-- dump date 20140619_164811 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1133849000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 1133849000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1133849000003 Walker A motif; other site 1133849000004 ATP binding site [chemical binding]; other site 1133849000005 Walker B motif; other site 1133849000006 arginine finger; other site 1133849000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1133849000008 DnaA box-binding interface [nucleotide binding]; other site 1133849000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 1133849000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1133849000011 putative DNA binding surface [nucleotide binding]; other site 1133849000012 dimer interface [polypeptide binding]; other site 1133849000013 beta-clamp/clamp loader binding surface; other site 1133849000014 beta-clamp/translesion DNA polymerase binding surface; other site 1133849000015 recombination protein F; Reviewed; Region: recF; PRK00064 1133849000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1133849000017 Walker A/P-loop; other site 1133849000018 ATP binding site [chemical binding]; other site 1133849000019 Q-loop/lid; other site 1133849000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849000021 ABC transporter signature motif; other site 1133849000022 Walker B; other site 1133849000023 D-loop; other site 1133849000024 H-loop/switch region; other site 1133849000025 hypothetical protein; Provisional; Region: PRK03195 1133849000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1133849000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849000028 ATP binding site [chemical binding]; other site 1133849000029 Mg2+ binding site [ion binding]; other site 1133849000030 G-X-G motif; other site 1133849000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1133849000032 anchoring element; other site 1133849000033 dimer interface [polypeptide binding]; other site 1133849000034 ATP binding site [chemical binding]; other site 1133849000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1133849000036 active site 1133849000037 putative metal-binding site [ion binding]; other site 1133849000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1133849000039 DNA gyrase subunit A; Validated; Region: PRK05560 1133849000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1133849000041 CAP-like domain; other site 1133849000042 active site 1133849000043 primary dimer interface [polypeptide binding]; other site 1133849000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1133849000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1133849000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1133849000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1133849000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1133849000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1133849000050 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1133849000051 haloalkane dehalogenase; Provisional; Region: PRK03204 1133849000052 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1133849000053 Predicted transcriptional regulators [Transcription]; Region: COG1733 1133849000054 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1133849000055 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 1133849000056 Predicted membrane protein [Function unknown]; Region: COG3619 1133849000057 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1133849000058 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1133849000059 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849000060 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849000061 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849000062 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1133849000063 Walker A/P-loop; other site 1133849000064 ATP binding site [chemical binding]; other site 1133849000065 Q-loop/lid; other site 1133849000066 ABC transporter signature motif; other site 1133849000067 Walker B; other site 1133849000068 D-loop; other site 1133849000069 H-loop/switch region; other site 1133849000070 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1133849000071 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1133849000072 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1133849000073 active site 1133849000074 Rhomboid family; Region: Rhomboid; pfam01694 1133849000075 putative septation inhibitor protein; Reviewed; Region: PRK00159 1133849000076 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1133849000077 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1133849000078 glutamine binding [chemical binding]; other site 1133849000079 catalytic triad [active] 1133849000080 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1133849000081 RibD C-terminal domain; Region: RibD_C; cl17279 1133849000082 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1133849000083 catalytic motif [active] 1133849000084 Zn binding site [ion binding]; other site 1133849000085 FOG: CBS domain [General function prediction only]; Region: COG0517 1133849000086 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1133849000087 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1133849000088 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1133849000089 active site 1133849000090 ATP binding site [chemical binding]; other site 1133849000091 substrate binding site [chemical binding]; other site 1133849000092 activation loop (A-loop); other site 1133849000093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1133849000094 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1133849000095 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1133849000096 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1133849000097 PASTA domain; Region: PASTA; smart00740 1133849000098 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1133849000099 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1133849000100 active site 1133849000101 ATP binding site [chemical binding]; other site 1133849000102 substrate binding site [chemical binding]; other site 1133849000103 activation loop (A-loop); other site 1133849000104 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1133849000105 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1133849000106 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1133849000107 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1133849000108 active site 1133849000109 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1133849000110 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1133849000111 phosphopeptide binding site; other site 1133849000112 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1133849000113 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1133849000114 phosphopeptide binding site; other site 1133849000115 Secretory lipase; Region: LIP; pfam03583 1133849000116 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1133849000117 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1133849000118 active site 1133849000119 FMN binding site [chemical binding]; other site 1133849000120 substrate binding site [chemical binding]; other site 1133849000121 putative catalytic residue [active] 1133849000122 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1133849000123 classical (c) SDRs; Region: SDR_c; cd05233 1133849000124 NAD(P) binding site [chemical binding]; other site 1133849000125 active site 1133849000126 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1133849000127 Integral membrane protein DUF95; Region: DUF95; pfam01944 1133849000128 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1133849000129 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1133849000130 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1133849000131 active site 1133849000132 purine riboside binding site [chemical binding]; other site 1133849000133 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1133849000134 Protein of unknown function DUF58; Region: DUF58; pfam01882 1133849000135 MoxR-like ATPases [General function prediction only]; Region: COG0714 1133849000136 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1133849000137 Walker A motif; other site 1133849000138 ATP binding site [chemical binding]; other site 1133849000139 Walker B motif; other site 1133849000140 arginine finger; other site 1133849000141 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1133849000142 TetR family transcriptional regulator; Provisional; Region: PRK14996 1133849000143 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849000144 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1133849000145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849000146 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1133849000147 dimerization interface [polypeptide binding]; other site 1133849000148 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1133849000149 cyclase homology domain; Region: CHD; cd07302 1133849000150 nucleotidyl binding site; other site 1133849000151 metal binding site [ion binding]; metal-binding site 1133849000152 dimer interface [polypeptide binding]; other site 1133849000153 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 1133849000154 Chorismate mutase type II; Region: CM_2; cl00693 1133849000155 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1133849000156 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1133849000157 active site 1133849000158 dimer interface [polypeptide binding]; other site 1133849000159 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1133849000160 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1133849000161 active site 1133849000162 FMN binding site [chemical binding]; other site 1133849000163 substrate binding site [chemical binding]; other site 1133849000164 3Fe-4S cluster binding site [ion binding]; other site 1133849000165 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1133849000166 domain interface; other site 1133849000167 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1133849000168 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1133849000169 Cutinase; Region: Cutinase; pfam01083 1133849000170 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1133849000171 catalytic core [active] 1133849000172 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 1133849000173 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1133849000174 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1133849000175 dimer interface [polypeptide binding]; other site 1133849000176 putative anticodon binding site; other site 1133849000177 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1133849000178 motif 1; other site 1133849000179 dimer interface [polypeptide binding]; other site 1133849000180 active site 1133849000181 motif 2; other site 1133849000182 motif 3; other site 1133849000183 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1133849000184 RNA binding surface [nucleotide binding]; other site 1133849000185 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1133849000186 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1133849000187 hydrophobic ligand binding site; other site 1133849000188 Copper resistance protein D; Region: CopD; pfam05425 1133849000189 CopC domain; Region: CopC; pfam04234 1133849000190 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1133849000191 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 1133849000192 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1133849000193 heat shock protein 90; Provisional; Region: PRK05218 1133849000194 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849000195 ATP binding site [chemical binding]; other site 1133849000196 Mg2+ binding site [ion binding]; other site 1133849000197 G-X-G motif; other site 1133849000198 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1133849000199 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849000200 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1133849000201 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849000202 NAD(P) binding site [chemical binding]; other site 1133849000203 active site 1133849000204 short chain dehydrogenase; Provisional; Region: PRK05872 1133849000205 classical (c) SDRs; Region: SDR_c; cd05233 1133849000206 NAD(P) binding site [chemical binding]; other site 1133849000207 active site 1133849000208 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849000209 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849000210 Predicted membrane protein [Function unknown]; Region: COG2119 1133849000211 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1133849000212 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1133849000213 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1133849000214 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1133849000215 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1133849000216 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1133849000217 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1133849000218 active site residue [active] 1133849000219 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 1133849000220 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1133849000221 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 1133849000222 putative active site [active] 1133849000223 catalytic site [active] 1133849000224 putative metal binding site [ion binding]; other site 1133849000225 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1133849000226 Ferritin-like domain; Region: Ferritin; pfam00210 1133849000227 ferroxidase diiron center [ion binding]; other site 1133849000228 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1133849000229 Ferritin-like domain; Region: Ferritin; pfam00210 1133849000230 ferroxidase diiron center [ion binding]; other site 1133849000231 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1133849000232 YCII-related domain; Region: YCII; cl00999 1133849000233 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1133849000234 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849000235 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1133849000236 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1133849000237 CAAX protease self-immunity; Region: Abi; pfam02517 1133849000238 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 1133849000239 prephenate dehydratase; Provisional; Region: PRK11898 1133849000240 Prephenate dehydratase; Region: PDT; pfam00800 1133849000241 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1133849000242 putative L-Phe binding site [chemical binding]; other site 1133849000243 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1133849000244 catalytic core [active] 1133849000245 EspG family; Region: ESX-1_EspG; pfam14011 1133849000246 PPE family; Region: PPE; pfam00823 1133849000247 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1133849000248 Septum formation; Region: Septum_form; pfam13845 1133849000249 Septum formation; Region: Septum_form; pfam13845 1133849000250 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1133849000251 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1133849000252 NAD(P) binding site [chemical binding]; other site 1133849000253 catalytic residues [active] 1133849000254 seryl-tRNA synthetase; Provisional; Region: PRK05431 1133849000255 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1133849000256 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1133849000257 dimer interface [polypeptide binding]; other site 1133849000258 active site 1133849000259 motif 1; other site 1133849000260 motif 2; other site 1133849000261 motif 3; other site 1133849000262 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1133849000263 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1133849000264 metal binding site [ion binding]; metal-binding site 1133849000265 active site 1133849000266 I-site; other site 1133849000267 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1133849000268 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1133849000269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849000270 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849000271 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849000272 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1133849000273 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849000274 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1133849000275 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849000276 S-adenosylmethionine binding site [chemical binding]; other site 1133849000277 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1133849000278 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1133849000279 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1133849000280 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1133849000281 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1133849000282 iron-sulfur cluster [ion binding]; other site 1133849000283 [2Fe-2S] cluster binding site [ion binding]; other site 1133849000284 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1133849000285 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1133849000286 putative acyl-acceptor binding pocket; other site 1133849000287 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1133849000288 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1133849000289 putative acyl-acceptor binding pocket; other site 1133849000290 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1133849000291 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1133849000292 metal-binding site [ion binding] 1133849000293 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1133849000294 YtkA-like; Region: YtkA; pfam13115 1133849000295 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1133849000296 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 1133849000297 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1133849000298 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1133849000299 DNA-binding site [nucleotide binding]; DNA binding site 1133849000300 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1133849000301 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1133849000302 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1133849000303 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1133849000304 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1133849000305 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1133849000306 Walker A/P-loop; other site 1133849000307 ATP binding site [chemical binding]; other site 1133849000308 Q-loop/lid; other site 1133849000309 ABC transporter signature motif; other site 1133849000310 Walker B; other site 1133849000311 D-loop; other site 1133849000312 H-loop/switch region; other site 1133849000313 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1133849000314 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1133849000315 Walker A/P-loop; other site 1133849000316 ATP binding site [chemical binding]; other site 1133849000317 Q-loop/lid; other site 1133849000318 ABC transporter signature motif; other site 1133849000319 Walker B; other site 1133849000320 D-loop; other site 1133849000321 H-loop/switch region; other site 1133849000322 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1133849000323 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1133849000324 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1133849000325 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849000326 dimer interface [polypeptide binding]; other site 1133849000327 conserved gate region; other site 1133849000328 putative PBP binding loops; other site 1133849000329 ABC-ATPase subunit interface; other site 1133849000330 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1133849000331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849000332 dimer interface [polypeptide binding]; other site 1133849000333 conserved gate region; other site 1133849000334 putative PBP binding loops; other site 1133849000335 ABC-ATPase subunit interface; other site 1133849000336 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1133849000337 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1133849000338 TAP-like protein; Region: Abhydrolase_4; pfam08386 1133849000339 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1133849000340 Histidine kinase; Region: HisKA_3; pfam07730 1133849000341 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849000342 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849000343 active site 1133849000344 phosphorylation site [posttranslational modification] 1133849000345 intermolecular recognition site; other site 1133849000346 dimerization interface [polypeptide binding]; other site 1133849000347 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849000348 DNA binding residues [nucleotide binding] 1133849000349 dimerization interface [polypeptide binding]; other site 1133849000350 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1133849000351 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1133849000352 active site 1133849000353 motif I; other site 1133849000354 motif II; other site 1133849000355 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1133849000356 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1133849000357 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1133849000358 amidase catalytic site [active] 1133849000359 Zn binding residues [ion binding]; other site 1133849000360 substrate binding site [chemical binding]; other site 1133849000361 Stage II sporulation protein; Region: SpoIID; pfam08486 1133849000362 MarR family; Region: MarR_2; cl17246 1133849000363 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1133849000364 EamA-like transporter family; Region: EamA; pfam00892 1133849000365 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1133849000366 EamA-like transporter family; Region: EamA; pfam00892 1133849000367 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1133849000368 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1133849000369 DNA binding residues [nucleotide binding] 1133849000370 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1133849000371 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1133849000372 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1133849000373 UDP-galactopyranose mutase; Region: GLF; pfam03275 1133849000374 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1133849000375 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1133849000376 active site 1133849000377 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1133849000378 Predicted esterase [General function prediction only]; Region: COG0627 1133849000379 Putative esterase; Region: Esterase; pfam00756 1133849000380 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1133849000381 Putative esterase; Region: Esterase; pfam00756 1133849000382 Putative esterase; Region: Esterase; pfam00756 1133849000383 Putative esterase; Region: Esterase; pfam00756 1133849000384 S-formylglutathione hydrolase; Region: PLN02442 1133849000385 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1133849000386 LGFP repeat; Region: LGFP; pfam08310 1133849000387 LGFP repeat; Region: LGFP; pfam08310 1133849000388 LGFP repeat; Region: LGFP; pfam08310 1133849000389 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1133849000390 Cutinase; Region: Cutinase; pfam01083 1133849000391 Uncharacterized BCR, COG1636; Region: DUF208; cl17782 1133849000392 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 1133849000393 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1133849000394 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1133849000395 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1133849000396 acyl-activating enzyme (AAE) consensus motif; other site 1133849000397 active site 1133849000398 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1133849000399 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1133849000400 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1133849000401 active site 1133849000402 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1133849000403 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1133849000404 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1133849000405 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1133849000406 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1133849000407 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1133849000408 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1133849000409 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1133849000410 substrate binding site [chemical binding]; other site 1133849000411 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1133849000412 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1133849000413 putative active site [active] 1133849000414 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1133849000415 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 1133849000416 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 1133849000417 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1133849000418 classical (c) SDRs; Region: SDR_c; cd05233 1133849000419 NAD(P) binding site [chemical binding]; other site 1133849000420 active site 1133849000421 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1133849000422 FAD binding domain; Region: FAD_binding_4; pfam01565 1133849000423 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1133849000424 Predicted membrane protein [Function unknown]; Region: COG2246 1133849000425 GtrA-like protein; Region: GtrA; pfam04138 1133849000426 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1133849000427 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 1133849000428 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1133849000429 putative [Fe4-S4] binding site [ion binding]; other site 1133849000430 putative molybdopterin cofactor binding site [chemical binding]; other site 1133849000431 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1133849000432 putative molybdopterin cofactor binding site; other site 1133849000433 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 1133849000434 Helix-turn-helix domain; Region: HTH_31; pfam13560 1133849000435 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1133849000436 MarR family; Region: MarR_2; pfam12802 1133849000437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849000438 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1133849000439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849000440 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1133849000441 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1133849000442 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1133849000443 substrate binding site; other site 1133849000444 tetramer interface; other site 1133849000445 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1133849000446 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1133849000447 substrate binding pocket [chemical binding]; other site 1133849000448 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1133849000449 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1133849000450 NAD binding site [chemical binding]; other site 1133849000451 substrate binding site [chemical binding]; other site 1133849000452 homodimer interface [polypeptide binding]; other site 1133849000453 active site 1133849000454 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 1133849000455 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1133849000456 Ligand binding site; other site 1133849000457 Putative Catalytic site; other site 1133849000458 DXD motif; other site 1133849000459 Predicted membrane protein [Function unknown]; Region: COG2246 1133849000460 GtrA-like protein; Region: GtrA; pfam04138 1133849000461 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1133849000462 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1133849000463 active site 1133849000464 short chain dehydrogenase; Provisional; Region: PRK08278 1133849000465 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849000466 NAD(P) binding site [chemical binding]; other site 1133849000467 active site 1133849000468 GTPase RsgA; Reviewed; Region: PRK01889 1133849000469 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1133849000470 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1133849000471 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1133849000472 GTP/Mg2+ binding site [chemical binding]; other site 1133849000473 G4 box; other site 1133849000474 G5 box; other site 1133849000475 G1 box; other site 1133849000476 Switch I region; other site 1133849000477 G2 box; other site 1133849000478 G3 box; other site 1133849000479 Switch II region; other site 1133849000480 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1133849000481 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1133849000482 active site 1133849000483 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1133849000484 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1133849000485 Walker A/P-loop; other site 1133849000486 ATP binding site [chemical binding]; other site 1133849000487 Q-loop/lid; other site 1133849000488 ABC transporter signature motif; other site 1133849000489 Walker B; other site 1133849000490 D-loop; other site 1133849000491 H-loop/switch region; other site 1133849000492 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1133849000493 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1133849000494 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 1133849000495 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1133849000496 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1133849000497 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849000498 catalytic residue [active] 1133849000499 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1133849000500 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1133849000501 NAD(P) binding site [chemical binding]; other site 1133849000502 MarR family; Region: MarR_2; cl17246 1133849000503 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1133849000504 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1133849000505 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1133849000506 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 1133849000507 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1133849000508 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1133849000509 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1133849000510 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849000511 homodimer interface [polypeptide binding]; other site 1133849000512 catalytic residue [active] 1133849000513 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1133849000514 Putative esterase; Region: Esterase; pfam00756 1133849000515 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cl00254 1133849000516 active site 1133849000517 dimer interface [polypeptide binding]; other site 1133849000518 DoxX-like family; Region: DoxX_2; pfam13564 1133849000519 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1133849000520 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1133849000521 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1133849000522 DinB superfamily; Region: DinB_2; pfam12867 1133849000523 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 1133849000524 homotrimer interaction site [polypeptide binding]; other site 1133849000525 putative active site [active] 1133849000526 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1133849000527 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1133849000528 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1133849000529 mismatch recognition site; other site 1133849000530 additional DNA contacts [nucleotide binding]; other site 1133849000531 active site 1133849000532 zinc binding site [ion binding]; other site 1133849000533 DNA intercalation site [nucleotide binding]; other site 1133849000534 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1133849000535 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 1133849000536 cofactor binding site; other site 1133849000537 DNA binding site [nucleotide binding] 1133849000538 substrate interaction site [chemical binding]; other site 1133849000539 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1133849000540 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1133849000541 dimer interface [polypeptide binding]; other site 1133849000542 active site 1133849000543 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1133849000544 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1133849000545 acyl-activating enzyme (AAE) consensus motif; other site 1133849000546 active site 1133849000547 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1133849000548 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1133849000549 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849000550 Walker A/P-loop; other site 1133849000551 ATP binding site [chemical binding]; other site 1133849000552 Q-loop/lid; other site 1133849000553 ABC transporter signature motif; other site 1133849000554 Walker B; other site 1133849000555 D-loop; other site 1133849000556 H-loop/switch region; other site 1133849000557 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1133849000558 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1133849000559 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849000560 Walker A/P-loop; other site 1133849000561 ATP binding site [chemical binding]; other site 1133849000562 Q-loop/lid; other site 1133849000563 ABC transporter signature motif; other site 1133849000564 Walker B; other site 1133849000565 D-loop; other site 1133849000566 H-loop/switch region; other site 1133849000567 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 1133849000568 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 1133849000569 prephenate dehydrogenase; Validated; Region: PRK08507 1133849000570 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1133849000571 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1133849000572 dimer interface [polypeptide binding]; other site 1133849000573 catalytic motif [active] 1133849000574 nucleoside/Zn binding site; other site 1133849000575 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849000576 non-specific DNA binding site [nucleotide binding]; other site 1133849000577 salt bridge; other site 1133849000578 sequence-specific DNA binding site [nucleotide binding]; other site 1133849000579 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 1133849000580 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1133849000581 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1133849000582 DNA binding residues [nucleotide binding] 1133849000583 dimer interface [polypeptide binding]; other site 1133849000584 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1133849000585 Predicted transcriptional regulators [Transcription]; Region: COG1733 1133849000586 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1133849000587 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1133849000588 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849000589 NAD(P) binding site [chemical binding]; other site 1133849000590 active site 1133849000591 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1133849000592 MMPL family; Region: MMPL; pfam03176 1133849000593 MMPL family; Region: MMPL; pfam03176 1133849000594 MMPL family; Region: MMPL; pfam03176 1133849000595 MMPL family; Region: MMPL; pfam03176 1133849000596 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849000597 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849000598 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 1133849000599 Predicted transcriptional regulator [Transcription]; Region: COG1959 1133849000600 Transcriptional regulator; Region: Rrf2; pfam02082 1133849000601 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1133849000602 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1133849000603 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849000604 Walker A/P-loop; other site 1133849000605 ATP binding site [chemical binding]; other site 1133849000606 Q-loop/lid; other site 1133849000607 ABC transporter signature motif; other site 1133849000608 Walker B; other site 1133849000609 D-loop; other site 1133849000610 H-loop/switch region; other site 1133849000611 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1133849000612 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1133849000613 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1133849000614 Walker A/P-loop; other site 1133849000615 ATP binding site [chemical binding]; other site 1133849000616 Q-loop/lid; other site 1133849000617 ABC transporter signature motif; other site 1133849000618 Walker B; other site 1133849000619 D-loop; other site 1133849000620 H-loop/switch region; other site 1133849000621 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1133849000622 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1133849000623 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 1133849000624 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1133849000625 RDD family; Region: RDD; pfam06271 1133849000626 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1133849000627 active site 1133849000628 HIGH motif; other site 1133849000629 nucleotide binding site [chemical binding]; other site 1133849000630 active site 1133849000631 KMSKS motif; other site 1133849000632 Domain of unknown function (DUF309); Region: DUF309; pfam03745 1133849000633 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1133849000634 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1133849000635 heme bH binding site [chemical binding]; other site 1133849000636 Qi binding site; other site 1133849000637 intrachain domain interface; other site 1133849000638 heme bL binding site [chemical binding]; other site 1133849000639 interchain domain interface [polypeptide binding]; other site 1133849000640 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1133849000641 Qo binding site; other site 1133849000642 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1133849000643 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1133849000644 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849000645 S-adenosylmethionine binding site [chemical binding]; other site 1133849000646 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1133849000647 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1133849000648 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1133849000649 active site 1133849000650 ATP binding site [chemical binding]; other site 1133849000651 substrate binding site [chemical binding]; other site 1133849000652 activation loop (A-loop); other site 1133849000653 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1133849000654 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1133849000655 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1133849000656 TIGR03086 family protein; Region: TIGR03086 1133849000657 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849000658 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849000659 Cytochrome P450; Region: p450; cl12078 1133849000660 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1133849000661 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1133849000662 Domain of unknown function (DUF385); Region: DUF385; cl04387 1133849000663 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1133849000664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849000665 S-adenosylmethionine binding site [chemical binding]; other site 1133849000666 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849000667 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849000668 DNA binding residues [nucleotide binding] 1133849000669 dimerization interface [polypeptide binding]; other site 1133849000670 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849000671 Cytochrome P450; Region: p450; cl12078 1133849000672 HEAT repeats; Region: HEAT_2; pfam13646 1133849000673 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1133849000674 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1133849000675 Secretory lipase; Region: LIP; pfam03583 1133849000676 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 1133849000677 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1133849000678 Trp docking motif [polypeptide binding]; other site 1133849000679 active site 1133849000680 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1133849000681 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1133849000682 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849000683 catalytic residue [active] 1133849000684 hypothetical protein; Provisional; Region: PRK08317 1133849000685 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1133849000686 S-adenosylmethionine binding site [chemical binding]; other site 1133849000687 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1133849000688 minor groove reading motif; other site 1133849000689 helix-hairpin-helix signature motif; other site 1133849000690 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1133849000691 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1133849000692 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1133849000693 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1133849000694 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849000695 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849000696 WHG domain; Region: WHG; pfam13305 1133849000697 MMPL family; Region: MMPL; pfam03176 1133849000698 MMPL family; Region: MMPL; pfam03176 1133849000699 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1133849000700 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1133849000701 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1133849000702 Walker A motif; other site 1133849000703 ATP binding site [chemical binding]; other site 1133849000704 Walker B motif; other site 1133849000705 arginine finger; other site 1133849000706 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1133849000707 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1133849000708 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1133849000709 dimer interface [polypeptide binding]; other site 1133849000710 active site 1133849000711 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1133849000712 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1133849000713 substrate binding site [chemical binding]; other site 1133849000714 oxyanion hole (OAH) forming residues; other site 1133849000715 trimer interface [polypeptide binding]; other site 1133849000716 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1133849000717 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1133849000718 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1133849000719 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1133849000720 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1133849000721 active site 1133849000722 ATP binding site [chemical binding]; other site 1133849000723 substrate binding site [chemical binding]; other site 1133849000724 activation loop (A-loop); other site 1133849000725 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1133849000726 AAA ATPase domain; Region: AAA_16; pfam13191 1133849000727 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1133849000728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849000729 S-adenosylmethionine binding site [chemical binding]; other site 1133849000730 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1133849000731 FAD binding domain; Region: FAD_binding_4; pfam01565 1133849000732 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1133849000733 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1133849000734 active site 1133849000735 metal binding site [ion binding]; metal-binding site 1133849000736 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1133849000737 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1133849000738 DNA binding residues [nucleotide binding] 1133849000739 drug binding residues [chemical binding]; other site 1133849000740 dimer interface [polypeptide binding]; other site 1133849000741 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1133849000742 hypothetical protein; Validated; Region: PRK00153 1133849000743 recombination protein RecR; Reviewed; Region: recR; PRK00076 1133849000744 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1133849000745 RecR protein; Region: RecR; pfam02132 1133849000746 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1133849000747 putative active site [active] 1133849000748 putative metal-binding site [ion binding]; other site 1133849000749 tetramer interface [polypeptide binding]; other site 1133849000750 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1133849000751 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1133849000752 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1133849000753 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1133849000754 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 1133849000755 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 1133849000756 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 1133849000757 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1133849000758 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1133849000759 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1133849000760 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1133849000761 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 1133849000762 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 1133849000763 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1133849000764 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1133849000765 Walker A/P-loop; other site 1133849000766 ATP binding site [chemical binding]; other site 1133849000767 Q-loop/lid; other site 1133849000768 ABC transporter signature motif; other site 1133849000769 Walker B; other site 1133849000770 D-loop; other site 1133849000771 H-loop/switch region; other site 1133849000772 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 1133849000773 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1133849000774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1133849000775 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1133849000776 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 1133849000777 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1133849000778 catalytic triad [active] 1133849000779 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1133849000780 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1133849000781 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 1133849000782 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1133849000783 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1133849000784 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1133849000785 EamA-like transporter family; Region: EamA; pfam00892 1133849000786 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1133849000787 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849000788 putative DNA binding site [nucleotide binding]; other site 1133849000789 dimerization interface [polypeptide binding]; other site 1133849000790 putative Zn2+ binding site [ion binding]; other site 1133849000791 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1133849000792 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1133849000793 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1133849000794 dimer interface [polypeptide binding]; other site 1133849000795 active site 1133849000796 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1133849000797 2-isopropylmalate synthase; Validated; Region: PRK03739 1133849000798 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1133849000799 active site 1133849000800 catalytic residues [active] 1133849000801 metal binding site [ion binding]; metal-binding site 1133849000802 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1133849000803 hypothetical protein; Provisional; Region: PRK10621 1133849000804 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1133849000805 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849000806 TAP-like protein; Region: Abhydrolase_4; pfam08386 1133849000807 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1133849000808 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1133849000809 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1133849000810 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1133849000811 hydrophobic ligand binding site; other site 1133849000812 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 1133849000813 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849000814 RibD C-terminal domain; Region: RibD_C; cl17279 1133849000815 RibD C-terminal domain; Region: RibD_C; cl17279 1133849000816 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1133849000817 CGNR zinc finger; Region: zf-CGNR; pfam11706 1133849000818 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 1133849000819 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1133849000820 MarR family; Region: MarR_2; cl17246 1133849000821 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 1133849000822 aspartate kinase; Reviewed; Region: PRK06635 1133849000823 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1133849000824 putative nucleotide binding site [chemical binding]; other site 1133849000825 putative catalytic residues [active] 1133849000826 putative Mg ion binding site [ion binding]; other site 1133849000827 putative aspartate binding site [chemical binding]; other site 1133849000828 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1133849000829 putative allosteric regulatory site; other site 1133849000830 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1133849000831 putative allosteric regulatory residue; other site 1133849000832 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1133849000833 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1133849000834 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1133849000835 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1133849000836 PA14 domain; Region: PA14; cl08459 1133849000837 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1133849000838 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1133849000839 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849000840 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849000841 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1133849000842 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1133849000843 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1133849000844 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1133849000845 tetramer interface [polypeptide binding]; other site 1133849000846 heme binding pocket [chemical binding]; other site 1133849000847 NADPH binding site [chemical binding]; other site 1133849000848 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1133849000849 metal binding site 2 [ion binding]; metal-binding site 1133849000850 putative DNA binding helix; other site 1133849000851 metal binding site 1 [ion binding]; metal-binding site 1133849000852 dimer interface [polypeptide binding]; other site 1133849000853 structural Zn2+ binding site [ion binding]; other site 1133849000854 Beta-lactamase; Region: Beta-lactamase; pfam00144 1133849000855 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1133849000856 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1133849000857 Beta-lactamase; Region: Beta-lactamase; pfam00144 1133849000858 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849000859 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1133849000860 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849000861 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1133849000862 putative substrate translocation pore; other site 1133849000863 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849000864 Cytochrome P450; Region: p450; cl12078 1133849000865 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849000866 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849000867 hypothetical protein; Provisional; Region: PRK07236 1133849000868 hypothetical protein; Provisional; Region: PRK07588 1133849000869 allophanate hydrolase; Provisional; Region: PRK08186 1133849000870 Amidase; Region: Amidase; cl11426 1133849000871 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 1133849000872 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1133849000873 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1133849000874 DNA-binding site [nucleotide binding]; DNA binding site 1133849000875 FCD domain; Region: FCD; pfam07729 1133849000876 Fic family protein [Function unknown]; Region: COG3177 1133849000877 Fic/DOC family; Region: Fic; pfam02661 1133849000878 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1133849000879 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1133849000880 Coenzyme A binding pocket [chemical binding]; other site 1133849000881 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1133849000882 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849000883 NAD(P) binding site [chemical binding]; other site 1133849000884 active site 1133849000885 Predicted membrane protein [Function unknown]; Region: COG2311 1133849000886 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1133849000887 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849000888 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1133849000889 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1133849000890 putative active site [active] 1133849000891 Topoisomerase II-associated protein PAT1; Region: PAT1; pfam09770 1133849000892 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1133849000893 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1133849000894 putative active site [active] 1133849000895 putative metal binding site [ion binding]; other site 1133849000896 Yqey-like protein; Region: YqeY; pfam09424 1133849000897 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1133849000898 Transglycosylase; Region: Transgly; pfam00912 1133849000899 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1133849000900 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1133849000901 Transcription factor WhiB; Region: Whib; pfam02467 1133849000902 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1133849000903 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1133849000904 DTAP/Switch II; other site 1133849000905 Switch I; other site 1133849000906 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1133849000907 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1133849000908 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1133849000909 P loop; other site 1133849000910 Nucleotide binding site [chemical binding]; other site 1133849000911 DTAP/Switch II; other site 1133849000912 Switch I; other site 1133849000913 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1133849000914 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1133849000915 homotrimer interaction site [polypeptide binding]; other site 1133849000916 putative active site [active] 1133849000917 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1133849000918 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1133849000919 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1133849000920 ligand binding site [chemical binding]; other site 1133849000921 flexible hinge region; other site 1133849000922 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1133849000923 putative switch regulator; other site 1133849000924 non-specific DNA interactions [nucleotide binding]; other site 1133849000925 DNA binding site [nucleotide binding] 1133849000926 sequence specific DNA binding site [nucleotide binding]; other site 1133849000927 putative cAMP binding site [chemical binding]; other site 1133849000928 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1133849000929 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1133849000930 minor groove reading motif; other site 1133849000931 helix-hairpin-helix signature motif; other site 1133849000932 substrate binding pocket [chemical binding]; other site 1133849000933 active site 1133849000934 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1133849000935 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1133849000936 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1133849000937 catalytic residues [active] 1133849000938 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1133849000939 putative active site [active] 1133849000940 putative CoA binding site [chemical binding]; other site 1133849000941 nudix motif; other site 1133849000942 metal binding site [ion binding]; metal-binding site 1133849000943 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1133849000944 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849000945 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1133849000946 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1133849000947 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1133849000948 acetyl-CoA synthetase; Provisional; Region: PRK00174 1133849000949 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1133849000950 active site 1133849000951 CoA binding site [chemical binding]; other site 1133849000952 acyl-activating enzyme (AAE) consensus motif; other site 1133849000953 AMP binding site [chemical binding]; other site 1133849000954 acetate binding site [chemical binding]; other site 1133849000955 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1133849000956 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1133849000957 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1133849000958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849000959 dimer interface [polypeptide binding]; other site 1133849000960 conserved gate region; other site 1133849000961 putative PBP binding loops; other site 1133849000962 ABC-ATPase subunit interface; other site 1133849000963 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1133849000964 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1133849000965 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849000966 dimer interface [polypeptide binding]; other site 1133849000967 conserved gate region; other site 1133849000968 putative PBP binding loops; other site 1133849000969 ABC-ATPase subunit interface; other site 1133849000970 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1133849000971 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1133849000972 Walker A/P-loop; other site 1133849000973 ATP binding site [chemical binding]; other site 1133849000974 Q-loop/lid; other site 1133849000975 ABC transporter signature motif; other site 1133849000976 Walker B; other site 1133849000977 D-loop; other site 1133849000978 H-loop/switch region; other site 1133849000979 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1133849000980 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1133849000981 Walker A/P-loop; other site 1133849000982 ATP binding site [chemical binding]; other site 1133849000983 Q-loop/lid; other site 1133849000984 ABC transporter signature motif; other site 1133849000985 Walker B; other site 1133849000986 D-loop; other site 1133849000987 H-loop/switch region; other site 1133849000988 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1133849000989 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849000990 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1133849000991 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1133849000992 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1133849000993 MarR family; Region: MarR_2; pfam12802 1133849000994 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1133849000995 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1133849000996 motif II; other site 1133849000997 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1133849000998 Type II/IV secretion system protein; Region: T2SE; pfam00437 1133849000999 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1133849001000 hexamer interface [polypeptide binding]; other site 1133849001001 Walker B motif; other site 1133849001002 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1133849001003 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 1133849001004 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1133849001005 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1133849001006 ATP binding site [chemical binding]; other site 1133849001007 putative Mg++ binding site [ion binding]; other site 1133849001008 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1133849001009 nucleotide binding region [chemical binding]; other site 1133849001010 ATP-binding site [chemical binding]; other site 1133849001011 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1133849001012 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1133849001013 DNA-binding site [nucleotide binding]; DNA binding site 1133849001014 RNA-binding motif; other site 1133849001015 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1133849001016 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1133849001017 active site 1133849001018 interdomain interaction site; other site 1133849001019 putative metal-binding site [ion binding]; other site 1133849001020 nucleotide binding site [chemical binding]; other site 1133849001021 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1133849001022 domain I; other site 1133849001023 phosphate binding site [ion binding]; other site 1133849001024 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1133849001025 domain II; other site 1133849001026 domain III; other site 1133849001027 nucleotide binding site [chemical binding]; other site 1133849001028 DNA binding groove [nucleotide binding] 1133849001029 catalytic site [active] 1133849001030 domain IV; other site 1133849001031 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1133849001032 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1133849001033 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1133849001034 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1133849001035 DinB superfamily; Region: DinB_2; pfam12867 1133849001036 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 1133849001037 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1133849001038 conserved cys residue [active] 1133849001039 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1133849001040 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1133849001041 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 1133849001042 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1133849001043 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1133849001044 active site 1133849001045 DNA binding site [nucleotide binding] 1133849001046 Int/Topo IB signature motif; other site 1133849001047 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1133849001048 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1133849001049 putative active site [active] 1133849001050 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 1133849001051 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 1133849001052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1133849001053 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1133849001054 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1133849001055 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1133849001056 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1133849001057 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849001058 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1133849001059 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1133849001060 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1133849001061 Zn binding site [ion binding]; other site 1133849001062 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849001063 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1133849001064 acyl-activating enzyme (AAE) consensus motif; other site 1133849001065 AMP binding site [chemical binding]; other site 1133849001066 active site 1133849001067 CoA binding site [chemical binding]; other site 1133849001068 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849001069 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 1133849001070 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1133849001071 putative trimer interface [polypeptide binding]; other site 1133849001072 putative CoA binding site [chemical binding]; other site 1133849001073 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1133849001074 putative trimer interface [polypeptide binding]; other site 1133849001075 putative CoA binding site [chemical binding]; other site 1133849001076 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1133849001077 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1133849001078 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1133849001079 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849001080 catalytic residue [active] 1133849001081 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1133849001082 putative active site [active] 1133849001083 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1133849001084 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1133849001085 putative deacylase active site [active] 1133849001086 putative OHCU decarboxylase; Provisional; Region: PRK13798 1133849001087 enoyl-CoA hydratase; Provisional; Region: PRK06142 1133849001088 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1133849001089 substrate binding site [chemical binding]; other site 1133849001090 oxyanion hole (OAH) forming residues; other site 1133849001091 trimer interface [polypeptide binding]; other site 1133849001092 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1133849001093 MarR family; Region: MarR_2; pfam12802 1133849001094 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1133849001095 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849001096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849001097 Putative sensor; Region: Sensor; pfam13796 1133849001098 Histidine kinase; Region: HisKA_3; pfam07730 1133849001099 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1133849001100 ATP binding site [chemical binding]; other site 1133849001101 Mg2+ binding site [ion binding]; other site 1133849001102 G-X-G motif; other site 1133849001103 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849001104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849001105 active site 1133849001106 phosphorylation site [posttranslational modification] 1133849001107 intermolecular recognition site; other site 1133849001108 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849001109 DNA binding residues [nucleotide binding] 1133849001110 dimerization interface [polypeptide binding]; other site 1133849001111 TAP-like protein; Region: Abhydrolase_4; pfam08386 1133849001112 Beta-lactamase; Region: Beta-lactamase; pfam00144 1133849001113 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1133849001114 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1133849001115 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1133849001116 AAA ATPase domain; Region: AAA_16; pfam13191 1133849001117 NB-ARC domain; Region: NB-ARC; pfam00931 1133849001118 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849001119 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1133849001120 binding surface 1133849001121 TPR motif; other site 1133849001122 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849001123 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1133849001124 dimer interface [polypeptide binding]; other site 1133849001125 substrate binding site [chemical binding]; other site 1133849001126 metal binding sites [ion binding]; metal-binding site 1133849001127 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1133849001128 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1133849001129 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1133849001130 putative hydrolase; Region: TIGR03624 1133849001131 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1133849001132 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1133849001133 Ligand Binding Site [chemical binding]; other site 1133849001134 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1133849001135 active site 1133849001136 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1133849001137 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1133849001138 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1133849001139 substrate binding site [chemical binding]; other site 1133849001140 activation loop (A-loop); other site 1133849001141 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1133849001142 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1133849001143 active site 1133849001144 ATP binding site [chemical binding]; other site 1133849001145 substrate binding site [chemical binding]; other site 1133849001146 activation loop (A-loop); other site 1133849001147 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1133849001148 Amidase; Region: Amidase; cl11426 1133849001149 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1133849001150 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1133849001151 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1133849001152 dimerization interface [polypeptide binding]; other site 1133849001153 substrate binding pocket [chemical binding]; other site 1133849001154 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1133849001155 short chain dehydrogenase; Provisional; Region: PRK07825 1133849001156 classical (c) SDRs; Region: SDR_c; cd05233 1133849001157 NAD(P) binding site [chemical binding]; other site 1133849001158 active site 1133849001159 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1133849001160 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 1133849001161 NAD(P) binding site [chemical binding]; other site 1133849001162 catalytic residues [active] 1133849001163 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1133849001164 Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349 1133849001165 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 1133849001166 FtsH Extracellular; Region: FtsH_ext; pfam06480 1133849001167 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1133849001168 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1133849001169 Walker A motif; other site 1133849001170 ATP binding site [chemical binding]; other site 1133849001171 Walker B motif; other site 1133849001172 arginine finger; other site 1133849001173 Peptidase family M41; Region: Peptidase_M41; pfam01434 1133849001174 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1133849001175 homodecamer interface [polypeptide binding]; other site 1133849001176 GTP cyclohydrolase I; Provisional; Region: PLN03044 1133849001177 active site 1133849001178 putative catalytic site residues [active] 1133849001179 zinc binding site [ion binding]; other site 1133849001180 GTP-CH-I/GFRP interaction surface; other site 1133849001181 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1133849001182 dihydropteroate synthase; Region: DHPS; TIGR01496 1133849001183 substrate binding pocket [chemical binding]; other site 1133849001184 dimer interface [polypeptide binding]; other site 1133849001185 inhibitor binding site; inhibition site 1133849001186 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1133849001187 homooctamer interface [polypeptide binding]; other site 1133849001188 active site 1133849001189 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1133849001190 catalytic center binding site [active] 1133849001191 ATP binding site [chemical binding]; other site 1133849001192 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1133849001193 Rossmann-like domain; Region: Rossmann-like; pfam10727 1133849001194 Uncharacterized conserved protein [Function unknown]; Region: COG5495 1133849001195 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1133849001196 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1133849001197 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1133849001198 active site 1133849001199 ATP-binding site [chemical binding]; other site 1133849001200 pantoate-binding site; other site 1133849001201 HXXH motif; other site 1133849001202 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1133849001203 tetramerization interface [polypeptide binding]; other site 1133849001204 active site 1133849001205 pantothenate kinase; Reviewed; Region: PRK13318 1133849001206 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1133849001207 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1133849001208 active site residue [active] 1133849001209 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1133849001210 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1133849001211 dimer interface [polypeptide binding]; other site 1133849001212 putative anticodon binding site; other site 1133849001213 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1133849001214 motif 1; other site 1133849001215 dimer interface [polypeptide binding]; other site 1133849001216 active site 1133849001217 motif 2; other site 1133849001218 motif 3; other site 1133849001219 Lsr2; Region: Lsr2; pfam11774 1133849001220 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1133849001221 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1133849001222 phosphopeptide binding site; other site 1133849001223 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849001224 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849001225 DNA binding residues [nucleotide binding] 1133849001226 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 1133849001227 Lipase (class 2); Region: Lipase_2; pfam01674 1133849001228 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1133849001229 hypothetical protein; Provisional; Region: PRK06753 1133849001230 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1133849001231 Condensation domain; Region: Condensation; pfam00668 1133849001232 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849001233 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1133849001234 acyl-activating enzyme (AAE) consensus motif; other site 1133849001235 AMP binding site [chemical binding]; other site 1133849001236 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849001237 Condensation domain; Region: Condensation; pfam00668 1133849001238 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849001239 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849001240 acyl-activating enzyme (AAE) consensus motif; other site 1133849001241 AMP binding site [chemical binding]; other site 1133849001242 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849001243 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1133849001244 short chain dehydrogenase; Validated; Region: PRK06182 1133849001245 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1133849001246 NADP binding site [chemical binding]; other site 1133849001247 active site 1133849001248 steroid binding site; other site 1133849001249 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1133849001250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849001251 putative substrate translocation pore; other site 1133849001252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849001253 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1133849001254 Clp amino terminal domain; Region: Clp_N; pfam02861 1133849001255 Clp amino terminal domain; Region: Clp_N; pfam02861 1133849001256 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1133849001257 Walker A motif; other site 1133849001258 ATP binding site [chemical binding]; other site 1133849001259 Walker B motif; other site 1133849001260 arginine finger; other site 1133849001261 UvrB/uvrC motif; Region: UVR; pfam02151 1133849001262 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1133849001263 Walker A motif; other site 1133849001264 ATP binding site [chemical binding]; other site 1133849001265 Walker B motif; other site 1133849001266 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1133849001267 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 1133849001268 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1133849001269 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1133849001270 metal ion-dependent adhesion site (MIDAS); other site 1133849001271 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849001272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849001273 active site 1133849001274 phosphorylation site [posttranslational modification] 1133849001275 intermolecular recognition site; other site 1133849001276 dimerization interface [polypeptide binding]; other site 1133849001277 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849001278 DNA binding residues [nucleotide binding] 1133849001279 dimerization interface [polypeptide binding]; other site 1133849001280 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1133849001281 Histidine kinase; Region: HisKA_3; pfam07730 1133849001282 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1133849001283 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1133849001284 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1133849001285 Walker A/P-loop; other site 1133849001286 ATP binding site [chemical binding]; other site 1133849001287 Q-loop/lid; other site 1133849001288 ABC transporter signature motif; other site 1133849001289 Walker B; other site 1133849001290 D-loop; other site 1133849001291 H-loop/switch region; other site 1133849001292 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849001293 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1133849001294 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1133849001295 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1133849001296 OsmC-like protein; Region: OsmC; cl00767 1133849001297 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 1133849001298 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1133849001299 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849001300 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1133849001301 catalytic site [active] 1133849001302 TAP-like protein; Region: Abhydrolase_4; pfam08386 1133849001303 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1133849001304 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1133849001305 minor groove reading motif; other site 1133849001306 helix-hairpin-helix signature motif; other site 1133849001307 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1133849001308 active site clefts [active] 1133849001309 zinc binding site [ion binding]; other site 1133849001310 dimer interface [polypeptide binding]; other site 1133849001311 DNA repair protein RadA; Provisional; Region: PRK11823 1133849001312 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1133849001313 Walker A motif; other site 1133849001314 ATP binding site [chemical binding]; other site 1133849001315 Walker B motif; other site 1133849001316 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1133849001317 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1133849001318 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1133849001319 substrate binding site; other site 1133849001320 dimer interface; other site 1133849001321 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1133849001322 homotrimer interaction site [polypeptide binding]; other site 1133849001323 zinc binding site [ion binding]; other site 1133849001324 CDP-binding sites; other site 1133849001325 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1133849001326 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1133849001327 active site 1133849001328 HIGH motif; other site 1133849001329 nucleotide binding site [chemical binding]; other site 1133849001330 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1133849001331 KMSKS motif; other site 1133849001332 This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840 1133849001333 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1133849001334 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1133849001335 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1133849001336 enoyl-CoA hydratase; Provisional; Region: PRK08260 1133849001337 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1133849001338 substrate binding site [chemical binding]; other site 1133849001339 oxyanion hole (OAH) forming residues; other site 1133849001340 trimer interface [polypeptide binding]; other site 1133849001341 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849001342 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1133849001343 active site 1133849001344 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1133849001345 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1133849001346 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849001347 Walker A/P-loop; other site 1133849001348 ATP binding site [chemical binding]; other site 1133849001349 Q-loop/lid; other site 1133849001350 ABC transporter signature motif; other site 1133849001351 Walker B; other site 1133849001352 D-loop; other site 1133849001353 H-loop/switch region; other site 1133849001354 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1133849001355 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1133849001356 intersubunit interface [polypeptide binding]; other site 1133849001357 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1133849001358 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 1133849001359 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1133849001360 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1133849001361 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849001362 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849001363 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849001364 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849001365 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849001366 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849001367 active site 1133849001368 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849001369 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1133849001370 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849001371 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849001372 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849001373 active site 1133849001374 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1133849001375 active site 1133849001376 catalytic site [active] 1133849001377 DUF35 OB-fold domain; Region: DUF35; pfam01796 1133849001378 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1133849001379 putative active site [active] 1133849001380 putative catalytic site [active] 1133849001381 lipid-transfer protein; Provisional; Region: PRK07855 1133849001382 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1133849001383 active site 1133849001384 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1133849001385 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 1133849001386 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849001387 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849001388 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1133849001389 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683 1133849001390 nudix motif; other site 1133849001391 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1133849001392 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1133849001393 oligomeric interface; other site 1133849001394 putative active site [active] 1133849001395 homodimer interface [polypeptide binding]; other site 1133849001396 Predicted ATPase [General function prediction only]; Region: COG1485 1133849001397 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1133849001398 MoxR-like ATPases [General function prediction only]; Region: COG0714 1133849001399 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1133849001400 Walker A motif; other site 1133849001401 ATP binding site [chemical binding]; other site 1133849001402 Walker B motif; other site 1133849001403 arginine finger; other site 1133849001404 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1133849001405 Protein of unknown function DUF58; Region: DUF58; pfam01882 1133849001406 enoyl-CoA hydratase; Region: PLN02864 1133849001407 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 1133849001408 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1133849001409 dimer interaction site [polypeptide binding]; other site 1133849001410 substrate-binding tunnel; other site 1133849001411 active site 1133849001412 catalytic site [active] 1133849001413 substrate binding site [chemical binding]; other site 1133849001414 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 1133849001415 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1133849001416 hypothetical protein; Validated; Region: PRK07121 1133849001417 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1133849001418 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 1133849001419 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1133849001420 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1133849001421 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1133849001422 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1133849001423 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1133849001424 active site 1133849001425 catalytic residues [active] 1133849001426 metal binding site [ion binding]; metal-binding site 1133849001427 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1133849001428 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1133849001429 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1133849001430 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1133849001431 putative active site [active] 1133849001432 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1133849001433 MarR family; Region: MarR; pfam01047 1133849001434 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1133849001435 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1133849001436 NADP binding site [chemical binding]; other site 1133849001437 homodimer interface [polypeptide binding]; other site 1133849001438 active site 1133849001439 substrate binding site [chemical binding]; other site 1133849001440 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1133849001441 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1133849001442 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1133849001443 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1133849001444 active site 1133849001445 Fe binding site [ion binding]; other site 1133849001446 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1133849001447 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1133849001448 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1133849001449 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849001450 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 1133849001451 Flavin binding site [chemical binding]; other site 1133849001452 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1133849001453 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 1133849001454 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1133849001455 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1133849001456 FMN binding site [chemical binding]; other site 1133849001457 substrate binding site [chemical binding]; other site 1133849001458 putative catalytic residue [active] 1133849001459 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 1133849001460 Cupin; Region: Cupin_6; pfam12852 1133849001461 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849001462 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1133849001463 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849001464 Phosphotransferase enzyme family; Region: APH; pfam01636 1133849001465 active site 1133849001466 ATP binding site [chemical binding]; other site 1133849001467 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1133849001468 substrate binding site [chemical binding]; other site 1133849001469 Domain of unknown function (DUF427); Region: DUF427; pfam04248 1133849001470 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1133849001471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849001472 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1133849001473 putative substrate translocation pore; other site 1133849001474 MarR family; Region: MarR; pfam01047 1133849001475 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1133849001476 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 1133849001477 active site 1133849001478 conformational flexibility of ligand binding pocket; other site 1133849001479 ADP-ribosylating toxin turn-turn motif; other site 1133849001480 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1133849001481 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1133849001482 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849001483 active site 1133849001484 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1133849001485 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1133849001486 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849001487 active site 1133849001488 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849001489 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849001490 active site 1133849001491 enoyl-CoA hydratase; Provisional; Region: PRK08290 1133849001492 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1133849001493 substrate binding site [chemical binding]; other site 1133849001494 oxyanion hole (OAH) forming residues; other site 1133849001495 trimer interface [polypeptide binding]; other site 1133849001496 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1133849001497 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849001498 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1133849001499 acyl-activating enzyme (AAE) consensus motif; other site 1133849001500 acyl-activating enzyme (AAE) consensus motif; other site 1133849001501 putative AMP binding site [chemical binding]; other site 1133849001502 putative active site [active] 1133849001503 putative CoA binding site [chemical binding]; other site 1133849001504 CoA binding site [chemical binding]; other site 1133849001505 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849001506 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1133849001507 active site 1133849001508 short chain dehydrogenase; Provisional; Region: PRK07831 1133849001509 classical (c) SDRs; Region: SDR_c; cd05233 1133849001510 NAD(P) binding site [chemical binding]; other site 1133849001511 active site 1133849001512 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849001513 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849001514 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1133849001515 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1133849001516 dimer interface [polypeptide binding]; other site 1133849001517 active site 1133849001518 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1133849001519 Nitronate monooxygenase; Region: NMO; pfam03060 1133849001520 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1133849001521 FMN binding site [chemical binding]; other site 1133849001522 substrate binding site [chemical binding]; other site 1133849001523 putative catalytic residue [active] 1133849001524 Coenzyme A transferase; Region: CoA_trans; cl17247 1133849001525 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1133849001526 enoyl-CoA hydratase; Provisional; Region: PRK06495 1133849001527 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1133849001528 substrate binding site [chemical binding]; other site 1133849001529 oxyanion hole (OAH) forming residues; other site 1133849001530 trimer interface [polypeptide binding]; other site 1133849001531 short chain dehydrogenase; Provisional; Region: PRK07856 1133849001532 classical (c) SDRs; Region: SDR_c; cd05233 1133849001533 NAD(P) binding site [chemical binding]; other site 1133849001534 active site 1133849001535 short chain dehydrogenase; Provisional; Region: PRK07791 1133849001536 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849001537 NAD(P) binding site [chemical binding]; other site 1133849001538 active site 1133849001539 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1133849001540 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1133849001541 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849001542 sequence-specific DNA binding site [nucleotide binding]; other site 1133849001543 salt bridge; other site 1133849001544 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 1133849001545 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1133849001546 dimer interface [polypeptide binding]; other site 1133849001547 active site 1133849001548 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849001549 Cytochrome P450; Region: p450; cl12078 1133849001550 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1133849001551 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1133849001552 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1133849001553 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 1133849001554 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1133849001555 active site 1133849001556 lipid-transfer protein; Provisional; Region: PRK07937 1133849001557 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1133849001558 active site 1133849001559 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1133849001560 DUF35 OB-fold domain; Region: DUF35; pfam01796 1133849001561 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1133849001562 DUF35 OB-fold domain; Region: DUF35; pfam01796 1133849001563 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1133849001564 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1133849001565 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1133849001566 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849001567 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1133849001568 acyl-activating enzyme (AAE) consensus motif; other site 1133849001569 acyl-activating enzyme (AAE) consensus motif; other site 1133849001570 putative AMP binding site [chemical binding]; other site 1133849001571 putative active site [active] 1133849001572 putative CoA binding site [chemical binding]; other site 1133849001573 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1133849001574 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1133849001575 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849001576 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1133849001577 DNA binding residues [nucleotide binding] 1133849001578 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1133849001579 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1133849001580 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849001581 enoyl-CoA hydratase; Provisional; Region: PRK07799 1133849001582 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1133849001583 substrate binding site [chemical binding]; other site 1133849001584 oxyanion hole (OAH) forming residues; other site 1133849001585 trimer interface [polypeptide binding]; other site 1133849001586 acyl-CoA synthetase; Validated; Region: PRK07798 1133849001587 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849001588 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 1133849001589 acyl-activating enzyme (AAE) consensus motif; other site 1133849001590 acyl-activating enzyme (AAE) consensus motif; other site 1133849001591 putative AMP binding site [chemical binding]; other site 1133849001592 putative active site [active] 1133849001593 putative CoA binding site [chemical binding]; other site 1133849001594 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849001595 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1133849001596 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1133849001597 active site 1133849001598 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849001599 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1133849001600 FAD binding site [chemical binding]; other site 1133849001601 substrate binding site [chemical binding]; other site 1133849001602 catalytic base [active] 1133849001603 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1133849001604 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1133849001605 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849001606 NAD(P) binding site [chemical binding]; other site 1133849001607 active site 1133849001608 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1133849001609 Permease; Region: Permease; pfam02405 1133849001610 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1133849001611 Permease; Region: Permease; pfam02405 1133849001612 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1133849001613 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1133849001614 mce related protein; Region: MCE; pfam02470 1133849001615 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1133849001616 mce related protein; Region: MCE; pfam02470 1133849001617 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1133849001618 mce related protein; Region: MCE; pfam02470 1133849001619 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1133849001620 mce related protein; Region: MCE; pfam02470 1133849001621 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1133849001622 mce related protein; Region: MCE; pfam02470 1133849001623 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1133849001624 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1133849001625 dimerization interface [polypeptide binding]; other site 1133849001626 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1133849001627 dimer interface [polypeptide binding]; other site 1133849001628 phosphorylation site [posttranslational modification] 1133849001629 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849001630 ATP binding site [chemical binding]; other site 1133849001631 G-X-G motif; other site 1133849001632 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1133849001633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849001634 active site 1133849001635 phosphorylation site [posttranslational modification] 1133849001636 intermolecular recognition site; other site 1133849001637 dimerization interface [polypeptide binding]; other site 1133849001638 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1133849001639 DNA binding site [nucleotide binding] 1133849001640 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1133849001641 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1133849001642 active site 1133849001643 homotetramer interface [polypeptide binding]; other site 1133849001644 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849001645 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1133849001646 MbtH-like protein; Region: MbtH; pfam03621 1133849001647 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1133849001648 nucleotide binding site/active site [active] 1133849001649 HIT family signature motif; other site 1133849001650 catalytic residue [active] 1133849001651 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1133849001652 pentamer interface [polypeptide binding]; other site 1133849001653 dodecaamer interface [polypeptide binding]; other site 1133849001654 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1133849001655 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1133849001656 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1133849001657 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1133849001658 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1133849001659 Peptidase family M23; Region: Peptidase_M23; pfam01551 1133849001660 aspartate aminotransferase; Provisional; Region: PRK05764 1133849001661 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1133849001662 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849001663 homodimer interface [polypeptide binding]; other site 1133849001664 catalytic residue [active] 1133849001665 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1133849001666 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1133849001667 tetramer interface [polypeptide binding]; other site 1133849001668 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1133849001669 nucleotide binding site/active site [active] 1133849001670 HIT family signature motif; other site 1133849001671 catalytic residue [active] 1133849001672 Predicted esterase [General function prediction only]; Region: COG0627 1133849001673 S-formylglutathione hydrolase; Region: PLN02442 1133849001674 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849001675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849001676 active site 1133849001677 phosphorylation site [posttranslational modification] 1133849001678 intermolecular recognition site; other site 1133849001679 dimerization interface [polypeptide binding]; other site 1133849001680 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849001681 DNA binding residues [nucleotide binding] 1133849001682 dimerization interface [polypeptide binding]; other site 1133849001683 Histidine kinase; Region: HisKA_3; pfam07730 1133849001684 YcaO-like family; Region: YcaO; pfam02624 1133849001685 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1133849001686 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827 1133849001687 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1133849001688 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1133849001689 FMN binding site [chemical binding]; other site 1133849001690 active site 1133849001691 substrate binding site [chemical binding]; other site 1133849001692 catalytic residue [active] 1133849001693 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 1133849001694 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1133849001695 DNA binding residues [nucleotide binding] 1133849001696 putative dimer interface [polypeptide binding]; other site 1133849001697 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1133849001698 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1133849001699 Predicted deacetylase [General function prediction only]; Region: COG3233 1133849001700 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 1133849001701 putative active site [active] 1133849001702 putative Zn binding site [ion binding]; other site 1133849001703 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1133849001704 L-tyrosine decarboxylase; Provisional; Region: PRK13520 1133849001705 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849001706 catalytic residue [active] 1133849001707 hypothetical protein; Provisional; Region: PRK07907 1133849001708 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1133849001709 active site 1133849001710 metal binding site [ion binding]; metal-binding site 1133849001711 dimer interface [polypeptide binding]; other site 1133849001712 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1133849001713 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1133849001714 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1133849001715 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1133849001716 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1133849001717 putative active site [active] 1133849001718 catalytic triad [active] 1133849001719 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1133849001720 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 1133849001721 putative ligand binding site [chemical binding]; other site 1133849001722 MarR family; Region: MarR; pfam01047 1133849001723 Putative esterase; Region: Esterase; pfam00756 1133849001724 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1133849001725 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1133849001726 active site 1133849001727 metal binding site [ion binding]; metal-binding site 1133849001728 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1133849001729 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1133849001730 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1133849001731 dimerization interface [polypeptide binding]; other site 1133849001732 ATP binding site [chemical binding]; other site 1133849001733 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1133849001734 dimerization interface [polypeptide binding]; other site 1133849001735 ATP binding site [chemical binding]; other site 1133849001736 Predicted membrane protein [Function unknown]; Region: COG4425 1133849001737 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1133849001738 yiaA/B two helix domain; Region: YiaAB; cl01759 1133849001739 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1133849001740 CAAX protease self-immunity; Region: Abi; pfam02517 1133849001741 Beta-lactamase; Region: Beta-lactamase; pfam00144 1133849001742 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1133849001743 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849001744 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849001745 active site 1133849001746 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1133849001747 Protein of unknown function (DUF3533); Region: DUF3533; pfam12051 1133849001748 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1133849001749 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1133849001750 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1133849001751 active site 1133849001752 tetramer interface [polypeptide binding]; other site 1133849001753 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1133849001754 active site 1133849001755 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1133849001756 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1133849001757 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1133849001758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849001759 putative PBP binding loops; other site 1133849001760 dimer interface [polypeptide binding]; other site 1133849001761 ABC-ATPase subunit interface; other site 1133849001762 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1133849001763 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849001764 dimer interface [polypeptide binding]; other site 1133849001765 conserved gate region; other site 1133849001766 ABC-ATPase subunit interface; other site 1133849001767 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1133849001768 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1133849001769 Walker A/P-loop; other site 1133849001770 ATP binding site [chemical binding]; other site 1133849001771 Q-loop/lid; other site 1133849001772 ABC transporter signature motif; other site 1133849001773 Walker B; other site 1133849001774 D-loop; other site 1133849001775 H-loop/switch region; other site 1133849001776 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1133849001777 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1133849001778 Walker A/P-loop; other site 1133849001779 ATP binding site [chemical binding]; other site 1133849001780 Q-loop/lid; other site 1133849001781 ABC transporter signature motif; other site 1133849001782 Walker B; other site 1133849001783 D-loop; other site 1133849001784 H-loop/switch region; other site 1133849001785 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1133849001786 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1133849001787 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1133849001788 dimerization interface [polypeptide binding]; other site 1133849001789 putative ATP binding site [chemical binding]; other site 1133849001790 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1133849001791 L-asparaginase II; Region: Asparaginase_II; pfam06089 1133849001792 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1133849001793 MOSC domain; Region: MOSC; pfam03473 1133849001794 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1133849001795 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1133849001796 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1133849001797 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1133849001798 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1133849001799 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849001800 catalytic residue [active] 1133849001801 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1133849001802 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1133849001803 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1133849001804 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 1133849001805 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1133849001806 Walker A/P-loop; other site 1133849001807 ATP binding site [chemical binding]; other site 1133849001808 Q-loop/lid; other site 1133849001809 ABC transporter signature motif; other site 1133849001810 Walker B; other site 1133849001811 D-loop; other site 1133849001812 H-loop/switch region; other site 1133849001813 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1133849001814 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849001815 ABC transporter signature motif; other site 1133849001816 Walker B; other site 1133849001817 D-loop; other site 1133849001818 H-loop/switch region; other site 1133849001819 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1133849001820 heme-binding site [chemical binding]; other site 1133849001821 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 1133849001822 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1133849001823 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1133849001824 active site residue [active] 1133849001825 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1133849001826 active site residue [active] 1133849001827 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 1133849001828 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1133849001829 catalytic residues [active] 1133849001830 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1133849001831 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1133849001832 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1133849001833 DNA binding site [nucleotide binding] 1133849001834 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1133849001835 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1133849001836 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1133849001837 PBP superfamily domain; Region: PBP_like_2; cl17296 1133849001838 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1133849001839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849001840 dimer interface [polypeptide binding]; other site 1133849001841 conserved gate region; other site 1133849001842 putative PBP binding loops; other site 1133849001843 ABC-ATPase subunit interface; other site 1133849001844 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1133849001845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849001846 dimer interface [polypeptide binding]; other site 1133849001847 conserved gate region; other site 1133849001848 putative PBP binding loops; other site 1133849001849 ABC-ATPase subunit interface; other site 1133849001850 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1133849001851 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1133849001852 Walker A/P-loop; other site 1133849001853 ATP binding site [chemical binding]; other site 1133849001854 Q-loop/lid; other site 1133849001855 ABC transporter signature motif; other site 1133849001856 Walker B; other site 1133849001857 D-loop; other site 1133849001858 H-loop/switch region; other site 1133849001859 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1133849001860 PhoU domain; Region: PhoU; pfam01895 1133849001861 PhoU domain; Region: PhoU; pfam01895 1133849001862 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1133849001863 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1133849001864 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1133849001865 FMN binding site [chemical binding]; other site 1133849001866 active site 1133849001867 catalytic residues [active] 1133849001868 substrate binding site [chemical binding]; other site 1133849001869 short chain dehydrogenase; Provisional; Region: PRK07791 1133849001870 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849001871 NAD(P) binding site [chemical binding]; other site 1133849001872 active site 1133849001873 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1133849001874 hydrophobic ligand binding site; other site 1133849001875 lipid-transfer protein; Provisional; Region: PRK08256 1133849001876 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1133849001877 active site 1133849001878 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1133849001879 active site 1133849001880 catalytic site [active] 1133849001881 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1133849001882 active site 2 [active] 1133849001883 active site 1 [active] 1133849001884 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1133849001885 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1133849001886 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849001887 short chain dehydrogenase; Provisional; Region: PRK07825 1133849001888 classical (c) SDRs; Region: SDR_c; cd05233 1133849001889 NAD(P) binding site [chemical binding]; other site 1133849001890 active site 1133849001891 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 1133849001892 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 1133849001893 homodimer interface [polypeptide binding]; other site 1133849001894 putative substrate binding pocket [chemical binding]; other site 1133849001895 diiron center [ion binding]; other site 1133849001896 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 1133849001897 The ML (MD-2-related lipid-recognition) domain is present in MD-1, MD-2, GM2 activator protein, Niemann-Pick type C2 (Npc2) protein, phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP), mite allergen Der p 2 and several proteins of...; Region: ML; cl00274 1133849001898 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849001899 dimerization interface [polypeptide binding]; other site 1133849001900 putative DNA binding site [nucleotide binding]; other site 1133849001901 putative Zn2+ binding site [ion binding]; other site 1133849001902 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1133849001903 hydrophobic ligand binding site; other site 1133849001904 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1133849001905 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1133849001906 Ligand binding site; other site 1133849001907 DXD motif; other site 1133849001908 Putative Catalytic site; other site 1133849001909 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1133849001910 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1133849001911 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1133849001912 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1133849001913 putative acyl-acceptor binding pocket; other site 1133849001914 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 1133849001915 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1133849001916 putative acyl-acceptor binding pocket; other site 1133849001917 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 1133849001918 salicylate synthase MbtI; Reviewed; Region: PRK07912 1133849001919 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1133849001920 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1133849001921 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1133849001922 acyl-activating enzyme (AAE) consensus motif; other site 1133849001923 active site 1133849001924 AMP binding site [chemical binding]; other site 1133849001925 substrate binding site [chemical binding]; other site 1133849001926 short chain dehydrogenase; Provisional; Region: PRK06197 1133849001927 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1133849001928 putative NAD(P) binding site [chemical binding]; other site 1133849001929 active site 1133849001930 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1133849001931 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 1133849001932 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1133849001933 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1133849001934 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1133849001935 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1133849001936 Predicted membrane protein [Function unknown]; Region: COG2860 1133849001937 UPF0126 domain; Region: UPF0126; pfam03458 1133849001938 UPF0126 domain; Region: UPF0126; pfam03458 1133849001939 RibD C-terminal domain; Region: RibD_C; cl17279 1133849001940 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1133849001941 aminotransferase; Validated; Region: PRK07777 1133849001942 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1133849001943 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849001944 homodimer interface [polypeptide binding]; other site 1133849001945 catalytic residue [active] 1133849001946 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1133849001947 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849001948 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1133849001949 DNA binding residues [nucleotide binding] 1133849001950 SnoaL-like domain; Region: SnoaL_2; pfam12680 1133849001951 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1133849001952 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1133849001953 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1133849001954 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1133849001955 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1133849001956 putative Mg++ binding site [ion binding]; other site 1133849001957 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1133849001958 nucleotide binding region [chemical binding]; other site 1133849001959 ATP-binding site [chemical binding]; other site 1133849001960 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 1133849001961 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1133849001962 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1133849001963 Zn binding site [ion binding]; other site 1133849001964 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1133849001965 WYL domain; Region: WYL; cl14852 1133849001966 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1133849001967 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1133849001968 DNA-binding site [nucleotide binding]; DNA binding site 1133849001969 RNA-binding motif; other site 1133849001970 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 1133849001971 Glutamine cyclotransferase; Region: Glu_cyclase_2; pfam05096 1133849001972 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1133849001973 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849001974 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849001975 CENP-B N-terminal DNA-binding domain; Region: CENP-B_N; pfam04218 1133849001976 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 1133849001977 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 1133849001978 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1133849001979 MarR family; Region: MarR_2; cl17246 1133849001980 hypothetical protein; Provisional; Region: PRK11770 1133849001981 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1133849001982 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1133849001983 hypothetical protein; Provisional; Region: PRK01346 1133849001984 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1133849001985 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1133849001986 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1133849001987 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 1133849001988 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1133849001989 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1133849001990 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849001991 catalytic residue [active] 1133849001992 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1133849001993 Putative catalytic NodB homology domain of uncharacterized BH0857 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH0857_like; cd10955 1133849001994 NodB motif; other site 1133849001995 putative active site [active] 1133849001996 putative catalytic site [active] 1133849001997 citrate synthase 2; Provisional; Region: PRK12350 1133849001998 Citrate synthase; Region: Citrate_synt; pfam00285 1133849001999 oxalacetate binding site [chemical binding]; other site 1133849002000 citrylCoA binding site [chemical binding]; other site 1133849002001 coenzyme A binding site [chemical binding]; other site 1133849002002 catalytic triad [active] 1133849002003 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1133849002004 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1133849002005 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1133849002006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849002007 H+ Antiporter protein; Region: 2A0121; TIGR00900 1133849002008 putative substrate translocation pore; other site 1133849002009 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1133849002010 dimer interface [polypeptide binding]; other site 1133849002011 Citrate synthase; Region: Citrate_synt; pfam00285 1133849002012 active site 1133849002013 citrylCoA binding site [chemical binding]; other site 1133849002014 NADH binding [chemical binding]; other site 1133849002015 cationic pore residues; other site 1133849002016 oxalacetate/citrate binding site [chemical binding]; other site 1133849002017 coenzyme A binding site [chemical binding]; other site 1133849002018 catalytic triad [active] 1133849002019 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1133849002020 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1133849002021 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1133849002022 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1133849002023 phosphorylation site [posttranslational modification] 1133849002024 dimer interface [polypeptide binding]; other site 1133849002025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849002026 Mg2+ binding site [ion binding]; other site 1133849002027 G-X-G motif; other site 1133849002028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849002029 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1133849002030 active site 1133849002031 phosphorylation site [posttranslational modification] 1133849002032 intermolecular recognition site; other site 1133849002033 dimerization interface [polypeptide binding]; other site 1133849002034 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1133849002035 DNA binding site [nucleotide binding] 1133849002036 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 1133849002037 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849002038 acyl-activating enzyme (AAE) consensus motif; other site 1133849002039 AMP binding site [chemical binding]; other site 1133849002040 active site 1133849002041 CoA binding site [chemical binding]; other site 1133849002042 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1133849002043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849002044 ATP binding site [chemical binding]; other site 1133849002045 Mg2+ binding site [ion binding]; other site 1133849002046 G-X-G motif; other site 1133849002047 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 1133849002048 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1133849002049 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1133849002050 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1133849002051 G1 box; other site 1133849002052 GTP/Mg2+ binding site [chemical binding]; other site 1133849002053 G2 box; other site 1133849002054 Switch I region; other site 1133849002055 G3 box; other site 1133849002056 Switch II region; other site 1133849002057 G4 box; other site 1133849002058 G5 box; other site 1133849002059 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 1133849002060 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1133849002061 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1133849002062 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1133849002063 oligomeric interface; other site 1133849002064 putative active site [active] 1133849002065 homodimer interface [polypeptide binding]; other site 1133849002066 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1133849002067 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1133849002068 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1133849002069 active site 1133849002070 catalytic tetrad [active] 1133849002071 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1133849002072 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1133849002073 enoyl-CoA hydratase; Provisional; Region: PRK06688 1133849002074 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1133849002075 substrate binding site [chemical binding]; other site 1133849002076 oxyanion hole (OAH) forming residues; other site 1133849002077 trimer interface [polypeptide binding]; other site 1133849002078 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1133849002079 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1133849002080 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1133849002081 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 1133849002082 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 1133849002083 nucleotide binding site [chemical binding]; other site 1133849002084 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 1133849002085 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1133849002086 active site 1133849002087 DNA binding site [nucleotide binding] 1133849002088 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1133849002089 DNA binding site [nucleotide binding] 1133849002090 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1133849002091 Secretory lipase; Region: LIP; pfam03583 1133849002092 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1133849002093 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1133849002094 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1133849002095 Walker A/P-loop; other site 1133849002096 ATP binding site [chemical binding]; other site 1133849002097 Q-loop/lid; other site 1133849002098 ABC transporter signature motif; other site 1133849002099 Walker B; other site 1133849002100 D-loop; other site 1133849002101 H-loop/switch region; other site 1133849002102 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1133849002103 Walker A/P-loop; other site 1133849002104 ATP binding site [chemical binding]; other site 1133849002105 Q-loop/lid; other site 1133849002106 ABC transporter signature motif; other site 1133849002107 Walker B; other site 1133849002108 D-loop; other site 1133849002109 H-loop/switch region; other site 1133849002110 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1133849002111 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1133849002112 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1133849002113 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1133849002114 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849002115 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1133849002116 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1133849002117 active site 1133849002118 metal binding site [ion binding]; metal-binding site 1133849002119 hexamer interface [polypeptide binding]; other site 1133849002120 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1133849002121 MarR family; Region: MarR; pfam01047 1133849002122 TIGR03086 family protein; Region: TIGR03086 1133849002123 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1133849002124 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1133849002125 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1133849002126 active site 1133849002127 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1133849002128 cyclase homology domain; Region: CHD; cd07302 1133849002129 nucleotidyl binding site; other site 1133849002130 metal binding site [ion binding]; metal-binding site 1133849002131 dimer interface [polypeptide binding]; other site 1133849002132 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1133849002133 DNA binding site [nucleotide binding] 1133849002134 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1133849002135 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849002136 Predicted transcriptional regulators [Transcription]; Region: COG1695 1133849002137 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1133849002138 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1133849002139 putative hydrophobic ligand binding site [chemical binding]; other site 1133849002140 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1133849002141 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849002142 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1133849002143 YCII-related domain; Region: YCII; cl00999 1133849002144 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849002145 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849002146 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849002147 active site 1133849002148 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1133849002149 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1133849002150 dimer interface [polypeptide binding]; other site 1133849002151 active site 1133849002152 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1133849002153 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1133849002154 substrate binding site [chemical binding]; other site 1133849002155 oxyanion hole (OAH) forming residues; other site 1133849002156 trimer interface [polypeptide binding]; other site 1133849002157 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1133849002158 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1133849002159 HNH endonuclease; Region: HNH_2; pfam13391 1133849002160 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1133849002161 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849002162 catalytic residue [active] 1133849002163 DNA-sulfur modification-associated; Region: DndB; cl17621 1133849002164 DGQHR domain; Region: DGQHR; TIGR03187 1133849002165 hypothetical protein; Provisional; Region: PRK06850 1133849002166 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 1133849002167 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849002168 ABC transporter signature motif; other site 1133849002169 Walker B; other site 1133849002170 D-loop; other site 1133849002171 H-loop/switch region; other site 1133849002172 Domain of unknown function (DUF1832); Region: DUF1832; cl07463 1133849002173 Integrase core domain; Region: rve_3; cl15866 1133849002174 Integrase core domain; Region: rve; pfam00665 1133849002175 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1133849002176 Transposase; Region: HTH_Tnp_1; pfam01527 1133849002177 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849002178 Walker B; other site 1133849002179 D-loop; other site 1133849002180 H-loop/switch region; other site 1133849002181 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1133849002182 nucleotide binding region [chemical binding]; other site 1133849002183 ATP-binding site [chemical binding]; other site 1133849002184 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1133849002185 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849002186 S-adenosylmethionine binding site [chemical binding]; other site 1133849002187 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 1133849002188 active site triad [active] 1133849002189 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1133849002190 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1133849002191 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849002192 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849002193 active site 1133849002194 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1133849002195 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849002196 dimerization interface [polypeptide binding]; other site 1133849002197 putative DNA binding site [nucleotide binding]; other site 1133849002198 putative Zn2+ binding site [ion binding]; other site 1133849002199 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1133849002200 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1133849002201 Beta-lactamase; Region: Beta-lactamase; pfam00144 1133849002202 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1133849002203 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1133849002204 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1133849002205 dimer interface [polypeptide binding]; other site 1133849002206 acyl-activating enzyme (AAE) consensus motif; other site 1133849002207 putative active site [active] 1133849002208 AMP binding site [chemical binding]; other site 1133849002209 putative CoA binding site [chemical binding]; other site 1133849002210 Nitronate monooxygenase; Region: NMO; pfam03060 1133849002211 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1133849002212 FMN binding site [chemical binding]; other site 1133849002213 substrate binding site [chemical binding]; other site 1133849002214 putative catalytic residue [active] 1133849002215 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1133849002216 Peptidase family M23; Region: Peptidase_M23; pfam01551 1133849002217 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849002218 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1133849002219 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849002220 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1133849002221 acyl-activating enzyme (AAE) consensus motif; other site 1133849002222 AMP binding site [chemical binding]; other site 1133849002223 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849002224 Condensation domain; Region: Condensation; pfam00668 1133849002225 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849002226 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849002227 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849002228 acyl-activating enzyme (AAE) consensus motif; other site 1133849002229 AMP binding site [chemical binding]; other site 1133849002230 Condensation domain; Region: Condensation; pfam00668 1133849002231 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849002232 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849002233 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849002234 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849002235 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1133849002236 acyl-activating enzyme (AAE) consensus motif; other site 1133849002237 AMP binding site [chemical binding]; other site 1133849002238 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849002239 Condensation domain; Region: Condensation; pfam00668 1133849002240 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849002241 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849002242 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849002243 acyl-activating enzyme (AAE) consensus motif; other site 1133849002244 AMP binding site [chemical binding]; other site 1133849002245 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849002246 Condensation domain; Region: Condensation; pfam00668 1133849002247 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849002248 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849002249 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849002250 acyl-activating enzyme (AAE) consensus motif; other site 1133849002251 AMP binding site [chemical binding]; other site 1133849002252 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849002253 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1133849002254 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849002255 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849002256 acyl-activating enzyme (AAE) consensus motif; other site 1133849002257 AMP binding site [chemical binding]; other site 1133849002258 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849002259 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849002260 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1133849002261 acyl-activating enzyme (AAE) consensus motif; other site 1133849002262 AMP binding site [chemical binding]; other site 1133849002263 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849002264 Condensation domain; Region: Condensation; pfam00668 1133849002265 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849002266 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849002267 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849002268 acyl-activating enzyme (AAE) consensus motif; other site 1133849002269 AMP binding site [chemical binding]; other site 1133849002270 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849002271 peptide synthase; Provisional; Region: PRK12467 1133849002272 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849002273 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849002274 acyl-activating enzyme (AAE) consensus motif; other site 1133849002275 AMP binding site [chemical binding]; other site 1133849002276 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849002277 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849002278 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849002279 acyl-activating enzyme (AAE) consensus motif; other site 1133849002280 AMP binding site [chemical binding]; other site 1133849002281 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1133849002282 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849002283 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849002284 acyl-activating enzyme (AAE) consensus motif; other site 1133849002285 AMP binding site [chemical binding]; other site 1133849002286 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849002287 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1133849002288 Putative esterase; Region: Esterase; pfam00756 1133849002289 manganese transport protein MntH; Reviewed; Region: PRK00701 1133849002290 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1133849002291 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1133849002292 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 1133849002293 putative NAD(P) binding site [chemical binding]; other site 1133849002294 putative substrate binding site [chemical binding]; other site 1133849002295 active site 1133849002296 enoyl-CoA hydratase; Provisional; Region: PRK06688 1133849002297 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1133849002298 substrate binding site [chemical binding]; other site 1133849002299 oxyanion hole (OAH) forming residues; other site 1133849002300 trimer interface [polypeptide binding]; other site 1133849002301 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849002302 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849002303 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849002304 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1133849002305 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 1133849002306 NAD(P) binding site [chemical binding]; other site 1133849002307 catalytic residues [active] 1133849002308 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1133849002309 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849002310 Walker A/P-loop; other site 1133849002311 ATP binding site [chemical binding]; other site 1133849002312 Q-loop/lid; other site 1133849002313 ABC transporter signature motif; other site 1133849002314 Walker B; other site 1133849002315 D-loop; other site 1133849002316 H-loop/switch region; other site 1133849002317 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1133849002318 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1133849002319 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1133849002320 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1133849002321 lycopene cyclase; Region: lycopene_cycl; TIGR01789 1133849002322 Putative esterase; Region: Esterase; pfam00756 1133849002323 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1133849002324 Lipase (class 2); Region: Lipase_2; pfam01674 1133849002325 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1133849002326 CoenzymeA binding site [chemical binding]; other site 1133849002327 subunit interaction site [polypeptide binding]; other site 1133849002328 PHB binding site; other site 1133849002329 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1133849002330 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1133849002331 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1133849002332 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1133849002333 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1133849002334 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1133849002335 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1133849002336 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1133849002337 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1133849002338 protein-rRNA interface [nucleotide binding]; other site 1133849002339 putative translocon binding site; other site 1133849002340 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1133849002341 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1133849002342 G-X-X-G motif; other site 1133849002343 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1133849002344 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1133849002345 23S rRNA interface [nucleotide binding]; other site 1133849002346 5S rRNA interface [nucleotide binding]; other site 1133849002347 putative antibiotic binding site [chemical binding]; other site 1133849002348 L25 interface [polypeptide binding]; other site 1133849002349 L27 interface [polypeptide binding]; other site 1133849002350 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1133849002351 putative translocon interaction site; other site 1133849002352 signal recognition particle (SRP54) interaction site; other site 1133849002353 L23 interface [polypeptide binding]; other site 1133849002354 trigger factor interaction site; other site 1133849002355 23S rRNA interface [nucleotide binding]; other site 1133849002356 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1133849002357 PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855 1133849002358 putative active site [active] 1133849002359 EXLDI protein; Region: EXLDI; TIGR04342 1133849002360 MMPL family; Region: MMPL; pfam03176 1133849002361 MMPL family; Region: MMPL; pfam03176 1133849002362 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1133849002363 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1133849002364 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 1133849002365 probable active site [active] 1133849002366 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 1133849002367 PPOX class probable F420-dependent enzyme, Rv3369 family; Region: Rv3369; TIGR03667 1133849002368 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1133849002369 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1133849002370 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849002371 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1133849002372 Walker A/P-loop; other site 1133849002373 ATP binding site [chemical binding]; other site 1133849002374 Q-loop/lid; other site 1133849002375 ABC transporter signature motif; other site 1133849002376 Walker B; other site 1133849002377 D-loop; other site 1133849002378 H-loop/switch region; other site 1133849002379 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1133849002380 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1133849002381 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849002382 Walker A/P-loop; other site 1133849002383 ATP binding site [chemical binding]; other site 1133849002384 Q-loop/lid; other site 1133849002385 ABC transporter signature motif; other site 1133849002386 Walker B; other site 1133849002387 D-loop; other site 1133849002388 H-loop/switch region; other site 1133849002389 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 1133849002390 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 1133849002391 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1133849002392 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1133849002393 FAD binding pocket [chemical binding]; other site 1133849002394 FAD binding motif [chemical binding]; other site 1133849002395 phosphate binding motif [ion binding]; other site 1133849002396 NAD binding pocket [chemical binding]; other site 1133849002397 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1133849002398 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1133849002399 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 1133849002400 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 1133849002401 active site 1133849002402 substrate binding site [chemical binding]; other site 1133849002403 cosubstrate binding site; other site 1133849002404 catalytic site [active] 1133849002405 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 1133849002406 Condensation domain; Region: Condensation; pfam00668 1133849002407 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849002408 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849002409 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849002410 acyl-activating enzyme (AAE) consensus motif; other site 1133849002411 AMP binding site [chemical binding]; other site 1133849002412 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849002413 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849002414 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1133849002415 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1133849002416 intersubunit interface [polypeptide binding]; other site 1133849002417 Condensation domain; Region: Condensation; pfam00668 1133849002418 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849002419 Condensation domain; Region: Condensation; pfam00668 1133849002420 AMP-binding enzyme; Region: AMP-binding; pfam00501 1133849002421 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849002422 acyl-activating enzyme (AAE) consensus motif; other site 1133849002423 AMP binding site [chemical binding]; other site 1133849002424 Condensation domain; Region: Condensation; pfam00668 1133849002425 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1133849002426 Condensation domain; Region: Condensation; pfam00668 1133849002427 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1133849002428 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1133849002429 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1133849002430 acyl-activating enzyme (AAE) consensus motif; other site 1133849002431 AMP binding site [chemical binding]; other site 1133849002432 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849002433 Condensation domain; Region: Condensation; pfam00668 1133849002434 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849002435 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849002436 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1133849002437 acyl-activating enzyme (AAE) consensus motif; other site 1133849002438 AMP binding site [chemical binding]; other site 1133849002439 Condensation domain; Region: Condensation; pfam00668 1133849002440 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1133849002441 Condensation domain; Region: Condensation; pfam00668 1133849002442 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849002443 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1133849002444 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1133849002445 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1133849002446 active site 1133849002447 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1133849002448 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1133849002449 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1133849002450 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1133849002451 NADP binding site [chemical binding]; other site 1133849002452 active site 1133849002453 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1133849002454 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849002455 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1133849002456 Walker A/P-loop; other site 1133849002457 ATP binding site [chemical binding]; other site 1133849002458 Q-loop/lid; other site 1133849002459 ABC transporter signature motif; other site 1133849002460 Walker B; other site 1133849002461 D-loop; other site 1133849002462 H-loop/switch region; other site 1133849002463 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1133849002464 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1133849002465 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1133849002466 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1133849002467 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1133849002468 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1133849002469 intersubunit interface [polypeptide binding]; other site 1133849002470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849002471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849002472 putative substrate translocation pore; other site 1133849002473 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1133849002474 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1133849002475 active site 1133849002476 Zn binding site [ion binding]; other site 1133849002477 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1133849002478 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1133849002479 active site 1133849002480 Zn binding site [ion binding]; other site 1133849002481 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1133849002482 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1133849002483 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1133849002484 RNA binding site [nucleotide binding]; other site 1133849002485 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1133849002486 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1133849002487 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1133849002488 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1133849002489 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1133849002490 putative active site [active] 1133849002491 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1133849002492 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1133849002493 The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424 1133849002494 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1133849002495 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1133849002496 Coenzyme A binding pocket [chemical binding]; other site 1133849002497 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1133849002498 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1133849002499 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1133849002500 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1133849002501 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1133849002502 5S rRNA interface [nucleotide binding]; other site 1133849002503 L27 interface [polypeptide binding]; other site 1133849002504 23S rRNA interface [nucleotide binding]; other site 1133849002505 L5 interface [polypeptide binding]; other site 1133849002506 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1133849002507 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1133849002508 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1133849002509 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1133849002510 23S rRNA binding site [nucleotide binding]; other site 1133849002511 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1133849002512 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1133849002513 SecY translocase; Region: SecY; pfam00344 1133849002514 adenylate kinase; Reviewed; Region: adk; PRK00279 1133849002515 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1133849002516 AMP-binding site [chemical binding]; other site 1133849002517 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1133849002518 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1133849002519 active site 1133849002520 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849002521 S-adenosylmethionine binding site [chemical binding]; other site 1133849002522 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 1133849002523 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1133849002524 putative active site [active] 1133849002525 dimerization interface [polypeptide binding]; other site 1133849002526 putative tRNAtyr binding site [nucleotide binding]; other site 1133849002527 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1133849002528 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1133849002529 active site 1133849002530 ATP binding site [chemical binding]; other site 1133849002531 substrate binding site [chemical binding]; other site 1133849002532 activation loop (A-loop); other site 1133849002533 ethanolamine permease; Region: 2A0305; TIGR00908 1133849002534 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1133849002535 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1133849002536 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1133849002537 DNA binding residues [nucleotide binding] 1133849002538 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1133849002539 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1133849002540 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1133849002541 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1133849002542 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 1133849002543 cell division protein DamX; Validated; Region: PRK10905 1133849002544 EspG family; Region: ESX-1_EspG; pfam14011 1133849002545 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 1133849002546 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1133849002547 PPE family; Region: PPE; pfam00823 1133849002548 EspG family; Region: ESX-1_EspG; pfam14011 1133849002549 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1133849002550 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1133849002551 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 1133849002552 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1133849002553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1133849002554 Walker A motif; other site 1133849002555 ATP binding site [chemical binding]; other site 1133849002556 Walker B motif; other site 1133849002557 arginine finger; other site 1133849002558 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1133849002559 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1133849002560 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1133849002561 active site 1133849002562 catalytic residues [active] 1133849002563 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1133849002564 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1133849002565 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1133849002566 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1133849002567 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1133849002568 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1133849002569 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1133849002570 Coenzyme A binding pocket [chemical binding]; other site 1133849002571 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1133849002572 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1133849002573 DNA-binding site [nucleotide binding]; DNA binding site 1133849002574 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1133849002575 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 1133849002576 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1133849002577 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1133849002578 rRNA binding site [nucleotide binding]; other site 1133849002579 predicted 30S ribosome binding site; other site 1133849002580 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1133849002581 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1133849002582 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1133849002583 30S ribosomal protein S11; Validated; Region: PRK05309 1133849002584 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1133849002585 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1133849002586 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1133849002587 RNA binding surface [nucleotide binding]; other site 1133849002588 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1133849002589 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1133849002590 alphaNTD - beta interaction site [polypeptide binding]; other site 1133849002591 alphaNTD homodimer interface [polypeptide binding]; other site 1133849002592 alphaNTD - beta' interaction site [polypeptide binding]; other site 1133849002593 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1133849002594 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1133849002595 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1133849002596 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1133849002597 dimerization interface 3.5A [polypeptide binding]; other site 1133849002598 active site 1133849002599 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1133849002600 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1133849002601 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1133849002602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849002603 putative substrate translocation pore; other site 1133849002604 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1133849002605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849002606 active site 1133849002607 phosphorylation site [posttranslational modification] 1133849002608 intermolecular recognition site; other site 1133849002609 dimerization interface [polypeptide binding]; other site 1133849002610 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1133849002611 DNA binding site [nucleotide binding] 1133849002612 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1133849002613 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1133849002614 dimer interface [polypeptide binding]; other site 1133849002615 phosphorylation site [posttranslational modification] 1133849002616 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849002617 ATP binding site [chemical binding]; other site 1133849002618 Mg2+ binding site [ion binding]; other site 1133849002619 G-X-G motif; other site 1133849002620 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1133849002621 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1133849002622 substrate binding pocket [chemical binding]; other site 1133849002623 membrane-bound complex binding site; other site 1133849002624 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1133849002625 putative homodimer interface [polypeptide binding]; other site 1133849002626 putative homotetramer interface [polypeptide binding]; other site 1133849002627 putative allosteric switch controlling residues; other site 1133849002628 putative metal binding site [ion binding]; other site 1133849002629 putative homodimer-homodimer interface [polypeptide binding]; other site 1133849002630 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 1133849002631 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1133849002632 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849002633 NAD(P) binding site [chemical binding]; other site 1133849002634 active site 1133849002635 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1133849002636 Predicted flavoprotein [General function prediction only]; Region: COG0431 1133849002637 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1133849002638 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 1133849002639 Ion channel; Region: Ion_trans_2; pfam07885 1133849002640 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 1133849002641 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1133849002642 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1133849002643 active site 1133849002644 catalytic residues [active] 1133849002645 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1133849002646 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1133849002647 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1133849002648 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1133849002649 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1133849002650 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1133849002651 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1133849002652 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1133849002653 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1133849002654 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1133849002655 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1133849002656 active site 1133849002657 ATP binding site [chemical binding]; other site 1133849002658 substrate binding site [chemical binding]; other site 1133849002659 activation loop (A-loop); other site 1133849002660 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1133849002661 phosphopeptide binding site; other site 1133849002662 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1133849002663 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1133849002664 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1133849002665 phosphopeptide binding site; other site 1133849002666 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1133849002667 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1133849002668 phosphopeptide binding site; other site 1133849002669 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1133849002670 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1133849002671 Walker A/P-loop; other site 1133849002672 ATP binding site [chemical binding]; other site 1133849002673 Q-loop/lid; other site 1133849002674 ABC transporter signature motif; other site 1133849002675 Walker B; other site 1133849002676 D-loop; other site 1133849002677 H-loop/switch region; other site 1133849002678 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1133849002679 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1133849002680 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1133849002681 23S rRNA interface [nucleotide binding]; other site 1133849002682 L3 interface [polypeptide binding]; other site 1133849002683 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1133849002684 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1133849002685 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1133849002686 active site 1133849002687 substrate binding site [chemical binding]; other site 1133849002688 metal binding site [ion binding]; metal-binding site 1133849002689 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1133849002690 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849002691 Walker A/P-loop; other site 1133849002692 ATP binding site [chemical binding]; other site 1133849002693 Q-loop/lid; other site 1133849002694 ABC transporter signature motif; other site 1133849002695 Walker B; other site 1133849002696 D-loop; other site 1133849002697 H-loop/switch region; other site 1133849002698 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1133849002699 PspC domain; Region: PspC; pfam04024 1133849002700 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1133849002701 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1133849002702 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1133849002703 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1133849002704 glutaminase active site [active] 1133849002705 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1133849002706 dimer interface [polypeptide binding]; other site 1133849002707 active site 1133849002708 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1133849002709 dimer interface [polypeptide binding]; other site 1133849002710 active site 1133849002711 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1133849002712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849002713 putative substrate translocation pore; other site 1133849002714 MarR family; Region: MarR; pfam01047 1133849002715 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 1133849002716 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1133849002717 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1133849002718 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1133849002719 alanine racemase; Reviewed; Region: alr; PRK00053 1133849002720 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1133849002721 active site 1133849002722 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1133849002723 dimer interface [polypeptide binding]; other site 1133849002724 substrate binding site [chemical binding]; other site 1133849002725 catalytic residues [active] 1133849002726 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849002727 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1133849002728 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1133849002729 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 1133849002730 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1133849002731 Glycoprotease family; Region: Peptidase_M22; pfam00814 1133849002732 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1133849002733 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1133849002734 Coenzyme A binding pocket [chemical binding]; other site 1133849002735 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1133849002736 UGMP family protein; Validated; Region: PRK09604 1133849002737 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1133849002738 nucleotide binding site [chemical binding]; other site 1133849002739 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1133849002740 oligomerisation interface [polypeptide binding]; other site 1133849002741 mobile loop; other site 1133849002742 roof hairpin; other site 1133849002743 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1133849002744 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1133849002745 ring oligomerisation interface [polypeptide binding]; other site 1133849002746 ATP/Mg binding site [chemical binding]; other site 1133849002747 stacking interactions; other site 1133849002748 hinge regions; other site 1133849002749 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 1133849002750 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849002751 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1133849002752 DNA binding residues [nucleotide binding] 1133849002753 Transcription factor WhiB; Region: Whib; pfam02467 1133849002754 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1133849002755 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849002756 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1133849002757 DNA binding residues [nucleotide binding] 1133849002758 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1133849002759 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1133849002760 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1133849002761 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1133849002762 active site 1133849002763 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1133849002764 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1133849002765 active site 1133849002766 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1133849002767 GMP synthase; Reviewed; Region: guaA; PRK00074 1133849002768 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1133849002769 AMP/PPi binding site [chemical binding]; other site 1133849002770 candidate oxyanion hole; other site 1133849002771 catalytic triad [active] 1133849002772 potential glutamine specificity residues [chemical binding]; other site 1133849002773 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1133849002774 ATP Binding subdomain [chemical binding]; other site 1133849002775 Ligand Binding sites [chemical binding]; other site 1133849002776 Dimerization subdomain; other site 1133849002777 PspC domain; Region: PspC; pfam04024 1133849002778 PspC domain; Region: PspC; pfam04024 1133849002779 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1133849002780 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849002781 ATP binding site [chemical binding]; other site 1133849002782 Mg2+ binding site [ion binding]; other site 1133849002783 G-X-G motif; other site 1133849002784 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849002785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849002786 active site 1133849002787 phosphorylation site [posttranslational modification] 1133849002788 intermolecular recognition site; other site 1133849002789 dimerization interface [polypeptide binding]; other site 1133849002790 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849002791 DNA binding residues [nucleotide binding] 1133849002792 dimerization interface [polypeptide binding]; other site 1133849002793 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1133849002794 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1133849002795 active site 1133849002796 ATP binding site [chemical binding]; other site 1133849002797 substrate binding site [chemical binding]; other site 1133849002798 activation loop (A-loop); other site 1133849002799 DNA Polymerase Y-family; Region: PolY_like; cd03468 1133849002800 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849002801 S-adenosylmethionine binding site [chemical binding]; other site 1133849002802 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849002803 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1133849002804 classical (c) SDRs; Region: SDR_c; cd05233 1133849002805 NAD(P) binding site [chemical binding]; other site 1133849002806 active site 1133849002807 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1133849002808 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1133849002809 active site 1133849002810 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1133849002811 generic binding surface II; other site 1133849002812 generic binding surface I; other site 1133849002813 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 1133849002814 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 1133849002815 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1133849002816 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1133849002817 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1133849002818 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1133849002819 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1133849002820 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849002821 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1133849002822 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1133849002823 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 1133849002824 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1133849002825 homodimer interface [polypeptide binding]; other site 1133849002826 substrate-cofactor binding pocket; other site 1133849002827 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849002828 catalytic residue [active] 1133849002829 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1133849002830 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849002831 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849002832 isocitrate dehydrogenase; Validated; Region: PRK08299 1133849002833 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1133849002834 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1133849002835 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1133849002836 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1133849002837 conserved cys residue [active] 1133849002838 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849002839 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849002840 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1133849002841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849002842 putative substrate translocation pore; other site 1133849002843 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849002844 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849002845 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1133849002846 lipid-transfer protein; Provisional; Region: PRK08256 1133849002847 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1133849002848 active site 1133849002849 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1133849002850 hydrophobic ligand binding site; other site 1133849002851 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1133849002852 active site 1133849002853 catalytic site [active] 1133849002854 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1133849002855 active site 2 [active] 1133849002856 active site 1 [active] 1133849002857 short chain dehydrogenase; Provisional; Region: PRK07791 1133849002858 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849002859 NAD(P) binding site [chemical binding]; other site 1133849002860 active site 1133849002861 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849002862 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849002863 active site 1133849002864 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849002865 B-Box C-terminal domain; Region: BBC; smart00502 1133849002866 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849002867 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1133849002868 putative active site [active] 1133849002869 putative catalytic site [active] 1133849002870 putative DNA binding site [nucleotide binding]; other site 1133849002871 putative phosphate binding site [ion binding]; other site 1133849002872 metal binding site A [ion binding]; metal-binding site 1133849002873 putative AP binding site [nucleotide binding]; other site 1133849002874 putative metal binding site B [ion binding]; other site 1133849002875 ribonuclease; Region: Ribonuclease; pfam00545 1133849002876 active site 1133849002877 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 1133849002878 putative RNAase interaction site [polypeptide binding]; other site 1133849002879 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849002880 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849002881 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1133849002882 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1133849002883 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1133849002884 active site 1133849002885 HIGH motif; other site 1133849002886 dimer interface [polypeptide binding]; other site 1133849002887 KMSKS motif; other site 1133849002888 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1133849002889 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1133849002890 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1133849002891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849002892 putative substrate translocation pore; other site 1133849002893 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1133849002894 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849002895 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 1133849002896 cofactor binding site; other site 1133849002897 metal binding site [ion binding]; metal-binding site 1133849002898 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1133849002899 TAP-like protein; Region: Abhydrolase_4; pfam08386 1133849002900 hypothetical protein; Reviewed; Region: PRK00024 1133849002901 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1133849002902 MPN+ (JAMM) motif; other site 1133849002903 Zinc-binding site [ion binding]; other site 1133849002904 PhoD-like phosphatase; Region: PhoD; pfam09423 1133849002905 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1133849002906 putative active site [active] 1133849002907 putative metal binding site [ion binding]; other site 1133849002908 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1133849002909 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1133849002910 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1133849002911 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1133849002912 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 1133849002913 L-aspartate oxidase; Provisional; Region: PRK06175 1133849002914 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1133849002915 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 1133849002916 putative Iron-sulfur protein interface [polypeptide binding]; other site 1133849002917 putative proximal heme binding site [chemical binding]; other site 1133849002918 putative SdhC-like subunit interface [polypeptide binding]; other site 1133849002919 putative distal heme binding site [chemical binding]; other site 1133849002920 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 1133849002921 putative Iron-sulfur protein interface [polypeptide binding]; other site 1133849002922 putative proximal heme binding site [chemical binding]; other site 1133849002923 putative SdhD-like interface [polypeptide binding]; other site 1133849002924 putative distal heme binding site [chemical binding]; other site 1133849002925 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1133849002926 active site 1133849002927 catalytic motif [active] 1133849002928 Zn binding site [ion binding]; other site 1133849002929 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1133849002930 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1133849002931 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1133849002932 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1133849002933 adenosine deaminase; Provisional; Region: PRK09358 1133849002934 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1133849002935 active site 1133849002936 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1133849002937 NlpC/P60 family; Region: NLPC_P60; pfam00877 1133849002938 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1133849002939 active site 1133849002940 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1133849002941 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1133849002942 active site 1133849002943 substrate binding site [chemical binding]; other site 1133849002944 metal binding site [ion binding]; metal-binding site 1133849002945 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1133849002946 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1133849002947 substrate binding site [chemical binding]; other site 1133849002948 oxyanion hole (OAH) forming residues; other site 1133849002949 trimer interface [polypeptide binding]; other site 1133849002950 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1133849002951 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1133849002952 metal binding site [ion binding]; metal-binding site 1133849002953 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1133849002954 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1133849002955 metal binding site [ion binding]; metal-binding site 1133849002956 putative dimer interface [polypeptide binding]; other site 1133849002957 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1133849002958 putative active site pocket [active] 1133849002959 dimerization interface [polypeptide binding]; other site 1133849002960 putative catalytic residue [active] 1133849002961 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1133849002962 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1133849002963 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1133849002964 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1133849002965 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 1133849002966 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1133849002967 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1133849002968 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849002969 homodimer interface [polypeptide binding]; other site 1133849002970 catalytic residue [active] 1133849002971 glycerol kinase; Provisional; Region: glpK; PRK00047 1133849002972 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 1133849002973 N- and C-terminal domain interface [polypeptide binding]; other site 1133849002974 active site 1133849002975 MgATP binding site [chemical binding]; other site 1133849002976 catalytic site [active] 1133849002977 metal binding site [ion binding]; metal-binding site 1133849002978 putative homotetramer interface [polypeptide binding]; other site 1133849002979 glycerol binding site [chemical binding]; other site 1133849002980 homodimer interface [polypeptide binding]; other site 1133849002981 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1133849002982 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1133849002983 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1133849002984 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1133849002985 dimer interface [polypeptide binding]; other site 1133849002986 phosphorylation site [posttranslational modification] 1133849002987 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849002988 ATP binding site [chemical binding]; other site 1133849002989 Mg2+ binding site [ion binding]; other site 1133849002990 G-X-G motif; other site 1133849002991 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1133849002992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849002993 active site 1133849002994 phosphorylation site [posttranslational modification] 1133849002995 intermolecular recognition site; other site 1133849002996 dimerization interface [polypeptide binding]; other site 1133849002997 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1133849002998 DNA binding site [nucleotide binding] 1133849002999 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 1133849003000 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1133849003001 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1133849003002 putative DNA binding site [nucleotide binding]; other site 1133849003003 catalytic residue [active] 1133849003004 putative H2TH interface [polypeptide binding]; other site 1133849003005 putative catalytic residues [active] 1133849003006 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1133849003007 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1133849003008 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1133849003009 ATP binding site [chemical binding]; other site 1133849003010 putative Mg++ binding site [ion binding]; other site 1133849003011 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1133849003012 nucleotide binding region [chemical binding]; other site 1133849003013 ATP-binding site [chemical binding]; other site 1133849003014 DEAD/H associated; Region: DEAD_assoc; pfam08494 1133849003015 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1133849003016 catalytic core [active] 1133849003017 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849003018 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849003019 Patatin-like phospholipase; Region: Patatin; pfam01734 1133849003020 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1133849003021 short chain dehydrogenase; Provisional; Region: PRK07825 1133849003022 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849003023 NAD(P) binding site [chemical binding]; other site 1133849003024 active site 1133849003025 Secretory lipase; Region: LIP; pfam03583 1133849003026 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 1133849003027 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1133849003028 dimer interface [polypeptide binding]; other site 1133849003029 PYR/PP interface [polypeptide binding]; other site 1133849003030 TPP binding site [chemical binding]; other site 1133849003031 substrate binding site [chemical binding]; other site 1133849003032 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1133849003033 TPP-binding site [chemical binding]; other site 1133849003034 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 1133849003035 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1133849003036 dimerization interface [polypeptide binding]; other site 1133849003037 DNA binding residues [nucleotide binding] 1133849003038 Protein of unknown function (DUF2283); Region: DUF2283; cl02251 1133849003039 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1133849003040 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 1133849003041 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1133849003042 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849003043 Walker A/P-loop; other site 1133849003044 ATP binding site [chemical binding]; other site 1133849003045 Q-loop/lid; other site 1133849003046 ABC transporter signature motif; other site 1133849003047 Walker B; other site 1133849003048 D-loop; other site 1133849003049 H-loop/switch region; other site 1133849003050 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1133849003051 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1133849003052 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1133849003053 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849003054 Walker A/P-loop; other site 1133849003055 ATP binding site [chemical binding]; other site 1133849003056 Q-loop/lid; other site 1133849003057 ABC transporter signature motif; other site 1133849003058 Walker B; other site 1133849003059 D-loop; other site 1133849003060 H-loop/switch region; other site 1133849003061 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 1133849003062 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1133849003063 active site 1133849003064 zinc binding site [ion binding]; other site 1133849003065 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 1133849003066 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 1133849003067 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 1133849003068 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1133849003069 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849003070 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1133849003071 DNA binding residues [nucleotide binding] 1133849003072 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1133849003073 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849003074 Walker A/P-loop; other site 1133849003075 ATP binding site [chemical binding]; other site 1133849003076 Q-loop/lid; other site 1133849003077 ABC transporter signature motif; other site 1133849003078 Walker B; other site 1133849003079 D-loop; other site 1133849003080 H-loop/switch region; other site 1133849003081 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1133849003082 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1133849003083 active site 1133849003084 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 1133849003085 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1133849003086 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 1133849003087 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849003088 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1133849003089 putative substrate translocation pore; other site 1133849003090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849003091 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1133849003092 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1133849003093 active site 1133849003094 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1133849003095 catalytic triad [active] 1133849003096 dimer interface [polypeptide binding]; other site 1133849003097 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1133849003098 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849003099 Cytochrome P450; Region: p450; cl12078 1133849003100 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1133849003101 aldehyde dehydrogenase family 7 member; Region: PLN02315 1133849003102 tetrameric interface [polypeptide binding]; other site 1133849003103 NAD binding site [chemical binding]; other site 1133849003104 catalytic residues [active] 1133849003105 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1133849003106 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1133849003107 putative DNA binding site [nucleotide binding]; other site 1133849003108 putative Zn2+ binding site [ion binding]; other site 1133849003109 AsnC family; Region: AsnC_trans_reg; pfam01037 1133849003110 L-lysine aminotransferase; Provisional; Region: PRK08297 1133849003111 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1133849003112 inhibitor-cofactor binding pocket; inhibition site 1133849003113 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849003114 catalytic residue [active] 1133849003115 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1133849003116 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1133849003117 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1133849003118 active site 1133849003119 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1133849003120 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1133849003121 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1133849003122 active site 1133849003123 ATP binding site [chemical binding]; other site 1133849003124 substrate binding site [chemical binding]; other site 1133849003125 activation loop (A-loop); other site 1133849003126 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1133849003127 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1133849003128 active site 1133849003129 ATP binding site [chemical binding]; other site 1133849003130 substrate binding site [chemical binding]; other site 1133849003131 activation loop (A-loop); other site 1133849003132 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1133849003133 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1133849003134 active site 1133849003135 nucleophile elbow; other site 1133849003136 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1133849003137 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1133849003138 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1133849003139 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1133849003140 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1133849003141 carboxyltransferase (CT) interaction site; other site 1133849003142 biotinylation site [posttranslational modification]; other site 1133849003143 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1133849003144 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1133849003145 active site residue [active] 1133849003146 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1133849003147 active site residue [active] 1133849003148 Predicted transcriptional regulator [Transcription]; Region: COG2345 1133849003149 Helix-turn-helix domain; Region: HTH_20; pfam12840 1133849003150 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1133849003151 active site 1133849003152 dimer interface [polypeptide binding]; other site 1133849003153 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 1133849003154 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1133849003155 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1133849003156 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1133849003157 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1133849003158 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1133849003159 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1133849003160 Bacterial PH domain; Region: DUF304; pfam03703 1133849003161 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1133849003162 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849003163 active site 1133849003164 phosphorylation site [posttranslational modification] 1133849003165 intermolecular recognition site; other site 1133849003166 dimerization interface [polypeptide binding]; other site 1133849003167 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1133849003168 DNA binding site [nucleotide binding] 1133849003169 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1133849003170 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1133849003171 dimer interface [polypeptide binding]; other site 1133849003172 phosphorylation site [posttranslational modification] 1133849003173 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849003174 ATP binding site [chemical binding]; other site 1133849003175 Mg2+ binding site [ion binding]; other site 1133849003176 G-X-G motif; other site 1133849003177 Predicted membrane protein [Function unknown]; Region: COG2246 1133849003178 GtrA-like protein; Region: GtrA; pfam04138 1133849003179 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1133849003180 ATP-grasp domain; Region: ATP-grasp; pfam02222 1133849003181 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1133849003182 PIN domain; Region: PIN_3; pfam13470 1133849003183 DNA binding domain, excisionase family; Region: excise; TIGR01764 1133849003184 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849003185 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849003186 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849003187 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1133849003188 FAD binding site [chemical binding]; other site 1133849003189 homotetramer interface [polypeptide binding]; other site 1133849003190 substrate binding pocket [chemical binding]; other site 1133849003191 catalytic base [active] 1133849003192 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1133849003193 Part of AAA domain; Region: AAA_19; pfam13245 1133849003194 Family description; Region: UvrD_C_2; pfam13538 1133849003195 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1133849003196 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849003197 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1133849003198 FAD binding domain; Region: FAD_binding_4; pfam01565 1133849003199 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1133849003200 Predicted membrane protein [Function unknown]; Region: COG2246 1133849003201 GtrA-like protein; Region: GtrA; pfam04138 1133849003202 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1133849003203 conserved cys residue [active] 1133849003204 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1133849003205 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1133849003206 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1133849003207 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1133849003208 HIT family signature motif; other site 1133849003209 catalytic residue [active] 1133849003210 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1133849003211 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1133849003212 ligand binding site [chemical binding]; other site 1133849003213 homodimer interface [polypeptide binding]; other site 1133849003214 NAD(P) binding site [chemical binding]; other site 1133849003215 trimer interface B [polypeptide binding]; other site 1133849003216 trimer interface A [polypeptide binding]; other site 1133849003217 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1133849003218 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1133849003219 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1133849003220 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1133849003221 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1133849003222 Walker A motif; other site 1133849003223 ATP binding site [chemical binding]; other site 1133849003224 Walker B motif; other site 1133849003225 arginine finger; other site 1133849003226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849003227 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1133849003228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849003229 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849003230 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1133849003231 NAD(P) binding site [chemical binding]; other site 1133849003232 active site 1133849003233 Cupin; Region: Cupin_6; pfam12852 1133849003234 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849003235 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1133849003236 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849003237 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1133849003238 active site 1133849003239 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1133849003240 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1133849003241 E3 interaction surface; other site 1133849003242 lipoyl attachment site [posttranslational modification]; other site 1133849003243 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1133849003244 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1133849003245 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1133849003246 alpha subunit interface [polypeptide binding]; other site 1133849003247 TPP binding site [chemical binding]; other site 1133849003248 heterodimer interface [polypeptide binding]; other site 1133849003249 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1133849003250 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1133849003251 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1133849003252 TPP-binding site [chemical binding]; other site 1133849003253 tetramer interface [polypeptide binding]; other site 1133849003254 heterodimer interface [polypeptide binding]; other site 1133849003255 phosphorylation loop region [posttranslational modification] 1133849003256 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1133849003257 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1133849003258 dimerization interface [polypeptide binding]; other site 1133849003259 putative DNA binding site [nucleotide binding]; other site 1133849003260 putative Zn2+ binding site [ion binding]; other site 1133849003261 AsnC family; Region: AsnC_trans_reg; pfam01037 1133849003262 classical (c) SDRs; Region: SDR_c; cd05233 1133849003263 NAD(P) binding site [chemical binding]; other site 1133849003264 active site 1133849003265 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1133849003266 xanthine permease; Region: pbuX; TIGR03173 1133849003267 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 1133849003268 benzoate transporter; Region: benE; TIGR00843 1133849003269 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1133849003270 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1133849003271 active site residue [active] 1133849003272 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1133849003273 active site residue [active] 1133849003274 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1133849003275 SNF2 Helicase protein; Region: DUF3670; pfam12419 1133849003276 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1133849003277 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1133849003278 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1133849003279 putative Mg++ binding site [ion binding]; other site 1133849003280 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1133849003281 nucleotide binding region [chemical binding]; other site 1133849003282 ATP-binding site [chemical binding]; other site 1133849003283 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1133849003284 SWIM zinc finger; Region: SWIM; pfam04434 1133849003285 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1133849003286 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1133849003287 intersubunit interface [polypeptide binding]; other site 1133849003288 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1133849003289 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1133849003290 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849003291 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1133849003292 B12 binding site [chemical binding]; other site 1133849003293 cobalt ligand [ion binding]; other site 1133849003294 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 1133849003295 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1133849003296 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 1133849003297 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1133849003298 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1133849003299 tetrameric interface [polypeptide binding]; other site 1133849003300 NAD binding site [chemical binding]; other site 1133849003301 catalytic residues [active] 1133849003302 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849003303 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 1133849003304 substrate binding pocket [chemical binding]; other site 1133849003305 FAD binding site [chemical binding]; other site 1133849003306 catalytic base [active] 1133849003307 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1133849003308 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1133849003309 substrate binding site [chemical binding]; other site 1133849003310 oxyanion hole (OAH) forming residues; other site 1133849003311 trimer interface [polypeptide binding]; other site 1133849003312 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1133849003313 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1133849003314 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1133849003315 enoyl-CoA hydratase; Provisional; Region: PRK05862 1133849003316 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1133849003317 substrate binding site [chemical binding]; other site 1133849003318 oxyanion hole (OAH) forming residues; other site 1133849003319 trimer interface [polypeptide binding]; other site 1133849003320 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1133849003321 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1133849003322 MarR family; Region: MarR; pfam01047 1133849003323 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1133849003324 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1133849003325 active site 1133849003326 metal binding site [ion binding]; metal-binding site 1133849003327 CAAX protease self-immunity; Region: Abi; pfam02517 1133849003328 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1133849003329 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1133849003330 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1133849003331 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1133849003332 active site 1133849003333 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1133849003334 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 1133849003335 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1133849003336 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1133849003337 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1133849003338 active site 1133849003339 HIGH motif; other site 1133849003340 KMSK motif region; other site 1133849003341 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1133849003342 tRNA binding surface [nucleotide binding]; other site 1133849003343 anticodon binding site; other site 1133849003344 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1133849003345 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1133849003346 active site 1133849003347 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1133849003348 substrate binding site [chemical binding]; other site 1133849003349 catalytic residues [active] 1133849003350 dimer interface [polypeptide binding]; other site 1133849003351 homoserine dehydrogenase; Provisional; Region: PRK06349 1133849003352 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1133849003353 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1133849003354 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1133849003355 threonine synthase; Reviewed; Region: PRK06721 1133849003356 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1133849003357 homodimer interface [polypeptide binding]; other site 1133849003358 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849003359 catalytic residue [active] 1133849003360 homoserine kinase; Provisional; Region: PRK01212 1133849003361 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1133849003362 transcription termination factor Rho; Provisional; Region: PRK12608 1133849003363 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1133849003364 RNA binding site [nucleotide binding]; other site 1133849003365 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1133849003366 multimer interface [polypeptide binding]; other site 1133849003367 Walker A motif; other site 1133849003368 ATP binding site [chemical binding]; other site 1133849003369 Walker B motif; other site 1133849003370 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1133849003371 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1133849003372 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1133849003373 RF-1 domain; Region: RF-1; pfam00472 1133849003374 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1133849003375 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849003376 S-adenosylmethionine binding site [chemical binding]; other site 1133849003377 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1133849003378 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1133849003379 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1133849003380 Mg++ binding site [ion binding]; other site 1133849003381 putative catalytic motif [active] 1133849003382 substrate binding site [chemical binding]; other site 1133849003383 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1133849003384 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1133849003385 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1133849003386 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1133849003387 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1133849003388 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1133849003389 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1133849003390 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1133849003391 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1133849003392 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1133849003393 beta subunit interaction interface [polypeptide binding]; other site 1133849003394 Walker A motif; other site 1133849003395 ATP binding site [chemical binding]; other site 1133849003396 Walker B motif; other site 1133849003397 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1133849003398 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1133849003399 core domain interface [polypeptide binding]; other site 1133849003400 delta subunit interface [polypeptide binding]; other site 1133849003401 epsilon subunit interface [polypeptide binding]; other site 1133849003402 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1133849003403 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1133849003404 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1133849003405 alpha subunit interaction interface [polypeptide binding]; other site 1133849003406 Walker A motif; other site 1133849003407 ATP binding site [chemical binding]; other site 1133849003408 Walker B motif; other site 1133849003409 inhibitor binding site; inhibition site 1133849003410 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1133849003411 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13444 1133849003412 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1133849003413 gamma subunit interface [polypeptide binding]; other site 1133849003414 epsilon subunit interface [polypeptide binding]; other site 1133849003415 LBP interface [polypeptide binding]; other site 1133849003416 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1133849003417 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1133849003418 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1133849003419 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1133849003420 hinge; other site 1133849003421 active site 1133849003422 MMPL family; Region: MMPL; pfam03176 1133849003423 MMPL family; Region: MMPL; pfam03176 1133849003424 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849003425 NAD(P) binding site [chemical binding]; other site 1133849003426 active site 1133849003427 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1133849003428 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1133849003429 Rubredoxin; Region: Rubredoxin; pfam00301 1133849003430 iron binding site [ion binding]; other site 1133849003431 hypothetical protein; Provisional; Region: PRK03298 1133849003432 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1133849003433 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1133849003434 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849003435 dimer interface [polypeptide binding]; other site 1133849003436 substrate binding site [chemical binding]; other site 1133849003437 putative acyltransferase; Provisional; Region: PRK05790 1133849003438 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1133849003439 dimer interface [polypeptide binding]; other site 1133849003440 active site 1133849003441 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1133849003442 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1133849003443 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1133849003444 glycogen branching enzyme; Provisional; Region: PRK05402 1133849003445 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1133849003446 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1133849003447 active site 1133849003448 catalytic site [active] 1133849003449 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1133849003450 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1133849003451 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1133849003452 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1133849003453 active site 1133849003454 homodimer interface [polypeptide binding]; other site 1133849003455 catalytic site [active] 1133849003456 acceptor binding site [chemical binding]; other site 1133849003457 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1133849003458 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849003459 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849003460 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 1133849003461 putative dimer interface [polypeptide binding]; other site 1133849003462 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849003463 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1133849003464 putative homodimer interface [polypeptide binding]; other site 1133849003465 putative active site pocket [active] 1133849003466 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1133849003467 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1133849003468 Predicted membrane protein [Function unknown]; Region: COG2259 1133849003469 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1133849003470 homotrimer interaction site [polypeptide binding]; other site 1133849003471 putative active site [active] 1133849003472 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1133849003473 EspG family; Region: ESX-1_EspG; pfam14011 1133849003474 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1133849003475 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1133849003476 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1133849003477 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1133849003478 putative Mg++ binding site [ion binding]; other site 1133849003479 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1133849003480 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1133849003481 Isochorismatase family; Region: Isochorismatase; pfam00857 1133849003482 catalytic triad [active] 1133849003483 metal binding site [ion binding]; metal-binding site 1133849003484 conserved cis-peptide bond; other site 1133849003485 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1133849003486 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1133849003487 active site 1133849003488 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1133849003489 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1133849003490 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1133849003491 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1133849003492 cleavage site 1133849003493 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 1133849003494 MPN+ (JAMM) motif; other site 1133849003495 Zinc-binding site [ion binding]; other site 1133849003496 Ubiquitin-like proteins; Region: UBQ; cl00155 1133849003497 charged pocket; other site 1133849003498 hydrophobic patch; other site 1133849003499 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1133849003500 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1133849003501 dimer interface [polypeptide binding]; other site 1133849003502 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849003503 catalytic residue [active] 1133849003504 Rhomboid family; Region: Rhomboid; cl11446 1133849003505 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1133849003506 ribonuclease PH; Reviewed; Region: rph; PRK00173 1133849003507 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1133849003508 hexamer interface [polypeptide binding]; other site 1133849003509 active site 1133849003510 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1133849003511 active site 1133849003512 dimerization interface [polypeptide binding]; other site 1133849003513 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1133849003514 Glucitol operon activator protein (GutM); Region: GutM; cl01890 1133849003515 short chain dehydrogenase; Provisional; Region: PRK06197 1133849003516 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1133849003517 putative NAD(P) binding site [chemical binding]; other site 1133849003518 active site 1133849003519 Secretory lipase; Region: LIP; pfam03583 1133849003520 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849003521 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849003522 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1133849003523 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1133849003524 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 1133849003525 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849003526 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1133849003527 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1133849003528 DNA binding residues [nucleotide binding] 1133849003529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849003530 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1133849003531 putative substrate translocation pore; other site 1133849003532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849003533 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1133849003534 Predicted transcriptional regulators [Transcription]; Region: COG1695 1133849003535 hypothetical protein; Provisional; Region: PRK06847 1133849003536 hypothetical protein; Provisional; Region: PRK07236 1133849003537 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1133849003538 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1133849003539 Walker A/P-loop; other site 1133849003540 ATP binding site [chemical binding]; other site 1133849003541 Q-loop/lid; other site 1133849003542 ABC transporter signature motif; other site 1133849003543 Walker B; other site 1133849003544 D-loop; other site 1133849003545 H-loop/switch region; other site 1133849003546 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1133849003547 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1133849003548 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1133849003549 dimerization interface [polypeptide binding]; other site 1133849003550 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849003551 non-specific DNA binding site [nucleotide binding]; other site 1133849003552 salt bridge; other site 1133849003553 sequence-specific DNA binding site [nucleotide binding]; other site 1133849003554 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1133849003555 haloalkane dehalogenase; Provisional; Region: PRK03592 1133849003556 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1133849003557 catalytic site [active] 1133849003558 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1133849003559 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849003560 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1133849003561 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 1133849003562 gating phenylalanine in ion channel; other site 1133849003563 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1133849003564 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1133849003565 putative dimerization interface [polypeptide binding]; other site 1133849003566 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1133849003567 PhoU domain; Region: PhoU; pfam01895 1133849003568 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1133849003569 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1133849003570 Family description; Region: VCBS; pfam13517 1133849003571 Family description; Region: VCBS; pfam13517 1133849003572 Family description; Region: VCBS; pfam13517 1133849003573 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1133849003574 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 1133849003575 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1133849003576 Permease; Region: Permease; pfam02405 1133849003577 Permease; Region: Permease; pfam02405 1133849003578 mce related protein; Region: MCE; pfam02470 1133849003579 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1133849003580 mce related protein; Region: MCE; pfam02470 1133849003581 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1133849003582 mce related protein; Region: MCE; pfam02470 1133849003583 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1133849003584 mce related protein; Region: MCE; pfam02470 1133849003585 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1133849003586 mce related protein; Region: MCE; pfam02470 1133849003587 mce related protein; Region: MCE; pfam02470 1133849003588 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1133849003589 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 1133849003590 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1133849003591 classical (c) SDRs; Region: SDR_c; cd05233 1133849003592 NAD(P) binding site [chemical binding]; other site 1133849003593 active site 1133849003594 Histidine kinase; Region: HisKA_3; pfam07730 1133849003595 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1133849003596 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849003597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849003598 active site 1133849003599 phosphorylation site [posttranslational modification] 1133849003600 intermolecular recognition site; other site 1133849003601 dimerization interface [polypeptide binding]; other site 1133849003602 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849003603 DNA binding residues [nucleotide binding] 1133849003604 dimerization interface [polypeptide binding]; other site 1133849003605 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849003606 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849003607 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849003608 Cytochrome P450; Region: p450; cl12078 1133849003609 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1133849003610 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849003611 putative DNA binding site [nucleotide binding]; other site 1133849003612 putative Zn2+ binding site [ion binding]; other site 1133849003613 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1133849003614 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1133849003615 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 1133849003616 metal-binding site [ion binding] 1133849003617 cell division protein ZipA; Provisional; Region: PRK03427 1133849003618 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849003619 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849003620 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849003621 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1133849003622 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1133849003623 putative active site [active] 1133849003624 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1133849003625 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1133849003626 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849003627 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1133849003628 DNA binding residues [nucleotide binding] 1133849003629 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849003630 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849003631 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1133849003632 TAP-like protein; Region: Abhydrolase_4; pfam08386 1133849003633 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1133849003634 MarR family; Region: MarR_2; pfam12802 1133849003635 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1133849003636 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 1133849003637 putative NAD(P) binding site [chemical binding]; other site 1133849003638 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1133849003639 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1133849003640 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849003641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849003642 putative substrate translocation pore; other site 1133849003643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849003644 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849003645 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849003646 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1133849003647 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1133849003648 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849003649 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1133849003650 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1133849003651 shikimate kinase; Reviewed; Region: aroK; PRK00131 1133849003652 AAA domain; Region: AAA_17; cl17253 1133849003653 Putative esterase; Region: Esterase; pfam00756 1133849003654 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1133849003655 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1133849003656 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1133849003657 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 1133849003658 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1133849003659 putative ligand binding site [chemical binding]; other site 1133849003660 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1133849003661 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1133849003662 Walker A/P-loop; other site 1133849003663 ATP binding site [chemical binding]; other site 1133849003664 Q-loop/lid; other site 1133849003665 ABC transporter signature motif; other site 1133849003666 Walker B; other site 1133849003667 D-loop; other site 1133849003668 H-loop/switch region; other site 1133849003669 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1133849003670 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1133849003671 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1133849003672 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1133849003673 TM-ABC transporter signature motif; other site 1133849003674 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1133849003675 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1133849003676 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1133849003677 PAS domain S-box; Region: sensory_box; TIGR00229 1133849003678 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1133849003679 putative active site [active] 1133849003680 heme pocket [chemical binding]; other site 1133849003681 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1133849003682 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1133849003683 metal binding site [ion binding]; metal-binding site 1133849003684 active site 1133849003685 I-site; other site 1133849003686 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1133849003687 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1133849003688 FAD binding pocket [chemical binding]; other site 1133849003689 FAD binding motif [chemical binding]; other site 1133849003690 phosphate binding motif [ion binding]; other site 1133849003691 beta-alpha-beta structure motif; other site 1133849003692 NAD(p) ribose binding residues [chemical binding]; other site 1133849003693 NAD binding pocket [chemical binding]; other site 1133849003694 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1133849003695 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1133849003696 catalytic loop [active] 1133849003697 iron binding site [ion binding]; other site 1133849003698 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1133849003699 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1133849003700 NIPSNAP; Region: NIPSNAP; pfam07978 1133849003701 CSLREA domain; Region: CSLREA_Nterm; TIGR04214 1133849003702 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1133849003703 acyltransferase PapA5; Provisional; Region: PRK09294 1133849003704 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849003705 Cytochrome P450; Region: p450; cl12078 1133849003706 acyltransferase PapA5; Provisional; Region: PRK09294 1133849003707 CGNR zinc finger; Region: zf-CGNR; pfam11706 1133849003708 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 1133849003709 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 1133849003710 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1133849003711 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1133849003712 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1133849003713 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849003714 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1133849003715 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849003716 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1133849003717 NAD(P) binding site [chemical binding]; other site 1133849003718 active site 1133849003719 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849003720 dimerization interface [polypeptide binding]; other site 1133849003721 putative Zn2+ binding site [ion binding]; other site 1133849003722 putative DNA binding site [nucleotide binding]; other site 1133849003723 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1133849003724 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1133849003725 nucleotide binding site [chemical binding]; other site 1133849003726 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 1133849003727 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1133849003728 putative ligand binding site [chemical binding]; other site 1133849003729 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1133849003730 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1133849003731 Walker A/P-loop; other site 1133849003732 ATP binding site [chemical binding]; other site 1133849003733 Q-loop/lid; other site 1133849003734 ABC transporter signature motif; other site 1133849003735 Walker B; other site 1133849003736 D-loop; other site 1133849003737 H-loop/switch region; other site 1133849003738 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1133849003739 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1133849003740 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1133849003741 TM-ABC transporter signature motif; other site 1133849003742 Predicted esterase [General function prediction only]; Region: COG0627 1133849003743 S-formylglutathione hydrolase; Region: PLN02442 1133849003744 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1133849003745 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1133849003746 amidase; Provisional; Region: PRK07869 1133849003747 Amidase; Region: Amidase; cl11426 1133849003748 Predicted membrane protein [Function unknown]; Region: COG1289 1133849003749 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1133849003750 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1133849003751 hydrophobic ligand binding site; other site 1133849003752 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1133849003753 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1133849003754 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849003755 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1133849003756 NAD(P) binding site [chemical binding]; other site 1133849003757 active site 1133849003758 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849003759 Cytochrome P450; Region: p450; cl12078 1133849003760 Predicted transcriptional regulators [Transcription]; Region: COG1733 1133849003761 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1133849003762 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 1133849003763 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849003764 catalytic residue [active] 1133849003765 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 1133849003766 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1133849003767 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1133849003768 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1133849003769 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1133849003770 conserved cys residue [active] 1133849003771 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1133849003772 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849003773 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849003774 SnoaL-like domain; Region: SnoaL_2; pfam12680 1133849003775 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1133849003776 hydrophobic ligand binding site; other site 1133849003777 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849003778 NAD(P) binding site [chemical binding]; other site 1133849003779 active site 1133849003780 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1133849003781 active site 1133849003782 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1133849003783 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849003784 S-adenosylmethionine binding site [chemical binding]; other site 1133849003785 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1133849003786 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1133849003787 glycerol kinase; Provisional; Region: glpK; PRK00047 1133849003788 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 1133849003789 N- and C-terminal domain interface [polypeptide binding]; other site 1133849003790 active site 1133849003791 MgATP binding site [chemical binding]; other site 1133849003792 catalytic site [active] 1133849003793 metal binding site [ion binding]; metal-binding site 1133849003794 putative homotetramer interface [polypeptide binding]; other site 1133849003795 glycerol binding site [chemical binding]; other site 1133849003796 homodimer interface [polypeptide binding]; other site 1133849003797 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1133849003798 amphipathic channel; other site 1133849003799 Asn-Pro-Ala signature motifs; other site 1133849003800 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1133849003801 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1133849003802 Bacterial transcriptional regulator; Region: IclR; pfam01614 1133849003803 glycerol kinase; Provisional; Region: glpK; PRK00047 1133849003804 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 1133849003805 N- and C-terminal domain interface [polypeptide binding]; other site 1133849003806 active site 1133849003807 MgATP binding site [chemical binding]; other site 1133849003808 catalytic site [active] 1133849003809 metal binding site [ion binding]; metal-binding site 1133849003810 putative homotetramer interface [polypeptide binding]; other site 1133849003811 glycerol binding site [chemical binding]; other site 1133849003812 homodimer interface [polypeptide binding]; other site 1133849003813 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1133849003814 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1133849003815 putative di-iron ligands [ion binding]; other site 1133849003816 lipid-transfer protein; Provisional; Region: PRK08256 1133849003817 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1133849003818 active site 1133849003819 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1133849003820 active site 1133849003821 catalytic site [active] 1133849003822 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1133849003823 active site 2 [active] 1133849003824 active site 1 [active] 1133849003825 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1133849003826 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849003827 NAD(P) binding site [chemical binding]; other site 1133849003828 active site 1133849003829 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1133849003830 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849003831 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1133849003832 acyl-activating enzyme (AAE) consensus motif; other site 1133849003833 acyl-activating enzyme (AAE) consensus motif; other site 1133849003834 putative AMP binding site [chemical binding]; other site 1133849003835 putative active site [active] 1133849003836 putative CoA binding site [chemical binding]; other site 1133849003837 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849003838 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849003839 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1133849003840 Protein of unknown function DUF72; Region: DUF72; pfam01904 1133849003841 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 1133849003842 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1133849003843 active site 1133849003844 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1133849003845 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1133849003846 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1133849003847 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1133849003848 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1133849003849 putative metal binding site [ion binding]; other site 1133849003850 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 1133849003851 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1133849003852 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1133849003853 active site 1133849003854 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1133849003855 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849003856 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849003857 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1133849003858 enoyl-CoA hydratase; Provisional; Region: PRK06563 1133849003859 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1133849003860 substrate binding site [chemical binding]; other site 1133849003861 oxyanion hole (OAH) forming residues; other site 1133849003862 trimer interface [polypeptide binding]; other site 1133849003863 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 1133849003864 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1133849003865 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1133849003866 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849003867 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849003868 Cytochrome P450; Region: p450; cl12078 1133849003869 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849003870 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1133849003871 catalytic residue [active] 1133849003872 Peptidases of the G1 family and homologs that might lack peptidase activity; Region: Peptidase_G1_like; cl03371 1133849003873 Peptidases of the G1 family and homologs that might lack peptidase activity; Region: Peptidase_G1_like; cl03371 1133849003874 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 1133849003875 nudix motif; other site 1133849003876 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1133849003877 NlpC/P60 family; Region: NLPC_P60; pfam00877 1133849003878 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1133849003879 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1133849003880 putative metal binding site [ion binding]; other site 1133849003881 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1133849003882 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 1133849003883 putative active site [active] 1133849003884 catalytic triad [active] 1133849003885 putative dimer interface [polypeptide binding]; other site 1133849003886 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1133849003887 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849003888 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1133849003889 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1133849003890 Coenzyme A binding pocket [chemical binding]; other site 1133849003891 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1133849003892 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1133849003893 active site 1133849003894 Zn binding site [ion binding]; other site 1133849003895 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849003896 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849003897 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1133849003898 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1133849003899 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1133849003900 TrkA-C domain; Region: TrkA_C; pfam02080 1133849003901 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 1133849003902 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1133849003903 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1133849003904 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1133849003905 catalytic residue [active] 1133849003906 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 1133849003907 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 1133849003908 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1133849003909 active site 1133849003910 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1133849003911 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1133849003912 active site 1133849003913 active site 1133849003914 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1133849003915 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849003916 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1133849003917 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849003918 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849003919 Walker A/P-loop; other site 1133849003920 ATP binding site [chemical binding]; other site 1133849003921 Q-loop/lid; other site 1133849003922 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1133849003923 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849003924 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1133849003925 Walker A/P-loop; other site 1133849003926 ATP binding site [chemical binding]; other site 1133849003927 Q-loop/lid; other site 1133849003928 ABC transporter signature motif; other site 1133849003929 Walker B; other site 1133849003930 D-loop; other site 1133849003931 H-loop/switch region; other site 1133849003932 Predicted esterase [General function prediction only]; Region: COG0627 1133849003933 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849003934 acyl-activating enzyme (AAE) consensus motif; other site 1133849003935 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849003936 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1133849003937 acyl-activating enzyme (AAE) consensus motif; other site 1133849003938 AMP binding site [chemical binding]; other site 1133849003939 Condensation domain; Region: Condensation; pfam00668 1133849003940 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849003941 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849003942 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849003943 acyl-activating enzyme (AAE) consensus motif; other site 1133849003944 AMP binding site [chemical binding]; other site 1133849003945 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849003946 thioester reductase domain; Region: Thioester-redct; TIGR01746 1133849003947 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1133849003948 putative NAD(P) binding site [chemical binding]; other site 1133849003949 active site 1133849003950 putative substrate binding site [chemical binding]; other site 1133849003951 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1133849003952 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1133849003953 DNA binding residues [nucleotide binding] 1133849003954 dimer interface [polypeptide binding]; other site 1133849003955 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1133849003956 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1133849003957 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849003958 Cytochrome P450; Region: p450; cl12078 1133849003959 UbiA prenyltransferase family; Region: UbiA; pfam01040 1133849003960 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 1133849003961 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1133849003962 substrate binding pocket [chemical binding]; other site 1133849003963 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1133849003964 active site 1133849003965 iron coordination sites [ion binding]; other site 1133849003966 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 1133849003967 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1133849003968 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 1133849003969 active site 1133849003970 metal binding site [ion binding]; metal-binding site 1133849003971 nudix motif; other site 1133849003972 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849003973 putative substrate translocation pore; other site 1133849003974 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849003975 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849003976 DNA binding residues [nucleotide binding] 1133849003977 dimerization interface [polypeptide binding]; other site 1133849003978 DDE superfamily endonuclease; Region: DDE_5; cl17874 1133849003979 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1133849003980 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1133849003981 hypothetical protein; Validated; Region: PRK06840 1133849003982 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1133849003983 dimer interface [polypeptide binding]; other site 1133849003984 active site 1133849003985 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1133849003986 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1133849003987 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1133849003988 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1133849003989 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849003990 NAD(P) binding site [chemical binding]; other site 1133849003991 active site 1133849003992 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1133849003993 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1133849003994 homodimer interface [polypeptide binding]; other site 1133849003995 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1133849003996 active site 1133849003997 TDP-binding site; other site 1133849003998 acceptor substrate-binding pocket; other site 1133849003999 Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673 1133849004000 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1133849004001 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1133849004002 dimer interface [polypeptide binding]; other site 1133849004003 active site 1133849004004 Chain-length factor (CLF) is a factor required for polyketide chain initiation of aromatic antibiotic-producing polyketide synthases (PKSs) of filamentous bacteria. CLFs have been shown to have decarboxylase activity towards malonyl-acyl carrier protein; Region: CLF; cd00832 1133849004005 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1133849004006 active site 1133849004007 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849004008 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849004009 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1133849004010 NAD(P) binding site [chemical binding]; other site 1133849004011 active site 1133849004012 N-terminal and C-terminal aromatase/cyclase domains of Streptomyces rimosus OtcD1 and related domains; Region: OtcD1_ARO-CYC_like; cd08861 1133849004013 putative hydrophobic ligand binding site [chemical binding]; other site 1133849004014 N-terminal and C-terminal aromatase/cyclase domains of Streptomyces rimosus OtcD1 and related domains; Region: OtcD1_ARO-CYC_like; cd08861 1133849004015 putative hydrophobic ligand binding site [chemical binding]; other site 1133849004016 hypothetical protein; Provisional; Region: PRK06834 1133849004017 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1133849004018 hypothetical protein; Provisional; Region: PRK08244 1133849004019 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1133849004020 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1133849004021 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1133849004022 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849004023 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1133849004024 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1133849004025 substrate binding site; other site 1133849004026 tetramer interface; other site 1133849004027 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1133849004028 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1133849004029 inhibitor-cofactor binding pocket; inhibition site 1133849004030 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849004031 catalytic residue [active] 1133849004032 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 1133849004033 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 1133849004034 SnoaL-like domain; Region: SnoaL_4; pfam13577 1133849004035 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1133849004036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849004037 active site 1133849004038 phosphorylation site [posttranslational modification] 1133849004039 intermolecular recognition site; other site 1133849004040 dimerization interface [polypeptide binding]; other site 1133849004041 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1133849004042 DNA binding site [nucleotide binding] 1133849004043 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1133849004044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849004045 active site 1133849004046 phosphorylation site [posttranslational modification] 1133849004047 intermolecular recognition site; other site 1133849004048 dimerization interface [polypeptide binding]; other site 1133849004049 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1133849004050 DNA binding site [nucleotide binding] 1133849004051 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1133849004052 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849004053 NAD(P) binding site [chemical binding]; other site 1133849004054 active site 1133849004055 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1133849004056 FAD binding domain; Region: FAD_binding_4; pfam01565 1133849004057 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1133849004058 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 1133849004059 active site 1133849004060 catalytic site [active] 1133849004061 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1133849004062 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 1133849004063 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 1133849004064 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1133849004065 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1133849004066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849004067 dimer interface [polypeptide binding]; other site 1133849004068 conserved gate region; other site 1133849004069 putative PBP binding loops; other site 1133849004070 ABC-ATPase subunit interface; other site 1133849004071 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1133849004072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849004073 dimer interface [polypeptide binding]; other site 1133849004074 conserved gate region; other site 1133849004075 putative PBP binding loops; other site 1133849004076 ABC-ATPase subunit interface; other site 1133849004077 methyl coenzyme M reductase system, component A2; Region: met_CoM_red_A2; TIGR03269 1133849004078 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1133849004079 Walker A/P-loop; other site 1133849004080 ATP binding site [chemical binding]; other site 1133849004081 Q-loop/lid; other site 1133849004082 ABC transporter signature motif; other site 1133849004083 Walker B; other site 1133849004084 D-loop; other site 1133849004085 H-loop/switch region; other site 1133849004086 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1133849004087 Walker A/P-loop; other site 1133849004088 ATP binding site [chemical binding]; other site 1133849004089 Q-loop/lid; other site 1133849004090 ABC transporter signature motif; other site 1133849004091 Walker B; other site 1133849004092 D-loop; other site 1133849004093 H-loop/switch region; other site 1133849004094 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1133849004095 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1133849004096 DNA binding residues [nucleotide binding] 1133849004097 dimer interface [polypeptide binding]; other site 1133849004098 Beta-lactamase; Region: Beta-lactamase; pfam00144 1133849004099 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1133849004100 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1133849004101 Beta-lactamase; Region: Beta-lactamase; pfam00144 1133849004102 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cd00421 1133849004103 active site 1133849004104 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1133849004105 Predicted acyl esterases [General function prediction only]; Region: COG2936 1133849004106 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1133849004107 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1133849004108 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1133849004109 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1133849004110 putative NAD(P) binding site [chemical binding]; other site 1133849004111 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1133849004112 active site 1133849004113 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1133849004114 ATP binding site [chemical binding]; other site 1133849004115 substrate binding site [chemical binding]; other site 1133849004116 activation loop (A-loop); other site 1133849004117 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1133849004118 SnoaL-like domain; Region: SnoaL_3; pfam13474 1133849004119 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1133849004120 SnoaL-like domain; Region: SnoaL_3; pfam13474 1133849004121 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1133849004122 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849004123 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1133849004124 DNA binding residues [nucleotide binding] 1133849004125 SnoaL-like domain; Region: SnoaL_2; pfam12680 1133849004126 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849004127 sequence-specific DNA binding site [nucleotide binding]; other site 1133849004128 salt bridge; other site 1133849004129 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1133849004130 Secretory lipase; Region: LIP; pfam03583 1133849004131 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849004132 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849004133 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1133849004134 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1133849004135 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1133849004136 oligomer interface [polypeptide binding]; other site 1133849004137 metal binding site [ion binding]; metal-binding site 1133849004138 metal binding site [ion binding]; metal-binding site 1133849004139 putative Cl binding site [ion binding]; other site 1133849004140 basic sphincter; other site 1133849004141 hydrophobic gate; other site 1133849004142 periplasmic entrance; other site 1133849004143 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1133849004144 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1133849004145 substrate binding site [chemical binding]; other site 1133849004146 activation loop (A-loop); other site 1133849004147 amidase; Provisional; Region: PRK06170 1133849004148 Amidase; Region: Amidase; cl11426 1133849004149 flavodoxin; Provisional; Region: PRK06242 1133849004150 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1133849004151 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1133849004152 hypothetical protein; Provisional; Region: PRK07588 1133849004153 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849004154 dimerization interface [polypeptide binding]; other site 1133849004155 putative DNA binding site [nucleotide binding]; other site 1133849004156 SnoaL-like domain; Region: SnoaL_2; pfam12680 1133849004157 MarR family; Region: MarR; pfam01047 1133849004158 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1133849004159 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1133849004160 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1133849004161 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1133849004162 active site 2 [active] 1133849004163 active site 1 [active] 1133849004164 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1133849004165 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1133849004166 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 1133849004167 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 1133849004168 putative NAD(P) binding site [chemical binding]; other site 1133849004169 active site 1133849004170 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1133849004171 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1133849004172 active site 1133849004173 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1133849004174 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1133849004175 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849004176 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849004177 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1133849004178 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1133849004179 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849004180 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1133849004181 Walker A/P-loop; other site 1133849004182 ATP binding site [chemical binding]; other site 1133849004183 Q-loop/lid; other site 1133849004184 ABC transporter signature motif; other site 1133849004185 Walker B; other site 1133849004186 D-loop; other site 1133849004187 H-loop/switch region; other site 1133849004188 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849004189 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1133849004190 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849004191 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1133849004192 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1133849004193 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1133849004194 catalytic triad [active] 1133849004195 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1133849004196 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1133849004197 Pirin-related protein [General function prediction only]; Region: COG1741 1133849004198 Pirin; Region: Pirin; pfam02678 1133849004199 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1133849004200 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1133849004201 MarR family; Region: MarR_2; pfam12802 1133849004202 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 1133849004203 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1133849004204 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1133849004205 catalytic residue [active] 1133849004206 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849004207 S-adenosylmethionine binding site [chemical binding]; other site 1133849004208 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1133849004209 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1133849004210 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1133849004211 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849004212 S-adenosylmethionine binding site [chemical binding]; other site 1133849004213 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849004214 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849004215 Domain of unknown function (DUF385); Region: DUF385; cl04387 1133849004216 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1133849004217 MarR family; Region: MarR; pfam01047 1133849004218 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1133849004219 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 1133849004220 ParB-like nuclease domain; Region: ParB; smart00470 1133849004221 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1133849004222 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1133849004223 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1133849004224 substrate binding pocket [chemical binding]; other site 1133849004225 chain length determination region; other site 1133849004226 substrate-Mg2+ binding site; other site 1133849004227 catalytic residues [active] 1133849004228 aspartate-rich region 1; other site 1133849004229 active site lid residues [active] 1133849004230 aspartate-rich region 2; other site 1133849004231 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1133849004232 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1133849004233 FAD binding pocket [chemical binding]; other site 1133849004234 FAD binding motif [chemical binding]; other site 1133849004235 phosphate binding motif [ion binding]; other site 1133849004236 NAD binding pocket [chemical binding]; other site 1133849004237 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1133849004238 dimer interface [polypeptide binding]; other site 1133849004239 active site 1133849004240 ferredoxin; Provisional; Region: PRK06991 1133849004241 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1133849004242 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1133849004243 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1133849004244 acyl-activating enzyme (AAE) consensus motif; other site 1133849004245 active site 1133849004246 AMP binding site [chemical binding]; other site 1133849004247 substrate binding site [chemical binding]; other site 1133849004248 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1133849004249 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1133849004250 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1133849004251 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1133849004252 active site 1133849004253 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1133849004254 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1133849004255 tetramer interface [polypeptide binding]; other site 1133849004256 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1133849004257 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1133849004258 mevalonate kinase; Region: mevalon_kin; TIGR00549 1133849004259 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 1133849004260 diphosphomevalonate decarboxylase; Region: PLN02407 1133849004261 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 1133849004262 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1133849004263 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1133849004264 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1133849004265 homotetramer interface [polypeptide binding]; other site 1133849004266 FMN binding site [chemical binding]; other site 1133849004267 homodimer contacts [polypeptide binding]; other site 1133849004268 putative active site [active] 1133849004269 putative substrate binding site [chemical binding]; other site 1133849004270 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 1133849004271 homodimer interface [polypeptide binding]; other site 1133849004272 catalytic residues [active] 1133849004273 substrate binding pocket [chemical binding]; other site 1133849004274 NADH/NADPH cofactor binding site [chemical binding]; other site 1133849004275 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1133849004276 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 1133849004277 dimer interface [polypeptide binding]; other site 1133849004278 active site 1133849004279 MMPL family; Region: MMPL; pfam03176 1133849004280 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 1133849004281 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1133849004282 UbiA prenyltransferase family; Region: UbiA; pfam01040 1133849004283 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1133849004284 Isochorismatase family; Region: Isochorismatase; pfam00857 1133849004285 catalytic triad [active] 1133849004286 conserved cis-peptide bond; other site 1133849004287 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1133849004288 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849004289 NAD(P) binding site [chemical binding]; other site 1133849004290 active site 1133849004291 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849004292 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849004293 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1133849004294 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1133849004295 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1133849004296 DNA binding site [nucleotide binding] 1133849004297 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1133849004298 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1133849004299 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1133849004300 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1133849004301 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 1133849004302 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 1133849004303 active site 1133849004304 DNA binding site [nucleotide binding] 1133849004305 catalytic site [active] 1133849004306 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1133849004307 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1133849004308 Coenzyme A binding pocket [chemical binding]; other site 1133849004309 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1133849004310 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1133849004311 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1133849004312 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1133849004313 catalytic site [active] 1133849004314 putative active site [active] 1133849004315 putative substrate binding site [chemical binding]; other site 1133849004316 dimer interface [polypeptide binding]; other site 1133849004317 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1133849004318 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1133849004319 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1133849004320 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1133849004321 catalytic residue [active] 1133849004322 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1133849004323 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1133849004324 active site 1133849004325 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1133849004326 substrate binding site [chemical binding]; other site 1133849004327 catalytic residues [active] 1133849004328 dimer interface [polypeptide binding]; other site 1133849004329 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1133849004330 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849004331 NAD(P) binding site [chemical binding]; other site 1133849004332 active site 1133849004333 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849004334 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1133849004335 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849004336 Predicted transcriptional regulators [Transcription]; Region: COG1695 1133849004337 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1133849004338 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1133849004339 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1133849004340 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1133849004341 active site 1133849004342 FMN binding site [chemical binding]; other site 1133849004343 2,4-decadienoyl-CoA binding site; other site 1133849004344 catalytic residue [active] 1133849004345 4Fe-4S cluster binding site [ion binding]; other site 1133849004346 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1133849004347 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1133849004348 hypothetical protein; Provisional; Region: PRK02237 1133849004349 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1133849004350 active site 1133849004351 dimer interface [polypeptide binding]; other site 1133849004352 motif 1; other site 1133849004353 motif 2; other site 1133849004354 motif 3; other site 1133849004355 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 1133849004356 anticodon binding site; other site 1133849004357 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1133849004358 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1133849004359 active site 1133849004360 metal binding site [ion binding]; metal-binding site 1133849004361 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1133849004362 Alkylmercury lyase; Region: MerB; pfam03243 1133849004363 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849004364 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849004365 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1133849004366 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1133849004367 active site 1133849004368 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1133849004369 DinB superfamily; Region: DinB_2; pfam12867 1133849004370 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849004371 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849004372 SnoaL-like domain; Region: SnoaL_2; pfam12680 1133849004373 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 1133849004374 dimer interface [polypeptide binding]; other site 1133849004375 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849004376 metal binding site [ion binding]; metal-binding site 1133849004377 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1133849004378 Domain of unknown function (DUF385); Region: DUF385; cl04387 1133849004379 SnoaL-like domain; Region: SnoaL_2; pfam12680 1133849004380 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1133849004381 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849004382 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1133849004383 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1133849004384 FAD binding pocket [chemical binding]; other site 1133849004385 FAD binding motif [chemical binding]; other site 1133849004386 phosphate binding motif [ion binding]; other site 1133849004387 beta-alpha-beta structure motif; other site 1133849004388 NAD binding pocket [chemical binding]; other site 1133849004389 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1133849004390 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1133849004391 catalytic loop [active] 1133849004392 iron binding site [ion binding]; other site 1133849004393 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1133849004394 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1133849004395 putative di-iron ligands [ion binding]; other site 1133849004396 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 1133849004397 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849004398 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849004399 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1133849004400 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1133849004401 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1133849004402 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 1133849004403 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849004404 Walker A/P-loop; other site 1133849004405 ATP binding site [chemical binding]; other site 1133849004406 Q-loop/lid; other site 1133849004407 ABC transporter signature motif; other site 1133849004408 Walker B; other site 1133849004409 D-loop; other site 1133849004410 H-loop/switch region; other site 1133849004411 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1133849004412 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1133849004413 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 1133849004414 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 1133849004415 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1133849004416 Na binding site [ion binding]; other site 1133849004417 PAS domain S-box; Region: sensory_box; TIGR00229 1133849004418 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1133849004419 putative active site [active] 1133849004420 heme pocket [chemical binding]; other site 1133849004421 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1133849004422 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1133849004423 metal binding site [ion binding]; metal-binding site 1133849004424 active site 1133849004425 I-site; other site 1133849004426 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1133849004427 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1133849004428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849004429 S-adenosylmethionine binding site [chemical binding]; other site 1133849004430 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1133849004431 PAS fold; Region: PAS_3; pfam08447 1133849004432 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1133849004433 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1133849004434 putative active site [active] 1133849004435 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1133849004436 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1133849004437 active site 1133849004438 catalytic triad [active] 1133849004439 oxyanion hole [active] 1133849004440 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 1133849004441 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1133849004442 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849004443 S-adenosylmethionine binding site [chemical binding]; other site 1133849004444 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1133849004445 putative active site [active] 1133849004446 putative metal binding site [ion binding]; other site 1133849004447 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 1133849004448 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 1133849004449 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1133849004450 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1133849004451 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1133849004452 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1133849004453 metabolite-proton symporter; Region: 2A0106; TIGR00883 1133849004454 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849004455 putative substrate translocation pore; other site 1133849004456 GtrA-like protein; Region: GtrA; pfam04138 1133849004457 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1133849004458 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849004459 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1133849004460 active site 2 [active] 1133849004461 active site 1 [active] 1133849004462 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1133849004463 active site 2 [active] 1133849004464 active site 1 [active] 1133849004465 Helix-turn-helix domain; Region: HTH_38; pfam13936 1133849004466 MarR family; Region: MarR_2; cl17246 1133849004467 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1133849004468 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1133849004469 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1133849004470 dimerization interface [polypeptide binding]; other site 1133849004471 substrate binding pocket [chemical binding]; other site 1133849004472 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849004473 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849004474 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 1133849004475 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849004476 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1133849004477 DNA binding residues [nucleotide binding] 1133849004478 acyltransferase PapA5; Provisional; Region: PRK09294 1133849004479 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1133849004480 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1133849004481 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1133849004482 DNA binding site [nucleotide binding] 1133849004483 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1133849004484 NB-ARC domain; Region: NB-ARC; pfam00931 1133849004485 AAA domain; Region: AAA_14; pfam13173 1133849004486 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849004487 Secretory lipase; Region: LIP; pfam03583 1133849004488 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1133849004489 active site 1133849004490 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1133849004491 catalytic tetrad [active] 1133849004492 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1133849004493 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849004494 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1133849004495 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1133849004496 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1133849004497 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1133849004498 active site 1133849004499 ATP binding site [chemical binding]; other site 1133849004500 substrate binding site [chemical binding]; other site 1133849004501 activation loop (A-loop); other site 1133849004502 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1133849004503 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1133849004504 active site 1133849004505 ATP binding site [chemical binding]; other site 1133849004506 substrate binding site [chemical binding]; other site 1133849004507 activation loop (A-loop); other site 1133849004508 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1133849004509 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1133849004510 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849004511 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1133849004512 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849004513 Secretory lipase; Region: LIP; pfam03583 1133849004514 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1133849004515 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1133849004516 active site 1133849004517 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 1133849004518 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1133849004519 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849004520 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849004521 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1133849004522 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849004523 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1133849004524 active site 1133849004525 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1133849004526 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849004527 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1133849004528 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1133849004529 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 1133849004530 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1133849004531 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1133849004532 substrate binding pocket [chemical binding]; other site 1133849004533 chain length determination region; other site 1133849004534 substrate-Mg2+ binding site; other site 1133849004535 catalytic residues [active] 1133849004536 aspartate-rich region 1; other site 1133849004537 active site lid residues [active] 1133849004538 aspartate-rich region 2; other site 1133849004539 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849004540 Cytochrome P450; Region: p450; cl12078 1133849004541 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1133849004542 substrate binding pocket [chemical binding]; other site 1133849004543 substrate-Mg2+ binding site; other site 1133849004544 aspartate-rich region 1; other site 1133849004545 aspartate-rich region 2; other site 1133849004546 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849004547 Cytochrome P450; Region: p450; cl12078 1133849004548 Copper resistance protein D; Region: CopD; cl00563 1133849004549 Copper resistance protein D; Region: CopD; pfam05425 1133849004550 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1133849004551 threonine dehydratase; Provisional; Region: PRK08246 1133849004552 serine racemase; Region: PLN02970 1133849004553 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849004554 catalytic residue [active] 1133849004555 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1133849004556 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1133849004557 dimer interface [polypeptide binding]; other site 1133849004558 ssDNA binding site [nucleotide binding]; other site 1133849004559 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1133849004560 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 1133849004561 ADP-ribose binding site [chemical binding]; other site 1133849004562 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1133849004563 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849004564 Walker A/P-loop; other site 1133849004565 ATP binding site [chemical binding]; other site 1133849004566 Q-loop/lid; other site 1133849004567 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1133849004568 ABC transporter; Region: ABC_tran_2; pfam12848 1133849004569 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1133849004570 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1133849004571 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1133849004572 active site 1133849004573 AzlC protein; Region: AzlC; cl00570 1133849004574 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1133849004575 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849004576 sequence-specific DNA binding site [nucleotide binding]; other site 1133849004577 salt bridge; other site 1133849004578 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1133849004579 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1133849004580 active site 1133849004581 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1133849004582 apolar tunnel; other site 1133849004583 heme binding site [chemical binding]; other site 1133849004584 dimerization interface [polypeptide binding]; other site 1133849004585 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1133849004586 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1133849004587 active site 1133849004588 catalytic site [active] 1133849004589 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1133849004590 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1133849004591 MarR family; Region: MarR_2; pfam12802 1133849004592 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849004593 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1133849004594 active site 1133849004595 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1133849004596 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1133849004597 active site 1133849004598 ATP binding site [chemical binding]; other site 1133849004599 substrate binding site [chemical binding]; other site 1133849004600 activation loop (A-loop); other site 1133849004601 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 1133849004602 Repair protein; Region: Repair_PSII; pfam04536 1133849004603 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849004604 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1133849004605 NAD(P) binding site [chemical binding]; other site 1133849004606 active site 1133849004607 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1133849004608 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1133849004609 Zn binding site [ion binding]; other site 1133849004610 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1133849004611 ATP binding site [chemical binding]; other site 1133849004612 active site 1133849004613 substrate binding site [chemical binding]; other site 1133849004614 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1133849004615 nudix motif; other site 1133849004616 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1133849004617 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849004618 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1133849004619 YCII-related domain; Region: YCII; cl00999 1133849004620 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1133849004621 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1133849004622 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1133849004623 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1133849004624 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1133849004625 Peptidase family M48; Region: Peptidase_M48; pfam01435 1133849004626 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1133849004627 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1133849004628 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1133849004629 putative DNA binding site [nucleotide binding]; other site 1133849004630 catalytic residue [active] 1133849004631 putative H2TH interface [polypeptide binding]; other site 1133849004632 putative catalytic residues [active] 1133849004633 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1133849004634 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1133849004635 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1133849004636 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1133849004637 metal binding site [ion binding]; metal-binding site 1133849004638 active site 1133849004639 I-site; other site 1133849004640 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 1133849004641 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1133849004642 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849004643 acyltransferase PapA5; Provisional; Region: PRK09294 1133849004644 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849004645 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1133849004646 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849004647 Tetratricopeptide repeat; Region: TPR_10; cl17452 1133849004648 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849004649 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1133849004650 binding surface 1133849004651 TPR motif; other site 1133849004652 TPR repeat; Region: TPR_11; pfam13414 1133849004653 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849004654 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849004655 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849004656 DNA binding residues [nucleotide binding] 1133849004657 dimerization interface [polypeptide binding]; other site 1133849004658 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1133849004659 active site 1133849004660 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 1133849004661 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1133849004662 active site 1133849004663 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1133849004664 short chain dehydrogenase; Provisional; Region: PRK06197 1133849004665 putative NAD(P) binding site [chemical binding]; other site 1133849004666 active site 1133849004667 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1133849004668 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849004669 S-adenosylmethionine binding site [chemical binding]; other site 1133849004670 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849004671 Beta-lactamase; Region: Beta-lactamase; pfam00144 1133849004672 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1133849004673 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 1133849004674 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1133849004675 active site 1133849004676 metal binding site [ion binding]; metal-binding site 1133849004677 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 1133849004678 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849004679 S-adenosylmethionine binding site [chemical binding]; other site 1133849004680 putative phosphoketolase; Provisional; Region: PRK05261 1133849004681 XFP N-terminal domain; Region: XFP_N; pfam09364 1133849004682 XFP C-terminal domain; Region: XFP_C; pfam09363 1133849004683 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1133849004684 trigger factor; Provisional; Region: tig; PRK01490 1133849004685 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1133849004686 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1133849004687 Clp protease; Region: CLP_protease; pfam00574 1133849004688 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1133849004689 oligomer interface [polypeptide binding]; other site 1133849004690 active site residues [active] 1133849004691 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1133849004692 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1133849004693 oligomer interface [polypeptide binding]; other site 1133849004694 active site residues [active] 1133849004695 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1133849004696 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1133849004697 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1133849004698 Walker A motif; other site 1133849004699 ATP binding site [chemical binding]; other site 1133849004700 Walker B motif; other site 1133849004701 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1133849004702 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1133849004703 anti sigma factor interaction site; other site 1133849004704 regulatory phosphorylation site [posttranslational modification]; other site 1133849004705 Ribosomal protein L7/L12 [Translation, ribosomal structure and biogenesis]; Region: RplL; COG0222 1133849004706 L11 interface [polypeptide binding]; other site 1133849004707 putative EF-Tu interaction site [polypeptide binding]; other site 1133849004708 putative EF-G interaction site [polypeptide binding]; other site 1133849004709 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1133849004710 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849004711 putative DNA binding site [nucleotide binding]; other site 1133849004712 putative Zn2+ binding site [ion binding]; other site 1133849004713 AsnC family; Region: AsnC_trans_reg; pfam01037 1133849004714 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1133849004715 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1133849004716 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1133849004717 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1133849004718 active site 1133849004719 catalytic tetrad [active] 1133849004720 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 1133849004721 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1133849004722 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849004723 putative DNA binding site [nucleotide binding]; other site 1133849004724 putative Zn2+ binding site [ion binding]; other site 1133849004725 AsnC family; Region: AsnC_trans_reg; pfam01037 1133849004726 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1133849004727 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 1133849004728 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1133849004729 homodimer interface [polypeptide binding]; other site 1133849004730 substrate-cofactor binding pocket; other site 1133849004731 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849004732 catalytic residue [active] 1133849004733 OsmC-like protein; Region: OsmC; pfam02566 1133849004734 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1133849004735 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1133849004736 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1133849004737 putative molybdopterin cofactor binding site [chemical binding]; other site 1133849004738 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1133849004739 putative molybdopterin cofactor binding site; other site 1133849004740 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1133849004741 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1133849004742 active site 1133849004743 ATP binding site [chemical binding]; other site 1133849004744 substrate binding site [chemical binding]; other site 1133849004745 activation loop (A-loop); other site 1133849004746 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1133849004747 Helix-turn-helix domain; Region: HTH_38; pfam13936 1133849004748 MarR family; Region: MarR_2; pfam12802 1133849004749 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849004750 Cytochrome P450; Region: p450; cl12078 1133849004751 FHA domain; Region: FHA; pfam00498 1133849004752 phosphopeptide binding site; other site 1133849004753 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1133849004754 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849004755 NAD(P) binding site [chemical binding]; other site 1133849004756 active site 1133849004757 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1133849004758 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849004759 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1133849004760 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1133849004761 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1133849004762 Coenzyme A binding pocket [chemical binding]; other site 1133849004763 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1133849004764 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1133849004765 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849004766 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1133849004767 DNA binding residues [nucleotide binding] 1133849004768 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1133849004769 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1133849004770 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849004771 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849004772 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1133849004773 FAD binding domain; Region: FAD_binding_4; pfam01565 1133849004774 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1133849004775 diacylglycerol kinase; Reviewed; Region: PRK11914 1133849004776 AAA domain; Region: AAA_33; pfam13671 1133849004777 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1133849004778 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849004779 non-specific DNA binding site [nucleotide binding]; other site 1133849004780 salt bridge; other site 1133849004781 sequence-specific DNA binding site [nucleotide binding]; other site 1133849004782 Cupin domain; Region: Cupin_2; pfam07883 1133849004783 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1133849004784 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1133849004785 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1133849004786 active site 1133849004787 HIGH motif; other site 1133849004788 nucleotide binding site [chemical binding]; other site 1133849004789 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1133849004790 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1133849004791 active site 1133849004792 KMSKS motif; other site 1133849004793 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1133849004794 tRNA binding surface [nucleotide binding]; other site 1133849004795 anticodon binding site; other site 1133849004796 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1133849004797 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 1133849004798 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1133849004799 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1133849004800 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1133849004801 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1133849004802 active site 1133849004803 multimer interface [polypeptide binding]; other site 1133849004804 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1133849004805 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1133849004806 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1133849004807 homodimer interface [polypeptide binding]; other site 1133849004808 oligonucleotide binding site [chemical binding]; other site 1133849004809 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1133849004810 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1133849004811 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1133849004812 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1133849004813 GTP1/OBG; Region: GTP1_OBG; pfam01018 1133849004814 Obg GTPase; Region: Obg; cd01898 1133849004815 G1 box; other site 1133849004816 GTP/Mg2+ binding site [chemical binding]; other site 1133849004817 Switch I region; other site 1133849004818 G2 box; other site 1133849004819 G3 box; other site 1133849004820 Switch II region; other site 1133849004821 G4 box; other site 1133849004822 G5 box; other site 1133849004823 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1133849004824 gamma-glutamyl kinase; Provisional; Region: PRK05429 1133849004825 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1133849004826 nucleotide binding site [chemical binding]; other site 1133849004827 homotetrameric interface [polypeptide binding]; other site 1133849004828 putative phosphate binding site [ion binding]; other site 1133849004829 putative allosteric binding site; other site 1133849004830 PUA domain; Region: PUA; pfam01472 1133849004831 EspG family; Region: ESX-1_EspG; pfam14011 1133849004832 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1133849004833 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1133849004834 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1133849004835 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849004836 acyl-CoA synthetase; Validated; Region: PRK05850 1133849004837 acyl-activating enzyme (AAE) consensus motif; other site 1133849004838 AMP binding site [chemical binding]; other site 1133849004839 active site 1133849004840 CoA binding site [chemical binding]; other site 1133849004841 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1133849004842 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849004843 NAD(P) binding site [chemical binding]; other site 1133849004844 active site 1133849004845 Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are...; Region: NDPk; cl00335 1133849004846 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 1133849004847 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 1133849004848 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1133849004849 FMN binding site [chemical binding]; other site 1133849004850 dimer interface [polypeptide binding]; other site 1133849004851 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1133849004852 active site 1133849004853 NTP binding site [chemical binding]; other site 1133849004854 metal binding triad [ion binding]; metal-binding site 1133849004855 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 1133849004856 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1133849004857 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1133849004858 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849004859 S-adenosylmethionine binding site [chemical binding]; other site 1133849004860 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849004861 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849004862 O-methyltransferase; Region: Methyltransf_2; pfam00891 1133849004863 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1133849004864 potential frameshift: common BLAST hit: gi|379707917|ref|YP_005263122.1| putative glycosyl transferase 1133849004865 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1133849004866 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1133849004867 DNA binding residues [nucleotide binding] 1133849004868 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1133849004869 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1133849004870 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1133849004871 dinuclear metal binding motif [ion binding]; other site 1133849004872 short chain dehydrogenase; Provisional; Region: PRK05650 1133849004873 classical (c) SDRs; Region: SDR_c; cd05233 1133849004874 NAD(P) binding site [chemical binding]; other site 1133849004875 active site 1133849004876 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1133849004877 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1133849004878 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1133849004879 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 1133849004880 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1133849004881 putative ligand binding site [chemical binding]; other site 1133849004882 putative NAD binding site [chemical binding]; other site 1133849004883 catalytic site [active] 1133849004884 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1133849004885 nucleotide binding site [chemical binding]; other site 1133849004886 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1133849004887 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1133849004888 ATP binding site [chemical binding]; other site 1133849004889 putative Mg++ binding site [ion binding]; other site 1133849004890 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1133849004891 nucleotide binding region [chemical binding]; other site 1133849004892 ATP-binding site [chemical binding]; other site 1133849004893 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1133849004894 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1133849004895 metal binding site [ion binding]; metal-binding site 1133849004896 active site 1133849004897 I-site; other site 1133849004898 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1133849004899 hypothetical protein; Reviewed; Region: PRK09588 1133849004900 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1133849004901 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1133849004902 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1133849004903 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1133849004904 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1133849004905 substrate binding site [chemical binding]; other site 1133849004906 dimer interface [polypeptide binding]; other site 1133849004907 ATP binding site [chemical binding]; other site 1133849004908 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1133849004909 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1133849004910 putative catalytic cysteine [active] 1133849004911 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1133849004912 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1133849004913 Walker A motif; other site 1133849004914 ATP binding site [chemical binding]; other site 1133849004915 Walker B motif; other site 1133849004916 arginine finger; other site 1133849004917 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1133849004918 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1133849004919 metal ion-dependent adhesion site (MIDAS); other site 1133849004920 HSP90 family protein; Provisional; Region: PRK14083 1133849004921 ATP binding site [chemical binding]; other site 1133849004922 Mg2+ binding site [ion binding]; other site 1133849004923 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1133849004924 G-X-G motif; other site 1133849004925 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1133849004926 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1133849004927 active site 1133849004928 (T/H)XGH motif; other site 1133849004929 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1133849004930 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1133849004931 catalytic core [active] 1133849004932 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1133849004933 active site 1133849004934 catalytic triad [active] 1133849004935 oxyanion hole [active] 1133849004936 EDD domain protein, DegV family; Region: DegV; TIGR00762 1133849004937 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1133849004938 SLBB domain; Region: SLBB; pfam10531 1133849004939 comEA protein; Region: comE; TIGR01259 1133849004940 Helix-hairpin-helix motif; Region: HHH; pfam00633 1133849004941 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1133849004942 Competence protein; Region: Competence; pfam03772 1133849004943 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1133849004944 hypothetical protein; Reviewed; Region: PRK07914 1133849004945 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1133849004946 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1133849004947 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1133849004948 active site 1133849004949 catalytic tetrad [active] 1133849004950 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849004951 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1133849004952 non-specific DNA binding site [nucleotide binding]; other site 1133849004953 salt bridge; other site 1133849004954 sequence-specific DNA binding site [nucleotide binding]; other site 1133849004955 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1133849004956 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1133849004957 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1133849004958 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1133849004959 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1133849004960 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1133849004961 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1133849004962 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 1133849004963 amphipathic channel; other site 1133849004964 Asn-Pro-Ala signature motifs; other site 1133849004965 PemK-like protein; Region: PemK; pfam02452 1133849004966 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 1133849004967 Predicted ATPase [General function prediction only]; Region: COG4637 1133849004968 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849004969 Walker A/P-loop; other site 1133849004970 ATP binding site [chemical binding]; other site 1133849004971 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849004972 ABC transporter signature motif; other site 1133849004973 Walker B; other site 1133849004974 D-loop; other site 1133849004975 H-loop/switch region; other site 1133849004976 GTP-binding protein LepA; Provisional; Region: PRK05433 1133849004977 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1133849004978 G1 box; other site 1133849004979 putative GEF interaction site [polypeptide binding]; other site 1133849004980 GTP/Mg2+ binding site [chemical binding]; other site 1133849004981 Switch I region; other site 1133849004982 G2 box; other site 1133849004983 G3 box; other site 1133849004984 Switch II region; other site 1133849004985 G4 box; other site 1133849004986 G5 box; other site 1133849004987 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1133849004988 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1133849004989 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1133849004990 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1133849004991 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1133849004992 dimer interface [polypeptide binding]; other site 1133849004993 phosphorylation site [posttranslational modification] 1133849004994 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849004995 ATP binding site [chemical binding]; other site 1133849004996 Mg2+ binding site [ion binding]; other site 1133849004997 G-X-G motif; other site 1133849004998 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1133849004999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849005000 active site 1133849005001 phosphorylation site [posttranslational modification] 1133849005002 intermolecular recognition site; other site 1133849005003 dimerization interface [polypeptide binding]; other site 1133849005004 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1133849005005 DNA binding site [nucleotide binding] 1133849005006 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1133849005007 Dynamin family; Region: Dynamin_N; pfam00350 1133849005008 G1 box; other site 1133849005009 GTP/Mg2+ binding site [chemical binding]; other site 1133849005010 G2 box; other site 1133849005011 Switch I region; other site 1133849005012 G3 box; other site 1133849005013 Switch II region; other site 1133849005014 G4 box; other site 1133849005015 G5 box; other site 1133849005016 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1133849005017 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1133849005018 Peptidase family M48; Region: Peptidase_M48; pfam01435 1133849005019 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1133849005020 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1133849005021 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1133849005022 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849005023 dimer interface [polypeptide binding]; other site 1133849005024 conserved gate region; other site 1133849005025 putative PBP binding loops; other site 1133849005026 ABC-ATPase subunit interface; other site 1133849005027 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1133849005028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849005029 dimer interface [polypeptide binding]; other site 1133849005030 conserved gate region; other site 1133849005031 putative PBP binding loops; other site 1133849005032 ABC-ATPase subunit interface; other site 1133849005033 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1133849005034 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1133849005035 Walker A/P-loop; other site 1133849005036 ATP binding site [chemical binding]; other site 1133849005037 Q-loop/lid; other site 1133849005038 ABC transporter signature motif; other site 1133849005039 Walker B; other site 1133849005040 D-loop; other site 1133849005041 H-loop/switch region; other site 1133849005042 TOBE domain; Region: TOBE; pfam03459 1133849005043 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1133849005044 nucleotide binding site [chemical binding]; other site 1133849005045 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1133849005046 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 1133849005047 4Fe-4S binding domain; Region: Fer4; pfam00037 1133849005048 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 1133849005049 ferredoxin-NADP+ reductase; Region: PLN02852 1133849005050 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1133849005051 short chain dehydrogenase; Provisional; Region: PRK06172 1133849005052 classical (c) SDRs; Region: SDR_c; cd05233 1133849005053 NAD(P) binding site [chemical binding]; other site 1133849005054 active site 1133849005055 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1133849005056 nucleotide binding site [chemical binding]; other site 1133849005057 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1133849005058 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1133849005059 Putative zinc-finger; Region: zf-HC2; pfam13490 1133849005060 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1133849005061 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 1133849005062 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849005063 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1133849005064 DNA binding residues [nucleotide binding] 1133849005065 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1133849005066 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849005067 active site 1133849005068 Predicted transcriptional regulator [Transcription]; Region: COG2378 1133849005069 WYL domain; Region: WYL; pfam13280 1133849005070 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849005071 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1133849005072 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1133849005073 putative active site [active] 1133849005074 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1133849005075 active site 1133849005076 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 1133849005077 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1133849005078 CysD dimerization site [polypeptide binding]; other site 1133849005079 G1 box; other site 1133849005080 putative GEF interaction site [polypeptide binding]; other site 1133849005081 GTP/Mg2+ binding site [chemical binding]; other site 1133849005082 Switch I region; other site 1133849005083 G2 box; other site 1133849005084 G3 box; other site 1133849005085 Switch II region; other site 1133849005086 G4 box; other site 1133849005087 G5 box; other site 1133849005088 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1133849005089 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1133849005090 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1133849005091 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1133849005092 Active Sites [active] 1133849005093 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1133849005094 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1133849005095 Active Sites [active] 1133849005096 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1133849005097 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1133849005098 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1133849005099 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 1133849005100 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1133849005101 HemN C-terminal domain; Region: HemN_C; pfam06969 1133849005102 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1133849005103 catalytic core [active] 1133849005104 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849005105 non-specific DNA binding site [nucleotide binding]; other site 1133849005106 salt bridge; other site 1133849005107 sequence-specific DNA binding site [nucleotide binding]; other site 1133849005108 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1133849005109 EamA-like transporter family; Region: EamA; pfam00892 1133849005110 EspG family; Region: ESX-1_EspG; pfam14011 1133849005111 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849005112 non-specific DNA binding site [nucleotide binding]; other site 1133849005113 salt bridge; other site 1133849005114 sequence-specific DNA binding site [nucleotide binding]; other site 1133849005115 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 1133849005116 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1133849005117 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 1133849005118 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1133849005119 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1133849005120 chaperone protein DnaJ; Provisional; Region: PRK14278 1133849005121 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1133849005122 HSP70 interaction site [polypeptide binding]; other site 1133849005123 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1133849005124 Zn binding sites [ion binding]; other site 1133849005125 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1133849005126 dimer interface [polypeptide binding]; other site 1133849005127 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1133849005128 RNA methyltransferase, RsmE family; Region: TIGR00046 1133849005129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849005130 putative substrate translocation pore; other site 1133849005131 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1133849005132 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1133849005133 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1133849005134 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1133849005135 putative dimerization interface [polypeptide binding]; other site 1133849005136 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1133849005137 PhoH-like protein; Region: PhoH; pfam02562 1133849005138 metal-binding heat shock protein; Provisional; Region: PRK00016 1133849005139 Domain of unknown function DUF21; Region: DUF21; pfam01595 1133849005140 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1133849005141 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1133849005142 Transporter associated domain; Region: CorC_HlyC; smart01091 1133849005143 GTPase Era; Reviewed; Region: era; PRK00089 1133849005144 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1133849005145 G1 box; other site 1133849005146 GTP/Mg2+ binding site [chemical binding]; other site 1133849005147 Switch I region; other site 1133849005148 G2 box; other site 1133849005149 Switch II region; other site 1133849005150 G3 box; other site 1133849005151 G4 box; other site 1133849005152 G5 box; other site 1133849005153 KH domain; Region: KH_2; pfam07650 1133849005154 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1133849005155 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1133849005156 active site 1133849005157 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 1133849005158 amidase; Provisional; Region: PRK06061 1133849005159 Amidase; Region: Amidase; cl11426 1133849005160 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849005161 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849005162 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849005163 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 1133849005164 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1133849005165 Recombination protein O N terminal; Region: RecO_N; pfam11967 1133849005166 Recombination protein O C terminal; Region: RecO_C; pfam02565 1133849005167 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14829 1133849005168 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1133849005169 catalytic residue [active] 1133849005170 putative FPP diphosphate binding site; other site 1133849005171 putative FPP binding hydrophobic cleft; other site 1133849005172 dimer interface [polypeptide binding]; other site 1133849005173 putative IPP diphosphate binding site; other site 1133849005174 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1133849005175 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1133849005176 Walker A/P-loop; other site 1133849005177 ATP binding site [chemical binding]; other site 1133849005178 Q-loop/lid; other site 1133849005179 ABC transporter signature motif; other site 1133849005180 Walker B; other site 1133849005181 D-loop; other site 1133849005182 H-loop/switch region; other site 1133849005183 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1133849005184 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1133849005185 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1133849005186 Histidine kinase; Region: HisKA_3; pfam07730 1133849005187 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1133849005188 ATP binding site [chemical binding]; other site 1133849005189 Mg2+ binding site [ion binding]; other site 1133849005190 G-X-G motif; other site 1133849005191 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849005192 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849005193 active site 1133849005194 phosphorylation site [posttranslational modification] 1133849005195 intermolecular recognition site; other site 1133849005196 dimerization interface [polypeptide binding]; other site 1133849005197 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 1133849005198 DNA binding residues [nucleotide binding] 1133849005199 YGGT family; Region: YGGT; pfam02325 1133849005200 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849005201 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849005202 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849005203 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849005204 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1133849005205 metal binding site 2 [ion binding]; metal-binding site 1133849005206 putative DNA binding helix; other site 1133849005207 metal binding site 1 [ion binding]; metal-binding site 1133849005208 dimer interface [polypeptide binding]; other site 1133849005209 structural Zn2+ binding site [ion binding]; other site 1133849005210 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849005211 dimerization interface [polypeptide binding]; other site 1133849005212 putative DNA binding site [nucleotide binding]; other site 1133849005213 putative Zn2+ binding site [ion binding]; other site 1133849005214 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1133849005215 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1133849005216 motif 1; other site 1133849005217 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1133849005218 active site 1133849005219 motif 2; other site 1133849005220 motif 3; other site 1133849005221 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1133849005222 anticodon binding site; other site 1133849005223 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1133849005224 2TM domain; Region: 2TM; pfam13239 1133849005225 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1133849005226 acyltransferase PapA5; Provisional; Region: PRK09294 1133849005227 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1133849005228 Moco binding site; other site 1133849005229 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1133849005230 metal coordination site [ion binding]; other site 1133849005231 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1133849005232 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1133849005233 DNA binding residues [nucleotide binding] 1133849005234 drug binding residues [chemical binding]; other site 1133849005235 dimer interface [polypeptide binding]; other site 1133849005236 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1133849005237 Repair protein; Region: Repair_PSII; pfam04536 1133849005238 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1133849005239 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1133849005240 putative active site [active] 1133849005241 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1133849005242 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1133849005243 Zn2+ binding site [ion binding]; other site 1133849005244 Mg2+ binding site [ion binding]; other site 1133849005245 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1133849005246 DNA primase; Validated; Region: dnaG; PRK05667 1133849005247 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1133849005248 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1133849005249 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1133849005250 active site 1133849005251 metal binding site [ion binding]; metal-binding site 1133849005252 interdomain interaction site; other site 1133849005253 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1133849005254 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1133849005255 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1133849005256 putative catalytic site [active] 1133849005257 putative phosphate binding site [ion binding]; other site 1133849005258 putative metal binding site [ion binding]; other site 1133849005259 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1133849005260 Peptidase family M28; Region: Peptidase_M28; pfam04389 1133849005261 metal binding site [ion binding]; metal-binding site 1133849005262 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1133849005263 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1133849005264 Secretory lipase; Region: LIP; pfam03583 1133849005265 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849005266 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849005267 WHG domain; Region: WHG; pfam13305 1133849005268 short chain dehydrogenase; Provisional; Region: PRK06197 1133849005269 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1133849005270 putative NAD(P) binding site [chemical binding]; other site 1133849005271 active site 1133849005272 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849005273 non-specific DNA binding site [nucleotide binding]; other site 1133849005274 salt bridge; other site 1133849005275 sequence-specific DNA binding site [nucleotide binding]; other site 1133849005276 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1133849005277 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1133849005278 motif II; other site 1133849005279 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849005280 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849005281 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1133849005282 Amidase; Region: Amidase; pfam01425 1133849005283 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1133849005284 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1133849005285 putative lipoprotein/autotransporter domain-containing protein; Provisional; Region: PRK14849 1133849005286 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1133849005287 DNA binding site [nucleotide binding] 1133849005288 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1133849005289 Predicted ATPase [General function prediction only]; Region: COG3903 1133849005290 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 1133849005291 Protein of unknown function (DUF1271); Region: DUF1271; pfam06902 1133849005292 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849005293 Cytochrome P450; Region: p450; cl12078 1133849005294 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849005295 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849005296 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1133849005297 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1133849005298 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1133849005299 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1133849005300 Walker A/P-loop; other site 1133849005301 ATP binding site [chemical binding]; other site 1133849005302 Q-loop/lid; other site 1133849005303 ABC transporter signature motif; other site 1133849005304 Walker B; other site 1133849005305 D-loop; other site 1133849005306 H-loop/switch region; other site 1133849005307 FtsI repressor; Provisional; Region: PRK10883 1133849005308 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1133849005309 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1133849005310 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1133849005311 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1133849005312 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1133849005313 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849005314 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1133849005315 DNA binding residues [nucleotide binding] 1133849005316 SnoaL-like domain; Region: SnoaL_2; pfam12680 1133849005317 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1133849005318 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 1133849005319 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1133849005320 active site 1133849005321 DNA binding site [nucleotide binding] 1133849005322 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1133849005323 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1133849005324 active site 1133849005325 HIGH motif; other site 1133849005326 dimer interface [polypeptide binding]; other site 1133849005327 KMSKS motif; other site 1133849005328 S4 RNA-binding domain; Region: S4; smart00363 1133849005329 RNA binding surface [nucleotide binding]; other site 1133849005330 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1133849005331 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1133849005332 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849005333 Walker A/P-loop; other site 1133849005334 ATP binding site [chemical binding]; other site 1133849005335 Q-loop/lid; other site 1133849005336 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1133849005337 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849005338 ABC transporter signature motif; other site 1133849005339 Walker B; other site 1133849005340 D-loop; other site 1133849005341 H-loop/switch region; other site 1133849005342 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849005343 Walker A/P-loop; other site 1133849005344 ATP binding site [chemical binding]; other site 1133849005345 Q-loop/lid; other site 1133849005346 ABC transporter signature motif; other site 1133849005347 Walker B; other site 1133849005348 D-loop; other site 1133849005349 H-loop/switch region; other site 1133849005350 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1133849005351 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1133849005352 substrate binding site [chemical binding]; other site 1133849005353 oxyanion hole (OAH) forming residues; other site 1133849005354 trimer interface [polypeptide binding]; other site 1133849005355 Cupin domain; Region: Cupin_2; cl17218 1133849005356 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1133849005357 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849005358 enoyl-CoA hydratase; Provisional; Region: PRK12478 1133849005359 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1133849005360 substrate binding site [chemical binding]; other site 1133849005361 oxyanion hole (OAH) forming residues; other site 1133849005362 trimer interface [polypeptide binding]; other site 1133849005363 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1133849005364 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849005365 active site 1133849005366 PaaX-like protein; Region: PaaX; pfam07848 1133849005367 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1133849005368 Lsr2; Region: Lsr2; pfam11774 1133849005369 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1133849005370 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1133849005371 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1133849005372 dimerization interface [polypeptide binding]; other site 1133849005373 Lysine efflux permease [General function prediction only]; Region: COG1279 1133849005374 CsbD-like; Region: CsbD; pfam05532 1133849005375 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1133849005376 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1133849005377 Secretory lipase; Region: LIP; pfam03583 1133849005378 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1133849005379 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1133849005380 putative active site [active] 1133849005381 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849005382 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1133849005383 NAD(P) binding site [chemical binding]; other site 1133849005384 active site 1133849005385 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1133849005386 putative active site [active] 1133849005387 putative catalytic site [active] 1133849005388 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1133849005389 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1133849005390 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1133849005391 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1133849005392 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1133849005393 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1133849005394 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1133849005395 FMN-binding pocket [chemical binding]; other site 1133849005396 flavin binding motif; other site 1133849005397 phosphate binding motif [ion binding]; other site 1133849005398 beta-alpha-beta structure motif; other site 1133849005399 NAD binding pocket [chemical binding]; other site 1133849005400 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1133849005401 catalytic loop [active] 1133849005402 iron binding site [ion binding]; other site 1133849005403 short chain dehydrogenase; Validated; Region: PRK05855 1133849005404 classical (c) SDRs; Region: SDR_c; cd05233 1133849005405 NAD(P) binding site [chemical binding]; other site 1133849005406 active site 1133849005407 Uncharacterized conserved protein [Function unknown]; Region: COG4278 1133849005408 Possible enoyl reductase; Region: MDR_enoyl_red; cd08244 1133849005409 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1133849005410 putative NAD(P) binding site [chemical binding]; other site 1133849005411 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1133849005412 Protein of unknown function (DUF3262); Region: DUF3262; cl13160 1133849005413 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849005414 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849005415 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_like_4; cd06152 1133849005416 homotrimer interaction site [polypeptide binding]; other site 1133849005417 putative active site [active] 1133849005418 MarR family; Region: MarR; pfam01047 1133849005419 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849005420 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1133849005421 Walker A/P-loop; other site 1133849005422 ATP binding site [chemical binding]; other site 1133849005423 Q-loop/lid; other site 1133849005424 ABC transporter signature motif; other site 1133849005425 Walker B; other site 1133849005426 D-loop; other site 1133849005427 H-loop/switch region; other site 1133849005428 NB-ARC domain; Region: NB-ARC; pfam00931 1133849005429 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849005430 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1133849005431 binding surface 1133849005432 TPR motif; other site 1133849005433 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849005434 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1133849005435 binding surface 1133849005436 TPR motif; other site 1133849005437 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849005438 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849005439 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1133849005440 binding surface 1133849005441 TPR motif; other site 1133849005442 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849005443 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849005444 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849005445 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849005446 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1133849005447 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1133849005448 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1133849005449 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 1133849005450 choline dehydrogenase; Validated; Region: PRK02106 1133849005451 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1133849005452 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 1133849005453 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1133849005454 catalytic Zn binding site [ion binding]; other site 1133849005455 NAD binding site [chemical binding]; other site 1133849005456 structural Zn binding site [ion binding]; other site 1133849005457 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1133849005458 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849005459 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849005460 Cytochrome P450; Region: p450; cl12078 1133849005461 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1133849005462 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1133849005463 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1133849005464 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1133849005465 DNA binding residues [nucleotide binding] 1133849005466 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1133849005467 Zn binding site [ion binding]; other site 1133849005468 ParB-like nuclease domain; Region: ParB; smart00470 1133849005469 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 1133849005470 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1133849005471 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1133849005472 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1133849005473 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1133849005474 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 1133849005475 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849005476 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1133849005477 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1133849005478 DNA binding residues [nucleotide binding] 1133849005479 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1133849005480 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 1133849005481 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1133849005482 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1133849005483 active site 1133849005484 GAF domain; Region: GAF; pfam01590 1133849005485 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1133849005486 CsbD-like; Region: CsbD; pfam05532 1133849005487 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1133849005488 MarR family; Region: MarR_2; pfam12802 1133849005489 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849005490 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1133849005491 putative substrate translocation pore; other site 1133849005492 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849005493 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1133849005494 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1133849005495 putative metal binding site [ion binding]; other site 1133849005496 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1133849005497 metal ion-dependent adhesion site (MIDAS); other site 1133849005498 Predicted transcriptional regulators [Transcription]; Region: COG1695 1133849005499 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1133849005500 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1133849005501 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1133849005502 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1133849005503 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 1133849005504 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 1133849005505 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849005506 Cytochrome P450; Region: p450; cl12078 1133849005507 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849005508 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849005509 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1133849005510 putative metal binding site [ion binding]; other site 1133849005511 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1133849005512 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1133849005513 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1133849005514 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1133849005515 active site 1133849005516 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1133849005517 aminodeoxychorismate synthase, fungal clade; Region: PabB-fungal; TIGR01823 1133849005518 glutamine binding [chemical binding]; other site 1133849005519 catalytic triad [active] 1133849005520 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1133849005521 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1133849005522 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1133849005523 putative active site [active] 1133849005524 putative substrate binding site [chemical binding]; other site 1133849005525 ATP binding site [chemical binding]; other site 1133849005526 DinB superfamily; Region: DinB_2; pfam12867 1133849005527 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1133849005528 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1133849005529 NAD binding site [chemical binding]; other site 1133849005530 catalytic Zn binding site [ion binding]; other site 1133849005531 substrate binding site [chemical binding]; other site 1133849005532 structural Zn binding site [ion binding]; other site 1133849005533 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1133849005534 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1133849005535 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1133849005536 Beta-lactamase; Region: Beta-lactamase; pfam00144 1133849005537 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1133849005538 Beta-lactamase; Region: Beta-lactamase; pfam00144 1133849005539 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 1133849005540 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 1133849005541 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 1133849005542 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1133849005543 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1133849005544 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1133849005545 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1133849005546 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1133849005547 FAD binding domain; Region: FAD_binding_4; pfam01565 1133849005548 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1133849005549 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1133849005550 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849005551 putative substrate translocation pore; other site 1133849005552 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 1133849005553 homodimer interface [polypeptide binding]; other site 1133849005554 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849005555 catalytic residue [active] 1133849005556 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1133849005557 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1133849005558 Bacterial transcriptional regulator; Region: IclR; pfam01614 1133849005559 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1133849005560 glyoxylate carboligase; Provisional; Region: PRK11269 1133849005561 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1133849005562 PYR/PP interface [polypeptide binding]; other site 1133849005563 dimer interface [polypeptide binding]; other site 1133849005564 TPP binding site [chemical binding]; other site 1133849005565 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1133849005566 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1133849005567 TPP-binding site [chemical binding]; other site 1133849005568 2-hydroxy-3-oxopropionate reductase; Region: tartro_sem_red; TIGR01505 1133849005569 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1133849005570 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 1133849005571 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1133849005572 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1133849005573 Bacterial transcriptional regulator; Region: IclR; pfam01614 1133849005574 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 1133849005575 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1133849005576 HIGH motif; other site 1133849005577 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1133849005578 active site 1133849005579 KMSKS motif; other site 1133849005580 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1133849005581 tRNA binding surface [nucleotide binding]; other site 1133849005582 anticodon binding site; other site 1133849005583 Protein kinase domain; Region: Pkinase; pfam00069 1133849005584 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1133849005585 active site 1133849005586 ATP binding site [chemical binding]; other site 1133849005587 substrate binding site [chemical binding]; other site 1133849005588 activation loop (A-loop); other site 1133849005589 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 1133849005590 active site 1133849005591 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1133849005592 phosphopeptide binding site; other site 1133849005593 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 1133849005594 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1133849005595 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1133849005596 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1133849005597 Walker A motif; other site 1133849005598 ATP binding site [chemical binding]; other site 1133849005599 Walker B motif; other site 1133849005600 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1133849005601 TPR motif; other site 1133849005602 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849005603 binding surface 1133849005604 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 1133849005605 DNA binding residues [nucleotide binding] 1133849005606 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1133849005607 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849005608 Walker A/P-loop; other site 1133849005609 ATP binding site [chemical binding]; other site 1133849005610 Q-loop/lid; other site 1133849005611 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1133849005612 RRP7 domain ribosomal RNA-processing protein 7 (Rrp7p), ribosomal RNA-processing protein 7 homolog A (Rrp7A), and similar proteins; Region: RRP7_like; cl15166 1133849005613 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1133849005614 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1133849005615 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1133849005616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849005617 dimer interface [polypeptide binding]; other site 1133849005618 conserved gate region; other site 1133849005619 ABC-ATPase subunit interface; other site 1133849005620 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1133849005621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849005622 dimer interface [polypeptide binding]; other site 1133849005623 ABC-ATPase subunit interface; other site 1133849005624 putative PBP binding loops; other site 1133849005625 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1133849005626 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849005627 Walker A/P-loop; other site 1133849005628 ATP binding site [chemical binding]; other site 1133849005629 Q-loop/lid; other site 1133849005630 ABC transporter signature motif; other site 1133849005631 Walker B; other site 1133849005632 D-loop; other site 1133849005633 H-loop/switch region; other site 1133849005634 Cytochrome P450; Region: p450; cl12078 1133849005635 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1133849005636 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1133849005637 active site 1133849005638 substrate binding site [chemical binding]; other site 1133849005639 FMN binding site [chemical binding]; other site 1133849005640 putative catalytic residues [active] 1133849005641 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1133849005642 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1133849005643 acyl-CoA synthetase; Validated; Region: PRK06188 1133849005644 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849005645 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849005646 acyl-activating enzyme (AAE) consensus motif; other site 1133849005647 acyl-activating enzyme (AAE) consensus motif; other site 1133849005648 AMP binding site [chemical binding]; other site 1133849005649 active site 1133849005650 CoA binding site [chemical binding]; other site 1133849005651 RibD C-terminal domain; Region: RibD_C; cl17279 1133849005652 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1133849005653 Predicted transcriptional regulator [Transcription]; Region: COG1959 1133849005654 Transcriptional regulator; Region: Rrf2; pfam02082 1133849005655 cyanate transporter; Region: CynX; TIGR00896 1133849005656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849005657 Nitroreductase family; Region: Nitroreductase; pfam00881 1133849005658 FMN binding site [chemical binding]; other site 1133849005659 dimer interface [polypeptide binding]; other site 1133849005660 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849005661 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 1133849005662 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849005663 S-adenosylmethionine binding site [chemical binding]; other site 1133849005664 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1133849005665 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1133849005666 dimer interface [polypeptide binding]; other site 1133849005667 active site 1133849005668 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK06816 1133849005669 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1133849005670 dimer interface [polypeptide binding]; other site 1133849005671 active site 1133849005672 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1133849005673 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1133849005674 active site 1133849005675 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849005676 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1133849005677 NAD(P) binding site [chemical binding]; other site 1133849005678 active site 1133849005679 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1133849005680 phosphate binding site [ion binding]; other site 1133849005681 CGNR zinc finger; Region: zf-CGNR; pfam11706 1133849005682 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1133849005683 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1133849005684 substrate binding site [chemical binding]; other site 1133849005685 oxyanion hole (OAH) forming residues; other site 1133849005686 trimer interface [polypeptide binding]; other site 1133849005687 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1133849005688 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1133849005689 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849005690 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 1133849005691 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1133849005692 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1133849005693 Histidine kinase; Region: HisKA_3; pfam07730 1133849005694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849005695 ATP binding site [chemical binding]; other site 1133849005696 Mg2+ binding site [ion binding]; other site 1133849005697 G-X-G motif; other site 1133849005698 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1133849005699 dimer interface [polypeptide binding]; other site 1133849005700 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1133849005701 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1133849005702 Probable transposase; Region: OrfB_IS605; pfam01385 1133849005703 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 1133849005704 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849005705 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849005706 active site 1133849005707 phosphorylation site [posttranslational modification] 1133849005708 intermolecular recognition site; other site 1133849005709 dimerization interface [polypeptide binding]; other site 1133849005710 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849005711 DNA binding residues [nucleotide binding] 1133849005712 dimerization interface [polypeptide binding]; other site 1133849005713 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1133849005714 Flavodoxin domain; Region: Flavodoxin_5; cl17428 1133849005715 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1133849005716 Transcription factor WhiB; Region: Whib; pfam02467 1133849005717 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1133849005718 putative active site [active] 1133849005719 redox center [active] 1133849005720 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1133849005721 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1133849005722 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849005723 homodimer interface [polypeptide binding]; other site 1133849005724 catalytic residue [active] 1133849005725 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1133849005726 tartrate dehydrogenase; Region: TTC; TIGR02089 1133849005727 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1133849005728 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1133849005729 substrate binding site [chemical binding]; other site 1133849005730 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1133849005731 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1133849005732 substrate binding site [chemical binding]; other site 1133849005733 ligand binding site [chemical binding]; other site 1133849005734 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 1133849005735 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1133849005736 active site 1133849005737 catalytic residues [active] 1133849005738 metal binding site [ion binding]; metal-binding site 1133849005739 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1133849005740 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1133849005741 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1133849005742 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1133849005743 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849005744 C2 domain second repeat in Copine; Region: C2B_Copine; cd04047 1133849005745 putative Ca2+ binding site [ion binding]; other site 1133849005746 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 1133849005747 ornithine cyclodeaminase; Validated; Region: PRK06141 1133849005748 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1133849005749 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1133849005750 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1133849005751 molybdopterin cofactor binding site; other site 1133849005752 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1133849005753 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1133849005754 The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781 1133849005755 putative molybdopterin cofactor binding site; other site 1133849005756 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1133849005757 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1133849005758 FAD binding pocket [chemical binding]; other site 1133849005759 FAD binding motif [chemical binding]; other site 1133849005760 phosphate binding motif [ion binding]; other site 1133849005761 beta-alpha-beta structure motif; other site 1133849005762 NAD binding pocket [chemical binding]; other site 1133849005763 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1133849005764 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1133849005765 catalytic loop [active] 1133849005766 iron binding site [ion binding]; other site 1133849005767 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1133849005768 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1133849005769 DNA-binding site [nucleotide binding]; DNA binding site 1133849005770 FCD domain; Region: FCD; pfam07729 1133849005771 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 1133849005772 homotrimer interaction site [polypeptide binding]; other site 1133849005773 putative active site [active] 1133849005774 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1133849005775 Predicted transcriptional regulators [Transcription]; Region: COG1695 1133849005776 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1133849005777 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1133849005778 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1133849005779 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 1133849005780 Walker A motif; other site 1133849005781 ATP binding site [chemical binding]; other site 1133849005782 Walker B motif; other site 1133849005783 Uncharacterized conserved protein [Function unknown]; Region: COG3410 1133849005784 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 1133849005785 homodimer interface [polypeptide binding]; other site 1133849005786 chemical substrate binding site [chemical binding]; other site 1133849005787 oligomer interface [polypeptide binding]; other site 1133849005788 metal binding site [ion binding]; metal-binding site 1133849005789 Restriction endonuclease; Region: Mrr_cat; pfam04471 1133849005790 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1133849005791 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 1133849005792 dimer interface [polypeptide binding]; other site 1133849005793 catalytic triad [active] 1133849005794 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1133849005795 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1133849005796 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1133849005797 dimer interface [polypeptide binding]; other site 1133849005798 TPP-binding site [chemical binding]; other site 1133849005799 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1133849005800 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1133849005801 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1133849005802 acyl carrier protein; Provisional; Region: acpP; PRK00982 1133849005803 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1133849005804 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1133849005805 dimer interface [polypeptide binding]; other site 1133849005806 active site 1133849005807 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 1133849005808 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1133849005809 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1133849005810 Predicted transcriptional regulators [Transcription]; Region: COG1733 1133849005811 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1133849005812 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 1133849005813 putative FMN binding site [chemical binding]; other site 1133849005814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849005815 S-adenosylmethionine binding site [chemical binding]; other site 1133849005816 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 1133849005817 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 1133849005818 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849005819 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849005820 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849005821 NAD(P) binding site [chemical binding]; other site 1133849005822 active site 1133849005823 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1133849005824 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1133849005825 trimer interface [polypeptide binding]; other site 1133849005826 putative metal binding site [ion binding]; other site 1133849005827 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1133849005828 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1133849005829 conserved cys residue [active] 1133849005830 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1133849005831 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1133849005832 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1133849005833 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1133849005834 hexamer interface [polypeptide binding]; other site 1133849005835 ligand binding site [chemical binding]; other site 1133849005836 putative active site [active] 1133849005837 NAD(P) binding site [chemical binding]; other site 1133849005838 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849005839 Cytochrome P450; Region: p450; cl12078 1133849005840 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1133849005841 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849005842 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1133849005843 DNA binding residues [nucleotide binding] 1133849005844 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1133849005845 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1133849005846 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1133849005847 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1133849005848 active site 1133849005849 hypothetical protein; Provisional; Region: PRK07908 1133849005850 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1133849005851 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849005852 homodimer interface [polypeptide binding]; other site 1133849005853 catalytic residue [active] 1133849005854 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1133849005855 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1133849005856 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1133849005857 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1133849005858 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1133849005859 Putative zinc ribbon domain; Region: DUF164; pfam02591 1133849005860 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1133849005861 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1133849005862 RNA/DNA hybrid binding site [nucleotide binding]; other site 1133849005863 active site 1133849005864 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1133849005865 catalytic core [active] 1133849005866 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849005867 non-specific DNA binding site [nucleotide binding]; other site 1133849005868 salt bridge; other site 1133849005869 sequence-specific DNA binding site [nucleotide binding]; other site 1133849005870 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1133849005871 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1133849005872 Coenzyme A binding pocket [chemical binding]; other site 1133849005873 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1133849005874 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1133849005875 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1133849005876 nudix motif; other site 1133849005877 nudix motif; other site 1133849005878 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849005879 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849005880 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1133849005881 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1133849005882 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849005883 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1133849005884 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1133849005885 RNB domain; Region: RNB; pfam00773 1133849005886 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 1133849005887 CHAD domain; Region: CHAD; pfam05235 1133849005888 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1133849005889 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1133849005890 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1133849005891 TAP-like protein; Region: Abhydrolase_4; pfam08386 1133849005892 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1133849005893 oligomerization interface [polypeptide binding]; other site 1133849005894 active site 1133849005895 metal binding site [ion binding]; metal-binding site 1133849005896 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1133849005897 TAP-like protein; Region: Abhydrolase_4; pfam08386 1133849005898 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1133849005899 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1133849005900 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1133849005901 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1133849005902 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1133849005903 metal binding triad; other site 1133849005904 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1133849005905 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1133849005906 metal binding triad; other site 1133849005907 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1133849005908 Predicted transcriptional regulators [Transcription]; Region: COG1733 1133849005909 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1133849005910 Isochorismatase family; Region: Isochorismatase; pfam00857 1133849005911 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1133849005912 catalytic triad [active] 1133849005913 conserved cis-peptide bond; other site 1133849005914 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1133849005915 putative catalytic site [active] 1133849005916 putative phosphate binding site [ion binding]; other site 1133849005917 putative metal binding site [ion binding]; other site 1133849005918 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1133849005919 lumazine synthase and riboflavin synthase; involved in the riboflavin (vitamin B2) biosynthetic pathway; Region: Lumazine_synthase-like; cl00317 1133849005920 active site 1133849005921 homopentamer interface [polypeptide binding]; other site 1133849005922 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1133849005923 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1133849005924 Serine hydrolase; Region: Ser_hydrolase; cl17834 1133849005925 hypothetical protein; Provisional; Region: PRK08262 1133849005926 M20 Peptidase, carboxypeptidase yscS; Region: M20_yscS; cd05674 1133849005927 metal binding site [ion binding]; metal-binding site 1133849005928 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 1133849005929 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1133849005930 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 1133849005931 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1133849005932 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1133849005933 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 1133849005934 putative active site [active] 1133849005935 putative Zn binding site [ion binding]; other site 1133849005936 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1133849005937 RDD family; Region: RDD; pfam06271 1133849005938 glutamine synthetase, type I; Region: GlnA; TIGR00653 1133849005939 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1133849005940 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1133849005941 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1133849005942 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1133849005943 substrate binding pocket [chemical binding]; other site 1133849005944 catalytic triad [active] 1133849005945 guanine deaminase; Provisional; Region: PRK09228 1133849005946 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 1133849005947 active site 1133849005948 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1133849005949 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1133849005950 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1133849005951 elongation factor G; Reviewed; Region: PRK12740 1133849005952 G1 box; other site 1133849005953 putative GEF interaction site [polypeptide binding]; other site 1133849005954 GTP/Mg2+ binding site [chemical binding]; other site 1133849005955 Switch I region; other site 1133849005956 G2 box; other site 1133849005957 G3 box; other site 1133849005958 Switch II region; other site 1133849005959 G4 box; other site 1133849005960 G5 box; other site 1133849005961 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1133849005962 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1133849005963 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1133849005964 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1133849005965 homotrimer interaction site [polypeptide binding]; other site 1133849005966 putative active site [active] 1133849005967 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1133849005968 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849005969 putative substrate translocation pore; other site 1133849005970 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1133849005971 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1133849005972 Cation efflux family; Region: Cation_efflux; cl00316 1133849005973 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849005974 dimerization interface [polypeptide binding]; other site 1133849005975 putative DNA binding site [nucleotide binding]; other site 1133849005976 putative Zn2+ binding site [ion binding]; other site 1133849005977 lipoyl synthase; Provisional; Region: PRK05481 1133849005978 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1133849005979 FeS/SAM binding site; other site 1133849005980 lipoate-protein ligase B; Provisional; Region: PRK14345 1133849005981 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1133849005982 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1133849005983 Coenzyme A binding pocket [chemical binding]; other site 1133849005984 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849005985 TIGR01777 family protein; Region: yfcH 1133849005986 NAD(P) binding site [chemical binding]; other site 1133849005987 active site 1133849005988 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1133849005989 E3 interaction surface; other site 1133849005990 lipoyl attachment site [posttranslational modification]; other site 1133849005991 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1133849005992 E3 interaction surface; other site 1133849005993 lipoyl attachment site [posttranslational modification]; other site 1133849005994 e3 binding domain; Region: E3_binding; pfam02817 1133849005995 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 1133849005996 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1133849005997 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1133849005998 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1133849005999 interface (dimer of trimers) [polypeptide binding]; other site 1133849006000 Substrate-binding/catalytic site; other site 1133849006001 Zn-binding sites [ion binding]; other site 1133849006002 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849006003 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849006004 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1133849006005 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1133849006006 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1133849006007 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1133849006008 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1133849006009 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1133849006010 homodimer interface [polypeptide binding]; other site 1133849006011 substrate-cofactor binding pocket; other site 1133849006012 catalytic residue [active] 1133849006013 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1133849006014 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1133849006015 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1133849006016 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1133849006017 putative dimer interface [polypeptide binding]; other site 1133849006018 active site pocket [active] 1133849006019 putative cataytic base [active] 1133849006020 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1133849006021 GTP binding site [chemical binding]; other site 1133849006022 Walker B motif; other site 1133849006023 homotrimer interface [polypeptide binding]; other site 1133849006024 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1133849006025 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1133849006026 conserved cys residue [active] 1133849006027 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849006028 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849006029 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1133849006030 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 1133849006031 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 1133849006032 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1133849006033 substrate binding site [chemical binding]; other site 1133849006034 ATP binding site [chemical binding]; other site 1133849006035 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1133849006036 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1133849006037 dimer interface [polypeptide binding]; other site 1133849006038 active site 1133849006039 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1133849006040 Ligand Binding Site [chemical binding]; other site 1133849006041 Molecular Tunnel; other site 1133849006042 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1133849006043 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1133849006044 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1133849006045 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1133849006046 classical (c) SDRs; Region: SDR_c; cd05233 1133849006047 NAD(P) binding site [chemical binding]; other site 1133849006048 active site 1133849006049 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1133849006050 FAD binding domain; Region: FAD_binding_4; pfam01565 1133849006051 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1133849006052 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1133849006053 putative active site [active] 1133849006054 putative metal binding site [ion binding]; other site 1133849006055 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1133849006056 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1133849006057 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1133849006058 putative acyl-acceptor binding pocket; other site 1133849006059 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1133849006060 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1133849006061 nucleotide binding site [chemical binding]; other site 1133849006062 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 1133849006063 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1133849006064 DTAP/Switch II; other site 1133849006065 Switch I; other site 1133849006066 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1133849006067 putative hydrophobic ligand binding site [chemical binding]; other site 1133849006068 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1133849006069 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1133849006070 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1133849006071 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1133849006072 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1133849006073 NlpC/P60 family; Region: NLPC_P60; pfam00877 1133849006074 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1133849006075 NlpC/P60 family; Region: NLPC_P60; pfam00877 1133849006076 hypothetical protein; Validated; Region: PRK07883 1133849006077 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1133849006078 active site 1133849006079 catalytic site [active] 1133849006080 substrate binding site [chemical binding]; other site 1133849006081 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1133849006082 GIY-YIG motif/motif A; other site 1133849006083 active site 1133849006084 catalytic site [active] 1133849006085 putative DNA binding site [nucleotide binding]; other site 1133849006086 metal binding site [ion binding]; metal-binding site 1133849006087 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1133849006088 AsnC family; Region: AsnC_trans_reg; pfam01037 1133849006089 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1133849006090 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1133849006091 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1133849006092 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1133849006093 Subunit I/III interface [polypeptide binding]; other site 1133849006094 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1133849006095 Cytochrome c; Region: Cytochrom_C; pfam00034 1133849006096 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1133849006097 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1133849006098 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1133849006099 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1133849006100 iron-sulfur cluster [ion binding]; other site 1133849006101 [2Fe-2S] cluster binding site [ion binding]; other site 1133849006102 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1133849006103 Qi binding site; other site 1133849006104 intrachain domain interface; other site 1133849006105 interchain domain interface [polypeptide binding]; other site 1133849006106 heme bH binding site [chemical binding]; other site 1133849006107 heme bL binding site [chemical binding]; other site 1133849006108 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1133849006109 Qo binding site; other site 1133849006110 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1133849006111 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1133849006112 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1133849006113 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1133849006114 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1133849006115 active site 1133849006116 ATP binding site [chemical binding]; other site 1133849006117 substrate binding site [chemical binding]; other site 1133849006118 activation loop (A-loop); other site 1133849006119 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1133849006120 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1133849006121 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1133849006122 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1133849006123 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1133849006124 active site lid residues [active] 1133849006125 substrate binding pocket [chemical binding]; other site 1133849006126 catalytic residues [active] 1133849006127 substrate-Mg2+ binding site; other site 1133849006128 aspartate-rich region 1; other site 1133849006129 aspartate-rich region 2; other site 1133849006130 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1133849006131 phytoene desaturase; Region: crtI_fam; TIGR02734 1133849006132 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1133849006133 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1133849006134 substrate binding pocket [chemical binding]; other site 1133849006135 chain length determination region; other site 1133849006136 substrate-Mg2+ binding site; other site 1133849006137 catalytic residues [active] 1133849006138 aspartate-rich region 1; other site 1133849006139 active site lid residues [active] 1133849006140 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1133849006141 aspartate-rich region 2; other site 1133849006142 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1133849006143 FAD binding site [chemical binding]; other site 1133849006144 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1133849006145 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1133849006146 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1133849006147 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1133849006148 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1133849006149 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 1133849006150 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1133849006151 active site 1133849006152 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1133849006153 non-prolyl cis peptide bond; other site 1133849006154 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1133849006155 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1133849006156 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1133849006157 Walker A/P-loop; other site 1133849006158 ATP binding site [chemical binding]; other site 1133849006159 Q-loop/lid; other site 1133849006160 ABC transporter signature motif; other site 1133849006161 Walker B; other site 1133849006162 D-loop; other site 1133849006163 H-loop/switch region; other site 1133849006164 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1133849006165 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1133849006166 Walker A/P-loop; other site 1133849006167 ATP binding site [chemical binding]; other site 1133849006168 Q-loop/lid; other site 1133849006169 ABC transporter signature motif; other site 1133849006170 Walker B; other site 1133849006171 D-loop; other site 1133849006172 H-loop/switch region; other site 1133849006173 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1133849006174 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1133849006175 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849006176 putative PBP binding loops; other site 1133849006177 ABC-ATPase subunit interface; other site 1133849006178 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1133849006179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1133849006180 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849006181 dimer interface [polypeptide binding]; other site 1133849006182 conserved gate region; other site 1133849006183 putative PBP binding loops; other site 1133849006184 ABC-ATPase subunit interface; other site 1133849006185 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 1133849006186 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1133849006187 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1133849006188 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1133849006189 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1133849006190 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1133849006191 substrate binding pocket [chemical binding]; other site 1133849006192 membrane-bound complex binding site; other site 1133849006193 hinge residues; other site 1133849006194 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1133849006195 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1133849006196 Walker A/P-loop; other site 1133849006197 ATP binding site [chemical binding]; other site 1133849006198 Q-loop/lid; other site 1133849006199 ABC transporter signature motif; other site 1133849006200 Walker B; other site 1133849006201 D-loop; other site 1133849006202 H-loop/switch region; other site 1133849006203 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1133849006204 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1133849006205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849006206 dimer interface [polypeptide binding]; other site 1133849006207 conserved gate region; other site 1133849006208 putative PBP binding loops; other site 1133849006209 ABC-ATPase subunit interface; other site 1133849006210 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1133849006211 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1133849006212 active site 1133849006213 Protein of unknown function (DUF422); Region: DUF422; cl00991 1133849006214 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1133849006215 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1133849006216 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1133849006217 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1133849006218 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1133849006219 MraZ protein; Region: MraZ; pfam02381 1133849006220 MraZ protein; Region: MraZ; pfam02381 1133849006221 MraW methylase family; Region: Methyltransf_5; cl17771 1133849006222 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1133849006223 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1133849006224 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1133849006225 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1133849006226 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1133849006227 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1133849006228 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1133849006229 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1133849006230 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1133849006231 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1133849006232 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1133849006233 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1133849006234 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1133849006235 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1133849006236 Mg++ binding site [ion binding]; other site 1133849006237 putative catalytic motif [active] 1133849006238 putative substrate binding site [chemical binding]; other site 1133849006239 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 1133849006240 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1133849006241 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1133849006242 cell division protein FtsW; Region: ftsW; TIGR02614 1133849006243 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1133849006244 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1133849006245 active site 1133849006246 homodimer interface [polypeptide binding]; other site 1133849006247 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1133849006248 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1133849006249 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1133849006250 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1133849006251 cell division protein FtsQ; Provisional; Region: PRK05529 1133849006252 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1133849006253 cell division protein FtsZ; Validated; Region: PRK09330 1133849006254 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1133849006255 nucleotide binding site [chemical binding]; other site 1133849006256 SulA interaction site; other site 1133849006257 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1133849006258 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1133849006259 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1133849006260 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1133849006261 catalytic residue [active] 1133849006262 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1133849006263 YGGT family; Region: YGGT; cl00508 1133849006264 DivIVA domain; Region: DivI1A_domain; TIGR03544 1133849006265 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1133849006266 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1133849006267 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1133849006268 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1133849006269 HIGH motif; other site 1133849006270 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1133849006271 active site 1133849006272 KMSKS motif; other site 1133849006273 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1133849006274 tRNA binding surface [nucleotide binding]; other site 1133849006275 anticodon binding site; other site 1133849006276 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1133849006277 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849006278 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1133849006279 NlpC/P60 family; Region: NLPC_P60; pfam00877 1133849006280 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1133849006281 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1133849006282 active site 1133849006283 tetramer interface; other site 1133849006284 DNA polymerase IV; Provisional; Region: PRK03348 1133849006285 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1133849006286 active site 1133849006287 DNA binding site [nucleotide binding] 1133849006288 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1133849006289 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1133849006290 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1133849006291 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1133849006292 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1133849006293 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1133849006294 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1133849006295 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849006296 dimerization interface [polypeptide binding]; other site 1133849006297 putative DNA binding site [nucleotide binding]; other site 1133849006298 putative Zn2+ binding site [ion binding]; other site 1133849006299 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1133849006300 PGAP1-like protein; Region: PGAP1; pfam07819 1133849006301 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1133849006302 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1133849006303 active site 1133849006304 lipoprotein signal peptidase; Provisional; Region: PRK14764 1133849006305 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1133849006306 putative dimer interface [polypeptide binding]; other site 1133849006307 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1133849006308 iron-sulfur cluster [ion binding]; other site 1133849006309 [2Fe-2S] cluster binding site [ion binding]; other site 1133849006310 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1133849006311 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1133849006312 oligomeric interface; other site 1133849006313 putative active site [active] 1133849006314 homodimer interface [polypeptide binding]; other site 1133849006315 Predicted flavoprotein [General function prediction only]; Region: COG0431 1133849006316 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1133849006317 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849006318 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1133849006319 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1133849006320 Predicted ATPase [General function prediction only]; Region: COG3903 1133849006321 acetyl-CoA synthetase; Provisional; Region: PRK00174 1133849006322 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1133849006323 active site 1133849006324 CoA binding site [chemical binding]; other site 1133849006325 acyl-activating enzyme (AAE) consensus motif; other site 1133849006326 AMP binding site [chemical binding]; other site 1133849006327 acetate binding site [chemical binding]; other site 1133849006328 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1133849006329 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1133849006330 Na binding site [ion binding]; other site 1133849006331 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1133849006332 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1133849006333 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1133849006334 Na binding site [ion binding]; other site 1133849006335 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1133849006336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849006337 active site 1133849006338 phosphorylation site [posttranslational modification] 1133849006339 intermolecular recognition site; other site 1133849006340 dimerization interface [polypeptide binding]; other site 1133849006341 LytTr DNA-binding domain; Region: LytTR; smart00850 1133849006342 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1133849006343 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1133849006344 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1133849006345 active site 1133849006346 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1133849006347 AAA ATPase domain; Region: AAA_16; pfam13191 1133849006348 AAA domain; Region: AAA_22; pfam13401 1133849006349 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849006350 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1133849006351 Histidine kinase; Region: His_kinase; pfam06580 1133849006352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849006353 ATP binding site [chemical binding]; other site 1133849006354 Mg2+ binding site [ion binding]; other site 1133849006355 G-X-G motif; other site 1133849006356 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1133849006357 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1133849006358 active site 1133849006359 PHP Thumb interface [polypeptide binding]; other site 1133849006360 metal binding site [ion binding]; metal-binding site 1133849006361 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1133849006362 generic binding surface II; other site 1133849006363 generic binding surface I; other site 1133849006364 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849006365 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1133849006366 putative substrate translocation pore; other site 1133849006367 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849006368 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849006369 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1133849006370 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1133849006371 Beta-lactamase; Region: Beta-lactamase; pfam00144 1133849006372 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1133849006373 threonine dehydratase; Validated; Region: PRK08639 1133849006374 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1133849006375 tetramer interface [polypeptide binding]; other site 1133849006376 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849006377 catalytic residue [active] 1133849006378 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1133849006379 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1133849006380 AAA ATPase domain; Region: AAA_16; pfam13191 1133849006381 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849006382 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849006383 DNA binding residues [nucleotide binding] 1133849006384 dimerization interface [polypeptide binding]; other site 1133849006385 MspA; Region: MspA; pfam09203 1133849006386 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 1133849006387 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 1133849006388 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1133849006389 active site 1133849006390 catalytic site [active] 1133849006391 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1133849006392 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1133849006393 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1133849006394 active site 1133849006395 catalytic site [active] 1133849006396 Cupin domain; Region: Cupin_2; pfam07883 1133849006397 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1133849006398 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1133849006399 MarR family; Region: MarR_2; cl17246 1133849006400 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1133849006401 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1133849006402 Coenzyme A binding pocket [chemical binding]; other site 1133849006403 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1133849006404 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 1133849006405 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1133849006406 inhibitor-cofactor binding pocket; inhibition site 1133849006407 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849006408 catalytic residue [active] 1133849006409 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1133849006410 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1133849006411 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849006412 catalytic residue [active] 1133849006413 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1133849006414 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1133849006415 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 1133849006416 putative ligand binding residues [chemical binding]; other site 1133849006417 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1133849006418 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1133849006419 Walker A/P-loop; other site 1133849006420 ATP binding site [chemical binding]; other site 1133849006421 Q-loop/lid; other site 1133849006422 ABC transporter signature motif; other site 1133849006423 Walker B; other site 1133849006424 D-loop; other site 1133849006425 H-loop/switch region; other site 1133849006426 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1133849006427 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1133849006428 ABC-ATPase subunit interface; other site 1133849006429 dimer interface [polypeptide binding]; other site 1133849006430 putative PBP binding regions; other site 1133849006431 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849006432 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1133849006433 nucleophilic elbow; other site 1133849006434 catalytic triad; other site 1133849006435 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1133849006436 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1133849006437 substrate binding pocket [chemical binding]; other site 1133849006438 membrane-bound complex binding site; other site 1133849006439 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1133849006440 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849006441 dimer interface [polypeptide binding]; other site 1133849006442 conserved gate region; other site 1133849006443 putative PBP binding loops; other site 1133849006444 ABC-ATPase subunit interface; other site 1133849006445 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1133849006446 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849006447 Walker A/P-loop; other site 1133849006448 ATP binding site [chemical binding]; other site 1133849006449 Q-loop/lid; other site 1133849006450 ABC transporter signature motif; other site 1133849006451 Walker B; other site 1133849006452 D-loop; other site 1133849006453 H-loop/switch region; other site 1133849006454 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1133849006455 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1133849006456 active site 1133849006457 non-prolyl cis peptide bond; other site 1133849006458 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1133849006459 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849006460 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1133849006461 biotin synthase; Validated; Region: PRK06256 1133849006462 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1133849006463 FeS/SAM binding site; other site 1133849006464 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1133849006465 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 1133849006466 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 1133849006467 AAA domain; Region: AAA_33; pfam13671 1133849006468 AAA domain; Region: AAA_17; pfam13207 1133849006469 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1133849006470 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1133849006471 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1133849006472 Beta-lactamase; Region: Beta-lactamase; pfam00144 1133849006473 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1133849006474 Coenzyme A binding pocket [chemical binding]; other site 1133849006475 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1133849006476 catalytic core [active] 1133849006477 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1133849006478 FAD binding domain; Region: FAD_binding_4; pfam01565 1133849006479 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1133849006480 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849006481 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849006482 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1133849006483 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1133849006484 DDE superfamily endonuclease; Region: DDE_5; cl17874 1133849006485 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1133849006486 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1133849006487 ATP binding site [chemical binding]; other site 1133849006488 putative Mg++ binding site [ion binding]; other site 1133849006489 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1133849006490 nucleotide binding region [chemical binding]; other site 1133849006491 ATP-binding site [chemical binding]; other site 1133849006492 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1133849006493 nudix motif; other site 1133849006494 quinolinate synthetase; Provisional; Region: PRK09375 1133849006495 L-aspartate oxidase; Provisional; Region: PRK07804 1133849006496 L-aspartate oxidase; Provisional; Region: PRK06175 1133849006497 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1133849006498 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 1133849006499 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1133849006500 dimerization interface [polypeptide binding]; other site 1133849006501 active site 1133849006502 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1133849006503 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1133849006504 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1133849006505 tellurite resistance protein terB; Region: terB; cd07176 1133849006506 putative metal binding site [ion binding]; other site 1133849006507 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1133849006508 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849006509 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1133849006510 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849006511 NAD(P) binding site [chemical binding]; other site 1133849006512 active site 1133849006513 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1133849006514 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1133849006515 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1133849006516 Predicted membrane protein [Function unknown]; Region: COG4818 1133849006517 Predicted transcriptional regulators [Transcription]; Region: COG1733 1133849006518 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1133849006519 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1133849006520 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1133849006521 dimer interface [polypeptide binding]; other site 1133849006522 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849006523 catalytic residue [active] 1133849006524 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 1133849006525 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1133849006526 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1133849006527 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1133849006528 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1133849006529 active site 1133849006530 ATP binding site [chemical binding]; other site 1133849006531 substrate binding site [chemical binding]; other site 1133849006532 activation loop (A-loop); other site 1133849006533 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 1133849006534 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1133849006535 NAD binding site [chemical binding]; other site 1133849006536 dimerization interface [polypeptide binding]; other site 1133849006537 product binding site; other site 1133849006538 substrate binding site [chemical binding]; other site 1133849006539 zinc binding site [ion binding]; other site 1133849006540 catalytic residues [active] 1133849006541 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1133849006542 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1133849006543 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849006544 homodimer interface [polypeptide binding]; other site 1133849006545 catalytic residue [active] 1133849006546 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1133849006547 putative active site pocket [active] 1133849006548 4-fold oligomerization interface [polypeptide binding]; other site 1133849006549 metal binding residues [ion binding]; metal-binding site 1133849006550 3-fold/trimer interface [polypeptide binding]; other site 1133849006551 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1133849006552 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1133849006553 putative active site [active] 1133849006554 oxyanion strand; other site 1133849006555 catalytic triad [active] 1133849006556 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1133849006557 MarR family; Region: MarR; pfam01047 1133849006558 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1133849006559 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1133849006560 catalytic residues [active] 1133849006561 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1133849006562 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1133849006563 active site 1133849006564 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1133849006565 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1133849006566 substrate binding site [chemical binding]; other site 1133849006567 glutamase interaction surface [polypeptide binding]; other site 1133849006568 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1133849006569 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1133849006570 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1133849006571 MarR family; Region: MarR_2; pfam12802 1133849006572 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1133849006573 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1133849006574 MarR family; Region: MarR_2; cl17246 1133849006575 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1133849006576 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1133849006577 catalytic triad [active] 1133849006578 anthranilate synthase component I; Provisional; Region: PRK13571 1133849006579 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1133849006580 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1133849006581 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 1133849006582 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1133849006583 active site 1133849006584 ribulose/triose binding site [chemical binding]; other site 1133849006585 phosphate binding site [ion binding]; other site 1133849006586 substrate (anthranilate) binding pocket [chemical binding]; other site 1133849006587 product (indole) binding pocket [chemical binding]; other site 1133849006588 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1133849006589 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1133849006590 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849006591 catalytic residue [active] 1133849006592 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1133849006593 substrate binding site [chemical binding]; other site 1133849006594 active site 1133849006595 catalytic residues [active] 1133849006596 heterodimer interface [polypeptide binding]; other site 1133849006597 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1133849006598 TM2 domain; Region: TM2; pfam05154 1133849006599 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1133849006600 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1133849006601 substrate binding pocket [chemical binding]; other site 1133849006602 membrane-bound complex binding site; other site 1133849006603 hinge residues; other site 1133849006604 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1133849006605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849006606 dimer interface [polypeptide binding]; other site 1133849006607 conserved gate region; other site 1133849006608 putative PBP binding loops; other site 1133849006609 ABC-ATPase subunit interface; other site 1133849006610 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1133849006611 pyruvate kinase; Provisional; Region: PRK06247 1133849006612 domain interfaces; other site 1133849006613 active site 1133849006614 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1133849006615 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1133849006616 active site 1133849006617 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1133849006618 catalytic triad [active] 1133849006619 dimer interface [polypeptide binding]; other site 1133849006620 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1133849006621 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1133849006622 active site 1133849006623 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 1133849006624 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1133849006625 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1133849006626 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849006627 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1133849006628 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849006629 dimerization interface [polypeptide binding]; other site 1133849006630 putative DNA binding site [nucleotide binding]; other site 1133849006631 putative Zn2+ binding site [ion binding]; other site 1133849006632 Domain of unknown function (DUF385); Region: DUF385; cl04387 1133849006633 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849006634 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1133849006635 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; cl01548 1133849006636 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1133849006637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849006638 active site 1133849006639 phosphorylation site [posttranslational modification] 1133849006640 intermolecular recognition site; other site 1133849006641 dimerization interface [polypeptide binding]; other site 1133849006642 ANTAR domain; Region: ANTAR; pfam03861 1133849006643 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1133849006644 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1133849006645 dimerization interface [polypeptide binding]; other site 1133849006646 ligand binding site [chemical binding]; other site 1133849006647 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1133849006648 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1133849006649 TM-ABC transporter signature motif; other site 1133849006650 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1133849006651 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1133849006652 TM-ABC transporter signature motif; other site 1133849006653 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1133849006654 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1133849006655 Walker A/P-loop; other site 1133849006656 ATP binding site [chemical binding]; other site 1133849006657 Q-loop/lid; other site 1133849006658 ABC transporter signature motif; other site 1133849006659 Walker B; other site 1133849006660 D-loop; other site 1133849006661 H-loop/switch region; other site 1133849006662 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1133849006663 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1133849006664 Walker A/P-loop; other site 1133849006665 ATP binding site [chemical binding]; other site 1133849006666 Q-loop/lid; other site 1133849006667 ABC transporter signature motif; other site 1133849006668 Walker B; other site 1133849006669 D-loop; other site 1133849006670 H-loop/switch region; other site 1133849006671 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1133849006672 DNA polymerase I; Provisional; Region: PRK05755 1133849006673 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1133849006674 active site 1133849006675 metal binding site 1 [ion binding]; metal-binding site 1133849006676 putative 5' ssDNA interaction site; other site 1133849006677 metal binding site 3; metal-binding site 1133849006678 metal binding site 2 [ion binding]; metal-binding site 1133849006679 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1133849006680 putative DNA binding site [nucleotide binding]; other site 1133849006681 putative metal binding site [ion binding]; other site 1133849006682 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1133849006683 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1133849006684 active site 1133849006685 DNA binding site [nucleotide binding] 1133849006686 catalytic site [active] 1133849006687 Integrase core domain; Region: rve; pfam00665 1133849006688 Integrase core domain; Region: rve_3; pfam13683 1133849006689 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 1133849006690 dimer interface [polypeptide binding]; other site 1133849006691 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849006692 ligand binding site [chemical binding]; other site 1133849006693 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849006694 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849006695 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1133849006696 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1133849006697 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1133849006698 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1133849006699 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1133849006700 FMN binding site [chemical binding]; other site 1133849006701 dimer interface [polypeptide binding]; other site 1133849006702 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849006703 putative transcriptional regulator; Provisional; Region: PRK11640 1133849006704 Cupin domain; Region: Cupin_2; cl17218 1133849006705 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1133849006706 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849006707 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1133849006708 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849006709 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849006710 putative substrate translocation pore; other site 1133849006711 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849006712 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849006713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849006714 H+ Antiporter protein; Region: 2A0121; TIGR00900 1133849006715 putative substrate translocation pore; other site 1133849006716 GTP-binding protein Der; Reviewed; Region: PRK03003 1133849006717 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1133849006718 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1133849006719 Predicted flavoprotein [General function prediction only]; Region: COG0431 1133849006720 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1133849006721 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1133849006722 MarR family; Region: MarR; pfam01047 1133849006723 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1133849006724 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 1133849006725 Protein kinase domain; Region: Pkinase; pfam00069 1133849006726 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1133849006727 active site 1133849006728 ATP binding site [chemical binding]; other site 1133849006729 substrate binding site [chemical binding]; other site 1133849006730 activation loop (A-loop); other site 1133849006731 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1133849006732 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1133849006733 DNA binding residues [nucleotide binding] 1133849006734 dimer interface [polypeptide binding]; other site 1133849006735 Phosphotransferase enzyme family; Region: APH; pfam01636 1133849006736 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1133849006737 active site 1133849006738 substrate binding site [chemical binding]; other site 1133849006739 ATP binding site [chemical binding]; other site 1133849006740 hypothetical protein; Provisional; Region: PRK07236 1133849006741 hypothetical protein; Validated; Region: PRK05868 1133849006742 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849006743 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849006744 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 1133849006745 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1133849006746 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1133849006747 DNA binding residues [nucleotide binding] 1133849006748 dimer interface [polypeptide binding]; other site 1133849006749 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1133849006750 Lipase (class 2); Region: Lipase_2; pfam01674 1133849006751 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1133849006752 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1133849006753 active site clefts [active] 1133849006754 zinc binding site [ion binding]; other site 1133849006755 dimer interface [polypeptide binding]; other site 1133849006756 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1133849006757 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1133849006758 catalytic residues [active] 1133849006759 tartrate dehydrogenase; Provisional; Region: PRK08194 1133849006760 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1133849006761 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1133849006762 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1133849006763 substrate binding pocket [chemical binding]; other site 1133849006764 membrane-bound complex binding site; other site 1133849006765 hinge residues; other site 1133849006766 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1133849006767 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849006768 dimer interface [polypeptide binding]; other site 1133849006769 conserved gate region; other site 1133849006770 putative PBP binding loops; other site 1133849006771 ABC-ATPase subunit interface; other site 1133849006772 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1133849006773 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1133849006774 Walker A/P-loop; other site 1133849006775 ATP binding site [chemical binding]; other site 1133849006776 Q-loop/lid; other site 1133849006777 ABC transporter signature motif; other site 1133849006778 Walker B; other site 1133849006779 D-loop; other site 1133849006780 H-loop/switch region; other site 1133849006781 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1133849006782 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1133849006783 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1133849006784 dimerization interface [polypeptide binding]; other site 1133849006785 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1133849006786 FAD binding domain; Region: FAD_binding_4; pfam01565 1133849006787 Berberine and berberine like; Region: BBE; pfam08031 1133849006788 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 1133849006789 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1133849006790 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 1133849006791 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849006792 S-adenosylmethionine binding site [chemical binding]; other site 1133849006793 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1133849006794 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1133849006795 RNA binding site [nucleotide binding]; other site 1133849006796 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1133849006797 RNA binding site [nucleotide binding]; other site 1133849006798 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1133849006799 RNA binding site [nucleotide binding]; other site 1133849006800 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1133849006801 RNA binding site [nucleotide binding]; other site 1133849006802 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1133849006803 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849006804 MMPL family; Region: MMPL; pfam03176 1133849006805 MMPL family; Region: MMPL; pfam03176 1133849006806 Protein of unknown function (DUF3732); Region: DUF3732; pfam12532 1133849006807 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1133849006808 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1133849006809 NAD binding site [chemical binding]; other site 1133849006810 substrate binding site [chemical binding]; other site 1133849006811 putative active site [active] 1133849006812 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849006813 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849006814 Predicted permeases [General function prediction only]; Region: COG0679 1133849006815 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1133849006816 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1133849006817 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1133849006818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849006819 dimer interface [polypeptide binding]; other site 1133849006820 conserved gate region; other site 1133849006821 putative PBP binding loops; other site 1133849006822 ABC-ATPase subunit interface; other site 1133849006823 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1133849006824 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849006825 dimer interface [polypeptide binding]; other site 1133849006826 conserved gate region; other site 1133849006827 putative PBP binding loops; other site 1133849006828 ABC-ATPase subunit interface; other site 1133849006829 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1133849006830 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1133849006831 Walker A/P-loop; other site 1133849006832 ATP binding site [chemical binding]; other site 1133849006833 Q-loop/lid; other site 1133849006834 ABC transporter signature motif; other site 1133849006835 Walker B; other site 1133849006836 D-loop; other site 1133849006837 H-loop/switch region; other site 1133849006838 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1133849006839 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1133849006840 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1133849006841 Walker A/P-loop; other site 1133849006842 ATP binding site [chemical binding]; other site 1133849006843 Q-loop/lid; other site 1133849006844 ABC transporter signature motif; other site 1133849006845 Walker B; other site 1133849006846 D-loop; other site 1133849006847 H-loop/switch region; other site 1133849006848 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1133849006849 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1133849006850 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842 1133849006851 dimer interface [polypeptide binding]; other site 1133849006852 active site 1133849006853 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1133849006854 catalytic residues [active] 1133849006855 substrate binding site [chemical binding]; other site 1133849006856 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1133849006857 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1133849006858 dimer interface [polypeptide binding]; other site 1133849006859 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849006860 catalytic residue [active] 1133849006861 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1133849006862 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1133849006863 cation binding site [ion binding]; other site 1133849006864 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1133849006865 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1133849006866 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 1133849006867 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1133849006868 CoA-binding site [chemical binding]; other site 1133849006869 ATP-binding [chemical binding]; other site 1133849006870 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1133849006871 Protein of unknown function (DUF402); Region: DUF402; cl00979 1133849006872 Protein of unknown function (DUF402); Region: DUF402; cl00979 1133849006873 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 1133849006874 nudix motif; other site 1133849006875 excinuclease ABC subunit B; Provisional; Region: PRK05298 1133849006876 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1133849006877 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1133849006878 nucleotide binding region [chemical binding]; other site 1133849006879 ATP-binding site [chemical binding]; other site 1133849006880 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1133849006881 UvrB/uvrC motif; Region: UVR; pfam02151 1133849006882 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1133849006883 putative dimer interface [polypeptide binding]; other site 1133849006884 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849006885 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1133849006886 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849006887 Universal stress protein family; Region: Usp; pfam00582 1133849006888 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1133849006889 Part of AAA domain; Region: AAA_19; pfam13245 1133849006890 Family description; Region: UvrD_C_2; pfam13538 1133849006891 PAS domain S-box; Region: sensory_box; TIGR00229 1133849006892 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1133849006893 putative active site [active] 1133849006894 heme pocket [chemical binding]; other site 1133849006895 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1133849006896 PAS domain; Region: PAS_9; pfam13426 1133849006897 putative active site [active] 1133849006898 heme pocket [chemical binding]; other site 1133849006899 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1133849006900 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1133849006901 metal binding site [ion binding]; metal-binding site 1133849006902 active site 1133849006903 I-site; other site 1133849006904 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1133849006905 GAF domain; Region: GAF; pfam01590 1133849006906 GAF domain; Region: GAF; cl17456 1133849006907 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1133849006908 Histidine kinase; Region: HisKA_3; pfam07730 1133849006909 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1133849006910 Histidine kinase; Region: HisKA_3; pfam07730 1133849006911 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849006912 ATP binding site [chemical binding]; other site 1133849006913 Mg2+ binding site [ion binding]; other site 1133849006914 G-X-G motif; other site 1133849006915 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849006916 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849006917 active site 1133849006918 phosphorylation site [posttranslational modification] 1133849006919 intermolecular recognition site; other site 1133849006920 dimerization interface [polypeptide binding]; other site 1133849006921 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849006922 DNA binding residues [nucleotide binding] 1133849006923 dimerization interface [polypeptide binding]; other site 1133849006924 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1133849006925 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1133849006926 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1133849006927 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1133849006928 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 1133849006929 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1133849006930 DNA binding residues [nucleotide binding] 1133849006931 dimer interface [polypeptide binding]; other site 1133849006932 Beta-lactamase; Region: Beta-lactamase; pfam00144 1133849006933 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1133849006934 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1133849006935 Phosphotransferase enzyme family; Region: APH; pfam01636 1133849006936 active site 1133849006937 substrate binding site [chemical binding]; other site 1133849006938 ATP binding site [chemical binding]; other site 1133849006939 CAAX protease self-immunity; Region: Abi; pfam02517 1133849006940 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1133849006941 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 1133849006942 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1133849006943 PA/protease or protease-like domain interface [polypeptide binding]; other site 1133849006944 Peptidase family M28; Region: Peptidase_M28; pfam04389 1133849006945 active site 1133849006946 metal binding site [ion binding]; metal-binding site 1133849006947 Helix-turn-helix domain; Region: HTH_17; pfam12728 1133849006948 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849006949 hypothetical protein; Provisional; Region: PRK06834 1133849006950 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1133849006951 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1133849006952 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849006953 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1133849006954 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1133849006955 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1133849006956 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1133849006957 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1133849006958 23S rRNA binding site [nucleotide binding]; other site 1133849006959 L21 binding site [polypeptide binding]; other site 1133849006960 L13 binding site [polypeptide binding]; other site 1133849006961 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1133849006962 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1133849006963 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1133849006964 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849006965 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849006966 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1133849006967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849006968 putative substrate translocation pore; other site 1133849006969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849006970 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1133849006971 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1133849006972 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1133849006973 dimer interface [polypeptide binding]; other site 1133849006974 motif 1; other site 1133849006975 active site 1133849006976 motif 2; other site 1133849006977 motif 3; other site 1133849006978 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1133849006979 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1133849006980 putative tRNA-binding site [nucleotide binding]; other site 1133849006981 B3/4 domain; Region: B3_4; pfam03483 1133849006982 tRNA synthetase B5 domain; Region: B5; smart00874 1133849006983 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1133849006984 dimer interface [polypeptide binding]; other site 1133849006985 motif 1; other site 1133849006986 motif 3; other site 1133849006987 motif 2; other site 1133849006988 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1133849006989 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1133849006990 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1133849006991 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1133849006992 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1133849006993 Nitrate and nitrite sensing; Region: NIT; pfam08376 1133849006994 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1133849006995 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849006996 ATP binding site [chemical binding]; other site 1133849006997 Mg2+ binding site [ion binding]; other site 1133849006998 G-X-G motif; other site 1133849006999 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 1133849007000 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1133849007001 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1133849007002 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1133849007003 G1 box; other site 1133849007004 GTP/Mg2+ binding site [chemical binding]; other site 1133849007005 G2 box; other site 1133849007006 Switch I region; other site 1133849007007 G3 box; other site 1133849007008 Switch II region; other site 1133849007009 G4 box; other site 1133849007010 G5 box; other site 1133849007011 maltose O-acetyltransferase; Provisional; Region: PRK10092 1133849007012 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1133849007013 active site 1133849007014 substrate binding site [chemical binding]; other site 1133849007015 trimer interface [polypeptide binding]; other site 1133849007016 CoA binding site [chemical binding]; other site 1133849007017 Predicted ATPase [General function prediction only]; Region: COG4637 1133849007018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849007019 Walker A/P-loop; other site 1133849007020 ATP binding site [chemical binding]; other site 1133849007021 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849007022 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1133849007023 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1133849007024 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1133849007025 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1133849007026 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1133849007027 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1133849007028 dimerization interface [polypeptide binding]; other site 1133849007029 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1133849007030 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1133849007031 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1133849007032 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511 1133849007033 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1133849007034 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1133849007035 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1133849007036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849007037 dimer interface [polypeptide binding]; other site 1133849007038 conserved gate region; other site 1133849007039 putative PBP binding loops; other site 1133849007040 ABC-ATPase subunit interface; other site 1133849007041 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1133849007042 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849007043 dimer interface [polypeptide binding]; other site 1133849007044 conserved gate region; other site 1133849007045 putative PBP binding loops; other site 1133849007046 ABC-ATPase subunit interface; other site 1133849007047 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1133849007048 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1133849007049 Walker A/P-loop; other site 1133849007050 ATP binding site [chemical binding]; other site 1133849007051 Q-loop/lid; other site 1133849007052 ABC transporter signature motif; other site 1133849007053 Walker B; other site 1133849007054 D-loop; other site 1133849007055 H-loop/switch region; other site 1133849007056 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1133849007057 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1133849007058 Walker A/P-loop; other site 1133849007059 ATP binding site [chemical binding]; other site 1133849007060 Q-loop/lid; other site 1133849007061 ABC transporter signature motif; other site 1133849007062 Walker B; other site 1133849007063 D-loop; other site 1133849007064 H-loop/switch region; other site 1133849007065 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1133849007066 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1133849007067 homotrimer interaction site [polypeptide binding]; other site 1133849007068 putative active site [active] 1133849007069 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1133849007070 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1133849007071 Bacterial transcriptional regulator; Region: IclR; pfam01614 1133849007072 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1133849007073 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1133849007074 substrate binding site [chemical binding]; other site 1133849007075 ATP binding site [chemical binding]; other site 1133849007076 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1133849007077 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 1133849007078 dimer interface [polypeptide binding]; other site 1133849007079 active site 1133849007080 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1133849007081 substrate binding site [chemical binding]; other site 1133849007082 catalytic residue [active] 1133849007083 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1133849007084 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1133849007085 active site 1133849007086 putative substrate binding pocket [chemical binding]; other site 1133849007087 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1133849007088 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1133849007089 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1133849007090 active site 1133849007091 intersubunit interface [polypeptide binding]; other site 1133849007092 catalytic residue [active] 1133849007093 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1133849007094 GntP family permease; Region: GntP_permease; pfam02447 1133849007095 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849007096 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1133849007097 hypothetical protein; Provisional; Region: PRK06753 1133849007098 HTH domain; Region: HTH_11; pfam08279 1133849007099 WYL domain; Region: WYL; pfam13280 1133849007100 Predicted transcriptional regulator [Transcription]; Region: COG2378 1133849007101 HTH domain; Region: HTH_11; pfam08279 1133849007102 WYL domain; Region: WYL; pfam13280 1133849007103 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1133849007104 Clp amino terminal domain; Region: Clp_N; pfam02861 1133849007105 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1133849007106 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1133849007107 tetramer interface [polypeptide binding]; other site 1133849007108 active site 1133849007109 Mg2+/Mn2+ binding site [ion binding]; other site 1133849007110 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849007111 dimerization interface [polypeptide binding]; other site 1133849007112 putative DNA binding site [nucleotide binding]; other site 1133849007113 putative Zn2+ binding site [ion binding]; other site 1133849007114 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1133849007115 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1133849007116 Secretory lipase; Region: LIP; pfam03583 1133849007117 Secretory lipase; Region: LIP; pfam03583 1133849007118 DoxX-like family; Region: DoxX_2; pfam13564 1133849007119 Predicted transcriptional regulators [Transcription]; Region: COG1733 1133849007120 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1133849007121 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849007122 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849007123 short chain dehydrogenase; Provisional; Region: PRK06500 1133849007124 classical (c) SDRs; Region: SDR_c; cd05233 1133849007125 NAD(P) binding site [chemical binding]; other site 1133849007126 active site 1133849007127 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849007128 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1133849007129 DoxX-like family; Region: DoxX_2; pfam13564 1133849007130 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1133849007131 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849007132 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1133849007133 DNA binding residues [nucleotide binding] 1133849007134 SnoaL-like domain; Region: SnoaL_2; pfam12680 1133849007135 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1133849007136 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 1133849007137 putative NAD(P) binding site [chemical binding]; other site 1133849007138 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1133849007139 Domain of unknown function (DUF4265); Region: DUF4265; pfam14085 1133849007140 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1133849007141 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1133849007142 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1133849007143 NADP binding site [chemical binding]; other site 1133849007144 Predicted transcriptional regulators [Transcription]; Region: COG1733 1133849007145 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1133849007146 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849007147 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849007148 Beta-lactamase; Region: Beta-lactamase; pfam00144 1133849007149 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1133849007150 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1133849007151 hydrophobic ligand binding site; other site 1133849007152 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849007153 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 1133849007154 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1133849007155 putative NAD(P) binding site [chemical binding]; other site 1133849007156 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1133849007157 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1133849007158 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1133849007159 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1133849007160 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849007161 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849007162 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1133849007163 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1133849007164 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849007165 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849007166 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1133849007167 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1133849007168 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1133849007169 heterotetramer interface [polypeptide binding]; other site 1133849007170 active site pocket [active] 1133849007171 cleavage site 1133849007172 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1133849007173 feedback inhibition sensing region; other site 1133849007174 homohexameric interface [polypeptide binding]; other site 1133849007175 nucleotide binding site [chemical binding]; other site 1133849007176 N-acetyl-L-glutamate binding site [chemical binding]; other site 1133849007177 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1133849007178 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1133849007179 inhibitor-cofactor binding pocket; inhibition site 1133849007180 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849007181 catalytic residue [active] 1133849007182 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1133849007183 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1133849007184 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1133849007185 arginine repressor; Provisional; Region: PRK03341 1133849007186 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1133849007187 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1133849007188 argininosuccinate synthase; Provisional; Region: PRK13820 1133849007189 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1133849007190 ANP binding site [chemical binding]; other site 1133849007191 Substrate Binding Site II [chemical binding]; other site 1133849007192 Substrate Binding Site I [chemical binding]; other site 1133849007193 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1133849007194 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1133849007195 argininosuccinate lyase; Provisional; Region: PRK00855 1133849007196 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1133849007197 active sites [active] 1133849007198 tetramer interface [polypeptide binding]; other site 1133849007199 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1133849007200 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849007201 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1133849007202 Walker A/P-loop; other site 1133849007203 ATP binding site [chemical binding]; other site 1133849007204 Q-loop/lid; other site 1133849007205 ABC transporter signature motif; other site 1133849007206 Walker B; other site 1133849007207 D-loop; other site 1133849007208 H-loop/switch region; other site 1133849007209 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1133849007210 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1133849007211 TM-ABC transporter signature motif; other site 1133849007212 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1133849007213 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 1133849007214 putative ligand binding site [chemical binding]; other site 1133849007215 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1133849007216 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 1133849007217 PA/protease or protease-like domain interface [polypeptide binding]; other site 1133849007218 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1133849007219 Peptidase family M28; Region: Peptidase_M28; pfam04389 1133849007220 active site 1133849007221 metal binding site [ion binding]; metal-binding site 1133849007222 threonine dehydratase; Provisional; Region: PRK08198 1133849007223 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1133849007224 tetramer interface [polypeptide binding]; other site 1133849007225 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849007226 catalytic residue [active] 1133849007227 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 1133849007228 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1133849007229 Beta-lactamase; Region: Beta-lactamase; pfam00144 1133849007230 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1133849007231 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1133849007232 DNA-binding site [nucleotide binding]; DNA binding site 1133849007233 FCD domain; Region: FCD; pfam07729 1133849007234 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 1133849007235 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1133849007236 Na binding site [ion binding]; other site 1133849007237 putative substrate binding site [chemical binding]; other site 1133849007238 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1133849007239 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1133849007240 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 1133849007241 nudix motif; other site 1133849007242 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1133849007243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849007244 S-adenosylmethionine binding site [chemical binding]; other site 1133849007245 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1133849007246 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1133849007247 ligand binding site [chemical binding]; other site 1133849007248 flexible hinge region; other site 1133849007249 acyl-CoA synthetase; Validated; Region: PRK07868 1133849007250 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849007251 acyl-activating enzyme (AAE) consensus motif; other site 1133849007252 AMP binding site [chemical binding]; other site 1133849007253 active site 1133849007254 CoA binding site [chemical binding]; other site 1133849007255 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1133849007256 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849007257 S-adenosylmethionine binding site [chemical binding]; other site 1133849007258 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1133849007259 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1133849007260 inhibitor-cofactor binding pocket; inhibition site 1133849007261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849007262 catalytic residue [active] 1133849007263 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1133849007264 active site 1133849007265 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1133849007266 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1133849007267 Predicted membrane protein [Function unknown]; Region: COG2246 1133849007268 GtrA-like protein; Region: GtrA; pfam04138 1133849007269 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1133849007270 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 1133849007271 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1133849007272 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1133849007273 active site 1133849007274 motif I; other site 1133849007275 motif II; other site 1133849007276 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1133849007277 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1133849007278 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1133849007279 RNA binding surface [nucleotide binding]; other site 1133849007280 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1133849007281 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1133849007282 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1133849007283 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1133849007284 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849007285 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1133849007286 ABC transporter signature motif; other site 1133849007287 Walker B; other site 1133849007288 D-loop; other site 1133849007289 H-loop/switch region; other site 1133849007290 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1133849007291 putative hydrophobic ligand binding site [chemical binding]; other site 1133849007292 protein interface [polypeptide binding]; other site 1133849007293 gate; other site 1133849007294 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1133849007295 DNA binding residues [nucleotide binding] 1133849007296 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1133849007297 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1133849007298 Amidase; Region: Amidase; cl11426 1133849007299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849007300 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1133849007301 putative substrate translocation pore; other site 1133849007302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849007303 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849007304 active site 1133849007305 metal binding site [ion binding]; metal-binding site 1133849007306 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase_4; pfam13669 1133849007307 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1133849007308 Peptidase family M23; Region: Peptidase_M23; pfam01551 1133849007309 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 1133849007310 Thiamine pyrophosphokinase; Region: TPK; cl08415 1133849007311 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1133849007312 CTP synthetase; Validated; Region: pyrG; PRK05380 1133849007313 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1133849007314 active site 1133849007315 UTP binding site [chemical binding]; other site 1133849007316 Catalytic site [active] 1133849007317 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1133849007318 active site 1133849007319 putative oxyanion hole; other site 1133849007320 catalytic triad [active] 1133849007321 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1133849007322 dimer interface [polypeptide binding]; other site 1133849007323 active site 1133849007324 ADP-ribose binding site [chemical binding]; other site 1133849007325 nudix motif; other site 1133849007326 metal binding site [ion binding]; metal-binding site 1133849007327 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1133849007328 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1133849007329 active site 1133849007330 DNA binding site [nucleotide binding] 1133849007331 Int/Topo IB signature motif; other site 1133849007332 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1133849007333 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1133849007334 P-loop; other site 1133849007335 Magnesium ion binding site [ion binding]; other site 1133849007336 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1133849007337 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1133849007338 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1133849007339 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1133849007340 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1133849007341 RNA binding surface [nucleotide binding]; other site 1133849007342 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1133849007343 active site 1133849007344 cytidylate kinase; Provisional; Region: cmk; PRK00023 1133849007345 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1133849007346 CMP-binding site; other site 1133849007347 The sites determining sugar specificity; other site 1133849007348 GTP-binding protein Der; Reviewed; Region: PRK03003 1133849007349 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1133849007350 G1 box; other site 1133849007351 GTP/Mg2+ binding site [chemical binding]; other site 1133849007352 Switch I region; other site 1133849007353 G2 box; other site 1133849007354 Switch II region; other site 1133849007355 G3 box; other site 1133849007356 G4 box; other site 1133849007357 G5 box; other site 1133849007358 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1133849007359 G1 box; other site 1133849007360 GTP/Mg2+ binding site [chemical binding]; other site 1133849007361 Switch I region; other site 1133849007362 G2 box; other site 1133849007363 G3 box; other site 1133849007364 Switch II region; other site 1133849007365 G4 box; other site 1133849007366 G5 box; other site 1133849007367 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1133849007368 putative active site [active] 1133849007369 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 1133849007370 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1133849007371 active site 1133849007372 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1133849007373 active site 2 [active] 1133849007374 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1133849007375 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1133849007376 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1133849007377 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1133849007378 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1133849007379 DNA binding residues [nucleotide binding] 1133849007380 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1133849007381 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1133849007382 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1133849007383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1133849007384 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849007385 dimer interface [polypeptide binding]; other site 1133849007386 conserved gate region; other site 1133849007387 putative PBP binding loops; other site 1133849007388 ABC-ATPase subunit interface; other site 1133849007389 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1133849007390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849007391 dimer interface [polypeptide binding]; other site 1133849007392 conserved gate region; other site 1133849007393 putative PBP binding loops; other site 1133849007394 ABC-ATPase subunit interface; other site 1133849007395 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1133849007396 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849007397 Walker A/P-loop; other site 1133849007398 ATP binding site [chemical binding]; other site 1133849007399 Q-loop/lid; other site 1133849007400 ABC transporter signature motif; other site 1133849007401 Walker B; other site 1133849007402 D-loop; other site 1133849007403 H-loop/switch region; other site 1133849007404 TOBE domain; Region: TOBE_2; pfam08402 1133849007405 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1133849007406 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1133849007407 active site 1133849007408 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1133849007409 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1133849007410 Bacterial transcriptional regulator; Region: IclR; pfam01614 1133849007411 CsbD-like; Region: CsbD; pfam05532 1133849007412 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1133849007413 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849007414 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1133849007415 DNA binding residues [nucleotide binding] 1133849007416 Asp23 family; Region: Asp23; cl00574 1133849007417 Asp23 family; Region: Asp23; pfam03780 1133849007418 Asp23 family; Region: Asp23; cl00574 1133849007419 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1133849007420 anti sigma factor interaction site; other site 1133849007421 regulatory phosphorylation site [posttranslational modification]; other site 1133849007422 Response regulator receiver domain; Region: Response_reg; pfam00072 1133849007423 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849007424 active site 1133849007425 phosphorylation site [posttranslational modification] 1133849007426 intermolecular recognition site; other site 1133849007427 dimerization interface [polypeptide binding]; other site 1133849007428 CHASE3 domain; Region: CHASE3; pfam05227 1133849007429 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1133849007430 dimer interface [polypeptide binding]; other site 1133849007431 phosphorylation site [posttranslational modification] 1133849007432 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849007433 ATP binding site [chemical binding]; other site 1133849007434 Mg2+ binding site [ion binding]; other site 1133849007435 G-X-G motif; other site 1133849007436 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1133849007437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849007438 active site 1133849007439 phosphorylation site [posttranslational modification] 1133849007440 intermolecular recognition site; other site 1133849007441 dimerization interface [polypeptide binding]; other site 1133849007442 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1133849007443 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1133849007444 MarR family; Region: MarR; pfam01047 1133849007445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849007446 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1133849007447 putative substrate translocation pore; other site 1133849007448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849007449 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1133849007450 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1133849007451 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1133849007452 YceI-like domain; Region: YceI; smart00867 1133849007453 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849007454 Cytochrome P450; Region: p450; cl12078 1133849007455 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1133849007456 hydrophobic ligand binding site; other site 1133849007457 SnoaL-like domain; Region: SnoaL_2; pfam12680 1133849007458 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1133849007459 Predicted ATPase [General function prediction only]; Region: COG3903 1133849007460 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849007461 S-adenosylmethionine binding site [chemical binding]; other site 1133849007462 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1133849007463 Predicted transcriptional regulators [Transcription]; Region: COG1733 1133849007464 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1133849007465 Predicted transcriptional regulators [Transcription]; Region: COG1733 1133849007466 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1133849007467 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1133849007468 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1133849007469 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 1133849007470 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1133849007471 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1133849007472 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1133849007473 dimer interface [polypeptide binding]; other site 1133849007474 active site 1133849007475 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849007476 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1133849007477 acyl-activating enzyme (AAE) consensus motif; other site 1133849007478 AMP binding site [chemical binding]; other site 1133849007479 active site 1133849007480 CoA binding site [chemical binding]; other site 1133849007481 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 1133849007482 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1133849007483 active site 1133849007484 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1133849007485 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1133849007486 DNA binding residues [nucleotide binding] 1133849007487 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1133849007488 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1133849007489 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1133849007490 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1133849007491 Secretory lipase; Region: LIP; pfam03583 1133849007492 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1133849007493 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1133849007494 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1133849007495 benzoate transport; Region: 2A0115; TIGR00895 1133849007496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849007497 putative substrate translocation pore; other site 1133849007498 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1133849007499 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1133849007500 DNA-binding site [nucleotide binding]; DNA binding site 1133849007501 FCD domain; Region: FCD; pfam07729 1133849007502 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849007503 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849007504 DNA binding residues [nucleotide binding] 1133849007505 dimerization interface [polypeptide binding]; other site 1133849007506 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1133849007507 FAD binding domain; Region: FAD_binding_4; pfam01565 1133849007508 Berberine and berberine like; Region: BBE; pfam08031 1133849007509 PaaX-like protein; Region: PaaX; pfam07848 1133849007510 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 1133849007511 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1133849007512 kynureninase; Region: kynureninase; TIGR01814 1133849007513 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1133849007514 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849007515 catalytic residue [active] 1133849007516 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 1133849007517 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1133849007518 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1133849007519 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849007520 NAD(P) binding site [chemical binding]; other site 1133849007521 active site 1133849007522 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1133849007523 active site 1133849007524 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1133849007525 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1133849007526 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1133849007527 classical (c) SDRs; Region: SDR_c; cd05233 1133849007528 NAD(P) binding site [chemical binding]; other site 1133849007529 active site 1133849007530 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1133849007531 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1133849007532 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1133849007533 NAD(P) binding site [chemical binding]; other site 1133849007534 catalytic residues [active] 1133849007535 Protein of unknown function (DUF779); Region: DUF779; pfam05610 1133849007536 FixH; Region: FixH; pfam05751 1133849007537 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849007538 ATP binding site [chemical binding]; other site 1133849007539 Mg2+ binding site [ion binding]; other site 1133849007540 G-X-G motif; other site 1133849007541 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849007542 Cytochrome P450; Region: p450; cl12078 1133849007543 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1133849007544 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1133849007545 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1133849007546 Beta-lactamase; Region: Beta-lactamase; pfam00144 1133849007547 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 1133849007548 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1133849007549 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1133849007550 substrate binding pocket [chemical binding]; other site 1133849007551 chain length determination region; other site 1133849007552 substrate-Mg2+ binding site; other site 1133849007553 catalytic residues [active] 1133849007554 aspartate-rich region 1; other site 1133849007555 active site lid residues [active] 1133849007556 aspartate-rich region 2; other site 1133849007557 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1133849007558 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1133849007559 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1133849007560 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1133849007561 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1133849007562 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1133849007563 substrate binding pocket [chemical binding]; other site 1133849007564 substrate-Mg2+ binding site; other site 1133849007565 aspartate-rich region 1; other site 1133849007566 aspartate-rich region 2; other site 1133849007567 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1133849007568 substrate binding pocket [chemical binding]; other site 1133849007569 substrate-Mg2+ binding site; other site 1133849007570 aspartate-rich region 1; other site 1133849007571 aspartate-rich region 2; other site 1133849007572 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1133849007573 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1133849007574 substrate binding pocket [chemical binding]; other site 1133849007575 chain length determination region; other site 1133849007576 substrate-Mg2+ binding site; other site 1133849007577 catalytic residues [active] 1133849007578 aspartate-rich region 1; other site 1133849007579 active site lid residues [active] 1133849007580 aspartate-rich region 2; other site 1133849007581 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1133849007582 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1133849007583 ligand binding site [chemical binding]; other site 1133849007584 flexible hinge region; other site 1133849007585 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1133849007586 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 1133849007587 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1133849007588 inhibitor-cofactor binding pocket; inhibition site 1133849007589 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849007590 catalytic residue [active] 1133849007591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849007592 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1133849007593 putative substrate translocation pore; other site 1133849007594 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1133849007595 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1133849007596 substrate-cofactor binding pocket; other site 1133849007597 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849007598 catalytic residue [active] 1133849007599 acetolactate synthase catalytic subunit; Validated; Region: PRK06112 1133849007600 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1133849007601 PYR/PP interface [polypeptide binding]; other site 1133849007602 dimer interface [polypeptide binding]; other site 1133849007603 TPP binding site [chemical binding]; other site 1133849007604 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1133849007605 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1133849007606 TPP-binding site [chemical binding]; other site 1133849007607 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1133849007608 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1133849007609 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1133849007610 dimerization interface [polypeptide binding]; other site 1133849007611 substrate binding pocket [chemical binding]; other site 1133849007612 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1133849007613 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849007614 non-specific DNA binding site [nucleotide binding]; other site 1133849007615 salt bridge; other site 1133849007616 sequence-specific DNA binding site [nucleotide binding]; other site 1133849007617 Cupin domain; Region: Cupin_2; pfam07883 1133849007618 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1133849007619 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849007620 putative substrate translocation pore; other site 1133849007621 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1133849007622 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1133849007623 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1133849007624 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 1133849007625 BioY family; Region: BioY; pfam02632 1133849007626 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849007627 acyl-activating enzyme (AAE) consensus motif; other site 1133849007628 AMP binding site [chemical binding]; other site 1133849007629 active site 1133849007630 CoA binding site [chemical binding]; other site 1133849007631 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1133849007632 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1133849007633 dimer interface [polypeptide binding]; other site 1133849007634 active site 1133849007635 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1133849007636 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1133849007637 Walker A/P-loop; other site 1133849007638 ATP binding site [chemical binding]; other site 1133849007639 Q-loop/lid; other site 1133849007640 ABC transporter signature motif; other site 1133849007641 Walker B; other site 1133849007642 D-loop; other site 1133849007643 H-loop/switch region; other site 1133849007644 Cobalt transport protein; Region: CbiQ; cl00463 1133849007645 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849007646 acyl-CoA synthetase; Validated; Region: PRK07638 1133849007647 acyl-activating enzyme (AAE) consensus motif; other site 1133849007648 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849007649 AMP binding site [chemical binding]; other site 1133849007650 active site 1133849007651 acyl-activating enzyme (AAE) consensus motif; other site 1133849007652 CoA binding site [chemical binding]; other site 1133849007653 Helix-turn-helix domain; Region: HTH_18; pfam12833 1133849007654 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1133849007655 active site 1133849007656 catalytic site [active] 1133849007657 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1133849007658 active site 2 [active] 1133849007659 active site 1 [active] 1133849007660 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1133849007661 Zn binding site [ion binding]; other site 1133849007662 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 1133849007663 arginine-tRNA ligase; Region: PLN02286 1133849007664 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1133849007665 active site 1133849007666 HIGH motif; other site 1133849007667 nucleotide binding site [chemical binding]; other site 1133849007668 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1133849007669 KMSK motif region; other site 1133849007670 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1133849007671 tRNA binding surface [nucleotide binding]; other site 1133849007672 anticodon binding site; other site 1133849007673 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1133849007674 Cutinase; Region: Cutinase; pfam01083 1133849007675 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1133849007676 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1133849007677 DNA-binding site [nucleotide binding]; DNA binding site 1133849007678 FCD domain; Region: FCD; pfam07729 1133849007679 amino acid transporter; Region: 2A0306; TIGR00909 1133849007680 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1133849007681 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1133849007682 Proline racemase; Region: Pro_racemase; pfam05544 1133849007683 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1133849007684 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1133849007685 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1133849007686 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1133849007687 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1133849007688 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1133849007689 dimer interface [polypeptide binding]; other site 1133849007690 NADP binding site [chemical binding]; other site 1133849007691 catalytic residues [active] 1133849007692 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1133849007693 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1133849007694 inhibitor site; inhibition site 1133849007695 active site 1133849007696 dimer interface [polypeptide binding]; other site 1133849007697 catalytic residue [active] 1133849007698 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1133849007699 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 1133849007700 NAD(P) binding site [chemical binding]; other site 1133849007701 catalytic residues [active] 1133849007702 acyl-CoA synthetase; Validated; Region: PRK05850 1133849007703 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1133849007704 acyl-activating enzyme (AAE) consensus motif; other site 1133849007705 active site 1133849007706 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1133849007707 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 1133849007708 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1133849007709 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1133849007710 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1133849007711 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849007712 catalytic residue [active] 1133849007713 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1133849007714 substrate binding pocket [chemical binding]; other site 1133849007715 substrate-Mg2+ binding site; other site 1133849007716 aspartate-rich region 1; other site 1133849007717 aspartate-rich region 2; other site 1133849007718 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849007719 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1133849007720 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 1133849007721 active site 1133849007722 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 1133849007723 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1133849007724 putative active site [active] 1133849007725 putative FMN binding site [chemical binding]; other site 1133849007726 putative substrate binding site [chemical binding]; other site 1133849007727 putative catalytic residue [active] 1133849007728 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849007729 MMPL family; Region: MMPL; pfam03176 1133849007730 MMPL family; Region: MMPL; pfam03176 1133849007731 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683 1133849007732 nudix motif; other site 1133849007733 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1133849007734 putative active site [active] 1133849007735 putative CoA binding site [chemical binding]; other site 1133849007736 nudix motif; other site 1133849007737 metal binding site [ion binding]; metal-binding site 1133849007738 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1133849007739 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1133849007740 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1133849007741 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1133849007742 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1133849007743 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1133849007744 NAD binding site [chemical binding]; other site 1133849007745 sugar binding site [chemical binding]; other site 1133849007746 divalent metal binding site [ion binding]; other site 1133849007747 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1133849007748 dimer interface [polypeptide binding]; other site 1133849007749 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1133849007750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849007751 dimer interface [polypeptide binding]; other site 1133849007752 conserved gate region; other site 1133849007753 putative PBP binding loops; other site 1133849007754 ABC-ATPase subunit interface; other site 1133849007755 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1133849007756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849007757 dimer interface [polypeptide binding]; other site 1133849007758 conserved gate region; other site 1133849007759 putative PBP binding loops; other site 1133849007760 ABC-ATPase subunit interface; other site 1133849007761 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1133849007762 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1133849007763 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1133849007764 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1133849007765 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1133849007766 nucleotide binding site [chemical binding]; other site 1133849007767 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 1133849007768 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1133849007769 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1133849007770 active site 1133849007771 metal binding site [ion binding]; metal-binding site 1133849007772 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1133849007773 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1133849007774 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1133849007775 dimer interface [polypeptide binding]; other site 1133849007776 active site 1133849007777 heme binding site [chemical binding]; other site 1133849007778 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1133849007779 SelR domain; Region: SelR; pfam01641 1133849007780 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1133849007781 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1133849007782 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1133849007783 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1133849007784 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849007785 putative DNA binding site [nucleotide binding]; other site 1133849007786 dimerization interface [polypeptide binding]; other site 1133849007787 putative Zn2+ binding site [ion binding]; other site 1133849007788 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 1133849007789 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1133849007790 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1133849007791 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1133849007792 CGNR zinc finger; Region: zf-CGNR; pfam11706 1133849007793 YaeQ protein; Region: YaeQ; pfam07152 1133849007794 hypothetical protein; Provisional; Region: PRK09133 1133849007795 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1133849007796 putative metal binding site [ion binding]; other site 1133849007797 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849007798 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1133849007799 Walker A/P-loop; other site 1133849007800 ATP binding site [chemical binding]; other site 1133849007801 Q-loop/lid; other site 1133849007802 ABC transporter signature motif; other site 1133849007803 Walker B; other site 1133849007804 D-loop; other site 1133849007805 H-loop/switch region; other site 1133849007806 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1133849007807 active site 1133849007808 zinc binding site [ion binding]; other site 1133849007809 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1133849007810 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 1133849007811 active site 1133849007812 zinc binding site [ion binding]; other site 1133849007813 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 1133849007814 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 1133849007815 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 1133849007816 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849007817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849007818 active site 1133849007819 phosphorylation site [posttranslational modification] 1133849007820 intermolecular recognition site; other site 1133849007821 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849007822 DNA binding residues [nucleotide binding] 1133849007823 dimerization interface [polypeptide binding]; other site 1133849007824 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1133849007825 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1133849007826 active site 1133849007827 PHP Thumb interface [polypeptide binding]; other site 1133849007828 metal binding site [ion binding]; metal-binding site 1133849007829 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1133849007830 generic binding surface II; other site 1133849007831 generic binding surface I; other site 1133849007832 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1133849007833 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1133849007834 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1133849007835 dimerization interface [polypeptide binding]; other site 1133849007836 enoyl-CoA hydratase; Validated; Region: PRK08139 1133849007837 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1133849007838 substrate binding site [chemical binding]; other site 1133849007839 oxyanion hole (OAH) forming residues; other site 1133849007840 trimer interface [polypeptide binding]; other site 1133849007841 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1133849007842 catalytic triad [active] 1133849007843 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1133849007844 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1133849007845 DNA binding residues [nucleotide binding] 1133849007846 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1133849007847 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1133849007848 DNA binding residues [nucleotide binding] 1133849007849 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1133849007850 HTH-like domain; Region: HTH_21; pfam13276 1133849007851 Integrase core domain; Region: rve; pfam00665 1133849007852 Integrase core domain; Region: rve_3; pfam13683 1133849007853 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1133849007854 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1133849007855 DNA-binding site [nucleotide binding]; DNA binding site 1133849007856 FCD domain; Region: FCD; pfam07729 1133849007857 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1133849007858 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1133849007859 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1133849007860 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1133849007861 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326 1133849007862 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1133849007863 putative active site pocket [active] 1133849007864 metal binding site [ion binding]; metal-binding site 1133849007865 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1133849007866 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1133849007867 putative metal binding site [ion binding]; other site 1133849007868 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849007869 Walker A/P-loop; other site 1133849007870 ATP binding site [chemical binding]; other site 1133849007871 Q-loop/lid; other site 1133849007872 ABC transporter signature motif; other site 1133849007873 Walker B; other site 1133849007874 D-loop; other site 1133849007875 H-loop/switch region; other site 1133849007876 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849007877 Walker A/P-loop; other site 1133849007878 ATP binding site [chemical binding]; other site 1133849007879 Q-loop/lid; other site 1133849007880 ABC transporter signature motif; other site 1133849007881 Walker B; other site 1133849007882 D-loop; other site 1133849007883 H-loop/switch region; other site 1133849007884 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849007885 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849007886 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1133849007887 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849007888 Walker A/P-loop; other site 1133849007889 ATP binding site [chemical binding]; other site 1133849007890 Q-loop/lid; other site 1133849007891 ABC transporter signature motif; other site 1133849007892 Walker B; other site 1133849007893 D-loop; other site 1133849007894 H-loop/switch region; other site 1133849007895 ABC transporter; Region: ABC_tran_2; pfam12848 1133849007896 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1133849007897 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1133849007898 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1133849007899 trimer interface [polypeptide binding]; other site 1133849007900 active site 1133849007901 substrate binding site [chemical binding]; other site 1133849007902 CoA binding site [chemical binding]; other site 1133849007903 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1133849007904 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1133849007905 FeS/SAM binding site; other site 1133849007906 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1133849007907 active site 1133849007908 ATP binding site [chemical binding]; other site 1133849007909 substrate binding site [chemical binding]; other site 1133849007910 activation loop (A-loop); other site 1133849007911 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 1133849007912 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cd04434 1133849007913 active site 1133849007914 zinc binding site [ion binding]; other site 1133849007915 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1133849007916 Sulfatase; Region: Sulfatase; cl17466 1133849007917 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1133849007918 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1133849007919 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1133849007920 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1133849007921 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1133849007922 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1133849007923 Walker A/P-loop; other site 1133849007924 ATP binding site [chemical binding]; other site 1133849007925 Q-loop/lid; other site 1133849007926 ABC transporter signature motif; other site 1133849007927 Walker B; other site 1133849007928 D-loop; other site 1133849007929 H-loop/switch region; other site 1133849007930 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1133849007931 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1133849007932 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1133849007933 TM-ABC transporter signature motif; other site 1133849007934 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1133849007935 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1133849007936 Entner-Doudoroff aldolase; Region: eda; TIGR01182 1133849007937 active site 1133849007938 intersubunit interface [polypeptide binding]; other site 1133849007939 catalytic residue [active] 1133849007940 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1133849007941 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1133849007942 substrate binding site [chemical binding]; other site 1133849007943 ATP binding site [chemical binding]; other site 1133849007944 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1133849007945 classical (c) SDRs; Region: SDR_c; cd05233 1133849007946 NAD(P) binding site [chemical binding]; other site 1133849007947 active site 1133849007948 galactonate dehydratase; Provisional; Region: PRK14017 1133849007949 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 1133849007950 putative active site pocket [active] 1133849007951 putative metal binding site [ion binding]; other site 1133849007952 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 1133849007953 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1133849007954 DXD motif; other site 1133849007955 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1133849007956 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 1133849007957 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1133849007958 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1133849007959 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849007960 catalytic residue [active] 1133849007961 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 1133849007962 active site 1133849007963 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1133849007964 putative active site [active] 1133849007965 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849007966 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1133849007967 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1133849007968 DNA binding residues [nucleotide binding] 1133849007969 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1133849007970 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1133849007971 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1133849007972 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1133849007973 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1133849007974 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1133849007975 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1133849007976 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1133849007977 FAD binding domain; Region: FAD_binding_4; pfam01565 1133849007978 acyl-CoA synthetase; Validated; Region: PRK07788 1133849007979 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849007980 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849007981 active site 1133849007982 CoA binding site [chemical binding]; other site 1133849007983 AMP binding site [chemical binding]; other site 1133849007984 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1133849007985 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1133849007986 metal binding site [ion binding]; metal-binding site 1133849007987 active site 1133849007988 I-site; other site 1133849007989 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 1133849007990 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1133849007991 active site 1133849007992 MspA; Region: MspA; pfam09203 1133849007993 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1133849007994 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 1133849007995 putative ligand binding site [chemical binding]; other site 1133849007996 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1133849007997 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1133849007998 substrate binding pocket [chemical binding]; other site 1133849007999 catalytic triad [active] 1133849008000 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1133849008001 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1133849008002 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1133849008003 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1133849008004 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1133849008005 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1133849008006 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1133849008007 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 1133849008008 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1133849008009 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1133849008010 active site 1133849008011 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1133849008012 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1133849008013 extended (e) SDRs; Region: SDR_e; cd08946 1133849008014 NAD(P) binding site [chemical binding]; other site 1133849008015 active site 1133849008016 substrate binding site [chemical binding]; other site 1133849008017 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849008018 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1133849008019 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 1133849008020 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1133849008021 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 1133849008022 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1133849008023 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1133849008024 active site 1133849008025 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1133849008026 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1133849008027 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1133849008028 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1133849008029 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1133849008030 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1133849008031 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1133849008032 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1133849008033 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1133849008034 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1133849008035 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1133849008036 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1133849008037 putative active site [active] 1133849008038 glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209 1133849008039 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1133849008040 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849008041 catalytic residue [active] 1133849008042 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 1133849008043 putative ADP-binding pocket [chemical binding]; other site 1133849008044 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1133849008045 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1133849008046 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1133849008047 NB-ARC domain; Region: NB-ARC; pfam00931 1133849008048 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849008049 AMP-binding enzyme; Region: AMP-binding; pfam00501 1133849008050 acyl-activating enzyme (AAE) consensus motif; other site 1133849008051 AMP binding site [chemical binding]; other site 1133849008052 active site 1133849008053 CoA binding site [chemical binding]; other site 1133849008054 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1133849008055 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1133849008056 putative NADP binding site [chemical binding]; other site 1133849008057 active site 1133849008058 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1133849008059 Condensation domain; Region: Condensation; pfam00668 1133849008060 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849008061 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849008062 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1133849008063 homodimer interface [polypeptide binding]; other site 1133849008064 active site 1133849008065 TDP-binding site; other site 1133849008066 acceptor substrate-binding pocket; other site 1133849008067 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1133849008068 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1133849008069 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1133849008070 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849008071 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1133849008072 acyl-activating enzyme (AAE) consensus motif; other site 1133849008073 AMP binding site [chemical binding]; other site 1133849008074 active site 1133849008075 CoA binding site [chemical binding]; other site 1133849008076 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849008077 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849008078 Cytochrome P450; Region: p450; cl12078 1133849008079 Phosphotransferase enzyme family; Region: APH; pfam01636 1133849008080 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1133849008081 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1133849008082 homodimer interface [polypeptide binding]; other site 1133849008083 active site 1133849008084 TDP-binding site; other site 1133849008085 acceptor substrate-binding pocket; other site 1133849008086 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849008087 Cytochrome P450; Region: p450; cl12078 1133849008088 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849008089 Cytochrome P450; Region: p450; cl12078 1133849008090 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 1133849008091 O-methyltransferase; Region: Methyltransf_2; pfam00891 1133849008092 Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673 1133849008093 Cupin domain; Region: Cupin_2; pfam07883 1133849008094 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1133849008095 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1133849008096 dimer interface [polypeptide binding]; other site 1133849008097 active site 1133849008098 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1133849008099 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1133849008100 active site 1133849008101 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849008102 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1133849008103 hydrophobic ligand binding site; other site 1133849008104 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1133849008105 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849008106 NAD(P) binding site [chemical binding]; other site 1133849008107 active site 1133849008108 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1133849008109 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1133849008110 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1133849008111 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1133849008112 Amidohydrolase; Region: Amidohydro_2; pfam04909 1133849008113 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1133849008114 hypothetical protein; Provisional; Region: PRK07236 1133849008115 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1133849008116 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1133849008117 homodimer interface [polypeptide binding]; other site 1133849008118 active site 1133849008119 TDP-binding site; other site 1133849008120 acceptor substrate-binding pocket; other site 1133849008121 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1133849008122 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1133849008123 active site 1133849008124 TDP-binding site; other site 1133849008125 acceptor substrate-binding pocket; other site 1133849008126 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1133849008127 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1133849008128 inhibitor-cofactor binding pocket; inhibition site 1133849008129 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849008130 catalytic residue [active] 1133849008131 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 1133849008132 putative dimer interface [polypeptide binding]; other site 1133849008133 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849008134 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1133849008135 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1133849008136 active site 1133849008137 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1133849008138 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1133849008139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849008140 S-adenosylmethionine binding site [chemical binding]; other site 1133849008141 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 1133849008142 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849008143 NAD(P) binding site [chemical binding]; other site 1133849008144 active site 1133849008145 UDP-glucose 4-epimerase C-term subunit; Region: Epimerase_Csub; pfam13950 1133849008146 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 1133849008147 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1133849008148 inhibitor-cofactor binding pocket; inhibition site 1133849008149 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849008150 catalytic residue [active] 1133849008151 Histidine kinase; Region: HisKA_3; pfam07730 1133849008152 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1133849008153 Mg2+ binding site [ion binding]; other site 1133849008154 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849008155 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849008156 active site 1133849008157 phosphorylation site [posttranslational modification] 1133849008158 intermolecular recognition site; other site 1133849008159 dimerization interface [polypeptide binding]; other site 1133849008160 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849008161 DNA binding residues [nucleotide binding] 1133849008162 dimerization interface [polypeptide binding]; other site 1133849008163 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849008164 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1133849008165 NAD(P) binding site [chemical binding]; other site 1133849008166 active site 1133849008167 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1133849008168 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1133849008169 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 1133849008170 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 1133849008171 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1133849008172 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1133849008173 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1133849008174 NAD(P) binding site [chemical binding]; other site 1133849008175 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849008176 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1133849008177 catalytic site [active] 1133849008178 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849008179 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849008180 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849008181 Cutinase; Region: Cutinase; pfam01083 1133849008182 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1133849008183 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1133849008184 molybdopterin cofactor binding site; other site 1133849008185 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1133849008186 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1133849008187 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1133849008188 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1133849008189 molybdopterin cofactor binding site; other site 1133849008190 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1133849008191 hydrophobic ligand binding site; other site 1133849008192 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 1133849008193 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1133849008194 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1133849008195 substrate binding site [chemical binding]; other site 1133849008196 ATP binding site [chemical binding]; other site 1133849008197 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1133849008198 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1133849008199 Walker A/P-loop; other site 1133849008200 ATP binding site [chemical binding]; other site 1133849008201 Q-loop/lid; other site 1133849008202 ABC transporter signature motif; other site 1133849008203 Walker B; other site 1133849008204 D-loop; other site 1133849008205 H-loop/switch region; other site 1133849008206 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1133849008207 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1133849008208 TM-ABC transporter signature motif; other site 1133849008209 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1133849008210 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1133849008211 ligand binding site [chemical binding]; other site 1133849008212 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1133849008213 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1133849008214 DNA binding site [nucleotide binding] 1133849008215 domain linker motif; other site 1133849008216 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1133849008217 ligand binding site [chemical binding]; other site 1133849008218 dimerization interface [polypeptide binding]; other site 1133849008219 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1133849008220 FAD binding domain; Region: FAD_binding_4; pfam01565 1133849008221 Berberine and berberine like; Region: BBE; pfam08031 1133849008222 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849008223 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849008224 active site 1133849008225 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1133849008226 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1133849008227 Protein-arginine deiminase (PAD); Region: PAD; pfam03068 1133849008228 Putative cyclase; Region: Cyclase; pfam04199 1133849008229 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1133849008230 A new structural DNA glycosylase; Region: AlkD_like; cd06561 1133849008231 active site 1133849008232 Condensation domain; Region: Condensation; pfam00668 1133849008233 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849008234 Condensation domain; Region: Condensation; pfam00668 1133849008235 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1133849008236 homodimer interface [polypeptide binding]; other site 1133849008237 active site 1133849008238 TDP-binding site; other site 1133849008239 acceptor substrate-binding pocket; other site 1133849008240 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849008241 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1133849008242 Walker A/P-loop; other site 1133849008243 ATP binding site [chemical binding]; other site 1133849008244 Q-loop/lid; other site 1133849008245 ABC transporter signature motif; other site 1133849008246 Walker B; other site 1133849008247 D-loop; other site 1133849008248 H-loop/switch region; other site 1133849008249 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1133849008250 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1133849008251 Secretory lipase; Region: LIP; pfam03583 1133849008252 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1133849008253 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1133849008254 NAD(P) binding site [chemical binding]; other site 1133849008255 substrate binding site [chemical binding]; other site 1133849008256 dimer interface [polypeptide binding]; other site 1133849008257 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849008258 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1133849008259 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1133849008260 hypothetical protein; Provisional; Region: PRK07236 1133849008261 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1133849008262 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1133849008263 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1133849008264 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1133849008265 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1133849008266 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1133849008267 asparagine synthetase A; Reviewed; Region: PRK06462 1133849008268 motif 1; other site 1133849008269 dimer interface [polypeptide binding]; other site 1133849008270 active site 1133849008271 motif 2; other site 1133849008272 motif 3; other site 1133849008273 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1133849008274 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1133849008275 H+ Antiporter protein; Region: 2A0121; TIGR00900 1133849008276 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 1133849008277 B12 binding site [chemical binding]; other site 1133849008278 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1133849008279 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cl02025 1133849008280 substrate binding site [chemical binding]; other site 1133849008281 B12 cofactor binding site [chemical binding]; other site 1133849008282 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 1133849008283 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 1133849008284 hypothetical protein; Provisional; Region: PRK07206 1133849008285 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1133849008286 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1133849008287 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1133849008288 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1133849008289 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cl10033 1133849008290 LBP interface [polypeptide binding]; other site 1133849008291 epsilon subunit interface [polypeptide binding]; other site 1133849008292 gamma subunit interface [polypeptide binding]; other site 1133849008293 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1133849008294 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1133849008295 active site 1133849008296 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1133849008297 putative ADP-binding pocket [chemical binding]; other site 1133849008298 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1133849008299 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1133849008300 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849008301 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849008302 active site 1133849008303 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849008304 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849008305 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849008306 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849008307 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1133849008308 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1133849008309 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1133849008310 catalytic residues [active] 1133849008311 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 1133849008312 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849008313 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1133849008314 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1133849008315 DNA binding residues [nucleotide binding] 1133849008316 hypothetical protein; Provisional; Region: PRK06184 1133849008317 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1133849008318 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849008319 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849008320 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1133849008321 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1133849008322 dimerization interface [polypeptide binding]; other site 1133849008323 substrate binding pocket [chemical binding]; other site 1133849008324 SnoaL-like domain; Region: SnoaL_2; pfam12680 1133849008325 short chain dehydrogenase; Provisional; Region: PRK12744 1133849008326 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1133849008327 NADP binding site [chemical binding]; other site 1133849008328 homodimer interface [polypeptide binding]; other site 1133849008329 active site 1133849008330 substrate binding site [chemical binding]; other site 1133849008331 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1133849008332 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849008333 S-adenosylmethionine binding site [chemical binding]; other site 1133849008334 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849008335 Condensation domain; Region: Condensation; pfam00668 1133849008336 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849008337 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849008338 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1133849008339 acyl-activating enzyme (AAE) consensus motif; other site 1133849008340 AMP binding site [chemical binding]; other site 1133849008341 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849008342 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1133849008343 acyl-activating enzyme (AAE) consensus motif; other site 1133849008344 AMP binding site [chemical binding]; other site 1133849008345 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849008346 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1133849008347 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1133849008348 active site 1133849008349 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1133849008350 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1133849008351 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849008352 Thioesterase domain; Region: Thioesterase; pfam00975 1133849008353 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1133849008354 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1133849008355 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849008356 Cupin domain; Region: Cupin_2; pfam07883 1133849008357 Cupin domain; Region: Cupin_2; pfam07883 1133849008358 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1133849008359 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849008360 dimerization interface [polypeptide binding]; other site 1133849008361 putative Zn2+ binding site [ion binding]; other site 1133849008362 putative DNA binding site [nucleotide binding]; other site 1133849008363 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1133849008364 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1133849008365 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849008366 active site 1133849008367 phosphorylation site [posttranslational modification] 1133849008368 intermolecular recognition site; other site 1133849008369 dimerization interface [polypeptide binding]; other site 1133849008370 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1133849008371 DNA binding site [nucleotide binding] 1133849008372 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1133849008373 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1133849008374 dimerization interface [polypeptide binding]; other site 1133849008375 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1133849008376 dimer interface [polypeptide binding]; other site 1133849008377 phosphorylation site [posttranslational modification] 1133849008378 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849008379 ATP binding site [chemical binding]; other site 1133849008380 Mg2+ binding site [ion binding]; other site 1133849008381 G-X-G motif; other site 1133849008382 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 1133849008383 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1133849008384 putative active site [active] 1133849008385 putative active site [active] 1133849008386 catalytic site [active] 1133849008387 catalytic site [active] 1133849008388 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 1133849008389 PLD-like domain; Region: PLDc_2; pfam13091 1133849008390 putative active site [active] 1133849008391 catalytic site [active] 1133849008392 Putative cyclase; Region: Cyclase; pfam04199 1133849008393 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1133849008394 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1133849008395 homodimer interface [polypeptide binding]; other site 1133849008396 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849008397 catalytic residue [active] 1133849008398 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1133849008399 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1133849008400 conserved cys residue [active] 1133849008401 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849008402 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849008403 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 1133849008404 Predicted transcriptional regulators [Transcription]; Region: COG1733 1133849008405 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1133849008406 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1133849008407 putative sugar binding sites [chemical binding]; other site 1133849008408 Q-X-W motif; other site 1133849008409 tricarballylate dehydrogenase; Validated; Region: PRK08274 1133849008410 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1133849008411 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1133849008412 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1133849008413 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1133849008414 Cupin-like domain; Region: Cupin_8; pfam13621 1133849008415 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1133849008416 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1133849008417 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1133849008418 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1133849008419 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1133849008420 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1133849008421 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1133849008422 ABC-ATPase subunit interface; other site 1133849008423 dimer interface [polypeptide binding]; other site 1133849008424 putative PBP binding regions; other site 1133849008425 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1133849008426 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1133849008427 intersubunit interface [polypeptide binding]; other site 1133849008428 PQQ-like domain; Region: PQQ_2; pfam13360 1133849008429 Erythromycin esterase; Region: Erythro_esteras; pfam05139 1133849008430 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1133849008431 Predicted membrane protein [Function unknown]; Region: COG2261 1133849008432 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849008433 putative Zn2+ binding site [ion binding]; other site 1133849008434 putative DNA binding site [nucleotide binding]; other site 1133849008435 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 1133849008436 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1133849008437 Beta-lactamase; Region: Beta-lactamase; pfam00144 1133849008438 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1133849008439 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1133849008440 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1133849008441 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1133849008442 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1133849008443 DNA-binding site [nucleotide binding]; DNA binding site 1133849008444 FCD domain; Region: FCD; pfam07729 1133849008445 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1133849008446 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849008447 nucleophilic elbow; other site 1133849008448 catalytic triad; other site 1133849008449 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1133849008450 phosphate binding site [ion binding]; other site 1133849008451 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1133849008452 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1133849008453 Bacterial transcriptional regulator; Region: IclR; pfam01614 1133849008454 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1133849008455 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 1133849008456 active site 1133849008457 catalytic site [active] 1133849008458 Zn binding site [ion binding]; other site 1133849008459 tetramer interface [polypeptide binding]; other site 1133849008460 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1133849008461 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1133849008462 metal binding site [ion binding]; metal-binding site 1133849008463 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1133849008464 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849008465 putative Zn2+ binding site [ion binding]; other site 1133849008466 putative DNA binding site [nucleotide binding]; other site 1133849008467 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1133849008468 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1133849008469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849008470 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1133849008471 putative substrate translocation pore; other site 1133849008472 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1133849008473 Sulfatase; Region: Sulfatase; cl17466 1133849008474 Predicted transcriptional regulators [Transcription]; Region: COG1695 1133849008475 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1133849008476 Cytochrome P450; Region: p450; cl12078 1133849008477 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849008478 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1133849008479 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1133849008480 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1133849008481 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849008482 Walker A/P-loop; other site 1133849008483 ATP binding site [chemical binding]; other site 1133849008484 Q-loop/lid; other site 1133849008485 ABC transporter signature motif; other site 1133849008486 Walker B; other site 1133849008487 D-loop; other site 1133849008488 H-loop/switch region; other site 1133849008489 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1133849008490 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1133849008491 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1133849008492 Beta-lactamase; Region: Beta-lactamase; pfam00144 1133849008493 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1133849008494 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1133849008495 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1133849008496 Predicted transcriptional regulators [Transcription]; Region: COG1733 1133849008497 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1133849008498 HEXXH motif domain; Region: mod_HExxH; TIGR04267 1133849008499 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1133849008500 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1133849008501 TPP-binding site [chemical binding]; other site 1133849008502 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1133849008503 PYR/PP interface [polypeptide binding]; other site 1133849008504 dimer interface [polypeptide binding]; other site 1133849008505 TPP binding site [chemical binding]; other site 1133849008506 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 1133849008507 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1133849008508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1133849008509 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1133849008510 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849008511 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1133849008512 active site 1133849008513 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849008514 Cytochrome P450; Region: p450; cl12078 1133849008515 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849008516 Predicted esterase [General function prediction only]; Region: COG0627 1133849008517 S-formylglutathione hydrolase; Region: PLN02442 1133849008518 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1133849008519 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1133849008520 substrate binding pocket [chemical binding]; other site 1133849008521 chain length determination region; other site 1133849008522 substrate-Mg2+ binding site; other site 1133849008523 catalytic residues [active] 1133849008524 aspartate-rich region 1; other site 1133849008525 active site lid residues [active] 1133849008526 aspartate-rich region 2; other site 1133849008527 tocopherol O-methyltransferase; Region: PLN02244 1133849008528 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849008529 S-adenosylmethionine binding site [chemical binding]; other site 1133849008530 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1133849008531 substrate binding pocket [chemical binding]; other site 1133849008532 aspartate-rich region 2; other site 1133849008533 substrate-Mg2+ binding site; other site 1133849008534 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1133849008535 Helix-turn-helix domain; Region: HTH_31; pfam13560 1133849008536 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1133849008537 GAF domain; Region: GAF_3; pfam13492 1133849008538 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1133849008539 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849008540 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849008541 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1133849008542 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1133849008543 active site 1133849008544 catalytic triad [active] 1133849008545 oxyanion hole [active] 1133849008546 Secretory lipase; Region: LIP; pfam03583 1133849008547 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1133849008548 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849008549 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1133849008550 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1133849008551 substrate binding site [chemical binding]; other site 1133849008552 oxyanion hole (OAH) forming residues; other site 1133849008553 trimer interface [polypeptide binding]; other site 1133849008554 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1133849008555 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849008556 NAD(P) binding site [chemical binding]; other site 1133849008557 active site 1133849008558 Predicted transcriptional regulators [Transcription]; Region: COG1733 1133849008559 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1133849008560 short chain dehydrogenase; Validated; Region: PRK08264 1133849008561 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849008562 NAD(P) binding site [chemical binding]; other site 1133849008563 active site 1133849008564 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1133849008565 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849008566 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1133849008567 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1133849008568 DNA binding site [nucleotide binding] 1133849008569 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1133849008570 NB-ARC domain; Region: NB-ARC; pfam00931 1133849008571 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 1133849008572 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1133849008573 TPR motif; other site 1133849008574 binding surface 1133849008575 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849008576 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1133849008577 PAS fold; Region: PAS_3; pfam08447 1133849008578 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1133849008579 putative active site [active] 1133849008580 heme pocket [chemical binding]; other site 1133849008581 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1133849008582 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1133849008583 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849008584 S-adenosylmethionine binding site [chemical binding]; other site 1133849008585 benzoate transport; Region: 2A0115; TIGR00895 1133849008586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849008587 putative substrate translocation pore; other site 1133849008588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849008589 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1133849008590 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1133849008591 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1133849008592 putative dimerization interface [polypeptide binding]; other site 1133849008593 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1133849008594 Class I aldolases; Region: Aldolase_Class_I; cl17187 1133849008595 catalytic residue [active] 1133849008596 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1133849008597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849008598 putative substrate translocation pore; other site 1133849008599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849008600 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1133849008601 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1133849008602 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1133849008603 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1133849008604 RPB1 interaction site [polypeptide binding]; other site 1133849008605 RPB10 interaction site [polypeptide binding]; other site 1133849008606 RPB11 interaction site [polypeptide binding]; other site 1133849008607 RPB3 interaction site [polypeptide binding]; other site 1133849008608 RPB12 interaction site [polypeptide binding]; other site 1133849008609 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1133849008610 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1133849008611 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849008612 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849008613 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849008614 NAD(P) binding site [chemical binding]; other site 1133849008615 active site 1133849008616 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 1133849008617 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1133849008618 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1133849008619 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1133849008620 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849008621 catalytic residue [active] 1133849008622 classical (c) SDRs; Region: SDR_c; cd05233 1133849008623 NAD(P) binding site [chemical binding]; other site 1133849008624 active site 1133849008625 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1133849008626 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1133849008627 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1133849008628 putative OHCU decarboxylase; Provisional; Region: PRK13798 1133849008629 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1133849008630 active site 1133849008631 homotetramer interface [polypeptide binding]; other site 1133849008632 urate oxidase; Region: urate_oxi; TIGR03383 1133849008633 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1133849008634 active site 1133849008635 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1133849008636 FAD binding domain; Region: FAD_binding_4; pfam01565 1133849008637 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1133849008638 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1133849008639 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1133849008640 catalytic loop [active] 1133849008641 iron binding site [ion binding]; other site 1133849008642 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1133849008643 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1133849008644 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 1133849008645 active site 1133849008646 putative substrate binding pocket [chemical binding]; other site 1133849008647 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 1133849008648 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1133849008649 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1133849008650 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1133849008651 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1133849008652 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1133849008653 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1133849008654 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1133849008655 putative active site pocket [active] 1133849008656 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 1133849008657 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1133849008658 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1133849008659 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1133849008660 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1133849008661 TPP-binding site [chemical binding]; other site 1133849008662 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1133849008663 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 1133849008664 allantoinase; Region: allantoinase; TIGR03178 1133849008665 active site 1133849008666 allantoicase; Provisional; Region: PRK13257 1133849008667 Allantoicase repeat; Region: Allantoicase; pfam03561 1133849008668 Allantoicase repeat; Region: Allantoicase; pfam03561 1133849008669 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1133849008670 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849008671 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849008672 Muconolactone delta-isomerase; Region: MIase; cl01992 1133849008673 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1133849008674 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 1133849008675 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1133849008676 tartrate dehydrogenase; Region: TTC; TIGR02089 1133849008677 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1133849008678 transcriptional activator TtdR; Provisional; Region: PRK09801 1133849008679 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1133849008680 dimerization interface [polypeptide binding]; other site 1133849008681 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1133849008682 hydrophobic ligand binding site; other site 1133849008683 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1133849008684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849008685 ATP binding site [chemical binding]; other site 1133849008686 Mg2+ binding site [ion binding]; other site 1133849008687 G-X-G motif; other site 1133849008688 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 1133849008689 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1133849008690 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1133849008691 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1133849008692 G1 box; other site 1133849008693 GTP/Mg2+ binding site [chemical binding]; other site 1133849008694 G2 box; other site 1133849008695 Switch I region; other site 1133849008696 G3 box; other site 1133849008697 Switch II region; other site 1133849008698 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849008699 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849008700 Cytochrome P450; Region: p450; cl12078 1133849008701 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1133849008702 active site 1133849008703 metal binding site [ion binding]; metal-binding site 1133849008704 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849008705 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1133849008706 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1133849008707 Protein of unknown function (DUF3533); Region: DUF3533; pfam12051 1133849008708 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1133849008709 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849008710 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1133849008711 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1133849008712 active site 1133849008713 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1133849008714 CoenzymeA binding site [chemical binding]; other site 1133849008715 subunit interaction site [polypeptide binding]; other site 1133849008716 PHB binding site; other site 1133849008717 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1133849008718 dinuclear metal binding motif [ion binding]; other site 1133849008719 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1133849008720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849008721 S-adenosylmethionine binding site [chemical binding]; other site 1133849008722 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1133849008723 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1133849008724 CoenzymeA binding site [chemical binding]; other site 1133849008725 subunit interaction site [polypeptide binding]; other site 1133849008726 PHB binding site; other site 1133849008727 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1133849008728 dinuclear metal binding motif [ion binding]; other site 1133849008729 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1133849008730 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1133849008731 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 1133849008732 acyl-activating enzyme (AAE) consensus motif; other site 1133849008733 active site 1133849008734 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849008735 Cytochrome P450; Region: p450; cl12078 1133849008736 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849008737 Cytochrome P450; Region: p450; cl12078 1133849008738 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849008739 Cytochrome P450; Region: p450; cl12078 1133849008740 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 1133849008741 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1133849008742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849008743 active site 1133849008744 phosphorylation site [posttranslational modification] 1133849008745 intermolecular recognition site; other site 1133849008746 dimerization interface [polypeptide binding]; other site 1133849008747 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1133849008748 DNA binding site [nucleotide binding] 1133849008749 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1133849008750 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1133849008751 dimerization interface [polypeptide binding]; other site 1133849008752 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1133849008753 dimer interface [polypeptide binding]; other site 1133849008754 phosphorylation site [posttranslational modification] 1133849008755 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849008756 ATP binding site [chemical binding]; other site 1133849008757 Mg2+ binding site [ion binding]; other site 1133849008758 G-X-G motif; other site 1133849008759 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1133849008760 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1133849008761 RNHCP domain; Region: RNHCP; pfam12647 1133849008762 RNHCP domain; Region: RNHCP; pfam12647 1133849008763 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1133849008764 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1133849008765 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1133849008766 DNA-binding site [nucleotide binding]; DNA binding site 1133849008767 FCD domain; Region: FCD; pfam07729 1133849008768 S-formylglutathione hydrolase; Region: PLN02442 1133849008769 Putative esterase; Region: Esterase; pfam00756 1133849008770 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 1133849008771 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1133849008772 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1133849008773 hexamer interface [polypeptide binding]; other site 1133849008774 ligand binding site [chemical binding]; other site 1133849008775 putative active site [active] 1133849008776 NAD(P) binding site [chemical binding]; other site 1133849008777 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1133849008778 AsnC family; Region: AsnC_trans_reg; pfam01037 1133849008779 amidase; Provisional; Region: PRK12470 1133849008780 Amidase; Region: Amidase; pfam01425 1133849008781 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1133849008782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849008783 NAD(P) binding site [chemical binding]; other site 1133849008784 active site 1133849008785 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1133849008786 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849008787 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1133849008788 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1133849008789 PAS domain; Region: PAS_9; pfam13426 1133849008790 amino acid transporter; Region: 2A0306; TIGR00909 1133849008791 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1133849008792 Proline dehydrogenase; Region: Pro_dh; cl03282 1133849008793 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 1133849008794 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 1133849008795 Glutamate binding site [chemical binding]; other site 1133849008796 NAD binding site [chemical binding]; other site 1133849008797 catalytic residues [active] 1133849008798 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1133849008799 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849008800 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849008801 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1133849008802 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1133849008803 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1133849008804 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1133849008805 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1133849008806 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1133849008807 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1133849008808 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1133849008809 active site 1133849008810 ATP binding site [chemical binding]; other site 1133849008811 substrate binding site [chemical binding]; other site 1133849008812 activation loop (A-loop); other site 1133849008813 DNA binding site [nucleotide binding] 1133849008814 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1133849008815 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1133849008816 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1133849008817 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1133849008818 phosphopeptide binding site; other site 1133849008819 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1133849008820 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1133849008821 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1133849008822 dimerization interface [polypeptide binding]; other site 1133849008823 substrate binding pocket [chemical binding]; other site 1133849008824 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1133849008825 acyl-activating enzyme (AAE) consensus motif; other site 1133849008826 putative AMP binding site [chemical binding]; other site 1133849008827 putative active site [active] 1133849008828 putative CoA binding site [chemical binding]; other site 1133849008829 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1133849008830 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 1133849008831 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 1133849008832 active site 1133849008833 catalytic triad [active] 1133849008834 oxyanion hole [active] 1133849008835 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1133849008836 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1133849008837 active site 1133849008838 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1133849008839 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1133849008840 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1133849008841 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1133849008842 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1133849008843 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1133849008844 putative NADP binding site [chemical binding]; other site 1133849008845 active site 1133849008846 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1133849008847 active site 1 [active] 1133849008848 dimer interface [polypeptide binding]; other site 1133849008849 active site 2 [active] 1133849008850 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1133849008851 phosphate binding site [ion binding]; other site 1133849008852 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 1133849008853 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 1133849008854 homodimer interface [polypeptide binding]; other site 1133849008855 putative substrate binding pocket [chemical binding]; other site 1133849008856 diiron center [ion binding]; other site 1133849008857 Secretory lipase; Region: LIP; pfam03583 1133849008858 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1133849008859 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849008860 dimer interface [polypeptide binding]; other site 1133849008861 conserved gate region; other site 1133849008862 putative PBP binding loops; other site 1133849008863 ABC-ATPase subunit interface; other site 1133849008864 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1133849008865 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1133849008866 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1133849008867 active site 1133849008868 metal binding site [ion binding]; metal-binding site 1133849008869 hexamer interface [polypeptide binding]; other site 1133849008870 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1133849008871 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1133849008872 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1133849008873 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1133849008874 Walker A/P-loop; other site 1133849008875 ATP binding site [chemical binding]; other site 1133849008876 Q-loop/lid; other site 1133849008877 ABC transporter signature motif; other site 1133849008878 Walker B; other site 1133849008879 D-loop; other site 1133849008880 H-loop/switch region; other site 1133849008881 TOBE domain; Region: TOBE_2; pfam08402 1133849008882 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 1133849008883 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1133849008884 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1133849008885 CoenzymeA binding site [chemical binding]; other site 1133849008886 subunit interaction site [polypeptide binding]; other site 1133849008887 PHB binding site; other site 1133849008888 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1133849008889 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 1133849008890 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1133849008891 active site 1133849008892 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1133849008893 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1133849008894 FMN-binding pocket [chemical binding]; other site 1133849008895 flavin binding motif; other site 1133849008896 phosphate binding motif [ion binding]; other site 1133849008897 beta-alpha-beta structure motif; other site 1133849008898 NAD binding pocket [chemical binding]; other site 1133849008899 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1133849008900 catalytic loop [active] 1133849008901 iron binding site [ion binding]; other site 1133849008902 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849008903 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849008904 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849008905 Cytochrome P450; Region: p450; cl12078 1133849008906 Protein of unknown function (DUF1271); Region: DUF1271; pfam06902 1133849008907 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 1133849008908 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1133849008909 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1133849008910 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1133849008911 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1133849008912 NAD(P) binding site [chemical binding]; other site 1133849008913 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1133849008914 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1133849008915 MarR family; Region: MarR; pfam01047 1133849008916 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1133849008917 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1133849008918 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1133849008919 Bacterial transcriptional regulator; Region: IclR; pfam01614 1133849008920 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1133849008921 active sites [active] 1133849008922 tetramer interface [polypeptide binding]; other site 1133849008923 urocanate hydratase; Provisional; Region: PRK05414 1133849008924 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1133849008925 allantoate amidohydrolase; Reviewed; Region: PRK09290 1133849008926 active site 1133849008927 metal binding site [ion binding]; metal-binding site 1133849008928 dimer interface [polypeptide binding]; other site 1133849008929 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 1133849008930 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1133849008931 active site 1133849008932 imidazolonepropionase; Provisional; Region: PRK14085 1133849008933 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1133849008934 active site 1133849008935 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1133849008936 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1133849008937 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1133849008938 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1133849008939 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1133849008940 substrate binding pocket [chemical binding]; other site 1133849008941 dimerization interface [polypeptide binding]; other site 1133849008942 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1133849008943 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1133849008944 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1133849008945 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1133849008946 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1133849008947 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1133849008948 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 1133849008949 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1133849008950 active site 1133849008951 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 1133849008952 ABC1 family; Region: ABC1; cl17513 1133849008953 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1133849008954 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 1133849008955 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1133849008956 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849008957 catalytic residue [active] 1133849008958 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849008959 AMP-binding enzyme; Region: AMP-binding; pfam00501 1133849008960 acyl-activating enzyme (AAE) consensus motif; other site 1133849008961 AMP binding site [chemical binding]; other site 1133849008962 active site 1133849008963 CoA binding site [chemical binding]; other site 1133849008964 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1133849008965 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1133849008966 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1133849008967 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 1133849008968 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 1133849008969 tetramer interface [polypeptide binding]; other site 1133849008970 active site 1133849008971 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1133849008972 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1133849008973 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1133849008974 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1133849008975 Walker A/P-loop; other site 1133849008976 ATP binding site [chemical binding]; other site 1133849008977 Q-loop/lid; other site 1133849008978 ABC transporter signature motif; other site 1133849008979 Walker B; other site 1133849008980 D-loop; other site 1133849008981 H-loop/switch region; other site 1133849008982 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1133849008983 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1133849008984 Ligand Binding Site [chemical binding]; other site 1133849008985 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1133849008986 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1133849008987 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1133849008988 cyclase homology domain; Region: CHD; cd07302 1133849008989 nucleotidyl binding site; other site 1133849008990 metal binding site [ion binding]; metal-binding site 1133849008991 dimer interface [polypeptide binding]; other site 1133849008992 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849008993 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849008994 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1133849008995 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1133849008996 proposed catalytic triad [active] 1133849008997 conserved cys residue [active] 1133849008998 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 1133849008999 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1133849009000 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849009001 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1133849009002 acyl-activating enzyme (AAE) consensus motif; other site 1133849009003 putative AMP binding site [chemical binding]; other site 1133849009004 putative active site [active] 1133849009005 putative CoA binding site [chemical binding]; other site 1133849009006 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1133849009007 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1133849009008 active site 1133849009009 ATP binding site [chemical binding]; other site 1133849009010 substrate binding site [chemical binding]; other site 1133849009011 activation loop (A-loop); other site 1133849009012 bile acid transporter; Region: bass; TIGR00841 1133849009013 Sodium Bile acid symporter family; Region: SBF; cl17470 1133849009014 putative oxidoreductase; Provisional; Region: PRK11579 1133849009015 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1133849009016 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1133849009017 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1133849009018 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1133849009019 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1133849009020 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1133849009021 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1133849009022 motif II; other site 1133849009023 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1133849009024 Predicted transcriptional regulators [Transcription]; Region: COG1733 1133849009025 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1133849009026 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1133849009027 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1133849009028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849009029 active site 1133849009030 phosphorylation site [posttranslational modification] 1133849009031 intermolecular recognition site; other site 1133849009032 dimerization interface [polypeptide binding]; other site 1133849009033 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1133849009034 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1133849009035 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849009036 ATP binding site [chemical binding]; other site 1133849009037 Mg2+ binding site [ion binding]; other site 1133849009038 G-X-G motif; other site 1133849009039 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1133849009040 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1133849009041 Walker A/P-loop; other site 1133849009042 ATP binding site [chemical binding]; other site 1133849009043 Q-loop/lid; other site 1133849009044 ABC transporter signature motif; other site 1133849009045 Walker B; other site 1133849009046 D-loop; other site 1133849009047 H-loop/switch region; other site 1133849009048 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1133849009049 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849009050 dimer interface [polypeptide binding]; other site 1133849009051 conserved gate region; other site 1133849009052 putative PBP binding loops; other site 1133849009053 ABC-ATPase subunit interface; other site 1133849009054 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1133849009055 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1133849009056 substrate binding pocket [chemical binding]; other site 1133849009057 membrane-bound complex binding site; other site 1133849009058 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1133849009059 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1133849009060 [2Fe-2S] cluster binding site [ion binding]; other site 1133849009061 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1133849009062 hydrophobic ligand binding site; other site 1133849009063 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849009064 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849009065 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1133849009066 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1133849009067 FAD binding pocket [chemical binding]; other site 1133849009068 FAD binding motif [chemical binding]; other site 1133849009069 phosphate binding motif [ion binding]; other site 1133849009070 NAD binding pocket [chemical binding]; other site 1133849009071 amino acid transporter; Region: 2A0306; TIGR00909 1133849009072 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849009073 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849009074 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1133849009075 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1133849009076 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1133849009077 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849009078 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1133849009079 hypothetical protein; Provisional; Region: PRK07236 1133849009080 hypothetical protein; Provisional; Region: PRK07588 1133849009081 hypothetical protein; Provisional; Region: PRK07236 1133849009082 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1133849009083 ABC1 family; Region: ABC1; cl17513 1133849009084 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1133849009085 putative catalytic site [active] 1133849009086 putative metal binding site [ion binding]; other site 1133849009087 putative phosphate binding site [ion binding]; other site 1133849009088 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1133849009089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849009090 putative substrate translocation pore; other site 1133849009091 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1133849009092 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1133849009093 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1133849009094 active site 1133849009095 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1133849009096 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1133849009097 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849009098 Condensation domain; Region: Condensation; pfam00668 1133849009099 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849009100 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849009101 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849009102 Condensation domain; Region: Condensation; pfam00668 1133849009103 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849009104 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849009105 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849009106 acyl-activating enzyme (AAE) consensus motif; other site 1133849009107 AMP binding site [chemical binding]; other site 1133849009108 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849009109 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1133849009110 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1133849009111 active site 1133849009112 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1133849009113 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1133849009114 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849009115 Condensation domain; Region: Condensation; pfam00668 1133849009116 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849009117 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849009118 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849009119 acyl-activating enzyme (AAE) consensus motif; other site 1133849009120 AMP binding site [chemical binding]; other site 1133849009121 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849009122 S-adenosylmethionine binding site [chemical binding]; other site 1133849009123 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849009124 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849009125 thioester reductase domain; Region: Thioester-redct; TIGR01746 1133849009126 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1133849009127 putative NAD(P) binding site [chemical binding]; other site 1133849009128 active site 1133849009129 putative substrate binding site [chemical binding]; other site 1133849009130 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1133849009131 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1133849009132 acyl-activating enzyme (AAE) consensus motif; other site 1133849009133 active site 1133849009134 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 1133849009135 Acid Phosphatase; Region: Acid_PPase; cl17256 1133849009136 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1133849009137 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1133849009138 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849009139 NAD(P) binding site [chemical binding]; other site 1133849009140 active site 1133849009141 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1133849009142 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849009143 Walker A/P-loop; other site 1133849009144 ATP binding site [chemical binding]; other site 1133849009145 Q-loop/lid; other site 1133849009146 ABC transporter signature motif; other site 1133849009147 Walker B; other site 1133849009148 D-loop; other site 1133849009149 H-loop/switch region; other site 1133849009150 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1133849009151 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1133849009152 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1133849009153 Aromatic prenyltransferase Orf2; Region: PTase_Orf2; pfam11468 1133849009154 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 1133849009155 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1133849009156 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1133849009157 catalytic residues [active] 1133849009158 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1133849009159 nudix motif; other site 1133849009160 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1133849009161 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1133849009162 motif I; other site 1133849009163 motif II; other site 1133849009164 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1133849009165 putative ADP-ribose binding site [chemical binding]; other site 1133849009166 putative active site [active] 1133849009167 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 1133849009168 putative hydrophobic ligand binding site [chemical binding]; other site 1133849009169 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1133849009170 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1133849009171 DNA binding residues [nucleotide binding] 1133849009172 dimer interface [polypeptide binding]; other site 1133849009173 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1133849009174 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1133849009175 active site 1133849009176 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1133849009177 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1133849009178 LGFP repeat; Region: LGFP; pfam08310 1133849009179 LGFP repeat; Region: LGFP; pfam08310 1133849009180 LGFP repeat; Region: LGFP; pfam08310 1133849009181 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1133849009182 LGFP repeat; Region: LGFP; pfam08310 1133849009183 LGFP repeat; Region: LGFP; pfam08310 1133849009184 LGFP repeat; Region: LGFP; pfam08310 1133849009185 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1133849009186 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1133849009187 NAD(P) binding site [chemical binding]; other site 1133849009188 substrate binding site [chemical binding]; other site 1133849009189 dimer interface [polypeptide binding]; other site 1133849009190 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1133849009191 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849009192 S-adenosylmethionine binding site [chemical binding]; other site 1133849009193 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1133849009194 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1133849009195 PYR/PP interface [polypeptide binding]; other site 1133849009196 dimer interface [polypeptide binding]; other site 1133849009197 TPP binding site [chemical binding]; other site 1133849009198 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1133849009199 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1133849009200 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1133849009201 TPP-binding site [chemical binding]; other site 1133849009202 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 1133849009203 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1133849009204 active site 1133849009205 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1133849009206 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1133849009207 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849009208 homodimer interface [polypeptide binding]; other site 1133849009209 catalytic residue [active] 1133849009210 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1133849009211 MarR family; Region: MarR; pfam01047 1133849009212 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 1133849009213 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1133849009214 active site 1133849009215 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 1133849009216 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1133849009217 Dimer interface [polypeptide binding]; other site 1133849009218 anticodon binding site; other site 1133849009219 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1133849009220 motif 1; other site 1133849009221 dimer interface [polypeptide binding]; other site 1133849009222 active site 1133849009223 motif 2; other site 1133849009224 motif 3; other site 1133849009225 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849009226 NAD(P) binding site [chemical binding]; other site 1133849009227 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1133849009228 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1133849009229 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849009230 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1133849009231 NAD(P) binding site [chemical binding]; other site 1133849009232 active site 1133849009233 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849009234 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849009235 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 1133849009236 L-aspartate oxidase; Provisional; Region: PRK06175 1133849009237 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1133849009238 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1133849009239 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1133849009240 Walker A/P-loop; other site 1133849009241 ATP binding site [chemical binding]; other site 1133849009242 Q-loop/lid; other site 1133849009243 ABC transporter signature motif; other site 1133849009244 Walker B; other site 1133849009245 D-loop; other site 1133849009246 H-loop/switch region; other site 1133849009247 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1133849009248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849009249 dimer interface [polypeptide binding]; other site 1133849009250 conserved gate region; other site 1133849009251 putative PBP binding loops; other site 1133849009252 ABC-ATPase subunit interface; other site 1133849009253 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1133849009254 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1133849009255 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1133849009256 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1133849009257 DNA-binding site [nucleotide binding]; DNA binding site 1133849009258 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1133849009259 UTRA domain; Region: UTRA; pfam07702 1133849009260 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849009261 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1133849009262 DNA-binding interface [nucleotide binding]; DNA binding site 1133849009263 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1133849009264 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1133849009265 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849009266 active site 1133849009267 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1133849009268 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1133849009269 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1133849009270 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1133849009271 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1133849009272 CysD dimerization site [polypeptide binding]; other site 1133849009273 G1 box; other site 1133849009274 putative GEF interaction site [polypeptide binding]; other site 1133849009275 GTP/Mg2+ binding site [chemical binding]; other site 1133849009276 Switch I region; other site 1133849009277 G2 box; other site 1133849009278 G3 box; other site 1133849009279 Switch II region; other site 1133849009280 G4 box; other site 1133849009281 G5 box; other site 1133849009282 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1133849009283 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1133849009284 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1133849009285 ligand-binding site [chemical binding]; other site 1133849009286 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1133849009287 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1133849009288 Active Sites [active] 1133849009289 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1133849009290 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1133849009291 short chain dehydrogenase; Provisional; Region: PRK07890 1133849009292 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849009293 NAD(P) binding site [chemical binding]; other site 1133849009294 active site 1133849009295 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1133849009296 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1133849009297 CoenzymeA binding site [chemical binding]; other site 1133849009298 subunit interaction site [polypeptide binding]; other site 1133849009299 PHB binding site; other site 1133849009300 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1133849009301 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1133849009302 motif II; other site 1133849009303 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1133849009304 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849009305 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1133849009306 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1133849009307 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1133849009308 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1133849009309 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849009310 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1133849009311 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1133849009312 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849009313 Walker A/P-loop; other site 1133849009314 ATP binding site [chemical binding]; other site 1133849009315 Q-loop/lid; other site 1133849009316 ABC transporter signature motif; other site 1133849009317 Walker B; other site 1133849009318 D-loop; other site 1133849009319 H-loop/switch region; other site 1133849009320 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 1133849009321 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1133849009322 DNA-binding site [nucleotide binding]; DNA binding site 1133849009323 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1133849009324 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1133849009325 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1133849009326 active site 1133849009327 catalytic residues [active] 1133849009328 metal binding site [ion binding]; metal-binding site 1133849009329 Predicted ATPase [General function prediction only]; Region: COG3903 1133849009330 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849009331 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849009332 DNA binding residues [nucleotide binding] 1133849009333 dimerization interface [polypeptide binding]; other site 1133849009334 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1133849009335 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1133849009336 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1133849009337 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1133849009338 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1133849009339 active site 1133849009340 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1133849009341 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1133849009342 nucleotide binding site [chemical binding]; other site 1133849009343 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 1133849009344 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1133849009345 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1133849009346 catalytic residues [active] 1133849009347 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1133849009348 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 1133849009349 N- and C-terminal domain interface [polypeptide binding]; other site 1133849009350 putative active site [active] 1133849009351 MgATP binding site [chemical binding]; other site 1133849009352 catalytic site [active] 1133849009353 metal binding site [ion binding]; metal-binding site 1133849009354 putative xylulose binding site [chemical binding]; other site 1133849009355 putative homodimer interface [polypeptide binding]; other site 1133849009356 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 1133849009357 active site 1133849009358 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1133849009359 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849009360 Walker A/P-loop; other site 1133849009361 ATP binding site [chemical binding]; other site 1133849009362 Q-loop/lid; other site 1133849009363 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849009364 ABC transporter signature motif; other site 1133849009365 Walker B; other site 1133849009366 D-loop; other site 1133849009367 H-loop/switch region; other site 1133849009368 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849009369 Walker A/P-loop; other site 1133849009370 ATP binding site [chemical binding]; other site 1133849009371 Q-loop/lid; other site 1133849009372 ABC transporter signature motif; other site 1133849009373 Walker B; other site 1133849009374 D-loop; other site 1133849009375 H-loop/switch region; other site 1133849009376 HTH domain; Region: HTH_11; pfam08279 1133849009377 Predicted transcriptional regulator [Transcription]; Region: COG2378 1133849009378 WYL domain; Region: WYL; pfam13280 1133849009379 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1133849009380 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1133849009381 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1133849009382 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1133849009383 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1133849009384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849009385 S-adenosylmethionine binding site [chemical binding]; other site 1133849009386 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1133849009387 short chain dehydrogenase; Provisional; Region: PRK07814 1133849009388 classical (c) SDRs; Region: SDR_c; cd05233 1133849009389 NAD(P) binding site [chemical binding]; other site 1133849009390 active site 1133849009391 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1133849009392 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1133849009393 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1133849009394 active site 1133849009395 substrate binding site [chemical binding]; other site 1133849009396 FMN binding site [chemical binding]; other site 1133849009397 putative catalytic residues [active] 1133849009398 short chain dehydrogenase; Provisional; Region: PRK06138 1133849009399 classical (c) SDRs; Region: SDR_c; cd05233 1133849009400 NAD(P) binding site [chemical binding]; other site 1133849009401 active site 1133849009402 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1133849009403 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1133849009404 metal binding site [ion binding]; metal-binding site 1133849009405 substrate binding pocket [chemical binding]; other site 1133849009406 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1133849009407 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1133849009408 ligand binding site [chemical binding]; other site 1133849009409 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1133849009410 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1133849009411 Walker A/P-loop; other site 1133849009412 ATP binding site [chemical binding]; other site 1133849009413 Q-loop/lid; other site 1133849009414 ABC transporter signature motif; other site 1133849009415 Walker B; other site 1133849009416 D-loop; other site 1133849009417 H-loop/switch region; other site 1133849009418 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1133849009419 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1133849009420 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1133849009421 TM-ABC transporter signature motif; other site 1133849009422 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1133849009423 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1133849009424 active site 1133849009425 catalytic tetrad [active] 1133849009426 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1133849009427 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1133849009428 DNA-binding site [nucleotide binding]; DNA binding site 1133849009429 FCD domain; Region: FCD; pfam07729 1133849009430 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1133849009431 Amidohydrolase; Region: Amidohydro_2; pfam04909 1133849009432 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1133849009433 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1133849009434 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1133849009435 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1133849009436 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849009437 catalytic residue [active] 1133849009438 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1133849009439 The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693 1133849009440 TIR domain; Region: TIR_2; pfam13676 1133849009441 AAA ATPase domain; Region: AAA_16; pfam13191 1133849009442 AAA domain; Region: AAA_22; pfam13401 1133849009443 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1133849009444 binding surface 1133849009445 TPR motif; other site 1133849009446 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849009447 AAA ATPase domain; Region: AAA_16; pfam13191 1133849009448 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849009449 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849009450 Tetratricopeptide repeat; Region: TPR_10; cl17452 1133849009451 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1133849009452 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849009453 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849009454 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1133849009455 AAA ATPase domain; Region: AAA_16; pfam13191 1133849009456 Predicted ATPase [General function prediction only]; Region: COG3899 1133849009457 SnoaL-like domain; Region: SnoaL_4; pfam13577 1133849009458 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849009459 dimerization interface [polypeptide binding]; other site 1133849009460 putative DNA binding site [nucleotide binding]; other site 1133849009461 putative Zn2+ binding site [ion binding]; other site 1133849009462 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1133849009463 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1133849009464 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1133849009465 Bacterial transcriptional regulator; Region: IclR; pfam01614 1133849009466 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1133849009467 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1133849009468 active site 1133849009469 domain interfaces; other site 1133849009470 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849009471 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849009472 active site 1133849009473 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1133849009474 Pollen allergen; Region: Pollen_allerg_1; cl08320 1133849009475 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1133849009476 FAD binding domain; Region: FAD_binding_2; pfam00890 1133849009477 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849009478 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849009479 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1133849009480 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 1133849009481 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 1133849009482 putative NAD(P) binding site [chemical binding]; other site 1133849009483 putative substrate binding site [chemical binding]; other site 1133849009484 catalytic Zn binding site [ion binding]; other site 1133849009485 structural Zn binding site [ion binding]; other site 1133849009486 Cutinase; Region: Cutinase; pfam01083 1133849009487 short chain dehydrogenase; Provisional; Region: PRK07201 1133849009488 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 1133849009489 putative NAD(P) binding site [chemical binding]; other site 1133849009490 active site 1133849009491 putative substrate binding site [chemical binding]; other site 1133849009492 classical (c) SDRs; Region: SDR_c; cd05233 1133849009493 NAD(P) binding site [chemical binding]; other site 1133849009494 active site 1133849009495 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1133849009496 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1133849009497 putative active site [active] 1133849009498 putative metal binding site [ion binding]; other site 1133849009499 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1133849009500 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1133849009501 putative catalytic site [active] 1133849009502 putative metal binding site [ion binding]; other site 1133849009503 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849009504 Walker B; other site 1133849009505 D-loop; other site 1133849009506 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 1133849009507 putative ADP-binding pocket [chemical binding]; other site 1133849009508 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1133849009509 glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209 1133849009510 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1133849009511 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849009512 catalytic residue [active] 1133849009513 Predicted transcriptional regulators [Transcription]; Region: COG1725 1133849009514 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1133849009515 DNA-binding site [nucleotide binding]; DNA binding site 1133849009516 classical (c) SDRs; Region: SDR_c; cd05233 1133849009517 NAD(P) binding site [chemical binding]; other site 1133849009518 active site 1133849009519 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1133849009520 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1133849009521 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1133849009522 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1133849009523 Chain length determinant protein; Region: Wzz; cl15801 1133849009524 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 1133849009525 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1133849009526 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1133849009527 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1133849009528 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1133849009529 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1133849009530 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1133849009531 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1133849009532 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1133849009533 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1133849009534 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849009535 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849009536 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1133849009537 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1133849009538 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1133849009539 active site 1133849009540 MspA; Region: MspA; pfam09203 1133849009541 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 1133849009542 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 1133849009543 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1133849009544 extended (e) SDRs; Region: SDR_e; cd08946 1133849009545 NAD(P) binding site [chemical binding]; other site 1133849009546 active site 1133849009547 substrate binding site [chemical binding]; other site 1133849009548 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1133849009549 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1133849009550 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1133849009551 active site 1133849009552 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 1133849009553 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1133849009554 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1133849009555 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 1133849009556 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1133849009557 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1133849009558 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1133849009559 heme binding pocket [chemical binding]; other site 1133849009560 heme ligand [chemical binding]; other site 1133849009561 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1133849009562 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1133849009563 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1133849009564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849009565 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1133849009566 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1133849009567 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1133849009568 dimerization interface [polypeptide binding]; other site 1133849009569 FAD binding domain; Region: FAD_binding_3; pfam01494 1133849009570 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1133849009571 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1133849009572 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 1133849009573 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849009574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849009575 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1133849009576 putative substrate translocation pore; other site 1133849009577 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1133849009578 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1133849009579 putative acyl-acceptor binding pocket; other site 1133849009580 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1133849009581 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849009582 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849009583 active site 1133849009584 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849009585 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849009586 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1133849009587 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1133849009588 Walker A/P-loop; other site 1133849009589 ATP binding site [chemical binding]; other site 1133849009590 Q-loop/lid; other site 1133849009591 ABC transporter signature motif; other site 1133849009592 Walker B; other site 1133849009593 D-loop; other site 1133849009594 H-loop/switch region; other site 1133849009595 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1133849009596 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1133849009597 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1133849009598 short chain dehydrogenase; Provisional; Region: PRK12746 1133849009599 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849009600 NAD(P) binding site [chemical binding]; other site 1133849009601 active site 1133849009602 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1133849009603 active site 1133849009604 Predicted ATPase [General function prediction only]; Region: COG3903 1133849009605 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849009606 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849009607 DNA binding residues [nucleotide binding] 1133849009608 dimerization interface [polypeptide binding]; other site 1133849009609 Nuclease-related domain; Region: NERD; pfam08378 1133849009610 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 1133849009611 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 1133849009612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 1133849009613 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1133849009614 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1133849009615 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1133849009616 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1133849009617 lipoyl attachment site [posttranslational modification]; other site 1133849009618 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1133849009619 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1133849009620 phosphopeptide binding site; other site 1133849009621 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1133849009622 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1133849009623 DNA binding residues [nucleotide binding] 1133849009624 dimer interface [polypeptide binding]; other site 1133849009625 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1133849009626 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1133849009627 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1133849009628 DNA binding residues [nucleotide binding] 1133849009629 putative dimer interface [polypeptide binding]; other site 1133849009630 glycine dehydrogenase; Provisional; Region: PRK05367 1133849009631 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1133849009632 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849009633 catalytic residue [active] 1133849009634 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1133849009635 tetramer interface [polypeptide binding]; other site 1133849009636 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849009637 catalytic residue [active] 1133849009638 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1133849009639 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1133849009640 metal ion-dependent adhesion site (MIDAS); other site 1133849009641 Transcription factor WhiB; Region: Whib; pfam02467 1133849009642 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1133849009643 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1133849009644 active site 1133849009645 potential frameshift: common BLAST hit: gi|345002795|ref|YP_004805649.1| major facilitator superfamily protein 1133849009646 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1133849009647 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1133849009648 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1133849009649 Electron transfer DM13; Region: DM13; pfam10517 1133849009650 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849009651 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849009652 active site 1133849009653 Predicted transcriptional regulators [Transcription]; Region: COG1733 1133849009654 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1133849009655 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1133849009656 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849009657 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849009658 active site 1133849009659 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849009660 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849009661 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 2; Region: FDH_like_2; cd08284 1133849009662 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1133849009663 catalytic Zn binding site [ion binding]; other site 1133849009664 NAD(P) binding site [chemical binding]; other site 1133849009665 structural Zn binding site [ion binding]; other site 1133849009666 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1133849009667 classical (c) SDRs; Region: SDR_c; cd05233 1133849009668 NAD(P) binding site [chemical binding]; other site 1133849009669 active site 1133849009670 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1133849009671 active site 1133849009672 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849009673 dimerization interface [polypeptide binding]; other site 1133849009674 putative DNA binding site [nucleotide binding]; other site 1133849009675 putative Zn2+ binding site [ion binding]; other site 1133849009676 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1133849009677 active site 1133849009678 substrate-binding site [chemical binding]; other site 1133849009679 metal-binding site [ion binding] 1133849009680 GTP binding site [chemical binding]; other site 1133849009681 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1133849009682 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1133849009683 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1133849009684 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1133849009685 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1133849009686 putative substrate binding site [chemical binding]; other site 1133849009687 putative ATP binding site [chemical binding]; other site 1133849009688 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1133849009689 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1133849009690 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1133849009691 active site 1133849009692 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1133849009693 arsenical-resistance protein; Region: acr3; TIGR00832 1133849009694 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849009695 dimerization interface [polypeptide binding]; other site 1133849009696 putative DNA binding site [nucleotide binding]; other site 1133849009697 putative Zn2+ binding site [ion binding]; other site 1133849009698 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 1133849009699 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849009700 putative metal binding site [ion binding]; other site 1133849009701 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849009702 dimerization interface [polypeptide binding]; other site 1133849009703 putative DNA binding site [nucleotide binding]; other site 1133849009704 putative Zn2+ binding site [ion binding]; other site 1133849009705 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1133849009706 Domain of unknown function DUF302; Region: DUF302; cl01364 1133849009707 Short C-terminal domain; Region: SHOCT; pfam09851 1133849009708 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1133849009709 Ligand Binding Site [chemical binding]; other site 1133849009710 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1133849009711 Ligand Binding Site [chemical binding]; other site 1133849009712 Beta-lactamase; Region: Beta-lactamase; pfam00144 1133849009713 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1133849009714 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1133849009715 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1133849009716 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 1133849009717 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1133849009718 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1133849009719 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 1133849009720 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1133849009721 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1133849009722 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1133849009723 motif II; other site 1133849009724 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1133849009725 PAP2 superfamily; Region: PAP2; pfam01569 1133849009726 active site 1133849009727 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1133849009728 active site 1133849009729 ATP binding site [chemical binding]; other site 1133849009730 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 1133849009731 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1133849009732 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1133849009733 putative dimer interface [polypeptide binding]; other site 1133849009734 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1133849009735 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1133849009736 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1133849009737 Ligand Binding Site [chemical binding]; other site 1133849009738 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1133849009739 Ligand Binding Site [chemical binding]; other site 1133849009740 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1133849009741 Ligand Binding Site [chemical binding]; other site 1133849009742 Universal stress protein family; Region: Usp; pfam00582 1133849009743 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1133849009744 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1133849009745 GAF domain; Region: GAF_3; pfam13492 1133849009746 Histidine kinase; Region: HisKA_3; pfam07730 1133849009747 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1133849009748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849009749 ATP binding site [chemical binding]; other site 1133849009750 Mg2+ binding site [ion binding]; other site 1133849009751 G-X-G motif; other site 1133849009752 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849009753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849009754 active site 1133849009755 phosphorylation site [posttranslational modification] 1133849009756 intermolecular recognition site; other site 1133849009757 dimerization interface [polypeptide binding]; other site 1133849009758 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849009759 DNA binding residues [nucleotide binding] 1133849009760 dimerization interface [polypeptide binding]; other site 1133849009761 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1133849009762 Predicted kinase [General function prediction only]; Region: COG0645 1133849009763 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1133849009764 active site 1133849009765 hypothetical protein; Provisional; Region: PRK14851 1133849009766 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1133849009767 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1133849009768 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849009769 NAD(P) binding site [chemical binding]; other site 1133849009770 active site 1133849009771 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1133849009772 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1133849009773 Predicted transcriptional regulators [Transcription]; Region: COG1733 1133849009774 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849009775 dimerization interface [polypeptide binding]; other site 1133849009776 putative DNA binding site [nucleotide binding]; other site 1133849009777 putative Zn2+ binding site [ion binding]; other site 1133849009778 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1133849009779 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1133849009780 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 1133849009781 Carboxylesterase family; Region: COesterase; pfam00135 1133849009782 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1133849009783 substrate binding pocket [chemical binding]; other site 1133849009784 catalytic triad [active] 1133849009785 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1133849009786 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1133849009787 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1133849009788 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1133849009789 Walker A/P-loop; other site 1133849009790 ATP binding site [chemical binding]; other site 1133849009791 Q-loop/lid; other site 1133849009792 ABC transporter signature motif; other site 1133849009793 Walker B; other site 1133849009794 D-loop; other site 1133849009795 H-loop/switch region; other site 1133849009796 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1133849009797 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849009798 NAD(P) binding site [chemical binding]; other site 1133849009799 active site 1133849009800 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1133849009801 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1133849009802 motif II; other site 1133849009803 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1133849009804 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1133849009805 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1133849009806 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1133849009807 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1133849009808 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 1133849009809 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1133849009810 Ligand Binding Site [chemical binding]; other site 1133849009811 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 1133849009812 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1133849009813 catalytic Zn binding site [ion binding]; other site 1133849009814 structural Zn binding site [ion binding]; other site 1133849009815 NAD(P) binding site [chemical binding]; other site 1133849009816 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1133849009817 Ligand Binding Site [chemical binding]; other site 1133849009818 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1133849009819 Ligand Binding Site [chemical binding]; other site 1133849009820 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1133849009821 Ligand Binding Site [chemical binding]; other site 1133849009822 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1133849009823 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1133849009824 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1133849009825 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1133849009826 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1133849009827 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1133849009828 Ligand Binding Site [chemical binding]; other site 1133849009829 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1133849009830 Ligand Binding Site [chemical binding]; other site 1133849009831 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1133849009832 Ligand Binding Site [chemical binding]; other site 1133849009833 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1133849009834 Ligand Binding Site [chemical binding]; other site 1133849009835 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1133849009836 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1133849009837 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1133849009838 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1133849009839 motif II; other site 1133849009840 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1133849009841 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1133849009842 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1133849009843 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1133849009844 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1133849009845 metal-binding site [ion binding] 1133849009846 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1133849009847 Cupin-like domain; Region: Cupin_8; pfam13621 1133849009848 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1133849009849 active site 1133849009850 catalytic residues [active] 1133849009851 metal binding site [ion binding]; metal-binding site 1133849009852 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849009853 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 1133849009854 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1133849009855 NAD binding site [chemical binding]; other site 1133849009856 catalytic Zn binding site [ion binding]; other site 1133849009857 substrate binding site [chemical binding]; other site 1133849009858 structural Zn binding site [ion binding]; other site 1133849009859 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1133849009860 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1133849009861 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1133849009862 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1133849009863 [2Fe-2S] cluster binding site [ion binding]; other site 1133849009864 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1133849009865 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1133849009866 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 1133849009867 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1133849009868 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1133849009869 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1133849009870 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1133849009871 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1133849009872 [2Fe-2S] cluster binding site [ion binding]; other site 1133849009873 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 1133849009874 putative alpha subunit interface [polypeptide binding]; other site 1133849009875 putative active site [active] 1133849009876 putative substrate binding site [chemical binding]; other site 1133849009877 Fe binding site [ion binding]; other site 1133849009878 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 1133849009879 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1133849009880 tetramerization interface [polypeptide binding]; other site 1133849009881 NAD(P) binding site [chemical binding]; other site 1133849009882 catalytic residues [active] 1133849009883 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 1133849009884 choline dehydrogenase; Validated; Region: PRK02106 1133849009885 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1133849009886 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 1133849009887 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1133849009888 ligand binding site [chemical binding]; other site 1133849009889 flexible hinge region; other site 1133849009890 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 1133849009891 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1133849009892 metal binding triad; other site 1133849009893 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1133849009894 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1133849009895 Bacterial transcriptional regulator; Region: IclR; pfam01614 1133849009896 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1133849009897 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1133849009898 dimer interface [polypeptide binding]; other site 1133849009899 active site 1133849009900 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1133849009901 folate binding site [chemical binding]; other site 1133849009902 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1133849009903 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1133849009904 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1133849009905 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1133849009906 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1133849009907 heme-binding site [chemical binding]; other site 1133849009908 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1133849009909 FAD binding pocket [chemical binding]; other site 1133849009910 FAD binding motif [chemical binding]; other site 1133849009911 phosphate binding motif [ion binding]; other site 1133849009912 beta-alpha-beta structure motif; other site 1133849009913 NAD binding pocket [chemical binding]; other site 1133849009914 Heme binding pocket [chemical binding]; other site 1133849009915 Predicted transcriptional regulator [Transcription]; Region: COG1959 1133849009916 Transcriptional regulator; Region: Rrf2; cl17282 1133849009917 Putative esterase; Region: Esterase; pfam00756 1133849009918 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1133849009919 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1133849009920 active site 1 [active] 1133849009921 active site 2 [active] 1133849009922 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 1133849009923 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849009924 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1133849009925 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1133849009926 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1133849009927 active site 1133849009928 (T/H)XGH motif; other site 1133849009929 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1133849009930 FAD binding domain; Region: FAD_binding_4; pfam01565 1133849009931 Berberine and berberine like; Region: BBE; pfam08031 1133849009932 Nucleoside Triphosphate Pyrophosphohydrolase EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u6; cd11543 1133849009933 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1133849009934 active site 1133849009935 Zn binding site [ion binding]; other site 1133849009936 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 1133849009937 active site 1133849009938 conformational flexibility of ligand binding pocket; other site 1133849009939 ADP-ribosylating toxin turn-turn motif; other site 1133849009940 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1133849009941 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849009942 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1133849009943 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849009944 SnoaL-like domain; Region: SnoaL_2; pfam12680 1133849009945 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 1133849009946 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849009947 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849009948 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 1133849009949 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1133849009950 Carboxylesterase family; Region: COesterase; pfam00135 1133849009951 substrate binding pocket [chemical binding]; other site 1133849009952 catalytic triad [active] 1133849009953 MarR family; Region: MarR_2; pfam12802 1133849009954 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1133849009955 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1133849009956 PQQ-like domain; Region: PQQ_2; pfam13360 1133849009957 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1133849009958 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1133849009959 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1133849009960 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1133849009961 GAF domain; Region: GAF; pfam01590 1133849009962 GAF domain; Region: GAF_3; pfam13492 1133849009963 Histidine kinase; Region: HisKA_3; pfam07730 1133849009964 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1133849009965 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849009966 ATP binding site [chemical binding]; other site 1133849009967 Mg2+ binding site [ion binding]; other site 1133849009968 G-X-G motif; other site 1133849009969 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849009970 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849009971 active site 1133849009972 phosphorylation site [posttranslational modification] 1133849009973 intermolecular recognition site; other site 1133849009974 dimerization interface [polypeptide binding]; other site 1133849009975 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849009976 DNA binding residues [nucleotide binding] 1133849009977 TAP-like protein; Region: Abhydrolase_4; pfam08386 1133849009978 hypothetical protein; Provisional; Region: PRK07877 1133849009979 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1133849009980 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1133849009981 dimer interface [polypeptide binding]; other site 1133849009982 active site 1133849009983 heme binding site [chemical binding]; other site 1133849009984 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1133849009985 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1133849009986 metal binding site 2 [ion binding]; metal-binding site 1133849009987 putative DNA binding helix; other site 1133849009988 metal binding site 1 [ion binding]; metal-binding site 1133849009989 dimer interface [polypeptide binding]; other site 1133849009990 structural Zn2+ binding site [ion binding]; other site 1133849009991 Putative esterase; Region: Esterase; pfam00756 1133849009992 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1133849009993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849009994 putative substrate translocation pore; other site 1133849009995 acyl-CoA synthetase; Validated; Region: PRK07788 1133849009996 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849009997 acyl-activating enzyme (AAE) consensus motif; other site 1133849009998 AMP binding site [chemical binding]; other site 1133849009999 active site 1133849010000 CoA binding site [chemical binding]; other site 1133849010001 Putative esterase; Region: Esterase; pfam00756 1133849010002 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1133849010003 Condensation domain; Region: Condensation; pfam00668 1133849010004 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1133849010005 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1133849010006 active site 1133849010007 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1133849010008 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1133849010009 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849010010 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1133849010011 Enoylreductase; Region: PKS_ER; smart00829 1133849010012 NAD(P) binding site [chemical binding]; other site 1133849010013 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849010014 KR domain; Region: KR; pfam08659 1133849010015 NAD(P) binding site [chemical binding]; other site 1133849010016 active site 1133849010017 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1133849010018 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1133849010019 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1133849010020 hydrophobic ligand binding site; other site 1133849010021 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849010022 dimerization interface [polypeptide binding]; other site 1133849010023 putative DNA binding site [nucleotide binding]; other site 1133849010024 putative Zn2+ binding site [ion binding]; other site 1133849010025 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1133849010026 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849010027 active site 1133849010028 Heavy-metal-associated domain; Region: HMA; pfam00403 1133849010029 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1133849010030 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1133849010031 Walker A/P-loop; other site 1133849010032 ATP binding site [chemical binding]; other site 1133849010033 Q-loop/lid; other site 1133849010034 ABC transporter signature motif; other site 1133849010035 Walker B; other site 1133849010036 D-loop; other site 1133849010037 H-loop/switch region; other site 1133849010038 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1133849010039 Histidine kinase; Region: HisKA_3; pfam07730 1133849010040 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849010041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849010042 active site 1133849010043 phosphorylation site [posttranslational modification] 1133849010044 intermolecular recognition site; other site 1133849010045 dimerization interface [polypeptide binding]; other site 1133849010046 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849010047 DNA binding residues [nucleotide binding] 1133849010048 dimerization interface [polypeptide binding]; other site 1133849010049 TAP-like protein; Region: Abhydrolase_4; pfam08386 1133849010050 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1133849010051 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1133849010052 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1133849010053 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1133849010054 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1133849010055 DNA binding residues [nucleotide binding] 1133849010056 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1133849010057 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849010058 sequence-specific DNA binding site [nucleotide binding]; other site 1133849010059 salt bridge; other site 1133849010060 bile acid transporter; Region: bass; TIGR00841 1133849010061 Sodium Bile acid symporter family; Region: SBF; cl17470 1133849010062 Low affinity iron permease; Region: Iron_permease; cl12096 1133849010063 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1133849010064 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1133849010065 Coenzyme A binding pocket [chemical binding]; other site 1133849010066 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1133849010067 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1133849010068 DNA-binding site [nucleotide binding]; DNA binding site 1133849010069 UTRA domain; Region: UTRA; pfam07702 1133849010070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849010071 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1133849010072 putative substrate translocation pore; other site 1133849010073 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1133849010074 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1133849010075 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1133849010076 dimer interface [polypeptide binding]; other site 1133849010077 active site 1133849010078 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1133849010079 dimer interface [polypeptide binding]; other site 1133849010080 active site 1133849010081 Beta-lactamase; Region: Beta-lactamase; pfam00144 1133849010082 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1133849010083 LGFP repeat; Region: LGFP; pfam08310 1133849010084 LGFP repeat; Region: LGFP; pfam08310 1133849010085 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1133849010086 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1133849010087 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1133849010088 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1133849010089 active site 1133849010090 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1133849010091 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1133849010092 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1133849010093 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1133849010094 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849010095 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1133849010096 Enoylreductase; Region: PKS_ER; smart00829 1133849010097 NAD(P) binding site [chemical binding]; other site 1133849010098 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1133849010099 KR domain; Region: KR; pfam08659 1133849010100 putative NADP binding site [chemical binding]; other site 1133849010101 active site 1133849010102 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1133849010103 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1133849010104 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1133849010105 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1133849010106 short chain dehydrogenase; Provisional; Region: PRK08278 1133849010107 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849010108 NAD(P) binding site [chemical binding]; other site 1133849010109 active site 1133849010110 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 1133849010111 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849010112 acyl-activating enzyme (AAE) consensus motif; other site 1133849010113 AMP binding site [chemical binding]; other site 1133849010114 active site 1133849010115 CoA binding site [chemical binding]; other site 1133849010116 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849010117 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1133849010118 CoenzymeA binding site [chemical binding]; other site 1133849010119 subunit interaction site [polypeptide binding]; other site 1133849010120 PHB binding site; other site 1133849010121 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1133849010122 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1133849010123 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849010124 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849010125 DNA binding residues [nucleotide binding] 1133849010126 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1133849010127 putative active site pocket [active] 1133849010128 cleavage site 1133849010129 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1133849010130 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1133849010131 active site 1133849010132 ATP-binding site [chemical binding]; other site 1133849010133 pantoate-binding site; other site 1133849010134 HXXH motif; other site 1133849010135 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1133849010136 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 1133849010137 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1133849010138 active site 1133849010139 iron coordination sites [ion binding]; other site 1133849010140 substrate binding pocket [chemical binding]; other site 1133849010141 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1133849010142 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 1133849010143 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1133849010144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849010145 dimer interface [polypeptide binding]; other site 1133849010146 conserved gate region; other site 1133849010147 putative PBP binding loops; other site 1133849010148 ABC-ATPase subunit interface; other site 1133849010149 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1133849010150 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 1133849010151 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1133849010152 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1133849010153 Walker A/P-loop; other site 1133849010154 ATP binding site [chemical binding]; other site 1133849010155 Q-loop/lid; other site 1133849010156 ABC transporter signature motif; other site 1133849010157 Walker B; other site 1133849010158 D-loop; other site 1133849010159 H-loop/switch region; other site 1133849010160 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1133849010161 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1133849010162 Walker A/P-loop; other site 1133849010163 ATP binding site [chemical binding]; other site 1133849010164 Q-loop/lid; other site 1133849010165 ABC transporter signature motif; other site 1133849010166 Walker B; other site 1133849010167 D-loop; other site 1133849010168 H-loop/switch region; other site 1133849010169 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1133849010170 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1133849010171 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1133849010172 putative dimer interface [polypeptide binding]; other site 1133849010173 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1133849010174 Isochorismatase family; Region: Isochorismatase; pfam00857 1133849010175 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1133849010176 catalytic triad [active] 1133849010177 conserved cis-peptide bond; other site 1133849010178 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 1133849010179 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 1133849010180 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1133849010181 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849010182 Cytochrome P450; Region: p450; cl12078 1133849010183 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1133849010184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849010185 putative substrate translocation pore; other site 1133849010186 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1133849010187 NAD binding site [chemical binding]; other site 1133849010188 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849010189 Cytochrome P450; Region: p450; cl12078 1133849010190 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1133849010191 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1133849010192 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1133849010193 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1133849010194 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849010195 homodimer interface [polypeptide binding]; other site 1133849010196 catalytic residue [active] 1133849010197 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1133849010198 agmatinase; Region: agmatinase; TIGR01230 1133849010199 oligomer interface [polypeptide binding]; other site 1133849010200 putative active site [active] 1133849010201 Mn binding site [ion binding]; other site 1133849010202 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849010203 S-adenosylmethionine binding site [chemical binding]; other site 1133849010204 4-hydroxyphenylacetate 3-hydroxylase N terminal; Region: HpaB_N; pfam11794 1133849010205 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1133849010206 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1133849010207 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1133849010208 active site 1133849010209 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1133849010210 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1133849010211 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1133849010212 putative NADP binding site [chemical binding]; other site 1133849010213 active site 1133849010214 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849010215 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1133849010216 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1133849010217 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1133849010218 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849010219 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849010220 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849010221 active site 1133849010222 FkbH-like domain; Region: FkbH; TIGR01686 1133849010223 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1133849010224 active site 1133849010225 motif I; other site 1133849010226 motif II; other site 1133849010227 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1133849010228 Eukaryotic/archaeal ribosomal protein L31; Region: Ribosomal_L31e; cl00921 1133849010229 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1133849010230 acyl-CoA synthetase; Validated; Region: PRK05850 1133849010231 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1133849010232 acyl-activating enzyme (AAE) consensus motif; other site 1133849010233 active site 1133849010234 benzoate transport; Region: 2A0115; TIGR00895 1133849010235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849010236 putative substrate translocation pore; other site 1133849010237 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 1133849010238 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1133849010239 active site 1133849010240 metal binding site [ion binding]; metal-binding site 1133849010241 C-terminal domain of type I, class II extradiol dioxygenases; catalytic domain; Region: ED_TypeI_classII_C; cd08343 1133849010242 active site 1133849010243 metal binding site [ion binding]; metal-binding site 1133849010244 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 1133849010245 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1133849010246 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1133849010247 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1133849010248 Bacterial transcriptional regulator; Region: IclR; pfam01614 1133849010249 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1133849010250 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1133849010251 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1133849010252 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1133849010253 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1133849010254 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849010255 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849010256 acyl-activating enzyme (AAE) consensus motif; other site 1133849010257 acyl-activating enzyme (AAE) consensus motif; other site 1133849010258 AMP binding site [chemical binding]; other site 1133849010259 active site 1133849010260 CoA binding site [chemical binding]; other site 1133849010261 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849010262 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1133849010263 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1133849010264 putative NAD(P) binding site [chemical binding]; other site 1133849010265 active site 1133849010266 putative substrate binding site [chemical binding]; other site 1133849010267 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1133849010268 Competence-damaged protein; Region: CinA; pfam02464 1133849010269 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1133849010270 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1133849010271 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1133849010272 NAD binding site [chemical binding]; other site 1133849010273 catalytic Zn binding site [ion binding]; other site 1133849010274 structural Zn binding site [ion binding]; other site 1133849010275 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849010276 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1133849010277 hydrophobic ligand binding site; other site 1133849010278 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1133849010279 anti sigma factor interaction site; other site 1133849010280 regulatory phosphorylation site [posttranslational modification]; other site 1133849010281 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1133849010282 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1133849010283 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849010284 catalytic residue [active] 1133849010285 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1133849010286 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1133849010287 Fe-S cluster binding site [ion binding]; other site 1133849010288 active site 1133849010289 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 1133849010290 putative hydrophobic ligand binding site [chemical binding]; other site 1133849010291 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1133849010292 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1133849010293 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1133849010294 minor groove reading motif; other site 1133849010295 carboxylate-amine ligase; Provisional; Region: PRK13517 1133849010296 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1133849010297 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 1133849010298 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 1133849010299 active site 1133849010300 DNA binding site [nucleotide binding] 1133849010301 Int/Topo IB signature motif; other site 1133849010302 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 1133849010303 putative active site; other site 1133849010304 putative metal binding residues [ion binding]; other site 1133849010305 signature motif; other site 1133849010306 putative triphosphate binding site [ion binding]; other site 1133849010307 CHAD domain; Region: CHAD; pfam05235 1133849010308 hypothetical protein; Provisional; Region: PRK07475 1133849010309 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1133849010310 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1133849010311 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1133849010312 short chain dehydrogenase; Provisional; Region: PRK06125 1133849010313 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849010314 active site 1133849010315 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1133849010316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849010317 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1133849010318 putative substrate translocation pore; other site 1133849010319 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1133849010320 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1133849010321 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849010322 catalytic residue [active] 1133849010323 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1133849010324 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1133849010325 E3 interaction surface; other site 1133849010326 lipoyl attachment site [posttranslational modification]; other site 1133849010327 e3 binding domain; Region: E3_binding; pfam02817 1133849010328 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1133849010329 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1133849010330 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1133849010331 alpha subunit interface [polypeptide binding]; other site 1133849010332 TPP binding site [chemical binding]; other site 1133849010333 heterodimer interface [polypeptide binding]; other site 1133849010334 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1133849010335 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1133849010336 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1133849010337 tetramer interface [polypeptide binding]; other site 1133849010338 TPP-binding site [chemical binding]; other site 1133849010339 heterodimer interface [polypeptide binding]; other site 1133849010340 phosphorylation loop region [posttranslational modification] 1133849010341 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1133849010342 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1133849010343 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1133849010344 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1133849010345 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1133849010346 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1133849010347 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849010348 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849010349 DNA binding residues [nucleotide binding] 1133849010350 dimerization interface [polypeptide binding]; other site 1133849010351 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849010352 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1133849010353 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849010354 Walker A/P-loop; other site 1133849010355 ATP binding site [chemical binding]; other site 1133849010356 Q-loop/lid; other site 1133849010357 ABC transporter signature motif; other site 1133849010358 Walker B; other site 1133849010359 D-loop; other site 1133849010360 H-loop/switch region; other site 1133849010361 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1133849010362 Predicted membrane protein [Function unknown]; Region: COG1288 1133849010363 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1133849010364 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1133849010365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849010366 putative substrate translocation pore; other site 1133849010367 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1133849010368 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1133849010369 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1133849010370 dimerization interface [polypeptide binding]; other site 1133849010371 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849010372 dimerization interface [polypeptide binding]; other site 1133849010373 putative DNA binding site [nucleotide binding]; other site 1133849010374 putative Zn2+ binding site [ion binding]; other site 1133849010375 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849010376 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1133849010377 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849010378 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1133849010379 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1133849010380 active site 1133849010381 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 1133849010382 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1133849010383 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1133849010384 active site 1133849010385 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1133849010386 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1133849010387 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1133849010388 putative NADP binding site [chemical binding]; other site 1133849010389 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1133849010390 active site 1133849010391 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1133849010392 thioester reductase domain; Region: Thioester-redct; TIGR01746 1133849010393 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849010394 NAD(P) binding site [chemical binding]; other site 1133849010395 active site 1133849010396 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1133849010397 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1133849010398 active site 1133849010399 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1133849010400 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1133849010401 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1133849010402 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1133849010403 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1133849010404 NAD(P) binding site [chemical binding]; other site 1133849010405 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1133849010406 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849010407 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1133849010408 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849010409 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1133849010410 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1133849010411 conserved cys residue [active] 1133849010412 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849010413 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1133849010414 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1133849010415 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849010416 catalytic residue [active] 1133849010417 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849010418 Cytochrome P450; Region: p450; cl12078 1133849010419 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1133849010420 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1133849010421 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1133849010422 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1133849010423 dimer interface [polypeptide binding]; other site 1133849010424 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1133849010425 active site 1133849010426 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1133849010427 Ligand Binding Site [chemical binding]; other site 1133849010428 Molecular Tunnel; other site 1133849010429 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1133849010430 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849010431 catalytic residue [active] 1133849010432 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849010433 Cytochrome P450; Region: p450; cl12078 1133849010434 CAAX protease self-immunity; Region: Abi; pfam02517 1133849010435 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849010436 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1133849010437 NAD(P) binding site [chemical binding]; other site 1133849010438 active site 1133849010439 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR8; cd08273 1133849010440 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1133849010441 putative NAD(P) binding site [chemical binding]; other site 1133849010442 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849010443 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849010444 WHG domain; Region: WHG; pfam13305 1133849010445 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1133849010446 Walker A motif; other site 1133849010447 ATP binding site [chemical binding]; other site 1133849010448 Walker B motif; other site 1133849010449 arginine finger; other site 1133849010450 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 1133849010451 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1133849010452 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1133849010453 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1133849010454 DNA binding residues [nucleotide binding] 1133849010455 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1133849010456 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1133849010457 putative dimer interface [polypeptide binding]; other site 1133849010458 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1133849010459 anti sigma factor interaction site; other site 1133849010460 regulatory phosphorylation site [posttranslational modification]; other site 1133849010461 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1133849010462 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1133849010463 putative NAD(P) binding site [chemical binding]; other site 1133849010464 short chain dehydrogenase; Provisional; Region: PRK08263 1133849010465 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1133849010466 NADP binding site [chemical binding]; other site 1133849010467 active site 1133849010468 steroid binding site; other site 1133849010469 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849010470 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849010471 WHG domain; Region: WHG; pfam13305 1133849010472 amidase; Provisional; Region: PRK07869 1133849010473 Amidase; Region: Amidase; cl11426 1133849010474 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1133849010475 ABC1 family; Region: ABC1; pfam03109 1133849010476 serine/threonine protein kinase; Provisional; Region: PRK14879 1133849010477 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 1133849010478 putative catalytic residues [active] 1133849010479 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849010480 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849010481 short chain dehydrogenase; Provisional; Region: PRK08267 1133849010482 classical (c) SDRs; Region: SDR_c; cd05233 1133849010483 NAD(P) binding site [chemical binding]; other site 1133849010484 active site 1133849010485 classical (c) SDRs; Region: SDR_c; cd05233 1133849010486 NAD(P) binding site [chemical binding]; other site 1133849010487 active site 1133849010488 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1133849010489 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1133849010490 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1133849010491 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1133849010492 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1133849010493 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1133849010494 putative hydrophobic ligand binding site [chemical binding]; other site 1133849010495 protein interface [polypeptide binding]; other site 1133849010496 gate; other site 1133849010497 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1133849010498 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1133849010499 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1133849010500 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1133849010501 active site 1133849010502 active site 1133849010503 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1133849010504 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1133849010505 transmembrane helices; other site 1133849010506 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1133849010507 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1133849010508 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1133849010509 Histidine kinase; Region: HisKA_3; pfam07730 1133849010510 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849010511 ATP binding site [chemical binding]; other site 1133849010512 Mg2+ binding site [ion binding]; other site 1133849010513 G-X-G motif; other site 1133849010514 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849010515 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849010516 active site 1133849010517 phosphorylation site [posttranslational modification] 1133849010518 intermolecular recognition site; other site 1133849010519 dimerization interface [polypeptide binding]; other site 1133849010520 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849010521 DNA binding residues [nucleotide binding] 1133849010522 dimerization interface [polypeptide binding]; other site 1133849010523 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 1133849010524 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1133849010525 ATP binding site [chemical binding]; other site 1133849010526 putative Mg++ binding site [ion binding]; other site 1133849010527 Helicase associated domain (HA2); Region: HA2; pfam04408 1133849010528 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1133849010529 SnoaL-like domain; Region: SnoaL_4; pfam13577 1133849010530 SnoaL-like domain; Region: SnoaL_3; pfam13474 1133849010531 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1133849010532 Predicted flavoprotein [General function prediction only]; Region: COG0431 1133849010533 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849010534 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1133849010535 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1133849010536 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 1133849010537 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1133849010538 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1133849010539 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1133849010540 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 1133849010541 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 1133849010542 putative active site [active] 1133849010543 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1133849010544 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1133849010545 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1133849010546 Uncharacterized conserved protein [Function unknown]; Region: COG5276 1133849010547 Domain of unknown function DUF21; Region: DUF21; pfam01595 1133849010548 FOG: CBS domain [General function prediction only]; Region: COG0517 1133849010549 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1133849010550 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1133849010551 Domain of unknown function DUF21; Region: DUF21; pfam01595 1133849010552 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1133849010553 Transporter associated domain; Region: CorC_HlyC; smart01091 1133849010554 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1133849010555 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 1133849010556 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1133849010557 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1133849010558 active site 1133849010559 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1133849010560 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1133849010561 ATP binding site [chemical binding]; other site 1133849010562 Mg++ binding site [ion binding]; other site 1133849010563 motif III; other site 1133849010564 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1133849010565 nucleotide binding region [chemical binding]; other site 1133849010566 ATP-binding site [chemical binding]; other site 1133849010567 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1133849010568 Penicillinase repressor; Region: Pencillinase_R; cl17580 1133849010569 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1133849010570 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1133849010571 Walker A/P-loop; other site 1133849010572 ATP binding site [chemical binding]; other site 1133849010573 Q-loop/lid; other site 1133849010574 ABC transporter signature motif; other site 1133849010575 Walker B; other site 1133849010576 D-loop; other site 1133849010577 H-loop/switch region; other site 1133849010578 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1133849010579 dimer interface [polypeptide binding]; other site 1133849010580 putative PBP binding regions; other site 1133849010581 ABC-ATPase subunit interface; other site 1133849010582 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1133849010583 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1133849010584 dimer interface [polypeptide binding]; other site 1133849010585 putative PBP binding regions; other site 1133849010586 ABC-ATPase subunit interface; other site 1133849010587 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 1133849010588 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 1133849010589 active site 1133849010590 zinc binding site [ion binding]; other site 1133849010591 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1133849010592 CoenzymeA binding site [chemical binding]; other site 1133849010593 subunit interaction site [polypeptide binding]; other site 1133849010594 PHB binding site; other site 1133849010595 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1133849010596 alpha-gamma subunit interface [polypeptide binding]; other site 1133849010597 beta-gamma subunit interface [polypeptide binding]; other site 1133849010598 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1133849010599 gamma-beta subunit interface [polypeptide binding]; other site 1133849010600 alpha-beta subunit interface [polypeptide binding]; other site 1133849010601 urease subunit alpha; Reviewed; Region: ureC; PRK13206 1133849010602 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1133849010603 subunit interactions [polypeptide binding]; other site 1133849010604 active site 1133849010605 flap region; other site 1133849010606 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 1133849010607 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1133849010608 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849010609 putative DNA binding site [nucleotide binding]; other site 1133849010610 putative Zn2+ binding site [ion binding]; other site 1133849010611 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1133849010612 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 1133849010613 oligomer interface [polypeptide binding]; other site 1133849010614 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849010615 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849010616 short chain dehydrogenase; Provisional; Region: PRK05650 1133849010617 classical (c) SDRs; Region: SDR_c; cd05233 1133849010618 NAD(P) binding site [chemical binding]; other site 1133849010619 active site 1133849010620 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1133849010621 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1133849010622 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1133849010623 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1133849010624 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1133849010625 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1133849010626 protein binding site [polypeptide binding]; other site 1133849010627 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1133849010628 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1133849010629 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1133849010630 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1133849010631 heterodimer interface [polypeptide binding]; other site 1133849010632 substrate interaction site [chemical binding]; other site 1133849010633 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1133849010634 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1133849010635 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1133849010636 active site 1133849010637 substrate binding site [chemical binding]; other site 1133849010638 coenzyme B12 binding site [chemical binding]; other site 1133849010639 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1133849010640 B12 binding site [chemical binding]; other site 1133849010641 cobalt ligand [ion binding]; other site 1133849010642 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1133849010643 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1133849010644 Walker A; other site 1133849010645 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1133849010646 oligomeric interface; other site 1133849010647 putative active site [active] 1133849010648 homodimer interface [polypeptide binding]; other site 1133849010649 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1133849010650 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1133849010651 MarR family; Region: MarR; pfam01047 1133849010652 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1133849010653 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1133849010654 NAD binding site [chemical binding]; other site 1133849010655 substrate binding site [chemical binding]; other site 1133849010656 putative active site [active] 1133849010657 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1133849010658 active site 1133849010659 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 1133849010660 active site 1133849010661 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1133849010662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849010663 putative substrate translocation pore; other site 1133849010664 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1133849010665 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1133849010666 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1133849010667 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 1133849010668 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849010669 NAD(P) binding site [chemical binding]; other site 1133849010670 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849010671 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1133849010672 active site 1133849010673 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1133849010674 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1133849010675 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849010676 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849010677 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849010678 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849010679 active site 1133849010680 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849010681 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849010682 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 1133849010683 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1133849010684 nucleotide binding site [chemical binding]; other site 1133849010685 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 1133849010686 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 1133849010687 active site 1133849010688 DNA binding site [nucleotide binding] 1133849010689 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 1133849010690 DNA binding site [nucleotide binding] 1133849010691 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1133849010692 DNA-binding site [nucleotide binding]; DNA binding site 1133849010693 RNA-binding motif; other site 1133849010694 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1133849010695 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849010696 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1133849010697 TPR motif; other site 1133849010698 binding surface 1133849010699 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849010700 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1133849010701 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849010702 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1133849010703 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849010704 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1133849010705 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849010706 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849010707 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849010708 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1133849010709 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1133849010710 putative active site [active] 1133849010711 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1133849010712 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1133849010713 Walker A/P-loop; other site 1133849010714 ATP binding site [chemical binding]; other site 1133849010715 Q-loop/lid; other site 1133849010716 ABC transporter signature motif; other site 1133849010717 Walker B; other site 1133849010718 D-loop; other site 1133849010719 H-loop/switch region; other site 1133849010720 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 1133849010721 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 1133849010722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849010723 dimer interface [polypeptide binding]; other site 1133849010724 conserved gate region; other site 1133849010725 putative PBP binding loops; other site 1133849010726 ABC-ATPase subunit interface; other site 1133849010727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849010728 dimer interface [polypeptide binding]; other site 1133849010729 conserved gate region; other site 1133849010730 putative PBP binding loops; other site 1133849010731 ABC-ATPase subunit interface; other site 1133849010732 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1133849010733 MgtC family; Region: MgtC; pfam02308 1133849010734 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849010735 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849010736 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1133849010737 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1133849010738 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849010739 catalytic residue [active] 1133849010740 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1133849010741 active site residue [active] 1133849010742 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1133849010743 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842 1133849010744 dimer interface [polypeptide binding]; other site 1133849010745 active site 1133849010746 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1133849010747 catalytic residues [active] 1133849010748 substrate binding site [chemical binding]; other site 1133849010749 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1133849010750 metal-binding site [ion binding] 1133849010751 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1133849010752 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1133849010753 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849010754 catalytic residue [active] 1133849010755 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1133849010756 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1133849010757 FOG: CBS domain [General function prediction only]; Region: COG0517 1133849010758 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1133849010759 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1133849010760 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849010761 non-specific DNA binding site [nucleotide binding]; other site 1133849010762 salt bridge; other site 1133849010763 sequence-specific DNA binding site [nucleotide binding]; other site 1133849010764 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1133849010765 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1133849010766 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1133849010767 NAD(P) binding site [chemical binding]; other site 1133849010768 putative active site [active] 1133849010769 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 1133849010770 Secretory lipase; Region: LIP; pfam03583 1133849010771 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1133849010772 Secretory lipase; Region: LIP; pfam03583 1133849010773 Secretory lipase; Region: LIP; pfam03583 1133849010774 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1133849010775 active site 1133849010776 catalytic site [active] 1133849010777 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1133849010778 active site 1133849010779 catalytic site [active] 1133849010780 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1133849010781 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849010782 non-specific DNA binding site [nucleotide binding]; other site 1133849010783 salt bridge; other site 1133849010784 sequence-specific DNA binding site [nucleotide binding]; other site 1133849010785 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1133849010786 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849010787 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1133849010788 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1133849010789 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1133849010790 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 1133849010791 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 1133849010792 homodimer interface [polypeptide binding]; other site 1133849010793 putative substrate binding pocket [chemical binding]; other site 1133849010794 diiron center [ion binding]; other site 1133849010795 Predicted esterase [General function prediction only]; Region: COG0627 1133849010796 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1133849010797 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1133849010798 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1133849010799 active site 1133849010800 catalytic site [active] 1133849010801 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1133849010802 active site 2 [active] 1133849010803 active site 1 [active] 1133849010804 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1133849010805 Lipase (class 2); Region: Lipase_2; pfam01674 1133849010806 Lipase (class 2); Region: Lipase_2; pfam01674 1133849010807 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1133849010808 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1133849010809 ATP binding site [chemical binding]; other site 1133849010810 substrate interface [chemical binding]; other site 1133849010811 SnoaL-like domain; Region: SnoaL_4; pfam13577 1133849010812 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849010813 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849010814 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 1133849010815 DNA binding residues [nucleotide binding] 1133849010816 dimerization interface [polypeptide binding]; other site 1133849010817 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1133849010818 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1133849010819 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1133849010820 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1133849010821 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849010822 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1133849010823 DoxX-like family; Region: DoxX_2; pfam13564 1133849010824 choline dehydrogenase; Validated; Region: PRK02106 1133849010825 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1133849010826 hypothetical protein; Validated; Region: PRK07121 1133849010827 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1133849010828 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1133849010829 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1133849010830 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1133849010831 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1133849010832 short chain dehydrogenase; Provisional; Region: PRK07774 1133849010833 classical (c) SDRs; Region: SDR_c; cd05233 1133849010834 NAD(P) binding site [chemical binding]; other site 1133849010835 active site 1133849010836 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 1133849010837 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1133849010838 NAD binding site [chemical binding]; other site 1133849010839 catalytic residues [active] 1133849010840 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849010841 Cytochrome P450; Region: p450; cl12078 1133849010842 short chain dehydrogenase; Provisional; Region: PRK07775 1133849010843 classical (c) SDRs; Region: SDR_c; cd05233 1133849010844 NAD(P) binding site [chemical binding]; other site 1133849010845 active site 1133849010846 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1133849010847 acyl-CoA synthetase; Validated; Region: PRK07798 1133849010848 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849010849 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 1133849010850 acyl-activating enzyme (AAE) consensus motif; other site 1133849010851 putative AMP binding site [chemical binding]; other site 1133849010852 putative active site [active] 1133849010853 putative CoA binding site [chemical binding]; other site 1133849010854 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 1133849010855 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 1133849010856 NAD(P) binding site [chemical binding]; other site 1133849010857 catalytic residues [active] 1133849010858 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849010859 Cytochrome P450; Region: p450; cl12078 1133849010860 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1133849010861 catalytic residues [active] 1133849010862 dimer interface [polypeptide binding]; other site 1133849010863 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849010864 Cytochrome P450; Region: p450; cl12078 1133849010865 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1133849010866 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1133849010867 active site 1133849010868 non-prolyl cis peptide bond; other site 1133849010869 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1133849010870 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1133849010871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849010872 putative substrate translocation pore; other site 1133849010873 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1133849010874 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849010875 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849010876 acyl-activating enzyme (AAE) consensus motif; other site 1133849010877 acyl-activating enzyme (AAE) consensus motif; other site 1133849010878 AMP binding site [chemical binding]; other site 1133849010879 active site 1133849010880 CoA binding site [chemical binding]; other site 1133849010881 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849010882 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1133849010883 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1133849010884 putative NAD(P) binding site [chemical binding]; other site 1133849010885 active site 1133849010886 putative substrate binding site [chemical binding]; other site 1133849010887 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1133849010888 Helix-turn-helix domain; Region: HTH_31; pfam13560 1133849010889 Tropomyosin; Region: Tropomyosin; pfam00261 1133849010890 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 1133849010891 Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051 1133849010892 Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051 1133849010893 active site 1133849010894 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 1133849010895 conformational flexibility of ligand binding pocket; other site 1133849010896 ADP-ribosylating toxin turn-turn motif; other site 1133849010897 Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051 1133849010898 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 1133849010899 active site 1133849010900 ADP-ribosylating toxin turn-turn motif; other site 1133849010901 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 1133849010902 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1133849010903 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 1133849010904 T-complex protein 10 C-terminus; Region: Tcp10_C; pfam07202 1133849010905 T-complex protein 10 C-terminus; Region: Tcp10_C; pfam07202 1133849010906 T-complex protein 10 C-terminus; Region: Tcp10_C; pfam07202 1133849010907 EspG family; Region: ESX-1_EspG; pfam14011 1133849010908 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1133849010909 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1133849010910 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1133849010911 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1133849010912 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1133849010913 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 1133849010914 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1133849010915 MMPL family; Region: MMPL; pfam03176 1133849010916 MMPL family; Region: MMPL; pfam03176 1133849010917 Domain of unknown function (DUF385); Region: DUF385; cl04387 1133849010918 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 1133849010919 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1133849010920 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1133849010921 molybdopterin cofactor binding site [chemical binding]; other site 1133849010922 substrate binding site [chemical binding]; other site 1133849010923 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1133849010924 molybdopterin cofactor binding site; other site 1133849010925 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1133849010926 CGNR zinc finger; Region: zf-CGNR; pfam11706 1133849010927 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1133849010928 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849010929 LGFP repeat; Region: LGFP; pfam08310 1133849010930 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1133849010931 active site 1133849010932 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1133849010933 active site 1133849010934 metal binding site [ion binding]; metal-binding site 1133849010935 LexA repressor; Validated; Region: PRK00215 1133849010936 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1133849010937 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1133849010938 Catalytic site [active] 1133849010939 NAD-dependent deacetylase; Provisional; Region: PRK05333 1133849010940 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1133849010941 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849010942 dimerization interface [polypeptide binding]; other site 1133849010943 putative DNA binding site [nucleotide binding]; other site 1133849010944 putative Zn2+ binding site [ion binding]; other site 1133849010945 short chain dehydrogenase; Provisional; Region: PRK06523 1133849010946 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849010947 NAD(P) binding site [chemical binding]; other site 1133849010948 active site 1133849010949 aminotransferase AlaT; Validated; Region: PRK09265 1133849010950 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1133849010951 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849010952 homodimer interface [polypeptide binding]; other site 1133849010953 catalytic residue [active] 1133849010954 Predicted transcriptional regulators [Transcription]; Region: COG1733 1133849010955 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1133849010956 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1133849010957 TAP-like protein; Region: Abhydrolase_4; pfam08386 1133849010958 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1133849010959 Part of AAA domain; Region: AAA_19; pfam13245 1133849010960 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1133849010961 active site 1133849010962 TDP-binding site; other site 1133849010963 acceptor substrate-binding pocket; other site 1133849010964 homodimer interface [polypeptide binding]; other site 1133849010965 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1133849010966 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1133849010967 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849010968 putative DNA binding site [nucleotide binding]; other site 1133849010969 putative Zn2+ binding site [ion binding]; other site 1133849010970 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 1133849010971 putative hydrophobic ligand binding site [chemical binding]; other site 1133849010972 CLM binding site; other site 1133849010973 L1 loop; other site 1133849010974 DNA binding site [nucleotide binding] 1133849010975 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1133849010976 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 1133849010977 active site 1133849010978 DNA binding site [nucleotide binding] 1133849010979 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1133849010980 DNA binding site [nucleotide binding] 1133849010981 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1133849010982 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1133849010983 rRNA binding site [nucleotide binding]; other site 1133849010984 predicted 30S ribosome binding site; other site 1133849010985 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1133849010986 active site 1133849010987 DNA binding site [nucleotide binding] 1133849010988 Int/Topo IB signature motif; other site 1133849010989 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1133849010990 metal binding triad [ion binding]; metal-binding site 1133849010991 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 1133849010992 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1133849010993 Helix-turn-helix domain; Region: HTH_17; pfam12728 1133849010994 Citrate synthase; Region: Citrate_synt; pfam00285 1133849010995 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1133849010996 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1133849010997 citrylCoA binding site [chemical binding]; other site 1133849010998 oxalacetate binding site [chemical binding]; other site 1133849010999 coenzyme A binding site [chemical binding]; other site 1133849011000 catalytic triad [active] 1133849011001 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1133849011002 Citrate synthase; Region: Citrate_synt; pfam00285 1133849011003 oxalacetate binding site [chemical binding]; other site 1133849011004 citrylCoA binding site [chemical binding]; other site 1133849011005 coenzyme A binding site [chemical binding]; other site 1133849011006 catalytic triad [active] 1133849011007 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1133849011008 MarR family; Region: MarR; pfam01047 1133849011009 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849011010 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 1133849011011 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1133849011012 DinB superfamily; Region: DinB_2; pfam12867 1133849011013 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1133849011014 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1133849011015 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1133849011016 dimerization interface [polypeptide binding]; other site 1133849011017 short chain dehydrogenase; Provisional; Region: PRK06500 1133849011018 classical (c) SDRs; Region: SDR_c; cd05233 1133849011019 NAD(P) binding site [chemical binding]; other site 1133849011020 active site 1133849011021 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 1133849011022 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849011023 NAD(P) binding site [chemical binding]; other site 1133849011024 active site 1133849011025 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849011026 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849011027 hypothetical protein; Provisional; Region: PRK07236 1133849011028 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1133849011029 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1133849011030 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1133849011031 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 1133849011032 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1133849011033 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1133849011034 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1133849011035 dimerization interface [polypeptide binding]; other site 1133849011036 substrate binding pocket [chemical binding]; other site 1133849011037 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 1133849011038 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1133849011039 Coenzyme A binding pocket [chemical binding]; other site 1133849011040 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1133849011041 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1133849011042 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1133849011043 amidase; Provisional; Region: PRK06170 1133849011044 Amidase; Region: Amidase; cl11426 1133849011045 active site 1133849011046 metal binding site [ion binding]; metal-binding site 1133849011047 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1133849011048 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1133849011049 glycogen branching enzyme; Provisional; Region: PRK14705 1133849011050 Short repeat of unknown function (DUF308); Region: DUF308; pfam03729 1133849011051 Predicted membrane protein [Function unknown]; Region: COG2311 1133849011052 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1133849011053 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 1133849011054 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849011055 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849011056 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1133849011057 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1133849011058 active site 1133849011059 catalytic tetrad [active] 1133849011060 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849011061 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849011062 WHG domain; Region: WHG; pfam13305 1133849011063 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1133849011064 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1133849011065 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1133849011066 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1133849011067 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1133849011068 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1133849011069 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1133849011070 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1133849011071 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1133849011072 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1133849011073 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1133849011074 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1133849011075 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1133849011076 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1133849011077 4Fe-4S binding domain; Region: Fer4; pfam00037 1133849011078 4Fe-4S binding domain; Region: Fer4; pfam00037 1133849011079 NADH dehydrogenase subunit G; Validated; Region: PRK07860 1133849011080 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1133849011081 catalytic loop [active] 1133849011082 iron binding site [ion binding]; other site 1133849011083 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1133849011084 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1133849011085 molybdopterin cofactor binding site; other site 1133849011086 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1133849011087 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1133849011088 SLBB domain; Region: SLBB; pfam10531 1133849011089 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1133849011090 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1133849011091 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1133849011092 putative dimer interface [polypeptide binding]; other site 1133849011093 [2Fe-2S] cluster binding site [ion binding]; other site 1133849011094 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1133849011095 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 1133849011096 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 1133849011097 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1133849011098 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1133849011099 NADH dehydrogenase subunit A; Validated; Region: PRK07928 1133849011100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1133849011101 active site 1133849011102 phosphorylation site [posttranslational modification] 1133849011103 intermolecular recognition site; other site 1133849011104 dimerization interface [polypeptide binding]; other site 1133849011105 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1133849011106 phosphopeptide binding site; other site 1133849011107 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1133849011108 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1133849011109 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1133849011110 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1133849011111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849011112 H+ Antiporter protein; Region: 2A0121; TIGR00900 1133849011113 putative substrate translocation pore; other site 1133849011114 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1133849011115 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1133849011116 substrate binding site [chemical binding]; other site 1133849011117 oxyanion hole (OAH) forming residues; other site 1133849011118 trimer interface [polypeptide binding]; other site 1133849011119 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849011120 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849011121 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1133849011122 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 1133849011123 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849011124 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849011125 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849011126 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1133849011127 hypothetical protein; Provisional; Region: PRK06834 1133849011128 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1133849011129 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 1133849011130 putative [Fe4-S4] binding site [ion binding]; other site 1133849011131 putative molybdopterin cofactor binding site [chemical binding]; other site 1133849011132 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1133849011133 putative molybdopterin cofactor binding site; other site 1133849011134 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1133849011135 active site 1133849011136 catalytic triad [active] 1133849011137 oxyanion hole [active] 1133849011138 Predicted membrane protein [Function unknown]; Region: COG2364 1133849011139 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1133849011140 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 1133849011141 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1133849011142 putative hydrophobic ligand binding site [chemical binding]; other site 1133849011143 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849011144 dimerization interface [polypeptide binding]; other site 1133849011145 putative DNA binding site [nucleotide binding]; other site 1133849011146 putative Zn2+ binding site [ion binding]; other site 1133849011147 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1133849011148 hydrophobic ligand binding site; other site 1133849011149 Protein kinase domain; Region: Pkinase; pfam00069 1133849011150 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1133849011151 active site 1133849011152 ATP binding site [chemical binding]; other site 1133849011153 substrate binding site [chemical binding]; other site 1133849011154 activation loop (A-loop); other site 1133849011155 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1133849011156 YWTD domain; Region: YWTD; cl17223 1133849011157 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1133849011158 Strictosidine synthase; Region: Str_synth; pfam03088 1133849011159 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849011160 PGAP1-like protein; Region: PGAP1; pfam07819 1133849011161 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 1133849011162 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 1133849011163 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1133849011164 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849011165 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 1133849011166 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849011167 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1133849011168 dimer interface [polypeptide binding]; other site 1133849011169 substrate binding site [chemical binding]; other site 1133849011170 metal binding site [ion binding]; metal-binding site 1133849011171 hypothetical protein; Validated; Region: PRK07121 1133849011172 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1133849011173 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1133849011174 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1133849011175 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 1133849011176 putative dimer interface [polypeptide binding]; other site 1133849011177 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1133849011178 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849011179 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849011180 active site 1133849011181 phosphorylation site [posttranslational modification] 1133849011182 intermolecular recognition site; other site 1133849011183 dimerization interface [polypeptide binding]; other site 1133849011184 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849011185 DNA binding residues [nucleotide binding] 1133849011186 dimerization interface [polypeptide binding]; other site 1133849011187 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1133849011188 Histidine kinase; Region: HisKA_3; pfam07730 1133849011189 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 1133849011190 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1133849011191 active site 1133849011192 HIGH motif; other site 1133849011193 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1133849011194 active site 1133849011195 KMSKS motif; other site 1133849011196 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 1133849011197 putative tRNA binding surface [nucleotide binding]; other site 1133849011198 conserved hypothetical protein; Region: TIGR03843 1133849011199 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 1133849011200 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1133849011201 catalytic core [active] 1133849011202 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 1133849011203 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1133849011204 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1133849011205 active site 1133849011206 catalytic tetrad [active] 1133849011207 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 1133849011208 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1133849011209 intersubunit interface [polypeptide binding]; other site 1133849011210 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1133849011211 dimer interface [polypeptide binding]; other site 1133849011212 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1133849011213 putative PBP binding regions; other site 1133849011214 ABC-ATPase subunit interface; other site 1133849011215 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1133849011216 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1133849011217 Walker A/P-loop; other site 1133849011218 ATP binding site [chemical binding]; other site 1133849011219 Q-loop/lid; other site 1133849011220 ABC transporter signature motif; other site 1133849011221 Walker B; other site 1133849011222 D-loop; other site 1133849011223 H-loop/switch region; other site 1133849011224 Phosphotransferase enzyme family; Region: APH; pfam01636 1133849011225 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1133849011226 substrate binding site [chemical binding]; other site 1133849011227 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1133849011228 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 1133849011229 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1133849011230 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 1133849011231 MMPL family; Region: MMPL; pfam03176 1133849011232 MMPL family; Region: MMPL; pfam03176 1133849011233 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1133849011234 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1133849011235 quinone interaction residues [chemical binding]; other site 1133849011236 active site 1133849011237 catalytic residues [active] 1133849011238 FMN binding site [chemical binding]; other site 1133849011239 substrate binding site [chemical binding]; other site 1133849011240 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1133849011241 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1133849011242 substrate binding site [chemical binding]; other site 1133849011243 ATP binding site [chemical binding]; other site 1133849011244 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 1133849011245 dimerization interface [polypeptide binding]; other site 1133849011246 active site 1133849011247 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 1133849011248 dimerization interface [polypeptide binding]; other site 1133849011249 active site 1133849011250 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1133849011251 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1133849011252 acyl-activating enzyme (AAE) consensus motif; other site 1133849011253 putative AMP binding site [chemical binding]; other site 1133849011254 putative active site [active] 1133849011255 putative CoA binding site [chemical binding]; other site 1133849011256 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1133849011257 substrate binding site [chemical binding]; other site 1133849011258 hypothetical protein; Provisional; Region: PRK07906 1133849011259 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1133849011260 putative metal binding site [ion binding]; other site 1133849011261 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1133849011262 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1133849011263 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849011264 homodimer interface [polypeptide binding]; other site 1133849011265 catalytic residue [active] 1133849011266 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1133849011267 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1133849011268 putative DNA binding site [nucleotide binding]; other site 1133849011269 putative Zn2+ binding site [ion binding]; other site 1133849011270 AsnC family; Region: AsnC_trans_reg; pfam01037 1133849011271 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1133849011272 active site 1133849011273 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1133849011274 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1133849011275 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849011276 putative substrate translocation pore; other site 1133849011277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849011278 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1133849011279 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1133849011280 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1133849011281 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849011282 active site 1133849011283 phosphorylation site [posttranslational modification] 1133849011284 intermolecular recognition site; other site 1133849011285 dimerization interface [polypeptide binding]; other site 1133849011286 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1133849011287 DNA binding site [nucleotide binding] 1133849011288 hypothetical protein; Provisional; Region: PRK07236 1133849011289 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1133849011290 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1133849011291 Condensation domain; Region: Condensation; pfam00668 1133849011292 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849011293 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849011294 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849011295 acyl-activating enzyme (AAE) consensus motif; other site 1133849011296 AMP binding site [chemical binding]; other site 1133849011297 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849011298 thioester reductase domain; Region: Thioester-redct; TIGR01746 1133849011299 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1133849011300 putative NAD(P) binding site [chemical binding]; other site 1133849011301 active site 1133849011302 putative substrate binding site [chemical binding]; other site 1133849011303 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849011304 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1133849011305 acyl-activating enzyme (AAE) consensus motif; other site 1133849011306 AMP binding site [chemical binding]; other site 1133849011307 active site 1133849011308 CoA binding site [chemical binding]; other site 1133849011309 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849011310 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1133849011311 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 1133849011312 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849011313 S-adenosylmethionine binding site [chemical binding]; other site 1133849011314 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 1133849011315 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1133849011316 kynureninase; Region: kynureninase; TIGR01814 1133849011317 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849011318 catalytic residue [active] 1133849011319 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 1133849011320 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1133849011321 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1133849011322 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849011323 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1133849011324 active site 1133849011325 metal binding site [ion binding]; metal-binding site 1133849011326 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1133849011327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849011328 putative substrate translocation pore; other site 1133849011329 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849011330 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1133849011331 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849011332 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1133849011333 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1133849011334 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849011335 putative DNA binding site [nucleotide binding]; other site 1133849011336 putative Zn2+ binding site [ion binding]; other site 1133849011337 cytokinin dehydrogenase; Region: PLN02441 1133849011338 FAD binding domain; Region: FAD_binding_4; pfam01565 1133849011339 Cytokinin dehydrogenase 1, FAD and cytokinin binding; Region: Cytokin-bind; pfam09265 1133849011340 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1133849011341 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1133849011342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849011343 S-adenosylmethionine binding site [chemical binding]; other site 1133849011344 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849011345 Cytochrome P450; Region: p450; cl12078 1133849011346 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1133849011347 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 1133849011348 putative NAD(P) binding site [chemical binding]; other site 1133849011349 catalytic Zn binding site [ion binding]; other site 1133849011350 structural Zn binding site [ion binding]; other site 1133849011351 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1133849011352 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1133849011353 NAD(P) binding site [chemical binding]; other site 1133849011354 catalytic residues [active] 1133849011355 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1133849011356 active site 1133849011357 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1133849011358 dimer interface [polypeptide binding]; other site 1133849011359 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1133849011360 Ligand Binding Site [chemical binding]; other site 1133849011361 Molecular Tunnel; other site 1133849011362 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849011363 Walker A/P-loop; other site 1133849011364 ATP binding site [chemical binding]; other site 1133849011365 Q-loop/lid; other site 1133849011366 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1133849011367 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849011368 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1133849011369 Walker A/P-loop; other site 1133849011370 ATP binding site [chemical binding]; other site 1133849011371 Q-loop/lid; other site 1133849011372 ABC transporter signature motif; other site 1133849011373 Walker B; other site 1133849011374 D-loop; other site 1133849011375 H-loop/switch region; other site 1133849011376 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 1133849011377 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1133849011378 Predicted membrane protein [Function unknown]; Region: COG2259 1133849011379 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1133849011380 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1133849011381 putative active site [active] 1133849011382 metal binding site [ion binding]; metal-binding site 1133849011383 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1133849011384 MarR family; Region: MarR; pfam01047 1133849011385 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1133849011386 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1133849011387 active site 1133849011388 catalytic tetrad [active] 1133849011389 CAAX protease self-immunity; Region: Abi; pfam02517 1133849011390 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1133849011391 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1133849011392 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1133849011393 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1133849011394 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1133849011395 Walker A/P-loop; other site 1133849011396 ATP binding site [chemical binding]; other site 1133849011397 Q-loop/lid; other site 1133849011398 ABC transporter signature motif; other site 1133849011399 Walker B; other site 1133849011400 D-loop; other site 1133849011401 H-loop/switch region; other site 1133849011402 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1133849011403 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849011404 dimer interface [polypeptide binding]; other site 1133849011405 conserved gate region; other site 1133849011406 putative PBP binding loops; other site 1133849011407 ABC-ATPase subunit interface; other site 1133849011408 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1133849011409 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1133849011410 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1133849011411 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1133849011412 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1133849011413 TIGR03086 family protein; Region: TIGR03086 1133849011414 peptide synthase; Provisional; Region: PRK12467 1133849011415 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849011416 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849011417 acyl-activating enzyme (AAE) consensus motif; other site 1133849011418 AMP binding site [chemical binding]; other site 1133849011419 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849011420 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849011421 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849011422 acyl-activating enzyme (AAE) consensus motif; other site 1133849011423 AMP binding site [chemical binding]; other site 1133849011424 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849011425 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1133849011426 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849011427 acyl-activating enzyme (AAE) consensus motif; other site 1133849011428 AMP binding site [chemical binding]; other site 1133849011429 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849011430 Condensation domain; Region: Condensation; pfam00668 1133849011431 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1133849011432 Condensation domain; Region: Condensation; pfam00668 1133849011433 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849011434 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1133849011435 acyl-activating enzyme (AAE) consensus motif; other site 1133849011436 AMP binding site [chemical binding]; other site 1133849011437 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849011438 Condensation domain; Region: Condensation; pfam00668 1133849011439 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849011440 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849011441 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849011442 acyl-activating enzyme (AAE) consensus motif; other site 1133849011443 AMP binding site [chemical binding]; other site 1133849011444 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849011445 S-adenosylmethionine binding site [chemical binding]; other site 1133849011446 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849011447 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849011448 Thioesterase domain; Region: Thioesterase; pfam00975 1133849011449 Condensation domain; Region: Condensation; pfam00668 1133849011450 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849011451 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1133849011452 acyl-activating enzyme (AAE) consensus motif; other site 1133849011453 AMP binding site [chemical binding]; other site 1133849011454 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849011455 Condensation domain; Region: Condensation; pfam00668 1133849011456 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849011457 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849011458 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849011459 acyl-activating enzyme (AAE) consensus motif; other site 1133849011460 AMP binding site [chemical binding]; other site 1133849011461 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849011462 Condensation domain; Region: Condensation; pfam00668 1133849011463 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849011464 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849011465 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849011466 acyl-activating enzyme (AAE) consensus motif; other site 1133849011467 AMP binding site [chemical binding]; other site 1133849011468 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1133849011469 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849011470 S-adenosylmethionine binding site [chemical binding]; other site 1133849011471 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849011472 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849011473 Condensation domain; Region: Condensation; pfam00668 1133849011474 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849011475 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849011476 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849011477 acyl-activating enzyme (AAE) consensus motif; other site 1133849011478 AMP binding site [chemical binding]; other site 1133849011479 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849011480 S-adenosylmethionine binding site [chemical binding]; other site 1133849011481 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849011482 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849011483 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1133849011484 DNA binding site [nucleotide binding] 1133849011485 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1133849011486 NB-ARC domain; Region: NB-ARC; pfam00931 1133849011487 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1133849011488 binding surface 1133849011489 TPR motif; other site 1133849011490 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849011491 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1133849011492 TPR motif; other site 1133849011493 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849011494 binding surface 1133849011495 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849011496 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1133849011497 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849011498 NAD(P) binding site [chemical binding]; other site 1133849011499 active site 1133849011500 Condensation domain; Region: Condensation; pfam00668 1133849011501 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849011502 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 1133849011503 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1133849011504 metal binding site [ion binding]; metal-binding site 1133849011505 dimer interface [polypeptide binding]; other site 1133849011506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849011507 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1133849011508 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1133849011509 active site 1133849011510 NAD binding site [chemical binding]; other site 1133849011511 metal binding site [ion binding]; metal-binding site 1133849011512 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 1133849011513 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1133849011514 ligand binding site [chemical binding]; other site 1133849011515 NAD binding site [chemical binding]; other site 1133849011516 catalytic site [active] 1133849011517 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1133849011518 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1133849011519 tetramer interface [polypeptide binding]; other site 1133849011520 active site 1133849011521 Mg2+/Mn2+ binding site [ion binding]; other site 1133849011522 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1133849011523 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 1133849011524 PYR/PP interface [polypeptide binding]; other site 1133849011525 dimer interface [polypeptide binding]; other site 1133849011526 TPP binding site [chemical binding]; other site 1133849011527 Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as...; Region: TPP_PpyrDC; cd03371 1133849011528 TPP-binding site; other site 1133849011529 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1133849011530 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1133849011531 NAD(P) binding site [chemical binding]; other site 1133849011532 catalytic residues [active] 1133849011533 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1133849011534 classical (c) SDRs; Region: SDR_c; cd05233 1133849011535 NAD(P) binding site [chemical binding]; other site 1133849011536 active site 1133849011537 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849011538 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1133849011539 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849011540 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849011541 AMP binding site [chemical binding]; other site 1133849011542 active site 1133849011543 acyl-activating enzyme (AAE) consensus motif; other site 1133849011544 CoA binding site [chemical binding]; other site 1133849011545 hypothetical protein; Provisional; Region: PRK06062 1133849011546 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1133849011547 inhibitor-cofactor binding pocket; inhibition site 1133849011548 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849011549 catalytic residue [active] 1133849011550 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1133849011551 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1133849011552 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1133849011553 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1133849011554 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1133849011555 Walker A/P-loop; other site 1133849011556 ATP binding site [chemical binding]; other site 1133849011557 Q-loop/lid; other site 1133849011558 ABC transporter signature motif; other site 1133849011559 Walker B; other site 1133849011560 D-loop; other site 1133849011561 H-loop/switch region; other site 1133849011562 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1133849011563 Beta-lactamase; Region: Beta-lactamase; pfam00144 1133849011564 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1133849011565 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1133849011566 active site 1133849011567 ATP-binding site [chemical binding]; other site 1133849011568 pantoate-binding site; other site 1133849011569 HXXH motif; other site 1133849011570 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849011571 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849011572 active site 1133849011573 phosphorylation site [posttranslational modification] 1133849011574 intermolecular recognition site; other site 1133849011575 dimerization interface [polypeptide binding]; other site 1133849011576 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849011577 DNA binding residues [nucleotide binding] 1133849011578 dimerization interface [polypeptide binding]; other site 1133849011579 Histidine kinase; Region: HisKA_3; pfam07730 1133849011580 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1133849011581 ATP binding site [chemical binding]; other site 1133849011582 Mg2+ binding site [ion binding]; other site 1133849011583 G-X-G motif; other site 1133849011584 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1133849011585 Coenzyme A binding pocket [chemical binding]; other site 1133849011586 AAA ATPase domain; Region: AAA_16; pfam13191 1133849011587 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849011588 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849011589 DNA binding residues [nucleotide binding] 1133849011590 dimerization interface [polypeptide binding]; other site 1133849011591 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1133849011592 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1133849011593 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1133849011594 conserved cys residue [active] 1133849011595 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1133849011596 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1133849011597 conserved cys residue [active] 1133849011598 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849011599 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849011600 Helix-turn-helix domain; Region: HTH_18; pfam12833 1133849011601 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849011602 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849011603 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 1133849011604 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1133849011605 active site 1133849011606 Zn binding site [ion binding]; other site 1133849011607 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1133849011608 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1133849011609 short chain dehydrogenase; Provisional; Region: PRK06701 1133849011610 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1133849011611 NAD binding site [chemical binding]; other site 1133849011612 metal binding site [ion binding]; metal-binding site 1133849011613 active site 1133849011614 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1133849011615 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1133849011616 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1133849011617 threonine synthase; Validated; Region: PRK08197 1133849011618 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1133849011619 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849011620 catalytic residue [active] 1133849011621 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 1133849011622 Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080 1133849011623 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893 1133849011624 putative catalytic cysteine [active] 1133849011625 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1133849011626 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 1133849011627 acyl transferase; Provisional; Region: luxD; PRK13604 1133849011628 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1133849011629 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1133849011630 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 1133849011631 Adenosylhomocysteinase; Provisional; Region: PTZ00075 1133849011632 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1133849011633 homotetramer interface [polypeptide binding]; other site 1133849011634 ligand binding site [chemical binding]; other site 1133849011635 catalytic site [active] 1133849011636 NAD binding site [chemical binding]; other site 1133849011637 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1133849011638 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1133849011639 active site 1133849011640 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 1133849011641 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1133849011642 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1133849011643 Glycine/serine hydroxymethyltransferase [Amino acid transport and metabolism]; Region: GlyA; COG0112 1133849011644 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849011645 catalytic residue [active] 1133849011646 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 1133849011647 active site 1133849011648 Zn2+ binding site [ion binding]; other site 1133849011649 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1133849011650 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849011651 non-specific DNA binding site [nucleotide binding]; other site 1133849011652 salt bridge; other site 1133849011653 sequence-specific DNA binding site [nucleotide binding]; other site 1133849011654 Cupin domain; Region: Cupin_2; cl17218 1133849011655 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1133849011656 EamA-like transporter family; Region: EamA; pfam00892 1133849011657 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849011658 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849011659 DNA binding residues [nucleotide binding] 1133849011660 dimerization interface [polypeptide binding]; other site 1133849011661 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1133849011662 Ligand Binding Site [chemical binding]; other site 1133849011663 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 1133849011664 putative deacylase active site [active] 1133849011665 Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764 1133849011666 Peptidase M15; Region: Peptidase_M15_3; cl01194 1133849011667 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1133849011668 Bacterial transcriptional activator domain; Region: BTAD; smart01043 1133849011669 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1133849011670 Zn binding site [ion binding]; other site 1133849011671 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1133849011672 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849011673 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1133849011674 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1133849011675 NAD(P) binding site [chemical binding]; other site 1133849011676 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849011677 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849011678 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1133849011679 FAD binding domain; Region: FAD_binding_4; pfam01565 1133849011680 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1133849011681 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1133849011682 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1133849011683 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1133849011684 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 1133849011685 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 1133849011686 tetramer interface [polypeptide binding]; other site 1133849011687 active site 1133849011688 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1133849011689 active site 1133849011690 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1133849011691 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1133849011692 active site 1133849011693 potential frameshift: common BLAST hit: gi|54025487|ref|YP_119729.1| ayl-CoA thiolase 1133849011694 Coenzyme A transferase; Region: CoA_trans; cl17247 1133849011695 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1133849011696 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 1133849011697 hypothetical protein; Provisional; Region: PRK07236 1133849011698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849011699 benzoate transport; Region: 2A0115; TIGR00895 1133849011700 putative substrate translocation pore; other site 1133849011701 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1133849011702 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1133849011703 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1133849011704 dimerization interface [polypeptide binding]; other site 1133849011705 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1133849011706 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1133849011707 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1133849011708 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1133849011709 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1133849011710 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1133849011711 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1133849011712 active site 1133849011713 metal binding site [ion binding]; metal-binding site 1133849011714 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1133849011715 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1133849011716 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1133849011717 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1133849011718 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849011719 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1133849011720 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1133849011721 dimer interface [polypeptide binding]; other site 1133849011722 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849011723 catalytic residue [active] 1133849011724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849011725 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1133849011726 putative substrate translocation pore; other site 1133849011727 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1133849011728 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1133849011729 ligand binding site [chemical binding]; other site 1133849011730 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 1133849011731 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849011732 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1133849011733 DNA binding residues [nucleotide binding] 1133849011734 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849011735 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1133849011736 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1133849011737 FAD binding site [chemical binding]; other site 1133849011738 hypothetical protein; Provisional; Region: PHA02754 1133849011739 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849011740 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1133849011741 active site 1133849011742 metal binding site [ion binding]; metal-binding site 1133849011743 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1133849011744 Zn binding site [ion binding]; other site 1133849011745 Predicted transcriptional regulators [Transcription]; Region: COG1695 1133849011746 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1133849011747 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1133849011748 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1133849011749 FMN-binding pocket [chemical binding]; other site 1133849011750 flavin binding motif; other site 1133849011751 phosphate binding motif [ion binding]; other site 1133849011752 beta-alpha-beta structure motif; other site 1133849011753 NAD binding pocket [chemical binding]; other site 1133849011754 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1133849011755 catalytic loop [active] 1133849011756 iron binding site [ion binding]; other site 1133849011757 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849011758 putative methyltransferase; Provisional; Region: PRK14967 1133849011759 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1133849011760 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 1133849011761 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1133849011762 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1133849011763 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1133849011764 iron-sulfur cluster [ion binding]; other site 1133849011765 [2Fe-2S] cluster binding site [ion binding]; other site 1133849011766 hydroperoxidase II; Provisional; Region: katE; PRK11249 1133849011767 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1133849011768 heme binding pocket [chemical binding]; other site 1133849011769 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1133849011770 domain interactions; other site 1133849011771 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849011772 Cytochrome P450; Region: p450; cl12078 1133849011773 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1133849011774 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1133849011775 nucleotide binding pocket [chemical binding]; other site 1133849011776 K-X-D-G motif; other site 1133849011777 catalytic site [active] 1133849011778 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1133849011779 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1133849011780 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1133849011781 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1133849011782 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1133849011783 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1133849011784 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1133849011785 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1133849011786 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1133849011787 active site 1133849011788 ATP binding site [chemical binding]; other site 1133849011789 substrate binding site [chemical binding]; other site 1133849011790 activation loop (A-loop); other site 1133849011791 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1133849011792 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849011793 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849011794 non-specific DNA binding site [nucleotide binding]; other site 1133849011795 salt bridge; other site 1133849011796 sequence-specific DNA binding site [nucleotide binding]; other site 1133849011797 hypothetical protein; Provisional; Region: PRK06834 1133849011798 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1133849011799 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1133849011800 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1133849011801 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1133849011802 dimerization interface [polypeptide binding]; other site 1133849011803 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1133849011804 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1133849011805 Walker A/P-loop; other site 1133849011806 ATP binding site [chemical binding]; other site 1133849011807 Q-loop/lid; other site 1133849011808 ABC transporter signature motif; other site 1133849011809 Walker B; other site 1133849011810 D-loop; other site 1133849011811 H-loop/switch region; other site 1133849011812 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 1133849011813 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1133849011814 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; COG0310 1133849011815 PDGLE domain; Region: PDGLE; cl07986 1133849011816 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849011817 dimerization interface [polypeptide binding]; other site 1133849011818 putative DNA binding site [nucleotide binding]; other site 1133849011819 putative Zn2+ binding site [ion binding]; other site 1133849011820 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 1133849011821 Cupin; Region: Cupin_1; smart00835 1133849011822 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1133849011823 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849011824 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1133849011825 DNA binding residues [nucleotide binding] 1133849011826 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1133849011827 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1133849011828 NAD(P) binding site [chemical binding]; other site 1133849011829 Helix-turn-helix domain; Region: HTH_18; pfam12833 1133849011830 Beta-lactamase; Region: Beta-lactamase; pfam00144 1133849011831 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1133849011832 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849011833 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1133849011834 active site 1133849011835 LGFP repeat; Region: LGFP; pfam08310 1133849011836 LGFP repeat; Region: LGFP; pfam08310 1133849011837 LGFP repeat; Region: LGFP; pfam08310 1133849011838 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849011839 putative Zn2+ binding site [ion binding]; other site 1133849011840 putative DNA binding site [nucleotide binding]; other site 1133849011841 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1133849011842 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1133849011843 MspA; Region: MspA; pfam09203 1133849011844 MspA; Region: MspA; pfam09203 1133849011845 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 1133849011846 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849011847 Cytochrome P450; Region: p450; cl12078 1133849011848 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849011849 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849011850 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1133849011851 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1133849011852 DNA binding site [nucleotide binding] 1133849011853 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1133849011854 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1133849011855 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1133849011856 D-pathway; other site 1133849011857 Putative ubiquinol binding site [chemical binding]; other site 1133849011858 Low-spin heme (heme b) binding site [chemical binding]; other site 1133849011859 Putative water exit pathway; other site 1133849011860 Binuclear center (heme o3/CuB) [ion binding]; other site 1133849011861 K-pathway; other site 1133849011862 Putative proton exit pathway; other site 1133849011863 acyltransferase PapA5; Provisional; Region: PRK09294 1133849011864 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1133849011865 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1133849011866 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 1133849011867 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1133849011868 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1133849011869 molybdopterin cofactor binding site; other site 1133849011870 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1133849011871 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1133849011872 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1133849011873 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1133849011874 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1133849011875 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1133849011876 [4Fe-4S] binding site [ion binding]; other site 1133849011877 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1133849011878 metabolite-proton symporter; Region: 2A0106; TIGR00883 1133849011879 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849011880 putative substrate translocation pore; other site 1133849011881 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849011882 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1133849011883 active site 1133849011884 Predicted transcriptional regulator [Transcription]; Region: COG2378 1133849011885 HTH domain; Region: HTH_11; pfam08279 1133849011886 WYL domain; Region: WYL; pfam13280 1133849011887 SnoaL-like domain; Region: SnoaL_2; pfam12680 1133849011888 Protein of unknown function, DUF488; Region: DUF488; pfam04343 1133849011889 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1133849011890 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1133849011891 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1133849011892 putative active site [active] 1133849011893 ATP binding site [chemical binding]; other site 1133849011894 putative substrate binding site [chemical binding]; other site 1133849011895 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 1133849011896 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1133849011897 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849011898 putative substrate translocation pore; other site 1133849011899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849011900 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 1133849011901 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849011902 WHG domain; Region: WHG; pfam13305 1133849011903 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1133849011904 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 1133849011905 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 1133849011906 homodimer interface [polypeptide binding]; other site 1133849011907 homotetramer interface [polypeptide binding]; other site 1133849011908 active site pocket [active] 1133849011909 cleavage site 1133849011910 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849011911 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849011912 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1133849011913 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1133849011914 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849011915 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1133849011916 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1133849011917 Walker A/P-loop; other site 1133849011918 ATP binding site [chemical binding]; other site 1133849011919 Q-loop/lid; other site 1133849011920 ABC transporter signature motif; other site 1133849011921 Walker B; other site 1133849011922 D-loop; other site 1133849011923 H-loop/switch region; other site 1133849011924 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1133849011925 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1133849011926 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1133849011927 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1133849011928 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1133849011929 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1133849011930 TM-ABC transporter signature motif; other site 1133849011931 sorbitol dehydrogenase; Provisional; Region: PRK07067 1133849011932 classical (c) SDRs; Region: SDR_c; cd05233 1133849011933 NAD(P) binding site [chemical binding]; other site 1133849011934 active site 1133849011935 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 1133849011936 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1133849011937 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1133849011938 choline dehydrogenase; Validated; Region: PRK02106 1133849011939 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1133849011940 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1133849011941 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1133849011942 ornithine cyclodeaminase; Validated; Region: PRK06199 1133849011943 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1133849011944 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1133849011945 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1133849011946 active site 1133849011947 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1133849011948 phenol 2-monooxygenase; Provisional; Region: PRK08294 1133849011949 FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979 1133849011950 dimer interface [polypeptide binding]; other site 1133849011951 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849011952 metabolite-proton symporter; Region: 2A0106; TIGR00883 1133849011953 putative substrate translocation pore; other site 1133849011954 hypothetical protein; Provisional; Region: PRK12764 1133849011955 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1133849011956 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 1133849011957 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1133849011958 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1133849011959 DNA-binding site [nucleotide binding]; DNA binding site 1133849011960 FCD domain; Region: FCD; pfam07729 1133849011961 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 1133849011962 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1133849011963 NAD binding site [chemical binding]; other site 1133849011964 catalytic residues [active] 1133849011965 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 1133849011966 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 1133849011967 tetramer interface [polypeptide binding]; other site 1133849011968 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 1133849011969 tetramer interface [polypeptide binding]; other site 1133849011970 active site 1133849011971 metal binding site [ion binding]; metal-binding site 1133849011972 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1133849011973 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 1133849011974 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1133849011975 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 1133849011976 NAD(P) binding site [chemical binding]; other site 1133849011977 catalytic residues [active] 1133849011978 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1133849011979 SnoaL-like domain; Region: SnoaL_3; pfam13474 1133849011980 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849011981 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1133849011982 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1133849011983 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1133849011984 active site 1133849011985 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1133849011986 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1133849011987 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849011988 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1133849011989 Enoylreductase; Region: PKS_ER; smart00829 1133849011990 NAD(P) binding site [chemical binding]; other site 1133849011991 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1133849011992 putative NADP binding site [chemical binding]; other site 1133849011993 KR domain; Region: KR; pfam08659 1133849011994 active site 1133849011995 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1133849011996 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1133849011997 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849011998 acyl-activating enzyme (AAE) consensus motif; other site 1133849011999 AMP binding site [chemical binding]; other site 1133849012000 active site 1133849012001 CoA binding site [chemical binding]; other site 1133849012002 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1133849012003 Erythronolide synthase docking; Region: Docking; pfam08990 1133849012004 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1133849012005 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1133849012006 active site 1133849012007 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1133849012008 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1133849012009 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849012010 Enoylreductase; Region: PKS_ER; smart00829 1133849012011 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1133849012012 NAD(P) binding site [chemical binding]; other site 1133849012013 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1133849012014 KR domain; Region: KR; pfam08659 1133849012015 putative NADP binding site [chemical binding]; other site 1133849012016 active site 1133849012017 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1133849012018 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 1133849012019 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 1133849012020 Erythronolide synthase docking; Region: Docking; pfam08990 1133849012021 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1133849012022 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1133849012023 active site 1133849012024 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1133849012025 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1133849012026 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1133849012027 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1133849012028 active sites [active] 1133849012029 tetramer interface [polypeptide binding]; other site 1133849012030 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1133849012031 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1133849012032 active site 1133849012033 TDP-binding site; other site 1133849012034 acceptor substrate-binding pocket; other site 1133849012035 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849012036 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849012037 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849012038 putative substrate translocation pore; other site 1133849012039 hypothetical protein; Provisional; Region: PRK07236 1133849012040 hypothetical protein; Provisional; Region: PRK07588 1133849012041 MMPL family; Region: MMPL; pfam03176 1133849012042 MMPL family; Region: MMPL; pfam03176 1133849012043 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1133849012044 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1133849012045 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1133849012046 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849012047 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849012048 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1133849012049 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1133849012050 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 1133849012051 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1133849012052 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 1133849012053 active site 1133849012054 catalytic triad [active] 1133849012055 dimer interface [polypeptide binding]; other site 1133849012056 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1133849012057 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1133849012058 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1133849012059 active site 1133849012060 hypothetical protein; Provisional; Region: PRK06541 1133849012061 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1133849012062 inhibitor-cofactor binding pocket; inhibition site 1133849012063 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849012064 catalytic residue [active] 1133849012065 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1133849012066 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1133849012067 putative DNA binding site [nucleotide binding]; other site 1133849012068 putative Zn2+ binding site [ion binding]; other site 1133849012069 AsnC family; Region: AsnC_trans_reg; pfam01037 1133849012070 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1133849012071 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1133849012072 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1133849012073 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1133849012074 tetrameric interface [polypeptide binding]; other site 1133849012075 NAD binding site [chemical binding]; other site 1133849012076 catalytic residues [active] 1133849012077 substrate binding site [chemical binding]; other site 1133849012078 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1133849012079 4-aminobutyrate aminotransferase, prokaryotic type; Region: GABAtrnsam; TIGR00700 1133849012080 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1133849012081 inhibitor-cofactor binding pocket; inhibition site 1133849012082 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849012083 catalytic residue [active] 1133849012084 succinic semialdehyde dehydrogenase; Region: PLN02278 1133849012085 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1133849012086 tetramerization interface [polypeptide binding]; other site 1133849012087 NAD(P) binding site [chemical binding]; other site 1133849012088 catalytic residues [active] 1133849012089 Helix-turn-helix domain; Region: HTH_18; pfam12833 1133849012090 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 1133849012091 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1133849012092 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1133849012093 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1133849012094 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1133849012095 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 1133849012096 xylose isomerase; Provisional; Region: PRK12677 1133849012097 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 1133849012098 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 1133849012099 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1133849012100 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1133849012101 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1133849012102 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1133849012103 RHS Repeat; Region: RHS_repeat; pfam05593 1133849012104 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1133849012105 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1133849012106 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1133849012107 RHS Repeat; Region: RHS_repeat; pfam05593 1133849012108 RHS Repeat; Region: RHS_repeat; pfam05593 1133849012109 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1133849012110 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849012111 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849012112 active site 1133849012113 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 1133849012114 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1133849012115 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1133849012116 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849012117 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 1133849012118 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849012119 S-adenosylmethionine binding site [chemical binding]; other site 1133849012120 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1133849012121 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1133849012122 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1133849012123 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1133849012124 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1133849012125 Peptidase inhibitor family I36; Region: Inhibitor_I36; pfam03995 1133849012126 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1133849012127 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849012128 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849012129 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1133849012130 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1133849012131 acyl-activating enzyme (AAE) consensus motif; other site 1133849012132 active site 1133849012133 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1133849012134 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849012135 S-adenosylmethionine binding site [chemical binding]; other site 1133849012136 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849012137 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1133849012138 dinuclear metal binding motif [ion binding]; other site 1133849012139 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849012140 acyl-coenzyme A oxidase; Region: PLN02636 1133849012141 active site 1133849012142 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1133849012143 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1133849012144 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1133849012145 DNA binding residues [nucleotide binding] 1133849012146 Condensation domain; Region: Condensation; pfam00668 1133849012147 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849012148 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1133849012149 acyl-activating enzyme (AAE) consensus motif; other site 1133849012150 AMP binding site [chemical binding]; other site 1133849012151 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849012152 Condensation domain; Region: Condensation; pfam00668 1133849012153 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849012154 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849012155 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849012156 acyl-activating enzyme (AAE) consensus motif; other site 1133849012157 AMP binding site [chemical binding]; other site 1133849012158 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849012159 Condensation domain; Region: Condensation; pfam00668 1133849012160 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849012161 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849012162 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849012163 acyl-activating enzyme (AAE) consensus motif; other site 1133849012164 AMP binding site [chemical binding]; other site 1133849012165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849012166 S-adenosylmethionine binding site [chemical binding]; other site 1133849012167 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849012168 Condensation domain; Region: Condensation; pfam00668 1133849012169 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849012170 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849012171 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849012172 acyl-activating enzyme (AAE) consensus motif; other site 1133849012173 AMP binding site [chemical binding]; other site 1133849012174 Condensation domain; Region: Condensation; pfam00668 1133849012175 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1133849012176 Condensation domain; Region: Condensation; pfam00668 1133849012177 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849012178 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1133849012179 acyl-activating enzyme (AAE) consensus motif; other site 1133849012180 AMP binding site [chemical binding]; other site 1133849012181 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849012182 Condensation domain; Region: Condensation; pfam00668 1133849012183 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849012184 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849012185 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849012186 acyl-activating enzyme (AAE) consensus motif; other site 1133849012187 AMP binding site [chemical binding]; other site 1133849012188 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849012189 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1133849012190 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849012191 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849012192 acyl-activating enzyme (AAE) consensus motif; other site 1133849012193 AMP binding site [chemical binding]; other site 1133849012194 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849012195 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849012196 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 1133849012197 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1133849012198 acyl-CoA synthetase; Validated; Region: PRK05850 1133849012199 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1133849012200 acyl-activating enzyme (AAE) consensus motif; other site 1133849012201 active site 1133849012202 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1133849012203 HIGH motif; other site 1133849012204 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1133849012205 active site 1133849012206 KMSKS motif; other site 1133849012207 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1133849012208 tRNA binding surface [nucleotide binding]; other site 1133849012209 Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264 1133849012210 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1133849012211 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1133849012212 conserved cys residue [active] 1133849012213 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 1133849012214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849012215 S-adenosylmethionine binding site [chemical binding]; other site 1133849012216 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1133849012217 active site 1133849012218 catalytic triad [active] 1133849012219 oxyanion hole [active] 1133849012220 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849012221 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 1133849012222 CGNR zinc finger; Region: zf-CGNR; pfam11706 1133849012223 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849012224 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1133849012225 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1133849012226 intersubunit interface [polypeptide binding]; other site 1133849012227 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1133849012228 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849012229 Walker A/P-loop; other site 1133849012230 ATP binding site [chemical binding]; other site 1133849012231 Q-loop/lid; other site 1133849012232 ABC transporter signature motif; other site 1133849012233 Walker B; other site 1133849012234 D-loop; other site 1133849012235 H-loop/switch region; other site 1133849012236 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1133849012237 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 1133849012238 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849012239 Walker A/P-loop; other site 1133849012240 ATP binding site [chemical binding]; other site 1133849012241 Q-loop/lid; other site 1133849012242 ABC transporter signature motif; other site 1133849012243 Walker B; other site 1133849012244 D-loop; other site 1133849012245 H-loop/switch region; other site 1133849012246 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1133849012247 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1133849012248 DNA binding residues [nucleotide binding] 1133849012249 Condensation domain; Region: Condensation; pfam00668 1133849012250 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849012251 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1133849012252 acyl-activating enzyme (AAE) consensus motif; other site 1133849012253 AMP binding site [chemical binding]; other site 1133849012254 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849012255 Condensation domain; Region: Condensation; pfam00668 1133849012256 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849012257 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1133849012258 acyl-activating enzyme (AAE) consensus motif; other site 1133849012259 AMP binding site [chemical binding]; other site 1133849012260 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849012261 Condensation domain; Region: Condensation; pfam00668 1133849012262 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849012263 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849012264 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849012265 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1133849012266 acyl-activating enzyme (AAE) consensus motif; other site 1133849012267 AMP binding site [chemical binding]; other site 1133849012268 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849012269 Condensation domain; Region: Condensation; pfam00668 1133849012270 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1133849012271 Condensation domain; Region: Condensation; pfam00668 1133849012272 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849012273 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849012274 acyl-activating enzyme (AAE) consensus motif; other site 1133849012275 AMP binding site [chemical binding]; other site 1133849012276 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849012277 Condensation domain; Region: Condensation; pfam00668 1133849012278 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1133849012279 Condensation domain; Region: Condensation; pfam00668 1133849012280 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849012281 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1133849012282 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1133849012283 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1133849012284 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1133849012285 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1133849012286 active site 1133849012287 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849012288 Condensation domain; Region: Condensation; pfam00668 1133849012289 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849012290 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849012291 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849012292 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1133849012293 acyl-activating enzyme (AAE) consensus motif; other site 1133849012294 AMP binding site [chemical binding]; other site 1133849012295 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849012296 FkbH-like domain; Region: FkbH; TIGR01686 1133849012297 Acid Phosphatase; Region: Acid_PPase; cl17256 1133849012298 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1133849012299 active site 1133849012300 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849012301 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849012302 active site 1133849012303 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849012304 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1133849012305 TPR motif; other site 1133849012306 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849012307 binding surface 1133849012308 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1133849012309 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1133849012310 DNA-binding site [nucleotide binding]; DNA binding site 1133849012311 FCD domain; Region: FCD; pfam07729 1133849012312 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1133849012313 substrate binding site [chemical binding]; other site 1133849012314 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1133849012315 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1133849012316 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1133849012317 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 1133849012318 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1133849012319 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1133849012320 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849012321 ATP binding site [chemical binding]; other site 1133849012322 Mg2+ binding site [ion binding]; other site 1133849012323 G-X-G motif; other site 1133849012324 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1133849012325 anti sigma factor interaction site; other site 1133849012326 regulatory phosphorylation site [posttranslational modification]; other site 1133849012327 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849012328 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1133849012329 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1133849012330 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849012331 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1133849012332 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1133849012333 B12 binding domain; Region: B12-binding_2; pfam02607 1133849012334 B12 binding domain; Region: B12-binding; pfam02310 1133849012335 B12 binding site [chemical binding]; other site 1133849012336 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1133849012337 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1133849012338 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1133849012339 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1133849012340 anti sigma factor interaction site; other site 1133849012341 regulatory phosphorylation site [posttranslational modification]; other site 1133849012342 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1133849012343 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849012344 Cytochrome P450; Region: p450; cl12078 1133849012345 Bacterial SH3 domain; Region: SH3_3; cl17532 1133849012346 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1133849012347 active site 1133849012348 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849012349 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1133849012350 active site 1133849012351 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849012352 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849012353 amidase; Provisional; Region: PRK07869 1133849012354 Amidase; Region: Amidase; cl11426 1133849012355 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1133849012356 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1133849012357 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1133849012358 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849012359 ABC-ATPase subunit interface; other site 1133849012360 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1133849012361 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1133849012362 Walker A/P-loop; other site 1133849012363 ATP binding site [chemical binding]; other site 1133849012364 Q-loop/lid; other site 1133849012365 ABC transporter signature motif; other site 1133849012366 Walker B; other site 1133849012367 D-loop; other site 1133849012368 H-loop/switch region; other site 1133849012369 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1133849012370 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1133849012371 NodB motif; other site 1133849012372 active site 1133849012373 catalytic site [active] 1133849012374 metal binding site [ion binding]; metal-binding site 1133849012375 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1133849012376 NMT1/THI5 like; Region: NMT1; pfam09084 1133849012377 substrate binding pocket [chemical binding]; other site 1133849012378 membrane-bound complex binding site; other site 1133849012379 hinge residues; other site 1133849012380 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1133849012381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849012382 dimer interface [polypeptide binding]; other site 1133849012383 conserved gate region; other site 1133849012384 putative PBP binding loops; other site 1133849012385 ABC-ATPase subunit interface; other site 1133849012386 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1133849012387 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1133849012388 Walker A/P-loop; other site 1133849012389 ATP binding site [chemical binding]; other site 1133849012390 Q-loop/lid; other site 1133849012391 ABC transporter signature motif; other site 1133849012392 Walker B; other site 1133849012393 D-loop; other site 1133849012394 H-loop/switch region; other site 1133849012395 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1133849012396 Cytochrome P450; Region: p450; cl12078 1133849012397 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849012398 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849012399 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1133849012400 Walker A/P-loop; other site 1133849012401 ATP binding site [chemical binding]; other site 1133849012402 Q-loop/lid; other site 1133849012403 ABC transporter signature motif; other site 1133849012404 Walker B; other site 1133849012405 D-loop; other site 1133849012406 H-loop/switch region; other site 1133849012407 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1133849012408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849012409 S-adenosylmethionine binding site [chemical binding]; other site 1133849012410 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1133849012411 hypothetical protein; Provisional; Region: PRK06184 1133849012412 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1133849012413 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849012414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849012415 active site 1133849012416 phosphorylation site [posttranslational modification] 1133849012417 intermolecular recognition site; other site 1133849012418 dimerization interface [polypeptide binding]; other site 1133849012419 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849012420 DNA binding residues [nucleotide binding] 1133849012421 dimerization interface [polypeptide binding]; other site 1133849012422 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1133849012423 Histidine kinase; Region: HisKA_3; pfam07730 1133849012424 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849012425 ATP binding site [chemical binding]; other site 1133849012426 Mg2+ binding site [ion binding]; other site 1133849012427 G-X-G motif; other site 1133849012428 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1133849012429 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849012430 Walker A/P-loop; other site 1133849012431 ATP binding site [chemical binding]; other site 1133849012432 Q-loop/lid; other site 1133849012433 ABC transporter signature motif; other site 1133849012434 Walker B; other site 1133849012435 D-loop; other site 1133849012436 H-loop/switch region; other site 1133849012437 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1133849012438 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1133849012439 structural tetrad; other site 1133849012440 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1133849012441 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1133849012442 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1133849012443 structural tetrad; other site 1133849012444 Histidine kinase; Region: HisKA_3; pfam07730 1133849012445 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1133849012446 ATP binding site [chemical binding]; other site 1133849012447 Mg2+ binding site [ion binding]; other site 1133849012448 G-X-G motif; other site 1133849012449 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849012450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849012451 active site 1133849012452 phosphorylation site [posttranslational modification] 1133849012453 intermolecular recognition site; other site 1133849012454 dimerization interface [polypeptide binding]; other site 1133849012455 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849012456 DNA binding residues [nucleotide binding] 1133849012457 dimerization interface [polypeptide binding]; other site 1133849012458 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1133849012459 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849012460 Protein of unknown function (DUF1702); Region: DUF1702; pfam08012 1133849012461 Family description; Region: VCBS; pfam13517 1133849012462 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 1133849012463 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1133849012464 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1133849012465 active site 1133849012466 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1133849012467 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1133849012468 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1133849012469 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1133849012470 putative NADP binding site [chemical binding]; other site 1133849012471 active site 1133849012472 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1133849012473 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1133849012474 active site 1133849012475 Predicted transcriptional regulators [Transcription]; Region: COG1733 1133849012476 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1133849012477 SCP-2 sterol transfer family; Region: SCP2; cl01225 1133849012478 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1133849012479 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1133849012480 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 1133849012481 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1133849012482 homodimer interface [polypeptide binding]; other site 1133849012483 substrate-cofactor binding pocket; other site 1133849012484 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849012485 catalytic residue [active] 1133849012486 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1133849012487 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849012488 S-adenosylmethionine binding site [chemical binding]; other site 1133849012489 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1133849012490 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1133849012491 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849012492 catalytic residue [active] 1133849012493 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1133849012494 ABC1 family; Region: ABC1; pfam03109 1133849012495 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1133849012496 active site 1133849012497 ATP binding site [chemical binding]; other site 1133849012498 adenosine deaminase; Provisional; Region: PRK09358 1133849012499 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1133849012500 active site 1133849012501 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1133849012502 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1133849012503 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849012504 catalytic residue [active] 1133849012505 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1133849012506 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1133849012507 PAS domain; Region: PAS_9; pfam13426 1133849012508 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1133849012509 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849012510 ATP binding site [chemical binding]; other site 1133849012511 Mg2+ binding site [ion binding]; other site 1133849012512 G-X-G motif; other site 1133849012513 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849012514 active site 1133849012515 phosphorylation site [posttranslational modification] 1133849012516 intermolecular recognition site; other site 1133849012517 dimerization interface [polypeptide binding]; other site 1133849012518 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1133849012519 Ca2+ binding site [ion binding]; other site 1133849012520 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1133849012521 Ca2+ binding site [ion binding]; other site 1133849012522 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1133849012523 Ca2+ binding site [ion binding]; other site 1133849012524 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1133849012525 hydrophobic ligand binding site; other site 1133849012526 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849012527 S-adenosylmethionine binding site [chemical binding]; other site 1133849012528 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1133849012529 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1133849012530 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849012531 putative substrate translocation pore; other site 1133849012532 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1133849012533 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1133849012534 Ca2+ binding site [ion binding]; other site 1133849012535 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 1133849012536 EF-hand domain pair; Region: EF_hand_5; pfam13499 1133849012537 Ca2+ binding site [ion binding]; other site 1133849012538 Cytochrome P450; Region: p450; cl12078 1133849012539 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849012540 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 1133849012541 putative hydrophobic ligand binding site [chemical binding]; other site 1133849012542 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901 1133849012543 putative hydrophobic ligand binding site [chemical binding]; other site 1133849012544 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 1133849012545 peptide binding site [polypeptide binding]; other site 1133849012546 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1133849012547 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 1133849012548 peptide binding site [polypeptide binding]; other site 1133849012549 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1133849012550 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1133849012551 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849012552 S-adenosylmethionine binding site [chemical binding]; other site 1133849012553 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1133849012554 Bacterial protein of unknown function (DUF899); Region: DUF899; cl17828 1133849012555 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1133849012556 putative hydrophobic ligand binding site [chemical binding]; other site 1133849012557 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1133849012558 putative hydrophobic ligand binding site [chemical binding]; other site 1133849012559 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849012560 dimerization interface [polypeptide binding]; other site 1133849012561 putative DNA binding site [nucleotide binding]; other site 1133849012562 putative Zn2+ binding site [ion binding]; other site 1133849012563 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 1133849012564 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1133849012565 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1133849012566 Bacterial transcriptional regulator; Region: IclR; pfam01614 1133849012567 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1133849012568 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1133849012569 DNA-binding site [nucleotide binding]; DNA binding site 1133849012570 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1133849012571 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 1133849012572 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849012573 putative metal binding site [ion binding]; other site 1133849012574 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1133849012575 classical (c) SDRs; Region: SDR_c; cd05233 1133849012576 NAD(P) binding site [chemical binding]; other site 1133849012577 active site 1133849012578 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1133849012579 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1133849012580 DNA-binding site [nucleotide binding]; DNA binding site 1133849012581 FCD domain; Region: FCD; pfam07729 1133849012582 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1133849012583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849012584 putative substrate translocation pore; other site 1133849012585 enterobactin exporter EntS; Provisional; Region: PRK10489 1133849012586 Cupin domain; Region: Cupin_2; pfam07883 1133849012587 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1133849012588 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849012589 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849012590 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1133849012591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849012592 metabolite-proton symporter; Region: 2A0106; TIGR00883 1133849012593 putative substrate translocation pore; other site 1133849012594 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1133849012595 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1133849012596 MarR family; Region: MarR_2; pfam12802 1133849012597 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1133849012598 iron-sulfur cluster [ion binding]; other site 1133849012599 [2Fe-2S] cluster binding site [ion binding]; other site 1133849012600 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 1133849012601 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1133849012602 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1133849012603 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1133849012604 active site lid residues [active] 1133849012605 substrate binding pocket [chemical binding]; other site 1133849012606 catalytic residues [active] 1133849012607 substrate-Mg2+ binding site; other site 1133849012608 aspartate-rich region 1; other site 1133849012609 aspartate-rich region 2; other site 1133849012610 phytoene desaturase; Region: crtI_fam; TIGR02734 1133849012611 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1133849012612 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1133849012613 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1133849012614 substrate binding pocket [chemical binding]; other site 1133849012615 chain length determination region; other site 1133849012616 substrate-Mg2+ binding site; other site 1133849012617 catalytic residues [active] 1133849012618 aspartate-rich region 1; other site 1133849012619 active site lid residues [active] 1133849012620 aspartate-rich region 2; other site 1133849012621 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1133849012622 active site 1133849012623 TDP-binding site; other site 1133849012624 acceptor substrate-binding pocket; other site 1133849012625 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1133849012626 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1133849012627 DNA binding residues [nucleotide binding] 1133849012628 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1133849012629 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1133849012630 TspO/MBR family; Region: TspO_MBR; pfam03073 1133849012631 Beta-lactamase; Region: Beta-lactamase; pfam00144 1133849012632 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1133849012633 Beta-lactamase; Region: Beta-lactamase; pfam00144 1133849012634 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1133849012635 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849012636 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849012637 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849012638 non-specific DNA binding site [nucleotide binding]; other site 1133849012639 salt bridge; other site 1133849012640 sequence-specific DNA binding site [nucleotide binding]; other site 1133849012641 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849012642 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1133849012643 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1133849012644 SnoaL-like domain; Region: SnoaL_3; pfam13474 1133849012645 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849012646 hypothetical protein; Provisional; Region: PRK06753 1133849012647 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1133849012648 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1133849012649 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849012650 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1133849012651 hypothetical protein; Provisional; Region: PRK07236 1133849012652 hypothetical protein; Provisional; Region: PRK07538 1133849012653 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1133849012654 active site 1133849012655 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1133849012656 active site 1133849012657 metal binding site [ion binding]; metal-binding site 1133849012658 homotetramer interface [polypeptide binding]; other site 1133849012659 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 1133849012660 Predicted PP-loop superfamily ATPase [General function prediction only]; Region: COG0603 1133849012661 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1133849012662 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1133849012663 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1133849012664 active site 1133849012665 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1133849012666 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1133849012667 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849012668 Walker A/P-loop; other site 1133849012669 ATP binding site [chemical binding]; other site 1133849012670 Q-loop/lid; other site 1133849012671 ABC transporter signature motif; other site 1133849012672 Walker B; other site 1133849012673 D-loop; other site 1133849012674 H-loop/switch region; other site 1133849012675 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1133849012676 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1133849012677 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849012678 Walker A/P-loop; other site 1133849012679 ATP binding site [chemical binding]; other site 1133849012680 Q-loop/lid; other site 1133849012681 ABC transporter signature motif; other site 1133849012682 Walker B; other site 1133849012683 D-loop; other site 1133849012684 H-loop/switch region; other site 1133849012685 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 1133849012686 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1133849012687 active site 1133849012688 SUMO-1 interface [polypeptide binding]; other site 1133849012689 Predicted transcriptional regulators [Transcription]; Region: COG1733 1133849012690 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1133849012691 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1133849012692 Recombinase; Region: Recombinase; pfam07508 1133849012693 Domain of unknown function (DUF4041); Region: DUF4041; pfam13250 1133849012694 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 1133849012695 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1133849012696 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1133849012697 active site 1133849012698 Zn binding site [ion binding]; other site 1133849012699 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1133849012700 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1133849012701 Coenzyme A binding pocket [chemical binding]; other site 1133849012702 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 1133849012703 dimer interface [polypeptide binding]; other site 1133849012704 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849012705 ligand binding site [chemical binding]; other site 1133849012706 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1133849012707 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1133849012708 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1133849012709 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849012710 S-adenosylmethionine binding site [chemical binding]; other site 1133849012711 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1133849012712 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1133849012713 DNA binding residues [nucleotide binding] 1133849012714 dimer interface [polypeptide binding]; other site 1133849012715 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1133849012716 Phosphotransferase enzyme family; Region: APH; pfam01636 1133849012717 Ecdysteroid kinase; Region: EcKinase; cl17738 1133849012718 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849012719 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1133849012720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849012721 S-adenosylmethionine binding site [chemical binding]; other site 1133849012722 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 1133849012723 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1133849012724 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1133849012725 tetramer interface [polypeptide binding]; other site 1133849012726 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849012727 catalytic residue [active] 1133849012728 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1133849012729 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1133849012730 active site 1133849012731 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 1133849012732 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1133849012733 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849012734 homodimer interface [polypeptide binding]; other site 1133849012735 catalytic residue [active] 1133849012736 FAD binding domain; Region: FAD_binding_4; pfam01565 1133849012737 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1133849012738 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1133849012739 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1133849012740 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849012741 homodimer interface [polypeptide binding]; other site 1133849012742 catalytic residue [active] 1133849012743 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1133849012744 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1133849012745 dimerization interface [polypeptide binding]; other site 1133849012746 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 1133849012747 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1133849012748 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849012749 homodimer interface [polypeptide binding]; other site 1133849012750 catalytic residue [active] 1133849012751 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cl08497 1133849012752 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1133849012753 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693 1133849012754 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 1133849012755 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cl09719 1133849012756 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044 1133849012757 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 1133849012758 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1133849012759 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1133849012760 DNA binding residues [nucleotide binding] 1133849012761 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1133849012762 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1133849012763 Double zinc ribbon; Region: DZR; pfam12773 1133849012764 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1133849012765 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 1133849012766 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849012767 sequence-specific DNA binding site [nucleotide binding]; other site 1133849012768 salt bridge; other site 1133849012769 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1133849012770 Subtilase family; Region: Peptidase_S8; pfam00082 1133849012771 active site 1133849012772 catalytic residues [active] 1133849012773 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1133849012774 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1133849012775 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1133849012776 EspG family; Region: ESX-1_EspG; pfam14011 1133849012777 PPE family; Region: PPE; pfam00823 1133849012778 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1133849012779 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1133849012780 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1133849012781 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1133849012782 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1133849012783 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1133849012784 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 1133849012785 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1133849012786 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1133849012787 Walker A motif; other site 1133849012788 ATP binding site [chemical binding]; other site 1133849012789 Walker B motif; other site 1133849012790 arginine finger; other site 1133849012791 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1133849012792 NlpC/P60 family; Region: NLPC_P60; cl17555 1133849012793 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1133849012794 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1133849012795 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1133849012796 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1133849012797 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1133849012798 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849012799 homodimer interface [polypeptide binding]; other site 1133849012800 catalytic residue [active] 1133849012801 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1133849012802 NlpC/P60 family; Region: NLPC_P60; pfam00877 1133849012803 AAA-like domain; Region: AAA_10; pfam12846 1133849012804 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 1133849012805 Transcription factor WhiB; Region: Whib; pfam02467 1133849012806 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1133849012807 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1133849012808 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1133849012809 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1133849012810 DNA binding residues [nucleotide binding] 1133849012811 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1133849012812 pentamer interface [polypeptide binding]; other site 1133849012813 dodecaamer interface [polypeptide binding]; other site 1133849012814 SET domain; Region: SET; pfam00856 1133849012815 Predicted esterase [General function prediction only]; Region: COG0627 1133849012816 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1133849012817 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1133849012818 substrate binding pocket [chemical binding]; other site 1133849012819 aspartate-rich region 2; other site 1133849012820 substrate-Mg2+ binding site; other site 1133849012821 PAS domain S-box; Region: sensory_box; TIGR00229 1133849012822 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1133849012823 putative active site [active] 1133849012824 heme pocket [chemical binding]; other site 1133849012825 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1133849012826 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1133849012827 metal binding site [ion binding]; metal-binding site 1133849012828 active site 1133849012829 I-site; other site 1133849012830 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1133849012831 metal binding site [ion binding]; metal-binding site 1133849012832 active site 1133849012833 I-site; other site 1133849012834 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1133849012835 Transcription factor WhiB; Region: Whib; pfam02467 1133849012836 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1133849012837 Coenzyme A binding pocket [chemical binding]; other site 1133849012838 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1133849012839 Amidase; Region: Amidase; cl11426 1133849012840 Amidase; Region: Amidase; cl11426 1133849012841 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1133849012842 active site 1 [active] 1133849012843 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1133849012844 active site 2 [active] 1133849012845 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1133849012846 active site 2 [active] 1133849012847 active site 1 [active] 1133849012848 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1133849012849 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1133849012850 substrate binding pocket [chemical binding]; other site 1133849012851 chain length determination region; other site 1133849012852 substrate-Mg2+ binding site; other site 1133849012853 catalytic residues [active] 1133849012854 aspartate-rich region 1; other site 1133849012855 active site lid residues [active] 1133849012856 aspartate-rich region 2; other site 1133849012857 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849012858 S-adenosylmethionine binding site [chemical binding]; other site 1133849012859 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1133849012860 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849012861 NAD(P) binding site [chemical binding]; other site 1133849012862 active site 1133849012863 Ribosomal protein L11 [Translation, ribosomal structure and biogenesis]; Region: RplK; COG0080 1133849012864 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1133849012865 23S rRNA interface [nucleotide binding]; other site 1133849012866 L7/L12 interface [polypeptide binding]; other site 1133849012867 putative thiostrepton binding site; other site 1133849012868 L25 interface [polypeptide binding]; other site 1133849012869 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849012870 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849012871 active site 1133849012872 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 1133849012873 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1133849012874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849012875 S-adenosylmethionine binding site [chemical binding]; other site 1133849012876 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849012877 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1133849012878 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849012879 Predicted ATPase [General function prediction only]; Region: COG3903 1133849012880 AAA ATPase domain; Region: AAA_16; pfam13191 1133849012881 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 1133849012882 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1133849012883 hypothetical protein; Provisional; Region: PRK10621 1133849012884 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849012885 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849012886 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1133849012887 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1133849012888 catalytic residue [active] 1133849012889 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 1133849012890 Lsr2; Region: Lsr2; pfam11774 1133849012891 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1133849012892 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1133849012893 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1133849012894 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 1133849012895 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1133849012896 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1133849012897 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1133849012898 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1133849012899 ParB-like nuclease domain; Region: ParBc; cl02129 1133849012900 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 1133849012901 polymerase nucleotide-binding site; other site 1133849012902 DNA-binding residues [nucleotide binding]; DNA binding site 1133849012903 nucleotide binding site [chemical binding]; other site 1133849012904 primase nucleotide-binding site [nucleotide binding]; other site 1133849012905 Protein of unknown function (DUF3085); Region: DUF3085; pfam11284 1133849012906 Protein of unknown function (DUF3085); Region: DUF3085; pfam11284 1133849012907 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1133849012908 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1133849012909 dimer interface [polypeptide binding]; other site 1133849012910 ssDNA binding site [nucleotide binding]; other site 1133849012911 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1133849012912 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1133849012913 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1133849012914 ssDNA binding site [nucleotide binding]; other site 1133849012915 dimer interface [polypeptide binding]; other site 1133849012916 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1133849012917 TrwC relaxase; Region: TrwC; pfam08751 1133849012918 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 1133849012919 AAA domain; Region: AAA_30; pfam13604 1133849012920 Family description; Region: UvrD_C_2; pfam13538 1133849012921 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1133849012922 nucleotide binding site/active site [active] 1133849012923 HIT family signature motif; other site 1133849012924 catalytic residue [active] 1133849012925 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1133849012926 FAD binding domain; Region: FAD_binding_4; pfam01565 1133849012927 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1133849012928 DinB superfamily; Region: DinB_2; pfam12867 1133849012929 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 1133849012930 Caspase domain; Region: Peptidase_C14; pfam00656 1133849012931 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1133849012932 structural tetrad; other site 1133849012933 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1133849012934 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1133849012935 structural tetrad; other site 1133849012936 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1133849012937 PGAP1-like protein; Region: PGAP1; pfam07819 1133849012938 potential frameshift: common BLAST hit: gi|386836175|ref|YP_006241233.1| IS110 family transposase 1133849012939 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 1133849012940 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1133849012941 DNA binding site [nucleotide binding] 1133849012942 Int/Topo IB signature motif; other site 1133849012943 active site 1133849012944 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1133849012945 DNA binding site [nucleotide binding] 1133849012946 active site 1133849012947 Int/Topo IB signature motif; other site 1133849012948 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1133849012949 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1133849012950 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1133849012951 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1133849012952 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1133849012953 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1133849012954 inhibitor site; inhibition site 1133849012955 active site 1133849012956 dimer interface [polypeptide binding]; other site 1133849012957 catalytic residue [active] 1133849012958 AAA domain; Region: AAA_33; pfam13671 1133849012959 AAA domain; Region: AAA_17; pfam13207 1133849012960 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1133849012961 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1133849012962 Probable Catalytic site; other site 1133849012963 metal-binding site 1133849012964 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1133849012965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849012966 S-adenosylmethionine binding site [chemical binding]; other site 1133849012967 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1133849012968 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849012969 NAD(P) binding site [chemical binding]; other site 1133849012970 active site 1133849012971 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 1133849012972 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1133849012973 active site 1133849012974 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1133849012975 Predicted transcriptional regulator [Transcription]; Region: COG2944 1133849012976 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1133849012977 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1133849012978 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1133849012979 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1133849012980 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1133849012981 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 1133849012982 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 1133849012983 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849012984 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849012985 active site 1133849012986 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1133849012987 NlpC/P60 family; Region: NLPC_P60; cl17555 1133849012988 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 1133849012989 AAA-like domain; Region: AAA_10; pfam12846 1133849012990 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849012991 Secretory lipase; Region: LIP; pfam03583 1133849012992 Cutinase; Region: Cutinase; pfam01083 1133849012993 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849012994 non-specific DNA binding site [nucleotide binding]; other site 1133849012995 salt bridge; other site 1133849012996 sequence-specific DNA binding site [nucleotide binding]; other site 1133849012997 NB-ARC domain; Region: NB-ARC; pfam00931 1133849012998 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1133849012999 binding surface 1133849013000 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849013001 TPR motif; other site 1133849013002 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849013003 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849013004 S-adenosylmethionine binding site [chemical binding]; other site 1133849013005 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1133849013006 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1133849013007 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1133849013008 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1133849013009 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1133849013010 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1133849013011 DNA binding residues [nucleotide binding] 1133849013012 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1133849013013 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1133849013014 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849013015 non-specific DNA binding site [nucleotide binding]; other site 1133849013016 salt bridge; other site 1133849013017 sequence-specific DNA binding site [nucleotide binding]; other site 1133849013018 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 1133849013019 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1133849013020 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 1133849013021 potential frameshift: common BLAST hit: gi|399539566|ref|YP_006552228.1| recombinase 1133849013022 PA14 domain; Region: PA14; cl08459 1133849013023 PA14 domain; Region: PA14; pfam07691 1133849013024 RHS Repeat; Region: RHS_repeat; cl11982 1133849013025 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1133849013026 Short C-terminal domain; Region: SHOCT; pfam09851 1133849013027 Colicin D; Region: Colicin_D; pfam11429 1133849013028 LGFP repeat; Region: LGFP; pfam08310 1133849013029 LGFP repeat; Region: LGFP; pfam08310 1133849013030 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849013031 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1133849013032 NAD(P) binding site [chemical binding]; other site 1133849013033 active site 1133849013034 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1133849013035 SnoaL-like domain; Region: SnoaL_4; pfam13577 1133849013036 Helix-turn-helix domain; Region: HTH_31; pfam13560 1133849013037 sequence-specific DNA binding site [nucleotide binding]; other site 1133849013038 salt bridge; other site 1133849013039 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1133849013040 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1133849013041 conserved cys residue [active] 1133849013042 putative transposase OrfB; Reviewed; Region: PHA02517 1133849013043 HTH-like domain; Region: HTH_21; pfam13276 1133849013044 Integrase core domain; Region: rve; pfam00665 1133849013045 Integrase core domain; Region: rve_3; pfam13683 1133849013046 Transposase; Region: HTH_Tnp_1; cl17663 1133849013047 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1133849013048 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1133849013049 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1133849013050 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849013051 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1133849013052 acyl-activating enzyme (AAE) consensus motif; other site 1133849013053 acyl-activating enzyme (AAE) consensus motif; other site 1133849013054 putative AMP binding site [chemical binding]; other site 1133849013055 putative active site [active] 1133849013056 putative CoA binding site [chemical binding]; other site 1133849013057 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1133849013058 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1133849013059 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1133849013060 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849013061 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849013062 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1133849013063 NAD(P) binding site [chemical binding]; other site 1133849013064 catalytic residues [active] 1133849013065 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1133849013066 Lipase (class 2); Region: Lipase_2; pfam01674 1133849013067 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1133849013068 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1133849013069 Lsr2; Region: Lsr2; pfam11774 1133849013070 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1133849013071 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1133849013072 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1133849013073 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1133849013074 conserved cys residue [active] 1133849013075 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849013076 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849013077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849013078 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1133849013079 putative substrate translocation pore; other site 1133849013080 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1133849013081 CoenzymeA binding site [chemical binding]; other site 1133849013082 subunit interaction site [polypeptide binding]; other site 1133849013083 PHB binding site; other site 1133849013084 Amidohydrolase; Region: Amidohydro_5; pfam13594 1133849013085 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1133849013086 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1133849013087 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 1133849013088 metal binding site [ion binding]; metal-binding site 1133849013089 putative dimer interface [polypeptide binding]; other site 1133849013090 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849013091 NmrA-like family; Region: NmrA; pfam05368 1133849013092 NAD(P) binding site [chemical binding]; other site 1133849013093 active site 1133849013094 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1133849013095 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1133849013096 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1133849013097 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1133849013098 substrate-cofactor binding pocket; other site 1133849013099 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849013100 catalytic residue [active] 1133849013101 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1133849013102 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1133849013103 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1133849013104 dimerization interface [polypeptide binding]; other site 1133849013105 substrate binding pocket [chemical binding]; other site 1133849013106 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849013107 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1133849013108 Helix-turn-helix domain; Region: HTH_18; pfam12833 1133849013109 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849013110 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849013111 Cytochrome P450; Region: p450; cl12078 1133849013112 H+ Antiporter protein; Region: 2A0121; TIGR00900 1133849013113 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1133849013114 hypothetical protein; Provisional; Region: PRK07236 1133849013115 hypothetical protein; Provisional; Region: PRK06184 1133849013116 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 1133849013117 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1133849013118 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1133849013119 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1133849013120 DNA-binding site [nucleotide binding]; DNA binding site 1133849013121 UTRA domain; Region: UTRA; pfam07702 1133849013122 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1133849013123 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1133849013124 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1133849013125 Walker A/P-loop; other site 1133849013126 ATP binding site [chemical binding]; other site 1133849013127 Q-loop/lid; other site 1133849013128 ABC transporter signature motif; other site 1133849013129 Walker B; other site 1133849013130 D-loop; other site 1133849013131 H-loop/switch region; other site 1133849013132 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1133849013133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849013134 dimer interface [polypeptide binding]; other site 1133849013135 conserved gate region; other site 1133849013136 putative PBP binding loops; other site 1133849013137 ABC-ATPase subunit interface; other site 1133849013138 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1133849013139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849013140 dimer interface [polypeptide binding]; other site 1133849013141 conserved gate region; other site 1133849013142 putative PBP binding loops; other site 1133849013143 ABC-ATPase subunit interface; other site 1133849013144 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 1133849013145 catalytic Zn binding site [ion binding]; other site 1133849013146 putative phosphonate catabolism associated alcohol dehydrogenase; Region: HpnZ_proposed; TIGR03366 1133849013147 structural Zn binding site [ion binding]; other site 1133849013148 tetramer interface [polypeptide binding]; other site 1133849013149 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849013150 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849013151 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1133849013152 Beta-lactamase; Region: Beta-lactamase; pfam00144 1133849013153 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1133849013154 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1133849013155 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1133849013156 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849013157 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849013158 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1133849013159 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849013160 S-adenosylmethionine binding site [chemical binding]; other site 1133849013161 Lsr2; Region: Lsr2; pfam11774 1133849013162 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849013163 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1133849013164 salt bridge; other site 1133849013165 non-specific DNA binding site [nucleotide binding]; other site 1133849013166 sequence-specific DNA binding site [nucleotide binding]; other site 1133849013167 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849013168 NmrA-like family; Region: NmrA; pfam05368 1133849013169 NAD(P) binding site [chemical binding]; other site 1133849013170 active site 1133849013171 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1133849013172 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1133849013173 Coenzyme A binding pocket [chemical binding]; other site 1133849013174 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1133849013175 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1133849013176 active site 1133849013177 catalytic tetrad [active] 1133849013178 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849013179 Condensation domain; Region: Condensation; pfam00668 1133849013180 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849013181 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849013182 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849013183 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1133849013184 acyl-activating enzyme (AAE) consensus motif; other site 1133849013185 AMP binding site [chemical binding]; other site 1133849013186 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849013187 Condensation domain; Region: Condensation; pfam00668 1133849013188 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1133849013189 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849013190 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1133849013191 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1133849013192 active site 1133849013193 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849013194 Thioesterase domain; Region: Thioesterase; pfam00975 1133849013195 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1133849013196 nucleophilic elbow; other site 1133849013197 catalytic triad; other site 1133849013198 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1133849013199 classical (c) SDRs; Region: SDR_c; cd05233 1133849013200 NAD(P) binding site [chemical binding]; other site 1133849013201 active site 1133849013202 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849013203 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1133849013204 acyl-activating enzyme (AAE) consensus motif; other site 1133849013205 AMP binding site [chemical binding]; other site 1133849013206 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849013207 major facilitator superfamily transporter; Provisional; Region: PRK05122 1133849013208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849013209 putative substrate translocation pore; other site 1133849013210 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1133849013211 Uncharacterized conserved protein [Function unknown]; Region: COG5276 1133849013212 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 1133849013213 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849013214 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 1133849013215 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1133849013216 putative NAD(P) binding site [chemical binding]; other site 1133849013217 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849013218 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1133849013219 motif 1; other site 1133849013220 dimer interface [polypeptide binding]; other site 1133849013221 active site 1133849013222 motif 2; other site 1133849013223 motif 3; other site 1133849013224 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849013225 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1133849013226 classical (c) SDRs; Region: SDR_c; cd05233 1133849013227 NAD(P) binding site [chemical binding]; other site 1133849013228 active site 1133849013229 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849013230 Walker A/P-loop; other site 1133849013231 ATP binding site [chemical binding]; other site 1133849013232 NACHT domain; Region: NACHT; pfam05729 1133849013233 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1133849013234 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1133849013235 heme binding site [chemical binding]; other site 1133849013236 ferroxidase pore; other site 1133849013237 ferroxidase diiron center [ion binding]; other site 1133849013238 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1133849013239 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1133849013240 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1133849013241 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849013242 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849013243 DNA binding residues [nucleotide binding] 1133849013244 dimerization interface [polypeptide binding]; other site 1133849013245 Transport protein; Region: actII; TIGR00833 1133849013246 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1133849013247 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 1133849013248 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 1133849013249 hypothetical protein; Provisional; Region: PRK07236 1133849013250 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1133849013251 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1133849013252 active site 1133849013253 FMN binding site [chemical binding]; other site 1133849013254 substrate binding site [chemical binding]; other site 1133849013255 homotetramer interface [polypeptide binding]; other site 1133849013256 catalytic residue [active] 1133849013257 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1133849013258 classical (c) SDRs; Region: SDR_c; cd05233 1133849013259 NAD(P) binding site [chemical binding]; other site 1133849013260 active site 1133849013261 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1133849013262 MarR family; Region: MarR; pfam01047 1133849013263 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1133849013264 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1133849013265 substrate binding site [chemical binding]; other site 1133849013266 oxyanion hole (OAH) forming residues; other site 1133849013267 trimer interface [polypeptide binding]; other site 1133849013268 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849013269 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849013270 active site 1133849013271 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849013272 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1133849013273 acyl-activating enzyme (AAE) consensus motif; other site 1133849013274 AMP binding site [chemical binding]; other site 1133849013275 active site 1133849013276 CoA binding site [chemical binding]; other site 1133849013277 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1133849013278 homotrimer interaction site [polypeptide binding]; other site 1133849013279 putative active site [active] 1133849013280 Cutinase; Region: Cutinase; pfam01083 1133849013281 CutC family; Region: CutC; cl01218 1133849013282 Cation efflux family; Region: Cation_efflux; cl00316 1133849013283 hypothetical protein; Provisional; Region: PRK07236 1133849013284 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1133849013285 putative metal binding site [ion binding]; other site 1133849013286 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1133849013287 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 1133849013288 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1133849013289 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1133849013290 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1133849013291 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1133849013292 intersubunit interface [polypeptide binding]; other site 1133849013293 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1133849013294 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1133849013295 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1133849013296 FAD binding pocket [chemical binding]; other site 1133849013297 FAD binding motif [chemical binding]; other site 1133849013298 phosphate binding motif [ion binding]; other site 1133849013299 NAD binding pocket [chemical binding]; other site 1133849013300 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 1133849013301 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1133849013302 intersubunit interface [polypeptide binding]; other site 1133849013303 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1133849013304 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1133849013305 Walker A/P-loop; other site 1133849013306 ATP binding site [chemical binding]; other site 1133849013307 Q-loop/lid; other site 1133849013308 ABC transporter signature motif; other site 1133849013309 Walker B; other site 1133849013310 D-loop; other site 1133849013311 H-loop/switch region; other site 1133849013312 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1133849013313 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1133849013314 ABC-ATPase subunit interface; other site 1133849013315 dimer interface [polypeptide binding]; other site 1133849013316 putative PBP binding regions; other site 1133849013317 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1133849013318 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1133849013319 ABC-ATPase subunit interface; other site 1133849013320 dimer interface [polypeptide binding]; other site 1133849013321 putative PBP binding regions; other site 1133849013322 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1133849013323 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849013324 TAP-like protein; Region: Abhydrolase_4; pfam08386 1133849013325 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1133849013326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849013327 putative substrate translocation pore; other site 1133849013328 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 1133849013329 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1133849013330 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849013331 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 1133849013332 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1133849013333 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1133849013334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849013335 dimer interface [polypeptide binding]; other site 1133849013336 conserved gate region; other site 1133849013337 putative PBP binding loops; other site 1133849013338 ABC-ATPase subunit interface; other site 1133849013339 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1133849013340 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849013341 dimer interface [polypeptide binding]; other site 1133849013342 conserved gate region; other site 1133849013343 putative PBP binding loops; other site 1133849013344 ABC-ATPase subunit interface; other site 1133849013345 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 1133849013346 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1133849013347 active site 1133849013348 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1133849013349 active site 1133849013350 ATP binding site [chemical binding]; other site 1133849013351 substrate binding site [chemical binding]; other site 1133849013352 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1133849013353 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1133849013354 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1133849013355 Phosphotransferase enzyme family; Region: APH; pfam01636 1133849013356 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1133849013357 Predicted transcriptional regulators [Transcription]; Region: COG1695 1133849013358 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1133849013359 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1133849013360 active site 1133849013361 metal binding site [ion binding]; metal-binding site 1133849013362 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849013363 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1133849013364 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1133849013365 Zinc carboxypeptidase; Region: Peptidase_M14; pfam00246 1133849013366 Zn binding site [ion binding]; other site 1133849013367 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1133849013368 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1133849013369 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1133849013370 putative acyl-acceptor binding pocket; other site 1133849013371 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1133849013372 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1133849013373 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849013374 Cytochrome P450; Region: p450; cl12078 1133849013375 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1133849013376 dimer interface [polypeptide binding]; other site 1133849013377 motif 1; other site 1133849013378 active site 1133849013379 motif 2; other site 1133849013380 motif 3; other site 1133849013381 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 1133849013382 hypothetical protein; Provisional; Region: PRK06834 1133849013383 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1133849013384 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1133849013385 General stress protein [General function prediction only]; Region: GsiB; COG3729 1133849013386 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1133849013387 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1133849013388 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1133849013389 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1133849013390 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 1133849013391 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1133849013392 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1133849013393 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1133849013394 amino acid permease (GABA permease); Region: 2A0304; TIGR00907 1133849013395 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1133849013396 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1133849013397 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1133849013398 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1133849013399 Lipase (class 2); Region: Lipase_2; pfam01674 1133849013400 Erythromycin esterase; Region: Erythro_esteras; pfam05139 1133849013401 First Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt1; cd04772 1133849013402 DNA binding residues [nucleotide binding] 1133849013403 putative dimer interface [polypeptide binding]; other site 1133849013404 Second Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt2; cd04773 1133849013405 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1133849013406 DNA binding residues [nucleotide binding] 1133849013407 putative dimer interface [polypeptide binding]; other site 1133849013408 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1133849013409 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849013410 active site 1133849013411 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1133849013412 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849013413 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849013414 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1133849013415 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1133849013416 active site 1133849013417 ATP binding site [chemical binding]; other site 1133849013418 substrate binding site [chemical binding]; other site 1133849013419 activation loop (A-loop); other site 1133849013420 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1133849013421 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 1133849013422 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1133849013423 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1133849013424 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 1133849013425 Ribosomal RNA adenine dimethylases; Region: rADc; smart00650 1133849013426 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 1133849013427 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1133849013428 putative active site [active] 1133849013429 putative substrate binding site [chemical binding]; other site 1133849013430 putative FMN binding site [chemical binding]; other site 1133849013431 putative catalytic residues [active] 1133849013432 acyl-CoA synthetase; Validated; Region: PRK07788 1133849013433 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849013434 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849013435 acyl-activating enzyme (AAE) consensus motif; other site 1133849013436 AMP binding site [chemical binding]; other site 1133849013437 active site 1133849013438 CoA binding site [chemical binding]; other site 1133849013439 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1133849013440 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 1133849013441 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 1133849013442 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1133849013443 inhibitor-cofactor binding pocket; inhibition site 1133849013444 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849013445 catalytic residue [active] 1133849013446 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1133849013447 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1133849013448 Coenzyme A binding pocket [chemical binding]; other site 1133849013449 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1133849013450 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1133849013451 dimerization interface [polypeptide binding]; other site 1133849013452 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1133849013453 dimer interface [polypeptide binding]; other site 1133849013454 phosphorylation site [posttranslational modification] 1133849013455 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849013456 ATP binding site [chemical binding]; other site 1133849013457 G-X-G motif; other site 1133849013458 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1133849013459 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849013460 active site 1133849013461 phosphorylation site [posttranslational modification] 1133849013462 intermolecular recognition site; other site 1133849013463 dimerization interface [polypeptide binding]; other site 1133849013464 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1133849013465 DNA binding site [nucleotide binding] 1133849013466 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 1133849013467 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849013468 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1133849013469 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1133849013470 DNA binding residues [nucleotide binding] 1133849013471 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1133849013472 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1133849013473 PAS fold; Region: PAS_3; pfam08447 1133849013474 putative active site [active] 1133849013475 heme pocket [chemical binding]; other site 1133849013476 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1133849013477 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1133849013478 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1133849013479 anti sigma factor interaction site; other site 1133849013480 regulatory phosphorylation site [posttranslational modification]; other site 1133849013481 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1133849013482 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1133849013483 putative ADP-binding pocket [chemical binding]; other site 1133849013484 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1133849013485 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1133849013486 potential frameshift: common BLAST hit: gi|145223728|ref|YP_001134406.1| peptidase S58, DmpA 1133849013487 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1133849013488 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1133849013489 iron-sulfur cluster [ion binding]; other site 1133849013490 [2Fe-2S] cluster binding site [ion binding]; other site 1133849013491 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1133849013492 active site 1133849013493 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1133849013494 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1133849013495 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 1133849013496 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1133849013497 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1133849013498 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1133849013499 phosphopeptide binding site; other site 1133849013500 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1133849013501 metal ion-dependent adhesion site (MIDAS); other site 1133849013502 Double zinc ribbon; Region: DZR; pfam12773 1133849013503 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 1133849013504 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1133849013505 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1133849013506 active site 1133849013507 ATP binding site [chemical binding]; other site 1133849013508 substrate binding site [chemical binding]; other site 1133849013509 activation loop (A-loop); other site 1133849013510 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1133849013511 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1133849013512 substrate binding pocket [chemical binding]; other site 1133849013513 membrane-bound complex binding site; other site 1133849013514 hinge residues; other site 1133849013515 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1133849013516 Helix-turn-helix domain; Region: HTH_18; pfam12833 1133849013517 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849013518 TAP-like protein; Region: Abhydrolase_4; pfam08386 1133849013519 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1133849013520 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1133849013521 Beta-lactamase; Region: Beta-lactamase; pfam00144 1133849013522 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1133849013523 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1133849013524 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1133849013525 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1133849013526 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1133849013527 carboxyltransferase (CT) interaction site; other site 1133849013528 biotinylation site [posttranslational modification]; other site 1133849013529 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1133849013530 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1133849013531 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1133849013532 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1133849013533 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849013534 dimer interface [polypeptide binding]; other site 1133849013535 conserved gate region; other site 1133849013536 putative PBP binding loops; other site 1133849013537 ABC-ATPase subunit interface; other site 1133849013538 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849013539 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 1133849013540 Walker A/P-loop; other site 1133849013541 ATP binding site [chemical binding]; other site 1133849013542 Q-loop/lid; other site 1133849013543 ABC transporter signature motif; other site 1133849013544 Walker B; other site 1133849013545 D-loop; other site 1133849013546 H-loop/switch region; other site 1133849013547 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1133849013548 substrate binding pocket [chemical binding]; other site 1133849013549 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1133849013550 membrane-bound complex binding site; other site 1133849013551 hinge residues; other site 1133849013552 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1133849013553 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1133849013554 active site 1133849013555 dimer interface [polypeptide binding]; other site 1133849013556 non-prolyl cis peptide bond; other site 1133849013557 insertion regions; other site 1133849013558 amino acid transporter; Region: 2A0306; TIGR00909 1133849013559 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1133849013560 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1133849013561 SnoaL-like domain; Region: SnoaL_3; pfam13474 1133849013562 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1133849013563 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1133849013564 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1133849013565 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1133849013566 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1133849013567 AsnC family; Region: AsnC_trans_reg; pfam01037 1133849013568 EF-hand domain pair; Region: EF_hand_5; pfam13499 1133849013569 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 1133849013570 Ca2+ binding site [ion binding]; other site 1133849013571 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1133849013572 hydrophobic ligand binding site; other site 1133849013573 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1133849013574 putative hydrophobic ligand binding site [chemical binding]; other site 1133849013575 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1133849013576 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1133849013577 FAD binding pocket [chemical binding]; other site 1133849013578 FAD binding motif [chemical binding]; other site 1133849013579 phosphate binding motif [ion binding]; other site 1133849013580 NAD binding pocket [chemical binding]; other site 1133849013581 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1133849013582 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1133849013583 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849013584 NAD(P) binding site [chemical binding]; other site 1133849013585 active site 1133849013586 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849013587 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1133849013588 NAD(P) binding site [chemical binding]; other site 1133849013589 active site 1133849013590 Helix-turn-helix domain; Region: HTH_31; pfam13560 1133849013591 salt bridge; other site 1133849013592 non-specific DNA binding site [nucleotide binding]; other site 1133849013593 sequence-specific DNA binding site [nucleotide binding]; other site 1133849013594 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849013595 Walker A/P-loop; other site 1133849013596 ATP binding site [chemical binding]; other site 1133849013597 Q-loop/lid; other site 1133849013598 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1133849013599 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1133849013600 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849013601 Walker A/P-loop; other site 1133849013602 ATP binding site [chemical binding]; other site 1133849013603 Q-loop/lid; other site 1133849013604 ABC transporter signature motif; other site 1133849013605 Walker B; other site 1133849013606 D-loop; other site 1133849013607 H-loop/switch region; other site 1133849013608 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 1133849013609 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1133849013610 SnoaL-like domain; Region: SnoaL_2; pfam12680 1133849013611 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1133849013612 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 1133849013613 Protein of unknown function (DUF419); Region: DUF419; cl15265 1133849013614 YcjX-like family, DUF463; Region: DUF463; cl01193 1133849013615 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1133849013616 DNA binding site [nucleotide binding] 1133849013617 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1133849013618 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1133849013619 NAD(P) binding site [chemical binding]; other site 1133849013620 catalytic residues [active] 1133849013621 Protein of unknown function (DUF779); Region: DUF779; cl01432 1133849013622 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 1133849013623 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 1133849013624 NAD(P) binding site [chemical binding]; other site 1133849013625 catalytic residues [active] 1133849013626 Nitrate and nitrite sensing; Region: NIT; pfam08376 1133849013627 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849013628 ATP binding site [chemical binding]; other site 1133849013629 Mg2+ binding site [ion binding]; other site 1133849013630 G-X-G motif; other site 1133849013631 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 1133849013632 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1133849013633 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1133849013634 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1133849013635 G1 box; other site 1133849013636 GTP/Mg2+ binding site [chemical binding]; other site 1133849013637 G2 box; other site 1133849013638 Switch I region; other site 1133849013639 G3 box; other site 1133849013640 Switch II region; other site 1133849013641 G4 box; other site 1133849013642 G5 box; other site 1133849013643 Phosphotransferase enzyme family; Region: APH; pfam01636 1133849013644 Fructosamine kinase; Region: Fructosamin_kin; cl17579 1133849013645 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849013646 sequence-specific DNA binding site [nucleotide binding]; other site 1133849013647 salt bridge; other site 1133849013648 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1133849013649 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1133849013650 putative active site [active] 1133849013651 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1133849013652 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849013653 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1133849013654 ABC1 family; Region: ABC1; pfam03109 1133849013655 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1133849013656 active site 1133849013657 ATP binding site [chemical binding]; other site 1133849013658 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1133849013659 hypothetical protein; Provisional; Region: PRK07236 1133849013660 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1133849013661 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1133849013662 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1133849013663 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1133849013664 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 1133849013665 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 1133849013666 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1133849013667 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1133849013668 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1133849013669 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1133849013670 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1133849013671 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 1133849013672 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1133849013673 inhibitor-cofactor binding pocket; inhibition site 1133849013674 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849013675 catalytic residue [active] 1133849013676 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1133849013677 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1133849013678 dimer interface [polypeptide binding]; other site 1133849013679 active site 1133849013680 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1133849013681 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1133849013682 dimer interface [polypeptide binding]; other site 1133849013683 active site 1133849013684 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1133849013685 active site 2 [active] 1133849013686 active site 1 [active] 1133849013687 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1133849013688 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1133849013689 dimer interface [polypeptide binding]; other site 1133849013690 active site 1133849013691 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1133849013692 B12 binding site [chemical binding]; other site 1133849013693 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1133849013694 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1133849013695 FeS/SAM binding site; other site 1133849013696 Phosphopantetheinyl transferase (holo-ACP synthase) [Lipid metabolism]; Region: AcpS; COG0736 1133849013697 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1133849013698 classical (c) SDRs; Region: SDR_c; cd05233 1133849013699 NAD(P) binding site [chemical binding]; other site 1133849013700 active site 1133849013701 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1133849013702 active site 2 [active] 1133849013703 active site 1 [active] 1133849013704 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1133849013705 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1133849013706 active site 1133849013707 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 1133849013708 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 1133849013709 putative NAD(P) binding site [chemical binding]; other site 1133849013710 active site 1133849013711 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1133849013712 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849013713 S-adenosylmethionine binding site [chemical binding]; other site 1133849013714 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1133849013715 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1133849013716 Walker A/P-loop; other site 1133849013717 ATP binding site [chemical binding]; other site 1133849013718 Q-loop/lid; other site 1133849013719 ABC transporter signature motif; other site 1133849013720 Walker B; other site 1133849013721 D-loop; other site 1133849013722 H-loop/switch region; other site 1133849013723 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1133849013724 FtsX-like permease family; Region: FtsX; pfam02687 1133849013725 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1133849013726 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849013727 NAD(P) binding site [chemical binding]; other site 1133849013728 active site 1133849013729 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849013730 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849013731 active site 1133849013732 intermolecular recognition site; other site 1133849013733 dimerization interface [polypeptide binding]; other site 1133849013734 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849013735 DNA binding residues [nucleotide binding] 1133849013736 dimerization interface [polypeptide binding]; other site 1133849013737 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1133849013738 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849013739 catalytic residue [active] 1133849013740 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1133849013741 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1133849013742 Moco binding site; other site 1133849013743 metal coordination site [ion binding]; other site 1133849013744 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1133849013745 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 1133849013746 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849013747 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1133849013748 DNA binding residues [nucleotide binding] 1133849013749 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1133849013750 Fasciclin domain; Region: Fasciclin; pfam02469 1133849013751 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1133849013752 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1133849013753 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1133849013754 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1133849013755 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1133849013756 carboxyltransferase (CT) interaction site; other site 1133849013757 biotinylation site [posttranslational modification]; other site 1133849013758 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 1133849013759 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1133849013760 Predicted ATPase [General function prediction only]; Region: COG3903 1133849013761 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1133849013762 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1133849013763 TPR motif; other site 1133849013764 binding surface 1133849013765 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1133849013766 active site 1133849013767 catalytic triad [active] 1133849013768 oxyanion hole [active] 1133849013769 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 1133849013770 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1133849013771 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1133849013772 DNA binding residues [nucleotide binding] 1133849013773 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 1133849013774 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1133849013775 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1133849013776 dimerization interface [polypeptide binding]; other site 1133849013777 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1133849013778 dimer interface [polypeptide binding]; other site 1133849013779 phosphorylation site [posttranslational modification] 1133849013780 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849013781 ATP binding site [chemical binding]; other site 1133849013782 Mg2+ binding site [ion binding]; other site 1133849013783 G-X-G motif; other site 1133849013784 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1133849013785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849013786 active site 1133849013787 phosphorylation site [posttranslational modification] 1133849013788 intermolecular recognition site; other site 1133849013789 dimerization interface [polypeptide binding]; other site 1133849013790 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1133849013791 DNA binding site [nucleotide binding] 1133849013792 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1133849013793 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1133849013794 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1133849013795 Ricin-type beta-trefoil; Region: RICIN; smart00458 1133849013796 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1133849013797 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1133849013798 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849013799 Protein of unknown function (DUF461); Region: DUF461; pfam04314 1133849013800 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1133849013801 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1133849013802 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849013803 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1133849013804 dimer interface [polypeptide binding]; other site 1133849013805 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1133849013806 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1133849013807 putative active site [active] 1133849013808 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849013809 putative DNA binding site [nucleotide binding]; other site 1133849013810 putative Zn2+ binding site [ion binding]; other site 1133849013811 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1133849013812 Peptidase family M23; Region: Peptidase_M23; pfam01551 1133849013813 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1133849013814 Flavoprotein; Region: Flavoprotein; cl08021 1133849013815 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1133849013816 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1133849013817 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849013818 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1133849013819 Walker A/P-loop; other site 1133849013820 ATP binding site [chemical binding]; other site 1133849013821 Q-loop/lid; other site 1133849013822 ABC transporter signature motif; other site 1133849013823 Walker B; other site 1133849013824 D-loop; other site 1133849013825 H-loop/switch region; other site 1133849013826 Condensation domain; Region: Condensation; pfam00668 1133849013827 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849013828 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1133849013829 acyl-activating enzyme (AAE) consensus motif; other site 1133849013830 AMP binding site [chemical binding]; other site 1133849013831 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849013832 Condensation domain; Region: Condensation; pfam00668 1133849013833 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849013834 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849013835 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849013836 acyl-activating enzyme (AAE) consensus motif; other site 1133849013837 AMP binding site [chemical binding]; other site 1133849013838 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849013839 Condensation domain; Region: Condensation; pfam00668 1133849013840 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849013841 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849013842 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849013843 acyl-activating enzyme (AAE) consensus motif; other site 1133849013844 AMP binding site [chemical binding]; other site 1133849013845 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849013846 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1133849013847 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849013848 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849013849 acyl-activating enzyme (AAE) consensus motif; other site 1133849013850 AMP binding site [chemical binding]; other site 1133849013851 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849013852 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1133849013853 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1133849013854 putative active site [active] 1133849013855 catalytic triad [active] 1133849013856 putative dimer interface [polypeptide binding]; other site 1133849013857 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1133849013858 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1133849013859 active site 1133849013860 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1133849013861 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1133849013862 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1133849013863 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849013864 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849013865 active site 1133849013866 phosphorylation site [posttranslational modification] 1133849013867 intermolecular recognition site; other site 1133849013868 dimerization interface [polypeptide binding]; other site 1133849013869 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849013870 DNA binding residues [nucleotide binding] 1133849013871 dimerization interface [polypeptide binding]; other site 1133849013872 Histidine kinase; Region: HisKA_3; pfam07730 1133849013873 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1133849013874 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1133849013875 hypothetical protein; Provisional; Region: PRK10621 1133849013876 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849013877 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1133849013878 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1133849013879 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 1133849013880 Predicted transcriptional regulators [Transcription]; Region: COG1695 1133849013881 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1133849013882 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1133849013883 active site 1133849013884 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1133849013885 active site 1133849013886 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 1133849013887 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1133849013888 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849013889 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849013890 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849013891 enoyl-CoA hydratase; Provisional; Region: PRK08260 1133849013892 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1133849013893 substrate binding site [chemical binding]; other site 1133849013894 oxyanion hole (OAH) forming residues; other site 1133849013895 trimer interface [polypeptide binding]; other site 1133849013896 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1133849013897 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1133849013898 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1133849013899 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1133849013900 Coenzyme A binding pocket [chemical binding]; other site 1133849013901 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1133849013902 active site 1133849013903 metal binding site [ion binding]; metal-binding site 1133849013904 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849013905 Isochorismatase family; Region: Isochorismatase; pfam00857 1133849013906 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1133849013907 catalytic triad [active] 1133849013908 conserved cis-peptide bond; other site 1133849013909 Predicted membrane protein [Function unknown]; Region: COG2246 1133849013910 GtrA-like protein; Region: GtrA; pfam04138 1133849013911 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1133849013912 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1133849013913 HTH domain; Region: HTH_11; pfam08279 1133849013914 Predicted transcriptional regulator [Transcription]; Region: COG2378 1133849013915 WYL domain; Region: WYL; pfam13280 1133849013916 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1133849013917 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1133849013918 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1133849013919 SnoaL-like domain; Region: SnoaL_4; pfam13577 1133849013920 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1133849013921 precorrin-3B synthase; Region: CobG; TIGR02435 1133849013922 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1133849013923 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1133849013924 nudix motif; other site 1133849013925 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1133849013926 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1133849013927 inhibitor-cofactor binding pocket; inhibition site 1133849013928 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849013929 catalytic residue [active] 1133849013930 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1133849013931 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1133849013932 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1133849013933 Phosphotransferase enzyme family; Region: APH; pfam01636 1133849013934 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1133849013935 active site 1133849013936 ATP binding site [chemical binding]; other site 1133849013937 substrate binding site [chemical binding]; other site 1133849013938 Amidinotransferase; Region: Amidinotransf; cl12043 1133849013939 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1133849013940 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1133849013941 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1133849013942 AsnC family; Region: AsnC_trans_reg; pfam01037 1133849013943 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1133849013944 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1133849013945 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1133849013946 active site 1133849013947 SAM binding site [chemical binding]; other site 1133849013948 homodimer interface [polypeptide binding]; other site 1133849013949 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1133849013950 active site 1133849013951 SAM binding site [chemical binding]; other site 1133849013952 homodimer interface [polypeptide binding]; other site 1133849013953 Predicted transcriptional regulators [Transcription]; Region: COG1695 1133849013954 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1133849013955 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1133849013956 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 1133849013957 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1133849013958 active site 1133849013959 putative homodimer interface [polypeptide binding]; other site 1133849013960 SAM binding site [chemical binding]; other site 1133849013961 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1133849013962 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849013963 S-adenosylmethionine binding site [chemical binding]; other site 1133849013964 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849013965 short chain dehydrogenase; Provisional; Region: PRK08251 1133849013966 NAD(P) binding site [chemical binding]; other site 1133849013967 active site 1133849013968 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1133849013969 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1133849013970 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1133849013971 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 1133849013972 active site 1133849013973 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849013974 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849013975 Secretory lipase; Region: LIP; pfam03583 1133849013976 acyl-CoA synthetase; Validated; Region: PRK07788 1133849013977 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849013978 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849013979 acyl-activating enzyme (AAE) consensus motif; other site 1133849013980 acyl-activating enzyme (AAE) consensus motif; other site 1133849013981 AMP binding site [chemical binding]; other site 1133849013982 active site 1133849013983 CoA binding site [chemical binding]; other site 1133849013984 classical (c) SDRs; Region: SDR_c; cd05233 1133849013985 NAD(P) binding site [chemical binding]; other site 1133849013986 active site 1133849013987 5'-3' exonuclease; Region: 53EXOc; smart00475 1133849013988 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1133849013989 active site 1133849013990 metal binding site 1 [ion binding]; metal-binding site 1133849013991 putative 5' ssDNA interaction site; other site 1133849013992 metal binding site 3; metal-binding site 1133849013993 metal binding site 2 [ion binding]; metal-binding site 1133849013994 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1133849013995 putative DNA binding site [nucleotide binding]; other site 1133849013996 putative metal binding site [ion binding]; other site 1133849013997 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1133849013998 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 1133849013999 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1133849014000 ATP binding site [chemical binding]; other site 1133849014001 putative Mg++ binding site [ion binding]; other site 1133849014002 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1133849014003 ATP-binding site [chemical binding]; other site 1133849014004 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1133849014005 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1133849014006 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1133849014007 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 1133849014008 2-dehydropantoate 2-reductase; Provisional; Region: PRK08229 1133849014009 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1133849014010 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1133849014011 Predicted transcriptional regulator [Transcription]; Region: COG2378 1133849014012 WYL domain; Region: WYL; pfam13280 1133849014013 Predicted transcriptional regulator [Transcription]; Region: COG2378 1133849014014 WYL domain; Region: WYL; pfam13280 1133849014015 Domain of unknown function DUF77; Region: DUF77; pfam01910 1133849014016 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 1133849014017 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 1133849014018 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1133849014019 active site 1133849014020 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 1133849014021 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1133849014022 active site 1133849014023 Pup-like protein; Region: Pup; cl05289 1133849014024 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 1133849014025 Predicted membrane protein [Function unknown]; Region: COG2311 1133849014026 Protein of unknown function (DUF418); Region: DUF418; cl12135 1133849014027 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1133849014028 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849014029 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849014030 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1133849014031 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1133849014032 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1133849014033 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1133849014034 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849014035 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1133849014036 acyl-activating enzyme (AAE) consensus motif; other site 1133849014037 acyl-activating enzyme (AAE) consensus motif; other site 1133849014038 putative AMP binding site [chemical binding]; other site 1133849014039 putative active site [active] 1133849014040 putative CoA binding site [chemical binding]; other site 1133849014041 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1133849014042 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1133849014043 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1133849014044 Condensation domain; Region: Condensation; pfam00668 1133849014045 Condensation domain; Region: Condensation; pfam00668 1133849014046 Condensation domain; Region: Condensation; pfam00668 1133849014047 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 1133849014048 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1133849014049 Domain of unknown function (DUF385); Region: DUF385; cl04387 1133849014050 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 1133849014051 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1133849014052 nudix motif; other site 1133849014053 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 1133849014054 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1133849014055 ArsC family; Region: ArsC; pfam03960 1133849014056 catalytic residues [active] 1133849014057 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1133849014058 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1133849014059 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1133849014060 hypothetical protein; Provisional; Region: PRK06062 1133849014061 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1133849014062 inhibitor-cofactor binding pocket; inhibition site 1133849014063 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849014064 catalytic residue [active] 1133849014065 NMT1/THI5 like; Region: NMT1; pfam09084 1133849014066 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 1133849014067 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1133849014068 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1133849014069 Walker A/P-loop; other site 1133849014070 ATP binding site [chemical binding]; other site 1133849014071 Q-loop/lid; other site 1133849014072 ABC transporter signature motif; other site 1133849014073 Walker B; other site 1133849014074 D-loop; other site 1133849014075 H-loop/switch region; other site 1133849014076 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 1133849014077 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1133849014078 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 1133849014079 phenylhydantoinase; Validated; Region: PRK08323 1133849014080 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 1133849014081 tetramer interface [polypeptide binding]; other site 1133849014082 active site 1133849014083 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1133849014084 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 1133849014085 active site 1133849014086 catalytic triad [active] 1133849014087 dimer interface [polypeptide binding]; other site 1133849014088 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1133849014089 DNA-binding site [nucleotide binding]; DNA binding site 1133849014090 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1133849014091 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1133849014092 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849014093 homodimer interface [polypeptide binding]; other site 1133849014094 catalytic residue [active] 1133849014095 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1133849014096 active site 1133849014097 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849014098 S-adenosylmethionine binding site [chemical binding]; other site 1133849014099 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1133849014100 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849014101 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1133849014102 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1133849014103 substrate binding pocket [chemical binding]; other site 1133849014104 catalytic triad [active] 1133849014105 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1133849014106 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 1133849014107 proteasome ATPase; Region: pup_AAA; TIGR03689 1133849014108 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1133849014109 Walker A motif; other site 1133849014110 ATP binding site [chemical binding]; other site 1133849014111 Walker B motif; other site 1133849014112 arginine finger; other site 1133849014113 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1133849014114 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849014115 S-adenosylmethionine binding site [chemical binding]; other site 1133849014116 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1133849014117 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1133849014118 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1133849014119 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1133849014120 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1133849014121 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1133849014122 homodimer interface [polypeptide binding]; other site 1133849014123 putative metal binding site [ion binding]; other site 1133849014124 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1133849014125 FMN binding site [chemical binding]; other site 1133849014126 substrate binding site [chemical binding]; other site 1133849014127 putative catalytic residue [active] 1133849014128 Choline/Carnitine o-acyltransferase; Region: Carn_acyltransf; pfam00755 1133849014129 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1133849014130 LGFP repeat; Region: LGFP; pfam08310 1133849014131 LGFP repeat; Region: LGFP; pfam08310 1133849014132 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 1133849014133 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1133849014134 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1133849014135 Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350 1133849014136 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1133849014137 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1133849014138 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1133849014139 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1133849014140 putative NAD(P) binding site [chemical binding]; other site 1133849014141 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1133849014142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1133849014143 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1133849014144 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1133849014145 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1133849014146 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1133849014147 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849014148 Walker A/P-loop; other site 1133849014149 ATP binding site [chemical binding]; other site 1133849014150 Q-loop/lid; other site 1133849014151 ABC transporter signature motif; other site 1133849014152 Walker B; other site 1133849014153 D-loop; other site 1133849014154 H-loop/switch region; other site 1133849014155 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1133849014156 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1133849014157 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1133849014158 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1133849014159 active site pocket [active] 1133849014160 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 1133849014161 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1133849014162 NAD(P) binding site [chemical binding]; other site 1133849014163 catalytic residues [active] 1133849014164 sulfopyruvate decarboxylase, beta subunit; Region: sulfopy_beta; TIGR03846 1133849014165 Thiamine pyrophosphate (TPP) family, ComE and PpyrDC subfamily, TPP-binding module; composed of proteins similar to sulfopyruvate decarboxylase beta subunit (ComE) and phosphonopyruvate decarboxylase (Ppyr decarboxylase). Methanococcus jannaschii...; Region: TPP_ComE_PpyrDC; cd02001 1133849014166 TPP-binding site [chemical binding]; other site 1133849014167 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1133849014168 PYR/PP interface [polypeptide binding]; other site 1133849014169 dimer interface [polypeptide binding]; other site 1133849014170 TPP binding site [chemical binding]; other site 1133849014171 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1133849014172 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1133849014173 DNA-binding site [nucleotide binding]; DNA binding site 1133849014174 FCD domain; Region: FCD; pfam07729 1133849014175 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1133849014176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849014177 putative substrate translocation pore; other site 1133849014178 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 1133849014179 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1133849014180 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1133849014181 homodimer interface [polypeptide binding]; other site 1133849014182 NADP binding site [chemical binding]; other site 1133849014183 substrate binding site [chemical binding]; other site 1133849014184 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1133849014185 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1133849014186 putative active site [active] 1133849014187 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1133849014188 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1133849014189 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1133849014190 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849014191 NAD(P) binding site [chemical binding]; other site 1133849014192 active site 1133849014193 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 1133849014194 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 1133849014195 NAD(P) binding site [chemical binding]; other site 1133849014196 catalytic residues [active] 1133849014197 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849014198 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849014199 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1133849014200 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1133849014201 FMN-binding pocket [chemical binding]; other site 1133849014202 flavin binding motif; other site 1133849014203 phosphate binding motif [ion binding]; other site 1133849014204 beta-alpha-beta structure motif; other site 1133849014205 NAD binding pocket [chemical binding]; other site 1133849014206 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849014207 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 1133849014208 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1133849014209 active site 1133849014210 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1133849014211 active site 1133849014212 peptide synthase; Provisional; Region: PRK09274 1133849014213 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_1; cd05910 1133849014214 acyl-activating enzyme (AAE) consensus motif; other site 1133849014215 putative AMP binding site [chemical binding]; other site 1133849014216 putative active site [active] 1133849014217 putative CoA binding site [chemical binding]; other site 1133849014218 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849014219 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 1133849014220 NAD(P) binding site [chemical binding]; other site 1133849014221 active site 1133849014222 MMPL family; Region: MMPL; pfam03176 1133849014223 MMPL family; Region: MMPL; pfam03176 1133849014224 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1133849014225 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1133849014226 active site 1133849014227 NTP binding site [chemical binding]; other site 1133849014228 metal binding triad [ion binding]; metal-binding site 1133849014229 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1133849014230 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1133849014231 putative di-iron ligands [ion binding]; other site 1133849014232 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849014233 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1133849014234 NAD(P) binding site [chemical binding]; other site 1133849014235 active site 1133849014236 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 1133849014237 active site 1133849014238 Zn binding site [ion binding]; other site 1133849014239 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1133849014240 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1133849014241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849014242 putative substrate translocation pore; other site 1133849014243 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1133849014244 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1133849014245 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1133849014246 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 1133849014247 putative substrate binding pocket [chemical binding]; other site 1133849014248 putative dimerization interface [polypeptide binding]; other site 1133849014249 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1133849014250 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1133849014251 DNA-binding site [nucleotide binding]; DNA binding site 1133849014252 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1133849014253 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849014254 homodimer interface [polypeptide binding]; other site 1133849014255 catalytic residue [active] 1133849014256 Putative amidotransferase; Region: DUF4066; pfam13278 1133849014257 conserved cys residue [active] 1133849014258 prolyl-tRNA synthetase; Provisional; Region: PRK08661 1133849014259 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 1133849014260 dimer interface [polypeptide binding]; other site 1133849014261 motif 1; other site 1133849014262 active site 1133849014263 motif 2; other site 1133849014264 motif 3; other site 1133849014265 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 1133849014266 anticodon binding site; other site 1133849014267 zinc-binding site [ion binding]; other site 1133849014268 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1133849014269 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1133849014270 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1133849014271 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1133849014272 conserved cys residue [active] 1133849014273 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849014274 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849014275 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 1133849014276 SnoaL-like domain; Region: SnoaL_3; pfam13474 1133849014277 TAP-like protein; Region: Abhydrolase_4; pfam08386 1133849014278 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849014279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849014280 active site 1133849014281 phosphorylation site [posttranslational modification] 1133849014282 intermolecular recognition site; other site 1133849014283 dimerization interface [polypeptide binding]; other site 1133849014284 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849014285 DNA binding residues [nucleotide binding] 1133849014286 dimerization interface [polypeptide binding]; other site 1133849014287 Histidine kinase; Region: HisKA_3; pfam07730 1133849014288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849014289 ATP binding site [chemical binding]; other site 1133849014290 Mg2+ binding site [ion binding]; other site 1133849014291 G-X-G motif; other site 1133849014292 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849014293 non-specific DNA binding site [nucleotide binding]; other site 1133849014294 salt bridge; other site 1133849014295 sequence-specific DNA binding site [nucleotide binding]; other site 1133849014296 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 1133849014297 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1133849014298 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1133849014299 active site 1133849014300 ATP binding site [chemical binding]; other site 1133849014301 substrate binding site [chemical binding]; other site 1133849014302 activation loop (A-loop); other site 1133849014303 short chain dehydrogenase; Provisional; Region: PRK08263 1133849014304 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1133849014305 NADP binding site [chemical binding]; other site 1133849014306 active site 1133849014307 steroid binding site; other site 1133849014308 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1133849014309 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1133849014310 metal binding site [ion binding]; metal-binding site 1133849014311 active site 1133849014312 I-site; other site 1133849014313 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1133849014314 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 1133849014315 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849014316 Cytochrome P450; Region: p450; cl12078 1133849014317 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849014318 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849014319 Predicted esterase [General function prediction only]; Region: COG0627 1133849014320 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1133849014321 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1133849014322 active site 1133849014323 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1133849014324 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 1133849014325 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1133849014326 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1133849014327 DNA binding site [nucleotide binding] 1133849014328 active site 1133849014329 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1133849014330 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849014331 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1133849014332 DNA binding residues [nucleotide binding] 1133849014333 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1133849014334 AAA domain; Region: AAA_30; pfam13604 1133849014335 Family description; Region: UvrD_C_2; pfam13538 1133849014336 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 1133849014337 Part of AAA domain; Region: AAA_19; pfam13245 1133849014338 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1133849014339 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 1133849014340 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1133849014341 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1133849014342 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1133849014343 metal binding site [ion binding]; metal-binding site 1133849014344 active site 1133849014345 I-site; other site 1133849014346 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1133849014347 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849014348 Cytochrome P450; Region: p450; cl12078 1133849014349 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1133849014350 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1133849014351 UreD urease accessory protein; Region: UreD; cl00530 1133849014352 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1133849014353 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1133849014354 short chain dehydrogenase; Provisional; Region: PRK05866 1133849014355 classical (c) SDRs; Region: SDR_c; cd05233 1133849014356 NAD(P) binding site [chemical binding]; other site 1133849014357 active site 1133849014358 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1133849014359 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849014360 putative substrate translocation pore; other site 1133849014361 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849014362 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849014363 Possible enoyl reductase; Region: MDR_enoyl_red; cd08244 1133849014364 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1133849014365 putative NAD(P) binding site [chemical binding]; other site 1133849014366 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1133849014367 active site 1133849014368 catalytic site [active] 1133849014369 substrate binding site [chemical binding]; other site 1133849014370 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1133849014371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849014372 S-adenosylmethionine binding site [chemical binding]; other site 1133849014373 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849014374 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1133849014375 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1133849014376 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1133849014377 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1133849014378 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1133849014379 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1133849014380 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 1133849014381 active site 1133849014382 substrate binding sites [chemical binding]; other site 1133849014383 ferrochelatase; Reviewed; Region: hemH; PRK00035 1133849014384 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1133849014385 C-terminal domain interface [polypeptide binding]; other site 1133849014386 active site 1133849014387 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1133849014388 active site 1133849014389 N-terminal domain interface [polypeptide binding]; other site 1133849014390 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 1133849014391 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849014392 NAD(P) binding site [chemical binding]; other site 1133849014393 active site 1133849014394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849014395 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1133849014396 NAD(P) binding site [chemical binding]; other site 1133849014397 active site 1133849014398 hypothetical protein; Provisional; Region: PRK13685 1133849014399 Aerotolerance regulator N-terminal; Region: BatA; cl06567 1133849014400 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1133849014401 metal ion-dependent adhesion site (MIDAS); other site 1133849014402 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1133849014403 Protein of unknown function DUF58; Region: DUF58; pfam01882 1133849014404 MoxR-like ATPases [General function prediction only]; Region: COG0714 1133849014405 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1133849014406 Walker A motif; other site 1133849014407 ATP binding site [chemical binding]; other site 1133849014408 Walker B motif; other site 1133849014409 arginine finger; other site 1133849014410 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1133849014411 NlpC/P60 family; Region: NLPC_P60; pfam00877 1133849014412 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1133849014413 aconitate hydratase; Validated; Region: PRK09277 1133849014414 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1133849014415 substrate binding site [chemical binding]; other site 1133849014416 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1133849014417 ligand binding site [chemical binding]; other site 1133849014418 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1133849014419 substrate binding site [chemical binding]; other site 1133849014420 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849014421 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849014422 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1133849014423 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849014424 NAD(P) binding site [chemical binding]; other site 1133849014425 active site 1133849014426 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1133849014427 active site 1133849014428 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; COG2082 1133849014429 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 1133849014430 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1133849014431 RibD C-terminal domain; Region: RibD_C; cl17279 1133849014432 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1133849014433 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1133849014434 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1133849014435 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849014436 Walker A/P-loop; other site 1133849014437 ATP binding site [chemical binding]; other site 1133849014438 Q-loop/lid; other site 1133849014439 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1133849014440 ABC transporter signature motif; other site 1133849014441 Walker B; other site 1133849014442 D-loop; other site 1133849014443 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1133849014444 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1133849014445 classical (c) SDRs; Region: SDR_c; cd05233 1133849014446 NAD(P) binding site [chemical binding]; other site 1133849014447 active site 1133849014448 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 1133849014449 lycopene cyclase; Region: lycopene_cycl; TIGR01789 1133849014450 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1133849014451 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1133849014452 putative DNA binding site [nucleotide binding]; other site 1133849014453 putative homodimer interface [polypeptide binding]; other site 1133849014454 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1133849014455 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1133849014456 Coenzyme A binding pocket [chemical binding]; other site 1133849014457 Golgi complex component 7 (COG7); Region: COG7; pfam10191 1133849014458 oxidase reductase; Provisional; Region: PTZ00273 1133849014459 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1133849014460 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1133849014461 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1133849014462 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1133849014463 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 1133849014464 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1133849014465 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1133849014466 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1133849014467 Walker A/P-loop; other site 1133849014468 ATP binding site [chemical binding]; other site 1133849014469 Q-loop/lid; other site 1133849014470 ABC transporter signature motif; other site 1133849014471 Walker B; other site 1133849014472 D-loop; other site 1133849014473 H-loop/switch region; other site 1133849014474 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1133849014475 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 1133849014476 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1133849014477 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1133849014478 EspG family; Region: ESX-1_EspG; pfam14011 1133849014479 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1133849014480 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1133849014481 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1133849014482 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1133849014483 putative hydrophobic ligand binding site [chemical binding]; other site 1133849014484 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849014485 putative DNA binding site [nucleotide binding]; other site 1133849014486 putative Zn2+ binding site [ion binding]; other site 1133849014487 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1133849014488 TIGR03086 family protein; Region: TIGR03086 1133849014489 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1133849014490 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1133849014491 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1133849014492 trimerization site [polypeptide binding]; other site 1133849014493 active site 1133849014494 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1133849014495 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1133849014496 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849014497 catalytic residue [active] 1133849014498 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1133849014499 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1133849014500 Walker A/P-loop; other site 1133849014501 ATP binding site [chemical binding]; other site 1133849014502 Q-loop/lid; other site 1133849014503 ABC transporter signature motif; other site 1133849014504 Walker B; other site 1133849014505 D-loop; other site 1133849014506 H-loop/switch region; other site 1133849014507 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1133849014508 FeS assembly protein SufD; Region: sufD; TIGR01981 1133849014509 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1133849014510 FeS assembly protein SufB; Region: sufB; TIGR01980 1133849014511 Predicted transcriptional regulator [Transcription]; Region: COG2345 1133849014512 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849014513 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849014514 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1133849014515 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1133849014516 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1133849014517 Walker A/P-loop; other site 1133849014518 ATP binding site [chemical binding]; other site 1133849014519 Q-loop/lid; other site 1133849014520 ABC transporter signature motif; other site 1133849014521 Walker B; other site 1133849014522 D-loop; other site 1133849014523 H-loop/switch region; other site 1133849014524 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1133849014525 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1133849014526 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1133849014527 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1133849014528 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1133849014529 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1133849014530 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849014531 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849014532 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849014533 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849014534 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1133849014535 mce related protein; Region: MCE; pfam02470 1133849014536 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1133849014537 mce related protein; Region: MCE; pfam02470 1133849014538 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1133849014539 mce related protein; Region: MCE; pfam02470 1133849014540 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1133849014541 mce related protein; Region: MCE; pfam02470 1133849014542 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1133849014543 mce related protein; Region: MCE; pfam02470 1133849014544 mce related protein; Region: MCE; pfam02470 1133849014545 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1133849014546 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1133849014547 Permease; Region: Permease; pfam02405 1133849014548 Permease; Region: Permease; pfam02405 1133849014549 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 1133849014550 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1133849014551 putative ligand binding site [chemical binding]; other site 1133849014552 putative NAD binding site [chemical binding]; other site 1133849014553 catalytic site [active] 1133849014554 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849014555 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849014556 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1133849014557 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1133849014558 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1133849014559 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1133849014560 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1133849014561 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1133849014562 substrate binding pocket [chemical binding]; other site 1133849014563 membrane-bound complex binding site; other site 1133849014564 hinge residues; other site 1133849014565 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1133849014566 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1133849014567 NADP binding site [chemical binding]; other site 1133849014568 dimer interface [polypeptide binding]; other site 1133849014569 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849014570 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849014571 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1133849014572 hypothetical protein; Provisional; Region: PRK06184 1133849014573 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1133849014574 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1133849014575 UbiA prenyltransferase family; Region: UbiA; pfam01040 1133849014576 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1133849014577 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1133849014578 TPP-binding site [chemical binding]; other site 1133849014579 dimer interface [polypeptide binding]; other site 1133849014580 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1133849014581 PYR/PP interface [polypeptide binding]; other site 1133849014582 dimer interface [polypeptide binding]; other site 1133849014583 TPP binding site [chemical binding]; other site 1133849014584 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1133849014585 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1133849014586 putative active site [active] 1133849014587 transaldolase; Provisional; Region: PRK03903 1133849014588 catalytic residue [active] 1133849014589 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1133849014590 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1133849014591 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1133849014592 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1133849014593 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 1133849014594 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1133849014595 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1133849014596 putative active site [active] 1133849014597 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1133849014598 TPP-binding site [chemical binding]; other site 1133849014599 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1133849014600 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1133849014601 PYR/PP interface [polypeptide binding]; other site 1133849014602 dimer interface [polypeptide binding]; other site 1133849014603 TPP binding site [chemical binding]; other site 1133849014604 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1133849014605 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1133849014606 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849014607 Cytochrome P450; Region: p450; cl12078 1133849014608 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849014609 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1133849014610 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1133849014611 G2 box; other site 1133849014612 Switch I region; other site 1133849014613 G3 box; other site 1133849014614 Switch II region; other site 1133849014615 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1133849014616 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 1133849014617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849014618 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1133849014619 ATP binding site [chemical binding]; other site 1133849014620 Mg2+ binding site [ion binding]; other site 1133849014621 G-X-G motif; other site 1133849014622 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1133849014623 hydrophobic ligand binding site; other site 1133849014624 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1133849014625 short chain dehydrogenase; Provisional; Region: PRK08303 1133849014626 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849014627 NAD(P) binding site [chemical binding]; other site 1133849014628 active site 1133849014629 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1133849014630 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1133849014631 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1133849014632 dimerization interface [polypeptide binding]; other site 1133849014633 substrate binding pocket [chemical binding]; other site 1133849014634 Transmembrane secretion effector; Region: MFS_3; pfam05977 1133849014635 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849014636 putative substrate translocation pore; other site 1133849014637 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849014638 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849014639 Secretory lipase; Region: LIP; pfam03583 1133849014640 META domain; Region: META; pfam03724 1133849014641 META domain; Region: META; pfam03724 1133849014642 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1133849014643 triosephosphate isomerase; Provisional; Region: PRK14565 1133849014644 substrate binding site [chemical binding]; other site 1133849014645 dimer interface [polypeptide binding]; other site 1133849014646 catalytic triad [active] 1133849014647 Phosphoglycerate kinase; Region: PGK; pfam00162 1133849014648 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1133849014649 substrate binding site [chemical binding]; other site 1133849014650 hinge regions; other site 1133849014651 ADP binding site [chemical binding]; other site 1133849014652 catalytic site [active] 1133849014653 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1133849014654 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1133849014655 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1133849014656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1133849014657 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1133849014658 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1133849014659 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1133849014660 phosphate binding site [ion binding]; other site 1133849014661 putative substrate binding pocket [chemical binding]; other site 1133849014662 dimer interface [polypeptide binding]; other site 1133849014663 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1133849014664 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1133849014665 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1133849014666 GIY-YIG motif/motif A; other site 1133849014667 active site 1133849014668 catalytic site [active] 1133849014669 putative DNA binding site [nucleotide binding]; other site 1133849014670 metal binding site [ion binding]; metal-binding site 1133849014671 UvrB/uvrC motif; Region: UVR; pfam02151 1133849014672 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1133849014673 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1133849014674 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1133849014675 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1133849014676 motif II; other site 1133849014677 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1133849014678 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1133849014679 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1133849014680 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1133849014681 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1133849014682 homopentamer interface [polypeptide binding]; other site 1133849014683 active site 1133849014684 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1133849014685 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1133849014686 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1133849014687 dimerization interface [polypeptide binding]; other site 1133849014688 active site 1133849014689 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1133849014690 Lumazine binding domain; Region: Lum_binding; pfam00677 1133849014691 Lumazine binding domain; Region: Lum_binding; pfam00677 1133849014692 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1133849014693 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1133849014694 substrate binding site [chemical binding]; other site 1133849014695 hexamer interface [polypeptide binding]; other site 1133849014696 metal binding site [ion binding]; metal-binding site 1133849014697 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1133849014698 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 1133849014699 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849014700 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1133849014701 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1133849014702 DNA binding residues [nucleotide binding] 1133849014703 Protein of unknown function (DUF419); Region: DUF419; cl15265 1133849014704 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1133849014705 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1133849014706 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1133849014707 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1133849014708 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1133849014709 putative active site [active] 1133849014710 substrate binding site [chemical binding]; other site 1133849014711 putative cosubstrate binding site; other site 1133849014712 catalytic site [active] 1133849014713 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1133849014714 substrate binding site [chemical binding]; other site 1133849014715 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1133849014716 active site 1133849014717 catalytic residues [active] 1133849014718 metal binding site [ion binding]; metal-binding site 1133849014719 Lipase (class 2); Region: Lipase_2; pfam01674 1133849014720 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849014721 Predicted transcriptional regulators [Transcription]; Region: COG1695 1133849014722 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1133849014723 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849014724 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849014725 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1133849014726 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849014727 NAD(P) binding site [chemical binding]; other site 1133849014728 active site 1133849014729 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849014730 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849014731 Subtilisin inhibitor-like; Region: SSI; cl11594 1133849014732 primosome assembly protein PriA; Provisional; Region: PRK14873 1133849014733 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1133849014734 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1133849014735 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1133849014736 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1133849014737 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1133849014738 Flavoprotein; Region: Flavoprotein; pfam02441 1133849014739 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1133849014740 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 1133849014741 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1133849014742 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1133849014743 catalytic site [active] 1133849014744 G-X2-G-X-G-K; other site 1133849014745 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1133849014746 active site 1133849014747 dimer interface [polypeptide binding]; other site 1133849014748 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1133849014749 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1133849014750 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1133849014751 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1133849014752 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1133849014753 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1133849014754 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1133849014755 IMP binding site; other site 1133849014756 dimer interface [polypeptide binding]; other site 1133849014757 interdomain contacts; other site 1133849014758 partial ornithine binding site; other site 1133849014759 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1133849014760 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1133849014761 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1133849014762 catalytic site [active] 1133849014763 subunit interface [polypeptide binding]; other site 1133849014764 dihydroorotase; Validated; Region: pyrC; PRK09357 1133849014765 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1133849014766 active site 1133849014767 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1133849014768 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1133849014769 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1133849014770 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1133849014771 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 1133849014772 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849014773 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 1133849014774 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 1133849014775 Predicted transcriptional regulators [Transcription]; Region: COG1695 1133849014776 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1133849014777 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1133849014778 HD domain; Region: HD_4; pfam13328 1133849014779 CAAX protease self-immunity; Region: Abi; pfam02517 1133849014780 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849014781 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849014782 Possible enoyl reductase; Region: MDR_enoyl_red; cd08244 1133849014783 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1133849014784 putative NAD(P) binding site [chemical binding]; other site 1133849014785 hypothetical protein; Provisional; Region: PRK06185 1133849014786 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1133849014787 GXWXG protein; Region: GXWXG; pfam14231 1133849014788 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 1133849014789 TIR domain; Region: TIR_2; pfam13676 1133849014790 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1133849014791 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 1133849014792 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1133849014793 NACHT domain; Region: NACHT; pfam05729 1133849014794 Walker A motif; other site 1133849014795 ATP binding site [chemical binding]; other site 1133849014796 Walker B motif; other site 1133849014797 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1133849014798 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1133849014799 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1133849014800 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1133849014801 structural tetrad; other site 1133849014802 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1133849014803 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1133849014804 structural tetrad; other site 1133849014805 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1133849014806 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1133849014807 transmembrane helices; other site 1133849014808 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1133849014809 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1133849014810 active site 1133849014811 YCII-related domain; Region: YCII; cl00999 1133849014812 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1133849014813 putative RNA binding site [nucleotide binding]; other site 1133849014814 elongation factor P; Validated; Region: PRK00529 1133849014815 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1133849014816 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1133849014817 RNA binding site [nucleotide binding]; other site 1133849014818 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1133849014819 RNA binding site [nucleotide binding]; other site 1133849014820 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1133849014821 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1133849014822 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1133849014823 active site 1133849014824 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1133849014825 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1133849014826 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cl00323 1133849014827 Tetramer interface [polypeptide binding]; other site 1133849014828 active site 1133849014829 FMN-binding site [chemical binding]; other site 1133849014830 shikimate kinase; Reviewed; Region: aroK; PRK00131 1133849014831 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1133849014832 ADP binding site [chemical binding]; other site 1133849014833 magnesium binding site [ion binding]; other site 1133849014834 putative shikimate binding site; other site 1133849014835 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1133849014836 active site 1133849014837 dimer interface [polypeptide binding]; other site 1133849014838 metal binding site [ion binding]; metal-binding site 1133849014839 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849014840 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1133849014841 NAD(P) binding site [chemical binding]; other site 1133849014842 active site 1133849014843 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849014844 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849014845 WHG domain; Region: WHG; pfam13305 1133849014846 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1133849014847 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1133849014848 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1133849014849 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1133849014850 YCII-related domain; Region: YCII; cl00999 1133849014851 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1133849014852 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1133849014853 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1133849014854 NAD(P) binding site [chemical binding]; other site 1133849014855 shikimate binding site; other site 1133849014856 YceG-like family; Region: YceG; pfam02618 1133849014857 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 1133849014858 dimerization interface [polypeptide binding]; other site 1133849014859 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1133849014860 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1133849014861 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1133849014862 motif 1; other site 1133849014863 active site 1133849014864 motif 2; other site 1133849014865 motif 3; other site 1133849014866 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1133849014867 DHHA1 domain; Region: DHHA1; pfam02272 1133849014868 recombination factor protein RarA; Reviewed; Region: PRK13342 1133849014869 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1133849014870 Walker A motif; other site 1133849014871 ATP binding site [chemical binding]; other site 1133849014872 Walker B motif; other site 1133849014873 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1133849014874 PhoD-like phosphatase; Region: PhoD; pfam09423 1133849014875 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1133849014876 putative active site [active] 1133849014877 putative metal binding site [ion binding]; other site 1133849014878 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1133849014879 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1133849014880 substrate binding site [chemical binding]; other site 1133849014881 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 1133849014882 Domain of unknown function (DUF389); Region: DUF389; cl00781 1133849014883 Domain of unknown function (DUF389); Region: DUF389; cl00781 1133849014884 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1133849014885 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1133849014886 dimer interface [polypeptide binding]; other site 1133849014887 anticodon binding site; other site 1133849014888 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1133849014889 homodimer interface [polypeptide binding]; other site 1133849014890 motif 1; other site 1133849014891 active site 1133849014892 motif 2; other site 1133849014893 GAD domain; Region: GAD; pfam02938 1133849014894 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1133849014895 active site 1133849014896 motif 3; other site 1133849014897 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1133849014898 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1133849014899 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1133849014900 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 1133849014901 putative NADP binding site [chemical binding]; other site 1133849014902 putative substrate binding site [chemical binding]; other site 1133849014903 active site 1133849014904 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1133849014905 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1133849014906 FeS/SAM binding site; other site 1133849014907 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1133849014908 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1133849014909 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1133849014910 dimer interface [polypeptide binding]; other site 1133849014911 PYR/PP interface [polypeptide binding]; other site 1133849014912 TPP binding site [chemical binding]; other site 1133849014913 substrate binding site [chemical binding]; other site 1133849014914 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1133849014915 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1133849014916 TPP-binding site [chemical binding]; other site 1133849014917 malate dehydrogenase; Provisional; Region: PRK05442 1133849014918 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1133849014919 NAD(P) binding site [chemical binding]; other site 1133849014920 dimer interface [polypeptide binding]; other site 1133849014921 malate binding site [chemical binding]; other site 1133849014922 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1133849014923 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1133849014924 dimer interface [polypeptide binding]; other site 1133849014925 motif 1; other site 1133849014926 active site 1133849014927 motif 2; other site 1133849014928 motif 3; other site 1133849014929 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1133849014930 anticodon binding site; other site 1133849014931 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1133849014932 active site 1133849014933 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1133849014934 Walker A motif; other site 1133849014935 ATP binding site [chemical binding]; other site 1133849014936 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 1133849014937 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 1133849014938 Walker B motif; other site 1133849014939 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1133849014940 Peptidase family M23; Region: Peptidase_M23; pfam01551 1133849014941 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1133849014942 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1133849014943 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1133849014944 catalytic residue [active] 1133849014945 NlpC/P60 family; Region: NLPC_P60; cl17555 1133849014946 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1133849014947 AAA-like domain; Region: AAA_10; pfam12846 1133849014948 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 1133849014949 Cutinase; Region: Cutinase; pfam01083 1133849014950 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 1133849014951 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1133849014952 Zn2+ binding site [ion binding]; other site 1133849014953 Mg2+ binding site [ion binding]; other site 1133849014954 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1133849014955 synthetase active site [active] 1133849014956 NTP binding site [chemical binding]; other site 1133849014957 metal binding site [ion binding]; metal-binding site 1133849014958 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1133849014959 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1133849014960 Uncharacterized conserved protein [Function unknown]; Region: COG3379 1133849014961 Sulfatase; Region: Sulfatase; cl17466 1133849014962 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1133849014963 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1133849014964 active site 1133849014965 metal binding site [ion binding]; metal-binding site 1133849014966 Adenylosuccinate synthetase; Region: Adenylsucc_synt; pfam00709 1133849014967 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1133849014968 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1133849014969 homotrimer interaction site [polypeptide binding]; other site 1133849014970 putative active site [active] 1133849014971 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849014972 NAD(P) binding site [chemical binding]; other site 1133849014973 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1133849014974 putative deacylase active site [active] 1133849014975 Predicted transcriptional regulators [Transcription]; Region: COG1733 1133849014976 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1133849014977 Protein of unknown function (DUF419); Region: DUF419; pfam04237 1133849014978 Predicted transcriptional regulator [Transcription]; Region: COG1959 1133849014979 Transcriptional regulator; Region: Rrf2; pfam02082 1133849014980 SnoaL-like domain; Region: SnoaL_3; pfam13474 1133849014981 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1133849014982 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849014983 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1133849014984 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1133849014985 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849014986 Walker A/P-loop; other site 1133849014987 ATP binding site [chemical binding]; other site 1133849014988 Q-loop/lid; other site 1133849014989 ABC transporter signature motif; other site 1133849014990 Walker B; other site 1133849014991 D-loop; other site 1133849014992 H-loop/switch region; other site 1133849014993 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1133849014994 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 1133849014995 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 1133849014996 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1133849014997 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1133849014998 putative di-iron ligands [ion binding]; other site 1133849014999 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 1133849015000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849015001 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1133849015002 putative substrate translocation pore; other site 1133849015003 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849015004 CGNR zinc finger; Region: zf-CGNR; pfam11706 1133849015005 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1133849015006 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849015007 S-adenosylmethionine binding site [chemical binding]; other site 1133849015008 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1133849015009 active site 1133849015010 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1133849015011 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1133849015012 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1133849015013 Protein export membrane protein; Region: SecD_SecF; pfam02355 1133849015014 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1133849015015 Protein export membrane protein; Region: SecD_SecF; cl14618 1133849015016 Preprotein translocase subunit; Region: YajC; pfam02699 1133849015017 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1133849015018 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1133849015019 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849015020 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849015021 DivIVA domain; Region: DivI1A_domain; TIGR03544 1133849015022 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 1133849015023 DivIVA domain; Region: DivI1A_domain; TIGR03544 1133849015024 DivIVA domain; Region: DivI1A_domain; TIGR03544 1133849015025 DivIVA domain; Region: DivI1A_domain; TIGR03544 1133849015026 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1133849015027 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1133849015028 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 1133849015029 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849015030 S-adenosylmethionine binding site [chemical binding]; other site 1133849015031 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1133849015032 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1133849015033 Walker A motif; other site 1133849015034 ATP binding site [chemical binding]; other site 1133849015035 Walker B motif; other site 1133849015036 arginine finger; other site 1133849015037 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1133849015038 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1133849015039 RuvA N terminal domain; Region: RuvA_N; pfam01330 1133849015040 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1133849015041 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1133849015042 active site 1133849015043 putative DNA-binding cleft [nucleotide binding]; other site 1133849015044 dimer interface [polypeptide binding]; other site 1133849015045 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1133849015046 active site 1133849015047 Predicted esterase [General function prediction only]; Region: COG0627 1133849015048 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1133849015049 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1133849015050 conserved cys residue [active] 1133849015051 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849015052 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849015053 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849015054 putative DNA binding site [nucleotide binding]; other site 1133849015055 putative Zn2+ binding site [ion binding]; other site 1133849015056 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 1133849015057 putative hydrophobic ligand binding site [chemical binding]; other site 1133849015058 hypothetical protein; Validated; Region: PRK00110 1133849015059 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1133849015060 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118 1133849015061 predicted active site [active] 1133849015062 catalytic triad [active] 1133849015063 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1133849015064 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1133849015065 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1133849015066 active site 1133849015067 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1133849015068 catalytic triad [active] 1133849015069 dimer interface [polypeptide binding]; other site 1133849015070 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1133849015071 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1133849015072 nucleotide binding site/active site [active] 1133849015073 HIT family signature motif; other site 1133849015074 catalytic residue [active] 1133849015075 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1133849015076 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1133849015077 active site 1133849015078 multimer interface [polypeptide binding]; other site 1133849015079 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 1133849015080 nudix motif; other site 1133849015081 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1133849015082 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1133849015083 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1133849015084 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1133849015085 putative acyl-acceptor binding pocket; other site 1133849015086 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1133849015087 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1133849015088 nucleotide binding site/active site [active] 1133849015089 HIT family signature motif; other site 1133849015090 catalytic residue [active] 1133849015091 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1133849015092 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1133849015093 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1133849015094 active site 1133849015095 dimer interface [polypeptide binding]; other site 1133849015096 motif 1; other site 1133849015097 motif 2; other site 1133849015098 motif 3; other site 1133849015099 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1133849015100 anticodon binding site; other site 1133849015101 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1133849015102 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 1133849015103 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1133849015104 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1133849015105 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1133849015106 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1133849015107 active site clefts [active] 1133849015108 zinc binding site [ion binding]; other site 1133849015109 dimer interface [polypeptide binding]; other site 1133849015110 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1133849015111 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1133849015112 active site clefts [active] 1133849015113 Carbonic anhydrase; Region: Pro_CA; smart00947 1133849015114 zinc binding site [ion binding]; other site 1133849015115 dimer interface [polypeptide binding]; other site 1133849015116 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1133849015117 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1133849015118 Walker A motif; other site 1133849015119 ATP binding site [chemical binding]; other site 1133849015120 Walker B motif; other site 1133849015121 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 1133849015122 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 1133849015123 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 1133849015124 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 1133849015125 YcaO-like family; Region: YcaO; pfam02624 1133849015126 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1133849015127 NADPH bind site [chemical binding]; other site 1133849015128 putative FMN binding site [chemical binding]; other site 1133849015129 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1133849015130 dimer interface [polypeptide binding]; other site 1133849015131 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 1133849015132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849015133 putative substrate translocation pore; other site 1133849015134 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1133849015135 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1133849015136 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1133849015137 trimer interface [polypeptide binding]; other site 1133849015138 putative metal binding site [ion binding]; other site 1133849015139 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1133849015140 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1133849015141 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1133849015142 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1133849015143 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1133849015144 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1133849015145 MMPL family; Region: MMPL; pfam03176 1133849015146 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1133849015147 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1133849015148 substrate binding site [chemical binding]; other site 1133849015149 oxyanion hole (OAH) forming residues; other site 1133849015150 trimer interface [polypeptide binding]; other site 1133849015151 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1133849015152 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1133849015153 active site 2 [active] 1133849015154 active site 1 [active] 1133849015155 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1133849015156 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1133849015157 active site 1133849015158 Thioesterase; Region: PKS_TE; smart00824 1133849015159 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1133849015160 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1133849015161 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1133849015162 active site 1133849015163 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1133849015164 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1133849015165 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1133849015166 putative NADP binding site [chemical binding]; other site 1133849015167 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1133849015168 active site 1133849015169 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1133849015170 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1133849015171 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1133849015172 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 1133849015173 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1133849015174 active site 1133849015175 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1133849015176 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849015177 S-adenosylmethionine binding site [chemical binding]; other site 1133849015178 short chain dehydrogenase; Provisional; Region: PRK08303 1133849015179 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849015180 NAD(P) binding site [chemical binding]; other site 1133849015181 active site 1133849015182 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849015183 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1133849015184 NAD(P) binding site [chemical binding]; other site 1133849015185 active site 1133849015186 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1133849015187 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849015188 acyl-activating enzyme (AAE) consensus motif; other site 1133849015189 AMP binding site [chemical binding]; other site 1133849015190 active site 1133849015191 CoA binding site [chemical binding]; other site 1133849015192 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1133849015193 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1133849015194 Di-iron ligands [ion binding]; other site 1133849015195 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1133849015196 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1133849015197 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1133849015198 ParB-like nuclease domain; Region: ParB; smart00470 1133849015199 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1133849015200 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1133849015201 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1133849015202 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849015203 dimer interface [polypeptide binding]; other site 1133849015204 conserved gate region; other site 1133849015205 putative PBP binding loops; other site 1133849015206 ABC-ATPase subunit interface; other site 1133849015207 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1133849015208 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849015209 dimer interface [polypeptide binding]; other site 1133849015210 conserved gate region; other site 1133849015211 putative PBP binding loops; other site 1133849015212 ABC-ATPase subunit interface; other site 1133849015213 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1133849015214 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1133849015215 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 1133849015216 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1133849015217 substrate binding site [chemical binding]; other site 1133849015218 Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648 1133849015219 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1133849015220 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1133849015221 Predicted acyl esterases [General function prediction only]; Region: COG2936 1133849015222 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1133849015223 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1133849015224 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1133849015225 NAD(P) binding site [chemical binding]; other site 1133849015226 catalytic residues [active] 1133849015227 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1133849015228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849015229 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1133849015230 putative substrate translocation pore; other site 1133849015231 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1133849015232 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1133849015233 NAD(P) binding site [chemical binding]; other site 1133849015234 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1133849015235 substrate binding site [chemical binding]; other site 1133849015236 THF binding site; other site 1133849015237 zinc-binding site [ion binding]; other site 1133849015238 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 1133849015239 cell division protein ZipA; Provisional; Region: PRK03427 1133849015240 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1133849015241 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1133849015242 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 1133849015243 putative substrate binding pocket [chemical binding]; other site 1133849015244 putative dimerization interface [polypeptide binding]; other site 1133849015245 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1133849015246 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1133849015247 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849015248 Cytochrome P450; Region: p450; cl12078 1133849015249 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1133849015250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849015251 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1133849015252 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1133849015253 Coenzyme A binding pocket [chemical binding]; other site 1133849015254 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1133849015255 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849015256 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1133849015257 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1133849015258 Walker A/P-loop; other site 1133849015259 ATP binding site [chemical binding]; other site 1133849015260 Q-loop/lid; other site 1133849015261 ABC transporter signature motif; other site 1133849015262 Walker B; other site 1133849015263 D-loop; other site 1133849015264 H-loop/switch region; other site 1133849015265 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1133849015266 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1133849015267 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1133849015268 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1133849015269 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 1133849015270 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1133849015271 Walker A motif; other site 1133849015272 ATP binding site [chemical binding]; other site 1133849015273 Walker B motif; other site 1133849015274 hypothetical protein; Provisional; Region: PRK14059 1133849015275 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1133849015276 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849015277 TAP-like protein; Region: Abhydrolase_4; pfam08386 1133849015278 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1133849015279 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1133849015280 SelR domain; Region: SelR; pfam01641 1133849015281 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1133849015282 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1133849015283 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849015284 NAD(P) binding site [chemical binding]; other site 1133849015285 active site 1133849015286 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 1133849015287 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1133849015288 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849015289 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1133849015290 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 1133849015291 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1133849015292 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1133849015293 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1133849015294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849015295 Mg2+ binding site [ion binding]; other site 1133849015296 G-X-G motif; other site 1133849015297 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1133849015298 anchoring element; other site 1133849015299 dimer interface [polypeptide binding]; other site 1133849015300 ATP binding site [chemical binding]; other site 1133849015301 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1133849015302 active site 1133849015303 putative metal-binding site [ion binding]; other site 1133849015304 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1133849015305 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1133849015306 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1133849015307 substrate binding site [chemical binding]; other site 1133849015308 active site 1133849015309 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1133849015310 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1133849015311 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1133849015312 catalytic site [active] 1133849015313 putative active site [active] 1133849015314 putative substrate binding site [chemical binding]; other site 1133849015315 HRDC domain; Region: HRDC; pfam00570 1133849015316 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1133849015317 putative hydrophobic ligand binding site [chemical binding]; other site 1133849015318 protein interface [polypeptide binding]; other site 1133849015319 gate; other site 1133849015320 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 1133849015321 CGNR zinc finger; Region: zf-CGNR; pfam11706 1133849015322 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1133849015323 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1133849015324 TPP-binding site; other site 1133849015325 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1133849015326 PYR/PP interface [polypeptide binding]; other site 1133849015327 dimer interface [polypeptide binding]; other site 1133849015328 TPP binding site [chemical binding]; other site 1133849015329 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1133849015330 glutaminase A; Region: Gln_ase; TIGR03814 1133849015331 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1133849015332 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1133849015333 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1133849015334 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1133849015335 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1133849015336 ligand binding site [chemical binding]; other site 1133849015337 flexible hinge region; other site 1133849015338 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1133849015339 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 1133849015340 CAAX protease self-immunity; Region: Abi; pfam02517 1133849015341 enoyl-CoA hydratase; Provisional; Region: PRK05864 1133849015342 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1133849015343 substrate binding site [chemical binding]; other site 1133849015344 oxyanion hole (OAH) forming residues; other site 1133849015345 trimer interface [polypeptide binding]; other site 1133849015346 MarR family; Region: MarR_2; pfam12802 1133849015347 SnoaL-like domain; Region: SnoaL_4; pfam13577 1133849015348 TRAM domain; Region: TRAM; pfam01938 1133849015349 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1133849015350 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1133849015351 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1133849015352 TrkA-N domain; Region: TrkA_N; pfam02254 1133849015353 TrkA-C domain; Region: TrkA_C; pfam02080 1133849015354 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1133849015355 TrkA-N domain; Region: TrkA_N; pfam02254 1133849015356 TrkA-C domain; Region: TrkA_C; pfam02080 1133849015357 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1133849015358 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849015359 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1133849015360 DNA binding residues [nucleotide binding] 1133849015361 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1133849015362 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1133849015363 generic binding surface I; other site 1133849015364 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1133849015365 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1133849015366 trimer interface [polypeptide binding]; other site 1133849015367 active site 1133849015368 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1133849015369 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1133849015370 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1133849015371 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1133849015372 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1133849015373 active site 1133849015374 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1133849015375 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1133849015376 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1133849015377 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849015378 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1133849015379 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1133849015380 DNA binding residues [nucleotide binding] 1133849015381 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1133849015382 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1133849015383 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1133849015384 dimerization interface [polypeptide binding]; other site 1133849015385 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1133849015386 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1133849015387 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1133849015388 Fic/DOC family; Region: Fic; cl00960 1133849015389 Rhomboid family; Region: Rhomboid; cl11446 1133849015390 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1133849015391 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1133849015392 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1133849015393 TrkA-C domain; Region: TrkA_C; pfam02080 1133849015394 Histidine kinase; Region: HisKA_3; pfam07730 1133849015395 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1133849015396 ATP binding site [chemical binding]; other site 1133849015397 Mg2+ binding site [ion binding]; other site 1133849015398 G-X-G motif; other site 1133849015399 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849015400 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849015401 active site 1133849015402 phosphorylation site [posttranslational modification] 1133849015403 intermolecular recognition site; other site 1133849015404 dimerization interface [polypeptide binding]; other site 1133849015405 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849015406 DNA binding residues [nucleotide binding] 1133849015407 dimerization interface [polypeptide binding]; other site 1133849015408 Protein of unknown function (DUF952); Region: DUF952; pfam06108 1133849015409 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849015410 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1133849015411 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1133849015412 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1133849015413 ATP binding site [chemical binding]; other site 1133849015414 putative Mg++ binding site [ion binding]; other site 1133849015415 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1133849015416 nucleotide binding region [chemical binding]; other site 1133849015417 ATP-binding site [chemical binding]; other site 1133849015418 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849015419 S-adenosylmethionine binding site [chemical binding]; other site 1133849015420 Cupin domain; Region: Cupin_2; cl17218 1133849015421 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1133849015422 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849015423 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1133849015424 NAD(P) binding site [chemical binding]; other site 1133849015425 active site 1133849015426 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849015427 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849015428 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1133849015429 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1133849015430 ATP binding site [chemical binding]; other site 1133849015431 putative Mg++ binding site [ion binding]; other site 1133849015432 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1133849015433 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1133849015434 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1133849015435 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1133849015436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849015437 putative substrate translocation pore; other site 1133849015438 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1133849015439 active site 1133849015440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849015441 S-adenosylmethionine binding site [chemical binding]; other site 1133849015442 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1133849015443 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1133849015444 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849015445 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1133849015446 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1133849015447 DNA binding residues [nucleotide binding] 1133849015448 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849015449 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849015450 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1133849015451 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1133849015452 Coenzyme A binding pocket [chemical binding]; other site 1133849015453 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1133849015454 CoA binding domain; Region: CoA_binding_2; pfam13380 1133849015455 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1133849015456 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1133849015457 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1133849015458 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1133849015459 active site 1133849015460 Zn binding site [ion binding]; other site 1133849015461 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1133849015462 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1133849015463 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1133849015464 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1133849015465 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1133849015466 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1133849015467 NAD binding site [chemical binding]; other site 1133849015468 homodimer interface [polypeptide binding]; other site 1133849015469 active site 1133849015470 substrate binding site [chemical binding]; other site 1133849015471 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1133849015472 PAC2 family; Region: PAC2; pfam09754 1133849015473 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1133849015474 ATP binding site [chemical binding]; other site 1133849015475 putative Mg++ binding site [ion binding]; other site 1133849015476 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1133849015477 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1133849015478 nucleotide binding region [chemical binding]; other site 1133849015479 ATP-binding site [chemical binding]; other site 1133849015480 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 1133849015481 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1133849015482 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 1133849015483 dimer interface [polypeptide binding]; other site 1133849015484 active site 1133849015485 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1133849015486 catalytic residues [active] 1133849015487 substrate binding site [chemical binding]; other site 1133849015488 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 1133849015489 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849015490 S-adenosylmethionine binding site [chemical binding]; other site 1133849015491 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 1133849015492 active site 1 [active] 1133849015493 dimer interface [polypeptide binding]; other site 1133849015494 hexamer interface [polypeptide binding]; other site 1133849015495 active site 2 [active] 1133849015496 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1133849015497 classical (c) SDRs; Region: SDR_c; cd05233 1133849015498 NAD(P) binding site [chemical binding]; other site 1133849015499 active site 1133849015500 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849015501 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849015502 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1133849015503 putative active site pocket [active] 1133849015504 dimerization interface [polypeptide binding]; other site 1133849015505 putative catalytic residue [active] 1133849015506 C2 domain; Region: C2; cl14603 1133849015507 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1133849015508 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1133849015509 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1133849015510 dimerization interface [polypeptide binding]; other site 1133849015511 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1133849015512 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1133849015513 dimer interface [polypeptide binding]; other site 1133849015514 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1133849015515 catalytic triad [active] 1133849015516 peroxidatic and resolving cysteines [active] 1133849015517 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 1133849015518 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 1133849015519 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 1133849015520 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1133849015521 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 1133849015522 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849015523 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1133849015524 DNA binding residues [nucleotide binding] 1133849015525 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1133849015526 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1133849015527 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849015528 classical (c) SDRs; Region: SDR_c; cd05233 1133849015529 NAD(P) binding site [chemical binding]; other site 1133849015530 active site 1133849015531 acyl-CoA synthetase; Validated; Region: PRK07788 1133849015532 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849015533 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1133849015534 acyl-activating enzyme (AAE) consensus motif; other site 1133849015535 putative AMP binding site [chemical binding]; other site 1133849015536 putative active site [active] 1133849015537 putative CoA binding site [chemical binding]; other site 1133849015538 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1133849015539 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 1133849015540 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1133849015541 inhibitor-cofactor binding pocket; inhibition site 1133849015542 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849015543 catalytic residue [active] 1133849015544 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1133849015545 ATP binding site [chemical binding]; other site 1133849015546 putative Mg++ binding site [ion binding]; other site 1133849015547 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1133849015548 nucleotide binding region [chemical binding]; other site 1133849015549 ATP-binding site [chemical binding]; other site 1133849015550 Helicase associated domain (HA2); Region: HA2; pfam04408 1133849015551 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1133849015552 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1133849015553 transcriptional regulator NrdR; Region: TIGR00244 1133849015554 ATP cone domain; Region: ATP-cone; pfam03477 1133849015555 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1133849015556 LexA repressor; Validated; Region: PRK00215 1133849015557 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1133849015558 Catalytic site [active] 1133849015559 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1133849015560 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1133849015561 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1133849015562 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1133849015563 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849015564 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1133849015565 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1133849015566 hypothetical protein; Provisional; Region: PRK06834 1133849015567 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 1133849015568 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 1133849015569 active site 1133849015570 catalytic site [active] 1133849015571 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1133849015572 Glyco_18 domain; Region: Glyco_18; smart00636 1133849015573 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1133849015574 active site 1133849015575 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1133849015576 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1133849015577 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1133849015578 Secretory lipase; Region: LIP; pfam03583 1133849015579 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849015580 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849015581 Secretory lipase; Region: LIP; pfam03583 1133849015582 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 1133849015583 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 1133849015584 homodimer interface [polypeptide binding]; other site 1133849015585 putative substrate binding pocket [chemical binding]; other site 1133849015586 diiron center [ion binding]; other site 1133849015587 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849015588 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849015589 active site 1133849015590 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1133849015591 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1133849015592 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1133849015593 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1133849015594 putative acyl-acceptor binding pocket; other site 1133849015595 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1133849015596 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1133849015597 HflX GTPase family; Region: HflX; cd01878 1133849015598 G1 box; other site 1133849015599 GTP/Mg2+ binding site [chemical binding]; other site 1133849015600 Switch I region; other site 1133849015601 G2 box; other site 1133849015602 G3 box; other site 1133849015603 Switch II region; other site 1133849015604 G4 box; other site 1133849015605 G5 box; other site 1133849015606 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1133849015607 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1133849015608 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1133849015609 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1133849015610 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1133849015611 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1133849015612 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1133849015613 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 1133849015614 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1133849015615 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1133849015616 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1133849015617 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1133849015618 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1133849015619 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1133849015620 FeS/SAM binding site; other site 1133849015621 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1133849015622 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1133849015623 Walker A/P-loop; other site 1133849015624 ATP binding site [chemical binding]; other site 1133849015625 Q-loop/lid; other site 1133849015626 ABC transporter signature motif; other site 1133849015627 Walker B; other site 1133849015628 D-loop; other site 1133849015629 H-loop/switch region; other site 1133849015630 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1133849015631 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1133849015632 substrate binding pocket [chemical binding]; other site 1133849015633 membrane-bound complex binding site; other site 1133849015634 hinge residues; other site 1133849015635 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1133849015636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849015637 dimer interface [polypeptide binding]; other site 1133849015638 conserved gate region; other site 1133849015639 putative PBP binding loops; other site 1133849015640 ABC-ATPase subunit interface; other site 1133849015641 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1133849015642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849015643 dimer interface [polypeptide binding]; other site 1133849015644 conserved gate region; other site 1133849015645 putative PBP binding loops; other site 1133849015646 ABC-ATPase subunit interface; other site 1133849015647 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1133849015648 Peptidase family M28; Region: Peptidase_M28; pfam04389 1133849015649 metal binding site [ion binding]; metal-binding site 1133849015650 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1133849015651 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849015652 NAD(P) binding site [chemical binding]; other site 1133849015653 active site 1133849015654 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 1133849015655 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1133849015656 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1133849015657 DNA binding residues [nucleotide binding] 1133849015658 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1133849015659 recombinase A; Provisional; Region: recA; PRK09354 1133849015660 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1133849015661 hexamer interface [polypeptide binding]; other site 1133849015662 Walker A motif; other site 1133849015663 ATP binding site [chemical binding]; other site 1133849015664 Walker B motif; other site 1133849015665 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1133849015666 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1133849015667 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1133849015668 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1133849015669 AsnC family; Region: AsnC_trans_reg; pfam01037 1133849015670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849015671 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1133849015672 putative substrate translocation pore; other site 1133849015673 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 1133849015674 SnoaL-like domain; Region: SnoaL_2; pfam12680 1133849015675 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1133849015676 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1133849015677 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849015678 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 1133849015679 putative dimer interface [polypeptide binding]; other site 1133849015680 ligand binding site [chemical binding]; other site 1133849015681 Zn binding site [ion binding]; other site 1133849015682 CGNR zinc finger; Region: zf-CGNR; pfam11706 1133849015683 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1133849015684 TPR motif; other site 1133849015685 binding surface 1133849015686 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849015687 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849015688 Phosphotransferase enzyme family; Region: APH; pfam01636 1133849015689 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 1133849015690 active site 1133849015691 ATP binding site [chemical binding]; other site 1133849015692 antibiotic binding site [chemical binding]; other site 1133849015693 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1133849015694 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1133849015695 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1133849015696 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564 1133849015697 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1133849015698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849015699 putative substrate translocation pore; other site 1133849015700 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1133849015701 MarR family; Region: MarR; pfam01047 1133849015702 PRC-barrel domain; Region: PRC; pfam05239 1133849015703 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 1133849015704 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849015705 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849015706 active site 1133849015707 phosphorylation site [posttranslational modification] 1133849015708 intermolecular recognition site; other site 1133849015709 dimerization interface [polypeptide binding]; other site 1133849015710 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849015711 DNA binding residues [nucleotide binding] 1133849015712 dimerization interface [polypeptide binding]; other site 1133849015713 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1133849015714 DNA binding residues [nucleotide binding] 1133849015715 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1133849015716 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1133849015717 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849015718 non-specific DNA binding site [nucleotide binding]; other site 1133849015719 salt bridge; other site 1133849015720 sequence-specific DNA binding site [nucleotide binding]; other site 1133849015721 Competence-damaged protein; Region: CinA; pfam02464 1133849015722 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1133849015723 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1133849015724 Coenzyme A binding pocket [chemical binding]; other site 1133849015725 YCII-related domain; Region: YCII; cl00999 1133849015726 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1133849015727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1133849015728 Thioredoxin; Region: Thioredoxin_4; cl17273 1133849015729 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1133849015730 Helix-turn-helix domain; Region: HTH_18; pfam12833 1133849015731 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1133849015732 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1133849015733 structural tetrad; other site 1133849015734 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1133849015735 structural tetrad; other site 1133849015736 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1133849015737 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849015738 Protein of unknown function, DUF417; Region: DUF417; cl01162 1133849015739 CGNR zinc finger; Region: zf-CGNR; pfam11706 1133849015740 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1133849015741 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1133849015742 Walker A/P-loop; other site 1133849015743 ATP binding site [chemical binding]; other site 1133849015744 Q-loop/lid; other site 1133849015745 ABC transporter signature motif; other site 1133849015746 Walker B; other site 1133849015747 D-loop; other site 1133849015748 H-loop/switch region; other site 1133849015749 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1133849015750 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1133849015751 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1133849015752 TIGR03085 family protein; Region: TIGR03085 1133849015753 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1133849015754 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1133849015755 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1133849015756 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1133849015757 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1133849015758 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1133849015759 dimer interface [polypeptide binding]; other site 1133849015760 active site 1133849015761 catalytic residue [active] 1133849015762 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 1133849015763 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1133849015764 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1133849015765 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1133849015766 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849015767 ATP binding site [chemical binding]; other site 1133849015768 Mg2+ binding site [ion binding]; other site 1133849015769 G-X-G motif; other site 1133849015770 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849015771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849015772 active site 1133849015773 phosphorylation site [posttranslational modification] 1133849015774 intermolecular recognition site; other site 1133849015775 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849015776 DNA binding residues [nucleotide binding] 1133849015777 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1133849015778 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1133849015779 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1133849015780 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1133849015781 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849015782 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1133849015783 oligomeric interface; other site 1133849015784 putative active site [active] 1133849015785 homodimer interface [polypeptide binding]; other site 1133849015786 prevent-host-death family protein; Region: phd_fam; TIGR01552 1133849015787 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1133849015788 MarR family; Region: MarR_2; pfam12802 1133849015789 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1133849015790 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1133849015791 NAD(P) binding site [chemical binding]; other site 1133849015792 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1133849015793 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849015794 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849015795 active site 1133849015796 phosphorylation site [posttranslational modification] 1133849015797 intermolecular recognition site; other site 1133849015798 dimerization interface [polypeptide binding]; other site 1133849015799 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849015800 DNA binding residues [nucleotide binding] 1133849015801 dimerization interface [polypeptide binding]; other site 1133849015802 Histidine kinase; Region: HisKA_3; pfam07730 1133849015803 Cleavage and polyadenylation factor 2 C-terminal; Region: CPSF100_C; pfam13299 1133849015804 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1133849015805 ATP binding site [chemical binding]; other site 1133849015806 Mg2+ binding site [ion binding]; other site 1133849015807 G-X-G motif; other site 1133849015808 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1133849015809 active site 1133849015810 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1133849015811 active site 1133849015812 catalytic triad [active] 1133849015813 oxyanion hole [active] 1133849015814 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 1133849015815 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1133849015816 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1133849015817 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1133849015818 ABC1 family; Region: ABC1; cl17513 1133849015819 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849015820 Helix-turn-helix domain; Region: HTH_20; pfam12840 1133849015821 dimerization interface [polypeptide binding]; other site 1133849015822 putative DNA binding site [nucleotide binding]; other site 1133849015823 putative Zn2+ binding site [ion binding]; other site 1133849015824 helix_turn_helix, Arsenical Resistance Operon Repressor; Region: HTH_ARSR; smart00418 1133849015825 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1133849015826 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1133849015827 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1133849015828 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1133849015829 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1133849015830 oligomer interface [polypeptide binding]; other site 1133849015831 RNA binding site [nucleotide binding]; other site 1133849015832 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1133849015833 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1133849015834 RNase E interface [polypeptide binding]; other site 1133849015835 trimer interface [polypeptide binding]; other site 1133849015836 active site 1133849015837 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1133849015838 putative nucleic acid binding region [nucleotide binding]; other site 1133849015839 G-X-X-G motif; other site 1133849015840 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1133849015841 RNA binding site [nucleotide binding]; other site 1133849015842 domain interface; other site 1133849015843 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1133849015844 16S/18S rRNA binding site [nucleotide binding]; other site 1133849015845 S13e-L30e interaction site [polypeptide binding]; other site 1133849015846 25S rRNA binding site [nucleotide binding]; other site 1133849015847 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1133849015848 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1133849015849 active site 1133849015850 Riboflavin kinase; Region: Flavokinase; smart00904 1133849015851 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1133849015852 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849015853 putative DNA binding site [nucleotide binding]; other site 1133849015854 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1133849015855 FeoA domain; Region: FeoA; pfam04023 1133849015856 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1133849015857 tartrate dehydrogenase; Provisional; Region: PRK08194 1133849015858 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1133849015859 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1133849015860 tetramerization interface [polypeptide binding]; other site 1133849015861 NAD(P) binding site [chemical binding]; other site 1133849015862 catalytic residues [active] 1133849015863 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 1133849015864 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1133849015865 inhibitor-cofactor binding pocket; inhibition site 1133849015866 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849015867 catalytic residue [active] 1133849015868 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 1133849015869 putative amidase; Provisional; Region: PRK06169 1133849015870 Amidase; Region: Amidase; pfam01425 1133849015871 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 1133849015872 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1133849015873 NAD binding site [chemical binding]; other site 1133849015874 ligand binding site [chemical binding]; other site 1133849015875 catalytic site [active] 1133849015876 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1133849015877 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1133849015878 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1133849015879 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1133849015880 DNA-binding site [nucleotide binding]; DNA binding site 1133849015881 FCD domain; Region: FCD; pfam07729 1133849015882 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 1133849015883 EF-hand domain pair; Region: EF_hand_5; pfam13499 1133849015884 Ca2+ binding site [ion binding]; other site 1133849015885 EF-hand domain pair; Region: EF_hand_5; pfam13499 1133849015886 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 1133849015887 EF-hand domain pair; Region: EF_hand_5; pfam13499 1133849015888 Ca2+ binding site [ion binding]; other site 1133849015889 Domain of unknown function (DUF4345); Region: DUF4345; pfam14248 1133849015890 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849015891 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849015892 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1133849015893 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1133849015894 RNA binding site [nucleotide binding]; other site 1133849015895 active site 1133849015896 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1133849015897 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1133849015898 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1133849015899 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1133849015900 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1133849015901 active site 1133849015902 metal binding site [ion binding]; metal-binding site 1133849015903 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1133849015904 putative efflux protein, MATE family; Region: matE; TIGR00797 1133849015905 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1133849015906 DHH family; Region: DHH; pfam01368 1133849015907 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1133849015908 Protein of unknown function (DUF503); Region: DUF503; pfam04456 1133849015909 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1133849015910 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1133849015911 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1133849015912 G1 box; other site 1133849015913 putative GEF interaction site [polypeptide binding]; other site 1133849015914 GTP/Mg2+ binding site [chemical binding]; other site 1133849015915 Switch I region; other site 1133849015916 G2 box; other site 1133849015917 G3 box; other site 1133849015918 Switch II region; other site 1133849015919 G4 box; other site 1133849015920 G5 box; other site 1133849015921 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1133849015922 Translation-initiation factor 2; Region: IF-2; pfam11987 1133849015923 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1133849015924 Protein of unknown function (DUF448); Region: DUF448; pfam04296 1133849015925 putative RNA binding cleft [nucleotide binding]; other site 1133849015926 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1133849015927 NusA N-terminal domain; Region: NusA_N; pfam08529 1133849015928 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1133849015929 RNA binding site [nucleotide binding]; other site 1133849015930 homodimer interface [polypeptide binding]; other site 1133849015931 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1133849015932 G-X-X-G motif; other site 1133849015933 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1133849015934 G-X-X-G motif; other site 1133849015935 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1133849015936 Sm and related proteins; Region: Sm_like; cl00259 1133849015937 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1133849015938 putative oligomer interface [polypeptide binding]; other site 1133849015939 putative RNA binding site [nucleotide binding]; other site 1133849015940 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1133849015941 dinuclear metal binding motif [ion binding]; other site 1133849015942 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849015943 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849015944 active site 1133849015945 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1133849015946 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1133849015947 dimer interface [polypeptide binding]; other site 1133849015948 motif 1; other site 1133849015949 active site 1133849015950 motif 2; other site 1133849015951 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1133849015952 putative deacylase active site [active] 1133849015953 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1133849015954 active site 1133849015955 motif 3; other site 1133849015956 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1133849015957 anticodon binding site; other site 1133849015958 hypothetical protein; Validated; Region: PRK02101 1133849015959 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 1133849015960 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1133849015961 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1133849015962 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1133849015963 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1133849015964 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1133849015965 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1133849015966 tetrameric interface [polypeptide binding]; other site 1133849015967 NAD binding site [chemical binding]; other site 1133849015968 catalytic residues [active] 1133849015969 hypothetical protein; Provisional; Region: PRK06062 1133849015970 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1133849015971 inhibitor-cofactor binding pocket; inhibition site 1133849015972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849015973 catalytic residue [active] 1133849015974 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1133849015975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849015976 putative substrate translocation pore; other site 1133849015977 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1133849015978 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1133849015979 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1133849015980 active site 1133849015981 SAM binding site [chemical binding]; other site 1133849015982 homodimer interface [polypeptide binding]; other site 1133849015983 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1133849015984 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1133849015985 Na binding site [ion binding]; other site 1133849015986 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1133849015987 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1133849015988 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1133849015989 nucleoside/Zn binding site; other site 1133849015990 dimer interface [polypeptide binding]; other site 1133849015991 catalytic motif [active] 1133849015992 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1133849015993 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1133849015994 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1133849015995 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1133849015996 putative active site [active] 1133849015997 putative substrate binding site [chemical binding]; other site 1133849015998 ATP binding site [chemical binding]; other site 1133849015999 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849016000 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1133849016001 active site 1133849016002 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1133849016003 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 1133849016004 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1133849016005 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1133849016006 catalytic triad [active] 1133849016007 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1133849016008 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1133849016009 Walker A motif; other site 1133849016010 homodimer interface [polypeptide binding]; other site 1133849016011 ATP binding site [chemical binding]; other site 1133849016012 hydroxycobalamin binding site [chemical binding]; other site 1133849016013 Walker B motif; other site 1133849016014 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 1133849016015 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1133849016016 Walker A motif; other site 1133849016017 ATP binding site [chemical binding]; other site 1133849016018 Walker B motif; other site 1133849016019 arginine finger; other site 1133849016020 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 1133849016021 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1133849016022 metal ion-dependent adhesion site (MIDAS); other site 1133849016023 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1133849016024 Coenzyme A binding pocket [chemical binding]; other site 1133849016025 malate:quinone oxidoreductase; Validated; Region: PRK05257 1133849016026 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1133849016027 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1133849016028 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1133849016029 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1133849016030 putative active site [active] 1133849016031 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1133849016032 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1133849016033 cobyric acid synthase; Provisional; Region: PRK00784 1133849016034 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1133849016035 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1133849016036 catalytic triad [active] 1133849016037 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1133849016038 active site 1133849016039 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1133849016040 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1133849016041 FMN binding site [chemical binding]; other site 1133849016042 substrate binding site [chemical binding]; other site 1133849016043 putative catalytic residue [active] 1133849016044 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849016045 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1133849016046 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849016047 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1133849016048 acyl-activating enzyme (AAE) consensus motif; other site 1133849016049 acyl-activating enzyme (AAE) consensus motif; other site 1133849016050 putative AMP binding site [chemical binding]; other site 1133849016051 putative active site [active] 1133849016052 putative CoA binding site [chemical binding]; other site 1133849016053 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1133849016054 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1133849016055 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1133849016056 Domain of unknown function (DUF1864); Region: DUF1864; pfam08933 1133849016057 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1133849016058 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1133849016059 Cupin domain; Region: Cupin_2; cl17218 1133849016060 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1133849016061 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1133849016062 DNA-binding site [nucleotide binding]; DNA binding site 1133849016063 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1133849016064 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 1133849016065 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1133849016066 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 1133849016067 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1133849016068 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 1133849016069 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1133849016070 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1133849016071 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849016072 Walker A/P-loop; other site 1133849016073 ATP binding site [chemical binding]; other site 1133849016074 Q-loop/lid; other site 1133849016075 ABC transporter signature motif; other site 1133849016076 Walker B; other site 1133849016077 D-loop; other site 1133849016078 H-loop/switch region; other site 1133849016079 TOBE domain; Region: TOBE_2; pfam08402 1133849016080 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 1133849016081 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849016082 dimer interface [polypeptide binding]; other site 1133849016083 conserved gate region; other site 1133849016084 putative PBP binding loops; other site 1133849016085 ABC-ATPase subunit interface; other site 1133849016086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849016087 dimer interface [polypeptide binding]; other site 1133849016088 conserved gate region; other site 1133849016089 putative PBP binding loops; other site 1133849016090 ABC-ATPase subunit interface; other site 1133849016091 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 1133849016092 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 1133849016093 ribonuclease; Region: Ribonuclease; pfam00545 1133849016094 active site 1133849016095 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849016096 non-specific DNA binding site [nucleotide binding]; other site 1133849016097 salt bridge; other site 1133849016098 sequence-specific DNA binding site [nucleotide binding]; other site 1133849016099 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1133849016100 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1133849016101 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1133849016102 amino acid transporter; Region: 2A0306; TIGR00909 1133849016103 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 1133849016104 short chain dehydrogenase; Provisional; Region: PRK07806 1133849016105 NAD(P) binding site [chemical binding]; other site 1133849016106 active site 1133849016107 Predicted transcriptional regulators [Transcription]; Region: COG1733 1133849016108 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1133849016109 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1133849016110 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1133849016111 DNA binding residues [nucleotide binding] 1133849016112 drug binding residues [chemical binding]; other site 1133849016113 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 1133849016114 beta-clamp/clamp loader binding surface; other site 1133849016115 beta-clamp/translesion DNA polymerase binding surface; other site 1133849016116 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1133849016117 heme-binding site [chemical binding]; other site 1133849016118 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1133849016119 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1133849016120 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1133849016121 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1133849016122 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1133849016123 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 1133849016124 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1133849016125 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1133849016126 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1133849016127 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1133849016128 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1133849016129 active site 1133849016130 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1133849016131 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1133849016132 putative substrate binding region [chemical binding]; other site 1133849016133 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1133849016134 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1133849016135 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1133849016136 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1133849016137 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 1133849016138 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1133849016139 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1133849016140 dimerization interface [polypeptide binding]; other site 1133849016141 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1133849016142 active site residue [active] 1133849016143 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1133849016144 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1133849016145 active site 1133849016146 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1133849016147 AAA domain; Region: AAA_12; pfam13087 1133849016148 HipA N-terminal domain; Region: Couple_hipA; cl11853 1133849016149 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1133849016150 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1133849016151 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1133849016152 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1133849016153 FeS/SAM binding site; other site 1133849016154 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 1133849016155 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1133849016156 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1133849016157 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1133849016158 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1133849016159 hinge region; other site 1133849016160 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1133849016161 putative nucleotide binding site [chemical binding]; other site 1133849016162 uridine monophosphate binding site [chemical binding]; other site 1133849016163 homohexameric interface [polypeptide binding]; other site 1133849016164 elongation factor Ts; Provisional; Region: tsf; PRK09377 1133849016165 UBA/TS-N domain; Region: UBA; pfam00627 1133849016166 Elongation factor TS; Region: EF_TS; pfam00889 1133849016167 Elongation factor TS; Region: EF_TS; pfam00889 1133849016168 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1133849016169 rRNA interaction site [nucleotide binding]; other site 1133849016170 S8 interaction site; other site 1133849016171 putative laminin-1 binding site; other site 1133849016172 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1133849016173 Peptidase family M23; Region: Peptidase_M23; pfam01551 1133849016174 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1133849016175 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849016176 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 1133849016177 Yqey-like protein; Region: YqeY; cl17540 1133849016178 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1133849016179 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1133849016180 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1133849016181 Domain of unknown function (DUF202); Region: DUF202; pfam02656 1133849016182 Domain of unknown function (DUF202); Region: DUF202; cl09954 1133849016183 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 1133849016184 Lipase (class 2); Region: Lipase_2; pfam01674 1133849016185 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849016186 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849016187 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1133849016188 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849016189 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1133849016190 putative substrate translocation pore; other site 1133849016191 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849016192 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1133849016193 Peptidase family M23; Region: Peptidase_M23; pfam01551 1133849016194 Bacterial SH3 domain; Region: SH3_3; cl17532 1133849016195 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1133849016196 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1133849016197 active site 1133849016198 DNA binding site [nucleotide binding] 1133849016199 Int/Topo IB signature motif; other site 1133849016200 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1133849016201 DNA protecting protein DprA; Region: dprA; TIGR00732 1133849016202 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 1133849016203 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1133849016204 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1133849016205 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1133849016206 Walker A motif; other site 1133849016207 ATP binding site [chemical binding]; other site 1133849016208 Walker B motif; other site 1133849016209 arginine finger; other site 1133849016210 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1133849016211 hypothetical protein; Reviewed; Region: PRK12497 1133849016212 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1133849016213 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1133849016214 RNA/DNA hybrid binding site [nucleotide binding]; other site 1133849016215 active site 1133849016216 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1133849016217 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1133849016218 Catalytic site [active] 1133849016219 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 1133849016220 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1133849016221 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1133849016222 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1133849016223 Catalytic site [active] 1133849016224 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 1133849016225 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1133849016226 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1133849016227 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1133849016228 Beta-lactamase; Region: Beta-lactamase; pfam00144 1133849016229 DoxX-like family; Region: DoxX_2; pfam13564 1133849016230 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1133849016231 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849016232 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1133849016233 DNA binding residues [nucleotide binding] 1133849016234 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1133849016235 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1133849016236 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1133849016237 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1133849016238 RNA binding site [nucleotide binding]; other site 1133849016239 AMP-binding domain protein; Validated; Region: PRK08315 1133849016240 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849016241 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1133849016242 acyl-activating enzyme (AAE) consensus motif; other site 1133849016243 putative AMP binding site [chemical binding]; other site 1133849016244 putative active site [active] 1133849016245 putative CoA binding site [chemical binding]; other site 1133849016246 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1133849016247 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849016248 acyl-activating enzyme (AAE) consensus motif; other site 1133849016249 AMP binding site [chemical binding]; other site 1133849016250 active site 1133849016251 CoA binding site [chemical binding]; other site 1133849016252 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849016253 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849016254 DNA binding residues [nucleotide binding] 1133849016255 dimerization interface [polypeptide binding]; other site 1133849016256 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1133849016257 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1133849016258 RimM N-terminal domain; Region: RimM; pfam01782 1133849016259 PRC-barrel domain; Region: PRC; pfam05239 1133849016260 hypothetical protein; Provisional; Region: PRK02821 1133849016261 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1133849016262 G-X-X-G motif; other site 1133849016263 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1133849016264 RibD C-terminal domain; Region: RibD_C; cl17279 1133849016265 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1133849016266 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1133849016267 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1133849016268 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1133849016269 Protein of unknown function (DUF4243); Region: DUF4243; pfam14027 1133849016270 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1133849016271 MarR family; Region: MarR_2; pfam12802 1133849016272 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1133849016273 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1133849016274 active site 1133849016275 signal recognition particle protein; Provisional; Region: PRK10867 1133849016276 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1133849016277 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1133849016278 P loop; other site 1133849016279 GTP binding site [chemical binding]; other site 1133849016280 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 1133849016281 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1133849016282 PII uridylyl-transferase; Provisional; Region: PRK03381 1133849016283 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1133849016284 metal binding triad [ion binding]; metal-binding site 1133849016285 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1133849016286 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1133849016287 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 1133849016288 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1133849016289 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1133849016290 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1133849016291 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1133849016292 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 1133849016293 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1133849016294 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1133849016295 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 1133849016296 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849016297 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849016298 NAD(P) binding site [chemical binding]; other site 1133849016299 active site 1133849016300 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1133849016301 AAA domain; Region: AAA_23; pfam13476 1133849016302 Walker A/P-loop; other site 1133849016303 ATP binding site [chemical binding]; other site 1133849016304 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1133849016305 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1133849016306 ABC transporter signature motif; other site 1133849016307 Walker B; other site 1133849016308 D-loop; other site 1133849016309 H-loop/switch region; other site 1133849016310 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1133849016311 2TM domain; Region: 2TM; pfam13239 1133849016312 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 1133849016313 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1133849016314 NAD binding site [chemical binding]; other site 1133849016315 catalytic Zn binding site [ion binding]; other site 1133849016316 substrate binding site [chemical binding]; other site 1133849016317 structural Zn binding site [ion binding]; other site 1133849016318 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1133849016319 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849016320 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1133849016321 non-specific DNA binding site [nucleotide binding]; other site 1133849016322 salt bridge; other site 1133849016323 sequence-specific DNA binding site [nucleotide binding]; other site 1133849016324 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1133849016325 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1133849016326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849016327 putative substrate translocation pore; other site 1133849016328 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1133849016329 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849016330 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849016331 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1133849016332 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1133849016333 acylphosphatase; Provisional; Region: PRK14422 1133849016334 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1133849016335 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1133849016336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849016337 active site 1133849016338 phosphorylation site [posttranslational modification] 1133849016339 intermolecular recognition site; other site 1133849016340 dimerization interface [polypeptide binding]; other site 1133849016341 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1133849016342 DNA binding site [nucleotide binding] 1133849016343 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1133849016344 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1133849016345 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1133849016346 Ligand Binding Site [chemical binding]; other site 1133849016347 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1133849016348 dimer interface [polypeptide binding]; other site 1133849016349 phosphorylation site [posttranslational modification] 1133849016350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849016351 ATP binding site [chemical binding]; other site 1133849016352 Mg2+ binding site [ion binding]; other site 1133849016353 G-X-G motif; other site 1133849016354 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1133849016355 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1133849016356 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1133849016357 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1133849016358 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1133849016359 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1133849016360 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1133849016361 active site 1133849016362 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1133849016363 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1133849016364 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 1133849016365 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1133849016366 Moco binding site; other site 1133849016367 metal coordination site [ion binding]; other site 1133849016368 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1133849016369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849016370 S-adenosylmethionine binding site [chemical binding]; other site 1133849016371 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 1133849016372 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1133849016373 Ligand binding site; other site 1133849016374 Putative Catalytic site; other site 1133849016375 DXD motif; other site 1133849016376 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1133849016377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849016378 active site 1133849016379 phosphorylation site [posttranslational modification] 1133849016380 intermolecular recognition site; other site 1133849016381 dimerization interface [polypeptide binding]; other site 1133849016382 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1133849016383 DNA binding site [nucleotide binding] 1133849016384 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1133849016385 dimer interface [polypeptide binding]; other site 1133849016386 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1133849016387 phosphorylation site [posttranslational modification] 1133849016388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849016389 ATP binding site [chemical binding]; other site 1133849016390 Mg2+ binding site [ion binding]; other site 1133849016391 G-X-G motif; other site 1133849016392 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1133849016393 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849016394 NAD(P) binding site [chemical binding]; other site 1133849016395 active site 1133849016396 hypothetical protein; Provisional; Region: PRK07758 1133849016397 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1133849016398 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1133849016399 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1133849016400 PBP superfamily domain; Region: PBP_like_2; cl17296 1133849016401 hypothetical protein; Provisional; Region: PRK07945 1133849016402 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1133849016403 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1133849016404 active site 1133849016405 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1133849016406 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 1133849016407 NADP+ binding site [chemical binding]; other site 1133849016408 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1133849016409 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1133849016410 DNA binding site [nucleotide binding] 1133849016411 catalytic residue [active] 1133849016412 H2TH interface [polypeptide binding]; other site 1133849016413 putative catalytic residues [active] 1133849016414 turnover-facilitating residue; other site 1133849016415 intercalation triad [nucleotide binding]; other site 1133849016416 8OG recognition residue [nucleotide binding]; other site 1133849016417 putative reading head residues; other site 1133849016418 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1133849016419 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1133849016420 ribonuclease III; Reviewed; Region: rnc; PRK00102 1133849016421 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1133849016422 dimerization interface [polypeptide binding]; other site 1133849016423 active site 1133849016424 metal binding site [ion binding]; metal-binding site 1133849016425 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1133849016426 dsRNA binding site [nucleotide binding]; other site 1133849016427 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1133849016428 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1133849016429 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1133849016430 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1133849016431 GtrA-like protein; Region: GtrA; pfam04138 1133849016432 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1133849016433 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1133849016434 active site 1133849016435 (T/H)XGH motif; other site 1133849016436 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1133849016437 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849016438 S-adenosylmethionine binding site [chemical binding]; other site 1133849016439 pyruvate carboxylase; Reviewed; Region: PRK12999 1133849016440 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1133849016441 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1133849016442 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1133849016443 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1133849016444 active site 1133849016445 catalytic residues [active] 1133849016446 metal binding site [ion binding]; metal-binding site 1133849016447 homodimer binding site [polypeptide binding]; other site 1133849016448 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1133849016449 carboxyltransferase (CT) interaction site; other site 1133849016450 biotinylation site [posttranslational modification]; other site 1133849016451 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1133849016452 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1133849016453 THF binding site; other site 1133849016454 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1133849016455 substrate binding site [chemical binding]; other site 1133849016456 THF binding site; other site 1133849016457 zinc-binding site [ion binding]; other site 1133849016458 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1133849016459 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 1133849016460 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1133849016461 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849016462 sequence-specific DNA binding site [nucleotide binding]; other site 1133849016463 salt bridge; other site 1133849016464 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1133849016465 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1133849016466 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1133849016467 SnoaL-like domain; Region: SnoaL_3; pfam13474 1133849016468 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1133849016469 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1133849016470 generic binding surface II; other site 1133849016471 ssDNA binding site; other site 1133849016472 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1133849016473 ATP binding site [chemical binding]; other site 1133849016474 putative Mg++ binding site [ion binding]; other site 1133849016475 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1133849016476 nucleotide binding region [chemical binding]; other site 1133849016477 ATP-binding site [chemical binding]; other site 1133849016478 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1133849016479 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1133849016480 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1133849016481 enoyl-CoA hydratase; Provisional; Region: PRK06688 1133849016482 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1133849016483 substrate binding site [chemical binding]; other site 1133849016484 oxyanion hole (OAH) forming residues; other site 1133849016485 trimer interface [polypeptide binding]; other site 1133849016486 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1133849016487 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849016488 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1133849016489 ligand binding site [chemical binding]; other site 1133849016490 active site 1133849016491 UGI interface [polypeptide binding]; other site 1133849016492 catalytic site [active] 1133849016493 thiamine monophosphate kinase; Provisional; Region: PRK05731 1133849016494 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1133849016495 ATP binding site [chemical binding]; other site 1133849016496 dimerization interface [polypeptide binding]; other site 1133849016497 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1133849016498 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1133849016499 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1133849016500 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1133849016501 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1133849016502 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1133849016503 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1133849016504 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1133849016505 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1133849016506 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1133849016507 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 1133849016508 polyphosphate kinase; Provisional; Region: PRK05443 1133849016509 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1133849016510 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1133849016511 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1133849016512 putative domain interface [polypeptide binding]; other site 1133849016513 putative active site [active] 1133849016514 catalytic site [active] 1133849016515 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1133849016516 putative domain interface [polypeptide binding]; other site 1133849016517 putative active site [active] 1133849016518 catalytic site [active] 1133849016519 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1133849016520 active site 1133849016521 Ap6A binding site [chemical binding]; other site 1133849016522 nudix motif; other site 1133849016523 metal binding site [ion binding]; metal-binding site 1133849016524 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1133849016525 catalytic core [active] 1133849016526 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1133849016527 IHF - DNA interface [nucleotide binding]; other site 1133849016528 IHF dimer interface [polypeptide binding]; other site 1133849016529 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1133849016530 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1133849016531 substrate binding site [chemical binding]; other site 1133849016532 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1133849016533 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1133849016534 substrate binding site [chemical binding]; other site 1133849016535 ligand binding site [chemical binding]; other site 1133849016536 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1133849016537 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1133849016538 Bacterial transcriptional regulator; Region: IclR; pfam01614 1133849016539 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1133849016540 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1133849016541 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1133849016542 HIGH motif; other site 1133849016543 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1133849016544 active site 1133849016545 KMSKS motif; other site 1133849016546 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1133849016547 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1133849016548 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1133849016549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849016550 putative substrate translocation pore; other site 1133849016551 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1133849016552 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1133849016553 putative active site [active] 1133849016554 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1133849016555 tartrate dehydrogenase; Region: TTC; TIGR02089 1133849016556 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1133849016557 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1133849016558 ligand binding site [chemical binding]; other site 1133849016559 NAD binding site [chemical binding]; other site 1133849016560 dimerization interface [polypeptide binding]; other site 1133849016561 catalytic site [active] 1133849016562 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1133849016563 putative L-serine binding site [chemical binding]; other site 1133849016564 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1133849016565 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1133849016566 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1133849016567 dimerization interface [polypeptide binding]; other site 1133849016568 substrate binding pocket [chemical binding]; other site 1133849016569 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1133849016570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849016571 putative substrate translocation pore; other site 1133849016572 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 1133849016573 Predicted transcriptional regulators [Transcription]; Region: COG1733 1133849016574 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1133849016575 RibD C-terminal domain; Region: RibD_C; cl17279 1133849016576 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1133849016577 DNA-binding site [nucleotide binding]; DNA binding site 1133849016578 RNA-binding motif; other site 1133849016579 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1133849016580 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1133849016581 dimer interface [polypeptide binding]; other site 1133849016582 PYR/PP interface [polypeptide binding]; other site 1133849016583 TPP binding site [chemical binding]; other site 1133849016584 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1133849016585 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1133849016586 TPP-binding site [chemical binding]; other site 1133849016587 KduI/IolB family; Region: KduI; pfam04962 1133849016588 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1133849016589 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1133849016590 substrate binding site [chemical binding]; other site 1133849016591 ATP binding site [chemical binding]; other site 1133849016592 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1133849016593 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1133849016594 Walker A/P-loop; other site 1133849016595 ATP binding site [chemical binding]; other site 1133849016596 Q-loop/lid; other site 1133849016597 ABC transporter signature motif; other site 1133849016598 Walker B; other site 1133849016599 D-loop; other site 1133849016600 H-loop/switch region; other site 1133849016601 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1133849016602 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1133849016603 TM-ABC transporter signature motif; other site 1133849016604 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1133849016605 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 1133849016606 putative ligand binding site [chemical binding]; other site 1133849016607 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1133849016608 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1133849016609 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1133849016610 DNA binding site [nucleotide binding] 1133849016611 domain linker motif; other site 1133849016612 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1133849016613 dimerization interface [polypeptide binding]; other site 1133849016614 ligand binding site [chemical binding]; other site 1133849016615 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1133849016616 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1133849016617 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1133849016618 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1133849016619 ATP binding site [chemical binding]; other site 1133849016620 putative Mg++ binding site [ion binding]; other site 1133849016621 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1133849016622 nucleotide binding region [chemical binding]; other site 1133849016623 ATP-binding site [chemical binding]; other site 1133849016624 NgoMIV restriction enzyme; Region: NgoMIV_restric; pfam09015 1133849016625 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1133849016626 additional DNA contacts [nucleotide binding]; other site 1133849016627 mismatch recognition site; other site 1133849016628 active site 1133849016629 zinc binding site [ion binding]; other site 1133849016630 DNA intercalation site [nucleotide binding]; other site 1133849016631 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1133849016632 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 1133849016633 cofactor binding site; other site 1133849016634 DNA binding site [nucleotide binding] 1133849016635 substrate interaction site [chemical binding]; other site 1133849016636 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1133849016637 metal ion-dependent adhesion site (MIDAS); other site 1133849016638 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1133849016639 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1133849016640 Walker A motif; other site 1133849016641 ATP binding site [chemical binding]; other site 1133849016642 Walker B motif; other site 1133849016643 arginine finger; other site 1133849016644 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1133849016645 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1133849016646 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1133849016647 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1133849016648 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1133849016649 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1133849016650 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1133849016651 putative valine binding site [chemical binding]; other site 1133849016652 dimer interface [polypeptide binding]; other site 1133849016653 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1133849016654 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1133849016655 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1133849016656 PYR/PP interface [polypeptide binding]; other site 1133849016657 dimer interface [polypeptide binding]; other site 1133849016658 TPP binding site [chemical binding]; other site 1133849016659 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1133849016660 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1133849016661 TPP-binding site [chemical binding]; other site 1133849016662 dimer interface [polypeptide binding]; other site 1133849016663 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1133849016664 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1133849016665 Predicted membrane protein [Function unknown]; Region: COG2259 1133849016666 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1133849016667 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1133849016668 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1133849016669 GatB domain; Region: GatB_Yqey; smart00845 1133849016670 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849016671 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1133849016672 6-phosphofructokinase; Provisional; Region: PRK03202 1133849016673 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1133849016674 active site 1133849016675 ADP/pyrophosphate binding site [chemical binding]; other site 1133849016676 dimerization interface [polypeptide binding]; other site 1133849016677 allosteric effector site; other site 1133849016678 fructose-1,6-bisphosphate binding site; other site 1133849016679 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1133849016680 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1133849016681 active site 1133849016682 ATP binding site [chemical binding]; other site 1133849016683 substrate binding site [chemical binding]; other site 1133849016684 activation loop (A-loop); other site 1133849016685 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1133849016686 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1133849016687 active site 1133849016688 ATP binding site [chemical binding]; other site 1133849016689 substrate binding site [chemical binding]; other site 1133849016690 activation loop (A-loop); other site 1133849016691 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849016692 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849016693 active site 1133849016694 phosphorylation site [posttranslational modification] 1133849016695 intermolecular recognition site; other site 1133849016696 dimerization interface [polypeptide binding]; other site 1133849016697 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849016698 DNA binding residues [nucleotide binding] 1133849016699 dimerization interface [polypeptide binding]; other site 1133849016700 Histidine kinase; Region: HisKA_3; pfam07730 1133849016701 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849016702 ATP binding site [chemical binding]; other site 1133849016703 Mg2+ binding site [ion binding]; other site 1133849016704 G-X-G motif; other site 1133849016705 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1133849016706 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1133849016707 Walker A/P-loop; other site 1133849016708 ATP binding site [chemical binding]; other site 1133849016709 Q-loop/lid; other site 1133849016710 ABC transporter signature motif; other site 1133849016711 Walker B; other site 1133849016712 D-loop; other site 1133849016713 H-loop/switch region; other site 1133849016714 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1133849016715 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1133849016716 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1133849016717 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1133849016718 active site 1133849016719 ATP binding site [chemical binding]; other site 1133849016720 substrate binding site [chemical binding]; other site 1133849016721 activation loop (A-loop); other site 1133849016722 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1133849016723 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849016724 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849016725 active site 1133849016726 phosphorylation site [posttranslational modification] 1133849016727 intermolecular recognition site; other site 1133849016728 dimerization interface [polypeptide binding]; other site 1133849016729 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849016730 dimerization interface [polypeptide binding]; other site 1133849016731 DNA binding residues [nucleotide binding] 1133849016732 Histidine kinase; Region: HisKA_3; pfam07730 1133849016733 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849016734 ATP binding site [chemical binding]; other site 1133849016735 Mg2+ binding site [ion binding]; other site 1133849016736 G-X-G motif; other site 1133849016737 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1133849016738 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 1133849016739 putative hydrophobic ligand binding site [chemical binding]; other site 1133849016740 short chain dehydrogenase; Provisional; Region: PRK08263 1133849016741 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1133849016742 NADP binding site [chemical binding]; other site 1133849016743 active site 1133849016744 steroid binding site; other site 1133849016745 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1133849016746 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1133849016747 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1133849016748 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1133849016749 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1133849016750 Coenzyme A binding pocket [chemical binding]; other site 1133849016751 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1133849016752 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1133849016753 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1133849016754 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1133849016755 active site 1133849016756 TDP-binding site; other site 1133849016757 acceptor substrate-binding pocket; other site 1133849016758 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1133849016759 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1133849016760 conserved cys residue [active] 1133849016761 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1133849016762 MgtE intracellular N domain; Region: MgtE_N; smart00924 1133849016763 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1133849016764 Divalent cation transporter; Region: MgtE; pfam01769 1133849016765 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1133849016766 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1133849016767 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1133849016768 Mg++ binding site [ion binding]; other site 1133849016769 putative catalytic motif [active] 1133849016770 putative substrate binding site [chemical binding]; other site 1133849016771 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849016772 dimerization interface [polypeptide binding]; other site 1133849016773 putative DNA binding site [nucleotide binding]; other site 1133849016774 putative Zn2+ binding site [ion binding]; other site 1133849016775 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 1133849016776 putative hydrophobic ligand binding site [chemical binding]; other site 1133849016777 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1133849016778 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1133849016779 Coenzyme A binding pocket [chemical binding]; other site 1133849016780 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1133849016781 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1133849016782 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1133849016783 dimer interface [polypeptide binding]; other site 1133849016784 putative radical transfer pathway; other site 1133849016785 diiron center [ion binding]; other site 1133849016786 tyrosyl radical; other site 1133849016787 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1133849016788 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1133849016789 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1133849016790 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1133849016791 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849016792 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1133849016793 Walker A/P-loop; other site 1133849016794 ATP binding site [chemical binding]; other site 1133849016795 Q-loop/lid; other site 1133849016796 ABC transporter signature motif; other site 1133849016797 Walker B; other site 1133849016798 D-loop; other site 1133849016799 H-loop/switch region; other site 1133849016800 Condensation domain; Region: Condensation; pfam00668 1133849016801 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849016802 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1133849016803 acyl-activating enzyme (AAE) consensus motif; other site 1133849016804 AMP binding site [chemical binding]; other site 1133849016805 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849016806 Condensation domain; Region: Condensation; pfam00668 1133849016807 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1133849016808 Condensation domain; Region: Condensation; pfam00668 1133849016809 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849016810 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1133849016811 acyl-activating enzyme (AAE) consensus motif; other site 1133849016812 AMP binding site [chemical binding]; other site 1133849016813 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849016814 Condensation domain; Region: Condensation; pfam00668 1133849016815 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849016816 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849016817 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1133849016818 acyl-activating enzyme (AAE) consensus motif; other site 1133849016819 AMP binding site [chemical binding]; other site 1133849016820 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849016821 Condensation domain; Region: Condensation; pfam00668 1133849016822 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1133849016823 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1133849016824 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849016825 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1133849016826 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1133849016827 intersubunit interface [polypeptide binding]; other site 1133849016828 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1133849016829 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1133849016830 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849016831 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1133849016832 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1133849016833 D-pathway; other site 1133849016834 Putative ubiquinol binding site [chemical binding]; other site 1133849016835 Low-spin heme (heme b) binding site [chemical binding]; other site 1133849016836 Putative water exit pathway; other site 1133849016837 Binuclear center (heme o3/CuB) [ion binding]; other site 1133849016838 K-pathway; other site 1133849016839 Putative proton exit pathway; other site 1133849016840 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1133849016841 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1133849016842 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1133849016843 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1133849016844 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1133849016845 motif II; other site 1133849016846 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 1133849016847 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 1133849016848 dimer interface [polypeptide binding]; other site 1133849016849 putative active site [active] 1133849016850 Endomembrane protein 70; Region: EMP70; pfam02990 1133849016851 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 1133849016852 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849016853 Walker A/P-loop; other site 1133849016854 ATP binding site [chemical binding]; other site 1133849016855 Q-loop/lid; other site 1133849016856 ABC transporter signature motif; other site 1133849016857 Walker B; other site 1133849016858 D-loop; other site 1133849016859 H-loop/switch region; other site 1133849016860 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1133849016861 nudix motif; other site 1133849016862 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1133849016863 trimer interface [polypeptide binding]; other site 1133849016864 oxyanion hole (OAH) forming residues; other site 1133849016865 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849016866 S-adenosylmethionine binding site [chemical binding]; other site 1133849016867 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 1133849016868 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1133849016869 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1133849016870 trimer interface [polypeptide binding]; other site 1133849016871 active site 1133849016872 substrate binding site [chemical binding]; other site 1133849016873 CoA binding site [chemical binding]; other site 1133849016874 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1133849016875 Trp docking motif [polypeptide binding]; other site 1133849016876 active site 1133849016877 PQQ-like domain; Region: PQQ_2; pfam13360 1133849016878 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1133849016879 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1133849016880 Uncharacterized conserved protein [Function unknown]; Region: COG1543 1133849016881 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1133849016882 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 1133849016883 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1133849016884 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849016885 S-adenosylmethionine binding site [chemical binding]; other site 1133849016886 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1133849016887 Ligand binding site [chemical binding]; other site 1133849016888 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1133849016889 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1133849016890 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1133849016891 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1133849016892 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1133849016893 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1133849016894 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1133849016895 dimerization interface [polypeptide binding]; other site 1133849016896 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1133849016897 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1133849016898 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1133849016899 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1133849016900 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1133849016901 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1133849016902 putative acyl-acceptor binding pocket; other site 1133849016903 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1133849016904 Secretory lipase; Region: LIP; pfam03583 1133849016905 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1133849016906 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1133849016907 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849016908 catalytic residue [active] 1133849016909 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1133849016910 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1133849016911 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 1133849016912 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1133849016913 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1133849016914 nucleotide binding pocket [chemical binding]; other site 1133849016915 K-X-D-G motif; other site 1133849016916 catalytic site [active] 1133849016917 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1133849016918 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1133849016919 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1133849016920 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1133849016921 Dimer interface [polypeptide binding]; other site 1133849016922 BRCT sequence motif; other site 1133849016923 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1133849016924 classical (c) SDRs; Region: SDR_c; cd05233 1133849016925 NAD(P) binding site [chemical binding]; other site 1133849016926 active site 1133849016927 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 1133849016928 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1133849016929 AAA domain; Region: AAA_21; pfam13304 1133849016930 AAA domain; Region: AAA_21; pfam13304 1133849016931 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1133849016932 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1133849016933 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1133849016934 active site 1133849016935 dimer interface [polypeptide binding]; other site 1133849016936 catalytic residues [active] 1133849016937 effector binding site; other site 1133849016938 R2 peptide binding site; other site 1133849016939 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1133849016940 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1133849016941 catalytic residues [active] 1133849016942 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1133849016943 Predicted flavoprotein [General function prediction only]; Region: COG0431 1133849016944 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849016945 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849016946 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1133849016947 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1133849016948 homodimer interface [polypeptide binding]; other site 1133849016949 NAD binding pocket [chemical binding]; other site 1133849016950 ATP binding pocket [chemical binding]; other site 1133849016951 Mg binding site [ion binding]; other site 1133849016952 active-site loop [active] 1133849016953 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1133849016954 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849016955 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1133849016956 YCII-related domain; Region: YCII; cl00999 1133849016957 YCII-related domain; Region: YCII; cl00999 1133849016958 YCII-related domain; Region: YCII; cl00999 1133849016959 YCII-related domain; Region: YCII; cl00999 1133849016960 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1133849016961 MoaE interaction surface [polypeptide binding]; other site 1133849016962 MoeB interaction surface [polypeptide binding]; other site 1133849016963 thiocarboxylated glycine; other site 1133849016964 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1133849016965 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1133849016966 FeS/SAM binding site; other site 1133849016967 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1133849016968 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1133849016969 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1133849016970 dimer interface [polypeptide binding]; other site 1133849016971 putative functional site; other site 1133849016972 putative MPT binding site; other site 1133849016973 molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364 1133849016974 bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604 1133849016975 trimer interface [polypeptide binding]; other site 1133849016976 dimer interface [polypeptide binding]; other site 1133849016977 putative active site [active] 1133849016978 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1133849016979 MPT binding site; other site 1133849016980 trimer interface [polypeptide binding]; other site 1133849016981 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1133849016982 MoaE homodimer interface [polypeptide binding]; other site 1133849016983 MoaD interaction [polypeptide binding]; other site 1133849016984 active site residues [active] 1133849016985 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1133849016986 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1133849016987 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1133849016988 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1133849016989 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1133849016990 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1133849016991 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1133849016992 active site 1133849016993 metal binding site [ion binding]; metal-binding site 1133849016994 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 1133849016995 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849016996 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1133849016997 DNA binding residues [nucleotide binding] 1133849016998 short chain dehydrogenase; Provisional; Region: PRK08251 1133849016999 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849017000 NAD(P) binding site [chemical binding]; other site 1133849017001 active site 1133849017002 transcription termination factor Rho; Provisional; Region: PRK12608 1133849017003 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1133849017004 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1133849017005 Walker A motif; other site 1133849017006 ATP binding site [chemical binding]; other site 1133849017007 Walker B motif; other site 1133849017008 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849017009 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1133849017010 putative substrate translocation pore; other site 1133849017011 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1133849017012 CoenzymeA binding site [chemical binding]; other site 1133849017013 subunit interaction site [polypeptide binding]; other site 1133849017014 PHB binding site; other site 1133849017015 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849017016 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849017017 WHG domain; Region: WHG; pfam13305 1133849017018 SnoaL-like domain; Region: SnoaL_2; pfam12680 1133849017019 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1133849017020 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1133849017021 active site 1133849017022 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1133849017023 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1133849017024 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849017025 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1133849017026 Enoylreductase; Region: PKS_ER; smart00829 1133849017027 NAD(P) binding site [chemical binding]; other site 1133849017028 KR domain; Region: KR; pfam08659 1133849017029 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849017030 NAD(P) binding site [chemical binding]; other site 1133849017031 active site 1133849017032 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1133849017033 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1133849017034 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1133849017035 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849017036 catalytic residue [active] 1133849017037 Family description; Region: VCBS; pfam13517 1133849017038 Family description; Region: VCBS; pfam13517 1133849017039 Family description; Region: VCBS; pfam13517 1133849017040 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 1133849017041 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1133849017042 Protein of unknown function (DUF1702); Region: DUF1702; pfam08012 1133849017043 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849017044 NAD(P) binding site [chemical binding]; other site 1133849017045 active site 1133849017046 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849017047 WHG domain; Region: WHG; pfam13305 1133849017048 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1133849017049 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849017050 active site 1133849017051 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1133849017052 Histidine kinase; Region: HisKA_3; pfam07730 1133849017053 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849017054 ATP binding site [chemical binding]; other site 1133849017055 Mg2+ binding site [ion binding]; other site 1133849017056 G-X-G motif; other site 1133849017057 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849017058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849017059 active site 1133849017060 phosphorylation site [posttranslational modification] 1133849017061 intermolecular recognition site; other site 1133849017062 dimerization interface [polypeptide binding]; other site 1133849017063 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849017064 dimerization interface [polypeptide binding]; other site 1133849017065 DNA binding residues [nucleotide binding] 1133849017066 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1133849017067 active site 1133849017068 catalytic triad [active] 1133849017069 dimer interface [polypeptide binding]; other site 1133849017070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849017071 metabolite-proton symporter; Region: 2A0106; TIGR00883 1133849017072 putative substrate translocation pore; other site 1133849017073 short chain dehydrogenase; Provisional; Region: PRK06057 1133849017074 classical (c) SDRs; Region: SDR_c; cd05233 1133849017075 NAD(P) binding site [chemical binding]; other site 1133849017076 active site 1133849017077 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1133849017078 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 1133849017079 NAD(P) binding site [chemical binding]; other site 1133849017080 catalytic residues [active] 1133849017081 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1133849017082 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1133849017083 catalytic triad [active] 1133849017084 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1133849017085 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1133849017086 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1133849017087 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1133849017088 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1133849017089 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1133849017090 Secretory lipase; Region: LIP; pfam03583 1133849017091 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1133849017092 Lipase (class 2); Region: Lipase_2; pfam01674 1133849017093 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1133849017094 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1133849017095 DNA binding residues [nucleotide binding] 1133849017096 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1133849017097 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1133849017098 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1133849017099 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1133849017100 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849017101 dimer interface [polypeptide binding]; other site 1133849017102 conserved gate region; other site 1133849017103 putative PBP binding loops; other site 1133849017104 ABC-ATPase subunit interface; other site 1133849017105 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1133849017106 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849017107 Walker A/P-loop; other site 1133849017108 ATP binding site [chemical binding]; other site 1133849017109 Q-loop/lid; other site 1133849017110 ABC transporter signature motif; other site 1133849017111 Walker B; other site 1133849017112 D-loop; other site 1133849017113 H-loop/switch region; other site 1133849017114 TOBE domain; Region: TOBE; pfam03459 1133849017115 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 1133849017116 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1133849017117 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1133849017118 dimer interface [polypeptide binding]; other site 1133849017119 active site 1133849017120 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1133849017121 putative active site [active] 1133849017122 putative substrate binding site [chemical binding]; other site 1133849017123 ATP binding site [chemical binding]; other site 1133849017124 short chain dehydrogenase; Provisional; Region: PRK07326 1133849017125 classical (c) SDRs; Region: SDR_c; cd05233 1133849017126 NAD(P) binding site [chemical binding]; other site 1133849017127 active site 1133849017128 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1133849017129 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1133849017130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849017131 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1133849017132 putative substrate translocation pore; other site 1133849017133 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1133849017134 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1133849017135 CoenzymeA binding site [chemical binding]; other site 1133849017136 subunit interaction site [polypeptide binding]; other site 1133849017137 PHB binding site; other site 1133849017138 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1133849017139 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1133849017140 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1133849017141 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 1133849017142 BCCT family transporter; Region: BCCT; pfam02028 1133849017143 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849017144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849017145 active site 1133849017146 phosphorylation site [posttranslational modification] 1133849017147 intermolecular recognition site; other site 1133849017148 dimerization interface [polypeptide binding]; other site 1133849017149 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849017150 DNA binding residues [nucleotide binding] 1133849017151 dimerization interface [polypeptide binding]; other site 1133849017152 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1133849017153 Histidine kinase; Region: HisKA_3; pfam07730 1133849017154 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1133849017155 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1133849017156 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1133849017157 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 1133849017158 putative metal binding site [ion binding]; other site 1133849017159 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1133849017160 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 1133849017161 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 1133849017162 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849017163 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1133849017164 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1133849017165 DNA binding residues [nucleotide binding] 1133849017166 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1133849017167 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1133849017168 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1133849017169 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1133849017170 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493 1133849017171 Na binding site [ion binding]; other site 1133849017172 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1133849017173 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1133849017174 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1133849017175 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1133849017176 putative active site [active] 1133849017177 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1133849017178 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1133849017179 putative active site [active] 1133849017180 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1133849017181 PLD-like domain; Region: PLDc_2; pfam13091 1133849017182 putative active site [active] 1133849017183 catalytic site [active] 1133849017184 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1133849017185 nucleotide binding site [chemical binding]; other site 1133849017186 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1133849017187 Peptidase family M23; Region: Peptidase_M23; pfam01551 1133849017188 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1133849017189 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1133849017190 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 1133849017191 putative heme binding pocket [chemical binding]; other site 1133849017192 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1133849017193 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1133849017194 PYR/PP interface [polypeptide binding]; other site 1133849017195 dimer interface [polypeptide binding]; other site 1133849017196 TPP binding site [chemical binding]; other site 1133849017197 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1133849017198 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1133849017199 TPP-binding site [chemical binding]; other site 1133849017200 enoyl-CoA hydratase; Provisional; Region: PRK06494 1133849017201 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1133849017202 substrate binding site [chemical binding]; other site 1133849017203 oxyanion hole (OAH) forming residues; other site 1133849017204 trimer interface [polypeptide binding]; other site 1133849017205 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1133849017206 substrate binding site [chemical binding]; other site 1133849017207 oxyanion hole (OAH) forming residues; other site 1133849017208 trimer interface [polypeptide binding]; other site 1133849017209 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1133849017210 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1133849017211 trimer interface [polypeptide binding]; other site 1133849017212 oxyanion hole (OAH) forming residues; other site 1133849017213 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1133849017214 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1133849017215 malonyl-CoA binding site [chemical binding]; other site 1133849017216 dimer interface [polypeptide binding]; other site 1133849017217 active site 1133849017218 product binding site; other site 1133849017219 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849017220 Cytochrome P450; Region: p450; cl12078 1133849017221 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1133849017222 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 1133849017223 active site 1133849017224 catalytic residues [active] 1133849017225 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1133849017226 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1133849017227 putative active site [active] 1133849017228 putative metal binding site [ion binding]; other site 1133849017229 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1133849017230 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1133849017231 ligand binding site [chemical binding]; other site 1133849017232 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1133849017233 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1133849017234 Walker A/P-loop; other site 1133849017235 ATP binding site [chemical binding]; other site 1133849017236 Q-loop/lid; other site 1133849017237 ABC transporter signature motif; other site 1133849017238 Walker B; other site 1133849017239 D-loop; other site 1133849017240 H-loop/switch region; other site 1133849017241 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1133849017242 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1133849017243 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1133849017244 TM-ABC transporter signature motif; other site 1133849017245 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1133849017246 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1133849017247 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1133849017248 TM-ABC transporter signature motif; other site 1133849017249 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1133849017250 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1133849017251 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1133849017252 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1133849017253 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1133849017254 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1133849017255 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1133849017256 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1133849017257 apolar tunnel; other site 1133849017258 heme binding site [chemical binding]; other site 1133849017259 dimerization interface [polypeptide binding]; other site 1133849017260 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1133849017261 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1133849017262 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1133849017263 putative active site [active] 1133849017264 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1133849017265 EamA-like transporter family; Region: EamA; pfam00892 1133849017266 EamA-like transporter family; Region: EamA; pfam00892 1133849017267 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1133849017268 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849017269 putative DNA binding site [nucleotide binding]; other site 1133849017270 putative Zn2+ binding site [ion binding]; other site 1133849017271 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1133849017272 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1133849017273 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1133849017274 catalytic residues [active] 1133849017275 Secretory lipase; Region: LIP; pfam03583 1133849017276 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1133849017277 DinB superfamily; Region: DinB_2; pfam12867 1133849017278 WHG domain; Region: WHG; pfam13305 1133849017279 Amidohydrolase; Region: Amidohydro_2; pfam04909 1133849017280 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844 1133849017281 active site 1133849017282 catalytic triad [active] 1133849017283 oxyanion hole [active] 1133849017284 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1133849017285 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1133849017286 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1133849017287 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1133849017288 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1133849017289 dimerization interface [polypeptide binding]; other site 1133849017290 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849017291 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1133849017292 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1133849017293 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849017294 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1133849017295 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1133849017296 Isochorismatase family; Region: Isochorismatase; pfam00857 1133849017297 catalytic triad [active] 1133849017298 conserved cis-peptide bond; other site 1133849017299 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849017300 NAD(P) binding site [chemical binding]; other site 1133849017301 active site 1133849017302 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1133849017303 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1133849017304 acyl-activating enzyme (AAE) consensus motif; other site 1133849017305 active site 1133849017306 AMP binding site [chemical binding]; other site 1133849017307 substrate binding site [chemical binding]; other site 1133849017308 enterobactin exporter EntS; Provisional; Region: PRK10489 1133849017309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849017310 putative substrate translocation pore; other site 1133849017311 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 1133849017312 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1133849017313 intersubunit interface [polypeptide binding]; other site 1133849017314 Condensation domain; Region: Condensation; pfam00668 1133849017315 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849017316 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1133849017317 acyl-activating enzyme (AAE) consensus motif; other site 1133849017318 AMP binding site [chemical binding]; other site 1133849017319 Condensation domain; Region: Condensation; pfam00668 1133849017320 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1133849017321 Condensation domain; Region: Condensation; pfam00668 1133849017322 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849017323 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849017324 Condensation domain; Region: Condensation; pfam00668 1133849017325 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849017326 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849017327 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849017328 acyl-activating enzyme (AAE) consensus motif; other site 1133849017329 AMP binding site [chemical binding]; other site 1133849017330 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849017331 Condensation domain; Region: Condensation; pfam00668 1133849017332 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849017333 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849017334 acyl-activating enzyme (AAE) consensus motif; other site 1133849017335 AMP binding site [chemical binding]; other site 1133849017336 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849017337 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1133849017338 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1133849017339 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1133849017340 FAD binding pocket [chemical binding]; other site 1133849017341 FAD binding motif [chemical binding]; other site 1133849017342 phosphate binding motif [ion binding]; other site 1133849017343 NAD binding pocket [chemical binding]; other site 1133849017344 Purine nucleoside permease (NUP); Region: NUP; cl17832 1133849017345 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1133849017346 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1133849017347 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1133849017348 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1133849017349 Beta-lactamase; Region: Beta-lactamase; pfam00144 1133849017350 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1133849017351 active site 1133849017352 catalytic residues [active] 1133849017353 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1133849017354 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849017355 S-adenosylmethionine binding site [chemical binding]; other site 1133849017356 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1133849017357 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1133849017358 dimerization interface [polypeptide binding]; other site 1133849017359 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1133849017360 dimer interface [polypeptide binding]; other site 1133849017361 phosphorylation site [posttranslational modification] 1133849017362 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849017363 ATP binding site [chemical binding]; other site 1133849017364 Mg2+ binding site [ion binding]; other site 1133849017365 G-X-G motif; other site 1133849017366 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1133849017367 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849017368 active site 1133849017369 phosphorylation site [posttranslational modification] 1133849017370 intermolecular recognition site; other site 1133849017371 dimerization interface [polypeptide binding]; other site 1133849017372 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1133849017373 DNA binding site [nucleotide binding] 1133849017374 TAP-like protein; Region: Abhydrolase_4; pfam08386 1133849017375 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1133849017376 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 1133849017377 putative catalytic site [active] 1133849017378 metal binding site A [ion binding]; metal-binding site 1133849017379 phosphate binding site [ion binding]; other site 1133849017380 metal binding site C [ion binding]; metal-binding site 1133849017381 metal binding site B [ion binding]; metal-binding site 1133849017382 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1133849017383 active site 1133849017384 Lsr2; Region: Lsr2; pfam11774 1133849017385 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1133849017386 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1133849017387 AMP nucleosidase; Provisional; Region: PRK08292 1133849017388 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1133849017389 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1133849017390 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1133849017391 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1133849017392 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1133849017393 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1133849017394 Uncharacterized conserved protein [Function unknown]; Region: COG5276 1133849017395 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1133849017396 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 1133849017397 tetramer interface [polypeptide binding]; other site 1133849017398 active site 1133849017399 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1133849017400 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1133849017401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849017402 putative substrate translocation pore; other site 1133849017403 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1133849017404 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1133849017405 dimer interface [polypeptide binding]; other site 1133849017406 active site 1133849017407 CoA binding pocket [chemical binding]; other site 1133849017408 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1133849017409 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1133849017410 hydrophobic ligand binding site; other site 1133849017411 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1133849017412 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 1133849017413 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1133849017414 AAA ATPase domain; Region: AAA_16; pfam13191 1133849017415 Predicted ATPase [General function prediction only]; Region: COG3903 1133849017416 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849017417 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849017418 DNA binding residues [nucleotide binding] 1133849017419 dimerization interface [polypeptide binding]; other site 1133849017420 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1133849017421 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1133849017422 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1133849017423 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1133849017424 homotetramer interface [polypeptide binding]; other site 1133849017425 FMN binding site [chemical binding]; other site 1133849017426 homodimer contacts [polypeptide binding]; other site 1133849017427 putative active site [active] 1133849017428 putative substrate binding site [chemical binding]; other site 1133849017429 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 1133849017430 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1133849017431 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 1133849017432 diphosphomevalonate decarboxylase; Region: PLN02407 1133849017433 diphosphomevalonate decarboxylase; Region: PLN02407 1133849017434 mevalonate kinase; Region: mevalon_kin; TIGR00549 1133849017435 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1133849017436 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1133849017437 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 1133849017438 dimer interface [polypeptide binding]; other site 1133849017439 active site 1133849017440 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 1133849017441 homodimer interface [polypeptide binding]; other site 1133849017442 substrate binding pocket [chemical binding]; other site 1133849017443 catalytic residues [active] 1133849017444 NADH/NADPH cofactor binding site [chemical binding]; other site 1133849017445 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1133849017446 active site 1133849017447 catalytic triad [active] 1133849017448 oxyanion hole [active] 1133849017449 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1133849017450 classical (c) SDRs; Region: SDR_c; cd05233 1133849017451 NAD(P) binding site [chemical binding]; other site 1133849017452 active site 1133849017453 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1133849017454 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1133849017455 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1133849017456 glutamine binding [chemical binding]; other site 1133849017457 catalytic triad [active] 1133849017458 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1133849017459 Isochorismatase family; Region: Isochorismatase; pfam00857 1133849017460 catalytic triad [active] 1133849017461 conserved cis-peptide bond; other site 1133849017462 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1133849017463 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849017464 NAD(P) binding site [chemical binding]; other site 1133849017465 active site 1133849017466 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1133849017467 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849017468 acyl-activating enzyme (AAE) consensus motif; other site 1133849017469 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849017470 acyl-activating enzyme (AAE) consensus motif; other site 1133849017471 AMP binding site [chemical binding]; other site 1133849017472 active site 1133849017473 CoA binding site [chemical binding]; other site 1133849017474 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; COG0382 1133849017475 UbiA prenyltransferase family; Region: UbiA; pfam01040 1133849017476 acyl-CoA synthetase; Validated; Region: PRK07788 1133849017477 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849017478 acyl-activating enzyme (AAE) consensus motif; other site 1133849017479 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849017480 active site 1133849017481 CoA binding site [chemical binding]; other site 1133849017482 AMP binding site [chemical binding]; other site 1133849017483 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1133849017484 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1133849017485 substrate binding pocket [chemical binding]; other site 1133849017486 chain length determination region; other site 1133849017487 substrate-Mg2+ binding site; other site 1133849017488 catalytic residues [active] 1133849017489 aspartate-rich region 1; other site 1133849017490 active site lid residues [active] 1133849017491 aspartate-rich region 2; other site 1133849017492 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1133849017493 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849017494 NAD(P) binding site [chemical binding]; other site 1133849017495 active site 1133849017496 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849017497 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849017498 active site 1133849017499 phosphorylation site [posttranslational modification] 1133849017500 intermolecular recognition site; other site 1133849017501 dimerization interface [polypeptide binding]; other site 1133849017502 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849017503 DNA binding residues [nucleotide binding] 1133849017504 dimerization interface [polypeptide binding]; other site 1133849017505 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1133849017506 Histidine kinase; Region: HisKA_3; pfam07730 1133849017507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849017508 ATP binding site [chemical binding]; other site 1133849017509 Mg2+ binding site [ion binding]; other site 1133849017510 G-X-G motif; other site 1133849017511 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1133849017512 DNA binding site [nucleotide binding] 1133849017513 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1133849017514 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1133849017515 DNA binding site [nucleotide binding] 1133849017516 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1133849017517 flavodoxin; Provisional; Region: PRK06242 1133849017518 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1133849017519 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1133849017520 tetramer interface [polypeptide binding]; other site 1133849017521 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1133849017522 active site 1133849017523 Mg2+/Mn2+ binding site [ion binding]; other site 1133849017524 citrate synthase; Provisional; Region: PRK14033 1133849017525 Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111 1133849017526 dimer interface [polypeptide binding]; other site 1133849017527 active site 1133849017528 citrylCoA binding site [chemical binding]; other site 1133849017529 oxalacetate/citrate binding site [chemical binding]; other site 1133849017530 coenzyme A binding site [chemical binding]; other site 1133849017531 catalytic triad [active] 1133849017532 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849017533 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849017534 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1133849017535 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1133849017536 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849017537 Walker A/P-loop; other site 1133849017538 ATP binding site [chemical binding]; other site 1133849017539 Q-loop/lid; other site 1133849017540 ABC transporter signature motif; other site 1133849017541 Walker B; other site 1133849017542 D-loop; other site 1133849017543 H-loop/switch region; other site 1133849017544 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1133849017545 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849017546 Walker A/P-loop; other site 1133849017547 ATP binding site [chemical binding]; other site 1133849017548 ABC transporter; Region: ABC_tran; pfam00005 1133849017549 Q-loop/lid; other site 1133849017550 ABC transporter signature motif; other site 1133849017551 Walker B; other site 1133849017552 D-loop; other site 1133849017553 H-loop/switch region; other site 1133849017554 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 1133849017555 Catalytic site [active] 1133849017556 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849017557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849017558 active site 1133849017559 phosphorylation site [posttranslational modification] 1133849017560 intermolecular recognition site; other site 1133849017561 dimerization interface [polypeptide binding]; other site 1133849017562 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849017563 dimerization interface [polypeptide binding]; other site 1133849017564 DNA binding residues [nucleotide binding] 1133849017565 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1133849017566 Histidine kinase; Region: HisKA_3; pfam07730 1133849017567 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1133849017568 active site 1133849017569 ATP binding site [chemical binding]; other site 1133849017570 substrate binding site [chemical binding]; other site 1133849017571 activation loop (A-loop); other site 1133849017572 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1133849017573 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 1133849017574 active site 1133849017575 zinc binding site [ion binding]; other site 1133849017576 Transmembrane secretion effector; Region: MFS_3; pfam05977 1133849017577 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1133849017578 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1133849017579 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849017580 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849017581 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cl17565 1133849017582 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849017583 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1133849017584 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1133849017585 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1133849017586 conserved cys residue [active] 1133849017587 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849017588 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1133849017589 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1133849017590 conserved cys residue [active] 1133849017591 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1133849017592 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1133849017593 hypothetical protein; Provisional; Region: PRK07758 1133849017594 Domain of unknown function (DUF4293); Region: DUF4293; pfam14126 1133849017595 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1133849017596 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849017597 NAD(P) binding site [chemical binding]; other site 1133849017598 active site 1133849017599 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849017600 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849017601 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 1133849017602 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1133849017603 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1133849017604 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1133849017605 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1133849017606 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1133849017607 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849017608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849017609 active site 1133849017610 phosphorylation site [posttranslational modification] 1133849017611 intermolecular recognition site; other site 1133849017612 dimerization interface [polypeptide binding]; other site 1133849017613 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849017614 DNA binding residues [nucleotide binding] 1133849017615 dimerization interface [polypeptide binding]; other site 1133849017616 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1133849017617 Histidine kinase; Region: HisKA_3; pfam07730 1133849017618 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1133849017619 ATP binding site [chemical binding]; other site 1133849017620 Mg2+ binding site [ion binding]; other site 1133849017621 G-X-G motif; other site 1133849017622 MMPL family; Region: MMPL; pfam03176 1133849017623 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1133849017624 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1133849017625 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 1133849017626 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 1133849017627 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 1133849017628 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1133849017629 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1133849017630 HTH domain; Region: HTH_11; pfam08279 1133849017631 Predicted transcriptional regulator [Transcription]; Region: COG2378 1133849017632 WYL domain; Region: WYL; pfam13280 1133849017633 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1133849017634 dimer interface [polypeptide binding]; other site 1133849017635 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849017636 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1133849017637 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1133849017638 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849017639 Helix-turn-helix domain; Region: HTH_18; pfam12833 1133849017640 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849017641 Protein of unknown function (DUF2000); Region: DUF2000; pfam09391 1133849017642 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1133849017643 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 1133849017644 enoyl-CoA hydratase; Provisional; Region: PRK08252 1133849017645 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1133849017646 substrate binding site [chemical binding]; other site 1133849017647 oxyanion hole (OAH) forming residues; other site 1133849017648 trimer interface [polypeptide binding]; other site 1133849017649 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1133849017650 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1133849017651 oligomer interface [polypeptide binding]; other site 1133849017652 putative Cl binding site [ion binding]; other site 1133849017653 basic sphincter; other site 1133849017654 hydrophobic gate; other site 1133849017655 periplasmic entrance; other site 1133849017656 AzlC protein; Region: AzlC; cl00570 1133849017657 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 1133849017658 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1133849017659 CGNR zinc finger; Region: zf-CGNR; pfam11706 1133849017660 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849017661 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849017662 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1133849017663 EthD domain; Region: EthD; cl17553 1133849017664 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1133849017665 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1133849017666 dimerization interface [polypeptide binding]; other site 1133849017667 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849017668 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849017669 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1133849017670 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1133849017671 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1133849017672 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1133849017673 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1133849017674 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1133849017675 dimerization interface [polypeptide binding]; other site 1133849017676 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1133849017677 dimer interface [polypeptide binding]; other site 1133849017678 phosphorylation site [posttranslational modification] 1133849017679 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849017680 ATP binding site [chemical binding]; other site 1133849017681 Mg2+ binding site [ion binding]; other site 1133849017682 G-X-G motif; other site 1133849017683 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1133849017684 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849017685 active site 1133849017686 phosphorylation site [posttranslational modification] 1133849017687 intermolecular recognition site; other site 1133849017688 dimerization interface [polypeptide binding]; other site 1133849017689 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1133849017690 DNA binding site [nucleotide binding] 1133849017691 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1133849017692 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1133849017693 substrate binding pocket [chemical binding]; other site 1133849017694 chain length determination region; other site 1133849017695 substrate-Mg2+ binding site; other site 1133849017696 catalytic residues [active] 1133849017697 aspartate-rich region 1; other site 1133849017698 active site lid residues [active] 1133849017699 aspartate-rich region 2; other site 1133849017700 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1133849017701 UbiA prenyltransferase family; Region: UbiA; pfam01040 1133849017702 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1133849017703 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1133849017704 active site 1133849017705 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 1133849017706 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1133849017707 NAD(P) binding site [chemical binding]; other site 1133849017708 Carboxylesterase family; Region: COesterase; pfam00135 1133849017709 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1133849017710 substrate binding pocket [chemical binding]; other site 1133849017711 catalytic triad [active] 1133849017712 acyltransferase PapA5; Provisional; Region: PRK09294 1133849017713 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 1133849017714 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1133849017715 NAD binding site [chemical binding]; other site 1133849017716 catalytic Zn binding site [ion binding]; other site 1133849017717 substrate binding site [chemical binding]; other site 1133849017718 structural Zn binding site [ion binding]; other site 1133849017719 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1133849017720 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849017721 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1133849017722 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1133849017723 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1133849017724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849017725 S-adenosylmethionine binding site [chemical binding]; other site 1133849017726 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1133849017727 catalytic residues [active] 1133849017728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849017729 H+ Antiporter protein; Region: 2A0121; TIGR00900 1133849017730 putative substrate translocation pore; other site 1133849017731 phosphoglucomutase; Validated; Region: PRK07564 1133849017732 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1133849017733 active site 1133849017734 substrate binding site [chemical binding]; other site 1133849017735 metal binding site [ion binding]; metal-binding site 1133849017736 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 1133849017737 Secretory lipase; Region: LIP; pfam03583 1133849017738 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1133849017739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849017740 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849017741 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849017742 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 1133849017743 FAD binding domain; Region: FAD_binding_4; pfam01565 1133849017744 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1133849017745 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1133849017746 NAD-dependent deacetylase; Provisional; Region: PRK00481 1133849017747 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1133849017748 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1133849017749 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1133849017750 active site 1133849017751 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849017752 Mitomycin C resistance protein (MRD); Region: MRD; cd07235 1133849017753 dimer interface [polypeptide binding]; other site 1133849017754 ligand binding site [chemical binding]; other site 1133849017755 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1133849017756 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1133849017757 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1133849017758 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1133849017759 threonine dehydratase; Provisional; Region: PRK08246 1133849017760 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849017761 catalytic residue [active] 1133849017762 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 1133849017763 putative catalytic residue [active] 1133849017764 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1133849017765 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849017766 putative substrate translocation pore; other site 1133849017767 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1133849017768 MarR family; Region: MarR; pfam01047 1133849017769 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 1133849017770 active site 1133849017771 catalytic triad [active] 1133849017772 oxyanion hole [active] 1133849017773 RibD C-terminal domain; Region: RibD_C; cl17279 1133849017774 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849017775 S-adenosylmethionine binding site [chemical binding]; other site 1133849017776 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1133849017777 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1133849017778 conserved cys residue [active] 1133849017779 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849017780 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849017781 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1133849017782 catalytic residues [active] 1133849017783 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 1133849017784 EamA-like transporter family; Region: EamA; pfam00892 1133849017785 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1133849017786 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849017787 non-specific DNA binding site [nucleotide binding]; other site 1133849017788 salt bridge; other site 1133849017789 sequence-specific DNA binding site [nucleotide binding]; other site 1133849017790 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1133849017791 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1133849017792 oligomer interface [polypeptide binding]; other site 1133849017793 active site residues [active] 1133849017794 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1133849017795 Clp protease; Region: CLP_protease; pfam00574 1133849017796 oligomer interface [polypeptide binding]; other site 1133849017797 active site residues [active] 1133849017798 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849017799 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849017800 active site 1133849017801 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849017802 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1133849017803 salt bridge; other site 1133849017804 non-specific DNA binding site [nucleotide binding]; other site 1133849017805 sequence-specific DNA binding site [nucleotide binding]; other site 1133849017806 short chain dehydrogenase; Provisional; Region: PRK12939 1133849017807 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849017808 NAD(P) binding site [chemical binding]; other site 1133849017809 active site 1133849017810 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1133849017811 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1133849017812 pyruvate dehydrogenase; Provisional; Region: PRK09124 1133849017813 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1133849017814 PYR/PP interface [polypeptide binding]; other site 1133849017815 tetramer interface [polypeptide binding]; other site 1133849017816 dimer interface [polypeptide binding]; other site 1133849017817 TPP binding site [chemical binding]; other site 1133849017818 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1133849017819 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1133849017820 TPP-binding site [chemical binding]; other site 1133849017821 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1133849017822 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1133849017823 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1133849017824 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1133849017825 putative metal binding site [ion binding]; other site 1133849017826 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1133849017827 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849017828 catalytic residue [active] 1133849017829 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 1133849017830 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849017831 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849017832 aspartate aminotransferase; Provisional; Region: PRK05764 1133849017833 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1133849017834 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849017835 homodimer interface [polypeptide binding]; other site 1133849017836 catalytic residue [active] 1133849017837 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 1133849017838 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1133849017839 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1133849017840 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1133849017841 putative dimerization interface [polypeptide binding]; other site 1133849017842 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1133849017843 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1133849017844 hypothetical protein; Provisional; Region: PRK07236 1133849017845 HTH domain; Region: HTH_11; pfam08279 1133849017846 WYL domain; Region: WYL; pfam13280 1133849017847 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1133849017848 Fic/DOC family; Region: Fic; cl00960 1133849017849 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1133849017850 AAA domain; Region: AAA_30; pfam13604 1133849017851 Family description; Region: UvrD_C_2; pfam13538 1133849017852 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1133849017853 SmpB-tmRNA interface; other site 1133849017854 Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain; Region: MPP_ACP5; cd07378 1133849017855 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1133849017856 active site 1133849017857 metal binding site [ion binding]; metal-binding site 1133849017858 alkaline phosphatase; Provisional; Region: PRK10518 1133849017859 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1133849017860 dimer interface [polypeptide binding]; other site 1133849017861 active site 1133849017862 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1133849017863 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1133849017864 ATP binding site [chemical binding]; other site 1133849017865 putative Mg++ binding site [ion binding]; other site 1133849017866 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1133849017867 nucleotide binding region [chemical binding]; other site 1133849017868 ATP-binding site [chemical binding]; other site 1133849017869 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1133849017870 HRDC domain; Region: HRDC; pfam00570 1133849017871 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1133849017872 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1133849017873 Coenzyme A binding pocket [chemical binding]; other site 1133849017874 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1133849017875 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1133849017876 active site 1133849017877 Predicted flavoprotein [General function prediction only]; Region: COG0431 1133849017878 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1133849017879 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1133849017880 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849017881 sequence-specific DNA binding site [nucleotide binding]; other site 1133849017882 salt bridge; other site 1133849017883 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1133849017884 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1133849017885 RF-1 domain; Region: RF-1; pfam00472 1133849017886 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1133849017887 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1133849017888 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849017889 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849017890 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1133849017891 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1133849017892 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1133849017893 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849017894 Walker A/P-loop; other site 1133849017895 ATP binding site [chemical binding]; other site 1133849017896 Q-loop/lid; other site 1133849017897 ABC transporter signature motif; other site 1133849017898 Walker B; other site 1133849017899 D-loop; other site 1133849017900 H-loop/switch region; other site 1133849017901 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1133849017902 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1133849017903 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1133849017904 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1133849017905 DNA binding residues [nucleotide binding] 1133849017906 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849017907 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1133849017908 PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750 1133849017909 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849017910 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849017911 active site 1133849017912 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849017913 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849017914 active site 1133849017915 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1133849017916 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849017917 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849017918 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849017919 dimerization interface [polypeptide binding]; other site 1133849017920 putative DNA binding site [nucleotide binding]; other site 1133849017921 putative Zn2+ binding site [ion binding]; other site 1133849017922 acyl-CoA synthetase; Validated; Region: PRK07788 1133849017923 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849017924 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1133849017925 acyl-activating enzyme (AAE) consensus motif; other site 1133849017926 putative AMP binding site [chemical binding]; other site 1133849017927 putative active site [active] 1133849017928 putative CoA binding site [chemical binding]; other site 1133849017929 acyl-CoA synthetase; Validated; Region: PRK07788 1133849017930 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849017931 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849017932 acyl-activating enzyme (AAE) consensus motif; other site 1133849017933 AMP binding site [chemical binding]; other site 1133849017934 active site 1133849017935 CoA binding site [chemical binding]; other site 1133849017936 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1133849017937 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1133849017938 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 1133849017939 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 1133849017940 Na binding site [ion binding]; other site 1133849017941 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1133849017942 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1133849017943 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC); Region: PvlArgDC; cl00849 1133849017944 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1133849017945 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1133849017946 metal binding site [ion binding]; metal-binding site 1133849017947 active site 1133849017948 I-site; other site 1133849017949 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849017950 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849017951 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 1133849017952 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1133849017953 Beta-lactamase; Region: Beta-lactamase; pfam00144 1133849017954 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1133849017955 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1133849017956 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 1133849017957 NAD binding site [chemical binding]; other site 1133849017958 substrate binding site [chemical binding]; other site 1133849017959 catalytic Zn binding site [ion binding]; other site 1133849017960 structural Zn binding site [ion binding]; other site 1133849017961 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1133849017962 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849017963 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849017964 acyl-activating enzyme (AAE) consensus motif; other site 1133849017965 acyl-activating enzyme (AAE) consensus motif; other site 1133849017966 AMP binding site [chemical binding]; other site 1133849017967 active site 1133849017968 CoA binding site [chemical binding]; other site 1133849017969 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849017970 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1133849017971 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1133849017972 anti sigma factor interaction site; other site 1133849017973 regulatory phosphorylation site [posttranslational modification]; other site 1133849017974 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1133849017975 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1133849017976 FcoT-like thioesterase domain; Region: FcoT; pfam10862 1133849017977 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1133849017978 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849017979 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1133849017980 acyl-activating enzyme (AAE) consensus motif; other site 1133849017981 acyl-activating enzyme (AAE) consensus motif; other site 1133849017982 putative AMP binding site [chemical binding]; other site 1133849017983 putative active site [active] 1133849017984 putative CoA binding site [chemical binding]; other site 1133849017985 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1133849017986 Condensation domain; Region: Condensation; pfam00668 1133849017987 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849017988 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1133849017989 acyl-activating enzyme (AAE) consensus motif; other site 1133849017990 AMP binding site [chemical binding]; other site 1133849017991 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849017992 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849017993 NAD(P) binding site [chemical binding]; other site 1133849017994 active site 1133849017995 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1133849017996 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1133849017997 intersubunit interface [polypeptide binding]; other site 1133849017998 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1133849017999 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1133849018000 dimer interface [polypeptide binding]; other site 1133849018001 ABC-ATPase subunit interface; other site 1133849018002 putative PBP binding regions; other site 1133849018003 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1133849018004 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1133849018005 Walker A/P-loop; other site 1133849018006 ATP binding site [chemical binding]; other site 1133849018007 Q-loop/lid; other site 1133849018008 ABC transporter signature motif; other site 1133849018009 Walker B; other site 1133849018010 D-loop; other site 1133849018011 H-loop/switch region; other site 1133849018012 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1133849018013 classical (c) SDRs; Region: SDR_c; cd05233 1133849018014 NAD(P) binding site [chemical binding]; other site 1133849018015 active site 1133849018016 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849018017 salt bridge; other site 1133849018018 non-specific DNA binding site [nucleotide binding]; other site 1133849018019 sequence-specific DNA binding site [nucleotide binding]; other site 1133849018020 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1133849018021 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1133849018022 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1133849018023 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849018024 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1133849018025 DNA binding residues [nucleotide binding] 1133849018026 Predicted integral membrane protein [Function unknown]; Region: COG5660 1133849018027 Putative zinc-finger; Region: zf-HC2; pfam13490 1133849018028 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1133849018029 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1133849018030 metal-binding site [ion binding] 1133849018031 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1133849018032 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1133849018033 Predicted membrane protein [Function unknown]; Region: COG3336 1133849018034 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1133849018035 classical (c) SDRs; Region: SDR_c; cd05233 1133849018036 NAD(P) binding site [chemical binding]; other site 1133849018037 active site 1133849018038 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1133849018039 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1133849018040 D-pathway; other site 1133849018041 Putative ubiquinol binding site [chemical binding]; other site 1133849018042 Low-spin heme (heme b) binding site [chemical binding]; other site 1133849018043 Putative water exit pathway; other site 1133849018044 Binuclear center (heme o3/CuB) [ion binding]; other site 1133849018045 K-pathway; other site 1133849018046 Putative proton exit pathway; other site 1133849018047 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1133849018048 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849018049 S-adenosylmethionine binding site [chemical binding]; other site 1133849018050 Predicted transcriptional regulators [Transcription]; Region: COG1695 1133849018051 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1133849018052 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1133849018053 active site 1133849018054 catalytic residues [active] 1133849018055 metal binding site [ion binding]; metal-binding site 1133849018056 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849018057 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1133849018058 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1133849018059 dimerization interface [polypeptide binding]; other site 1133849018060 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1133849018061 dimer interface [polypeptide binding]; other site 1133849018062 phosphorylation site [posttranslational modification] 1133849018063 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849018064 ATP binding site [chemical binding]; other site 1133849018065 Mg2+ binding site [ion binding]; other site 1133849018066 G-X-G motif; other site 1133849018067 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1133849018068 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1133849018069 DNA photolyase; Region: DNA_photolyase; pfam00875 1133849018070 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1133849018071 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1133849018072 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1133849018073 DNA binding residues [nucleotide binding] 1133849018074 B12 binding domain; Region: B12-binding_2; cl03653 1133849018075 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1133849018076 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1133849018077 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1133849018078 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 1133849018079 putative hydrophobic ligand binding site [chemical binding]; other site 1133849018080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849018081 TIGR01777 family protein; Region: yfcH 1133849018082 NAD(P) binding site [chemical binding]; other site 1133849018083 active site 1133849018084 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1133849018085 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1133849018086 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1133849018087 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1133849018088 Histidine kinase; Region: HisKA_3; pfam07730 1133849018089 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1133849018090 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849018091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849018092 active site 1133849018093 phosphorylation site [posttranslational modification] 1133849018094 intermolecular recognition site; other site 1133849018095 dimerization interface [polypeptide binding]; other site 1133849018096 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849018097 DNA binding residues [nucleotide binding] 1133849018098 dimerization interface [polypeptide binding]; other site 1133849018099 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1133849018100 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849018101 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1133849018102 benzoate transport; Region: 2A0115; TIGR00895 1133849018103 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849018104 putative substrate translocation pore; other site 1133849018105 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1133849018106 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1133849018107 NAD binding site [chemical binding]; other site 1133849018108 substrate binding site [chemical binding]; other site 1133849018109 putative active site [active] 1133849018110 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849018111 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 1133849018112 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849018113 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849018114 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1133849018115 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1133849018116 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 1133849018117 hypothetical protein; Validated; Region: PRK00068 1133849018118 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1133849018119 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1133849018120 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1133849018121 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 1133849018122 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1133849018123 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1133849018124 ABC1 family; Region: ABC1; pfam03109 1133849018125 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1133849018126 active site 1133849018127 ATP binding site [chemical binding]; other site 1133849018128 Subtilisin inhibitor-like; Region: SSI; cl11594 1133849018129 Cupin domain; Region: Cupin_2; pfam07883 1133849018130 Transcription factor WhiB; Region: Whib; pfam02467 1133849018131 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1133849018132 Part of AAA domain; Region: AAA_19; pfam13245 1133849018133 Family description; Region: UvrD_C_2; pfam13538 1133849018134 HRDC domain; Region: HRDC; pfam00570 1133849018135 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1133849018136 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1133849018137 catalytic residues [active] 1133849018138 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1133849018139 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1133849018140 putative NADH binding site [chemical binding]; other site 1133849018141 putative active site [active] 1133849018142 nudix motif; other site 1133849018143 putative metal binding site [ion binding]; other site 1133849018144 Ion channel; Region: Ion_trans_2; pfam07885 1133849018145 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1133849018146 TrkA-N domain; Region: TrkA_N; pfam02254 1133849018147 Predicted membrane protein [Function unknown]; Region: COG4270 1133849018148 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1133849018149 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1133849018150 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1133849018151 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1133849018152 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1133849018153 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1133849018154 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1133849018155 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1133849018156 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1133849018157 nucleophilic elbow; other site 1133849018158 catalytic site [active] 1133849018159 catalytic triad; other site 1133849018160 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1133849018161 DNA binding site [nucleotide binding] 1133849018162 active site 1133849018163 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1133849018164 active site 1133849018165 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1133849018166 active site 1133849018167 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1133849018168 GTP binding site; other site 1133849018169 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1133849018170 dimer interface [polypeptide binding]; other site 1133849018171 putative functional site; other site 1133849018172 putative MPT binding site; other site 1133849018173 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1133849018174 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 1133849018175 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1133849018176 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 1133849018177 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 1133849018178 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1133849018179 intersubunit interface [polypeptide binding]; other site 1133849018180 active site 1133849018181 Zn2+ binding site [ion binding]; other site 1133849018182 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1133849018183 Cupin domain; Region: Cupin_2; cl17218 1133849018184 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1133849018185 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1133849018186 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1133849018187 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1133849018188 molybdopterin cofactor binding site; other site 1133849018189 potential frameshift: common BLAST hit: gi|379710460|ref|YP_005265665.1| nitrate reductase subunit alpha 1133849018190 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1133849018191 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 1133849018192 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1133849018193 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 1133849018194 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1133849018195 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1133849018196 dimer interface [polypeptide binding]; other site 1133849018197 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 1133849018198 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849018199 non-specific DNA binding site [nucleotide binding]; other site 1133849018200 salt bridge; other site 1133849018201 sequence-specific DNA binding site [nucleotide binding]; other site 1133849018202 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 1133849018203 Cupin domain; Region: Cupin_2; pfam07883 1133849018204 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1133849018205 active site 1133849018206 metal binding site [ion binding]; metal-binding site 1133849018207 Protein of unknown function (DUF419); Region: DUF419; cl15265 1133849018208 Putative esterase; Region: Esterase; pfam00756 1133849018209 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849018210 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1133849018211 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849018212 acyl-activating enzyme (AAE) consensus motif; other site 1133849018213 AMP binding site [chemical binding]; other site 1133849018214 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849018215 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1133849018216 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1133849018217 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1133849018218 putative active site [active] 1133849018219 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1133849018220 putative active site [active] 1133849018221 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 1133849018222 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1133849018223 active site 1133849018224 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1133849018225 DNA binding site [nucleotide binding] 1133849018226 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1133849018227 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1133849018228 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1133849018229 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1133849018230 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1133849018231 cyanate transporter; Region: CynX; TIGR00896 1133849018232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849018233 putative substrate translocation pore; other site 1133849018234 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1133849018235 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1133849018236 DNA-binding site [nucleotide binding]; DNA binding site 1133849018237 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1133849018238 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 1133849018239 TIGR02569 family protein; Region: TIGR02569_actnb 1133849018240 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 1133849018241 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1133849018242 ATP binding site [chemical binding]; other site 1133849018243 substrate interface [chemical binding]; other site 1133849018244 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1133849018245 active site residue [active] 1133849018246 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1133849018247 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849018248 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849018249 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1133849018250 YceI-like domain; Region: YceI; pfam04264 1133849018251 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1133849018252 dinuclear metal binding motif [ion binding]; other site 1133849018253 Poly(3-hydroxyalkanoate) synthetase [Lipid metabolism]; Region: PhaC; COG3243 1133849018254 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1133849018255 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1133849018256 ATP binding site [chemical binding]; other site 1133849018257 Mg++ binding site [ion binding]; other site 1133849018258 motif III; other site 1133849018259 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1133849018260 nucleotide binding region [chemical binding]; other site 1133849018261 ATP-binding site [chemical binding]; other site 1133849018262 PQQ-like domain; Region: PQQ_2; pfam13360 1133849018263 Domain of unknown function (DUF385); Region: DUF385; cl04387 1133849018264 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1133849018265 catalytic core [active] 1133849018266 putative acetyltransferase; Provisional; Region: PRK03624 1133849018267 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1133849018268 Coenzyme A binding pocket [chemical binding]; other site 1133849018269 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1133849018270 Active_site [active] 1133849018271 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1133849018272 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1133849018273 Transcription factor WhiB; Region: Whib; pfam02467 1133849018274 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1133849018275 PAS domain S-box; Region: sensory_box; TIGR00229 1133849018276 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1133849018277 Histidine kinase; Region: HisKA_2; pfam07568 1133849018278 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849018279 ATP binding site [chemical binding]; other site 1133849018280 Mg2+ binding site [ion binding]; other site 1133849018281 G-X-G motif; other site 1133849018282 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1133849018283 carboxyltransferase (CT) interaction site; other site 1133849018284 biotinylation site [posttranslational modification]; other site 1133849018285 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 1133849018286 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1133849018287 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849018288 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1133849018289 DNA binding residues [nucleotide binding] 1133849018290 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1133849018291 putative deacylase active site [active] 1133849018292 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1133849018293 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1133849018294 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 1133849018295 NAD(P) binding site [chemical binding]; other site 1133849018296 catalytic residues [active] 1133849018297 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1133849018298 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1133849018299 hinge; other site 1133849018300 active site 1133849018301 Predicted GTPases [General function prediction only]; Region: COG1162 1133849018302 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1133849018303 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1133849018304 GTP/Mg2+ binding site [chemical binding]; other site 1133849018305 G4 box; other site 1133849018306 G5 box; other site 1133849018307 G1 box; other site 1133849018308 Switch I region; other site 1133849018309 G2 box; other site 1133849018310 G3 box; other site 1133849018311 Switch II region; other site 1133849018312 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1133849018313 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1133849018314 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1133849018315 nucleotide binding region [chemical binding]; other site 1133849018316 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1133849018317 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1133849018318 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1133849018319 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1133849018320 FAD binding pocket [chemical binding]; other site 1133849018321 FAD binding motif [chemical binding]; other site 1133849018322 phosphate binding motif [ion binding]; other site 1133849018323 beta-alpha-beta structure motif; other site 1133849018324 NAD binding pocket [chemical binding]; other site 1133849018325 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1133849018326 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1133849018327 catalytic loop [active] 1133849018328 iron binding site [ion binding]; other site 1133849018329 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1133849018330 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1133849018331 putative di-iron ligands [ion binding]; other site 1133849018332 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1133849018333 putative catalytic site [active] 1133849018334 putative metal binding site [ion binding]; other site 1133849018335 putative phosphate binding site [ion binding]; other site 1133849018336 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1133849018337 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1133849018338 putative di-iron ligands [ion binding]; other site 1133849018339 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1133849018340 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1133849018341 putative FMN binding site [chemical binding]; other site 1133849018342 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1133849018343 Coenzyme A binding pocket [chemical binding]; other site 1133849018344 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 1133849018345 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1133849018346 dimer interface [polypeptide binding]; other site 1133849018347 active site 1133849018348 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849018349 non-specific DNA binding site [nucleotide binding]; other site 1133849018350 salt bridge; other site 1133849018351 sequence-specific DNA binding site [nucleotide binding]; other site 1133849018352 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1133849018353 30S subunit binding site; other site 1133849018354 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1133849018355 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1133849018356 lipoprotein LpqB; Provisional; Region: PRK13616 1133849018357 Sporulation and spore germination; Region: Germane; pfam10646 1133849018358 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1133849018359 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1133849018360 dimerization interface [polypeptide binding]; other site 1133849018361 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1133849018362 dimer interface [polypeptide binding]; other site 1133849018363 phosphorylation site [posttranslational modification] 1133849018364 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849018365 ATP binding site [chemical binding]; other site 1133849018366 Mg2+ binding site [ion binding]; other site 1133849018367 G-X-G motif; other site 1133849018368 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1133849018369 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849018370 active site 1133849018371 phosphorylation site [posttranslational modification] 1133849018372 intermolecular recognition site; other site 1133849018373 dimerization interface [polypeptide binding]; other site 1133849018374 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1133849018375 DNA binding site [nucleotide binding] 1133849018376 thymidylate kinase; Validated; Region: PRK07933 1133849018377 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1133849018378 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1133849018379 homotetramer interface [polypeptide binding]; other site 1133849018380 ligand binding site [chemical binding]; other site 1133849018381 catalytic site [active] 1133849018382 NAD binding site [chemical binding]; other site 1133849018383 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 1133849018384 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1133849018385 active site 1133849018386 catalytic site [active] 1133849018387 metal binding site [ion binding]; metal-binding site 1133849018388 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 1133849018389 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1133849018390 Di-iron ligands [ion binding]; other site 1133849018391 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849018392 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849018393 Rubredoxin [Energy production and conversion]; Region: COG1773 1133849018394 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1133849018395 iron binding site [ion binding]; other site 1133849018396 Rubredoxin [Energy production and conversion]; Region: COG1773 1133849018397 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1133849018398 iron binding site [ion binding]; other site 1133849018399 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 1133849018400 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1133849018401 Di-iron ligands [ion binding]; other site 1133849018402 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 1133849018403 nudix motif; other site 1133849018404 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 1133849018405 F420-0:gamma-glutamyl ligase; Region: F420_cofE; TIGR01916 1133849018406 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 1133849018407 putative FMN binding site [chemical binding]; other site 1133849018408 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1133849018409 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 1133849018410 phosphate binding site [ion binding]; other site 1133849018411 dimer interface [polypeptide binding]; other site 1133849018412 substrate binding site [chemical binding]; other site 1133849018413 Transcription factor WhiB; Region: Whib; pfam02467 1133849018414 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1133849018415 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1133849018416 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1133849018417 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1133849018418 active site 1133849018419 substrate binding site [chemical binding]; other site 1133849018420 metal binding site [ion binding]; metal-binding site 1133849018421 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1133849018422 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1133849018423 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1133849018424 Cation efflux family; Region: Cation_efflux; pfam01545 1133849018425 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1133849018426 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849018427 WHG domain; Region: WHG; pfam13305 1133849018428 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 1133849018429 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 1133849018430 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1133849018431 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1133849018432 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1133849018433 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849018434 ATP binding site [chemical binding]; other site 1133849018435 Mg2+ binding site [ion binding]; other site 1133849018436 G-X-G motif; other site 1133849018437 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1133849018438 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849018439 active site 1133849018440 phosphorylation site [posttranslational modification] 1133849018441 intermolecular recognition site; other site 1133849018442 dimerization interface [polypeptide binding]; other site 1133849018443 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849018444 Cytochrome P450; Region: p450; cl12078 1133849018445 TIGR03089 family protein; Region: TIGR03089 1133849018446 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1133849018447 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1133849018448 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1133849018449 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1133849018450 NADP binding site [chemical binding]; other site 1133849018451 active site 1133849018452 putative substrate binding site [chemical binding]; other site 1133849018453 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1133849018454 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1133849018455 Probable Catalytic site; other site 1133849018456 metal-binding site 1133849018457 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1133849018458 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1133849018459 active site 1133849018460 Substrate binding site; other site 1133849018461 Mg++ binding site; other site 1133849018462 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1133849018463 N-terminal domain interface [polypeptide binding]; other site 1133849018464 sulfate 1 binding site; other site 1133849018465 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1133849018466 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1133849018467 substrate binding pocket [chemical binding]; other site 1133849018468 catalytic triad [active] 1133849018469 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 1133849018470 Rdx family; Region: Rdx; cl01407 1133849018471 hypothetical protein; Provisional; Region: PRK04233 1133849018472 SEC-C motif; Region: SEC-C; pfam02810 1133849018473 AAA domain; Region: AAA_23; pfam13476 1133849018474 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849018475 Walker A/P-loop; other site 1133849018476 ATP binding site [chemical binding]; other site 1133849018477 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849018478 ABC transporter signature motif; other site 1133849018479 Walker B; other site 1133849018480 D-loop; other site 1133849018481 H-loop/switch region; other site 1133849018482 SWIM zinc finger; Region: SWIM; pfam04434 1133849018483 MoxR-like ATPases [General function prediction only]; Region: COG0714 1133849018484 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1133849018485 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 1133849018486 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1133849018487 metal ion-dependent adhesion site (MIDAS); other site 1133849018488 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 1133849018489 active site 1133849018490 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1133849018491 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1133849018492 FtsX-like permease family; Region: FtsX; pfam02687 1133849018493 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1133849018494 FtsX-like permease family; Region: FtsX; pfam02687 1133849018495 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1133849018496 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1133849018497 Walker A/P-loop; other site 1133849018498 ATP binding site [chemical binding]; other site 1133849018499 Q-loop/lid; other site 1133849018500 ABC transporter signature motif; other site 1133849018501 Walker B; other site 1133849018502 D-loop; other site 1133849018503 H-loop/switch region; other site 1133849018504 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1133849018505 MarR family; Region: MarR_2; pfam12802 1133849018506 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1133849018507 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 1133849018508 putative ligand binding site [chemical binding]; other site 1133849018509 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 1133849018510 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 1133849018511 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1133849018512 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1133849018513 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849018514 catalytic residue [active] 1133849018515 elongation factor Tu; Reviewed; Region: PRK12736 1133849018516 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1133849018517 G1 box; other site 1133849018518 GEF interaction site [polypeptide binding]; other site 1133849018519 GTP/Mg2+ binding site [chemical binding]; other site 1133849018520 Switch I region; other site 1133849018521 G2 box; other site 1133849018522 G3 box; other site 1133849018523 Switch II region; other site 1133849018524 G4 box; other site 1133849018525 G5 box; other site 1133849018526 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1133849018527 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1133849018528 Antibiotic Binding Site [chemical binding]; other site 1133849018529 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1133849018530 active site 1133849018531 catalytic residues [active] 1133849018532 metal binding site [ion binding]; metal-binding site 1133849018533 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1133849018534 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1133849018535 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1133849018536 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1133849018537 endonuclease IV; Provisional; Region: PRK01060 1133849018538 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1133849018539 AP (apurinic/apyrimidinic) site pocket; other site 1133849018540 DNA interaction; other site 1133849018541 Metal-binding active site; metal-binding site 1133849018542 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1133849018543 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1133849018544 active site 1133849018545 ATP binding site [chemical binding]; other site 1133849018546 substrate binding site [chemical binding]; other site 1133849018547 activation loop (A-loop); other site 1133849018548 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1133849018549 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1133849018550 active site 1133849018551 ATP binding site [chemical binding]; other site 1133849018552 substrate binding site [chemical binding]; other site 1133849018553 activation loop (A-loop); other site 1133849018554 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1133849018555 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1133849018556 active site 1133849018557 ATP binding site [chemical binding]; other site 1133849018558 substrate binding site [chemical binding]; other site 1133849018559 activation loop (A-loop); other site 1133849018560 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1133849018561 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1133849018562 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1133849018563 active site 1133849018564 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1133849018565 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849018566 active site 1133849018567 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1133849018568 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849018569 HTH domain; Region: HTH_11; cl17392 1133849018570 WYL domain; Region: WYL; pfam13280 1133849018571 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1133849018572 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1133849018573 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849018574 EspG family; Region: ESX-1_EspG; pfam14011 1133849018575 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1133849018576 active site 1133849018577 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1133849018578 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1133849018579 putative active site [active] 1133849018580 catalytic triad [active] 1133849018581 putative dimer interface [polypeptide binding]; other site 1133849018582 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 1133849018583 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1133849018584 ATP binding site [chemical binding]; other site 1133849018585 Mg++ binding site [ion binding]; other site 1133849018586 motif III; other site 1133849018587 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1133849018588 nucleotide binding region [chemical binding]; other site 1133849018589 ATP-binding site [chemical binding]; other site 1133849018590 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1133849018591 putative RNA binding site [nucleotide binding]; other site 1133849018592 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1133849018593 Part of AAA domain; Region: AAA_19; pfam13245 1133849018594 AAA domain; Region: AAA_12; pfam13087 1133849018595 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 1133849018596 active site 1133849018597 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1133849018598 dimer interface [polypeptide binding]; other site 1133849018599 substrate binding site [chemical binding]; other site 1133849018600 catalytic residue [active] 1133849018601 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1133849018602 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1133849018603 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849018604 AMP-binding enzyme; Region: AMP-binding; pfam00501 1133849018605 acyl-activating enzyme (AAE) consensus motif; other site 1133849018606 active site 1133849018607 AMP binding site [chemical binding]; other site 1133849018608 CoA binding site [chemical binding]; other site 1133849018609 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1133849018610 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1133849018611 substrate binding site [chemical binding]; other site 1133849018612 oxyanion hole (OAH) forming residues; other site 1133849018613 trimer interface [polypeptide binding]; other site 1133849018614 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1133849018615 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1133849018616 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1133849018617 putative dimer interface [polypeptide binding]; other site 1133849018618 N-terminal domain interface [polypeptide binding]; other site 1133849018619 putative substrate binding pocket (H-site) [chemical binding]; other site 1133849018620 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1133849018621 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849018622 Walker A/P-loop; other site 1133849018623 ATP binding site [chemical binding]; other site 1133849018624 Q-loop/lid; other site 1133849018625 ABC transporter signature motif; other site 1133849018626 Walker B; other site 1133849018627 D-loop; other site 1133849018628 H-loop/switch region; other site 1133849018629 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1133849018630 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1133849018631 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849018632 Walker A/P-loop; other site 1133849018633 ATP binding site [chemical binding]; other site 1133849018634 Q-loop/lid; other site 1133849018635 ABC transporter signature motif; other site 1133849018636 Walker B; other site 1133849018637 D-loop; other site 1133849018638 H-loop/switch region; other site 1133849018639 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1133849018640 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1133849018641 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849018642 Walker A/P-loop; other site 1133849018643 ATP binding site [chemical binding]; other site 1133849018644 Q-loop/lid; other site 1133849018645 ABC transporter signature motif; other site 1133849018646 Walker B; other site 1133849018647 D-loop; other site 1133849018648 H-loop/switch region; other site 1133849018649 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1133849018650 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1133849018651 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1133849018652 TPP-binding site [chemical binding]; other site 1133849018653 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1133849018654 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1133849018655 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1133849018656 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1133849018657 catalytic core [active] 1133849018658 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1133849018659 homotrimer interaction site [polypeptide binding]; other site 1133849018660 putative active site [active] 1133849018661 Predicted transcriptional regulators [Transcription]; Region: COG1733 1133849018662 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1133849018663 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849018664 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849018665 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1133849018666 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1133849018667 short chain dehydrogenase; Provisional; Region: PRK07832 1133849018668 classical (c) SDRs; Region: SDR_c; cd05233 1133849018669 NAD(P) binding site [chemical binding]; other site 1133849018670 active site 1133849018671 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1133849018672 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1133849018673 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1133849018674 acyl-activating enzyme (AAE) consensus motif; other site 1133849018675 putative AMP binding site [chemical binding]; other site 1133849018676 putative active site [active] 1133849018677 putative CoA binding site [chemical binding]; other site 1133849018678 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1133849018679 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 1133849018680 Moco binding site; other site 1133849018681 metal coordination site [ion binding]; other site 1133849018682 dimerization interface [polypeptide binding]; other site 1133849018683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849018684 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1133849018685 putative substrate translocation pore; other site 1133849018686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849018687 Predicted transcriptional regulators [Transcription]; Region: COG1695 1133849018688 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1133849018689 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1133849018690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849018691 ABC-ATPase subunit interface; other site 1133849018692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1133849018693 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1133849018694 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1133849018695 Walker A/P-loop; other site 1133849018696 ATP binding site [chemical binding]; other site 1133849018697 Q-loop/lid; other site 1133849018698 ABC transporter signature motif; other site 1133849018699 Walker B; other site 1133849018700 D-loop; other site 1133849018701 H-loop/switch region; other site 1133849018702 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1133849018703 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1133849018704 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1133849018705 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1133849018706 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1133849018707 putative NAD(P) binding site [chemical binding]; other site 1133849018708 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1133849018709 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1133849018710 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1133849018711 active site 1133849018712 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1133849018713 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1133849018714 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1133849018715 oligomer interface [polypeptide binding]; other site 1133849018716 metal binding site [ion binding]; metal-binding site 1133849018717 metal binding site [ion binding]; metal-binding site 1133849018718 putative Cl binding site [ion binding]; other site 1133849018719 basic sphincter; other site 1133849018720 hydrophobic gate; other site 1133849018721 periplasmic entrance; other site 1133849018722 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1133849018723 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1133849018724 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1133849018725 PRC-barrel domain; Region: PRC; pfam05239 1133849018726 MgtE intracellular N domain; Region: MgtE_N; smart00924 1133849018727 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1133849018728 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 1133849018729 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1133849018730 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1133849018731 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1133849018732 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1133849018733 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1133849018734 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1133849018735 Domain of unknown function DUF59; Region: DUF59; pfam01883 1133849018736 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1133849018737 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1133849018738 DivIVA domain; Region: DivI1A_domain; TIGR03544 1133849018739 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1133849018740 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1133849018741 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1133849018742 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1133849018743 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1133849018744 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1133849018745 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1133849018746 ligand binding site; other site 1133849018747 oligomer interface; other site 1133849018748 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1133849018749 dimer interface [polypeptide binding]; other site 1133849018750 N-terminal domain interface [polypeptide binding]; other site 1133849018751 sulfate 1 binding site; other site 1133849018752 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1133849018753 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849018754 S-adenosylmethionine binding site [chemical binding]; other site 1133849018755 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 1133849018756 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849018757 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1133849018758 DNA binding residues [nucleotide binding] 1133849018759 Putative zinc-finger; Region: zf-HC2; pfam13490 1133849018760 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1133849018761 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1133849018762 protein binding site [polypeptide binding]; other site 1133849018763 sec-independent translocase; Provisional; Region: PRK03100 1133849018764 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1133849018765 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1133849018766 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1133849018767 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1133849018768 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1133849018769 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1133849018770 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1133849018771 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1133849018772 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1133849018773 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1133849018774 catalytic loop [active] 1133849018775 iron binding site [ion binding]; other site 1133849018776 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1133849018777 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 1133849018778 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1133849018779 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1133849018780 dihydropteroate synthase; Region: DHPS; TIGR01496 1133849018781 substrate binding pocket [chemical binding]; other site 1133849018782 dimer interface [polypeptide binding]; other site 1133849018783 inhibitor binding site; inhibition site 1133849018784 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 1133849018785 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1133849018786 acyl-activating enzyme (AAE) consensus motif; other site 1133849018787 putative AMP binding site [chemical binding]; other site 1133849018788 putative active site [active] 1133849018789 putative CoA binding site [chemical binding]; other site 1133849018790 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1133849018791 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1133849018792 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1133849018793 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1133849018794 metal binding site [ion binding]; metal-binding site 1133849018795 putative dimer interface [polypeptide binding]; other site 1133849018796 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1133849018797 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1133849018798 putative trimer interface [polypeptide binding]; other site 1133849018799 putative CoA binding site [chemical binding]; other site 1133849018800 acyl-CoA synthetase; Validated; Region: PRK07787 1133849018801 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849018802 acyl-activating enzyme (AAE) consensus motif; other site 1133849018803 AMP binding site [chemical binding]; other site 1133849018804 active site 1133849018805 CoA binding site [chemical binding]; other site 1133849018806 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1133849018807 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849018808 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849018809 heptad repeat 1-heptad repeat 2 region (ectodomain) of the transmembrane subunit of various endogenous retroviruses (ERVs) and infectious retroviruses, including Ebola virus and human immunodeficiency virus type 1 (HIV-1); Region: Ebola_HIV-1-like_HR1-HR2; cl02885 1133849018810 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1133849018811 Proline dehydrogenase; Region: Pro_dh; cl03282 1133849018812 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 1133849018813 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 1133849018814 Glutamate binding site [chemical binding]; other site 1133849018815 NAD binding site [chemical binding]; other site 1133849018816 catalytic residues [active] 1133849018817 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1133849018818 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1133849018819 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849018820 homodimer interface [polypeptide binding]; other site 1133849018821 catalytic residue [active] 1133849018822 Ferredoxin [Energy production and conversion]; Region: COG1146 1133849018823 4Fe-4S binding domain; Region: Fer4; pfam00037 1133849018824 FO synthase; Reviewed; Region: fbiC; PRK09234 1133849018825 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1133849018826 FeS/SAM binding site; other site 1133849018827 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1133849018828 FeS/SAM binding site; other site 1133849018829 Bacterial PH domain; Region: DUF304; cl01348 1133849018830 Bacterial PH domain; Region: DUF304; cl01348 1133849018831 Predicted membrane protein [Function unknown]; Region: COG3428 1133849018832 Bacterial PH domain; Region: DUF304; pfam03703 1133849018833 L-asparagine permease; Provisional; Region: PRK15049 1133849018834 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 1133849018835 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1133849018836 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1133849018837 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1133849018838 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1133849018839 G1 box; other site 1133849018840 putative GEF interaction site [polypeptide binding]; other site 1133849018841 GTP/Mg2+ binding site [chemical binding]; other site 1133849018842 Switch I region; other site 1133849018843 G2 box; other site 1133849018844 G3 box; other site 1133849018845 Switch II region; other site 1133849018846 G4 box; other site 1133849018847 G5 box; other site 1133849018848 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1133849018849 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1133849018850 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1133849018851 aromatic arch; other site 1133849018852 DCoH dimer interaction site [polypeptide binding]; other site 1133849018853 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1133849018854 DCoH tetramer interaction site [polypeptide binding]; other site 1133849018855 substrate binding site [chemical binding]; other site 1133849018856 mannosyltransferase; Provisional; Region: pimE; PRK13375 1133849018857 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 1133849018858 Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; cl01776 1133849018859 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 1133849018860 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1133849018861 putative active site [active] 1133849018862 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1133849018863 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1133849018864 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1133849018865 Walker A/P-loop; other site 1133849018866 ATP binding site [chemical binding]; other site 1133849018867 Q-loop/lid; other site 1133849018868 ABC transporter signature motif; other site 1133849018869 Walker B; other site 1133849018870 D-loop; other site 1133849018871 H-loop/switch region; other site 1133849018872 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849018873 ABC-ATPase subunit interface; other site 1133849018874 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1133849018875 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1133849018876 Predicted transcriptional regulator [Transcription]; Region: COG2378 1133849018877 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849018878 putative DNA binding site [nucleotide binding]; other site 1133849018879 putative Zn2+ binding site [ion binding]; other site 1133849018880 WYL domain; Region: WYL; pfam13280 1133849018881 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849018882 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1133849018883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849018884 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1133849018885 MarR family; Region: MarR; pfam01047 1133849018886 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1133849018887 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849018888 NAD(P) binding site [chemical binding]; other site 1133849018889 active site 1133849018890 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1133849018891 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1133849018892 EamA-like transporter family; Region: EamA; pfam00892 1133849018893 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1133849018894 EamA-like transporter family; Region: EamA; pfam00892 1133849018895 Secretory lipase; Region: LIP; pfam03583 1133849018896 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1133849018897 Predicted flavoprotein [General function prediction only]; Region: COG0431 1133849018898 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1133849018899 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1133849018900 NAD(P) binding site [chemical binding]; other site 1133849018901 catalytic residues [active] 1133849018902 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1133849018903 putative catalytic site [active] 1133849018904 putative phosphate binding site [ion binding]; other site 1133849018905 putative metal binding site [ion binding]; other site 1133849018906 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1133849018907 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1133849018908 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1133849018909 Beta-lactamase; Region: Beta-lactamase; pfam00144 1133849018910 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1133849018911 DinB superfamily; Region: DinB_2; pfam12867 1133849018912 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1133849018913 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1133849018914 Chorismate lyase; Region: Chor_lyase; cl01230 1133849018915 GTP-binding protein YchF; Reviewed; Region: PRK09601 1133849018916 YchF GTPase; Region: YchF; cd01900 1133849018917 G1 box; other site 1133849018918 GTP/Mg2+ binding site [chemical binding]; other site 1133849018919 Switch I region; other site 1133849018920 G2 box; other site 1133849018921 Switch II region; other site 1133849018922 G3 box; other site 1133849018923 G4 box; other site 1133849018924 G5 box; other site 1133849018925 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1133849018926 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1133849018927 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1133849018928 NAD(P) binding site [chemical binding]; other site 1133849018929 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1133849018930 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849018931 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849018932 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 1133849018933 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849018934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1133849018935 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1133849018936 Carbon starvation protein CstA; Region: CstA; pfam02554 1133849018937 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1133849018938 Protein of unknown function (DUF466); Region: DUF466; pfam04328 1133849018939 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1133849018940 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1133849018941 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1133849018942 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1133849018943 endonuclease III; Region: ENDO3c; smart00478 1133849018944 minor groove reading motif; other site 1133849018945 helix-hairpin-helix signature motif; other site 1133849018946 substrate binding pocket [chemical binding]; other site 1133849018947 active site 1133849018948 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1133849018949 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1133849018950 active site 1133849018951 DNA binding site [nucleotide binding] 1133849018952 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849018953 AAA domain; Region: AAA_23; pfam13476 1133849018954 Walker A/P-loop; other site 1133849018955 ATP binding site [chemical binding]; other site 1133849018956 Q-loop/lid; other site 1133849018957 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1133849018958 ABC transporter signature motif; other site 1133849018959 Walker B; other site 1133849018960 D-loop; other site 1133849018961 H-loop/switch region; other site 1133849018962 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1133849018963 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1133849018964 active site 1133849018965 metal binding site [ion binding]; metal-binding site 1133849018966 DNA binding site [nucleotide binding] 1133849018967 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1133849018968 RmuC family; Region: RmuC; pfam02646 1133849018969 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849018970 non-specific DNA binding site [nucleotide binding]; other site 1133849018971 sequence-specific DNA binding site [nucleotide binding]; other site 1133849018972 salt bridge; other site 1133849018973 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1133849018974 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1133849018975 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1133849018976 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1133849018977 generic binding surface II; other site 1133849018978 generic binding surface I; other site 1133849018979 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1133849018980 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1133849018981 active site 1133849018982 metal binding site [ion binding]; metal-binding site 1133849018983 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1133849018984 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1133849018985 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1133849018986 putative active site [active] 1133849018987 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1133849018988 Class II fumarases; Region: Fumarase_classII; cd01362 1133849018989 active site 1133849018990 tetramer interface [polypeptide binding]; other site 1133849018991 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1133849018992 dinuclear metal binding motif [ion binding]; other site 1133849018993 LGFP repeat; Region: LGFP; pfam08310 1133849018994 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1133849018995 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1133849018996 putative active site [active] 1133849018997 PhoH-like protein; Region: PhoH; pfam02562 1133849018998 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1133849018999 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 1133849019000 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849019001 Cytochrome P450; Region: p450; cl12078 1133849019002 Helix-turn-helix domain; Region: HTH_38; pfam13936 1133849019003 MarR family; Region: MarR_2; pfam12802 1133849019004 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1133849019005 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849019006 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849019007 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1133849019008 hypothetical protein; Provisional; Region: PRK07236 1133849019009 hypothetical protein; Provisional; Region: PRK07588 1133849019010 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1133849019011 EspG family; Region: ESX-1_EspG; pfam14011 1133849019012 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1133849019013 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1133849019014 dimer interface [polypeptide binding]; other site 1133849019015 active site 1133849019016 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1133849019017 folate binding site [chemical binding]; other site 1133849019018 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849019019 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849019020 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1133849019021 CoenzymeA binding site [chemical binding]; other site 1133849019022 subunit interaction site [polypeptide binding]; other site 1133849019023 PHB binding site; other site 1133849019024 Domain of unknown function (DUF385); Region: DUF385; cl04387 1133849019025 pantothenate kinase; Provisional; Region: PRK05439 1133849019026 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1133849019027 ATP-binding site [chemical binding]; other site 1133849019028 CoA-binding site [chemical binding]; other site 1133849019029 Mg2+-binding site [ion binding]; other site 1133849019030 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1133849019031 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1133849019032 catalytic residue [active] 1133849019033 putative FPP diphosphate binding site; other site 1133849019034 putative FPP binding hydrophobic cleft; other site 1133849019035 dimer interface [polypeptide binding]; other site 1133849019036 putative IPP diphosphate binding site; other site 1133849019037 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1133849019038 Haemolysin-III related; Region: HlyIII; cl03831 1133849019039 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1133849019040 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1133849019041 dimerization interface [polypeptide binding]; other site 1133849019042 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1133849019043 cyclase homology domain; Region: CHD; cd07302 1133849019044 nucleotidyl binding site; other site 1133849019045 metal binding site [ion binding]; metal-binding site 1133849019046 dimer interface [polypeptide binding]; other site 1133849019047 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1133849019048 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1133849019049 Fic family protein [Function unknown]; Region: COG3177 1133849019050 Fic/DOC family; Region: Fic; pfam02661 1133849019051 MarR family; Region: MarR; pfam01047 1133849019052 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1133849019053 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849019054 NAD(P) binding site [chemical binding]; other site 1133849019055 active site 1133849019056 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1133849019057 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1133849019058 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1133849019059 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1133849019060 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1133849019061 dimerization interface [polypeptide binding]; other site 1133849019062 substrate binding pocket [chemical binding]; other site 1133849019063 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1133849019064 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1133849019065 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1133849019066 TIGR03086 family protein; Region: TIGR03086 1133849019067 ribonuclease III; Reviewed; Region: rnc; PRK00102 1133849019068 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1133849019069 dimerization interface [polypeptide binding]; other site 1133849019070 active site 1133849019071 metal binding site [ion binding]; metal-binding site 1133849019072 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1133849019073 dsRNA binding site [nucleotide binding]; other site 1133849019074 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 1133849019075 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1133849019076 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1133849019077 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1133849019078 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1133849019079 cystathionine gamma-synthase; Provisional; Region: PRK07811 1133849019080 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1133849019081 homodimer interface [polypeptide binding]; other site 1133849019082 substrate-cofactor binding pocket; other site 1133849019083 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849019084 catalytic residue [active] 1133849019085 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849019086 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849019087 active site 1133849019088 Conserved TM helix; Region: TM_helix; pfam05552 1133849019089 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 1133849019090 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1133849019091 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1133849019092 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1133849019093 Na binding site [ion binding]; other site 1133849019094 Protein of unknown function DUF72; Region: DUF72; pfam01904 1133849019095 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 1133849019096 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1133849019097 dimer interface [polypeptide binding]; other site 1133849019098 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849019099 catalytic residue [active] 1133849019100 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1133849019101 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 1133849019102 active site 1133849019103 catalytic triad [active] 1133849019104 oxyanion hole [active] 1133849019105 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 1133849019106 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1133849019107 dimer interface [polypeptide binding]; other site 1133849019108 active site 1133849019109 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1133849019110 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 1133849019111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849019112 S-adenosylmethionine binding site [chemical binding]; other site 1133849019113 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1133849019114 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1133849019115 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1133849019116 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849019117 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1133849019118 catalytic site [active] 1133849019119 hypothetical protein; Provisional; Region: PRK06126 1133849019120 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1133849019121 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1133849019122 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1133849019123 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849019124 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1133849019125 short chain dehydrogenase; Provisional; Region: PRK06179 1133849019126 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1133849019127 NADP binding site [chemical binding]; other site 1133849019128 active site 1133849019129 steroid binding site; other site 1133849019130 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1133849019131 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1133849019132 dimerization interface [polypeptide binding]; other site 1133849019133 DPS ferroxidase diiron center [ion binding]; other site 1133849019134 ion pore; other site 1133849019135 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1133849019136 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1133849019137 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1133849019138 putative dimerization interface [polypeptide binding]; other site 1133849019139 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1133849019140 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1133849019141 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1133849019142 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1133849019143 putative dimerization interface [polypeptide binding]; other site 1133849019144 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1133849019145 NlpC/P60 family; Region: NLPC_P60; pfam00877 1133849019146 short chain dehydrogenase; Provisional; Region: PRK06181 1133849019147 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849019148 NAD(P) binding site [chemical binding]; other site 1133849019149 active site 1133849019150 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1133849019151 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1133849019152 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1133849019153 dimerization interface [polypeptide binding]; other site 1133849019154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849019155 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1133849019156 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1133849019157 O-methyltransferase; Region: Methyltransf_2; pfam00891 1133849019158 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1133849019159 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1133849019160 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1133849019161 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849019162 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1133849019163 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1133849019164 nucleotide binding site [chemical binding]; other site 1133849019165 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849019166 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849019167 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1133849019168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849019169 NAD(P) binding site [chemical binding]; other site 1133849019170 active site 1133849019171 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849019172 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849019173 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1133849019174 Lipase (class 2); Region: Lipase_2; pfam01674 1133849019175 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1133849019176 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849019177 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1133849019178 active site 1133849019179 phosphorylation site [posttranslational modification] 1133849019180 intermolecular recognition site; other site 1133849019181 dimerization interface [polypeptide binding]; other site 1133849019182 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849019183 DNA binding residues [nucleotide binding] 1133849019184 dimerization interface [polypeptide binding]; other site 1133849019185 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1133849019186 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1133849019187 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1133849019188 short chain dehydrogenase; Provisional; Region: PRK05872 1133849019189 classical (c) SDRs; Region: SDR_c; cd05233 1133849019190 NAD(P) binding site [chemical binding]; other site 1133849019191 active site 1133849019192 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1133849019193 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1133849019194 catalytic residue [active] 1133849019195 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1133849019196 DNA binding site [nucleotide binding] 1133849019197 Int/Topo IB signature motif; other site 1133849019198 active site 1133849019199 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 1133849019200 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1133849019201 Putative cyclase; Region: Cyclase; pfam04199 1133849019202 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1133849019203 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1133849019204 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1133849019205 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1133849019206 dimerization interface [polypeptide binding]; other site 1133849019207 substrate binding pocket [chemical binding]; other site 1133849019208 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1133849019209 DNA binding site [nucleotide binding] 1133849019210 active site 1133849019211 Int/Topo IB signature motif; other site 1133849019212 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1133849019213 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1133849019214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849019215 S-adenosylmethionine binding site [chemical binding]; other site 1133849019216 ribonuclease Z; Reviewed; Region: PRK00055 1133849019217 amino acid transporter; Region: 2A0306; TIGR00909 1133849019218 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1133849019219 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1133849019220 POT family; Region: PTR2; cl17359 1133849019221 POT family; Region: PTR2; cl17359 1133849019222 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1133849019223 hydrophobic ligand binding site; other site 1133849019224 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1133849019225 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1133849019226 Uncharacterized conserved protein [Function unknown]; Region: COG1507 1133849019227 Septum formation initiator; Region: DivIC; cl17659 1133849019228 enolase; Provisional; Region: eno; PRK00077 1133849019229 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1133849019230 dimer interface [polypeptide binding]; other site 1133849019231 metal binding site [ion binding]; metal-binding site 1133849019232 substrate binding pocket [chemical binding]; other site 1133849019233 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1133849019234 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1133849019235 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1133849019236 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1133849019237 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1133849019238 Walker A/P-loop; other site 1133849019239 ATP binding site [chemical binding]; other site 1133849019240 Q-loop/lid; other site 1133849019241 ABC transporter signature motif; other site 1133849019242 Walker B; other site 1133849019243 D-loop; other site 1133849019244 H-loop/switch region; other site 1133849019245 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1133849019246 ATP binding site [chemical binding]; other site 1133849019247 Q-loop/lid; other site 1133849019248 ABC transporter signature motif; other site 1133849019249 Walker B; other site 1133849019250 D-loop; other site 1133849019251 H-loop/switch region; other site 1133849019252 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1133849019253 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1133849019254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849019255 dimer interface [polypeptide binding]; other site 1133849019256 conserved gate region; other site 1133849019257 putative PBP binding loops; other site 1133849019258 ABC-ATPase subunit interface; other site 1133849019259 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 1133849019260 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1133849019261 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1133849019262 substrate binding pocket [chemical binding]; other site 1133849019263 active site 1133849019264 iron coordination sites [ion binding]; other site 1133849019265 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1133849019266 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1133849019267 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1133849019268 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1133849019269 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842 1133849019270 dimer interface [polypeptide binding]; other site 1133849019271 active site 1133849019272 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1133849019273 catalytic residues [active] 1133849019274 substrate binding site [chemical binding]; other site 1133849019275 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1133849019276 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1133849019277 dimer interface [polypeptide binding]; other site 1133849019278 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849019279 catalytic residue [active] 1133849019280 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1133849019281 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1133849019282 cation binding site [ion binding]; other site 1133849019283 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1133849019284 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1133849019285 putative metal binding site [ion binding]; other site 1133849019286 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1133849019287 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 1133849019288 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1133849019289 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1133849019290 active site 1133849019291 metal binding site [ion binding]; metal-binding site 1133849019292 hexamer interface [polypeptide binding]; other site 1133849019293 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1133849019294 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1133849019295 dimer interface [polypeptide binding]; other site 1133849019296 active site 1133849019297 metal binding site [ion binding]; metal-binding site 1133849019298 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 1133849019299 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1133849019300 homodimer interface [polypeptide binding]; other site 1133849019301 metal binding site [ion binding]; metal-binding site 1133849019302 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1133849019303 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1133849019304 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1133849019305 ATP binding site [chemical binding]; other site 1133849019306 putative Mg++ binding site [ion binding]; other site 1133849019307 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1133849019308 nucleotide binding region [chemical binding]; other site 1133849019309 ATP-binding site [chemical binding]; other site 1133849019310 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1133849019311 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849019312 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849019313 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849019314 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849019315 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1133849019316 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1133849019317 Substrate binding site; other site 1133849019318 Mg++ binding site; other site 1133849019319 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1133849019320 active site 1133849019321 substrate binding site [chemical binding]; other site 1133849019322 CoA binding site [chemical binding]; other site 1133849019323 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1133849019324 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1133849019325 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1133849019326 active site 1133849019327 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1133849019328 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 1133849019329 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 1133849019330 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1133849019331 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 1133849019332 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1133849019333 putative active site [active] 1133849019334 putative dimer interface [polypeptide binding]; other site 1133849019335 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1133849019336 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1133849019337 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1133849019338 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1133849019339 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1133849019340 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849019341 catalytic residue [active] 1133849019342 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849019343 WHG domain; Region: WHG; pfam13305 1133849019344 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1133849019345 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1133849019346 putative acyl-acceptor binding pocket; other site 1133849019347 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 1133849019348 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1133849019349 acyl-activating enzyme (AAE) consensus motif; other site 1133849019350 active site 1133849019351 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1133849019352 putative active site [active] 1133849019353 catalytic residue [active] 1133849019354 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 1133849019355 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1133849019356 5S rRNA interface [nucleotide binding]; other site 1133849019357 CTC domain interface [polypeptide binding]; other site 1133849019358 L16 interface [polypeptide binding]; other site 1133849019359 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 1133849019360 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1133849019361 G1 box; other site 1133849019362 putative GEF interaction site [polypeptide binding]; other site 1133849019363 GTP/Mg2+ binding site [chemical binding]; other site 1133849019364 Switch I region; other site 1133849019365 G2 box; other site 1133849019366 G3 box; other site 1133849019367 Switch II region; other site 1133849019368 G4 box; other site 1133849019369 G5 box; other site 1133849019370 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1133849019371 SnoaL-like domain; Region: SnoaL_4; pfam13577 1133849019372 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 1133849019373 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1133849019374 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 1133849019375 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1133849019376 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849019377 Walker A/P-loop; other site 1133849019378 ATP binding site [chemical binding]; other site 1133849019379 Q-loop/lid; other site 1133849019380 ABC transporter signature motif; other site 1133849019381 Walker B; other site 1133849019382 D-loop; other site 1133849019383 H-loop/switch region; other site 1133849019384 ABC transporter; Region: ABC_tran_2; pfam12848 1133849019385 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1133849019386 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1133849019387 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1133849019388 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1133849019389 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1133849019390 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1133849019391 metal-binding site [ion binding] 1133849019392 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1133849019393 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1133849019394 Secretory lipase; Region: LIP; pfam03583 1133849019395 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849019396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1133849019397 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1133849019398 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1133849019399 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1133849019400 G5 domain; Region: G5; pfam07501 1133849019401 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1133849019402 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1133849019403 active site 1133849019404 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1133849019405 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1133849019406 active site 1133849019407 HIGH motif; other site 1133849019408 KMSKS motif; other site 1133849019409 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1133849019410 tRNA binding surface [nucleotide binding]; other site 1133849019411 anticodon binding site; other site 1133849019412 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849019413 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849019414 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1133849019415 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1133849019416 tetramer interface [polypeptide binding]; other site 1133849019417 active site 1133849019418 Mg2+/Mn2+ binding site [ion binding]; other site 1133849019419 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1133849019420 Predicted methyltransferases [General function prediction only]; Region: COG0313 1133849019421 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1133849019422 putative SAM binding site [chemical binding]; other site 1133849019423 putative homodimer interface [polypeptide binding]; other site 1133849019424 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1133849019425 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1133849019426 DNA-binding site [nucleotide binding]; DNA binding site 1133849019427 arginine deiminase; Provisional; Region: PRK01388 1133849019428 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1133849019429 DNA binding residues [nucleotide binding] 1133849019430 short chain dehydrogenase; Provisional; Region: PRK07832 1133849019431 classical (c) SDRs; Region: SDR_c; cd05233 1133849019432 NAD(P) binding site [chemical binding]; other site 1133849019433 active site 1133849019434 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1133849019435 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1133849019436 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1133849019437 GAF domain; Region: GAF; pfam01590 1133849019438 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1133849019439 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1133849019440 metal binding site [ion binding]; metal-binding site 1133849019441 active site 1133849019442 I-site; other site 1133849019443 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1133849019444 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1133849019445 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1133849019446 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 1133849019447 Fe-S cluster binding site [ion binding]; other site 1133849019448 DNA binding site [nucleotide binding] 1133849019449 active site 1133849019450 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1133849019451 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1133849019452 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849019453 non-specific DNA binding site [nucleotide binding]; other site 1133849019454 salt bridge; other site 1133849019455 sequence-specific DNA binding site [nucleotide binding]; other site 1133849019456 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1133849019457 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1133849019458 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1133849019459 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1133849019460 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849019461 MarR family; Region: MarR; pfam01047 1133849019462 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1133849019463 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849019464 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849019465 Predicted acyl esterases [General function prediction only]; Region: COG2936 1133849019466 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1133849019467 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1133849019468 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1133849019469 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1133849019470 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1133849019471 SnoaL-like domain; Region: SnoaL_2; pfam12680 1133849019472 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849019473 Lipase (class 2); Region: Lipase_2; pfam01674 1133849019474 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849019475 K+ potassium transporter; Region: K_trans; cl15781 1133849019476 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1133849019477 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1133849019478 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1133849019479 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1133849019480 FMN binding site [chemical binding]; other site 1133849019481 active site 1133849019482 substrate binding site [chemical binding]; other site 1133849019483 catalytic residue [active] 1133849019484 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1133849019485 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 1133849019486 DNA binding residues [nucleotide binding] 1133849019487 putative dimer interface [polypeptide binding]; other site 1133849019488 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1133849019489 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1133849019490 Metal-binding active site; metal-binding site 1133849019491 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1133849019492 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1133849019493 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1133849019494 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1133849019495 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1133849019496 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1133849019497 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1133849019498 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1133849019499 TM-ABC transporter signature motif; other site 1133849019500 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1133849019501 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1133849019502 Walker A/P-loop; other site 1133849019503 ATP binding site [chemical binding]; other site 1133849019504 Q-loop/lid; other site 1133849019505 ABC transporter signature motif; other site 1133849019506 Walker B; other site 1133849019507 D-loop; other site 1133849019508 H-loop/switch region; other site 1133849019509 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1133849019510 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1133849019511 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1133849019512 nucleotide binding site [chemical binding]; other site 1133849019513 RibD C-terminal domain; Region: RibD_C; cl17279 1133849019514 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 1133849019515 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1133849019516 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1133849019517 DNA-binding site [nucleotide binding]; DNA binding site 1133849019518 RNA-binding motif; other site 1133849019519 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1133849019520 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1133849019521 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1133849019522 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1133849019523 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1133849019524 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1133849019525 MarR family; Region: MarR_2; cl17246 1133849019526 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1133849019527 metal ion-dependent adhesion site (MIDAS); other site 1133849019528 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1133849019529 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1133849019530 Walker A motif; other site 1133849019531 ATP binding site [chemical binding]; other site 1133849019532 Walker B motif; other site 1133849019533 arginine finger; other site 1133849019534 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849019535 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849019536 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1133849019537 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1133849019538 conserved cys residue [active] 1133849019539 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849019540 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1133849019541 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1133849019542 substrate binding pocket [chemical binding]; other site 1133849019543 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1133849019544 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849019545 SnoaL-like domain; Region: SnoaL_2; pfam12680 1133849019546 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1133849019547 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1133849019548 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849019549 homodimer interface [polypeptide binding]; other site 1133849019550 catalytic residue [active] 1133849019551 Cupin domain; Region: Cupin_2; cl17218 1133849019552 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1133849019553 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1133849019554 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1133849019555 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1133849019556 dimer interface [polypeptide binding]; other site 1133849019557 putative functional site; other site 1133849019558 putative MPT binding site; other site 1133849019559 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 1133849019560 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1133849019561 active site 1133849019562 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1133849019563 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1133849019564 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1133849019565 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1133849019566 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1133849019567 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1133849019568 MspA; Region: MspA; pfam09203 1133849019569 MspA; Region: MspA; pfam09203 1133849019570 MspA; Region: MspA; pfam09203 1133849019571 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1133849019572 MPT binding site; other site 1133849019573 trimer interface [polypeptide binding]; other site 1133849019574 serine endoprotease; Provisional; Region: PRK10898 1133849019575 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1133849019576 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1133849019577 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1133849019578 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1133849019579 dimerization interface [polypeptide binding]; other site 1133849019580 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1133849019581 dimer interface [polypeptide binding]; other site 1133849019582 phosphorylation site [posttranslational modification] 1133849019583 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849019584 ATP binding site [chemical binding]; other site 1133849019585 Mg2+ binding site [ion binding]; other site 1133849019586 G-X-G motif; other site 1133849019587 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1133849019588 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849019589 active site 1133849019590 phosphorylation site [posttranslational modification] 1133849019591 intermolecular recognition site; other site 1133849019592 dimerization interface [polypeptide binding]; other site 1133849019593 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1133849019594 DNA binding site [nucleotide binding] 1133849019595 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1133849019596 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849019597 ATP binding site [chemical binding]; other site 1133849019598 Mg2+ binding site [ion binding]; other site 1133849019599 G-X-G motif; other site 1133849019600 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 1133849019601 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1133849019602 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1133849019603 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1133849019604 G1 box; other site 1133849019605 GTP/Mg2+ binding site [chemical binding]; other site 1133849019606 G2 box; other site 1133849019607 Switch I region; other site 1133849019608 G3 box; other site 1133849019609 Switch II region; other site 1133849019610 G4 box; other site 1133849019611 G5 box; other site 1133849019612 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1133849019613 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 1133849019614 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1133849019615 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1133849019616 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1133849019617 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1133849019618 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1133849019619 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1133849019620 30S ribosomal protein S18; Provisional; Region: PRK13401 1133849019621 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1133849019622 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1133849019623 dimer interface [polypeptide binding]; other site 1133849019624 active site 1133849019625 CoA binding pocket [chemical binding]; other site 1133849019626 Pseudomonas avirulence D protein (AvrD); Region: AvrD; pfam05655 1133849019627 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1133849019628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849019629 putative substrate translocation pore; other site 1133849019630 AAA domain; Region: AAA_28; pfam13521 1133849019631 D-mannose binding lectin; Region: B_lectin; pfam01453 1133849019632 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 1133849019633 mannose binding site [chemical binding]; other site 1133849019634 dimerization interface [polypeptide binding]; other site 1133849019635 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1133849019636 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1133849019637 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 1133849019638 active site 1133849019639 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1133849019640 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1133849019641 purine monophosphate binding site [chemical binding]; other site 1133849019642 dimer interface [polypeptide binding]; other site 1133849019643 putative catalytic residues [active] 1133849019644 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1133849019645 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1133849019646 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1133849019647 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1133849019648 active site 1133849019649 substrate binding site [chemical binding]; other site 1133849019650 cosubstrate binding site; other site 1133849019651 catalytic site [active] 1133849019652 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1133849019653 AAA ATPase domain; Region: AAA_16; pfam13191 1133849019654 Predicted ATPase [General function prediction only]; Region: COG3903 1133849019655 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1133849019656 CoA binding domain; Region: CoA_binding; smart00881 1133849019657 CoA-ligase; Region: Ligase_CoA; pfam00549 1133849019658 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1133849019659 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1133849019660 CoA-ligase; Region: Ligase_CoA; pfam00549 1133849019661 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1133849019662 Peptidase family M23; Region: Peptidase_M23; pfam01551 1133849019663 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1133849019664 hydrophobic ligand binding site; other site 1133849019665 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1133849019666 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849019667 NAD(P) binding site [chemical binding]; other site 1133849019668 active site 1133849019669 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1133849019670 Part of AAA domain; Region: AAA_19; pfam13245 1133849019671 Family description; Region: UvrD_C_2; pfam13538 1133849019672 hypothetical protein; Provisional; Region: PRK07857 1133849019673 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1133849019674 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1133849019675 tetramerization interface [polypeptide binding]; other site 1133849019676 NAD(P) binding site [chemical binding]; other site 1133849019677 catalytic residues [active] 1133849019678 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1133849019679 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1133849019680 active site 1133849019681 dimer interface [polypeptide binding]; other site 1133849019682 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1133849019683 dimer interface [polypeptide binding]; other site 1133849019684 active site 1133849019685 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 1133849019686 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1133849019687 active site 1133849019688 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1133849019689 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1133849019690 active site 1133849019691 Zn binding site [ion binding]; other site 1133849019692 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1133849019693 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849019694 active site 1133849019695 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1133849019696 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1133849019697 substrate binding site [chemical binding]; other site 1133849019698 oxyanion hole (OAH) forming residues; other site 1133849019699 trimer interface [polypeptide binding]; other site 1133849019700 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1133849019701 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1133849019702 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1133849019703 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1133849019704 DNA-binding site [nucleotide binding]; DNA binding site 1133849019705 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1133849019706 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849019707 homodimer interface [polypeptide binding]; other site 1133849019708 catalytic residue [active] 1133849019709 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 1133849019710 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1133849019711 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1133849019712 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1133849019713 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1133849019714 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1133849019715 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1133849019716 substrate binding pocket [chemical binding]; other site 1133849019717 catalytic triad [active] 1133849019718 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1133849019719 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 1133849019720 putative DNA binding site [nucleotide binding]; other site 1133849019721 catalytic residue [active] 1133849019722 putative H2TH interface [polypeptide binding]; other site 1133849019723 putative catalytic residues [active] 1133849019724 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1133849019725 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1133849019726 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 1133849019727 active site 1133849019728 SAM binding site [chemical binding]; other site 1133849019729 homodimer interface [polypeptide binding]; other site 1133849019730 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1133849019731 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1133849019732 dimerization interface [polypeptide binding]; other site 1133849019733 active site 1133849019734 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1133849019735 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1133849019736 folate binding site [chemical binding]; other site 1133849019737 NADP+ binding site [chemical binding]; other site 1133849019738 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1133849019739 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1133849019740 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 1133849019741 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849019742 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849019743 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 1133849019744 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 1133849019745 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1133849019746 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 1133849019747 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1133849019748 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1133849019749 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1133849019750 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1133849019751 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849019752 HTH domain; Region: HTH_11; pfam08279 1133849019753 Predicted transcriptional regulator [Transcription]; Region: COG2378 1133849019754 WYL domain; Region: WYL; pfam13280 1133849019755 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1133849019756 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 1133849019757 putative NAD(P) binding site [chemical binding]; other site 1133849019758 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1133849019759 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849019760 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1133849019761 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1133849019762 MarR family; Region: MarR_2; pfam12802 1133849019763 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1133849019764 active site 1133849019765 catalytic triad [active] 1133849019766 oxyanion hole [active] 1133849019767 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1133849019768 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849019769 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1133849019770 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1133849019771 active site 1133849019772 dimer interface [polypeptide binding]; other site 1133849019773 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1133849019774 Ligand Binding Site [chemical binding]; other site 1133849019775 Molecular Tunnel; other site 1133849019776 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849019777 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1133849019778 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 1133849019779 putative catalytic residues [active] 1133849019780 Condensation domain; Region: Condensation; pfam00668 1133849019781 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849019782 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1133849019783 acyl-activating enzyme (AAE) consensus motif; other site 1133849019784 AMP binding site [chemical binding]; other site 1133849019785 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849019786 Condensation domain; Region: Condensation; pfam00668 1133849019787 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849019788 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849019789 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849019790 acyl-activating enzyme (AAE) consensus motif; other site 1133849019791 AMP binding site [chemical binding]; other site 1133849019792 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849019793 Condensation domain; Region: Condensation; pfam00668 1133849019794 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849019795 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849019796 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849019797 acyl-activating enzyme (AAE) consensus motif; other site 1133849019798 AMP binding site [chemical binding]; other site 1133849019799 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849019800 Condensation domain; Region: Condensation; pfam00668 1133849019801 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849019802 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849019803 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849019804 acyl-activating enzyme (AAE) consensus motif; other site 1133849019805 AMP binding site [chemical binding]; other site 1133849019806 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849019807 peptide synthase; Provisional; Region: PRK12467 1133849019808 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849019809 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849019810 acyl-activating enzyme (AAE) consensus motif; other site 1133849019811 AMP binding site [chemical binding]; other site 1133849019812 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849019813 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849019814 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849019815 acyl-activating enzyme (AAE) consensus motif; other site 1133849019816 AMP binding site [chemical binding]; other site 1133849019817 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849019818 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1133849019819 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849019820 acyl-activating enzyme (AAE) consensus motif; other site 1133849019821 AMP binding site [chemical binding]; other site 1133849019822 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849019823 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849019824 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849019825 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849019826 acyl-activating enzyme (AAE) consensus motif; other site 1133849019827 AMP binding site [chemical binding]; other site 1133849019828 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1133849019829 Condensation domain; Region: Condensation; pfam00668 1133849019830 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849019831 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849019832 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849019833 acyl-activating enzyme (AAE) consensus motif; other site 1133849019834 AMP binding site [chemical binding]; other site 1133849019835 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849019836 Condensation domain; Region: Condensation; pfam00668 1133849019837 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849019838 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849019839 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849019840 acyl-activating enzyme (AAE) consensus motif; other site 1133849019841 AMP binding site [chemical binding]; other site 1133849019842 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849019843 Condensation domain; Region: Condensation; pfam00668 1133849019844 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849019845 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849019846 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849019847 acyl-activating enzyme (AAE) consensus motif; other site 1133849019848 AMP binding site [chemical binding]; other site 1133849019849 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849019850 Condensation domain; Region: Condensation; pfam00668 1133849019851 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849019852 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1133849019853 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1133849019854 acyl-activating enzyme (AAE) consensus motif; other site 1133849019855 AMP binding site [chemical binding]; other site 1133849019856 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849019857 Condensation domain; Region: Condensation; pfam00668 1133849019858 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1133849019859 Condensation domain; Region: Condensation; pfam00668 1133849019860 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1133849019861 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849019862 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1133849019863 active site 1133849019864 SAM binding site [chemical binding]; other site 1133849019865 homodimer interface [polypeptide binding]; other site 1133849019866 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1133849019867 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849019868 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849019869 active site 1133849019870 phosphorylation site [posttranslational modification] 1133849019871 intermolecular recognition site; other site 1133849019872 dimerization interface [polypeptide binding]; other site 1133849019873 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849019874 DNA binding residues [nucleotide binding] 1133849019875 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1133849019876 Histidine kinase; Region: HisKA_3; pfam07730 1133849019877 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1133849019878 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1133849019879 FtsX-like permease family; Region: FtsX; pfam02687 1133849019880 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1133849019881 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1133849019882 Walker A/P-loop; other site 1133849019883 ATP binding site [chemical binding]; other site 1133849019884 Q-loop/lid; other site 1133849019885 ABC transporter signature motif; other site 1133849019886 Walker B; other site 1133849019887 D-loop; other site 1133849019888 H-loop/switch region; other site 1133849019889 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1133849019890 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1133849019891 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1133849019892 dimerization interface [polypeptide binding]; other site 1133849019893 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849019894 metabolite-proton symporter; Region: 2A0106; TIGR00883 1133849019895 putative substrate translocation pore; other site 1133849019896 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1133849019897 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849019898 NAD(P) binding site [chemical binding]; other site 1133849019899 active site 1133849019900 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849019901 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849019902 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1133849019903 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1133849019904 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1133849019905 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1133849019906 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1133849019907 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1133849019908 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1133849019909 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1133849019910 carboxyltransferase (CT) interaction site; other site 1133849019911 biotinylation site [posttranslational modification]; other site 1133849019912 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849019913 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849019914 active site 1133849019915 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1133849019916 putative active site [active] 1133849019917 putative catalytic site [active] 1133849019918 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1133849019919 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 1133849019920 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849019921 acyl-activating enzyme (AAE) consensus motif; other site 1133849019922 AMP binding site [chemical binding]; other site 1133849019923 active site 1133849019924 CoA binding site [chemical binding]; other site 1133849019925 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849019926 Cytochrome P450; Region: p450; cl12078 1133849019927 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849019928 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849019929 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849019930 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849019931 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849019932 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849019933 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1133849019934 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1133849019935 mce related protein; Region: MCE; pfam02470 1133849019936 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1133849019937 mce related protein; Region: MCE; pfam02470 1133849019938 mce related protein; Region: MCE; pfam02470 1133849019939 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1133849019940 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1133849019941 mce related protein; Region: MCE; pfam02470 1133849019942 Sucrose synthase; Region: Sucrose_synth; pfam00862 1133849019943 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1133849019944 mce related protein; Region: MCE; pfam02470 1133849019945 mce related protein; Region: MCE; pfam02470 1133849019946 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1133849019947 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1133849019948 Permease; Region: Permease; pfam02405 1133849019949 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1133849019950 Permease; Region: Permease; pfam02405 1133849019951 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1133849019952 Beta-lactamase; Region: Beta-lactamase; pfam00144 1133849019953 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1133849019954 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1133849019955 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1133849019956 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1133849019957 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1133849019958 potential catalytic triad [active] 1133849019959 conserved cys residue [active] 1133849019960 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1133849019961 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1133849019962 active site 1133849019963 catalytic tetrad [active] 1133849019964 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849019965 non-specific DNA binding site [nucleotide binding]; other site 1133849019966 salt bridge; other site 1133849019967 sequence-specific DNA binding site [nucleotide binding]; other site 1133849019968 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1133849019969 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 1133849019970 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1133849019971 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1133849019972 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 1133849019973 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1133849019974 active site 1133849019975 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 1133849019976 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 1133849019977 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1133849019978 FeS/SAM binding site; other site 1133849019979 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1133849019980 mycofactocin precursor; Region: mycofactocin; TIGR03969 1133849019981 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1133849019982 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849019983 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1133849019984 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1133849019985 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1133849019986 FAD binding pocket [chemical binding]; other site 1133849019987 FAD binding motif [chemical binding]; other site 1133849019988 phosphate binding motif [ion binding]; other site 1133849019989 NAD(p) ribose binding residues [chemical binding]; other site 1133849019990 beta-alpha-beta structure motif; other site 1133849019991 NAD binding pocket [chemical binding]; other site 1133849019992 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1133849019993 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1133849019994 catalytic loop [active] 1133849019995 iron binding site [ion binding]; other site 1133849019996 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1133849019997 A new structural DNA glycosylase; Region: AlkD_like; cd06561 1133849019998 active site 1133849019999 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1133849020000 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1133849020001 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1133849020002 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849020003 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849020004 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1133849020005 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849020006 TAP-like protein; Region: Abhydrolase_4; pfam08386 1133849020007 short chain dehydrogenase; Provisional; Region: PRK06523 1133849020008 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849020009 NAD(P) binding site [chemical binding]; other site 1133849020010 active site 1133849020011 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 1133849020012 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1133849020013 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 1133849020014 putative active site [active] 1133849020015 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 1133849020016 Protein of unknown function (DUF433); Region: DUF433; pfam04255 1133849020017 elongation factor Tu; Reviewed; Region: PRK00049 1133849020018 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1133849020019 G1 box; other site 1133849020020 GEF interaction site [polypeptide binding]; other site 1133849020021 GTP/Mg2+ binding site [chemical binding]; other site 1133849020022 Switch I region; other site 1133849020023 G2 box; other site 1133849020024 G3 box; other site 1133849020025 Switch II region; other site 1133849020026 G4 box; other site 1133849020027 G5 box; other site 1133849020028 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1133849020029 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1133849020030 Antibiotic Binding Site [chemical binding]; other site 1133849020031 elongation factor G; Reviewed; Region: PRK00007 1133849020032 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1133849020033 G1 box; other site 1133849020034 putative GEF interaction site [polypeptide binding]; other site 1133849020035 GTP/Mg2+ binding site [chemical binding]; other site 1133849020036 Switch I region; other site 1133849020037 G2 box; other site 1133849020038 G3 box; other site 1133849020039 Switch II region; other site 1133849020040 G4 box; other site 1133849020041 G5 box; other site 1133849020042 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1133849020043 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1133849020044 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1133849020045 30S ribosomal protein S7; Validated; Region: PRK05302 1133849020046 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1133849020047 S17 interaction site [polypeptide binding]; other site 1133849020048 S8 interaction site; other site 1133849020049 16S rRNA interaction site [nucleotide binding]; other site 1133849020050 streptomycin interaction site [chemical binding]; other site 1133849020051 23S rRNA interaction site [nucleotide binding]; other site 1133849020052 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1133849020053 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1133849020054 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1133849020055 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 1133849020056 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1133849020057 dimer interface [polypeptide binding]; other site 1133849020058 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1133849020059 active site 1133849020060 Fe binding site [ion binding]; other site 1133849020061 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1133849020062 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849020063 putative DNA binding site [nucleotide binding]; other site 1133849020064 putative Zn2+ binding site [ion binding]; other site 1133849020065 AsnC family; Region: AsnC_trans_reg; pfam01037 1133849020066 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1133849020067 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1133849020068 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1133849020069 NAD(P) binding site [chemical binding]; other site 1133849020070 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1133849020071 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1133849020072 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1133849020073 catalytic residue [active] 1133849020074 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1133849020075 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1133849020076 active site 1133849020077 ATP binding site [chemical binding]; other site 1133849020078 substrate binding site [chemical binding]; other site 1133849020079 activation loop (A-loop); other site 1133849020080 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1133849020081 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1133849020082 active site 1133849020083 ATP binding site [chemical binding]; other site 1133849020084 substrate binding site [chemical binding]; other site 1133849020085 activation loop (A-loop); other site 1133849020086 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1133849020087 active site 1133849020088 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1133849020089 active site 2 [active] 1133849020090 Ferredoxin [Energy production and conversion]; Region: COG1146 1133849020091 4Fe-4S binding domain; Region: Fer4; pfam00037 1133849020092 ferredoxin-NADP+ reductase; Region: PLN02852 1133849020093 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1133849020094 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1133849020095 catalytic core [active] 1133849020096 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849020097 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1133849020098 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1133849020099 putative active site [active] 1133849020100 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1133849020101 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1133849020102 DNA binding residues [nucleotide binding] 1133849020103 putative dimer interface [polypeptide binding]; other site 1133849020104 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1133849020105 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1133849020106 active site 1133849020107 catalytic tetrad [active] 1133849020108 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1133849020109 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1133849020110 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1133849020111 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1133849020112 Pirin-related protein [General function prediction only]; Region: COG1741 1133849020113 Pirin; Region: Pirin; pfam02678 1133849020114 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1133849020115 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1133849020116 active site 1133849020117 metal binding site [ion binding]; metal-binding site 1133849020118 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1133849020119 MarR family; Region: MarR_2; pfam12802 1133849020120 Helix-turn-helix domain; Region: HTH_31; pfam13560 1133849020121 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1133849020122 active site 1133849020123 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1133849020124 catalytic tetrad [active] 1133849020125 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1133849020126 CoenzymeA binding site [chemical binding]; other site 1133849020127 subunit interaction site [polypeptide binding]; other site 1133849020128 PHB binding site; other site 1133849020129 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1133849020130 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1133849020131 active site 1133849020132 catalytic site [active] 1133849020133 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1133849020134 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1133849020135 NAD(P) binding site [chemical binding]; other site 1133849020136 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1133849020137 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1133849020138 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1133849020139 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1133849020140 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1133849020141 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1133849020142 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1133849020143 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1133849020144 G-loop; other site 1133849020145 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1133849020146 DNA binding site [nucleotide binding] 1133849020147 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1133849020148 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1133849020149 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1133849020150 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1133849020151 RPB1 interaction site [polypeptide binding]; other site 1133849020152 RPB10 interaction site [polypeptide binding]; other site 1133849020153 RPB11 interaction site [polypeptide binding]; other site 1133849020154 RPB3 interaction site [polypeptide binding]; other site 1133849020155 RPB12 interaction site [polypeptide binding]; other site 1133849020156 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1133849020157 mce related protein; Region: MCE; pfam02470 1133849020158 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1133849020159 mce related protein; Region: MCE; pfam02470 1133849020160 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1133849020161 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1133849020162 mce related protein; Region: MCE; pfam02470 1133849020163 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1133849020164 mce related protein; Region: MCE; pfam02470 1133849020165 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1133849020166 mce related protein; Region: MCE; pfam02470 1133849020167 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1133849020168 mce related protein; Region: MCE; pfam02470 1133849020169 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1133849020170 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1133849020171 Permease; Region: Permease; pfam02405 1133849020172 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1133849020173 Permease; Region: Permease; pfam02405 1133849020174 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1133849020175 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1133849020176 Walker A/P-loop; other site 1133849020177 ATP binding site [chemical binding]; other site 1133849020178 Q-loop/lid; other site 1133849020179 ABC transporter signature motif; other site 1133849020180 Walker B; other site 1133849020181 D-loop; other site 1133849020182 H-loop/switch region; other site 1133849020183 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1133849020184 core dimer interface [polypeptide binding]; other site 1133849020185 peripheral dimer interface [polypeptide binding]; other site 1133849020186 L10 interface [polypeptide binding]; other site 1133849020187 L11 interface [polypeptide binding]; other site 1133849020188 putative EF-Tu interaction site [polypeptide binding]; other site 1133849020189 putative EF-G interaction site [polypeptide binding]; other site 1133849020190 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1133849020191 23S rRNA interface [nucleotide binding]; other site 1133849020192 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1133849020193 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849020194 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1133849020195 putative substrate translocation pore; other site 1133849020196 Predicted flavoprotein [General function prediction only]; Region: COG0431 1133849020197 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1133849020198 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1133849020199 mRNA/rRNA interface [nucleotide binding]; other site 1133849020200 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1133849020201 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1133849020202 23S rRNA interface [nucleotide binding]; other site 1133849020203 L7/L12 interface [polypeptide binding]; other site 1133849020204 putative thiostrepton binding site; other site 1133849020205 L25 interface [polypeptide binding]; other site 1133849020206 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1133849020207 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1133849020208 putative homodimer interface [polypeptide binding]; other site 1133849020209 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1133849020210 heterodimer interface [polypeptide binding]; other site 1133849020211 homodimer interface [polypeptide binding]; other site 1133849020212 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1133849020213 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1133849020214 active site 1133849020215 catalytic site [active] 1133849020216 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1133849020217 active site 1133849020218 catalytic site [active] 1133849020219 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1133849020220 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1133849020221 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1133849020222 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1133849020223 MarR family; Region: MarR_2; pfam12802 1133849020224 heat shock protein HtpX; Provisional; Region: PRK03072 1133849020225 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1133849020226 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1133849020227 substrate binding pocket [chemical binding]; other site 1133849020228 chain length determination region; other site 1133849020229 substrate-Mg2+ binding site; other site 1133849020230 catalytic residues [active] 1133849020231 aspartate-rich region 1; other site 1133849020232 active site lid residues [active] 1133849020233 aspartate-rich region 2; other site 1133849020234 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1133849020235 Helix-turn-helix domain; Region: HTH_18; pfam12833 1133849020236 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849020237 Predicted transcriptional regulators [Transcription]; Region: COG1695 1133849020238 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1133849020239 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1133849020240 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849020241 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1133849020242 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1133849020243 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1133849020244 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1133849020245 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849020246 S-adenosylmethionine binding site [chemical binding]; other site 1133849020247 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1133849020248 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1133849020249 molybdopterin cofactor binding site; other site 1133849020250 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1133849020251 molybdopterin cofactor binding site; other site 1133849020252 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 1133849020253 Flavodoxin; Region: Flavodoxin_1; pfam00258 1133849020254 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1133849020255 FAD binding pocket [chemical binding]; other site 1133849020256 FAD binding motif [chemical binding]; other site 1133849020257 catalytic residues [active] 1133849020258 NAD binding pocket [chemical binding]; other site 1133849020259 phosphate binding motif [ion binding]; other site 1133849020260 beta-alpha-beta structure motif; other site 1133849020261 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1133849020262 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1133849020263 active site 1133849020264 catalytic tetrad [active] 1133849020265 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1133849020266 TIGR03086 family protein; Region: TIGR03086 1133849020267 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1133849020268 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1133849020269 dimer interface [polypeptide binding]; other site 1133849020270 tetramer interface [polypeptide binding]; other site 1133849020271 PYR/PP interface [polypeptide binding]; other site 1133849020272 TPP binding site [chemical binding]; other site 1133849020273 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1133849020274 TPP-binding site; other site 1133849020275 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1133849020276 CoenzymeA binding site [chemical binding]; other site 1133849020277 subunit interaction site [polypeptide binding]; other site 1133849020278 PHB binding site; other site 1133849020279 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1133849020280 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1133849020281 substrate binding site [chemical binding]; other site 1133849020282 oxyanion hole (OAH) forming residues; other site 1133849020283 trimer interface [polypeptide binding]; other site 1133849020284 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849020285 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1133849020286 active site 1133849020287 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849020288 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 1133849020289 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849020290 acyl-activating enzyme (AAE) consensus motif; other site 1133849020291 acyl-activating enzyme (AAE) consensus motif; other site 1133849020292 AMP binding site [chemical binding]; other site 1133849020293 active site 1133849020294 CoA binding site [chemical binding]; other site 1133849020295 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849020296 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1133849020297 Walker A/P-loop; other site 1133849020298 ATP binding site [chemical binding]; other site 1133849020299 Q-loop/lid; other site 1133849020300 ABC transporter signature motif; other site 1133849020301 Walker B; other site 1133849020302 D-loop; other site 1133849020303 H-loop/switch region; other site 1133849020304 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1133849020305 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1133849020306 Bacterial transcriptional activator domain; Region: BTAD; smart01043 1133849020307 Predicted ATPase [General function prediction only]; Region: COG3903 1133849020308 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 1133849020309 putative hydrophobic ligand binding site [chemical binding]; other site 1133849020310 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1133849020311 UbiA prenyltransferase family; Region: UbiA; pfam01040 1133849020312 Predicted membrane protein [Function unknown]; Region: COG1950 1133849020313 Clp amino terminal domain; Region: Clp_N; pfam02861 1133849020314 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1133849020315 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1133849020316 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1133849020317 catalytic residue [active] 1133849020318 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 1133849020319 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1133849020320 DNA binding residues [nucleotide binding] 1133849020321 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1133849020322 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1133849020323 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1133849020324 ResB-like family; Region: ResB; pfam05140 1133849020325 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1133849020326 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1133849020327 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1133849020328 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1133849020329 catalytic residues [active] 1133849020330 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1133849020331 catalytic core [active] 1133849020332 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1133849020333 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1133849020334 inhibitor-cofactor binding pocket; inhibition site 1133849020335 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849020336 catalytic residue [active] 1133849020337 delta-aminolevulinic acid dehydratase; Validated; Region: PRK09283 1133849020338 dimer interface [polypeptide binding]; other site 1133849020339 active site 1133849020340 Schiff base residues; other site 1133849020341 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1133849020342 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1133849020343 TPR motif; other site 1133849020344 binding surface 1133849020345 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1133849020346 binding surface 1133849020347 TPR motif; other site 1133849020348 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1133849020349 active site 1133849020350 homodimer interface [polypeptide binding]; other site 1133849020351 SAM binding site [chemical binding]; other site 1133849020352 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1133849020353 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1133849020354 active site 1133849020355 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1133849020356 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1133849020357 domain interfaces; other site 1133849020358 active site 1133849020359 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1133849020360 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1133849020361 tRNA; other site 1133849020362 putative tRNA binding site [nucleotide binding]; other site 1133849020363 putative NADP binding site [chemical binding]; other site 1133849020364 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1133849020365 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1133849020366 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1133849020367 CoA binding domain; Region: CoA_binding; pfam02629 1133849020368 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1133849020369 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1133849020370 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1133849020371 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1133849020372 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1133849020373 putative acyl-acceptor binding pocket; other site 1133849020374 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1133849020375 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849020376 NAD(P) binding site [chemical binding]; other site 1133849020377 active site 1133849020378 DNA binding domain, excisionase family; Region: excise; TIGR01764 1133849020379 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1133849020380 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1133849020381 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1133849020382 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1133849020383 active site 2 [active] 1133849020384 active site 1 [active] 1133849020385 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1133849020386 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1133849020387 DNA interaction; other site 1133849020388 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1133849020389 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1133849020390 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1133849020391 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849020392 active site 1133849020393 phosphorylation site [posttranslational modification] 1133849020394 intermolecular recognition site; other site 1133849020395 dimerization interface [polypeptide binding]; other site 1133849020396 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1133849020397 DNA binding site [nucleotide binding] 1133849020398 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1133849020399 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1133849020400 dimer interface [polypeptide binding]; other site 1133849020401 phosphorylation site [posttranslational modification] 1133849020402 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849020403 ATP binding site [chemical binding]; other site 1133849020404 Mg2+ binding site [ion binding]; other site 1133849020405 G-X-G motif; other site 1133849020406 Predicted transcriptional regulators [Transcription]; Region: COG1733 1133849020407 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1133849020408 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1133849020409 Predicted acyl esterases [General function prediction only]; Region: COG2936 1133849020410 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1133849020411 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1133849020412 Predicted acyl esterases [General function prediction only]; Region: COG2936 1133849020413 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1133849020414 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1133849020415 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1133849020416 catalytic core [active] 1133849020417 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1133849020418 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1133849020419 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1133849020420 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1133849020421 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1133849020422 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1133849020423 putative ADP-binding pocket [chemical binding]; other site 1133849020424 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1133849020425 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849020426 TAP-like protein; Region: Abhydrolase_4; pfam08386 1133849020427 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1133849020428 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849020429 NAD(P) binding site [chemical binding]; other site 1133849020430 active site 1133849020431 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1133849020432 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1133849020433 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1133849020434 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1133849020435 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1133849020436 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1133849020437 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1133849020438 FAD binding domain; Region: FAD_binding_4; pfam01565 1133849020439 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1133849020440 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1133849020441 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1133849020442 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1133849020443 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1133849020444 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1133849020445 intersubunit interface [polypeptide binding]; other site 1133849020446 catalytic residue [active] 1133849020447 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1133849020448 Coenzyme A binding pocket [chemical binding]; other site 1133849020449 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1133849020450 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1133849020451 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1133849020452 putative active site [active] 1133849020453 putative substrate binding site [chemical binding]; other site 1133849020454 putative cosubstrate binding site; other site 1133849020455 catalytic site [active] 1133849020456 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849020457 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 1133849020458 mannonate dehydratase; Provisional; Region: PRK03906 1133849020459 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1133849020460 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849020461 non-specific DNA binding site [nucleotide binding]; other site 1133849020462 salt bridge; other site 1133849020463 sequence-specific DNA binding site [nucleotide binding]; other site 1133849020464 Predicted membrane protein [Function unknown]; Region: COG2733 1133849020465 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849020466 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849020467 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1133849020468 ABC1 family; Region: ABC1; cl17513 1133849020469 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; cl17526 1133849020470 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1133849020471 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1133849020472 NAD(P) binding pocket [chemical binding]; other site 1133849020473 Beta-lactamase; Region: Beta-lactamase; pfam00144 1133849020474 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1133849020475 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1133849020476 Beta-lactamase; Region: Beta-lactamase; pfam00144 1133849020477 EspG family; Region: ESX-1_EspG; pfam14011 1133849020478 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 1133849020479 probable F420-dependent oxidoreductase, MSMEG_3544 family; Region: F420_MSMEG_3544; TIGR03854 1133849020480 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1133849020481 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1133849020482 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1133849020483 catalytic residues [active] 1133849020484 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1133849020485 putative active site [active] 1133849020486 redox center [active] 1133849020487 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1133849020488 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1133849020489 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1133849020490 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1133849020491 putative NAD(P) binding site [chemical binding]; other site 1133849020492 putative substrate binding site [chemical binding]; other site 1133849020493 catalytic Zn binding site [ion binding]; other site 1133849020494 structural Zn binding site [ion binding]; other site 1133849020495 dimer interface [polypeptide binding]; other site 1133849020496 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1133849020497 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1133849020498 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 1133849020499 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1133849020500 Clp amino terminal domain; Region: Clp_N; pfam02861 1133849020501 Beta-lactamase; Region: Beta-lactamase; pfam00144 1133849020502 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1133849020503 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1133849020504 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1133849020505 THF binding site; other site 1133849020506 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1133849020507 substrate binding site [chemical binding]; other site 1133849020508 THF binding site; other site 1133849020509 zinc-binding site [ion binding]; other site 1133849020510 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 1133849020511 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1133849020512 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1133849020513 isocitrate lyase; Provisional; Region: PRK15063 1133849020514 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1133849020515 tetramer interface [polypeptide binding]; other site 1133849020516 active site 1133849020517 Mg2+/Mn2+ binding site [ion binding]; other site 1133849020518 Secretory lipase; Region: LIP; pfam03583 1133849020519 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1133849020520 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1133849020521 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 1133849020522 active site 1133849020523 catalytic site [active] 1133849020524 tetramer interface [polypeptide binding]; other site 1133849020525 allantoicase; Provisional; Region: PRK13257 1133849020526 Allantoicase repeat; Region: Allantoicase; pfam03561 1133849020527 Allantoicase repeat; Region: Allantoicase; pfam03561 1133849020528 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1133849020529 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1133849020530 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1133849020531 catalytic loop [active] 1133849020532 iron binding site [ion binding]; other site 1133849020533 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1133849020534 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1133849020535 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1133849020536 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1133849020537 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1133849020538 Biofilm formation and stress response factor; Region: BsmA; cl01794 1133849020539 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1133849020540 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 1133849020541 metal binding site [ion binding]; metal-binding site 1133849020542 dimer interface [polypeptide binding]; other site 1133849020543 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1133849020544 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849020545 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1133849020546 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1133849020547 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 1133849020548 active site 1133849020549 putative substrate binding pocket [chemical binding]; other site 1133849020550 urate oxidase; Region: urate_oxi; TIGR03383 1133849020551 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1133849020552 active site 1133849020553 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1133849020554 active site 1133849020555 homotetramer interface [polypeptide binding]; other site 1133849020556 putative OHCU decarboxylase; Provisional; Region: PRK13798 1133849020557 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1133849020558 Ligand binding site; other site 1133849020559 metal-binding site 1133849020560 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1133849020561 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 1133849020562 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1133849020563 NMT1/THI5 like; Region: NMT1; pfam09084 1133849020564 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1133849020565 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1133849020566 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 1133849020567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849020568 dimer interface [polypeptide binding]; other site 1133849020569 conserved gate region; other site 1133849020570 putative PBP binding loops; other site 1133849020571 ABC-ATPase subunit interface; other site 1133849020572 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1133849020573 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1133849020574 Walker A/P-loop; other site 1133849020575 ATP binding site [chemical binding]; other site 1133849020576 Q-loop/lid; other site 1133849020577 ABC transporter signature motif; other site 1133849020578 Walker B; other site 1133849020579 D-loop; other site 1133849020580 H-loop/switch region; other site 1133849020581 Isochorismatase family; Region: Isochorismatase; pfam00857 1133849020582 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1133849020583 catalytic triad [active] 1133849020584 conserved cis-peptide bond; other site 1133849020585 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1133849020586 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1133849020587 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1133849020588 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1133849020589 homodimer interface [polypeptide binding]; other site 1133849020590 active site 1133849020591 TDP-binding site; other site 1133849020592 acceptor substrate-binding pocket; other site 1133849020593 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849020594 Cytochrome P450; Region: p450; cl12078 1133849020595 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 1133849020596 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849020597 dimerization interface [polypeptide binding]; other site 1133849020598 putative DNA binding site [nucleotide binding]; other site 1133849020599 putative Zn2+ binding site [ion binding]; other site 1133849020600 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1133849020601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849020602 S-adenosylmethionine binding site [chemical binding]; other site 1133849020603 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849020604 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849020605 Cytochrome P450; Region: p450; cl12078 1133849020606 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849020607 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1133849020608 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1133849020609 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1133849020610 Predicted acyl esterases [General function prediction only]; Region: COG2936 1133849020611 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 1133849020612 acyl-CoA synthetase; Validated; Region: PRK07788 1133849020613 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849020614 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849020615 active site 1133849020616 CoA binding site [chemical binding]; other site 1133849020617 AMP binding site [chemical binding]; other site 1133849020618 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849020619 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849020620 Secretory lipase; Region: LIP; pfam03583 1133849020621 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1133849020622 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849020623 dimer interface [polypeptide binding]; other site 1133849020624 conserved gate region; other site 1133849020625 putative PBP binding loops; other site 1133849020626 ABC-ATPase subunit interface; other site 1133849020627 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1133849020628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849020629 dimer interface [polypeptide binding]; other site 1133849020630 conserved gate region; other site 1133849020631 putative PBP binding loops; other site 1133849020632 ABC-ATPase subunit interface; other site 1133849020633 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1133849020634 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1133849020635 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1133849020636 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1133849020637 dimer interface [polypeptide binding]; other site 1133849020638 active site 1133849020639 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1133849020640 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1133849020641 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1133849020642 nucleotide binding site [chemical binding]; other site 1133849020643 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1133849020644 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1133849020645 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1133849020646 active site 1133849020647 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1133849020648 putative substrate binding site [chemical binding]; other site 1133849020649 putative ATP binding site [chemical binding]; other site 1133849020650 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1133849020651 intersubunit interface [polypeptide binding]; other site 1133849020652 active site 1133849020653 zinc binding site [ion binding]; other site 1133849020654 Na+ binding site [ion binding]; other site 1133849020655 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1133849020656 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1133849020657 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1133849020658 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1133849020659 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849020660 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1133849020661 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1133849020662 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1133849020663 Secretory lipase; Region: LIP; pfam03583 1133849020664 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 1133849020665 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 1133849020666 active site 1133849020667 DNA binding site [nucleotide binding] 1133849020668 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 1133849020669 DNA binding site [nucleotide binding] 1133849020670 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1133849020671 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849020672 non-specific DNA binding site [nucleotide binding]; other site 1133849020673 salt bridge; other site 1133849020674 sequence-specific DNA binding site [nucleotide binding]; other site 1133849020675 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1133849020676 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1133849020677 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1133849020678 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849020679 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1133849020680 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849020681 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849020682 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1133849020683 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849020684 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849020685 active site 1133849020686 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1133849020687 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1133849020688 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1133849020689 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849020690 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849020691 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1133849020692 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849020693 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 1133849020694 putative dimer interface [polypeptide binding]; other site 1133849020695 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849020696 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1133849020697 active site 1133849020698 Predicted transcriptional regulators [Transcription]; Region: COG1733 1133849020699 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1133849020700 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1133849020701 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1133849020702 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1133849020703 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1133849020704 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1133849020705 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1133849020706 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1133849020707 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1133849020708 Helix-turn-helix domain; Region: HTH_18; pfam12833 1133849020709 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1133849020710 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1133849020711 NAD(P) binding site [chemical binding]; other site 1133849020712 substrate binding site [chemical binding]; other site 1133849020713 dimer interface [polypeptide binding]; other site 1133849020714 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1133849020715 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1133849020716 active site 1133849020717 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1133849020718 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1133849020719 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849020720 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1133849020721 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 1133849020722 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849020723 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849020724 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1133849020725 MarR family; Region: MarR_2; pfam12802 1133849020726 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1133849020727 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1133849020728 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1133849020729 ring oligomerisation interface [polypeptide binding]; other site 1133849020730 ATP/Mg binding site [chemical binding]; other site 1133849020731 stacking interactions; other site 1133849020732 hinge regions; other site 1133849020733 NAD synthetase; Reviewed; Region: nadE; PRK02628 1133849020734 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1133849020735 active site 1133849020736 catalytic triad [active] 1133849020737 multimer interface [polypeptide binding]; other site 1133849020738 protein interface 1 [polypeptide binding]; other site 1133849020739 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1133849020740 homodimer interface [polypeptide binding]; other site 1133849020741 NAD binding pocket [chemical binding]; other site 1133849020742 ATP binding pocket [chemical binding]; other site 1133849020743 Mg binding site [ion binding]; other site 1133849020744 active-site loop [active] 1133849020745 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1133849020746 Clp amino terminal domain; Region: Clp_N; pfam02861 1133849020747 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1133849020748 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 1133849020749 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1133849020750 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849020751 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1133849020752 DNA binding residues [nucleotide binding] 1133849020753 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1133849020754 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1133849020755 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1133849020756 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1133849020757 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1133849020758 dimer interface [polypeptide binding]; other site 1133849020759 active site 1133849020760 CoA binding pocket [chemical binding]; other site 1133849020761 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1133849020762 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1133849020763 hydrophobic ligand binding site; other site 1133849020764 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1133849020765 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849020766 active site 1133849020767 phosphorylation site [posttranslational modification] 1133849020768 intermolecular recognition site; other site 1133849020769 dimerization interface [polypeptide binding]; other site 1133849020770 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1133849020771 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1133849020772 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1133849020773 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1133849020774 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1133849020775 ligand binding site [chemical binding]; other site 1133849020776 flexible hinge region; other site 1133849020777 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1133849020778 ATP binding site [chemical binding]; other site 1133849020779 Mg2+ binding site [ion binding]; other site 1133849020780 G-X-G motif; other site 1133849020781 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 1133849020782 Cell division protein 48 (CDC48) N-terminal domain; Region: CDC48_N; smart01073 1133849020783 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 1133849020784 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 1133849020785 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1133849020786 Walker A motif; other site 1133849020787 ATP binding site [chemical binding]; other site 1133849020788 Walker B motif; other site 1133849020789 arginine finger; other site 1133849020790 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1133849020791 Walker A motif; other site 1133849020792 ATP binding site [chemical binding]; other site 1133849020793 Walker B motif; other site 1133849020794 arginine finger; other site 1133849020795 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 1133849020796 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1133849020797 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1133849020798 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1133849020799 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1133849020800 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 1133849020801 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 1133849020802 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1133849020803 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1133849020804 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 1133849020805 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 1133849020806 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 1133849020807 active site 1133849020808 carboxylate-amine ligase; Provisional; Region: PRK13517 1133849020809 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1133849020810 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1133849020811 E-class dimer interface [polypeptide binding]; other site 1133849020812 P-class dimer interface [polypeptide binding]; other site 1133849020813 active site 1133849020814 Cu2+ binding site [ion binding]; other site 1133849020815 Zn2+ binding site [ion binding]; other site 1133849020816 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1133849020817 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1133849020818 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1133849020819 active site 1133849020820 catalytic residues [active] 1133849020821 metal binding site [ion binding]; metal-binding site 1133849020822 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1133849020823 Coenzyme A binding pocket [chemical binding]; other site 1133849020824 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1133849020825 putative catalytic site [active] 1133849020826 putative phosphate binding site [ion binding]; other site 1133849020827 active site 1133849020828 metal binding site A [ion binding]; metal-binding site 1133849020829 DNA binding site [nucleotide binding] 1133849020830 putative AP binding site [nucleotide binding]; other site 1133849020831 putative metal binding site B [ion binding]; other site 1133849020832 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1133849020833 putative active site [active] 1133849020834 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1133849020835 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849020836 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1133849020837 active site 1133849020838 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849020839 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849020840 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 1133849020841 fumarylacetoacetase; Region: PLN02856 1133849020842 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 1133849020843 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1133849020844 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849020845 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849020846 Secretory lipase; Region: LIP; pfam03583 1133849020847 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1133849020848 ThiC-associated domain; Region: ThiC-associated; pfam13667 1133849020849 ThiC family; Region: ThiC; pfam01964 1133849020850 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849020851 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1133849020852 NAD(P) binding site [chemical binding]; other site 1133849020853 active site 1133849020854 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1133849020855 classical (c) SDRs; Region: SDR_c; cd05233 1133849020856 NAD(P) binding site [chemical binding]; other site 1133849020857 active site 1133849020858 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 1133849020859 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1133849020860 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849020861 salt bridge; other site 1133849020862 non-specific DNA binding site [nucleotide binding]; other site 1133849020863 sequence-specific DNA binding site [nucleotide binding]; other site 1133849020864 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1133849020865 Putative esterase; Region: Esterase; pfam00756 1133849020866 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1133849020867 DNA-binding site [nucleotide binding]; DNA binding site 1133849020868 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1133849020869 hypothetical protein; Provisional; Region: PRK08204 1133849020870 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1133849020871 active site 1133849020872 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1133849020873 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1133849020874 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 1133849020875 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1133849020876 active site 1133849020877 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1133849020878 active site 1133849020879 metal binding site [ion binding]; metal-binding site 1133849020880 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1133849020881 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1133849020882 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1133849020883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849020884 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1133849020885 Septum formation; Region: Septum_form; pfam13845 1133849020886 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849020887 Cytochrome P450; Region: p450; cl12078 1133849020888 DoxX-like family; Region: DoxX_2; pfam13564 1133849020889 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1133849020890 potential frameshift: common BLAST hit: gi|271965880|ref|YP_003340076.1| oxygenase 1133849020891 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1133849020892 active site 1133849020893 catalytic triad [active] 1133849020894 oxyanion hole [active] 1133849020895 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1133849020896 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1133849020897 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849020898 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849020899 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1133849020900 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1133849020901 dimer interface [polypeptide binding]; other site 1133849020902 active site 1133849020903 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1133849020904 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1133849020905 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1133849020906 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849020907 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849020908 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1133849020909 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849020910 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1133849020911 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1133849020912 NAD binding site [chemical binding]; other site 1133849020913 substrate binding site [chemical binding]; other site 1133849020914 putative active site [active] 1133849020915 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1133849020916 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1133849020917 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1133849020918 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1133849020919 dimer interface [polypeptide binding]; other site 1133849020920 substrate binding site [chemical binding]; other site 1133849020921 ATP binding site [chemical binding]; other site 1133849020922 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849020923 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849020924 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1133849020925 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1133849020926 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1133849020927 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1133849020928 AsnC family; Region: AsnC_trans_reg; pfam01037 1133849020929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849020930 putative substrate translocation pore; other site 1133849020931 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 1133849020932 Ligand binding site; other site 1133849020933 Ligand binding site; other site 1133849020934 Ligand binding site; other site 1133849020935 Putative Catalytic site; other site 1133849020936 DXD motif; other site 1133849020937 Predicted membrane protein [Function unknown]; Region: COG2246 1133849020938 GtrA-like protein; Region: GtrA; pfam04138 1133849020939 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1133849020940 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849020941 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1133849020942 NAD(P) binding site [chemical binding]; other site 1133849020943 active site 1133849020944 Phosphotransferase enzyme family; Region: APH; pfam01636 1133849020945 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1133849020946 active site 1133849020947 substrate binding site [chemical binding]; other site 1133849020948 ATP binding site [chemical binding]; other site 1133849020949 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849020950 ABC transporter signature motif; other site 1133849020951 Walker B; other site 1133849020952 D-loop; other site 1133849020953 enoyl-CoA hydratase; Provisional; Region: PRK07827 1133849020954 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1133849020955 substrate binding site [chemical binding]; other site 1133849020956 oxyanion hole (OAH) forming residues; other site 1133849020957 trimer interface [polypeptide binding]; other site 1133849020958 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 1133849020959 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1133849020960 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1133849020961 active site 1133849020962 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1133849020963 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1133849020964 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1133849020965 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1133849020966 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1133849020967 carboxyltransferase (CT) interaction site; other site 1133849020968 biotinylation site [posttranslational modification]; other site 1133849020969 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1133849020970 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1133849020971 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849020972 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849020973 active site 1133849020974 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1133849020975 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1133849020976 cyclase homology domain; Region: CHD; cd07302 1133849020977 nucleotidyl binding site; other site 1133849020978 metal binding site [ion binding]; metal-binding site 1133849020979 dimer interface [polypeptide binding]; other site 1133849020980 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1133849020981 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1133849020982 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1133849020983 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1133849020984 Walker A/P-loop; other site 1133849020985 ATP binding site [chemical binding]; other site 1133849020986 Q-loop/lid; other site 1133849020987 ABC transporter signature motif; other site 1133849020988 Walker B; other site 1133849020989 D-loop; other site 1133849020990 H-loop/switch region; other site 1133849020991 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1133849020992 ThiS interaction site; other site 1133849020993 putative active site [active] 1133849020994 tetramer interface [polypeptide binding]; other site 1133849020995 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1133849020996 thiS-thiF/thiG interaction site; other site 1133849020997 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1133849020998 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1133849020999 thiamine phosphate binding site [chemical binding]; other site 1133849021000 active site 1133849021001 pyrophosphate binding site [ion binding]; other site 1133849021002 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1133849021003 nudix motif; other site 1133849021004 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1133849021005 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1133849021006 substrate binding pocket [chemical binding]; other site 1133849021007 membrane-bound complex binding site; other site 1133849021008 hinge residues; other site 1133849021009 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1133849021010 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1133849021011 active site 1133849021012 ATP binding site [chemical binding]; other site 1133849021013 substrate binding site [chemical binding]; other site 1133849021014 activation loop (A-loop); other site 1133849021015 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1133849021016 propionate/acetate kinase; Provisional; Region: PRK12379 1133849021017 phosphate acetyltransferase; Reviewed; Region: PRK05632 1133849021018 DRTGG domain; Region: DRTGG; pfam07085 1133849021019 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1133849021020 Domain of unknown function (DUF385); Region: DUF385; cl04387 1133849021021 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1133849021022 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 1133849021023 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1133849021024 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1133849021025 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1133849021026 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1133849021027 active site 1133849021028 motif I; other site 1133849021029 motif II; other site 1133849021030 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1133849021031 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1133849021032 DNA binding site [nucleotide binding] 1133849021033 active site 1133849021034 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849021035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1133849021036 Walker A motif; other site 1133849021037 ATP binding site [chemical binding]; other site 1133849021038 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849021039 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849021040 DNA binding residues [nucleotide binding] 1133849021041 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1133849021042 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1133849021043 GDP-binding site [chemical binding]; other site 1133849021044 ACT binding site; other site 1133849021045 IMP binding site; other site 1133849021046 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1133849021047 Peptidase family M50; Region: Peptidase_M50; pfam02163 1133849021048 active site 1133849021049 putative substrate binding region [chemical binding]; other site 1133849021050 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1133849021051 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1133849021052 DXD motif; other site 1133849021053 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1133849021054 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1133849021055 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 1133849021056 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1133849021057 active site 1133849021058 catalytic site [active] 1133849021059 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1133849021060 active site 1133849021061 catalytic site [active] 1133849021062 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 1133849021063 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1133849021064 DNA binding site [nucleotide binding] 1133849021065 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1133849021066 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1133849021067 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1133849021068 phosphopeptide binding site; other site 1133849021069 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1133849021070 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1133849021071 active site 1133849021072 intersubunit interface [polypeptide binding]; other site 1133849021073 zinc binding site [ion binding]; other site 1133849021074 Na+ binding site [ion binding]; other site 1133849021075 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1133849021076 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1133849021077 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1133849021078 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1133849021079 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 1133849021080 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1133849021081 Putative sensor; Region: Sensor; pfam13796 1133849021082 Histidine kinase; Region: HisKA_3; pfam07730 1133849021083 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1133849021084 Mg2+ binding site [ion binding]; other site 1133849021085 G-X-G motif; other site 1133849021086 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849021087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849021088 active site 1133849021089 phosphorylation site [posttranslational modification] 1133849021090 intermolecular recognition site; other site 1133849021091 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849021092 DNA binding residues [nucleotide binding] 1133849021093 dimerization interface [polypeptide binding]; other site 1133849021094 YhhN-like protein; Region: YhhN; pfam07947 1133849021095 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 1133849021096 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1133849021097 dimer interface [polypeptide binding]; other site 1133849021098 active site 1133849021099 CoA binding pocket [chemical binding]; other site 1133849021100 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1133849021101 active site 1133849021102 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1133849021103 classical (c) SDRs; Region: SDR_c; cd05233 1133849021104 NAD(P) binding site [chemical binding]; other site 1133849021105 active site 1133849021106 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1133849021107 Clp amino terminal domain; Region: Clp_N; pfam02861 1133849021108 Clp amino terminal domain; Region: Clp_N; pfam02861 1133849021109 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1133849021110 Walker A motif; other site 1133849021111 ATP binding site [chemical binding]; other site 1133849021112 Walker B motif; other site 1133849021113 arginine finger; other site 1133849021114 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1133849021115 Walker A motif; other site 1133849021116 ATP binding site [chemical binding]; other site 1133849021117 Walker B motif; other site 1133849021118 arginine finger; other site 1133849021119 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1133849021120 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1133849021121 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1133849021122 Walker A motif; other site 1133849021123 ATP binding site [chemical binding]; other site 1133849021124 Walker B motif; other site 1133849021125 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1133849021126 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1133849021127 putative NAD(P) binding site [chemical binding]; other site 1133849021128 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1133849021129 heme-binding site [chemical binding]; other site 1133849021130 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 1133849021131 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 1133849021132 FAD binding pocket [chemical binding]; other site 1133849021133 FAD binding motif [chemical binding]; other site 1133849021134 phosphate binding motif [ion binding]; other site 1133849021135 beta-alpha-beta structure motif; other site 1133849021136 NAD binding pocket [chemical binding]; other site 1133849021137 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 1133849021138 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 1133849021139 FAD binding pocket [chemical binding]; other site 1133849021140 FAD binding motif [chemical binding]; other site 1133849021141 phosphate binding motif [ion binding]; other site 1133849021142 beta-alpha-beta structure motif; other site 1133849021143 NAD binding pocket [chemical binding]; other site 1133849021144 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1133849021145 heme-binding site [chemical binding]; other site 1133849021146 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 1133849021147 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 1133849021148 FAD binding pocket [chemical binding]; other site 1133849021149 FAD binding motif [chemical binding]; other site 1133849021150 phosphate binding motif [ion binding]; other site 1133849021151 beta-alpha-beta structure motif; other site 1133849021152 NAD binding pocket [chemical binding]; other site 1133849021153 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1133849021154 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1133849021155 DNA binding residues [nucleotide binding] 1133849021156 chaperone protein DnaJ; Provisional; Region: PRK14279 1133849021157 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1133849021158 HSP70 interaction site [polypeptide binding]; other site 1133849021159 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1133849021160 Zn binding sites [ion binding]; other site 1133849021161 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1133849021162 dimer interface [polypeptide binding]; other site 1133849021163 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1133849021164 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1133849021165 dimer interface [polypeptide binding]; other site 1133849021166 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1133849021167 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1133849021168 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1133849021169 nucleotide binding site [chemical binding]; other site 1133849021170 NEF interaction site [polypeptide binding]; other site 1133849021171 SBD interface [polypeptide binding]; other site 1133849021172 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1133849021173 FAD binding domain; Region: FAD_binding_4; pfam01565 1133849021174 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849021175 putative substrate translocation pore; other site 1133849021176 Predicted transcriptional regulators [Transcription]; Region: COG1733 1133849021177 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1133849021178 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1133849021179 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 1133849021180 putative NAD(P) binding site [chemical binding]; other site 1133849021181 catalytic Zn binding site [ion binding]; other site 1133849021182 hypothetical protein; Validated; Region: PRK05868 1133849021183 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1133849021184 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849021185 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849021186 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1133849021187 Dynamin family; Region: Dynamin_N; pfam00350 1133849021188 G1 box; other site 1133849021189 GTP/Mg2+ binding site [chemical binding]; other site 1133849021190 G2 box; other site 1133849021191 Switch I region; other site 1133849021192 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 1133849021193 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1133849021194 G1 box; other site 1133849021195 GTP/Mg2+ binding site [chemical binding]; other site 1133849021196 G2 box; other site 1133849021197 Switch I region; other site 1133849021198 G3 box; other site 1133849021199 Switch II region; other site 1133849021200 G4 box; other site 1133849021201 G5 box; other site 1133849021202 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1133849021203 nucleotide binding site [chemical binding]; other site 1133849021204 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 1133849021205 DNA binding residues [nucleotide binding] 1133849021206 NRDE protein; Region: NRDE; cl01315 1133849021207 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1133849021208 Cysteine-rich domain; Region: CCG; pfam02754 1133849021209 Cysteine-rich domain; Region: CCG; pfam02754 1133849021210 DNA binding domain, excisionase family; Region: excise; TIGR01764 1133849021211 PIN domain; Region: PIN_3; pfam13470 1133849021212 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1133849021213 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1133849021214 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1133849021215 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1133849021216 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849021217 active site 1133849021218 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1133849021219 putative active site [active] 1133849021220 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1133849021221 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1133849021222 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1133849021223 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1133849021224 YibE/F-like protein; Region: YibE_F; pfam07907 1133849021225 aminotransferase AlaT; Validated; Region: PRK09265 1133849021226 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1133849021227 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849021228 homodimer interface [polypeptide binding]; other site 1133849021229 catalytic residue [active] 1133849021230 Helix-turn-helix domain; Region: HTH_18; pfam12833 1133849021231 Tetratrico peptide repeat; Region: TPR_5; pfam12688 1133849021232 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1133849021233 trimer interface [polypeptide binding]; other site 1133849021234 active site 1133849021235 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1133849021236 classical (c) SDRs; Region: SDR_c; cd05233 1133849021237 NAD(P) binding site [chemical binding]; other site 1133849021238 active site 1133849021239 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1133849021240 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1133849021241 active site 1133849021242 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1133849021243 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1133849021244 Beta-lactamase; Region: Beta-lactamase; pfam00144 1133849021245 MspA; Region: MspA; pfam09203 1133849021246 Short C-terminal domain; Region: SHOCT; pfam09851 1133849021247 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1133849021248 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849021249 S-adenosylmethionine binding site [chemical binding]; other site 1133849021250 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1133849021251 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1133849021252 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1133849021253 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1133849021254 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849021255 active site 1133849021256 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 1133849021257 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1133849021258 active site 1133849021259 dimer interface [polypeptide binding]; other site 1133849021260 non-prolyl cis peptide bond; other site 1133849021261 insertion regions; other site 1133849021262 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1133849021263 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1133849021264 GAF domain; Region: GAF_2; pfam13185 1133849021265 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1133849021266 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1133849021267 active site 1133849021268 non-prolyl cis peptide bond; other site 1133849021269 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1133849021270 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849021271 active site 1133849021272 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 1133849021273 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849021274 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849021275 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849021276 enoyl-CoA hydratase; Provisional; Region: PRK08252 1133849021277 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1133849021278 substrate binding site [chemical binding]; other site 1133849021279 oxyanion hole (OAH) forming residues; other site 1133849021280 trimer interface [polypeptide binding]; other site 1133849021281 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 1133849021282 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1133849021283 active site 1133849021284 enoyl-CoA hydratase; Provisional; Region: PRK07509 1133849021285 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1133849021286 substrate binding site [chemical binding]; other site 1133849021287 oxyanion hole (OAH) forming residues; other site 1133849021288 trimer interface [polypeptide binding]; other site 1133849021289 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1133849021290 Erythromycin esterase; Region: Erythro_esteras; cl17110 1133849021291 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849021292 S-adenosylmethionine binding site [chemical binding]; other site 1133849021293 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1133849021294 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1133849021295 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 1133849021296 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1133849021297 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1133849021298 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 1133849021299 FAD binding site [chemical binding]; other site 1133849021300 substrate binding site [chemical binding]; other site 1133849021301 catalytic residues [active] 1133849021302 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1133849021303 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1133849021304 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1133849021305 metal binding site [ion binding]; metal-binding site 1133849021306 active site 1133849021307 I-site; other site 1133849021308 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1133849021309 VanW like protein; Region: VanW; pfam04294 1133849021310 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1133849021311 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1133849021312 Secretory lipase; Region: LIP; pfam03583 1133849021313 short chain dehydrogenase; Validated; Region: PRK05855 1133849021314 classical (c) SDRs; Region: SDR_c; cd05233 1133849021315 NAD(P) binding site [chemical binding]; other site 1133849021316 active site 1133849021317 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 1133849021318 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1133849021319 dimer interface [polypeptide binding]; other site 1133849021320 active site 1133849021321 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 1133849021322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849021323 NAD(P) binding site [chemical binding]; other site 1133849021324 active site 1133849021325 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1133849021326 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1133849021327 active site 2 [active] 1133849021328 active site 1 [active] 1133849021329 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849021330 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849021331 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1133849021332 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1133849021333 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1133849021334 Ligand Binding Site [chemical binding]; other site 1133849021335 isochorismate synthase DhbC; Validated; Region: PRK06923 1133849021336 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1133849021337 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 1133849021338 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 1133849021339 DinB superfamily; Region: DinB_2; pfam12867 1133849021340 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1133849021341 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1133849021342 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1133849021343 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1133849021344 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1133849021345 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849021346 S-adenosylmethionine binding site [chemical binding]; other site 1133849021347 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1133849021348 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1133849021349 NAD binding site [chemical binding]; other site 1133849021350 catalytic residues [active] 1133849021351 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1133849021352 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1133849021353 conserved cys residue [active] 1133849021354 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849021355 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1133849021356 spermine synthase; Region: PLN02823 1133849021357 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1133849021358 active site 1133849021359 substrate-binding site [chemical binding]; other site 1133849021360 metal-binding site [ion binding] 1133849021361 GTP binding site [chemical binding]; other site 1133849021362 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1133849021363 Switch II region; other site 1133849021364 G4 box; other site 1133849021365 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849021366 short chain dehydrogenase; Provisional; Region: PRK08267 1133849021367 NAD(P) binding site [chemical binding]; other site 1133849021368 active site 1133849021369 Secretory lipase; Region: LIP; pfam03583 1133849021370 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1133849021371 LabA_like proteins; Region: LabA_like; cd06167 1133849021372 putative metal binding site [ion binding]; other site 1133849021373 MMPL family; Region: MMPL; pfam03176 1133849021374 MMPL family; Region: MMPL; pfam03176 1133849021375 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1133849021376 putative active site [active] 1133849021377 oxidase reductase; Provisional; Region: PTZ00273 1133849021378 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1133849021379 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1133849021380 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1133849021381 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849021382 non-specific DNA binding site [nucleotide binding]; other site 1133849021383 salt bridge; other site 1133849021384 sequence-specific DNA binding site [nucleotide binding]; other site 1133849021385 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1133849021386 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849021387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849021388 active site 1133849021389 phosphorylation site [posttranslational modification] 1133849021390 intermolecular recognition site; other site 1133849021391 dimerization interface [polypeptide binding]; other site 1133849021392 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849021393 DNA binding residues [nucleotide binding] 1133849021394 dimerization interface [polypeptide binding]; other site 1133849021395 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1133849021396 ATP binding site [chemical binding]; other site 1133849021397 G-X-G motif; other site 1133849021398 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1133849021399 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1133849021400 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1133849021401 dimerization interface [polypeptide binding]; other site 1133849021402 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1133849021403 cyclase homology domain; Region: CHD; cd07302 1133849021404 nucleotidyl binding site; other site 1133849021405 metal binding site [ion binding]; metal-binding site 1133849021406 dimer interface [polypeptide binding]; other site 1133849021407 Predicted integral membrane protein [Function unknown]; Region: COG0392 1133849021408 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1133849021409 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1133849021410 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1133849021411 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1133849021412 trimer interface [polypeptide binding]; other site 1133849021413 active site 1133849021414 dimer interface [polypeptide binding]; other site 1133849021415 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1133849021416 Predicted transcriptional regulators [Transcription]; Region: COG1733 1133849021417 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1133849021418 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 1133849021419 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1133849021420 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1133849021421 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849021422 non-specific DNA binding site [nucleotide binding]; other site 1133849021423 salt bridge; other site 1133849021424 sequence-specific DNA binding site [nucleotide binding]; other site 1133849021425 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1133849021426 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1133849021427 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1133849021428 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1133849021429 Walker A/P-loop; other site 1133849021430 ATP binding site [chemical binding]; other site 1133849021431 Q-loop/lid; other site 1133849021432 ABC transporter signature motif; other site 1133849021433 Walker B; other site 1133849021434 D-loop; other site 1133849021435 H-loop/switch region; other site 1133849021436 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1133849021437 dimerization interface [polypeptide binding]; other site 1133849021438 putative DNA binding site [nucleotide binding]; other site 1133849021439 putative Zn2+ binding site [ion binding]; other site 1133849021440 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 1133849021441 putative hydrophobic ligand binding site [chemical binding]; other site 1133849021442 Protein of unknown function (DUF419); Region: DUF419; pfam04237 1133849021443 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849021444 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849021445 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849021446 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR8; cd08273 1133849021447 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1133849021448 putative NAD(P) binding site [chemical binding]; other site 1133849021449 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849021450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1133849021451 active site 1133849021452 phosphorylation site [posttranslational modification] 1133849021453 intermolecular recognition site; other site 1133849021454 dimerization interface [polypeptide binding]; other site 1133849021455 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849021456 DNA binding residues [nucleotide binding] 1133849021457 dimerization interface [polypeptide binding]; other site 1133849021458 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1133849021459 SecY translocase; Region: SecY; pfam00344 1133849021460 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1133849021461 FMN binding site [chemical binding]; other site 1133849021462 dimer interface [polypeptide binding]; other site 1133849021463 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1133849021464 TAP-like protein; Region: Abhydrolase_4; pfam08386 1133849021465 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1133849021466 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1133849021467 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1133849021468 putative acyl-acceptor binding pocket; other site 1133849021469 hypothetical protein; Validated; Region: PRK00228 1133849021470 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 1133849021471 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1133849021472 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1133849021473 DNA binding residues [nucleotide binding] 1133849021474 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1133849021475 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1133849021476 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849021477 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1133849021478 Walker A/P-loop; other site 1133849021479 ATP binding site [chemical binding]; other site 1133849021480 Q-loop/lid; other site 1133849021481 ABC transporter signature motif; other site 1133849021482 Walker B; other site 1133849021483 D-loop; other site 1133849021484 H-loop/switch region; other site 1133849021485 EXLDI protein; Region: EXLDI; TIGR04342 1133849021486 MspA; Region: MspA; pfam09203 1133849021487 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1133849021488 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1133849021489 PYR/PP interface [polypeptide binding]; other site 1133849021490 dimer interface [polypeptide binding]; other site 1133849021491 TPP binding site [chemical binding]; other site 1133849021492 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1133849021493 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1133849021494 TPP-binding site [chemical binding]; other site 1133849021495 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 1133849021496 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1133849021497 active site 1133849021498 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1133849021499 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1133849021500 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1133849021501 homodimer interface [polypeptide binding]; other site 1133849021502 catalytic residue [active] 1133849021503 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1133849021504 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1133849021505 hypothetical protein; Provisional; Region: PRK05409 1133849021506 SdpI/YhfL protein family; Region: SdpI; pfam13630 1133849021507 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1133849021508 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1133849021509 HIGH motif; other site 1133849021510 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1133849021511 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1133849021512 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1133849021513 active site 1133849021514 KMSKS motif; other site 1133849021515 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1133849021516 tRNA binding surface [nucleotide binding]; other site 1133849021517 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1133849021518 short chain dehydrogenase; Provisional; Region: PRK08219 1133849021519 classical (c) SDRs; Region: SDR_c; cd05233 1133849021520 NAD(P) binding site [chemical binding]; other site 1133849021521 active site 1133849021522 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 1133849021523 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 1133849021524 active site 1133849021525 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1133849021526 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 1133849021527 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1133849021528 binding surface 1133849021529 TPR motif; other site 1133849021530 CHAT domain; Region: CHAT; cl17868 1133849021531 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849021532 Predicted ATPase [General function prediction only]; Region: COG3910 1133849021533 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849021534 Walker A/P-loop; other site 1133849021535 ATP binding site [chemical binding]; other site 1133849021536 Q-loop/lid; other site 1133849021537 ABC transporter signature motif; other site 1133849021538 Walker B; other site 1133849021539 D-loop; other site 1133849021540 H-loop/switch region; other site 1133849021541 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1133849021542 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1133849021543 Walker A/P-loop; other site 1133849021544 ATP binding site [chemical binding]; other site 1133849021545 Q-loop/lid; other site 1133849021546 ABC transporter signature motif; other site 1133849021547 Walker B; other site 1133849021548 D-loop; other site 1133849021549 H-loop/switch region; other site 1133849021550 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1133849021551 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1133849021552 substrate binding pocket [chemical binding]; other site 1133849021553 membrane-bound complex binding site; other site 1133849021554 hinge residues; other site 1133849021555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849021556 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1133849021557 dimer interface [polypeptide binding]; other site 1133849021558 conserved gate region; other site 1133849021559 putative PBP binding loops; other site 1133849021560 ABC-ATPase subunit interface; other site 1133849021561 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 1133849021562 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1133849021563 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1133849021564 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 1133849021565 gating phenylalanine in ion channel; other site 1133849021566 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1133849021567 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1133849021568 Walker A/P-loop; other site 1133849021569 ATP binding site [chemical binding]; other site 1133849021570 Q-loop/lid; other site 1133849021571 ABC transporter signature motif; other site 1133849021572 Walker B; other site 1133849021573 D-loop; other site 1133849021574 H-loop/switch region; other site 1133849021575 TOBE domain; Region: TOBE_2; pfam08402 1133849021576 Predicted transcriptional regulators [Transcription]; Region: COG1733 1133849021577 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1133849021578 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1133849021579 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1133849021580 dimer interface [polypeptide binding]; other site 1133849021581 active site 1133849021582 Predicted transcriptional regulators [Transcription]; Region: COG1733 1133849021583 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1133849021584 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1133849021585 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1133849021586 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1133849021587 active site 1133849021588 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 1133849021589 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1133849021590 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1133849021591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849021592 dimer interface [polypeptide binding]; other site 1133849021593 conserved gate region; other site 1133849021594 putative PBP binding loops; other site 1133849021595 ABC-ATPase subunit interface; other site 1133849021596 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1133849021597 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849021598 dimer interface [polypeptide binding]; other site 1133849021599 conserved gate region; other site 1133849021600 putative PBP binding loops; other site 1133849021601 ABC-ATPase subunit interface; other site 1133849021602 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1133849021603 Transglycosylase; Region: Transgly; pfam00912 1133849021604 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1133849021605 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1133849021606 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1133849021607 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1133849021608 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1133849021609 Predicted transcriptional regulators [Transcription]; Region: COG1695 1133849021610 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1133849021611 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1133849021612 Transglycosylase; Region: Transgly; pfam00912 1133849021613 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1133849021614 Predicted integral membrane protein [Function unknown]; Region: COG5650 1133849021615 Predicted integral membrane protein [Function unknown]; Region: COG5650 1133849021616 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1133849021617 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1133849021618 putative metal binding site [ion binding]; other site 1133849021619 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1133849021620 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1133849021621 putative metal binding site [ion binding]; other site 1133849021622 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1133849021623 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1133849021624 putative metal binding site [ion binding]; other site 1133849021625 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 1133849021626 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 1133849021627 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 1133849021628 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1133849021629 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849021630 NAD(P) binding site [chemical binding]; other site 1133849021631 active site 1133849021632 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1133849021633 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1133849021634 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1133849021635 DNA binding residues [nucleotide binding] 1133849021636 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192 1133849021637 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1133849021638 active site 1133849021639 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 1133849021640 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 1133849021641 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1133849021642 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 1133849021643 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1133849021644 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1133849021645 putative metal binding site [ion binding]; other site 1133849021646 hypothetical protein; Provisional; Region: PRK14013 1133849021647 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 1133849021648 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1133849021649 putative metal binding site [ion binding]; other site 1133849021650 EamA-like transporter family; Region: EamA; pfam00892 1133849021651 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 1133849021652 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1133849021653 CGNR zinc finger; Region: zf-CGNR; pfam11706 1133849021654 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1133849021655 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1133849021656 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1133849021657 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1133849021658 AAA ATPase domain; Region: AAA_16; pfam13191 1133849021659 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1133849021660 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1133849021661 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1133849021662 dimer interface [polypeptide binding]; other site 1133849021663 ssDNA binding site [nucleotide binding]; other site 1133849021664 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1133849021665 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1133849021666 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1133849021667 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1133849021668 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1133849021669 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1133849021670 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1133849021671 Walker A motif; other site 1133849021672 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442 1133849021673 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1133849021674 Walker B motif; other site 1133849021675 DNA binding loops [nucleotide binding] 1133849021676 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1133849021677 protein-splicing catalytic site; other site 1133849021678 thioester formation/cholesterol transfer; other site 1133849021679 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 1133849021680 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1133849021681 protein-splicing catalytic site; other site 1133849021682 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1133849021683 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1133849021684 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1133849021685 active site 1133849021686 ATP binding site [chemical binding]; other site 1133849021687 substrate binding site [chemical binding]; other site 1133849021688 activation loop (A-loop); other site 1133849021689 Lipase (class 2); Region: Lipase_2; pfam01674 1133849021690 Predicted transcriptional regulators [Transcription]; Region: COG1733 1133849021691 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1133849021692 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1133849021693 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1133849021694 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1133849021695 DNA binding residues [nucleotide binding] 1133849021696 dimerization interface [polypeptide binding]; other site 1133849021697 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1133849021698 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1133849021699 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1133849021700 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1133849021701 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1133849021702 beta-galactosidase; Region: BGL; TIGR03356 1133849021703 Caspase domain; Region: Peptidase_C14; pfam00656 1133849021704 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1133849021705 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1133849021706 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1133849021707 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1133849021708 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1133849021709 AAA domain; Region: AAA_31; pfam13614 1133849021710 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1133849021711 hypothetical protein; Provisional; Region: PRK06126 1133849021712 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1133849021713 Cutinase; Region: Cutinase; pfam01083 1133849021714 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1133849021715 EamA-like transporter family; Region: EamA; pfam00892 1133849021716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1133849021717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1133849021718 S-adenosylmethionine binding site [chemical binding]; other site 1133849021719 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1133849021720 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1133849021721 Nitronate monooxygenase; Region: NMO; pfam03060 1133849021722 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1133849021723 FMN binding site [chemical binding]; other site 1133849021724 substrate binding site [chemical binding]; other site 1133849021725 putative catalytic residue [active] 1133849021726 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1133849021727 putative hydrophobic ligand binding site [chemical binding]; other site 1133849021728 protein interface [polypeptide binding]; other site 1133849021729 gate; other site 1133849021730 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1133849021731 ABC1 family; Region: ABC1; pfam03109 1133849021732 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1133849021733 active site 1133849021734 ATP binding site [chemical binding]; other site 1133849021735 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1133849021736 DNA-binding site [nucleotide binding]; DNA binding site 1133849021737 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1133849021738 ABC1 family; Region: ABC1; cl17513 1133849021739 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1133849021740 active site 1133849021741 ATP binding site [chemical binding]; other site 1133849021742 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1133849021743 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1133849021744 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1133849021745 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1133849021746 classical (c) SDRs; Region: SDR_c; cd05233 1133849021747 NAD(P) binding site [chemical binding]; other site 1133849021748 active site 1133849021749 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1133849021750 NAD(P) binding site [chemical binding]; other site 1133849021751 active site 1133849021752 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979 1133849021753 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1133849021754 putative active site [active] 1133849021755 putative catalytic site [active] 1133849021756 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1133849021757 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1133849021758 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1133849021759 FMN binding site [chemical binding]; other site 1133849021760 substrate binding site [chemical binding]; other site 1133849021761 putative catalytic residue [active] 1133849021762 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 1133849021763 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1133849021764 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1133849021765 acyl-activating enzyme (AAE) consensus motif; other site 1133849021766 acyl-activating enzyme (AAE) consensus motif; other site 1133849021767 putative AMP binding site [chemical binding]; other site 1133849021768 putative active site [active] 1133849021769 putative CoA binding site [chemical binding]; other site 1133849021770 Isochorismatase family; Region: Isochorismatase; pfam00857 1133849021771 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1133849021772 catalytic triad [active] 1133849021773 conserved cis-peptide bond; other site 1133849021774 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1133849021775 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1133849021776 active site 1133849021777 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1133849021778 KR domain; Region: KR; pfam08659 1133849021779 short chain dehydrogenase; Region: adh_short; pfam00106 1133849021780 NAD(P) binding site [chemical binding]; other site 1133849021781 active site 1133849021782 acyl-CoA synthetase; Validated; Region: PRK05850 1133849021783 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1133849021784 acyl-activating enzyme (AAE) consensus motif; other site 1133849021785 active site 1133849021786 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1133849021787 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1133849021788 RNA binding surface [nucleotide binding]; other site 1133849021789 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1133849021790 NlpC/P60 family; Region: NLPC_P60; pfam00877 1133849021791 AAA ATPase domain; Region: AAA_16; pfam13191 1133849021792 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1133849021793 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1133849021794 active site 1133849021795 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1133849021796 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1133849021797 TAP-like protein; Region: Abhydrolase_4; pfam08386 1133849021798 sensory histidine kinase UhpB; Provisional; Region: PRK11644 1133849021799 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1133849021800 active site 1133849021801 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 1133849021802 L-aspartate oxidase; Provisional; Region: PRK06175 1133849021803 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1133849021804 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 1133849021805 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1133849021806 catalytic loop [active] 1133849021807 iron binding site [ion binding]; other site 1133849021808 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1133849021809 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1133849021810 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1133849021811 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1133849021812 non-specific DNA binding site [nucleotide binding]; other site 1133849021813 salt bridge; other site 1133849021814 sequence-specific DNA binding site [nucleotide binding]; other site 1133849021815 TAP-like protein; Region: Abhydrolase_4; pfam08386 1133849021816 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1133849021817 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1133849021818 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1133849021819 Walker A/P-loop; other site 1133849021820 ATP binding site [chemical binding]; other site 1133849021821 Q-loop/lid; other site 1133849021822 ABC transporter signature motif; other site 1133849021823 Walker B; other site 1133849021824 D-loop; other site 1133849021825 H-loop/switch region; other site 1133849021826 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1133849021827 FAD binding domain; Region: FAD_binding_4; pfam01565 1133849021828 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1133849021829 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1133849021830 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1133849021831 minor groove reading motif; other site 1133849021832 helix-hairpin-helix signature motif; other site 1133849021833 active site 1133849021834 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849021835 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849021836 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1133849021837 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1133849021838 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1133849021839 oligomeric interface; other site 1133849021840 putative active site [active] 1133849021841 homodimer interface [polypeptide binding]; other site 1133849021842 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1133849021843 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1133849021844 NADP binding site [chemical binding]; other site 1133849021845 dimer interface [polypeptide binding]; other site 1133849021846 DNA polymerase IV; Validated; Region: PRK03352 1133849021847 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1133849021848 active site 1133849021849 DNA binding site [nucleotide binding] 1133849021850 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1133849021851 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1133849021852 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1133849021853 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1133849021854 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1133849021855 CoenzymeA binding site [chemical binding]; other site 1133849021856 subunit interaction site [polypeptide binding]; other site 1133849021857 PHB binding site; other site 1133849021858 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1133849021859 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1133849021860 Walker A motif; other site 1133849021861 ATP binding site [chemical binding]; other site 1133849021862 Walker B motif; other site 1133849021863 arginine finger; other site 1133849021864 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1133849021865 RibD C-terminal domain; Region: RibD_C; cl17279 1133849021866 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1133849021867 Protease prsW family; Region: PrsW-protease; pfam13367 1133849021868 TIGR03084 family protein; Region: TIGR03084 1133849021869 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1133849021870 Wyosine base formation; Region: Wyosine_form; pfam08608 1133849021871 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1133849021872 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1133849021873 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1133849021874 hydrophobic ligand binding site; other site 1133849021875 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1133849021876 RNA/DNA hybrid binding site [nucleotide binding]; other site 1133849021877 active site 1133849021878 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1133849021879 mce related protein; Region: MCE; pfam02470 1133849021880 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1133849021881 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1133849021882 mce related protein; Region: MCE; pfam02470 1133849021883 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1133849021884 mce related protein; Region: MCE; pfam02470 1133849021885 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1133849021886 mce related protein; Region: MCE; pfam02470 1133849021887 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1133849021888 mce related protein; Region: MCE; pfam02470 1133849021889 mce related protein; Region: MCE; pfam02470 1133849021890 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1133849021891 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1133849021892 Permease; Region: Permease; pfam02405 1133849021893 Permease; Region: Permease; pfam02405 1133849021894 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1133849021895 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1133849021896 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1133849021897 putative substrate translocation pore; other site 1133849021898 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1133849021899 Beta-lactamase; Region: Beta-lactamase; pfam00144 1133849021900 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1133849021901 Cytochrome P450; Region: p450; cl12078 1133849021902 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1133849021903 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1133849021904 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1133849021905 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1133849021906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849021907 dimer interface [polypeptide binding]; other site 1133849021908 conserved gate region; other site 1133849021909 putative PBP binding loops; other site 1133849021910 ABC-ATPase subunit interface; other site 1133849021911 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1133849021912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1133849021913 dimer interface [polypeptide binding]; other site 1133849021914 conserved gate region; other site 1133849021915 putative PBP binding loops; other site 1133849021916 ABC-ATPase subunit interface; other site 1133849021917 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1133849021918 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1133849021919 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1133849021920 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1133849021921 Walker A/P-loop; other site 1133849021922 ATP binding site [chemical binding]; other site 1133849021923 Q-loop/lid; other site 1133849021924 ABC transporter signature motif; other site 1133849021925 Walker B; other site 1133849021926 D-loop; other site 1133849021927 H-loop/switch region; other site 1133849021928 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1133849021929 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1133849021930 active site 1133849021931 Zn binding site [ion binding]; other site 1133849021932 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1133849021933 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1133849021934 Pirin-related protein [General function prediction only]; Region: COG1741 1133849021935 Pirin; Region: Pirin; pfam02678 1133849021936 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1133849021937 active site 1133849021938 8-oxo-dGMP binding site [chemical binding]; other site 1133849021939 nudix motif; other site 1133849021940 metal binding site [ion binding]; metal-binding site 1133849021941 H+ Antiporter protein; Region: 2A0121; TIGR00900 1133849021942 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1133849021943 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1133849021944 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1133849021945 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1133849021946 putative active site [active] 1133849021947 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1133849021948 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1133849021949 active site 1133849021950 NTP binding site [chemical binding]; other site 1133849021951 metal binding triad [ion binding]; metal-binding site 1133849021952 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1133849021953 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1133849021954 Zn2+ binding site [ion binding]; other site 1133849021955 Mg2+ binding site [ion binding]; other site 1133849021956 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1133849021957 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1133849021958 active site 1133849021959 Ap6A binding site [chemical binding]; other site 1133849021960 nudix motif; other site 1133849021961 metal binding site [ion binding]; metal-binding site 1133849021962 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1133849021963 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1133849021964 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 1133849021965 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1133849021966 DNA binding residues [nucleotide binding] 1133849021967 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1133849021968 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1133849021969 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1133849021970 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1133849021971 catalytic residues [active] 1133849021972 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1133849021973 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1133849021974 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1133849021975 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1133849021976 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1133849021977 active site 1133849021978 metal binding site [ion binding]; metal-binding site 1133849021979 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1133849021980 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1133849021981 ParB-like nuclease domain; Region: ParBc; pfam02195 1133849021982 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1133849021983 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1133849021984 P-loop; other site 1133849021985 Magnesium ion binding site [ion binding]; other site 1133849021986 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1133849021987 Magnesium ion binding site [ion binding]; other site 1133849021988 FAD binding domain; Region: FAD_binding_3; pfam01494 1133849021989 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1133849021990 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1133849021991 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1133849021992 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1133849021993 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1133849021994 G-X-X-G motif; other site 1133849021995 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1133849021996 RxxxH motif; other site 1133849021997 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 1133849021998 hypothetical protein; Validated; Region: PRK00041 1133849021999 Ribonuclease P; Region: Ribonuclease_P; cl00457 1133849022000 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399