2 box; other site
261292005673	G3 box; other site
261292005674	Switch II region; other site
261292005675	G4 box; other site
261292005676	G5 box; other site
261292005677	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
261292005678	PQQ-like domain; Region: PQQ_2; pfam13360
261292005679	Trp docking motif [polypeptide binding]; other site
261292005680	active site
261292005681	PQQ-like domain; Region: PQQ_2; pfam13360
261292005682	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
261292005683	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
261292005684	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
261292005685	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
261292005686	dimer interface [polypeptide binding]; other site
261292005687	motif 1; other site
261292005688	active site
261292005689	motif 2; other site
261292005690	motif 3; other site
261292005691	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
261292005692	anticodon binding site; other site
261292005693	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
261292005694	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
261292005695	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
261292005696	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
261292005697	non-specific DNA binding site [nucleotide binding]; other site
261292005698	salt bridge; other site
261292005699	sequence-specific DNA binding site [nucleotide binding]; other site
261292005700	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
261292005701	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
261292005702	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
261292005703	binding surface
261292005704	TPR motif; other site
261292005705	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
261292005706	binding surface
261292005707	TPR motif; other site
261292005708	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
261292005709	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
261292005710	FeS/SAM binding site; other site
261292005711	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
261292005712	active site
261292005713	multimer interface [polypeptide binding]; other site
261292005714	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
261292005715	active site residue [active]
261292005716	Protein of unknown function (DUF3025); Region: DUF3025; pfam11227
261292005717	Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264
261292005718	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
261292005719	FlgN protein; Region: FlgN; pfam05130
261292005720	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
261292005721	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
261292005722	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
261292005723	ligand binding site [chemical binding]; other site
261292005724	flagellar motor protein; Reviewed; Region: motC; PRK09109
261292005725	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
261292005726	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
261292005727	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
261292005728	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
261292005729	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
261292005730	DNA binding residues [nucleotide binding]
261292005731	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
261292005732	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
261292005733	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
261292005734	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK06995
261292005735	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
261292005736	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
261292005737	FHIPEP family; Region: FHIPEP; pfam00771
261292005738	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
261292005739	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
261292005740	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
261292005741	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
261292005742	active site
261292005743	exopolysaccharide biosynthesis operon protein EpsL; Region: EpsL; TIGR03014
261292005744	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
261292005745	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
261292005746	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
261292005747	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
261292005748	Repair protein; Region: Repair_PSII; pfam04536
261292005749	Repair protein; Region: Repair_PSII; pfam04536
261292005750	Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066
261292005751	nickel binding site [ion binding]; other site
261292005752	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
261292005753	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
261292005754	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
261292005755	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
261292005756	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
261292005757	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
261292005758	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
261292005759	dimerization interface [polypeptide binding]; other site
261292005760	domain crossover interface; other site
261292005761	redox-dependent activation switch; other site
261292005762	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
261292005763	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292005764	active site
261292005765	phosphorylation site [posttranslational modification]
261292005766	intermolecular recognition site; other site
261292005767	dimerization interface [polypeptide binding]; other site
261292005768	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
261292005769	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292005770	ATP binding site [chemical binding]; other site
261292005771	Mg2+ binding site [ion binding]; other site
261292005772	G-X-G motif; other site
261292005773	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
261292005774	Competence protein; Region: Competence; pfam03772
261292005775	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
261292005776	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
261292005777	CheB methylesterase; Region: CheB_methylest; pfam01339
261292005778	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
261292005779	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
261292005780	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
261292005781	Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473
261292005782	PAS domain; Region: PAS_10; pfam13596
261292005783	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292005784	putative active site [active]
261292005785	heme pocket [chemical binding]; other site
261292005786	PAS domain; Region: PAS; smart00091
261292005787	PAS domain; Region: PAS_9; pfam13426
261292005788	Histidine kinase; Region: HisKA_3; pfam07730
261292005789	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292005790	ATP binding site [chemical binding]; other site
261292005791	Mg2+ binding site [ion binding]; other site
261292005792	G-X-G motif; other site
261292005793	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
261292005794	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292005795	active site
261292005796	phosphorylation site [posttranslational modification]
261292005797	intermolecular recognition site; other site
261292005798	dimerization interface [polypeptide binding]; other site
261292005799	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
261292005800	DNA binding residues [nucleotide binding]
261292005801	dimerization interface [polypeptide binding]; other site
261292005802	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
261292005803	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
261292005804	putative active site; other site
261292005805	catalytic residue [active]
261292005806	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
261292005807	Sel1-like repeats; Region: SEL1; smart00671
261292005808	Sel1-like repeats; Region: SEL1; smart00671
261292005809	Sel1-like repeats; Region: SEL1; smart00671
261292005810	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
261292005811	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
261292005812	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
261292005813	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
261292005814	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
261292005815	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
261292005816	tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415
261292005817	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
261292005818	FMN binding site [chemical binding]; other site
261292005819	active site
261292005820	catalytic residues [active]
261292005821	substrate binding site [chemical binding]; other site
261292005822	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
261292005823	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
261292005824	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
261292005825	purine monophosphate binding site [chemical binding]; other site
261292005826	dimer interface [polypeptide binding]; other site
261292005827	putative catalytic residues [active]
261292005828	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
261292005829	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
261292005830	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
261292005831	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
261292005832	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
261292005833	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
261292005834	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870
261292005835	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
261292005836	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945
261292005837	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
261292005838	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
261292005839	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
261292005840	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
261292005841	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
261292005842	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
261292005843	Flagellar L-ring protein; Region: FlgH; cl17277
261292005844	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
261292005845	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
261292005846	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
261292005847	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
261292005848	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
261292005849	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
261292005850	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
261292005851	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
261292005852	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
261292005853	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
261292005854	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
261292005855	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
261292005856	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
261292005857	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
261292005858	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
261292005859	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
261292005860	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
261292005861	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
261292005862	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018
261292005863	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
261292005864	acyl carrier protein; Provisional; Region: PRK07639
261292005865	Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560
261292005866	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
261292005867	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
261292005868	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
261292005869	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
261292005870	active site
261292005871	Zn binding site [ion binding]; other site
261292005872	Predicted membrane protein [Function unknown]; Region: COG1981
261292005873	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
261292005874	non-specific DNA binding site [nucleotide binding]; other site
261292005875	salt bridge; other site
261292005876	sequence-specific DNA binding site [nucleotide binding]; other site
261292005877	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
261292005878	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
261292005879	active site
261292005880	catalytic residues [active]
261292005881	metal binding site [ion binding]; metal-binding site
261292005882	5'-methylthioadenosine phosphorylase; Validated; Region: PRK09136
261292005883	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
261292005884	active site
261292005885	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
261292005886	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
261292005887	nucleotide binding pocket [chemical binding]; other site
261292005888	K-X-D-G motif; other site
261292005889	catalytic site [active]
261292005890	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
261292005891	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
261292005892	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
261292005893	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
261292005894	Dimer interface [polypeptide binding]; other site
261292005895	BRCT sequence motif; other site
261292005896	Protein of unknown function (DUF2914); Region: DUF2914; pfam11141
261292005897	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
261292005898	nudix motif; other site
261292005899	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
261292005900	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
261292005901	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
261292005902	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
261292005903	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
261292005904	homodimer interface [polypeptide binding]; other site
261292005905	substrate-cofactor binding pocket; other site
261292005906	pyridoxal 5'-phosphate binding site [chemical binding]; other site
261292005907	catalytic residue [active]
261292005908	Protein of unknown function (DUF493); Region: DUF493; pfam04359
261292005909	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
261292005910	lipoyl synthase; Provisional; Region: PRK05481
261292005911	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
261292005912	FeS/SAM binding site; other site
261292005913	OsmC-like protein; Region: OsmC; cl00767
261292005914	Cytochrome c; Region: Cytochrom_C; cl11414
261292005915	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
261292005916	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
261292005917	Transposase domain (DUF772); Region: DUF772; pfam05598
261292005918	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
261292005919	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
261292005920	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
261292005921	PAS domain; Region: PAS_8; pfam13188
261292005922	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
261292005923	dimer interface [polypeptide binding]; other site
261292005924	phosphorylation site [posttranslational modification]
261292005925	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292005926	ATP binding site [chemical binding]; other site
261292005927	Mg2+ binding site [ion binding]; other site
261292005928	G-X-G motif; other site
261292005929	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
261292005930	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292005931	active site
261292005932	phosphorylation site [posttranslational modification]
261292005933	intermolecular recognition site; other site
261292005934	dimerization interface [polypeptide binding]; other site
261292005935	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
261292005936	DNA binding site [nucleotide binding]
261292005937	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
261292005938	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
261292005939	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
261292005940	S-adenosylmethionine binding site [chemical binding]; other site
261292005941	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
261292005942	HlyD family secretion protein; Region: HlyD_3; pfam13437
261292005943	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
261292005944	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
261292005945	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
261292005946	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
261292005947	nudix motif; other site
261292005948	Predicted integral membrane protein [Function unknown]; Region: COG5617
261292005949	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
261292005950	dimer interface [polypeptide binding]; other site
261292005951	phosphorylation site [posttranslational modification]
261292005952	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292005953	ATP binding site [chemical binding]; other site
261292005954	Mg2+ binding site [ion binding]; other site
261292005955	G-X-G motif; other site
261292005956	Response regulator receiver domain; Region: Response_reg; pfam00072
261292005957	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292005958	active site
261292005959	phosphorylation site [posttranslational modification]
261292005960	intermolecular recognition site; other site
261292005961	dimerization interface [polypeptide binding]; other site
261292005962	Transposase, Mutator family; Region: Transposase_mut; pfam00872
261292005963	Protein of unknown function (DUF987); Region: DUF987; pfam06174
261292005964	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
261292005965	Cytochrome c; Region: Cytochrom_C; cl11414
261292005966	Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152
261292005967	putative heme binding pocket [chemical binding]; other site
261292005968	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
261292005969	Serine hydrolase; Region: Ser_hydrolase; cl17834
261292005970	Protein of unknown function (DUF3616); Region: DUF3616; pfam12275
261292005971	PemK-like protein; Region: PemK; pfam02452
261292005972	SEC-C motif; Region: SEC-C; pfam02810
261292005973	Transposase domain (DUF772); Region: DUF772; pfam05598
261292005974	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
261292005975	DDE superfamily endonuclease; Region: DDE_4; cl17710
261292005976	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
261292005977	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
261292005978	oligomer interface [polypeptide binding]; other site
261292005979	metal binding site [ion binding]; metal-binding site
261292005980	metal binding site [ion binding]; metal-binding site
261292005981	putative Cl binding site [ion binding]; other site
261292005982	basic sphincter; other site
261292005983	hydrophobic gate; other site
261292005984	periplasmic entrance; other site
261292005985	Transposase; Region: HTH_Tnp_1; pfam01527
261292005986	putative transposase OrfB; Reviewed; Region: PHA02517
261292005987	HTH-like domain; Region: HTH_21; pfam13276
261292005988	Integrase core domain; Region: rve; pfam00665
261292005989	Integrase core domain; Region: rve_3; cl15866
261292005990	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
261292005991	Domain of unknown function DUF20; Region: UPF0118; pfam01594
261292005992	Transposase domain (DUF772); Region: DUF772; pfam05598
261292005993	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
261292005994	DDE superfamily endonuclease; Region: DDE_4; cl17710
261292005995	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
261292005996	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
261292005997	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
261292005998	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
261292005999	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
261292006000	putative transposase OrfB; Reviewed; Region: PHA02517
261292006001	HTH-like domain; Region: HTH_21; pfam13276
261292006002	Integrase core domain; Region: rve; pfam00665
261292006003	Integrase core domain; Region: rve_3; cl15866
261292006004	Transposase; Region: HTH_Tnp_1; pfam01527
261292006005	Transposase domain (DUF772); Region: DUF772; pfam05598
261292006006	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
261292006007	DDE superfamily endonuclease; Region: DDE_4; cl17710
261292006008	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
261292006009	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
261292006010	active site
261292006011	DNA binding site [nucleotide binding]
261292006012	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
261292006013	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
261292006014	active site
261292006015	catalytic site [active]
261292006016	substrate binding site [chemical binding]; other site
261292006017	nucleotide excision repair endonuclease; Provisional; Region: PRK10545
261292006018	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
261292006019	GIY-YIG motif/motif A; other site
261292006020	active site
261292006021	catalytic site [active]
261292006022	putative DNA binding site [nucleotide binding]; other site
261292006023	metal binding site [ion binding]; metal-binding site
261292006024	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
261292006025	Catalytic site [active]
261292006026	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
261292006027	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
261292006028	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
261292006029	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
261292006030	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
261292006031	CsbD-like; Region: CsbD; pfam05532
261292006032	Hemerythrin-like domain; Region: Hr-like; cd12108
261292006033	Fe binding site [ion binding]; other site
261292006034	putative transposase OrfB; Reviewed; Region: PHA02517
261292006035	HTH-like domain; Region: HTH_21; pfam13276
261292006036	Integrase core domain; Region: rve; pfam00665
261292006037	Integrase core domain; Region: rve_3; pfam13683
261292006038	Protein of unknown function (DUF3616); Region: DUF3616; pfam12275
261292006039	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
261292006040	active site
261292006041	DNA binding site [nucleotide binding]
261292006042	Int/Topo IB signature motif; other site
261292006043	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
261292006044	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
261292006045	salt bridge; other site
261292006046	non-specific DNA binding site [nucleotide binding]; other site
261292006047	sequence-specific DNA binding site [nucleotide binding]; other site
261292006048	hypothetical protein; Provisional; Region: PRK10396
261292006049	yecA family protein; Region: ygfB_yecA; TIGR02292
261292006050	Helix-turn-helix domain; Region: HTH_17; pfam12728
261292006051	Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840
261292006052	integrase; Provisional; Region: PRK09692
261292006053	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
261292006054	active site
261292006055	Int/Topo IB signature motif; other site
261292006056	PAS domain; Region: PAS_9; pfam13426
261292006057	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292006058	putative active site [active]
261292006059	heme pocket [chemical binding]; other site
261292006060	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
261292006061	hydrophobic ligand binding site; other site
261292006062	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
261292006063	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
261292006064	Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008
261292006065	glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838
261292006066	active site
261292006067	HIGH motif; other site
261292006068	nucleotide binding site [chemical binding]; other site
261292006069	active site
261292006070	KMSKS motif; other site
261292006071	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
261292006072	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
261292006073	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
261292006074	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
261292006075	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
261292006076	active site
261292006077	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
261292006078	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
261292006079	Multicopper oxidase; Region: Cu-oxidase; pfam00394
261292006080	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
261292006081	putative cation:proton antiport protein; Provisional; Region: PRK10669
261292006082	TrkA-N domain; Region: TrkA_N; pfam02254
261292006083	TrkA-C domain; Region: TrkA_C; pfam02080
261292006084	Glutamate-cysteine ligase; Region: GshA; pfam08886
261292006085	glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049
261292006086	glutathione synthetase; Provisional; Region: PRK05246
261292006087	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
261292006088	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
261292006089	FtsH Extracellular; Region: FtsH_ext; pfam06480
261292006090	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
261292006091	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
261292006092	Walker A motif; other site
261292006093	ATP binding site [chemical binding]; other site
261292006094	Walker B motif; other site
261292006095	arginine finger; other site
261292006096	Peptidase family M41; Region: Peptidase_M41; pfam01434
261292006097	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
261292006098	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
261292006099	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292006100	PAS domain; Region: PAS_9; pfam13426
261292006101	putative active site [active]
261292006102	heme pocket [chemical binding]; other site
261292006103	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
261292006104	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
261292006105	metal binding site [ion binding]; metal-binding site
261292006106	active site
261292006107	I-site; other site
261292006108	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
261292006109	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
261292006110	putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350
261292006111	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
261292006112	pyridoxal 5'-phosphate binding site [chemical binding]; other site
261292006113	homodimer interface [polypeptide binding]; other site
261292006114	catalytic residue [active]
261292006115	5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344
261292006116	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
261292006117	Methyltransferase domain; Region: Methyltransf_31; pfam13847
261292006118	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
261292006119	S-adenosylmethionine binding site [chemical binding]; other site
261292006120	Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492
261292006121	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
261292006122	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
261292006123	Probable Catalytic site; other site
261292006124	Methyltransferase domain; Region: Methyltransf_31; pfam13847
261292006125	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
261292006126	S-adenosylmethionine binding site [chemical binding]; other site
261292006127	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
261292006128	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
261292006129	FeS/SAM binding site; other site
261292006130	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
261292006131	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
261292006132	mercuric reductase; Validated; Region: PRK06370
261292006133	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
261292006134	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
261292006135	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
261292006136	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
261292006137	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
261292006138	putative active site [active]
261292006139	putative metal binding site [ion binding]; other site
261292006140	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
261292006141	AAA domain; Region: AAA_22; pfam13401
261292006142	YcfA-like protein; Region: YcfA; pfam07927
261292006143	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
261292006144	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
261292006145	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
261292006146	heme binding site [chemical binding]; other site
261292006147	ferroxidase pore; other site
261292006148	ferroxidase diiron center [ion binding]; other site
261292006149	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
261292006150	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
261292006151	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
261292006152	catalytic residue [active]
261292006153	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
261292006154	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
261292006155	NAD(P) binding site [chemical binding]; other site
261292006156	active site
261292006157	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599
261292006158	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
261292006159	active site
261292006160	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
261292006161	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
261292006162	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
261292006163	ATP binding site [chemical binding]; other site
261292006164	putative Mg++ binding site [ion binding]; other site
261292006165	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
261292006166	nucleotide binding region [chemical binding]; other site
261292006167	ATP-binding site [chemical binding]; other site
261292006168	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
261292006169	HRDC domain; Region: HRDC; pfam00570
261292006170	glutamine synthetase; Provisional; Region: glnA; PRK09469
261292006171	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
261292006172	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
261292006173	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
261292006174	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
261292006175	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
261292006176	putative catalytic site [active]
261292006177	putative phosphate binding site [ion binding]; other site
261292006178	active site
261292006179	metal binding site A [ion binding]; metal-binding site
261292006180	DNA binding site [nucleotide binding]
261292006181	putative AP binding site [nucleotide binding]; other site
261292006182	putative metal binding site B [ion binding]; other site
261292006183	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
261292006184	DEAD/DEAH box helicase; Region: DEAD; pfam00270
261292006185	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
261292006186	hypothetical protein; Validated; Region: PRK01777
261292006187	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
261292006188	putative coenzyme Q binding site [chemical binding]; other site
261292006189	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
261292006190	SmpB-tmRNA interface; other site
261292006191	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
261292006192	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
261292006193	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
261292006194	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292006195	active site
261292006196	phosphorylation site [posttranslational modification]
261292006197	intermolecular recognition site; other site
261292006198	dimerization interface [polypeptide binding]; other site
261292006199	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
261292006200	Walker A motif; other site
261292006201	ATP binding site [chemical binding]; other site
261292006202	Walker B motif; other site
261292006203	arginine finger; other site
261292006204	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
261292006205	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
261292006206	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
261292006207	dimer interface [polypeptide binding]; other site
261292006208	phosphorylation site [posttranslational modification]
261292006209	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292006210	ATP binding site [chemical binding]; other site
261292006211	Mg2+ binding site [ion binding]; other site
261292006212	G-X-G motif; other site
261292006213	Domain of unknown function (DUF4366); Region: DUF4366; pfam14283
261292006214	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
261292006215	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
261292006216	substrate binding pocket [chemical binding]; other site
261292006217	chain length determination region; other site
261292006218	substrate-Mg2+ binding site; other site
261292006219	catalytic residues [active]
261292006220	aspartate-rich region 1; other site
261292006221	active site lid residues [active]
261292006222	aspartate-rich region 2; other site
261292006223	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
261292006224	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
261292006225	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
261292006226	Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729
261292006227	GTP1/OBG; Region: GTP1_OBG; pfam01018
261292006228	Obg GTPase; Region: Obg; cd01898
261292006229	G1 box; other site
261292006230	GTP/Mg2+ binding site [chemical binding]; other site
261292006231	Switch I region; other site
261292006232	G2 box; other site
261292006233	G3 box; other site
261292006234	Switch II region; other site
261292006235	G4 box; other site
261292006236	G5 box; other site
261292006237	gamma-glutamyl kinase; Provisional; Region: PRK05429
261292006238	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
261292006239	nucleotide binding site [chemical binding]; other site
261292006240	homotetrameric interface [polypeptide binding]; other site
261292006241	putative phosphate binding site [ion binding]; other site
261292006242	putative allosteric binding site; other site
261292006243	PUA domain; Region: PUA; pfam01472
261292006244	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
261292006245	NAD synthetase; Reviewed; Region: nadE; PRK02628
261292006246	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
261292006247	multimer interface [polypeptide binding]; other site
261292006248	active site
261292006249	catalytic triad [active]
261292006250	protein interface 1 [polypeptide binding]; other site
261292006251	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
261292006252	homodimer interface [polypeptide binding]; other site
261292006253	NAD binding pocket [chemical binding]; other site
261292006254	ATP binding pocket [chemical binding]; other site
261292006255	Mg binding site [ion binding]; other site
261292006256	active-site loop [active]
261292006257	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
261292006258	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
261292006259	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
261292006260	Phage related hypothetical protein (DUF1799); Region: DUF1799; pfam08809
261292006261	Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124
261292006262	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
261292006263	phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215
261292006264	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
261292006265	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
261292006266	oligomerization interface [polypeptide binding]; other site
261292006267	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
261292006268	Phage capsid family; Region: Phage_capsid; pfam05065
261292006269	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
261292006270	Phage portal protein; Region: Phage_portal; pfam04860
261292006271	Phage-related protein [Function unknown]; Region: COG4695
261292006272	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
261292006273	Phage terminase, small subunit; Region: Terminase_4; pfam05119
261292006274	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
261292006275	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
261292006276	active site
261292006277	Virulence-associated protein E; Region: VirE; pfam05272
261292006278	Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197
261292006279	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
261292006280	non-specific DNA binding site [nucleotide binding]; other site
261292006281	salt bridge; other site
261292006282	sequence-specific DNA binding site [nucleotide binding]; other site
261292006283	Staphylococcal nuclease homologues; Region: SNc; smart00318
261292006284	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
261292006285	Catalytic site; other site
261292006286	Uncharacterized conserved protein (DUF2303); Region: DUF2303; cl02338
261292006287	deoxynucleoside monophosphate kinase; Provisional; Region: 1; PHA02575
261292006288	AntA/AntB antirepressor; Region: AntA; pfam08346
261292006289	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
261292006290	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
261292006291	dimer interface [polypeptide binding]; other site
261292006292	ssDNA binding site [nucleotide binding]; other site
261292006293	tetramer (dimer of dimers) interface [polypeptide binding]; other site
261292006294	Domain of unknown function (DUF4224); Region: DUF4224; pfam13986
261292006295	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
261292006296	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
261292006297	active site
261292006298	DNA binding site [nucleotide binding]
261292006299	Int/Topo IB signature motif; other site
261292006300	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
261292006301	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
261292006302	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
261292006303	PA/protease or protease-like domain interface [polypeptide binding]; other site
261292006304	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
261292006305	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
261292006306	ligand binding site [chemical binding]; other site
261292006307	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
261292006308	AAA ATPase domain; Region: AAA_16; pfam13191
261292006309	PEP-CTERM motif; Region: VPEP; pfam07589
261292006310	Protein of unknown function (DUF2798); Region: DUF2798; pfam11391
261292006311	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
261292006312	nucleoside/Zn binding site; other site
261292006313	dimer interface [polypeptide binding]; other site
261292006314	catalytic motif [active]
261292006315	putative cation:proton antiport protein; Provisional; Region: PRK10669
261292006316	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
261292006317	TrkA-N domain; Region: TrkA_N; pfam02254
261292006318	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
261292006319	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
261292006320	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
261292006321	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
261292006322	Walker A/P-loop; other site
261292006323	ATP binding site [chemical binding]; other site
261292006324	Q-loop/lid; other site
261292006325	ABC transporter signature motif; other site
261292006326	Walker B; other site
261292006327	D-loop; other site
261292006328	H-loop/switch region; other site
261292006329	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
261292006330	flagellar motor protein MotA; Validated; Region: PRK09110
261292006331	flagellar motor protein MotB; Validated; Region: motB; PRK09041
261292006332	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
261292006333	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
261292006334	ligand binding site [chemical binding]; other site
261292006335	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
261292006336	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
261292006337	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
261292006338	active site
261292006339	HIGH motif; other site
261292006340	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
261292006341	KMSKS motif; other site
261292006342	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
261292006343	tRNA binding surface [nucleotide binding]; other site
261292006344	anticodon binding site; other site
261292006345	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
261292006346	substrate binding site [chemical binding]; other site
261292006347	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
261292006348	substrate binding site [chemical binding]; other site
261292006349	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
261292006350	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
261292006351	homodimer interface [polypeptide binding]; other site
261292006352	substrate-cofactor binding pocket; other site
261292006353	pyridoxal 5'-phosphate binding site [chemical binding]; other site
261292006354	catalytic residue [active]
261292006355	amidophosphoribosyltransferase; Provisional; Region: PRK09246
261292006356	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
261292006357	active site
261292006358	tetramer interface [polypeptide binding]; other site
261292006359	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
261292006360	active site
261292006361	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
261292006362	Colicin V production protein; Region: Colicin_V; pfam02674
261292006363	Sporulation related domain; Region: SPOR; pfam05036
261292006364	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
261292006365	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
261292006366	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
261292006367	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
261292006368	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
261292006369	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
261292006370	substrate binding site [chemical binding]; other site
261292006371	active site
261292006372	catalytic residues [active]
261292006373	heterodimer interface [polypeptide binding]; other site
261292006374	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
261292006375	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
261292006376	pyridoxal 5'-phosphate binding site [chemical binding]; other site
261292006377	catalytic residue [active]
261292006378	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
261292006379	active site
261292006380	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
261292006381	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
261292006382	dimerization interface 3.5A [polypeptide binding]; other site
261292006383	active site
261292006384	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
261292006385	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
261292006386	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
261292006387	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
261292006388	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
261292006389	tartrate dehydrogenase; Region: TTC; TIGR02089
261292006390	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
261292006391	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
261292006392	substrate binding site [chemical binding]; other site
261292006393	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
261292006394	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
261292006395	substrate binding site [chemical binding]; other site
261292006396	ligand binding site [chemical binding]; other site
261292006397	phenyl proprionate permease family protein; Region: 2A0127; TIGR00902
261292006398	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
261292006399	putative substrate translocation pore; other site
261292006400	Rubrerythrin [Energy production and conversion]; Region: COG1592
261292006401	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
261292006402	binuclear metal center [ion binding]; other site
261292006403	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
261292006404	Cysteine-rich domain; Region: CCG; pfam02754
261292006405	Protein of unknown function (DUF3501); Region: DUF3501; pfam12007
261292006406	CNP1-like family; Region: CNP1; pfam08750
261292006407	Salmonella virulence plasmid 28.1kDa A protein; Region: VRP1; pfam03538
261292006408	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
261292006409	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
261292006410	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
261292006411	putative active site [active]
261292006412	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
261292006413	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
261292006414	putative transposase OrfB; Reviewed; Region: PHA02517
261292006415	HTH-like domain; Region: HTH_21; pfam13276
261292006416	Integrase core domain; Region: rve; pfam00665
261292006417	Integrase core domain; Region: rve_3; cl15866
261292006418	Transposase; Region: HTH_Tnp_1; pfam01527
261292006419	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
261292006420	Predicted transcriptional regulators [Transcription]; Region: COG1733
261292006421	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
261292006422	GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080
261292006423	putative C-terminal domain interface [polypeptide binding]; other site
261292006424	putative GSH binding site [chemical binding]; other site
261292006425	putative dimer interface [polypeptide binding]; other site
261292006426	C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193
261292006427	putative N-terminal domain interface [polypeptide binding]; other site
261292006428	Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324
261292006429	trehalose synthase; Region: treS_nterm; TIGR02456
261292006430	active site
261292006431	catalytic site [active]
261292006432	sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472
261292006433	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
261292006434	putative ADP-binding pocket [chemical binding]; other site
261292006435	sucrose phosphate synthase, sucrose phosphatase-like domain, bacterial; Region: sucr_syn_bact_C; TIGR02471
261292006436	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
261292006437	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
261292006438	putative substrate binding site [chemical binding]; other site
261292006439	putative ATP binding site [chemical binding]; other site
261292006440	HPP family; Region: HPP; pfam04982
261292006441	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
261292006442	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
261292006443	Transposase; Region: HTH_Tnp_1; pfam01527
261292006444	putative transposase OrfB; Reviewed; Region: PHA02517
261292006445	HTH-like domain; Region: HTH_21; pfam13276
261292006446	Integrase core domain; Region: rve; pfam00665
261292006447	Integrase core domain; Region: rve_2; pfam13333
261292006448	Transposase domain (DUF772); Region: DUF772; pfam05598
261292006449	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
261292006450	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
261292006451	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
261292006452	Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430
261292006453	Domain interface; other site
261292006454	glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535
261292006455	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
261292006456	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
261292006457	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
261292006458	TPP-binding site [chemical binding]; other site
261292006459	dimer interface [polypeptide binding]; other site
261292006460	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
261292006461	PYR/PP interface [polypeptide binding]; other site
261292006462	dimer interface [polypeptide binding]; other site
261292006463	TPP binding site [chemical binding]; other site
261292006464	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
261292006465	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
261292006466	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
261292006467	nucleotide binding site [chemical binding]; other site
261292006468	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
261292006469	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
261292006470	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
261292006471	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
261292006472	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
261292006473	YfdX protein; Region: YfdX; pfam10938
261292006474	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
261292006475	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
261292006476	nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938
261292006477	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292006478	putative active site [active]
261292006479	heme pocket [chemical binding]; other site
261292006480	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292006481	putative active site [active]
261292006482	heme pocket [chemical binding]; other site
261292006483	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
261292006484	dimer interface [polypeptide binding]; other site
261292006485	phosphorylation site [posttranslational modification]
261292006486	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292006487	ATP binding site [chemical binding]; other site
261292006488	Mg2+ binding site [ion binding]; other site
261292006489	G-X-G motif; other site
261292006490	Transposase domain (DUF772); Region: DUF772; pfam05598
261292006491	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
261292006492	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
261292006493	Nitrogen regulatory protein P-II; Region: P-II; cl00412
261292006494	Domain of unknown function (DUF897); Region: DUF897; pfam05982
261292006495	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292006496	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
261292006497	putative active site [active]
261292006498	heme pocket [chemical binding]; other site
261292006499	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292006500	putative active site [active]
261292006501	heme pocket [chemical binding]; other site
261292006502	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
261292006503	dimer interface [polypeptide binding]; other site
261292006504	phosphorylation site [posttranslational modification]
261292006505	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292006506	ATP binding site [chemical binding]; other site
261292006507	Mg2+ binding site [ion binding]; other site
261292006508	G-X-G motif; other site
261292006509	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
261292006510	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292006511	active site
261292006512	phosphorylation site [posttranslational modification]
261292006513	intermolecular recognition site; other site
261292006514	dimerization interface [polypeptide binding]; other site
261292006515	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
261292006516	DNA binding residues [nucleotide binding]
261292006517	dimerization interface [polypeptide binding]; other site
261292006518	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
261292006519	amphipathic channel; other site
261292006520	Asn-Pro-Ala signature motifs; other site
261292006521	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
261292006522	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
261292006523	ATP binding site [chemical binding]; other site
261292006524	putative Mg++ binding site [ion binding]; other site
261292006525	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
261292006526	nucleotide binding region [chemical binding]; other site
261292006527	ATP-binding site [chemical binding]; other site
261292006528	Helicase associated domain (HA2); Region: HA2; pfam04408
261292006529	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
261292006530	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
261292006531	Transposase; Region: DEDD_Tnp_IS110; pfam01548
261292006532	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
261292006533	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
261292006534	Transposase IS200 like; Region: Y1_Tnp; cl00848
261292006535	YcaO domain protein; Region: TIGR03549
261292006536	OsmC-like protein; Region: OsmC; pfam02566
261292006537	YcaO-like family; Region: YcaO; pfam02624
261292006538	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
261292006539	LysR family transcriptional regulator; Provisional; Region: PRK14997
261292006540	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
261292006541	putative effector binding pocket; other site
261292006542	dimerization interface [polypeptide binding]; other site
261292006543	Pirin-related protein [General function prediction only]; Region: COG1741
261292006544	Pirin; Region: Pirin; pfam02678
261292006545	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
261292006546	Predicted membrane protein [Function unknown]; Region: COG2259
261292006547	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
261292006548	Iron-sulfur protein interface; other site
261292006549	proximal quinone binding site [chemical binding]; other site
261292006550	SdhD (CybS) interface [polypeptide binding]; other site
261292006551	proximal heme binding site [chemical binding]; other site
261292006552	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
261292006553	SdhC subunit interface [polypeptide binding]; other site
261292006554	proximal heme binding site [chemical binding]; other site
261292006555	cardiolipin binding site; other site
261292006556	Iron-sulfur protein interface; other site
261292006557	proximal quinone binding site [chemical binding]; other site
261292006558	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057
261292006559	L-aspartate oxidase; Provisional; Region: PRK06175
261292006560	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
261292006561	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
261292006562	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
261292006563	Ligand Binding Site [chemical binding]; other site
261292006564	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
261292006565	Ligand Binding Site [chemical binding]; other site
261292006566	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
261292006567	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
261292006568	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
261292006569	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
261292006570	Soluble P-type ATPase [General function prediction only]; Region: COG4087
261292006571	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
261292006572	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
261292006573	Ligand Binding Site [chemical binding]; other site
261292006574	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
261292006575	Ligand Binding Site [chemical binding]; other site
261292006576	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
261292006577	Staphylococcal nuclease homologues; Region: SNc; smart00318
261292006578	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
261292006579	Catalytic site; other site
261292006580	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
261292006581	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
261292006582	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
261292006583	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
261292006584	Walker A/P-loop; other site
261292006585	ATP binding site [chemical binding]; other site
261292006586	Q-loop/lid; other site
261292006587	ABC transporter signature motif; other site
261292006588	Walker B; other site
261292006589	D-loop; other site
261292006590	H-loop/switch region; other site
261292006591	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
261292006592	Permease; Region: Permease; cl00510
261292006593	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
261292006594	mce related protein; Region: MCE; pfam02470
261292006595	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
261292006596	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
261292006597	anti sigma factor interaction site; other site
261292006598	regulatory phosphorylation site [posttranslational modification]; other site
261292006599	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
261292006600	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
261292006601	Walker A/P-loop; other site
261292006602	ATP binding site [chemical binding]; other site
261292006603	Q-loop/lid; other site
261292006604	ABC transporter signature motif; other site
261292006605	Walker B; other site
261292006606	D-loop; other site
261292006607	H-loop/switch region; other site
261292006608	ABC-2 type transporter; Region: ABC2_membrane; cl17235
261292006609	BolA-like protein; Region: BolA; pfam01722
261292006610	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
261292006611	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
261292006612	putative metal binding site [ion binding]; other site
261292006613	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
261292006614	HSP70 interaction site [polypeptide binding]; other site
261292006615	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
261292006616	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
261292006617	C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196
261292006618	putative N-terminal domain interface [polypeptide binding]; other site
261292006619	putative dimer interface [polypeptide binding]; other site
261292006620	putative substrate binding pocket (H-site) [chemical binding]; other site
261292006621	Transposase; Region: DEDD_Tnp_IS110; pfam01548
261292006622	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
261292006623	SEC-C motif; Region: SEC-C; pfam02810
261292006624	Transposase; Region: DEDD_Tnp_IS110; pfam01548
261292006625	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
261292006626	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
261292006627	Zn binding site [ion binding]; other site
261292006628	Protein of unknown function, DUF399; Region: DUF399; pfam04187
261292006629	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
261292006630	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
261292006631	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
261292006632	dimerization interface [polypeptide binding]; other site
261292006633	ATP binding site [chemical binding]; other site
261292006634	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
261292006635	dimerization interface [polypeptide binding]; other site
261292006636	ATP binding site [chemical binding]; other site
261292006637	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
261292006638	putative active site [active]
261292006639	catalytic triad [active]
261292006640	putative carbohydrate kinase; Provisional; Region: PRK10565
261292006641	Uncharacterized conserved protein [Function unknown]; Region: COG0062
261292006642	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
261292006643	putative substrate binding site [chemical binding]; other site
261292006644	putative ATP binding site [chemical binding]; other site
261292006645	fructokinase; Reviewed; Region: PRK09557
261292006646	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
261292006647	nucleotide binding site [chemical binding]; other site
261292006648	PEP-CTERM motif; Region: VPEP; pfam07589
261292006649	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
261292006650	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
261292006651	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
261292006652	FeS/SAM binding site; other site
261292006653	AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335
261292006654	AMMECR1; Region: AMMECR1; pfam01871
261292006655	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
261292006656	putative ligand binding pocket/active site [active]
261292006657	putative metal binding site [ion binding]; other site
261292006658	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
261292006659	nucleophilic elbow; other site
261292006660	catalytic triad; other site
261292006661	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
261292006662	ApbE family; Region: ApbE; pfam02424
261292006663	Protein of unknown function (DUF3570); Region: DUF3570; pfam12094
261292006664	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
261292006665	Domain of unknown function (DUF4266); Region: DUF4266; pfam14086
261292006666	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
261292006667	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
261292006668	catalytic residues [active]
261292006669	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
261292006670	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
261292006671	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
261292006672	Walker A/P-loop; other site
261292006673	ATP binding site [chemical binding]; other site
261292006674	Q-loop/lid; other site
261292006675	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
261292006676	ABC transporter signature motif; other site
261292006677	Walker B; other site
261292006678	D-loop; other site
261292006679	H-loop/switch region; other site
261292006680	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
261292006681	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
261292006682	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
261292006683	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
261292006684	ferrochelatase; Reviewed; Region: hemH; PRK00035
261292006685	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
261292006686	C-terminal domain interface [polypeptide binding]; other site
261292006687	active site
261292006688	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
261292006689	active site
261292006690	N-terminal domain interface [polypeptide binding]; other site
261292006691	Predicted membrane protein [Function unknown]; Region: COG3212
261292006692	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
261292006693	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
261292006694	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292006695	active site
261292006696	phosphorylation site [posttranslational modification]
261292006697	intermolecular recognition site; other site
261292006698	dimerization interface [polypeptide binding]; other site
261292006699	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
261292006700	DNA binding site [nucleotide binding]
261292006701	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
261292006702	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
261292006703	dimer interface [polypeptide binding]; other site
261292006704	phosphorylation site [posttranslational modification]
261292006705	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292006706	ATP binding site [chemical binding]; other site
261292006707	Mg2+ binding site [ion binding]; other site
261292006708	G-X-G motif; other site
261292006709	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
261292006710	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292006711	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
261292006712	putative active site [active]
261292006713	heme pocket [chemical binding]; other site
261292006714	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292006715	putative active site [active]
261292006716	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
261292006717	heme pocket [chemical binding]; other site
261292006718	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292006719	putative active site [active]
261292006720	heme pocket [chemical binding]; other site
261292006721	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292006722	PAS domain; Region: PAS_9; pfam13426
261292006723	putative active site [active]
261292006724	heme pocket [chemical binding]; other site
261292006725	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
261292006726	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
261292006727	metal binding site [ion binding]; metal-binding site
261292006728	active site
261292006729	I-site; other site
261292006730	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
261292006731	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
261292006732	HsdM N-terminal domain; Region: HsdM_N; pfam12161
261292006733	integrase; Provisional; Region: PRK09692
261292006734	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
261292006735	active site
261292006736	Int/Topo IB signature motif; other site
261292006737	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
261292006738	non-specific DNA binding site [nucleotide binding]; other site
261292006739	salt bridge; other site
261292006740	sequence-specific DNA binding site [nucleotide binding]; other site
261292006741	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
261292006742	Domain of unknown function (DUF927); Region: DUF927; pfam06048
261292006743	ribonuclease R; Region: RNase_R; TIGR02063
261292006744	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
261292006745	RNB domain; Region: RNB; pfam00773
261292006746	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
261292006747	RNA binding site [nucleotide binding]; other site
261292006748	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
261292006749	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
261292006750	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
261292006751	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
261292006752	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
261292006753	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
261292006754	active site
261292006755	HIGH motif; other site
261292006756	nucleotide binding site [chemical binding]; other site
261292006757	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
261292006758	KMSK motif region; other site
261292006759	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
261292006760	tRNA binding surface [nucleotide binding]; other site
261292006761	anticodon binding site; other site
261292006762	Sporulation related domain; Region: SPOR; pfam05036
261292006763	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
261292006764	catalytic residues [active]
261292006765	hinge region; other site
261292006766	alpha helical domain; other site
261292006767	methionine sulfoxide reductase A; Provisional; Region: PRK14054
261292006768	HDOD domain; Region: HDOD; pfam08668
261292006769	GAF domain; Region: GAF_3; pfam13492
261292006770	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
261292006771	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
261292006772	catalytic site [active]
261292006773	G-X2-G-X-G-K; other site
261292006774	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
261292006775	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
261292006776	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
261292006777	Zn2+ binding site [ion binding]; other site
261292006778	Mg2+ binding site [ion binding]; other site
261292006779	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
261292006780	synthetase active site [active]
261292006781	NTP binding site [chemical binding]; other site
261292006782	metal binding site [ion binding]; metal-binding site
261292006783	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
261292006784	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
261292006785	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
261292006786	signal recognition particle protein; Provisional; Region: PRK10867
261292006787	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
261292006788	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
261292006789	P loop; other site
261292006790	GTP binding site [chemical binding]; other site
261292006791	Signal peptide binding domain; Region: SRP_SPB; pfam02978
261292006792	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
261292006793	trimer interface [polypeptide binding]; other site
261292006794	active site
261292006795	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
261292006796	Flavoprotein; Region: Flavoprotein; pfam02441
261292006797	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
261292006798	hypothetical protein; Reviewed; Region: PRK00024
261292006799	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
261292006800	MPN+ (JAMM) motif; other site
261292006801	Zinc-binding site [ion binding]; other site
261292006802	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
261292006803	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
261292006804	Fatty acid desaturase; Region: FA_desaturase; pfam00487
261292006805	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
261292006806	Di-iron ligands [ion binding]; other site
261292006807	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
261292006808	Transposase; Region: DDE_Tnp_ISL3; pfam01610
261292006809	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
261292006810	pseudouridine synthase; Region: TIGR00093
261292006811	active site
261292006812	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
261292006813	catalytic core [active]
261292006814	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
261292006815	YGGT family; Region: YGGT; pfam02325
261292006816	YGGT family; Region: YGGT; pfam02325
261292006817	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
261292006818	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
261292006819	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
261292006820	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
261292006821	DNA binding site [nucleotide binding]
261292006822	catalytic residue [active]
261292006823	H2TH interface [polypeptide binding]; other site
261292006824	putative catalytic residues [active]
261292006825	turnover-facilitating residue; other site
261292006826	intercalation triad [nucleotide binding]; other site
261292006827	8OG recognition residue [nucleotide binding]; other site
261292006828	putative reading head residues; other site
261292006829	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
261292006830	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
261292006831	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
261292006832	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
261292006833	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
261292006834	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
261292006835	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
261292006836	Walker A/P-loop; other site
261292006837	ATP binding site [chemical binding]; other site
261292006838	Q-loop/lid; other site
261292006839	ABC transporter signature motif; other site
261292006840	Walker B; other site
261292006841	D-loop; other site
261292006842	H-loop/switch region; other site
261292006843	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
261292006844	ligand binding site [chemical binding]; other site
261292006845	N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045
261292006846	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
261292006847	active site
261292006848	putative substrate binding pocket [chemical binding]; other site
261292006849	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
261292006850	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
261292006851	S-adenosylmethionine binding site [chemical binding]; other site
261292006852	phosphoglycolate phosphatase; Provisional; Region: PRK13222
261292006853	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
261292006854	motif II; other site
261292006855	Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840
261292006856	DNA binding residues [nucleotide binding]
261292006857	MerR family regulatory protein; Region: MerR; pfam00376
261292006858	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
261292006859	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
261292006860	active site
261292006861	DNA binding site [nucleotide binding]
261292006862	Int/Topo IB signature motif; other site
261292006863	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
261292006864	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
261292006865	non-specific DNA binding site [nucleotide binding]; other site
261292006866	salt bridge; other site
261292006867	sequence-specific DNA binding site [nucleotide binding]; other site
261292006868	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
261292006869	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
261292006870	GSH binding site [chemical binding]; other site
261292006871	catalytic residues [active]
261292006872	pyruvate dehydrogenase; Provisional; Region: PRK06546
261292006873	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
261292006874	PYR/PP interface [polypeptide binding]; other site
261292006875	tetramer interface [polypeptide binding]; other site
261292006876	dimer interface [polypeptide binding]; other site
261292006877	TPP binding site [chemical binding]; other site
261292006878	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
261292006879	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
261292006880	TPP-binding site [chemical binding]; other site
261292006881	Protein of unknown function (DUF3309); Region: DUF3309; pfam11752
261292006882	CsbD-like; Region: CsbD; pfam05532
261292006883	CsbD-like; Region: CsbD; pfam05532
261292006884	Entericidin EcnA/B family; Region: Entericidin; pfam08085
261292006885	Transposase; Region: HTH_Tnp_1; pfam01527
261292006886	putative transposase OrfB; Reviewed; Region: PHA02517
261292006887	HTH-like domain; Region: HTH_21; pfam13276
261292006888	Integrase core domain; Region: rve; pfam00665
261292006889	Integrase core domain; Region: rve_3; cl15866
261292006890	putative transposase OrfB; Reviewed; Region: PHA02517
261292006891	HTH-like domain; Region: HTH_21; pfam13276
261292006892	Integrase core domain; Region: rve; pfam00665
261292006893	Integrase core domain; Region: rve_3; cl15866
261292006894	Transposase; Region: HTH_Tnp_1; pfam01527
261292006895	Transposase IS200 like; Region: Y1_Tnp; cl00848
261292006896	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
261292006897	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
261292006898	GIY-YIG motif/motif A; other site
261292006899	putative active site [active]
261292006900	putative metal binding site [ion binding]; other site
261292006901	Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436
261292006902	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
261292006903	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
261292006904	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
261292006905	Putative phosphatase (DUF442); Region: DUF442; cl17385
261292006906	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
261292006907	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
261292006908	putative DNA binding site [nucleotide binding]; other site
261292006909	dimerization interface [polypeptide binding]; other site
261292006910	putative Zn2+ binding site [ion binding]; other site
261292006911	Predicted transporter component [General function prediction only]; Region: COG2391
261292006912	Sulphur transport; Region: Sulf_transp; pfam04143
261292006913	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
261292006914	Predicted transporter component [General function prediction only]; Region: COG2391
261292006915	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
261292006916	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
261292006917	plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647
261292006918	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
261292006919	Soluble P-type ATPase [General function prediction only]; Region: COG4087
261292006920	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
261292006921	Homeodomain-like domain; Region: HTH_23; cl17451
261292006922	Transposase; Region: HTH_Tnp_1; cl17663
261292006923	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
261292006924	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
261292006925	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
261292006926	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
261292006927	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
261292006928	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
261292006929	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
261292006930	Protein of unknown function (DUF3579); Region: DUF3579; pfam12112
261292006931	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
261292006932	Catalytic site [active]
261292006933	Transposase domain (DUF772); Region: DUF772; pfam05598
261292006934	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
261292006935	DDE superfamily endonuclease; Region: DDE_4; cl17710
261292006936	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
261292006937	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
261292006938	S-adenosylmethionine binding site [chemical binding]; other site
261292006939	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
261292006940	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
261292006941	HlyD family secretion protein; Region: HlyD_3; pfam13437
261292006942	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
261292006943	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
261292006944	poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939
261292006945	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
261292006946	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
261292006947	DNA binding residues [nucleotide binding]
261292006948	dimer interface [polypeptide binding]; other site
261292006949	copper binding site [ion binding]; other site
261292006950	Domain of unknown function (DUF4396); Region: DUF4396; pfam14342
261292006951	short chain dehydrogenase; Validated; Region: PRK06182
261292006952	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
261292006953	NADP binding site [chemical binding]; other site
261292006954	active site
261292006955	steroid binding site; other site
261292006956	diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921
261292006957	CoA binding domain; Region: CoA_binding; cl17356
261292006958	RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204
261292006959	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
261292006960	putative active site [active]
261292006961	Protein of unknown function (DUF504); Region: DUF504; pfam04457
261292006962	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
261292006963	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
261292006964	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
261292006965	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
261292006966	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
261292006967	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
261292006968	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
261292006969	Transposase; Region: HTH_Tnp_1; cl17663
261292006970	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
261292006971	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
261292006972	FecR protein; Region: FecR; pfam04773
261292006973	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
261292006974	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
261292006975	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
261292006976	IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; Region: IPT_PCSR; cd00603
261292006977	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
261292006978	IPT/TIG domain; Region: TIG; pfam01833
261292006979	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
261292006980	putative CheA interaction surface; other site
261292006981	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
261292006982	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
261292006983	HAMP domain; Region: HAMP; pfam00672
261292006984	dimerization interface [polypeptide binding]; other site
261292006985	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
261292006986	dimer interface [polypeptide binding]; other site
261292006987	putative CheW interface [polypeptide binding]; other site
261292006988	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
261292006989	putative CheA interaction surface; other site
261292006990	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
261292006991	Tar ligand binding domain homologue; Region: TarH; pfam02203
261292006992	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
261292006993	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
261292006994	dimerization interface [polypeptide binding]; other site
261292006995	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
261292006996	dimer interface [polypeptide binding]; other site
261292006997	putative CheW interface [polypeptide binding]; other site
261292006998	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
261292006999	putative CheA interaction surface; other site
261292007000	CHASE3 domain; Region: CHASE3; cl05000
261292007001	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
261292007002	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
261292007003	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
261292007004	dimer interface [polypeptide binding]; other site
261292007005	putative CheW interface [polypeptide binding]; other site
261292007006	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
261292007007	Transposase; Region: HTH_Tnp_1; pfam01527
261292007008	putative transposase OrfB; Reviewed; Region: PHA02517
261292007009	HTH-like domain; Region: HTH_21; pfam13276
261292007010	Integrase core domain; Region: rve; pfam00665
261292007011	Integrase core domain; Region: rve_3; pfam13683
261292007012	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
261292007013	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
261292007014	HAMP domain; Region: HAMP; pfam00672
261292007015	dimerization interface [polypeptide binding]; other site
261292007016	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
261292007017	dimer interface [polypeptide binding]; other site
261292007018	putative CheW interface [polypeptide binding]; other site
261292007019	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
261292007020	putative CheA interaction surface; other site
261292007021	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
261292007022	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
261292007023	dimer interface [polypeptide binding]; other site
261292007024	putative metal binding site [ion binding]; other site
261292007025	Peptidase family M48; Region: Peptidase_M48; pfam01435
261292007026	Dodecin; Region: Dodecin; pfam07311
261292007027	Protein of unknown function (DUF3622); Region: DUF3622; pfam12286
261292007028	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
261292007029	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
261292007030	HIGH motif; other site
261292007031	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
261292007032	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
261292007033	active site
261292007034	KMSKS motif; other site
261292007035	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
261292007036	tRNA binding surface [nucleotide binding]; other site
261292007037	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
261292007038	Lipopolysaccharide-assembly; Region: LptE; pfam04390
261292007039	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
261292007040	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
261292007041	Transposase domain (DUF772); Region: DUF772; pfam05598
261292007042	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
261292007043	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
261292007044	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
261292007045	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
261292007046	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
261292007047	substrate binding pocket [chemical binding]; other site
261292007048	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
261292007049	B12 binding site [chemical binding]; other site
261292007050	cobalt ligand [ion binding]; other site
261292007051	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
261292007052	MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098
261292007053	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
261292007054	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
261292007055	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
261292007056	S-adenosylmethionine binding site [chemical binding]; other site
261292007057	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
261292007058	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
261292007059	ATP-grasp domain; Region: ATP-grasp_4; cl17255
261292007060	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
261292007061	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
261292007062	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
261292007063	carboxyltransferase (CT) interaction site; other site
261292007064	biotinylation site [posttranslational modification]; other site
261292007065	Dehydroquinase class II; Region: DHquinase_II; pfam01220
261292007066	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
261292007067	trimer interface [polypeptide binding]; other site
261292007068	active site
261292007069	dimer interface [polypeptide binding]; other site
261292007070	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
261292007071	Mrr N-terminal domain; Region: Mrr_N; pfam14338
261292007072	Restriction endonuclease; Region: Mrr_cat; pfam04471
261292007073	integrase; Provisional; Region: int; PHA02601
261292007074	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
261292007075	active site
261292007076	DNA binding site [nucleotide binding]
261292007077	Int/Topo IB signature motif; other site
261292007078	Transposase domain (DUF772); Region: DUF772; pfam05598
261292007079	Transposase; Region: HTH_Tnp_1; cl17663
261292007080	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
261292007081	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
261292007082	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
261292007083	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
261292007084	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
261292007085	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
261292007086	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
261292007087	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
261292007088	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
261292007089	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
261292007090	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
261292007091	putative FMN binding site [chemical binding]; other site
261292007092	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u3; cd11540
261292007093	putative metal binding site [ion binding]; other site
261292007094	hypothetical protein; Provisional; Region: PRK10396
261292007095	yecA family protein; Region: ygfB_yecA; TIGR02292
261292007096	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
261292007097	salt bridge; other site
261292007098	non-specific DNA binding site [nucleotide binding]; other site
261292007099	sequence-specific DNA binding site [nucleotide binding]; other site
261292007100	Helix-turn-helix domain; Region: HTH_28; pfam13518
261292007101	Winged helix-turn helix; Region: HTH_29; pfam13551
261292007102	Winged helix-turn helix; Region: HTH_33; pfam13592
261292007103	DDE superfamily endonuclease; Region: DDE_3; pfam13358
261292007104	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
261292007105	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
261292007106	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
261292007107	TM2 domain; Region: TM2; cl00984
261292007108	Domain of unknown function (DUF202); Region: DUF202; pfam02656
261292007109	Protein of unknown function (DUF3175); Region: DUF3175; pfam11373
261292007110	Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519
261292007111	active site flap/lid [active]
261292007112	nucleophilic elbow; other site
261292007113	catalytic triad [active]
261292007114	AAA domain; Region: AAA_26; pfam13500
261292007115	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
261292007116	Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109
261292007117	ADP binding site [chemical binding]; other site
261292007118	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
261292007119	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
261292007120	S-adenosylmethionine binding site [chemical binding]; other site
261292007121	pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738
261292007122	TAP-like protein; Region: Abhydrolase_4; pfam08386
261292007123	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
261292007124	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
261292007125	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
261292007126	catalytic residue [active]
261292007127	biotin synthase; Region: bioB; TIGR00433
261292007128	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
261292007129	FeS/SAM binding site; other site
261292007130	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
261292007131	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
261292007132	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
261292007133	active site
261292007134	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
261292007135	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
261292007136	Secretin and TonB N terminus short domain; Region: STN; smart00965
261292007137	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
261292007138	Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168
261292007139	Pilus assembly protein, PilP; Region: PilP; pfam04351
261292007140	Pilus assembly protein, PilO; Region: PilO; pfam04350
261292007141	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
261292007142	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
261292007143	Cell division protein FtsA; Region: FtsA; cl17206
261292007144	Competence protein A; Region: Competence_A; pfam11104
261292007145	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
261292007146	Cell division protein FtsA; Region: FtsA; cl17206
261292007147	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
261292007148	Transglycosylase; Region: Transgly; pfam00912
261292007149	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
261292007150	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
261292007151	dimer interface [polypeptide binding]; other site
261292007152	active site
261292007153	aspartate-rich active site metal binding site; other site
261292007154	allosteric magnesium binding site [ion binding]; other site
261292007155	Schiff base residues; other site
261292007156	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
261292007157	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
261292007158	G1 box; other site
261292007159	Walker A/P-loop; other site
261292007160	GTP/Mg2+ binding site [chemical binding]; other site
261292007161	ATP binding site [chemical binding]; other site
261292007162	Switch I region; other site
261292007163	G2 box; other site
261292007164	G3 box; other site
261292007165	Switch II region; other site
261292007166	G4 box; other site
261292007167	G5 box; other site
261292007168	Type III pantothenate kinase; Region: Pan_kinase; cl17198
261292007169	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
261292007170	HTH domain; Region: HTH_11; pfam08279
261292007171	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
261292007172	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
261292007173	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
261292007174	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
261292007175	alphaNTD homodimer interface [polypeptide binding]; other site
261292007176	alphaNTD - beta interaction site [polypeptide binding]; other site
261292007177	alphaNTD - beta' interaction site [polypeptide binding]; other site
261292007178	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
261292007179	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
261292007180	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
261292007181	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
261292007182	RNA binding surface [nucleotide binding]; other site
261292007183	30S ribosomal protein S11; Validated; Region: PRK05309
261292007184	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
261292007185	30S ribosomal protein S13; Region: bact_S13; TIGR03631
261292007186	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
261292007187	rRNA binding site [nucleotide binding]; other site
261292007188	predicted 30S ribosome binding site; other site
261292007189	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
261292007190	SecY translocase; Region: SecY; pfam00344
261292007191	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
261292007192	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
261292007193	23S rRNA binding site [nucleotide binding]; other site
261292007194	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
261292007195	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
261292007196	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
261292007197	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
261292007198	5S rRNA interface [nucleotide binding]; other site
261292007199	23S rRNA interface [nucleotide binding]; other site
261292007200	L5 interface [polypeptide binding]; other site
261292007201	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
261292007202	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
261292007203	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
261292007204	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
261292007205	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
261292007206	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
261292007207	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
261292007208	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
261292007209	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
261292007210	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
261292007211	RNA binding site [nucleotide binding]; other site
261292007212	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
261292007213	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
261292007214	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
261292007215	23S rRNA interface [nucleotide binding]; other site
261292007216	putative translocon interaction site; other site
261292007217	signal recognition particle (SRP54) interaction site; other site
261292007218	L23 interface [polypeptide binding]; other site
261292007219	trigger factor interaction site; other site
261292007220	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
261292007221	23S rRNA interface [nucleotide binding]; other site
261292007222	5S rRNA interface [nucleotide binding]; other site
261292007223	putative antibiotic binding site [chemical binding]; other site
261292007224	L25 interface [polypeptide binding]; other site
261292007225	L27 interface [polypeptide binding]; other site
261292007226	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
261292007227	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
261292007228	G-X-X-G motif; other site
261292007229	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
261292007230	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
261292007231	putative translocon binding site; other site
261292007232	protein-rRNA interface [nucleotide binding]; other site
261292007233	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
261292007234	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
261292007235	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
261292007236	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
261292007237	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
261292007238	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
261292007239	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
261292007240	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
261292007241	elongation factor Tu; Reviewed; Region: PRK00049
261292007242	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
261292007243	G1 box; other site
261292007244	GEF interaction site [polypeptide binding]; other site
261292007245	GTP/Mg2+ binding site [chemical binding]; other site
261292007246	Switch I region; other site
261292007247	G2 box; other site
261292007248	G3 box; other site
261292007249	Switch II region; other site
261292007250	G4 box; other site
261292007251	G5 box; other site
261292007252	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
261292007253	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
261292007254	Antibiotic Binding Site [chemical binding]; other site
261292007255	elongation factor G; Reviewed; Region: PRK00007
261292007256	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
261292007257	G1 box; other site
261292007258	putative GEF interaction site [polypeptide binding]; other site
261292007259	GTP/Mg2+ binding site [chemical binding]; other site
261292007260	Switch I region; other site
261292007261	G2 box; other site
261292007262	G3 box; other site
261292007263	Switch II region; other site
261292007264	G4 box; other site
261292007265	G5 box; other site
261292007266	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
261292007267	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
261292007268	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
261292007269	30S ribosomal protein S7; Validated; Region: PRK05302
261292007270	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
261292007271	S17 interaction site [polypeptide binding]; other site
261292007272	S8 interaction site; other site
261292007273	16S rRNA interaction site [nucleotide binding]; other site
261292007274	streptomycin interaction site [chemical binding]; other site
261292007275	23S rRNA interaction site [nucleotide binding]; other site
261292007276	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
261292007277	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
261292007278	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
261292007279	argininosuccinate synthase; Provisional; Region: PRK13820
261292007280	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
261292007281	ANP binding site [chemical binding]; other site
261292007282	Substrate Binding Site II [chemical binding]; other site
261292007283	Substrate Binding Site I [chemical binding]; other site
261292007284	ornithine carbamoyltransferase; Provisional; Region: PRK00779
261292007285	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
261292007286	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
261292007287	acetylornithine aminotransferase; Provisional; Region: PRK02627
261292007288	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
261292007289	inhibitor-cofactor binding pocket; inhibition site
261292007290	pyridoxal 5'-phosphate binding site [chemical binding]; other site
261292007291	catalytic residue [active]
261292007292	DNA gyrase subunit A; Validated; Region: PRK05560
261292007293	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
261292007294	CAP-like domain; other site
261292007295	active site
261292007296	primary dimer interface [polypeptide binding]; other site
261292007297	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
261292007298	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
261292007299	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
261292007300	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
261292007301	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
261292007302	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
261292007303	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
261292007304	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
261292007305	homodimer interface [polypeptide binding]; other site
261292007306	substrate-cofactor binding pocket; other site
261292007307	pyridoxal 5'-phosphate binding site [chemical binding]; other site
261292007308	catalytic residue [active]
261292007309	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
261292007310	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
261292007311	putative ligand binding site [chemical binding]; other site
261292007312	putative NAD binding site [chemical binding]; other site
261292007313	putative catalytic site [active]
261292007314	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
261292007315	L-serine binding site [chemical binding]; other site
261292007316	ACT domain interface; other site
261292007317	Chorismate mutase type II; Region: CM_2; cl00693
261292007318	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
261292007319	Prephenate dehydratase; Region: PDT; pfam00800
261292007320	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
261292007321	putative L-Phe binding site [chemical binding]; other site
261292007322	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
261292007323	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
261292007324	pyridoxal 5'-phosphate binding site [chemical binding]; other site
261292007325	homodimer interface [polypeptide binding]; other site
261292007326	catalytic residue [active]
261292007327	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
261292007328	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
261292007329	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
261292007330	prephenate dehydrogenase; Validated; Region: PRK08507
261292007331	Response regulator receiver domain; Region: Response_reg; pfam00072
261292007332	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292007333	active site
261292007334	phosphorylation site [posttranslational modification]
261292007335	intermolecular recognition site; other site
261292007336	dimerization interface [polypeptide binding]; other site
261292007337	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292007338	Response regulator receiver domain; Region: Response_reg; pfam00072
261292007339	active site
261292007340	phosphorylation site [posttranslational modification]
261292007341	intermolecular recognition site; other site
261292007342	dimerization interface [polypeptide binding]; other site
261292007343	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
261292007344	CheB methylesterase; Region: CheB_methylest; pfam01339
261292007345	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
261292007346	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
261292007347	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
261292007348	PAS domain; Region: PAS_9; pfam13426
261292007349	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292007350	putative active site [active]
261292007351	heme pocket [chemical binding]; other site
261292007352	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
261292007353	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
261292007354	metal binding site [ion binding]; metal-binding site
261292007355	active site
261292007356	I-site; other site
261292007357	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
261292007358	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
261292007359	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
261292007360	Helix-turn-helix domain; Region: HTH_28; pfam13518
261292007361	Winged helix-turn helix; Region: HTH_29; pfam13551
261292007362	Winged helix-turn helix; Region: HTH_33; pfam13592
261292007363	DDE superfamily endonuclease; Region: DDE_3; pfam13358
261292007364	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
261292007365	DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453
261292007366	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
261292007367	putative active site [active]
261292007368	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
261292007369	putative active site [active]
261292007370	RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401
261292007371	Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189
261292007372	ATP-grasp domain; Region: ATP-grasp_4; cl17255
261292007373	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
261292007374	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
261292007375	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
261292007376	SelR domain; Region: SelR; pfam01641
261292007377	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
261292007378	TIR domain; Region: TIR_2; pfam13676
261292007379	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
261292007380	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
261292007381	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
261292007382	Zn2+ binding site [ion binding]; other site
261292007383	Mg2+ binding site [ion binding]; other site
261292007384	Carbonic anhydrase; Region: Pro_CA; smart00947
261292007385	active site clefts [active]
261292007386	zinc binding site [ion binding]; other site
261292007387	dimer interface [polypeptide binding]; other site
261292007388	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
261292007389	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
261292007390	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
261292007391	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
261292007392	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
261292007393	Walker A/P-loop; other site
261292007394	ATP binding site [chemical binding]; other site
261292007395	Q-loop/lid; other site
261292007396	ABC transporter signature motif; other site
261292007397	Walker B; other site
261292007398	D-loop; other site
261292007399	H-loop/switch region; other site
261292007400	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
261292007401	TPR motif; other site
261292007402	binding surface
261292007403	Protein of unknown function (DUF4242); Region: DUF4242; pfam14026
261292007404	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
261292007405	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
261292007406	Bacterial Ig-like domain; Region: Big_5; pfam13205
261292007407	Bacterial Ig-like domain; Region: Big_5; pfam13205
261292007408	Bacterial Ig-like domain; Region: Big_5; pfam13205
261292007409	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
261292007410	TPR repeat; Region: TPR_11; pfam13414
261292007411	binding surface
261292007412	TPR motif; other site
261292007413	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
261292007414	binding surface
261292007415	TPR motif; other site
261292007416	Tetratricopeptide repeat; Region: TPR_12; pfam13424
261292007417	TPR repeat; Region: TPR_11; pfam13414
261292007418	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
261292007419	binding surface
261292007420	TPR motif; other site
261292007421	TPR repeat; Region: TPR_11; pfam13414
261292007422	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
261292007423	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
261292007424	Response regulator receiver domain; Region: Response_reg; pfam00072
261292007425	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292007426	active site
261292007427	phosphorylation site [posttranslational modification]
261292007428	intermolecular recognition site; other site
261292007429	dimerization interface [polypeptide binding]; other site
261292007430	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
261292007431	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
261292007432	dimerization interface [polypeptide binding]; other site
261292007433	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
261292007434	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292007435	putative active site [active]
261292007436	heme pocket [chemical binding]; other site
261292007437	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
261292007438	dimer interface [polypeptide binding]; other site
261292007439	phosphorylation site [posttranslational modification]
261292007440	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292007441	ATP binding site [chemical binding]; other site
261292007442	Mg2+ binding site [ion binding]; other site
261292007443	G-X-G motif; other site
261292007444	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
261292007445	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292007446	active site
261292007447	phosphorylation site [posttranslational modification]
261292007448	intermolecular recognition site; other site
261292007449	dimerization interface [polypeptide binding]; other site
261292007450	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
261292007451	putative binding surface; other site
261292007452	active site
261292007453	exopolysaccharide biosynthesis operon protein EpsL; Region: EpsL; TIGR03014
261292007454	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
261292007455	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
261292007456	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
261292007457	putative hydrolase; Provisional; Region: PRK11460
261292007458	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
261292007459	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
261292007460	TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779
261292007461	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
261292007462	N-terminal plug; other site
261292007463	ligand-binding site [chemical binding]; other site
261292007464	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
261292007465	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
261292007466	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
261292007467	homodimer interface [polypeptide binding]; other site
261292007468	Walker A motif; other site
261292007469	ATP binding site [chemical binding]; other site
261292007470	hydroxycobalamin binding site [chemical binding]; other site
261292007471	Walker B motif; other site
261292007472	cobyric acid synthase; Provisional; Region: PRK00784
261292007473	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
261292007474	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
261292007475	catalytic triad [active]
261292007476	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
261292007477	homotrimer interface [polypeptide binding]; other site
261292007478	Walker A motif; other site
261292007479	GTP binding site [chemical binding]; other site
261292007480	Walker B motif; other site
261292007481	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
261292007482	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
261292007483	putative dimer interface [polypeptide binding]; other site
261292007484	active site pocket [active]
261292007485	putative cataytic base [active]
261292007486	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
261292007487	catalytic core [active]
261292007488	cobalamin synthase; Reviewed; Region: cobS; PRK00235
261292007489	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats with a...; Region: EPT_RTPC-like; cl00288
261292007490	methane monooxygenase/ammonia monooxygenase, subunit B; Region: CH4_NH3mon_ox_B; TIGR03079
261292007491	Monooxygenase subunit B protein; Region: Monooxygenase_B; pfam04744
261292007492	methane monooxygenase/ammonia monooxygenase, subunit A; Region: CH4_NH3mon_ox_A; TIGR03080
261292007493	Ammonia monooxygenase/methane monooxygenase, subunit C; Region: AmoC; pfam04896
261292007494	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
261292007495	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
261292007496	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
261292007497	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
261292007498	active site
261292007499	Transposase domain (DUF772); Region: DUF772; pfam05598
261292007500	HI0933-like protein; Region: HI0933_like; pfam03486
261292007501	Protein of unknown function (DUF2909); Region: DUF2909; pfam11137
261292007502	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
261292007503	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
261292007504	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
261292007505	BON domain; Region: BON; pfam04972
261292007506	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
261292007507	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
261292007508	trimer interface [polypeptide binding]; other site
261292007509	active site
261292007510	substrate binding site [chemical binding]; other site
261292007511	CoA binding site [chemical binding]; other site
261292007512	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
261292007513	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
261292007514	pyridoxal 5'-phosphate binding site [chemical binding]; other site
261292007515	homodimer interface [polypeptide binding]; other site
261292007516	catalytic residue [active]
261292007517	Copper resistance protein D; Region: CopD; cl00563
261292007518	cytochrome c-550; Provisional; Region: psbV; PRK13621
261292007519	Cytochrome c; Region: Cytochrom_C; pfam00034
261292007520	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
261292007521	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
261292007522	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
261292007523	C factor cell-cell signaling protein; Provisional; Region: PRK09009
261292007524	NADP binding site [chemical binding]; other site
261292007525	homodimer interface [polypeptide binding]; other site
261292007526	active site
261292007527	CLUSTERIN Beta chain; Region: CLb; smart00030
261292007528	Domain of unknown function DUF1828; Region: DUF1828; pfam08861
261292007529	Domain of unknown function DUF1829; Region: DUF1829; pfam08862
261292007530	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
261292007531	active site
261292007532	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
261292007533	hypothetical protein; Provisional; Region: PRK08609
261292007534	active site
261292007535	primer binding site [nucleotide binding]; other site
261292007536	NTP  binding site [chemical binding]; other site
261292007537	metal binding triad [ion binding]; metal-binding site
261292007538	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
261292007539	active site
261292007540	Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951
261292007541	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
261292007542	hypothetical protein; Reviewed; Region: PRK09588
261292007543	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
261292007544	30S subunit binding site; other site
261292007545	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
261292007546	DNA-binding site [nucleotide binding]; DNA binding site
261292007547	RNA-binding motif; other site
261292007548	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
261292007549	Isochorismatase family; Region: Isochorismatase; pfam00857
261292007550	catalytic triad [active]
261292007551	metal binding site [ion binding]; metal-binding site
261292007552	conserved cis-peptide bond; other site
261292007553	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
261292007554	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
261292007555	active site
261292007556	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
261292007557	FOG: CBS domain [General function prediction only]; Region: COG0517
261292007558	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
261292007559	Found in ATP-dependent protease La (LON); Region: LON; smart00464
261292007560	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
261292007561	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
261292007562	Walker A motif; other site
261292007563	ATP binding site [chemical binding]; other site
261292007564	Walker B motif; other site
261292007565	arginine finger; other site
261292007566	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
261292007567	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
261292007568	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
261292007569	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
261292007570	active site
261292007571	Int/Topo IB signature motif; other site
261292007572	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
261292007573	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
261292007574	DNA binding site [nucleotide binding]
261292007575	active site
261292007576	heat shock protein 90; Provisional; Region: PRK05218
261292007577	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292007578	ATP binding site [chemical binding]; other site
261292007579	Mg2+ binding site [ion binding]; other site
261292007580	G-X-G motif; other site
261292007581	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
261292007582	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
261292007583	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
261292007584	NADH-ubiquinone oxidoreductase chain 4, amino terminus; Region: Oxidored_q5_N; pfam01059
261292007585	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
261292007586	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
261292007587	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
261292007588	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
261292007589	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
261292007590	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
261292007591	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
261292007592	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
261292007593	4Fe-4S binding domain; Region: Fer4; pfam00037
261292007594	4Fe-4S binding domain; Region: Fer4; pfam00037
261292007595	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
261292007596	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
261292007597	NADH dehydrogenase subunit G; Validated; Region: PRK09129
261292007598	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
261292007599	catalytic loop [active]
261292007600	iron binding site [ion binding]; other site
261292007601	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
261292007602	MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772
261292007603	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
261292007604	SLBB domain; Region: SLBB; pfam10531
261292007605	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
261292007606	NADH dehydrogenase subunit E; Validated; Region: PRK07539
261292007607	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
261292007608	putative dimer interface [polypeptide binding]; other site
261292007609	[2Fe-2S] cluster binding site [ion binding]; other site
261292007610	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
261292007611	NADH dehydrogenase subunit D; Validated; Region: PRK06075
261292007612	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
261292007613	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
261292007614	NADH dehydrogenase subunit B; Validated; Region: PRK06411
261292007615	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
261292007616	Preprotein translocase SecG subunit; Region: SecG; pfam03840
261292007617	triosephosphate isomerase; Provisional; Region: PRK14567
261292007618	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
261292007619	substrate binding site [chemical binding]; other site
261292007620	dimer interface [polypeptide binding]; other site
261292007621	catalytic triad [active]
261292007622	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14252
261292007623	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
261292007624	Walker A/P-loop; other site
261292007625	ATP binding site [chemical binding]; other site
261292007626	Q-loop/lid; other site
261292007627	ABC transporter signature motif; other site
261292007628	Walker B; other site
261292007629	D-loop; other site
261292007630	H-loop/switch region; other site
261292007631	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
261292007632	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
261292007633	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
261292007634	dimer interface [polypeptide binding]; other site
261292007635	conserved gate region; other site
261292007636	putative PBP binding loops; other site
261292007637	ABC-ATPase subunit interface; other site
261292007638	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
261292007639	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
261292007640	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
261292007641	Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447
261292007642	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
261292007643	Cysteine-rich domain; Region: CCG; pfam02754
261292007644	Cysteine-rich domain; Region: CCG; pfam02754
261292007645	FAD binding domain; Region: FAD_binding_4; pfam01565
261292007646	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
261292007647	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
261292007648	FAD binding domain; Region: FAD_binding_4; pfam01565
261292007649	2-hydroxy-3-oxopropionate reductase; Region: tartro_sem_red; TIGR01505
261292007650	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
261292007651	bile acid transporter; Region: bass; TIGR00841
261292007652	Sodium Bile acid symporter family; Region: SBF; pfam01758
261292007653	Methyltransferase domain; Region: Methyltransf_31; pfam13847
261292007654	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
261292007655	S-adenosylmethionine binding site [chemical binding]; other site
261292007656	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
261292007657	structural tetrad; other site
261292007658	PEP-CTERM motif; Region: VPEP; pfam07589
261292007659	A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603
261292007660	ligand binding surface [chemical binding]; other site
261292007661	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
261292007662	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
261292007663	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
261292007664	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
261292007665	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
261292007666	Protein of unknown function (DUF422); Region: DUF422; cl00991
261292007667	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
261292007668	catalytic nucleophile [active]
261292007669	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
261292007670	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
261292007671	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
261292007672	active site
261292007673	dimer interface [polypeptide binding]; other site
261292007674	effector binding site; other site
261292007675	P63C domain; Region: P63C; pfam10546
261292007676	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
261292007677	Uncharacterized conserved protein [Function unknown]; Region: COG3025
261292007678	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
261292007679	putative active site [active]
261292007680	putative metal binding residues [ion binding]; other site
261292007681	signature motif; other site
261292007682	putative triphosphate binding site [ion binding]; other site
261292007683	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
261292007684	E3 Ubiquitin ligase; Region: GIDE; pfam12483
261292007685	LemA family; Region: LemA; cl00742
261292007686	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
261292007687	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
261292007688	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
261292007689	ligand binding site [chemical binding]; other site
261292007690	flexible hinge region; other site
261292007691	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
261292007692	putative switch regulator; other site
261292007693	non-specific DNA interactions [nucleotide binding]; other site
261292007694	DNA binding site [nucleotide binding]
261292007695	sequence specific DNA binding site [nucleotide binding]; other site
261292007696	putative cAMP binding site [chemical binding]; other site
261292007697	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
261292007698	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
261292007699	active site residue [active]
261292007700	Transglutaminase-like superfamily; Region: Transglut_core; cl17362
261292007701	HDOD domain; Region: HDOD; pfam08668
261292007702	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
261292007703	putative active site [active]
261292007704	heme pocket [chemical binding]; other site
261292007705	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
261292007706	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
261292007707	metal binding site [ion binding]; metal-binding site
261292007708	active site
261292007709	I-site; other site
261292007710	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
261292007711	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
261292007712	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
261292007713	dimer interface [polypeptide binding]; other site
261292007714	active site
261292007715	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
261292007716	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
261292007717	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
261292007718	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
261292007719	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
261292007720	substrate binding site [chemical binding]; other site
261292007721	oxyanion hole (OAH) forming residues; other site
261292007722	trimer interface [polypeptide binding]; other site
261292007723	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
261292007724	ArsC family; Region: ArsC; pfam03960
261292007725	putative ArsC-like catalytic residues; other site
261292007726	putative TRX-like catalytic residues [active]
261292007727	Cupin domain; Region: Cupin_2; pfam07883
261292007728	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
261292007729	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
261292007730	Serine hydrolase; Region: Ser_hydrolase; cl17834
261292007731	MarR family; Region: MarR_2; cl17246
261292007732	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
261292007733	Transposase domain (DUF772); Region: DUF772; pfam05598
261292007734	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
261292007735	DDE superfamily endonuclease; Region: DDE_4; cl17710
261292007736	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
261292007737	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
261292007738	N-terminal plug; other site
261292007739	ligand-binding site [chemical binding]; other site
261292007740	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
261292007741	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
261292007742	polyphosphate kinase; Provisional; Region: PRK05443
261292007743	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
261292007744	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
261292007745	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
261292007746	putative domain interface [polypeptide binding]; other site
261292007747	putative active site [active]
261292007748	catalytic site [active]
261292007749	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
261292007750	putative active site [active]
261292007751	putative domain interface [polypeptide binding]; other site
261292007752	catalytic site [active]
261292007753	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
261292007754	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
261292007755	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
261292007756	catalytic core [active]
261292007757	Y-family of DNA polymerases; Region: PolY; cl12025
261292007758	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
261292007759	active site
261292007760	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
261292007761	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
261292007762	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
261292007763	acyl-activating enzyme (AAE) consensus motif; other site
261292007764	acyl-activating enzyme (AAE) consensus motif; other site
261292007765	putative AMP binding site [chemical binding]; other site
261292007766	putative active site [active]
261292007767	putative CoA binding site [chemical binding]; other site
261292007768	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
261292007769	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
261292007770	active site
261292007771	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
261292007772	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
261292007773	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
261292007774	metal binding site [ion binding]; metal-binding site
261292007775	dimer interface [polypeptide binding]; other site
261292007776	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
261292007777	catalytic residues [active]
261292007778	Transposase domain (DUF772); Region: DUF772; pfam05598
261292007779	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
261292007780	DDE superfamily endonuclease; Region: DDE_4; cl17710
261292007781	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
261292007782	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
261292007783	Glucokinase; Region: Glucokinase; pfam02685
261292007784	glucokinase, proteobacterial type; Region: glk; TIGR00749
261292007785	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
261292007786	putative homodimer interface [polypeptide binding]; other site
261292007787	putative active site pocket [active]
261292007788	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
261292007789	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
261292007790	Transposase; Region: HTH_Tnp_1; pfam01527
261292007791	Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cl03181
261292007792	Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cl03181
261292007793	Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cl03181
261292007794	active site
261292007795	S-adenosylmethionine synthetase; Validated; Region: PRK05250
261292007796	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
261292007797	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
261292007798	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
261292007799	Protein of unknown function (DUF3616); Region: DUF3616; pfam12275
261292007800	putative transposase OrfB; Reviewed; Region: PHA02517
261292007801	HTH-like domain; Region: HTH_21; pfam13276
261292007802	Integrase core domain; Region: rve; pfam00665
261292007803	Integrase core domain; Region: rve_3; cl15866
261292007804	TIGR02594 family protein; Region: TIGR02594
261292007805	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
261292007806	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
261292007807	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292007808	ATP binding site [chemical binding]; other site
261292007809	Mg2+ binding site [ion binding]; other site
261292007810	G-X-G motif; other site
261292007811	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
261292007812	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292007813	active site
261292007814	phosphorylation site [posttranslational modification]
261292007815	intermolecular recognition site; other site
261292007816	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
261292007817	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292007818	active site
261292007819	phosphorylation site [posttranslational modification]
261292007820	intermolecular recognition site; other site
261292007821	dimerization interface [polypeptide binding]; other site
261292007822	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
261292007823	DNA binding residues [nucleotide binding]
261292007824	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
261292007825	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
261292007826	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
261292007827	dimer interface [polypeptide binding]; other site
261292007828	phosphorylation site [posttranslational modification]
261292007829	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292007830	ATP binding site [chemical binding]; other site
261292007831	Mg2+ binding site [ion binding]; other site
261292007832	G-X-G motif; other site
261292007833	Response regulator receiver domain; Region: Response_reg; pfam00072
261292007834	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292007835	active site
261292007836	phosphorylation site [posttranslational modification]
261292007837	intermolecular recognition site; other site
261292007838	dimerization interface [polypeptide binding]; other site
261292007839	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
261292007840	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292007841	active site
261292007842	phosphorylation site [posttranslational modification]
261292007843	intermolecular recognition site; other site
261292007844	dimerization interface [polypeptide binding]; other site
261292007845	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
261292007846	DNA binding residues [nucleotide binding]
261292007847	dimerization interface [polypeptide binding]; other site
261292007848	glycogen branching enzyme; Provisional; Region: PRK05402
261292007849	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
261292007850	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
261292007851	active site
261292007852	catalytic site [active]
261292007853	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
261292007854	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
261292007855	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
261292007856	ligand binding site; other site
261292007857	oligomer interface; other site
261292007858	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
261292007859	dimer interface [polypeptide binding]; other site
261292007860	N-terminal domain interface [polypeptide binding]; other site
261292007861	sulfate 1 binding site; other site
261292007862	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
261292007863	N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796
261292007864	putative active site [active]
261292007865	catalytic site [active]
261292007866	N-terminal catalytic domain of 4-alpha-glucanotransferase; glycoside hydrolase family 57 (GH57); Region: GH57N_TLGT_like; cd10793
261292007867	Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065
261292007868	active site
261292007869	catalytic site [active]
261292007870	homodimer interface [polypeptide binding]; other site
261292007871	Lid 1; other site
261292007872	Domain of unknown function (DUF1925); Region: DUF1925; pfam09094
261292007873	Domain of unknown function (DUF1926); Region: DUF1926; pfam09095
261292007874	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
261292007875	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
261292007876	active site
261292007877	dimer interface [polypeptide binding]; other site
261292007878	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
261292007879	dimer interface [polypeptide binding]; other site
261292007880	active site
261292007881	glycogen synthase; Provisional; Region: glgA; PRK00654
261292007882	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
261292007883	ADP-binding pocket [chemical binding]; other site
261292007884	homodimer interface [polypeptide binding]; other site
261292007885	dihydrolipoamide dehydrogenase; Validated; Region: PRK06292
261292007886	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
261292007887	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
261292007888	Low affinity iron permease; Region: Iron_permease; pfam04120
261292007889	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
261292007890	dimerization interface [polypeptide binding]; other site
261292007891	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
261292007892	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
261292007893	ligand binding site [chemical binding]; other site
261292007894	flexible hinge region; other site
261292007895	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
261292007896	non-specific DNA interactions [nucleotide binding]; other site
261292007897	DNA binding site [nucleotide binding]
261292007898	sequence specific DNA binding site [nucleotide binding]; other site
261292007899	putative cAMP binding site [chemical binding]; other site
261292007900	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
261292007901	catalytic triad [active]
261292007902	dimer interface [polypeptide binding]; other site
261292007903	Ferritin-like domain; Region: Ferritin; pfam00210
261292007904	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
261292007905	dinuclear metal binding motif [ion binding]; other site
261292007906	BolA-like protein; Region: BolA; cl00386
261292007907	CsbD-like; Region: CsbD; pfam05532
261292007908	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
261292007909	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
261292007910	Transposase [DNA replication, recombination, and repair]; Region: COG5433
261292007911	Transposase [DNA replication, recombination, and repair]; Region: COG5433
261292007912	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
261292007913	Protein of unknown function (DUF3494); Region: DUF3494; pfam11999
261292007914	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
261292007915	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
261292007916	dimer interface [polypeptide binding]; other site
261292007917	Transposase; Region: DEDD_Tnp_IS110; pfam01548
261292007918	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
261292007919	FecR protein; Region: FecR; pfam04773
261292007920	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
261292007921	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
261292007922	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
261292007923	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
261292007924	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
261292007925	putative catalytic cysteine [active]
261292007926	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
261292007927	E3 interaction surface; other site
261292007928	lipoyl attachment site [posttranslational modification]; other site
261292007929	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
261292007930	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
261292007931	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
261292007932	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
261292007933	MG2 domain; Region: A2M_N; pfam01835
261292007934	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
261292007935	Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400
261292007936	7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402
261292007937	alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291
261292007938	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
261292007939	putative binding surface; other site
261292007940	active site
261292007941	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292007942	active site
261292007943	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
261292007944	phosphorylation site [posttranslational modification]
261292007945	intermolecular recognition site; other site
261292007946	dimerization interface [polypeptide binding]; other site
261292007947	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292007948	active site
261292007949	phosphorylation site [posttranslational modification]
261292007950	intermolecular recognition site; other site
261292007951	dimerization interface [polypeptide binding]; other site
261292007952	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
261292007953	metal binding site [ion binding]; metal-binding site
261292007954	active site
261292007955	I-site; other site
261292007956	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
261292007957	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
261292007958	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
261292007959	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
261292007960	Ligand Binding Site [chemical binding]; other site
261292007961	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
261292007962	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
261292007963	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
261292007964	RNA binding surface [nucleotide binding]; other site
261292007965	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
261292007966	active site
261292007967	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
261292007968	Flagellar protein YcgR; Region: YcgR_2; pfam12945
261292007969	PilZ domain; Region: PilZ; pfam07238
261292007970	CAAX prenyl protease-related protein; Region: pepcterm_CAAX; TIGR03008
261292007971	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
261292007972	active site
261292007973	DNA polymerase IV; Validated; Region: PRK02406
261292007974	DNA binding site [nucleotide binding]
261292007975	hypothetical protein; Provisional; Region: PRK01842
261292007976	SEC-C motif; Region: SEC-C; pfam02810
261292007977	Predicted periplasmic lipoprotein (DUF2279); Region: DUF2279; pfam10043
261292007978	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
261292007979	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
261292007980	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
261292007981	tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812
261292007982	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
261292007983	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
261292007984	catalytic residue [active]
261292007985	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
261292007986	glycerate dehydrogenase; Provisional; Region: PRK06487
261292007987	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
261292007988	putative ligand binding site [chemical binding]; other site
261292007989	putative NAD binding site [chemical binding]; other site
261292007990	catalytic site [active]
261292007991	CAAX protease self-immunity; Region: Abi; pfam02517
261292007992	replicative DNA helicase; Region: DnaB; TIGR00665
261292007993	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
261292007994	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
261292007995	Walker A motif; other site
261292007996	ATP binding site [chemical binding]; other site
261292007997	Walker B motif; other site
261292007998	DNA binding loops [nucleotide binding]
261292007999	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
261292008000	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
261292008001	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
261292008002	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
261292008003	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
261292008004	generic binding surface II; other site
261292008005	generic binding surface I; other site
261292008006	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
261292008007	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
261292008008	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
261292008009	glutamine binding [chemical binding]; other site
261292008010	catalytic triad [active]
261292008011	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
261292008012	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
261292008013	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
261292008014	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
261292008015	active site
261292008016	ribulose/triose binding site [chemical binding]; other site
261292008017	phosphate binding site [ion binding]; other site
261292008018	substrate (anthranilate) binding pocket [chemical binding]; other site
261292008019	product (indole) binding pocket [chemical binding]; other site
261292008020	HDOD domain; Region: HDOD; pfam08668
261292008021	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
261292008022	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
261292008023	Replication initiation factor; Region: Rep_trans; pfam02486
261292008024	Helix-turn-helix domain; Region: HTH_17; pfam12728
261292008025	P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192
261292008026	Int/Topo IB signature motif; other site
261292008027	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
261292008028	stringent starvation protein A; Provisional; Region: sspA; PRK09481
261292008029	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
261292008030	C-terminal domain interface [polypeptide binding]; other site
261292008031	putative GSH binding site (G-site) [chemical binding]; other site
261292008032	dimer interface [polypeptide binding]; other site
261292008033	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
261292008034	N-terminal domain interface [polypeptide binding]; other site
261292008035	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
261292008036	cytochrome b; Provisional; Region: CYTB; MTH00145
261292008037	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
261292008038	Qi binding site; other site
261292008039	intrachain domain interface; other site
261292008040	interchain domain interface [polypeptide binding]; other site
261292008041	heme bH binding site [chemical binding]; other site
261292008042	heme bL binding site [chemical binding]; other site
261292008043	Qo binding site; other site
261292008044	interchain domain interface [polypeptide binding]; other site
261292008045	intrachain domain interface; other site
261292008046	Qi binding site; other site
261292008047	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
261292008048	Qo binding site; other site
261292008049	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
261292008050	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
261292008051	[2Fe-2S] cluster binding site [ion binding]; other site
261292008052	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
261292008053	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
261292008054	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
261292008055	SWIM/SEC-C metal-binding motif protein, PBPRA1643 family; Region: SWIM_PBPRA1643; TIGR04102
261292008056	SEC-C motif; Region: SEC-C; pfam02810
261292008057	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
261292008058	Peptidase family M23; Region: Peptidase_M23; pfam01551
261292008059	Protein of unknown function (DUF721); Region: DUF721; pfam05258
261292008060	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
261292008061	RNB domain; Region: RNB; pfam00773
261292008062	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
261292008063	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
261292008064	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
261292008065	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
261292008066	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
261292008067	shikimate binding site; other site
261292008068	NAD(P) binding site [chemical binding]; other site
261292008069	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
261292008070	MgtE intracellular N domain; Region: MgtE_N; smart00924
261292008071	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
261292008072	Divalent cation transporter; Region: MgtE; cl00786
261292008073	Predicted flavoprotein [General function prediction only]; Region: COG0431
261292008074	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
261292008075	Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905
261292008076	S4 domain; Region: S4_2; pfam13275
261292008077	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
261292008078	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
261292008079	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
261292008080	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
261292008081	S-adenosylmethionine binding site [chemical binding]; other site
261292008082	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
261292008083	PemK-like protein; Region: PemK; pfam02452
261292008084	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
261292008085	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
261292008086	HlyD family secretion protein; Region: HlyD_3; pfam13437
261292008087	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
261292008088	Maf-like protein; Region: Maf; pfam02545
261292008089	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
261292008090	active site
261292008091	dimer interface [polypeptide binding]; other site
261292008092	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
261292008093	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
261292008094	putative phosphate acyltransferase; Provisional; Region: PRK05331
261292008095	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
261292008096	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
261292008097	dimer interface [polypeptide binding]; other site
261292008098	active site
261292008099	CoA binding pocket [chemical binding]; other site
261292008100	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
261292008101	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
261292008102	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
261292008103	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
261292008104	NAD(P) binding site [chemical binding]; other site
261292008105	homotetramer interface [polypeptide binding]; other site
261292008106	homodimer interface [polypeptide binding]; other site
261292008107	active site
261292008108	acyl carrier protein; Provisional; Region: acpP; PRK00982
261292008109	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
261292008110	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
261292008111	dimer interface [polypeptide binding]; other site
261292008112	active site
261292008113	YceG-like family; Region: YceG; pfam02618
261292008114	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
261292008115	dimerization interface [polypeptide binding]; other site
261292008116	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
261292008117	Ligand binding site; other site
261292008118	Putative Catalytic site; other site
261292008119	DXD motif; other site
261292008120	Predicted membrane protein [Function unknown]; Region: COG2246
261292008121	GtrA-like protein; Region: GtrA; pfam04138
261292008122	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
261292008123	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
261292008124	Protein of unknown function (DUF4019); Region: DUF4019; pfam13211
261292008125	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
261292008126	ZIP Zinc transporter; Region: Zip; pfam02535
261292008127	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
261292008128	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
261292008129	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
261292008130	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
261292008131	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
261292008132	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
261292008133	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
261292008134	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
261292008135	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
261292008136	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
261292008137	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
261292008138	active site
261292008139	catalytic site [active]
261292008140	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
261292008141	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
261292008142	D-xylulose kinase; Region: XylB; TIGR01312
261292008143	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
261292008144	nucleotide binding site [chemical binding]; other site
261292008145	Protoglobin; Region: Protoglobin; pfam11563
261292008146	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
261292008147	active site
261292008148	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
261292008149	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
261292008150	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
261292008151	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
261292008152	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
261292008153	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
261292008154	Soluble P-type ATPase [General function prediction only]; Region: COG4087
261292008155	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
261292008156	Putative phosphatase (DUF442); Region: DUF442; cl17385
261292008157	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
261292008158	dimerization interface [polypeptide binding]; other site
261292008159	putative DNA binding site [nucleotide binding]; other site
261292008160	putative Zn2+ binding site [ion binding]; other site
261292008161	Predicted transporter component [General function prediction only]; Region: COG2391
261292008162	Sulphur transport; Region: Sulf_transp; pfam04143
261292008163	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
261292008164	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
261292008165	HSP70 interaction site [polypeptide binding]; other site
261292008166	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
261292008167	PilZ domain; Region: PilZ; pfam07238
261292008168	Hemin uptake protein hemP; Region: hemP; pfam10636
261292008169	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
261292008170	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
261292008171	heme binding site [chemical binding]; other site
261292008172	ferroxidase pore; other site
261292008173	ferroxidase diiron center [ion binding]; other site
261292008174	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087
261292008175	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
261292008176	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
261292008177	dimer interface [polypeptide binding]; other site
261292008178	ssDNA binding site [nucleotide binding]; other site
261292008179	tetramer (dimer of dimers) interface [polypeptide binding]; other site
261292008180	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
261292008181	Major Facilitator Superfamily; Region: MFS_1; pfam07690
261292008182	putative substrate translocation pore; other site
261292008183	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
261292008184	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
261292008185	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
261292008186	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
261292008187	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
261292008188	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
261292008189	MOFRL family; Region: MOFRL; pfam05161
261292008190	Protein of unknown function (DUF2806); Region: DUF2806; cl12560
261292008191	hydrogenase membrane subunit; Validated; Region: PRK08667
261292008192	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
261292008193	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
261292008194	trimer interface [polypeptide binding]; other site
261292008195	eyelet of channel; other site
261292008196	L,D-transpeptidase; Provisional; Region: PRK10260
261292008197	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
261292008198	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
261292008199	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
261292008200	HupF/HypC family; Region: HupF_HypC; pfam01455
261292008201	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
261292008202	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
261292008203	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
261292008204	dimerization interface [polypeptide binding]; other site
261292008205	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
261292008206	ATP binding site [chemical binding]; other site
261292008207	HypX protein, N-terminal hydrolase domain; Region: FMT_core_HypX_N; cd08650
261292008208	putative active site [active]
261292008209	putative substrate binding site [chemical binding]; other site
261292008210	putative cosubstrate binding site; other site
261292008211	catalytic site [active]
261292008212	C-terminal subdomain of the Formyltransferase-like domain found in HypX-like proteins; Region: FMT_C_HypX; cd08701
261292008213	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
261292008214	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
261292008215	substrate binding site [chemical binding]; other site
261292008216	oxyanion hole (OAH) forming residues; other site
261292008217	trimer interface [polypeptide binding]; other site
261292008218	PEP-CTERM motif; Region: VPEP; pfam07589
261292008219	Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916
261292008220	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
261292008221	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
261292008222	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
261292008223	Walker A/P-loop; other site
261292008224	ATP binding site [chemical binding]; other site
261292008225	Q-loop/lid; other site
261292008226	ABC transporter signature motif; other site
261292008227	Walker B; other site
261292008228	D-loop; other site
261292008229	H-loop/switch region; other site
261292008230	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
261292008231	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
261292008232	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
261292008233	N-terminal plug; other site
261292008234	ligand-binding site [chemical binding]; other site
261292008235	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
261292008236	putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966
261292008237	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
261292008238	dimerization interface [polypeptide binding]; other site
261292008239	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
261292008240	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
261292008241	dimer interface [polypeptide binding]; other site
261292008242	phosphorylation site [posttranslational modification]
261292008243	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292008244	ATP binding site [chemical binding]; other site
261292008245	Mg2+ binding site [ion binding]; other site
261292008246	G-X-G motif; other site
261292008247	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292008248	Response regulator receiver domain; Region: Response_reg; pfam00072
261292008249	active site
261292008250	phosphorylation site [posttranslational modification]
261292008251	intermolecular recognition site; other site
261292008252	dimerization interface [polypeptide binding]; other site
261292008253	Response regulator receiver domain; Region: Response_reg; pfam00072
261292008254	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292008255	active site
261292008256	phosphorylation site [posttranslational modification]
261292008257	intermolecular recognition site; other site
261292008258	dimerization interface [polypeptide binding]; other site
261292008259	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
261292008260	putative binding surface; other site
261292008261	active site
261292008262	Response regulator receiver domain; Region: Response_reg; pfam00072
261292008263	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292008264	active site
261292008265	phosphorylation site [posttranslational modification]
261292008266	intermolecular recognition site; other site
261292008267	dimerization interface [polypeptide binding]; other site
261292008268	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
261292008269	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
261292008270	metal binding site [ion binding]; metal-binding site
261292008271	active site
261292008272	I-site; other site
261292008273	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
261292008274	HDOD domain; Region: HDOD; pfam08668
261292008275	Response regulator receiver domain; Region: Response_reg; pfam00072
261292008276	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292008277	active site
261292008278	phosphorylation site [posttranslational modification]
261292008279	intermolecular recognition site; other site
261292008280	dimerization interface [polypeptide binding]; other site
261292008281	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
261292008282	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
261292008283	metal binding site [ion binding]; metal-binding site
261292008284	active site
261292008285	I-site; other site
261292008286	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
261292008287	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
261292008288	N-terminal plug; other site
261292008289	ligand-binding site [chemical binding]; other site
261292008290	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
261292008291	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
261292008292	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
261292008293	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
261292008294	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
261292008295	N-terminal plug; other site
261292008296	ligand-binding site [chemical binding]; other site
261292008297	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
261292008298	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
261292008299	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292008300	active site
261292008301	phosphorylation site [posttranslational modification]
261292008302	intermolecular recognition site; other site
261292008303	dimerization interface [polypeptide binding]; other site
261292008304	Tetratricopeptide repeat; Region: TPR_12; pfam13424
261292008305	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
261292008306	TPR motif; other site
261292008307	binding surface
261292008308	Tetratricopeptide repeat; Region: TPR_12; pfam13424
261292008309	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
261292008310	binding surface
261292008311	TPR motif; other site
261292008312	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
261292008313	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292008314	ATP binding site [chemical binding]; other site
261292008315	Mg2+ binding site [ion binding]; other site
261292008316	G-X-G motif; other site
261292008317	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262
261292008318	hypothetical protein; Provisional; Region: PRK05409
261292008319	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
261292008320	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
261292008321	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
261292008322	putative GTP cyclohydrolase; Provisional; Region: PRK13674
261292008323	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
261292008324	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
261292008325	TPP-binding site; other site
261292008326	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
261292008327	PYR/PP interface [polypeptide binding]; other site
261292008328	dimer interface [polypeptide binding]; other site
261292008329	TPP binding site [chemical binding]; other site
261292008330	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
261292008331	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
261292008332	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
261292008333	substrate binding pocket [chemical binding]; other site
261292008334	chain length determination region; other site
261292008335	substrate-Mg2+ binding site; other site
261292008336	catalytic residues [active]
261292008337	aspartate-rich region 1; other site
261292008338	active site lid residues [active]
261292008339	aspartate-rich region 2; other site
261292008340	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
261292008341	MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804
261292008342	active site
261292008343	Predicted permeases [General function prediction only]; Region: COG0795
261292008344	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
261292008345	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
261292008346	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
261292008347	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
261292008348	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
261292008349	Protein of unknown function (DUF2959); Region: DUF2959; pfam11172
261292008350	YaeQ protein; Region: YaeQ; pfam07152
261292008351	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
261292008352	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
261292008353	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
261292008354	Predicted chitinase [General function prediction only]; Region: COG3179
261292008355	catalytic residue [active]
261292008356	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
261292008357	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292008358	ATP binding site [chemical binding]; other site
261292008359	Mg2+ binding site [ion binding]; other site
261292008360	G-X-G motif; other site
261292008361	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
261292008362	ATP binding site [chemical binding]; other site
261292008363	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
261292008364	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
261292008365	PEP synthetase regulatory protein; Provisional; Region: PRK05339
261292008366	phosphoenolpyruvate synthase; Validated; Region: PRK06464
261292008367	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
261292008368	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
261292008369	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
261292008370	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
261292008371	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
261292008372	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
261292008373	putative dimerization interface [polypeptide binding]; other site
261292008374	ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040
261292008375	Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212
261292008376	homodimer interface [polypeptide binding]; other site
261292008377	active site
261292008378	heterodimer interface [polypeptide binding]; other site
261292008379	catalytic residue [active]
261292008380	metal binding site [ion binding]; metal-binding site
261292008381	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
261292008382	multimerization interface [polypeptide binding]; other site
261292008383	probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880
261292008384	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
261292008385	Walker A motif; other site
261292008386	ATP binding site [chemical binding]; other site
261292008387	Walker B motif; other site
261292008388	arginine finger; other site
261292008389	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
261292008390	intersubunit interface [polypeptide binding]; other site
261292008391	active site
261292008392	zinc binding site [ion binding]; other site
261292008393	Na+ binding site [ion binding]; other site
261292008394	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
261292008395	TIGR02594 family protein; Region: TIGR02594
261292008396	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
261292008397	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
261292008398	putative binding surface; other site
261292008399	active site
261292008400	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
261292008401	putative binding surface; other site
261292008402	active site
261292008403	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
261292008404	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292008405	ATP binding site [chemical binding]; other site
261292008406	Mg2+ binding site [ion binding]; other site
261292008407	G-X-G motif; other site
261292008408	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
261292008409	Response regulator receiver domain; Region: Response_reg; pfam00072
261292008410	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292008411	active site
261292008412	phosphorylation site [posttranslational modification]
261292008413	intermolecular recognition site; other site
261292008414	dimerization interface [polypeptide binding]; other site
261292008415	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
261292008416	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
261292008417	dimer interface [polypeptide binding]; other site
261292008418	putative CheW interface [polypeptide binding]; other site
261292008419	threonine dehydratase; Reviewed; Region: PRK09224
261292008420	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
261292008421	tetramer interface [polypeptide binding]; other site
261292008422	pyridoxal 5'-phosphate binding site [chemical binding]; other site
261292008423	catalytic residue [active]
261292008424	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
261292008425	putative Ile/Val binding site [chemical binding]; other site
261292008426	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
261292008427	putative Ile/Val binding site [chemical binding]; other site
261292008428	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
261292008429	active site
261292008430	NTP binding site [chemical binding]; other site
261292008431	metal binding triad [ion binding]; metal-binding site
261292008432	antibiotic binding site [chemical binding]; other site
261292008433	Uncharacterized conserved protein [Function unknown]; Region: COG2361
261292008434	Helix-turn-helix domain; Region: HTH_28; pfam13518
261292008435	Winged helix-turn helix; Region: HTH_29; pfam13551
261292008436	Winged helix-turn helix; Region: HTH_33; pfam13592
261292008437	DDE superfamily endonuclease; Region: DDE_3; pfam13358
261292008438	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
261292008439	exonuclease I; Provisional; Region: sbcB; PRK11779
261292008440	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
261292008441	active site
261292008442	catalytic site [active]
261292008443	substrate binding site [chemical binding]; other site
261292008444	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
261292008445	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
261292008446	homotrimer interaction site [polypeptide binding]; other site
261292008447	putative active site [active]
261292008448	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
261292008449	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
261292008450	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
261292008451	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
261292008452	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
261292008453	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
261292008454	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
261292008455	Secretin and TonB N terminus short domain; Region: STN; smart00965
261292008456	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
261292008457	Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606
261292008458	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
261292008459	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
261292008460	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
261292008461	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
261292008462	Walker A motif; other site
261292008463	ATP binding site [chemical binding]; other site
261292008464	Walker B motif; other site
261292008465	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
261292008466	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
261292008467	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
261292008468	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
261292008469	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
261292008470	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
261292008471	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049
261292008472	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
261292008473	MASE1; Region: MASE1; pfam05231
261292008474	PAS domain S-box; Region: sensory_box; TIGR00229
261292008475	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292008476	putative active site [active]
261292008477	heme pocket [chemical binding]; other site
261292008478	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
261292008479	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292008480	putative active site [active]
261292008481	heme pocket [chemical binding]; other site
261292008482	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292008483	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
261292008484	putative active site [active]
261292008485	heme pocket [chemical binding]; other site
261292008486	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292008487	putative active site [active]
261292008488	heme pocket [chemical binding]; other site
261292008489	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
261292008490	dimer interface [polypeptide binding]; other site
261292008491	phosphorylation site [posttranslational modification]
261292008492	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292008493	ATP binding site [chemical binding]; other site
261292008494	Mg2+ binding site [ion binding]; other site
261292008495	G-X-G motif; other site
261292008496	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
261292008497	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
261292008498	active site
261292008499	phosphorylation site [posttranslational modification]
261292008500	intermolecular recognition site; other site
261292008501	dimerization interface [polypeptide binding]; other site
261292008502	Response regulator receiver domain; Region: Response_reg; pfam00072
261292008503	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292008504	active site
261292008505	phosphorylation site [posttranslational modification]
261292008506	intermolecular recognition site; other site
261292008507	dimerization interface [polypeptide binding]; other site
261292008508	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
261292008509	CPxP  motif; other site
261292008510	peptidase PmbA; Provisional; Region: PRK11040
261292008511	hypothetical protein; Provisional; Region: PRK05255
261292008512	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
261292008513	catalytic triad [active]
261292008514	putative active site [active]
261292008515	Ion channel; Region: Ion_trans_2; pfam07885
261292008516	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
261292008517	MASE1; Region: MASE1; pfam05231
261292008518	Major Facilitator Superfamily; Region: MFS_1; pfam07690
261292008519	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292008520	PAS fold; Region: PAS_3; pfam08447
261292008521	putative active site [active]
261292008522	heme pocket [chemical binding]; other site
261292008523	PAS fold; Region: PAS_3; pfam08447
261292008524	PAS domain; Region: PAS; smart00091
261292008525	PAS fold; Region: PAS_4; pfam08448
261292008526	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292008527	PAS fold; Region: PAS_3; pfam08447
261292008528	putative active site [active]
261292008529	heme pocket [chemical binding]; other site
261292008530	PAS domain; Region: PAS_8; pfam13188
261292008531	PAS fold; Region: PAS_4; pfam08448
261292008532	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
261292008533	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
261292008534	metal binding site [ion binding]; metal-binding site
261292008535	active site
261292008536	I-site; other site
261292008537	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
261292008538	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
261292008539	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
261292008540	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
261292008541	Walker A/P-loop; other site
261292008542	ATP binding site [chemical binding]; other site
261292008543	Q-loop/lid; other site
261292008544	ABC transporter signature motif; other site
261292008545	Walker B; other site
261292008546	D-loop; other site
261292008547	H-loop/switch region; other site
261292008548	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
261292008549	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
261292008550	Walker A/P-loop; other site
261292008551	ATP binding site [chemical binding]; other site
261292008552	Q-loop/lid; other site
261292008553	ABC transporter signature motif; other site
261292008554	Walker B; other site
261292008555	D-loop; other site
261292008556	H-loop/switch region; other site
261292008557	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
261292008558	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
261292008559	FtsX-like permease family; Region: FtsX; pfam02687
261292008560	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
261292008561	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
261292008562	ligand binding site [chemical binding]; other site
261292008563	flexible hinge region; other site
261292008564	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
261292008565	putative switch regulator; other site
261292008566	non-specific DNA interactions [nucleotide binding]; other site
261292008567	DNA binding site [nucleotide binding]
261292008568	sequence specific DNA binding site [nucleotide binding]; other site
261292008569	putative cAMP binding site [chemical binding]; other site
261292008570	Transposase domain (DUF772); Region: DUF772; pfam05598
261292008571	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
261292008572	Response regulator receiver domain; Region: Response_reg; pfam00072
261292008573	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292008574	active site
261292008575	phosphorylation site [posttranslational modification]
261292008576	intermolecular recognition site; other site
261292008577	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
261292008578	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
261292008579	multidrug resistance protein MdtN; Provisional; Region: PRK10476
261292008580	HlyD family secretion protein; Region: HlyD_3; pfam13437
261292008581	Outer membrane efflux protein; Region: OEP; pfam02321
261292008582	Outer membrane efflux protein; Region: OEP; pfam02321
261292008583	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
261292008584	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
261292008585	DXD motif; other site
261292008586	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
261292008587	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
261292008588	active site
261292008589	catalytic residues [active]
261292008590	Putative zinc-finger; Region: zf-HC2; pfam13490
261292008591	RNA polymerase sigma factor; Provisional; Region: PRK12515
261292008592	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
261292008593	DNA binding residues [nucleotide binding]
261292008594	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
261292008595	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
261292008596	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
261292008597	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
261292008598	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
261292008599	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
261292008600	Adenovirus IVa2 protein; Region: Adeno_IVa2; pfam02456
261292008601	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
261292008602	Walker A/P-loop; other site
261292008603	ATP binding site [chemical binding]; other site
261292008604	Q-loop/lid; other site
261292008605	ABC transporter signature motif; other site
261292008606	Walker B; other site
261292008607	D-loop; other site
261292008608	H-loop/switch region; other site
261292008609	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
261292008610	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
261292008611	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865
261292008612	putative hydrophobic ligand binding site [chemical binding]; other site
261292008613	O-methyltransferase; Region: Methyltransf_2; pfam00891
261292008614	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
261292008615	G1 box; other site
261292008616	GTP/Mg2+ binding site [chemical binding]; other site
261292008617	G2 box; other site
261292008618	Switch I region; other site
261292008619	G3 box; other site
261292008620	Switch II region; other site
261292008621	G4 box; other site
261292008622	Domain of unknown function (DUF3482); Region: DUF3482; pfam11981
261292008623	G5 box; other site
261292008624	Protein of unknown function (DUF2868); Region: DUF2868; pfam11067
261292008625	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
261292008626	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
261292008627	catalytic triad [active]
261292008628	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
261292008629	Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910
261292008630	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
261292008631	AAA ATPase domain; Region: AAA_16; pfam13191
261292008632	Uncharacterized conserved protein [Function unknown]; Region: COG1262
261292008633	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
261292008634	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964
261292008635	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
261292008636	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
261292008637	putative active site [active]
261292008638	putative metal binding site [ion binding]; other site
261292008639	Dicarboxylate transport; Region: DctA-YdbH; pfam11739
261292008640	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
261292008641	Protein of unknown function (DUF1318); Region: DUF1318; cl01547
261292008642	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
261292008643	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
261292008644	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
261292008645	active site
261292008646	NTP binding site [chemical binding]; other site
261292008647	metal binding triad [ion binding]; metal-binding site
261292008648	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
261292008649	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
261292008650	Zn2+ binding site [ion binding]; other site
261292008651	Mg2+ binding site [ion binding]; other site
261292008652	lytic murein transglycosylase; Provisional; Region: PRK11619
261292008653	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
261292008654	N-acetyl-D-glucosamine binding site [chemical binding]; other site
261292008655	catalytic residue [active]
261292008656	glutamate dehydrogenase; Provisional; Region: PRK09414
261292008657	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
261292008658	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
261292008659	NAD(P) binding site [chemical binding]; other site
261292008660	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
261292008661	RHS Repeat; Region: RHS_repeat; pfam05593
261292008662	RHS Repeat; Region: RHS_repeat; pfam05593
261292008663	RHS Repeat; Region: RHS_repeat; pfam05593
261292008664	RHS Repeat; Region: RHS_repeat; pfam05593
261292008665	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
261292008666	RHS Repeat; Region: RHS_repeat; pfam05593
261292008667	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
261292008668	Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850
261292008669	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
261292008670	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
261292008671	dimerization interface [polypeptide binding]; other site
261292008672	Histidine kinase; Region: HisKA_3; pfam07730
261292008673	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
261292008674	ATP binding site [chemical binding]; other site
261292008675	Mg2+ binding site [ion binding]; other site
261292008676	G-X-G motif; other site
261292008677	MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937
261292008678	Nitrogen regulatory protein P-II; Region: P-II; cl00412
261292008679	Uncharacterized conserved protein [Function unknown]; Region: COG3189
261292008680	Transcriptional regulator [Transcription]; Region: LysR; COG0583
261292008681	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
261292008682	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
261292008683	putative effector binding pocket; other site
261292008684	dimerization interface [polypeptide binding]; other site
261292008685	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
261292008686	Protocatechuate 3,4-dioxygenase (3,4-PCD) catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and beta-subunit and an Fe3+ ion...; Region: 3,4-PCD; cd03459
261292008687	thioredoxin reductase; Provisional; Region: PRK10262
261292008688	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
261292008689	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
261292008690	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
261292008691	Smr domain; Region: Smr; pfam01713
261292008692	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
261292008693	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
261292008694	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
261292008695	catalytic triad [active]
261292008696	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
261292008697	Major Facilitator Superfamily; Region: MFS_1; pfam07690
261292008698	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
261292008699	Restriction endonuclease; Region: Mrr_cat; pfam04471
261292008700	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
261292008701	non-specific DNA binding site [nucleotide binding]; other site
261292008702	salt bridge; other site
261292008703	sequence-specific DNA binding site [nucleotide binding]; other site
261292008704	Domain of unknown function (DUF955); Region: DUF955; pfam06114
261292008705	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
261292008706	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
261292008707	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
261292008708	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
261292008709	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
261292008710	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
261292008711	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
261292008712	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
261292008713	Transposase; Region: HTH_Tnp_1; cl17663
261292008714	Uncharacterized conserved protein [Function unknown]; Region: COG1479
261292008715	Protein of unknown function DUF262; Region: DUF262; pfam03235
261292008716	Protein of unknown function DUF262; Region: DUF262; pfam03235
261292008717	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
261292008718	PIN domain; Region: PIN_3; cl17397
261292008719	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
261292008720	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
261292008721	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
261292008722	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
261292008723	putative active site [active]
261292008724	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
261292008725	IHF dimer interface [polypeptide binding]; other site
261292008726	IHF - DNA interface [nucleotide binding]; other site
261292008727	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713
261292008728	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
261292008729	Helix-turn-helix domain; Region: HTH_17; pfam12728
261292008730	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
261292008731	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
261292008732	active site
261292008733	DNA binding site [nucleotide binding]
261292008734	Int/Topo IB signature motif; other site
261292008735	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
261292008736	putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073
261292008737	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
261292008738	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
261292008739	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
261292008740	ATP binding site [chemical binding]; other site
261292008741	putative Mg++ binding site [ion binding]; other site
261292008742	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
261292008743	HsdM N-terminal domain; Region: HsdM_N; pfam12161
261292008744	Methyltransferase domain; Region: Methyltransf_26; pfam13659
261292008745	AAA ATPase domain; Region: AAA_16; pfam13191
261292008746	Walker A motif; other site
261292008747	ATP binding site [chemical binding]; other site
261292008748	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
261292008749	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
261292008750	hypothetical protein; Validated; Region: PRK00029
261292008751	Uncharacterized conserved protein [Function unknown]; Region: COG0397
261292008752	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
261292008753	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
261292008754	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
261292008755	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
261292008756	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
261292008757	ligand binding site [chemical binding]; other site
261292008758	homodimer interface [polypeptide binding]; other site
261292008759	NAD(P) binding site [chemical binding]; other site
261292008760	trimer interface B [polypeptide binding]; other site
261292008761	trimer interface A [polypeptide binding]; other site
261292008762	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
261292008763	putative binding surface; other site
261292008764	active site
261292008765	putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Validated; Region: PRK06567
261292008766	FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192
261292008767	FAD binding pocket [chemical binding]; other site
261292008768	FAD binding motif [chemical binding]; other site
261292008769	phosphate binding motif [ion binding]; other site
261292008770	beta-alpha-beta structure motif; other site
261292008771	NAD binding pocket [chemical binding]; other site
261292008772	Iron coordination center [ion binding]; other site
261292008773	Response regulator receiver domain; Region: Response_reg; pfam00072
261292008774	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292008775	active site
261292008776	phosphorylation site [posttranslational modification]
261292008777	intermolecular recognition site; other site
261292008778	dimerization interface [polypeptide binding]; other site
261292008779	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
261292008780	Response regulator receiver domain; Region: Response_reg; pfam00072
261292008781	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292008782	active site
261292008783	phosphorylation site [posttranslational modification]
261292008784	intermolecular recognition site; other site
261292008785	dimerization interface [polypeptide binding]; other site
261292008786	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
261292008787	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
261292008788	CysD dimerization site [polypeptide binding]; other site
261292008789	G1 box; other site
261292008790	putative GEF interaction site [polypeptide binding]; other site
261292008791	GTP/Mg2+ binding site [chemical binding]; other site
261292008792	Switch I region; other site
261292008793	G2 box; other site
261292008794	G3 box; other site
261292008795	Switch II region; other site
261292008796	G4 box; other site
261292008797	G5 box; other site
261292008798	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
261292008799	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
261292008800	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
261292008801	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
261292008802	Active Sites [active]
261292008803	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
261292008804	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
261292008805	Active Sites [active]
261292008806	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
261292008807	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
261292008808	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
261292008809	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
261292008810	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684
261292008811	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
261292008812	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
261292008813	substrate binding site [chemical binding]; other site
261292008814	dimerization interface [polypeptide binding]; other site
261292008815	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
261292008816	Protein of unknown function (DUF3293); Region: DUF3293; pfam11697
261292008817	Tim44-like domain; Region: Tim44; pfam04280
261292008818	Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933
261292008819	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
261292008820	serine O-acetyltransferase; Region: cysE; TIGR01172
261292008821	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
261292008822	trimer interface [polypeptide binding]; other site
261292008823	active site
261292008824	substrate binding site [chemical binding]; other site
261292008825	CoA binding site [chemical binding]; other site
261292008826	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
261292008827	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
261292008828	dimer interface [polypeptide binding]; other site
261292008829	pyridoxal 5'-phosphate binding site [chemical binding]; other site
261292008830	catalytic residue [active]
261292008831	Thrombospondin C-terminal region; Region: TSP_C; pfam05735
261292008832	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
261292008833	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
261292008834	dimer interface [polypeptide binding]; other site
261292008835	decamer (pentamer of dimers) interface [polypeptide binding]; other site
261292008836	catalytic triad [active]
261292008837	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167
261292008838	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
261292008839	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
261292008840	motif II; other site
261292008841	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
261292008842	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
261292008843	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
261292008844	catalytic core [active]
261292008845	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
261292008846	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
261292008847	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
261292008848	NnrS protein; Region: NnrS; pfam05940
261292008849	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
261292008850	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
261292008851	active site
261292008852	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
261292008853	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
261292008854	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
261292008855	Peptidase family M50; Region: Peptidase_M50; pfam02163
261292008856	active site
261292008857	putative substrate binding region [chemical binding]; other site
261292008858	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
261292008859	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
261292008860	active site
261292008861	HIGH motif; other site
261292008862	dimer interface [polypeptide binding]; other site
261292008863	KMSKS motif; other site
261292008864	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
261292008865	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
261292008866	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
261292008867	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
261292008868	active site
261292008869	dimerization interface [polypeptide binding]; other site
261292008870	PEP-CTERM motif; Region: VPEP; pfam07589
261292008871	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
261292008872	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292008873	active site
261292008874	phosphorylation site [posttranslational modification]
261292008875	intermolecular recognition site; other site
261292008876	dimerization interface [polypeptide binding]; other site
261292008877	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
261292008878	DNA binding residues [nucleotide binding]
261292008879	dimerization interface [polypeptide binding]; other site
261292008880	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
261292008881	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
261292008882	active site
261292008883	phosphorylation site [posttranslational modification]
261292008884	intermolecular recognition site; other site
261292008885	dimerization interface [polypeptide binding]; other site
261292008886	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
261292008887	DNA binding residues [nucleotide binding]
261292008888	dimerization interface [polypeptide binding]; other site
261292008889	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
261292008890	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
261292008891	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
261292008892	Uncharacterized conserved protein [Function unknown]; Region: COG3391
261292008893	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
261292008894	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
261292008895	Transposase [DNA replication, recombination, and repair]; Region: COG5433
261292008896	Transposase [DNA replication, recombination, and repair]; Region: COG5433
261292008897	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
261292008898	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
261292008899	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
261292008900	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
261292008901	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
261292008902	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
261292008903	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
261292008904	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
261292008905	quinone interaction residues [chemical binding]; other site
261292008906	active site
261292008907	catalytic residues [active]
261292008908	FMN binding site [chemical binding]; other site
261292008909	substrate binding site [chemical binding]; other site
261292008910	ferredoxin; Provisional; Region: PRK08764
261292008911	Putative Fe-S cluster; Region: FeS; pfam04060
261292008912	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
261292008913	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
261292008914	minor groove reading motif; other site
261292008915	helix-hairpin-helix signature motif; other site
261292008916	substrate binding pocket [chemical binding]; other site
261292008917	active site
261292008918	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
261292008919	Domain of unknown function (DUF1841); Region: DUF1841; pfam08897
261292008920	Cytochrome c553 [Energy production and conversion]; Region: COG2863
261292008921	Cytochrome c553 [Energy production and conversion]; Region: COG2863
261292008922	ABC transporter ATPase component; Reviewed; Region: PRK11147
261292008923	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
261292008924	Walker A/P-loop; other site
261292008925	ATP binding site [chemical binding]; other site
261292008926	Q-loop/lid; other site
261292008927	ABC transporter signature motif; other site
261292008928	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
261292008929	Walker B; other site
261292008930	D-loop; other site
261292008931	ABC transporter; Region: ABC_tran_2; pfam12848
261292008932	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
261292008933	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
261292008934	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
261292008935	putative dimer interface [polypeptide binding]; other site
261292008936	Protein of unknown function DUF45; Region: DUF45; pfam01863
261292008937	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
261292008938	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
261292008939	putative acyl-acceptor binding pocket; other site
261292008940	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
261292008941	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
261292008942	active site
261292008943	motif I; other site
261292008944	motif II; other site
261292008945	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
261292008946	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
261292008947	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
261292008948	dimer interface [polypeptide binding]; other site
261292008949	motif 1; other site
261292008950	active site
261292008951	motif 2; other site
261292008952	motif 3; other site
261292008953	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
261292008954	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
261292008955	putative active site [active]
261292008956	catalytic triad [active]
261292008957	putative dimer interface [polypeptide binding]; other site
261292008958	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
261292008959	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
261292008960	binding surface
261292008961	TPR motif; other site
261292008962	TPR repeat; Region: TPR_11; pfam13414
261292008963	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
261292008964	binding surface
261292008965	TPR motif; other site
261292008966	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
261292008967	septum formation inhibitor; Reviewed; Region: minC; PRK00339
261292008968	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
261292008969	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
261292008970	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
261292008971	Switch I; other site
261292008972	Switch II; other site
261292008973	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
261292008974	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
261292008975	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
261292008976	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
261292008977	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
261292008978	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
261292008979	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
261292008980	active site
261292008981	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
261292008982	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
261292008983	5S rRNA interface [nucleotide binding]; other site
261292008984	CTC domain interface [polypeptide binding]; other site
261292008985	L16 interface [polypeptide binding]; other site
261292008986	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
261292008987	putative active site [active]
261292008988	catalytic residue [active]
261292008989	GTP-binding protein YchF; Reviewed; Region: PRK09601
261292008990	YchF GTPase; Region: YchF; cd01900
261292008991	G1 box; other site
261292008992	GTP/Mg2+ binding site [chemical binding]; other site
261292008993	Switch I region; other site
261292008994	G2 box; other site
261292008995	Switch II region; other site
261292008996	G3 box; other site
261292008997	G4 box; other site
261292008998	G5 box; other site
261292008999	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
261292009000	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
261292009001	Fic family protein [Function unknown]; Region: COG3177
261292009002	Fic/DOC family; Region: Fic; pfam02661
261292009003	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
261292009004	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
261292009005	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
261292009006	This entry represents the putative helicase A859L; Region: T5orf172; smart00974
261292009007	DEAD-like helicases superfamily; Region: DEXDc; smart00487
261292009008	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
261292009009	GIY-YIG motif/motif A; other site
261292009010	putative active site [active]
261292009011	putative metal binding site [ion binding]; other site
261292009012	ATP-dependent helicase HepA; Validated; Region: PRK04914
261292009013	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
261292009014	ATP binding site [chemical binding]; other site
261292009015	putative Mg++ binding site [ion binding]; other site
261292009016	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
261292009017	nucleotide binding region [chemical binding]; other site
261292009018	ATP-binding site [chemical binding]; other site
261292009019	Protein of unknown function (DUF2490); Region: DUF2490; pfam10677
261292009020	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
261292009021	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
261292009022	HemN C-terminal domain; Region: HemN_C; pfam06969
261292009023	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
261292009024	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
261292009025	ligand binding site [chemical binding]; other site
261292009026	flexible hinge region; other site
261292009027	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
261292009028	putative switch regulator; other site
261292009029	non-specific DNA interactions [nucleotide binding]; other site
261292009030	DNA binding site [nucleotide binding]
261292009031	sequence specific DNA binding site [nucleotide binding]; other site
261292009032	putative cAMP binding site [chemical binding]; other site
261292009033	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
261292009034	rRNA interaction site [nucleotide binding]; other site
261292009035	S8 interaction site; other site
261292009036	putative laminin-1 binding site; other site
261292009037	elongation factor Ts; Provisional; Region: tsf; PRK09377
261292009038	UBA/TS-N domain; Region: UBA; pfam00627
261292009039	Elongation factor TS; Region: EF_TS; pfam00889
261292009040	Elongation factor TS; Region: EF_TS; pfam00889
261292009041	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
261292009042	putative nucleotide binding site [chemical binding]; other site
261292009043	uridine monophosphate binding site [chemical binding]; other site
261292009044	homohexameric interface [polypeptide binding]; other site
261292009045	ribosome recycling factor; Reviewed; Region: frr; PRK00083
261292009046	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
261292009047	hinge region; other site
261292009048	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
261292009049	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
261292009050	catalytic residue [active]
261292009051	putative FPP diphosphate  binding site; other site
261292009052	putative FPP binding hydrophobic cleft; other site
261292009053	dimer interface [polypeptide binding]; other site
261292009054	putative IPP diphosphate binding site; other site
261292009055	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
261292009056	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
261292009057	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
261292009058	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
261292009059	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
261292009060	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
261292009061	zinc metallopeptidase RseP; Provisional; Region: PRK10779
261292009062	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
261292009063	active site
261292009064	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
261292009065	protein binding site [polypeptide binding]; other site
261292009066	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
261292009067	protein binding site [polypeptide binding]; other site
261292009068	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
261292009069	putative substrate binding region [chemical binding]; other site
261292009070	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
261292009071	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
261292009072	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
261292009073	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
261292009074	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
261292009075	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
261292009076	Surface antigen; Region: Bac_surface_Ag; pfam01103
261292009077	periplasmic chaperone; Provisional; Region: PRK10780
261292009078	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
261292009079	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
261292009080	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
261292009081	RNA/DNA hybrid binding site [nucleotide binding]; other site
261292009082	active site
261292009083	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
261292009084	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
261292009085	MutS domain I; Region: MutS_I; pfam01624
261292009086	MutS domain II; Region: MutS_II; pfam05188
261292009087	MutS domain III; Region: MutS_III; pfam05192
261292009088	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
261292009089	Walker A/P-loop; other site
261292009090	ATP binding site [chemical binding]; other site
261292009091	Q-loop/lid; other site
261292009092	ABC transporter signature motif; other site
261292009093	Walker B; other site
261292009094	D-loop; other site
261292009095	H-loop/switch region; other site
261292009096	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
261292009097	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
261292009098	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
261292009099	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
261292009100	active site
261292009101	Zn binding site [ion binding]; other site
261292009102	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
261292009103	active site residue [active]
261292009104	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
261292009105	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
261292009106	RNA binding surface [nucleotide binding]; other site
261292009107	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
261292009108	active site
261292009109	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
261292009110	S-adenosylmethionine binding site [chemical binding]; other site
261292009111	Methyltransferase domain; Region: Methyltransf_31; pfam13847
261292009112	Protein of unknown function (DUF2835); Region: DUF2835; pfam11197
261292009113	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
261292009114	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
261292009115	Walker A/P-loop; other site
261292009116	ATP binding site [chemical binding]; other site
261292009117	Q-loop/lid; other site
261292009118	ABC transporter signature motif; other site
261292009119	Walker B; other site
261292009120	D-loop; other site
261292009121	H-loop/switch region; other site
261292009122	ABC transporter; Region: ABC_tran_2; pfam12848
261292009123	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
261292009124	Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710
261292009125	Predicted ATPase [General function prediction only]; Region: COG4637
261292009126	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
261292009127	Walker A/P-loop; other site
261292009128	ATP binding site [chemical binding]; other site
261292009129	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
261292009130	Q-loop/lid; other site
261292009131	ABC transporter signature motif; other site
261292009132	Walker B; other site
261292009133	D-loop; other site
261292009134	H-loop/switch region; other site
261292009135	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
261292009136	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
261292009137	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
261292009138	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
261292009139	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
261292009140	ligand binding site [chemical binding]; other site
261292009141	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
261292009142	ligand binding site [chemical binding]; other site
261292009143	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
261292009144	Protein of unknown function (DUF454); Region: DUF454; pfam04304
261292009145	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292009146	PAS fold; Region: PAS_3; pfam08447
261292009147	putative active site [active]
261292009148	heme pocket [chemical binding]; other site
261292009149	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
261292009150	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
261292009151	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
261292009152	dimer interface [polypeptide binding]; other site
261292009153	putative CheW interface [polypeptide binding]; other site
261292009154	Protein of unknown function (DUF3135); Region: DUF3135; pfam11333
261292009155	Uncharacterized conserved protein [Function unknown]; Region: COG5316
261292009156	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
261292009157	Hemerythrin; Region: Hemerythrin; cd12107
261292009158	Fe binding site [ion binding]; other site
261292009159	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
261292009160	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
261292009161	metal binding site [ion binding]; metal-binding site
261292009162	active site
261292009163	I-site; other site
261292009164	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
261292009165	putative active site [active]
261292009166	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
261292009167	catalytic core [active]
261292009168	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
261292009169	Fatty acid desaturase; Region: FA_desaturase; pfam00487
261292009170	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cd01060
261292009171	putative di-iron ligands [ion binding]; other site
261292009172	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
261292009173	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
261292009174	nucleotide binding site/active site [active]
261292009175	HIT family signature motif; other site
261292009176	catalytic residue [active]
261292009177	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
261292009178	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
261292009179	active site
261292009180	metal-binding site
261292009181	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
261292009182	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
261292009183	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
261292009184	catalytic residue [active]
261292009185	TIR domain; Region: TIR_2; pfam13676
261292009186	Tetratricopeptide repeat; Region: TPR_12; pfam13424
261292009187	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
261292009188	binding surface
261292009189	TPR motif; other site
261292009190	Tetratricopeptide repeat; Region: TPR_12; pfam13424
261292009191	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
261292009192	TrkA-N domain; Region: TrkA_N; pfam02254
261292009193	RyR domain; Region: RyR; pfam02026
261292009194	TIR domain; Region: TIR_2; pfam13676
261292009195	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
261292009196	Catalytic domain of Protein Kinases; Region: PKc; cd00180
261292009197	active site
261292009198	ATP binding site [chemical binding]; other site
261292009199	substrate binding site [chemical binding]; other site
261292009200	activation loop (A-loop); other site
261292009201	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
261292009202	active site
261292009203	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
261292009204	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
261292009205	phosphopeptide binding site; other site
261292009206	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
261292009207	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
261292009208	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
261292009209	endonuclease III; Region: ENDO3c; smart00478
261292009210	minor groove reading motif; other site
261292009211	helix-hairpin-helix signature motif; other site
261292009212	substrate binding pocket [chemical binding]; other site
261292009213	active site
261292009214	cell division protein MraZ; Reviewed; Region: PRK00326
261292009215	MraZ protein; Region: MraZ; pfam02381
261292009216	MraZ protein; Region: MraZ; pfam02381
261292009217	MraW methylase family; Region: Methyltransf_5; cl17771
261292009218	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
261292009219	Cell division protein FtsL; Region: FtsL; pfam04999
261292009220	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
261292009221	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
261292009222	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
261292009223	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
261292009224	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
261292009225	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
261292009226	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
261292009227	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
261292009228	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
261292009229	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
261292009230	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
261292009231	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
261292009232	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
261292009233	Mg++ binding site [ion binding]; other site
261292009234	putative catalytic motif [active]
261292009235	putative substrate binding site [chemical binding]; other site
261292009236	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006
261292009237	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
261292009238	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
261292009239	cell division protein FtsW; Region: ftsW; TIGR02614
261292009240	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
261292009241	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
261292009242	active site
261292009243	homodimer interface [polypeptide binding]; other site
261292009244	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
261292009245	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
261292009246	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
261292009247	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
261292009248	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
261292009249	FAD binding domain; Region: FAD_binding_4; pfam01565
261292009250	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
261292009251	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
261292009252	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
261292009253	ATP-grasp domain; Region: ATP-grasp_4; cl17255
261292009254	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
261292009255	Cell division protein FtsQ; Region: FtsQ; pfam03799
261292009256	cell division protein FtsA; Region: ftsA; TIGR01174
261292009257	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
261292009258	nucleotide binding site [chemical binding]; other site
261292009259	SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491
261292009260	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
261292009261	Cell division protein FtsA; Region: FtsA; pfam14450
261292009262	cell division protein FtsZ; Validated; Region: PRK09330
261292009263	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
261292009264	nucleotide binding site [chemical binding]; other site
261292009265	SulA interaction site; other site
261292009266	CheB methylesterase; Region: CheB_methylest; pfam01339
261292009267	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
261292009268	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
261292009269	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
261292009270	S-adenosylmethionine binding site [chemical binding]; other site
261292009271	K-box region; Region: K-box; pfam01486
261292009272	PAS domain; Region: PAS_10; pfam13596
261292009273	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
261292009274	putative active site [active]
261292009275	heme pocket [chemical binding]; other site
261292009276	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
261292009277	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
261292009278	ligand binding site [chemical binding]; other site
261292009279	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
261292009280	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
261292009281	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
261292009282	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
261292009283	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
261292009284	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
261292009285	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
261292009286	Transposase; Region: HTH_Tnp_1; cl17663
261292009287	Copper resistance protein D; Region: CopD; cl00563
261292009288	Copper resistance protein D; Region: CopD; pfam05425
261292009289	cytochrome c-550; Provisional; Region: psbV; cl17239
261292009290	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
261292009291	CopC domain; Region: CopC; pfam04234
261292009292	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
261292009293	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
261292009294	ThiC-associated domain; Region: ThiC-associated; pfam13667
261292009295	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
261292009296	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
261292009297	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
261292009298	S-adenosylmethionine binding site [chemical binding]; other site
261292009299	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
261292009300	Mechanosensitive ion channel porin domain; Region: MscS_porin; pfam12795
261292009301	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
261292009302	Mechanosensitive ion channel; Region: MS_channel; pfam00924
261292009303	poly(A) polymerase; Region: pcnB; TIGR01942
261292009304	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
261292009305	active site
261292009306	NTP binding site [chemical binding]; other site
261292009307	metal binding triad [ion binding]; metal-binding site
261292009308	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
261292009309	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
261292009310	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
261292009311	catalytic center binding site [active]
261292009312	ATP binding site [chemical binding]; other site
261292009313	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
261292009314	oligomerization interface [polypeptide binding]; other site
261292009315	active site
261292009316	metal binding site [ion binding]; metal-binding site
261292009317	pantoate--beta-alanine ligase; Region: panC; TIGR00018
261292009318	Pantoate-beta-alanine ligase; Region: PanC; cd00560
261292009319	active site
261292009320	ATP-binding site [chemical binding]; other site
261292009321	pantoate-binding site; other site
261292009322	HXXH motif; other site