-- dump date 20140619_165007 -- class Genbank::misc_feature -- table misc_feature_note -- id note 247156000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 247156000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 247156000003 Walker A motif; other site 247156000004 ATP binding site [chemical binding]; other site 247156000005 Walker B motif; other site 247156000006 arginine finger; other site 247156000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 247156000008 DnaA box-binding interface [nucleotide binding]; other site 247156000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 247156000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 247156000011 putative DNA binding surface [nucleotide binding]; other site 247156000012 dimer interface [polypeptide binding]; other site 247156000013 beta-clamp/clamp loader binding surface; other site 247156000014 beta-clamp/translesion DNA polymerase binding surface; other site 247156000015 recombination protein F; Reviewed; Region: recF; PRK00064 247156000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 247156000017 Walker A/P-loop; other site 247156000018 ATP binding site [chemical binding]; other site 247156000019 Q-loop/lid; other site 247156000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156000021 ABC transporter signature motif; other site 247156000022 Walker B; other site 247156000023 D-loop; other site 247156000024 H-loop/switch region; other site 247156000025 hypothetical protein; Provisional; Region: PRK03195 247156000026 short chain dehydrogenase; Validated; Region: PRK05855 247156000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 247156000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 247156000029 ATP binding site [chemical binding]; other site 247156000030 Mg2+ binding site [ion binding]; other site 247156000031 G-X-G motif; other site 247156000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 247156000033 anchoring element; other site 247156000034 dimer interface [polypeptide binding]; other site 247156000035 ATP binding site [chemical binding]; other site 247156000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 247156000037 active site 247156000038 putative metal-binding site [ion binding]; other site 247156000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 247156000040 DNA gyrase subunit A; Validated; Region: PRK05560 247156000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 247156000042 CAP-like domain; other site 247156000043 active site 247156000044 primary dimer interface [polypeptide binding]; other site 247156000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 247156000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 247156000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 247156000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 247156000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 247156000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 247156000051 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 247156000052 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 247156000053 active site 247156000054 Int/Topo IB signature motif; other site 247156000055 DNA binding site [nucleotide binding] 247156000056 Helix-turn-helix domain; Region: HTH_17; cl17695 247156000057 ORF6N domain; Region: ORF6N; pfam10543 247156000058 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 247156000059 Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305 247156000060 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 247156000061 AAA domain; Region: AAA_25; pfam13481 247156000062 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 247156000063 active site 247156000064 Phage terminase, small subunit; Region: Terminase_4; cl01525 247156000065 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 247156000066 Phage-related protein [Function unknown]; Region: COG4695; cl01923 247156000067 Phage portal protein; Region: Phage_portal; pfam04860 247156000068 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 247156000069 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 247156000070 Phage capsid family; Region: Phage_capsid; pfam05065 247156000071 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 247156000072 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 247156000073 amidase catalytic site [active] 247156000074 Zn binding residues [ion binding]; other site 247156000075 substrate binding site [chemical binding]; other site 247156000076 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 247156000077 MYST -like histone acetyltransferase; Provisional; Region: PLN00104 247156000078 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 247156000079 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156000080 non-specific DNA binding site [nucleotide binding]; other site 247156000081 salt bridge; other site 247156000082 sequence-specific DNA binding site [nucleotide binding]; other site 247156000083 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156000084 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156000085 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156000086 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 247156000087 Walker A/P-loop; other site 247156000088 ATP binding site [chemical binding]; other site 247156000089 Q-loop/lid; other site 247156000090 ABC transporter signature motif; other site 247156000091 Walker B; other site 247156000092 D-loop; other site 247156000093 H-loop/switch region; other site 247156000094 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 247156000095 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 247156000096 Rhomboid family; Region: Rhomboid; pfam01694 247156000097 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 247156000098 putative septation inhibitor protein; Reviewed; Region: PRK00159 247156000099 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 247156000100 Glutamine amidotransferase class-I; Region: GATase; pfam00117 247156000101 glutamine binding [chemical binding]; other site 247156000102 catalytic triad [active] 247156000103 RibD C-terminal domain; Region: RibD_C; cl17279 247156000104 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 247156000105 catalytic motif [active] 247156000106 Zn binding site [ion binding]; other site 247156000107 FOG: CBS domain [General function prediction only]; Region: COG0517 247156000108 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 247156000109 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 247156000110 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 247156000111 active site 247156000112 ATP binding site [chemical binding]; other site 247156000113 substrate binding site [chemical binding]; other site 247156000114 activation loop (A-loop); other site 247156000115 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 247156000116 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 247156000117 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 247156000118 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 247156000119 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 247156000120 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 247156000121 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 247156000122 active site 247156000123 ATP binding site [chemical binding]; other site 247156000124 substrate binding site [chemical binding]; other site 247156000125 activation loop (A-loop); other site 247156000126 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 247156000127 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 247156000128 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 247156000129 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 247156000130 active site 247156000131 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 247156000132 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 247156000133 phosphopeptide binding site; other site 247156000134 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 247156000135 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 247156000136 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 247156000137 phosphopeptide binding site; other site 247156000138 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156000139 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156000140 WHG domain; Region: WHG; pfam13305 247156000141 MMPL family; Region: MMPL; pfam03176 247156000142 MMPL family; Region: MMPL; pfam03176 247156000143 Integral membrane protein DUF95; Region: DUF95; pfam01944 247156000144 Predicted membrane protein/domain [Function unknown]; Region: COG1714 247156000145 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 247156000146 Protein of unknown function DUF58; Region: DUF58; pfam01882 247156000147 MoxR-like ATPases [General function prediction only]; Region: COG0714 247156000148 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 247156000149 Walker A motif; other site 247156000150 ATP binding site [chemical binding]; other site 247156000151 Walker B motif; other site 247156000152 arginine finger; other site 247156000153 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 247156000154 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 247156000155 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 247156000156 active site 247156000157 dimer interface [polypeptide binding]; other site 247156000158 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 247156000159 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 247156000160 active site 247156000161 FMN binding site [chemical binding]; other site 247156000162 substrate binding site [chemical binding]; other site 247156000163 3Fe-4S cluster binding site [ion binding]; other site 247156000164 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 247156000165 domain interface; other site 247156000166 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 247156000167 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 247156000168 Cutinase; Region: Cutinase; pfam01083 247156000169 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 247156000170 catalytic core [active] 247156000171 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 247156000172 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 247156000173 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 247156000174 dimer interface [polypeptide binding]; other site 247156000175 putative anticodon binding site; other site 247156000176 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 247156000177 motif 1; other site 247156000178 dimer interface [polypeptide binding]; other site 247156000179 active site 247156000180 motif 2; other site 247156000181 motif 3; other site 247156000182 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 247156000183 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 247156000184 RNA binding surface [nucleotide binding]; other site 247156000185 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 247156000186 hydrophobic ligand binding site; other site 247156000187 CopC domain; Region: CopC; pfam04234 247156000188 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 247156000189 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 247156000190 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 247156000191 heat shock protein 90; Provisional; Region: PRK05218 247156000192 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 247156000193 ATP binding site [chemical binding]; other site 247156000194 Mg2+ binding site [ion binding]; other site 247156000195 G-X-G motif; other site 247156000196 Predicted membrane protein [Function unknown]; Region: COG2119 247156000197 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 247156000198 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 247156000199 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156000200 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156000201 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156000202 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 247156000203 NAD(P) binding site [chemical binding]; other site 247156000204 active site 247156000205 Methyltransferase domain; Region: Methyltransf_23; pfam13489 247156000206 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156000207 S-adenosylmethionine binding site [chemical binding]; other site 247156000208 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 247156000209 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 247156000210 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 247156000211 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 247156000212 active site residue [active] 247156000213 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 247156000214 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 247156000215 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 247156000216 putative active site [active] 247156000217 catalytic site [active] 247156000218 putative metal binding site [ion binding]; other site 247156000219 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 247156000220 Ferritin-like domain; Region: Ferritin; pfam00210 247156000221 ferroxidase diiron center [ion binding]; other site 247156000222 Ferritin-like domain; Region: Ferritin; pfam00210 247156000223 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 247156000224 dinuclear metal binding motif [ion binding]; other site 247156000225 Transcriptional regulator [Transcription]; Region: LytR; COG1316 247156000226 CAAX protease self-immunity; Region: Abi; pfam02517 247156000227 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 247156000228 prephenate dehydratase; Provisional; Region: PRK11898 247156000229 Prephenate dehydratase; Region: PDT; pfam00800 247156000230 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 247156000231 putative L-Phe binding site [chemical binding]; other site 247156000232 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 247156000233 catalytic core [active] 247156000234 EspG family; Region: ESX-1_EspG; pfam14011 247156000235 PE family; Region: PE; pfam00934 247156000236 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 247156000237 Septum formation; Region: Septum_form; pfam13845 247156000238 Septum formation; Region: Septum_form; pfam13845 247156000239 seryl-tRNA synthetase; Provisional; Region: PRK05431 247156000240 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 247156000241 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 247156000242 dimer interface [polypeptide binding]; other site 247156000243 active site 247156000244 motif 1; other site 247156000245 motif 2; other site 247156000246 motif 3; other site 247156000247 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 247156000248 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 247156000249 metal binding site [ion binding]; metal-binding site 247156000250 active site 247156000251 I-site; other site 247156000252 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 247156000253 Protein of unknown function, DUF606; Region: DUF606; pfam04657 247156000254 Protein of unknown function, DUF606; Region: DUF606; pfam04657 247156000255 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 247156000256 LysE type translocator; Region: LysE; cl00565 247156000257 LysE type translocator; Region: LysE; cl00565 247156000258 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 247156000259 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 247156000260 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 247156000261 dimerization interface [polypeptide binding]; other site 247156000262 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 247156000263 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 247156000264 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 247156000265 iron-sulfur cluster [ion binding]; other site 247156000266 [2Fe-2S] cluster binding site [ion binding]; other site 247156000267 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 247156000268 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 247156000269 putative acyl-acceptor binding pocket; other site 247156000270 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 247156000271 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 247156000272 putative acyl-acceptor binding pocket; other site 247156000273 thiamine pyrophosphate protein; Provisional; Region: PRK08273 247156000274 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 247156000275 PYR/PP interface [polypeptide binding]; other site 247156000276 dimer interface [polypeptide binding]; other site 247156000277 tetramer interface [polypeptide binding]; other site 247156000278 TPP binding site [chemical binding]; other site 247156000279 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 247156000280 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 247156000281 TPP-binding site [chemical binding]; other site 247156000282 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 247156000283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 247156000284 active site 247156000285 phosphorylation site [posttranslational modification] 247156000286 intermolecular recognition site; other site 247156000287 dimerization interface [polypeptide binding]; other site 247156000288 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 247156000289 CHASE3 domain; Region: CHASE3; pfam05227 247156000290 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 247156000291 dimer interface [polypeptide binding]; other site 247156000292 phosphorylation site [posttranslational modification] 247156000293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 247156000294 ATP binding site [chemical binding]; other site 247156000295 Mg2+ binding site [ion binding]; other site 247156000296 G-X-G motif; other site 247156000297 Response regulator receiver domain; Region: Response_reg; pfam00072 247156000298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 247156000299 active site 247156000300 phosphorylation site [posttranslational modification] 247156000301 intermolecular recognition site; other site 247156000302 dimerization interface [polypeptide binding]; other site 247156000303 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 247156000304 anti sigma factor interaction site; other site 247156000305 regulatory phosphorylation site [posttranslational modification]; other site 247156000306 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 247156000307 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 247156000308 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 247156000309 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 247156000310 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 247156000311 DNA binding residues [nucleotide binding] 247156000312 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 247156000313 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 247156000314 ATP binding site [chemical binding]; other site 247156000315 Mg2+ binding site [ion binding]; other site 247156000316 G-X-G motif; other site 247156000317 PAS fold; Region: PAS_3; pfam08447 247156000318 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 247156000319 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 247156000320 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 247156000321 metal-binding site [ion binding] 247156000322 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 247156000323 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 247156000324 Transcriptional regulators [Transcription]; Region: FadR; COG2186 247156000325 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 247156000326 DNA-binding site [nucleotide binding]; DNA binding site 247156000327 FCD domain; Region: FCD; cl11656 247156000328 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 247156000329 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 247156000330 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 247156000331 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 247156000332 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 247156000333 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 247156000334 Walker A/P-loop; other site 247156000335 ATP binding site [chemical binding]; other site 247156000336 Q-loop/lid; other site 247156000337 ABC transporter signature motif; other site 247156000338 Walker B; other site 247156000339 D-loop; other site 247156000340 H-loop/switch region; other site 247156000341 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 247156000342 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 247156000343 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 247156000344 Walker A/P-loop; other site 247156000345 ATP binding site [chemical binding]; other site 247156000346 Q-loop/lid; other site 247156000347 ABC transporter signature motif; other site 247156000348 Walker B; other site 247156000349 D-loop; other site 247156000350 H-loop/switch region; other site 247156000351 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 247156000352 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 247156000353 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 247156000354 dimer interface [polypeptide binding]; other site 247156000355 conserved gate region; other site 247156000356 putative PBP binding loops; other site 247156000357 ABC-ATPase subunit interface; other site 247156000358 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 247156000359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 247156000360 dimer interface [polypeptide binding]; other site 247156000361 conserved gate region; other site 247156000362 putative PBP binding loops; other site 247156000363 ABC-ATPase subunit interface; other site 247156000364 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 247156000365 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 247156000366 active site 247156000367 motif I; other site 247156000368 motif II; other site 247156000369 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 247156000370 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 247156000371 amidase catalytic site [active] 247156000372 Zn binding residues [ion binding]; other site 247156000373 substrate binding site [chemical binding]; other site 247156000374 Stage II sporulation protein; Region: SpoIID; pfam08486 247156000375 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 247156000376 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 247156000377 DNA binding residues [nucleotide binding] 247156000378 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 247156000379 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 247156000380 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 247156000381 UDP-galactopyranose mutase; Region: GLF; pfam03275 247156000382 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 247156000383 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 247156000384 active site 247156000385 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 247156000386 Predicted esterase [General function prediction only]; Region: COG0627 247156000387 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 247156000388 Predicted esterase [General function prediction only]; Region: COG0627 247156000389 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 247156000390 Predicted esterase [General function prediction only]; Region: COG0627 247156000391 Putative esterase; Region: Esterase; pfam00756 247156000392 S-formylglutathione hydrolase; Region: PLN02442 247156000393 LGFP repeat; Region: LGFP; pfam08310 247156000394 LGFP repeat; Region: LGFP; pfam08310 247156000395 LGFP repeat; Region: LGFP; pfam08310 247156000396 Protein of unknown function (DUF732); Region: DUF732; pfam05305 247156000397 Cutinase; Region: Cutinase; pfam01083 247156000398 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 247156000399 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 247156000400 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 247156000401 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 247156000402 acyl-activating enzyme (AAE) consensus motif; other site 247156000403 active site 247156000404 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 247156000405 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 247156000406 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 247156000407 active site 247156000408 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 247156000409 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 247156000410 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 247156000411 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 247156000412 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 247156000413 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 247156000414 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 247156000415 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 247156000416 substrate binding site [chemical binding]; other site 247156000417 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 247156000418 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 247156000419 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 247156000420 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 247156000421 short chain dehydrogenase; Provisional; Region: PRK07904 247156000422 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 247156000423 NAD(P) binding site [chemical binding]; other site 247156000424 active site 247156000425 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 247156000426 FAD binding domain; Region: FAD_binding_4; pfam01565 247156000427 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 247156000428 Predicted membrane protein [Function unknown]; Region: COG2246 247156000429 GtrA-like protein; Region: GtrA; pfam04138 247156000430 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 247156000431 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 247156000432 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 247156000433 putative [Fe4-S4] binding site [ion binding]; other site 247156000434 putative molybdopterin cofactor binding site [chemical binding]; other site 247156000435 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 247156000436 putative molybdopterin cofactor binding site; other site 247156000437 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 247156000438 Helix-turn-helix domain; Region: HTH_31; pfam13560 247156000439 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 247156000440 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 247156000441 putative DNA binding site [nucleotide binding]; other site 247156000442 putative Zn2+ binding site [ion binding]; other site 247156000443 Major Facilitator Superfamily; Region: MFS_1; pfam07690 247156000444 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 247156000445 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 247156000446 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 247156000447 substrate binding site; other site 247156000448 tetramer interface; other site 247156000449 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 247156000450 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 247156000451 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 247156000452 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 247156000453 NAD binding site [chemical binding]; other site 247156000454 substrate binding site [chemical binding]; other site 247156000455 homodimer interface [polypeptide binding]; other site 247156000456 active site 247156000457 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 247156000458 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 247156000459 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 247156000460 Ligand binding site; other site 247156000461 Putative Catalytic site; other site 247156000462 DXD motif; other site 247156000463 Predicted membrane protein [Function unknown]; Region: COG2246 247156000464 GtrA-like protein; Region: GtrA; pfam04138 247156000465 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 247156000466 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 247156000467 active site 247156000468 short chain dehydrogenase; Provisional; Region: PRK08278 247156000469 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156000470 NAD(P) binding site [chemical binding]; other site 247156000471 active site 247156000472 GTPase RsgA; Reviewed; Region: PRK01889 247156000473 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 247156000474 GTPase/Zn-binding domain interface [polypeptide binding]; other site 247156000475 GTP/Mg2+ binding site [chemical binding]; other site 247156000476 G4 box; other site 247156000477 G5 box; other site 247156000478 G1 box; other site 247156000479 Switch I region; other site 247156000480 G2 box; other site 247156000481 G3 box; other site 247156000482 Switch II region; other site 247156000483 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 247156000484 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 247156000485 active site 247156000486 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 247156000487 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 247156000488 Walker A/P-loop; other site 247156000489 ATP binding site [chemical binding]; other site 247156000490 Q-loop/lid; other site 247156000491 ABC transporter signature motif; other site 247156000492 Walker B; other site 247156000493 D-loop; other site 247156000494 H-loop/switch region; other site 247156000495 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 247156000496 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 247156000497 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 247156000498 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 247156000499 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 247156000500 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 247156000501 catalytic residue [active] 247156000502 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 247156000503 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 247156000504 NAD(P) binding site [chemical binding]; other site 247156000505 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 247156000506 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 247156000507 putative active site [active] 247156000508 putative substrate binding site [chemical binding]; other site 247156000509 putative FMN binding site [chemical binding]; other site 247156000510 putative catalytic residues [active] 247156000511 MarR family; Region: MarR_2; cl17246 247156000512 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 247156000513 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 247156000514 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 247156000515 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 247156000516 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 247156000517 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 247156000518 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 247156000519 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156000520 homodimer interface [polypeptide binding]; other site 247156000521 catalytic residue [active] 247156000522 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 247156000523 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 247156000524 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 247156000525 homotrimer interaction site [polypeptide binding]; other site 247156000526 putative active site [active] 247156000527 Protein of unknown function (DUF998); Region: DUF998; pfam06197 247156000528 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 247156000529 additional DNA contacts [nucleotide binding]; other site 247156000530 mismatch recognition site; other site 247156000531 active site 247156000532 zinc binding site [ion binding]; other site 247156000533 DNA intercalation site [nucleotide binding]; other site 247156000534 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 247156000535 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 247156000536 cofactor binding site; other site 247156000537 DNA binding site [nucleotide binding] 247156000538 substrate interaction site [chemical binding]; other site 247156000539 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 247156000540 prephenate dehydrogenase; Validated; Region: PRK06545 247156000541 prephenate dehydrogenase; Validated; Region: PRK08507 247156000542 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 247156000543 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 247156000544 nucleoside/Zn binding site; other site 247156000545 dimer interface [polypeptide binding]; other site 247156000546 catalytic motif [active] 247156000547 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 247156000548 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 247156000549 active site 247156000550 DNA binding site [nucleotide binding] 247156000551 Int/Topo IB signature motif; other site 247156000552 Helix-turn-helix domain; Region: HTH_17; pfam12728 247156000553 AAA domain; Region: AAA_25; pfam13481 247156000554 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 247156000555 Walker A motif; other site 247156000556 ATP binding site [chemical binding]; other site 247156000557 Walker B motif; other site 247156000558 Helix-turn-helix domain; Region: HTH_17; cl17695 247156000559 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 247156000560 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 247156000561 active site 247156000562 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 247156000563 Phage capsid family; Region: Phage_capsid; pfam05065 247156000564 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156000565 non-specific DNA binding site [nucleotide binding]; other site 247156000566 salt bridge; other site 247156000567 sequence-specific DNA binding site [nucleotide binding]; other site 247156000568 Immunoglobulin domain; Region: Ig; cl11960 247156000569 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156000570 non-specific DNA binding site [nucleotide binding]; other site 247156000571 salt bridge; other site 247156000572 sequence-specific DNA binding site [nucleotide binding]; other site 247156000573 MMPL family; Region: MMPL; pfam03176 247156000574 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 247156000575 MMPL family; Region: MMPL; pfam03176 247156000576 Protein export membrane protein; Region: SecD_SecF; cl14618 247156000577 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156000578 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156000579 Predicted transcriptional regulator [Transcription]; Region: COG1959 247156000580 Transcriptional regulator; Region: Rrf2; pfam02082 247156000581 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 247156000582 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 247156000583 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156000584 Walker A/P-loop; other site 247156000585 ATP binding site [chemical binding]; other site 247156000586 Q-loop/lid; other site 247156000587 ABC transporter signature motif; other site 247156000588 Walker B; other site 247156000589 D-loop; other site 247156000590 H-loop/switch region; other site 247156000591 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 247156000592 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 247156000593 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 247156000594 Walker A/P-loop; other site 247156000595 ATP binding site [chemical binding]; other site 247156000596 Q-loop/lid; other site 247156000597 ABC transporter signature motif; other site 247156000598 Walker B; other site 247156000599 D-loop; other site 247156000600 H-loop/switch region; other site 247156000601 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 247156000602 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 247156000603 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 247156000604 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 247156000605 RDD family; Region: RDD; pfam06271 247156000606 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 247156000607 active site 247156000608 HIGH motif; other site 247156000609 nucleotide binding site [chemical binding]; other site 247156000610 active site 247156000611 KMSKS motif; other site 247156000612 Domain of unknown function (DUF309); Region: DUF309; pfam03745 247156000613 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 247156000614 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 247156000615 putative acyl-acceptor binding pocket; other site 247156000616 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 247156000617 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 247156000618 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156000619 homodimer interface [polypeptide binding]; other site 247156000620 catalytic residue [active] 247156000621 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 247156000622 putative hydrophobic ligand binding site [chemical binding]; other site 247156000623 hypothetical protein; Provisional; Region: PRK08317 247156000624 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156000625 S-adenosylmethionine binding site [chemical binding]; other site 247156000626 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 247156000627 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 247156000628 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 247156000629 uncharacterized HhH-GPD family protein; Region: TIGR03252 247156000630 minor groove reading motif; other site 247156000631 helix-hairpin-helix signature motif; other site 247156000632 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 247156000633 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 247156000634 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 247156000635 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 247156000636 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 247156000637 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 247156000638 Walker A motif; other site 247156000639 ATP binding site [chemical binding]; other site 247156000640 Walker B motif; other site 247156000641 arginine finger; other site 247156000642 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 247156000643 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 247156000644 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 247156000645 dimer interface [polypeptide binding]; other site 247156000646 active site 247156000647 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 247156000648 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 247156000649 substrate binding site [chemical binding]; other site 247156000650 oxyanion hole (OAH) forming residues; other site 247156000651 trimer interface [polypeptide binding]; other site 247156000652 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 247156000653 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 247156000654 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 247156000655 Catalytic domain of Protein Kinases; Region: PKc; cd00180 247156000656 active site 247156000657 ATP binding site [chemical binding]; other site 247156000658 substrate binding site [chemical binding]; other site 247156000659 activation loop (A-loop); other site 247156000660 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 247156000661 AAA ATPase domain; Region: AAA_16; pfam13191 247156000662 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 247156000663 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156000664 S-adenosylmethionine binding site [chemical binding]; other site 247156000665 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 247156000666 FAD binding domain; Region: FAD_binding_4; pfam01565 247156000667 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 247156000668 hydrophobic ligand binding site; other site 247156000669 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 247156000670 active site 247156000671 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 247156000672 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 247156000673 DNA binding residues [nucleotide binding] 247156000674 drug binding residues [chemical binding]; other site 247156000675 dimer interface [polypeptide binding]; other site 247156000676 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 247156000677 hypothetical protein; Validated; Region: PRK00153 247156000678 recombination protein RecR; Reviewed; Region: recR; PRK00076 247156000679 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 247156000680 RecR protein; Region: RecR; pfam02132 247156000681 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 247156000682 putative active site [active] 247156000683 putative metal-binding site [ion binding]; other site 247156000684 tetramer interface [polypeptide binding]; other site 247156000685 DEAD-like helicases superfamily; Region: DEXDc; smart00487 247156000686 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 247156000687 ATP binding site [chemical binding]; other site 247156000688 putative Mg++ binding site [ion binding]; other site 247156000689 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 247156000690 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 247156000691 nucleotide binding region [chemical binding]; other site 247156000692 ATP-binding site [chemical binding]; other site 247156000693 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 247156000694 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 247156000695 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 247156000696 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 247156000697 catalytic triad [active] 247156000698 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 247156000699 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 247156000700 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 247156000701 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 247156000702 Uncharacterized conserved protein [Function unknown]; Region: COG3349 247156000703 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 247156000704 EamA-like transporter family; Region: EamA; cl17759 247156000705 Transcriptional regulator [Transcription]; Region: LysR; COG0583 247156000706 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 247156000707 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 247156000708 putative dimerization interface [polypeptide binding]; other site 247156000709 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 247156000710 2-isopropylmalate synthase; Validated; Region: PRK03739 247156000711 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 247156000712 active site 247156000713 catalytic residues [active] 247156000714 metal binding site [ion binding]; metal-binding site 247156000715 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 247156000716 hypothetical protein; Provisional; Region: PRK10621 247156000717 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 247156000718 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 247156000719 TAP-like protein; Region: Abhydrolase_4; pfam08386 247156000720 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 247156000721 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 247156000722 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 247156000723 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 247156000724 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 247156000725 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 247156000726 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 247156000727 putative hydrophobic ligand binding site [chemical binding]; other site 247156000728 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156000729 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156000730 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 247156000731 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 247156000732 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 247156000733 NADP+ binding site [chemical binding]; other site 247156000734 folate binding site [chemical binding]; other site 247156000735 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 247156000736 aspartate kinase; Reviewed; Region: PRK06635 247156000737 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 247156000738 putative nucleotide binding site [chemical binding]; other site 247156000739 putative catalytic residues [active] 247156000740 putative Mg ion binding site [ion binding]; other site 247156000741 putative aspartate binding site [chemical binding]; other site 247156000742 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 247156000743 putative allosteric regulatory site; other site 247156000744 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 247156000745 putative allosteric regulatory residue; other site 247156000746 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 247156000747 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 247156000748 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 247156000749 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 247156000750 homodimer interface [polypeptide binding]; other site 247156000751 substrate-cofactor binding pocket; other site 247156000752 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156000753 catalytic residue [active] 247156000754 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 247156000755 Beta-lactamase; Region: Beta-lactamase; pfam00144 247156000756 amino acid transporter; Region: 2A0306; TIGR00909 247156000757 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 247156000758 metal binding site 2 [ion binding]; metal-binding site 247156000759 putative DNA binding helix; other site 247156000760 metal binding site 1 [ion binding]; metal-binding site 247156000761 dimer interface [polypeptide binding]; other site 247156000762 structural Zn2+ binding site [ion binding]; other site 247156000763 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 247156000764 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 247156000765 active site 247156000766 catalytic tetrad [active] 247156000767 Helix-turn-helix domain; Region: HTH_31; pfam13560 247156000768 non-specific DNA binding site [nucleotide binding]; other site 247156000769 salt bridge; other site 247156000770 sequence-specific DNA binding site [nucleotide binding]; other site 247156000771 Domain of unknown function (DUF397); Region: DUF397; pfam04149 247156000772 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 247156000773 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 247156000774 putative active site [active] 247156000775 putative metal binding site [ion binding]; other site 247156000776 Yqey-like protein; Region: YqeY; pfam09424 247156000777 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 247156000778 Transglycosylase; Region: Transgly; pfam00912 247156000779 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 247156000780 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 247156000781 Transcription factor WhiB; Region: Whib; pfam02467 247156000782 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 247156000783 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 247156000784 DTAP/Switch II; other site 247156000785 Switch I; other site 247156000786 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 247156000787 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 247156000788 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 247156000789 P loop; other site 247156000790 Nucleotide binding site [chemical binding]; other site 247156000791 DTAP/Switch II; other site 247156000792 Switch I; other site 247156000793 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 247156000794 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 247156000795 homotrimer interaction site [polypeptide binding]; other site 247156000796 putative active site [active] 247156000797 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 247156000798 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 247156000799 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 247156000800 ligand binding site [chemical binding]; other site 247156000801 flexible hinge region; other site 247156000802 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 247156000803 putative switch regulator; other site 247156000804 non-specific DNA interactions [nucleotide binding]; other site 247156000805 DNA binding site [nucleotide binding] 247156000806 sequence specific DNA binding site [nucleotide binding]; other site 247156000807 putative cAMP binding site [chemical binding]; other site 247156000808 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 247156000809 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 247156000810 minor groove reading motif; other site 247156000811 helix-hairpin-helix signature motif; other site 247156000812 substrate binding pocket [chemical binding]; other site 247156000813 active site 247156000814 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 247156000815 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 247156000816 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 247156000817 catalytic residues [active] 247156000818 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 247156000819 putative active site [active] 247156000820 putative CoA binding site [chemical binding]; other site 247156000821 nudix motif; other site 247156000822 metal binding site [ion binding]; metal-binding site 247156000823 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 247156000824 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 247156000825 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 247156000826 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 247156000827 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 247156000828 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 247156000829 acetyl-CoA synthetase; Provisional; Region: PRK00174 247156000830 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 247156000831 active site 247156000832 CoA binding site [chemical binding]; other site 247156000833 acyl-activating enzyme (AAE) consensus motif; other site 247156000834 AMP binding site [chemical binding]; other site 247156000835 acetate binding site [chemical binding]; other site 247156000836 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 247156000837 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 247156000838 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 247156000839 Type II/IV secretion system protein; Region: T2SE; pfam00437 247156000840 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 247156000841 hexamer interface [polypeptide binding]; other site 247156000842 Walker B motif; other site 247156000843 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 247156000844 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 247156000845 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 247156000846 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 247156000847 ATP binding site [chemical binding]; other site 247156000848 putative Mg++ binding site [ion binding]; other site 247156000849 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 247156000850 nucleotide binding region [chemical binding]; other site 247156000851 ATP-binding site [chemical binding]; other site 247156000852 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 247156000853 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 247156000854 DNA-binding site [nucleotide binding]; DNA binding site 247156000855 RNA-binding motif; other site 247156000856 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 247156000857 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 247156000858 active site 247156000859 interdomain interaction site; other site 247156000860 putative metal-binding site [ion binding]; other site 247156000861 nucleotide binding site [chemical binding]; other site 247156000862 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 247156000863 domain I; other site 247156000864 phosphate binding site [ion binding]; other site 247156000865 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 247156000866 domain II; other site 247156000867 domain III; other site 247156000868 nucleotide binding site [chemical binding]; other site 247156000869 DNA binding groove [nucleotide binding] 247156000870 catalytic site [active] 247156000871 domain IV; other site 247156000872 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 247156000873 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 247156000874 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 247156000875 DNA polymerase III subunit delta'; Validated; Region: PRK07940 247156000876 DNA polymerase III subunit delta'; Validated; Region: PRK08485 247156000877 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 247156000878 RibD C-terminal domain; Region: RibD_C; cl17279 247156000879 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 247156000880 Protein of unknown function (DUF419); Region: DUF419; pfam04237 247156000881 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 247156000882 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 247156000883 DNA-binding site [nucleotide binding]; DNA binding site 247156000884 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 247156000885 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 247156000886 Walker A/P-loop; other site 247156000887 ATP binding site [chemical binding]; other site 247156000888 Q-loop/lid; other site 247156000889 ABC transporter signature motif; other site 247156000890 Walker B; other site 247156000891 D-loop; other site 247156000892 H-loop/switch region; other site 247156000893 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 247156000894 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 247156000895 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 247156000896 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 247156000897 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 247156000898 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 247156000899 Zn binding site [ion binding]; other site 247156000900 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 247156000901 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 247156000902 acyl-activating enzyme (AAE) consensus motif; other site 247156000903 AMP binding site [chemical binding]; other site 247156000904 active site 247156000905 CoA binding site [chemical binding]; other site 247156000906 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156000907 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 247156000908 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 247156000909 putative trimer interface [polypeptide binding]; other site 247156000910 putative CoA binding site [chemical binding]; other site 247156000911 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 247156000912 putative trimer interface [polypeptide binding]; other site 247156000913 putative CoA binding site [chemical binding]; other site 247156000914 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 247156000915 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 247156000916 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 247156000917 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 247156000918 catalytic residue [active] 247156000919 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 247156000920 enoyl-CoA hydratase; Provisional; Region: PRK06142 247156000921 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 247156000922 substrate binding site [chemical binding]; other site 247156000923 oxyanion hole (OAH) forming residues; other site 247156000924 trimer interface [polypeptide binding]; other site 247156000925 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 247156000926 dimer interface [polypeptide binding]; other site 247156000927 substrate binding site [chemical binding]; other site 247156000928 metal binding sites [ion binding]; metal-binding site 247156000929 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 247156000930 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 247156000931 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 247156000932 putative hydrolase; Region: TIGR03624 247156000933 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 247156000934 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 247156000935 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 247156000936 active site 247156000937 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 247156000938 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 247156000939 active site 247156000940 ATP binding site [chemical binding]; other site 247156000941 substrate binding site [chemical binding]; other site 247156000942 activation loop (A-loop); other site 247156000943 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 247156000944 Catalytic domain of Protein Kinases; Region: PKc; cd00180 247156000945 active site 247156000946 ATP binding site [chemical binding]; other site 247156000947 substrate binding site [chemical binding]; other site 247156000948 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 247156000949 substrate binding site [chemical binding]; other site 247156000950 activation loop (A-loop); other site 247156000951 activation loop (A-loop); other site 247156000952 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 247156000953 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 247156000954 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 247156000955 dimerization interface [polypeptide binding]; other site 247156000956 substrate binding pocket [chemical binding]; other site 247156000957 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 247156000958 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 247156000959 NAD(P) binding site [chemical binding]; other site 247156000960 catalytic residues [active] 247156000961 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 247156000962 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 247156000963 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 247156000964 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 247156000965 FtsH Extracellular; Region: FtsH_ext; pfam06480 247156000966 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 247156000967 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 247156000968 Walker A motif; other site 247156000969 ATP binding site [chemical binding]; other site 247156000970 Walker B motif; other site 247156000971 arginine finger; other site 247156000972 Peptidase family M41; Region: Peptidase_M41; pfam01434 247156000973 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 247156000974 homodecamer interface [polypeptide binding]; other site 247156000975 GTP cyclohydrolase I; Provisional; Region: PLN03044 247156000976 active site 247156000977 putative catalytic site residues [active] 247156000978 zinc binding site [ion binding]; other site 247156000979 GTP-CH-I/GFRP interaction surface; other site 247156000980 dihydropteroate synthase; Region: DHPS; TIGR01496 247156000981 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 247156000982 substrate binding pocket [chemical binding]; other site 247156000983 dimer interface [polypeptide binding]; other site 247156000984 inhibitor binding site; inhibition site 247156000985 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 247156000986 homooctamer interface [polypeptide binding]; other site 247156000987 active site 247156000988 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 247156000989 catalytic center binding site [active] 247156000990 ATP binding site [chemical binding]; other site 247156000991 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 247156000992 Rossmann-like domain; Region: Rossmann-like; pfam10727 247156000993 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 247156000994 pantoate--beta-alanine ligase; Region: panC; TIGR00018 247156000995 Pantoate-beta-alanine ligase; Region: PanC; cd00560 247156000996 active site 247156000997 ATP-binding site [chemical binding]; other site 247156000998 pantoate-binding site; other site 247156000999 HXXH motif; other site 247156001000 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 247156001001 tetramerization interface [polypeptide binding]; other site 247156001002 active site 247156001003 pantothenate kinase; Reviewed; Region: PRK13318 247156001004 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 247156001005 Rhodanese Homology Domain; Region: RHOD; smart00450 247156001006 active site residue [active] 247156001007 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 247156001008 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 247156001009 dimer interface [polypeptide binding]; other site 247156001010 putative anticodon binding site; other site 247156001011 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 247156001012 motif 1; other site 247156001013 dimer interface [polypeptide binding]; other site 247156001014 active site 247156001015 motif 2; other site 247156001016 motif 3; other site 247156001017 Lsr2; Region: Lsr2; pfam11774 247156001018 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 247156001019 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 247156001020 phosphopeptide binding site; other site 247156001021 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 247156001022 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 247156001023 DNA binding residues [nucleotide binding] 247156001024 dimerization interface [polypeptide binding]; other site 247156001025 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 247156001026 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 247156001027 Clp amino terminal domain; Region: Clp_N; pfam02861 247156001028 Clp amino terminal domain; Region: Clp_N; pfam02861 247156001029 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 247156001030 Walker A motif; other site 247156001031 ATP binding site [chemical binding]; other site 247156001032 Walker B motif; other site 247156001033 arginine finger; other site 247156001034 UvrB/uvrC motif; Region: UVR; pfam02151 247156001035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 247156001036 Walker A motif; other site 247156001037 ATP binding site [chemical binding]; other site 247156001038 Walker B motif; other site 247156001039 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 247156001040 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156001041 non-specific DNA binding site [nucleotide binding]; other site 247156001042 salt bridge; other site 247156001043 sequence-specific DNA binding site [nucleotide binding]; other site 247156001044 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 247156001045 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 247156001046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 247156001047 active site 247156001048 phosphorylation site [posttranslational modification] 247156001049 intermolecular recognition site; other site 247156001050 dimerization interface [polypeptide binding]; other site 247156001051 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 247156001052 DNA binding residues [nucleotide binding] 247156001053 dimerization interface [polypeptide binding]; other site 247156001054 Histidine kinase; Region: HisKA_3; pfam07730 247156001055 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 247156001056 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 247156001057 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 247156001058 Walker A/P-loop; other site 247156001059 ATP binding site [chemical binding]; other site 247156001060 Q-loop/lid; other site 247156001061 ABC transporter signature motif; other site 247156001062 Walker B; other site 247156001063 D-loop; other site 247156001064 H-loop/switch region; other site 247156001065 Histidine kinase; Region: HisKA_3; pfam07730 247156001066 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 247156001067 ATP binding site [chemical binding]; other site 247156001068 Mg2+ binding site [ion binding]; other site 247156001069 G-X-G motif; other site 247156001070 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 247156001071 putative hydrophobic ligand binding site [chemical binding]; other site 247156001072 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 247156001073 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 247156001074 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 247156001075 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 247156001076 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 247156001077 catalytic site [active] 247156001078 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 247156001079 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 247156001080 minor groove reading motif; other site 247156001081 helix-hairpin-helix signature motif; other site 247156001082 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 247156001083 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 247156001084 active site clefts [active] 247156001085 zinc binding site [ion binding]; other site 247156001086 dimer interface [polypeptide binding]; other site 247156001087 DNA repair protein RadA; Provisional; Region: PRK11823 247156001088 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 247156001089 Walker A motif; other site 247156001090 ATP binding site [chemical binding]; other site 247156001091 Walker B motif; other site 247156001092 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 247156001093 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 247156001094 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 247156001095 substrate binding site; other site 247156001096 dimer interface; other site 247156001097 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 247156001098 homotrimer interaction site [polypeptide binding]; other site 247156001099 zinc binding site [ion binding]; other site 247156001100 CDP-binding sites; other site 247156001101 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 247156001102 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 247156001103 active site 247156001104 HIGH motif; other site 247156001105 nucleotide binding site [chemical binding]; other site 247156001106 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 247156001107 KMSKS motif; other site 247156001108 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 247156001109 tRNA binding surface [nucleotide binding]; other site 247156001110 anticodon binding site; other site 247156001111 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 247156001112 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 247156001113 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 247156001114 enoyl-CoA hydratase; Provisional; Region: PRK08260 247156001115 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 247156001116 substrate binding site [chemical binding]; other site 247156001117 oxyanion hole (OAH) forming residues; other site 247156001118 trimer interface [polypeptide binding]; other site 247156001119 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156001120 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 247156001121 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 247156001122 active site 247156001123 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 247156001124 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 247156001125 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156001126 Walker A/P-loop; other site 247156001127 ATP binding site [chemical binding]; other site 247156001128 Q-loop/lid; other site 247156001129 ABC transporter signature motif; other site 247156001130 Walker B; other site 247156001131 D-loop; other site 247156001132 H-loop/switch region; other site 247156001133 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 247156001134 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 247156001135 intersubunit interface [polypeptide binding]; other site 247156001136 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 247156001137 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 247156001138 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 247156001139 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 247156001140 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156001141 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156001142 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156001143 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156001144 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156001145 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156001146 active site 247156001147 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156001148 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 247156001149 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156001150 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156001151 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156001152 active site 247156001153 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 247156001154 active site 247156001155 catalytic site [active] 247156001156 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 247156001157 DUF35 OB-fold domain; Region: DUF35; pfam01796 247156001158 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 247156001159 putative active site [active] 247156001160 putative catalytic site [active] 247156001161 lipid-transfer protein; Provisional; Region: PRK07855 247156001162 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 247156001163 active site 247156001164 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683 247156001165 nudix motif; other site 247156001166 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156001167 Predicted ATPase [General function prediction only]; Region: COG1485 247156001168 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 247156001169 MoxR-like ATPases [General function prediction only]; Region: COG0714 247156001170 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 247156001171 Walker A motif; other site 247156001172 ATP binding site [chemical binding]; other site 247156001173 Walker B motif; other site 247156001174 arginine finger; other site 247156001175 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 247156001176 Protein of unknown function DUF58; Region: DUF58; pfam01882 247156001177 enoyl-CoA hydratase; Region: PLN02864 247156001178 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 247156001179 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 247156001180 dimer interaction site [polypeptide binding]; other site 247156001181 substrate-binding tunnel; other site 247156001182 active site 247156001183 catalytic site [active] 247156001184 substrate binding site [chemical binding]; other site 247156001185 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 247156001186 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 247156001187 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 247156001188 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 247156001189 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 247156001190 acetaldehyde dehydrogenase; Validated; Region: PRK08300 247156001191 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 247156001192 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 247156001193 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 247156001194 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 247156001195 active site 247156001196 catalytic residues [active] 247156001197 metal binding site [ion binding]; metal-binding site 247156001198 DmpG-like communication domain; Region: DmpG_comm; pfam07836 247156001199 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 247156001200 dimerization interface [polypeptide binding]; other site 247156001201 putative DNA binding site [nucleotide binding]; other site 247156001202 putative Zn2+ binding site [ion binding]; other site 247156001203 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 247156001204 putative hydrophobic ligand binding site [chemical binding]; other site 247156001205 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 247156001206 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 247156001207 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 247156001208 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 247156001209 active site 247156001210 Fe binding site [ion binding]; other site 247156001211 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 247156001212 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 247156001213 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 247156001214 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156001215 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 247156001216 Flavin binding site [chemical binding]; other site 247156001217 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 247156001218 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 247156001219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156001220 Major Facilitator Superfamily; Region: MFS_1; pfam07690 247156001221 putative substrate translocation pore; other site 247156001222 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 247156001223 MarR family; Region: MarR_2; pfam12802 247156001224 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 247156001225 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 247156001226 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156001227 active site 247156001228 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156001229 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 247156001230 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156001231 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156001232 active site 247156001233 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156001234 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156001235 active site 247156001236 enoyl-CoA hydratase; Provisional; Region: PRK08290 247156001237 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 247156001238 substrate binding site [chemical binding]; other site 247156001239 oxyanion hole (OAH) forming residues; other site 247156001240 trimer interface [polypeptide binding]; other site 247156001241 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 247156001242 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 247156001243 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 247156001244 acyl-activating enzyme (AAE) consensus motif; other site 247156001245 putative AMP binding site [chemical binding]; other site 247156001246 putative active site [active] 247156001247 putative CoA binding site [chemical binding]; other site 247156001248 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 247156001249 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156001250 active site 247156001251 short chain dehydrogenase; Provisional; Region: PRK07831 247156001252 classical (c) SDRs; Region: SDR_c; cd05233 247156001253 NAD(P) binding site [chemical binding]; other site 247156001254 active site 247156001255 Proteins of 100 residues with WXG; Region: WXG100; cl02005 247156001256 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156001257 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156001258 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 247156001259 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 247156001260 dimer interface [polypeptide binding]; other site 247156001261 active site 247156001262 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 247156001263 RNA binding site [nucleotide binding]; other site 247156001264 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 247156001265 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 247156001266 motif II; other site 247156001267 Domain of unknown function (DUF397); Region: DUF397; pfam04149 247156001268 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 247156001269 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 247156001270 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 247156001271 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 247156001272 SnoaL-like domain; Region: SnoaL_2; pfam12680 247156001273 Beta-lactamase; Region: Beta-lactamase; pfam00144 247156001274 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 247156001275 DoxX-like family; Region: DoxX_2; pfam13564 247156001276 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 247156001277 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 247156001278 active site 247156001279 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 247156001280 non-prolyl cis peptide bond; other site 247156001281 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156001282 salt bridge; other site 247156001283 non-specific DNA binding site [nucleotide binding]; other site 247156001284 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 247156001285 sequence-specific DNA binding site [nucleotide binding]; other site 247156001286 short chain dehydrogenase; Provisional; Region: PRK12939 247156001287 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 247156001288 NADP binding site [chemical binding]; other site 247156001289 substrate binding site [chemical binding]; other site 247156001290 active site 247156001291 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 247156001292 Isochorismatase family; Region: Isochorismatase; pfam00857 247156001293 catalytic triad [active] 247156001294 conserved cis-peptide bond; other site 247156001295 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 247156001296 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 247156001297 conserved cys residue [active] 247156001298 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 247156001299 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 247156001300 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 247156001301 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 247156001302 Nitronate monooxygenase; Region: NMO; pfam03060 247156001303 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 247156001304 FMN binding site [chemical binding]; other site 247156001305 substrate binding site [chemical binding]; other site 247156001306 putative catalytic residue [active] 247156001307 Coenzyme A transferase; Region: CoA_trans; cl17247 247156001308 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 247156001309 enoyl-CoA hydratase; Provisional; Region: PRK06495 247156001310 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 247156001311 substrate binding site [chemical binding]; other site 247156001312 oxyanion hole (OAH) forming residues; other site 247156001313 trimer interface [polypeptide binding]; other site 247156001314 short chain dehydrogenase; Provisional; Region: PRK07856 247156001315 classical (c) SDRs; Region: SDR_c; cd05233 247156001316 NAD(P) binding site [chemical binding]; other site 247156001317 active site 247156001318 short chain dehydrogenase; Provisional; Region: PRK07791 247156001319 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 247156001320 NAD binding site [chemical binding]; other site 247156001321 homodimer interface [polypeptide binding]; other site 247156001322 active site 247156001323 Domain of unknown function (DUF955); Region: DUF955; cl01076 247156001324 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 247156001325 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156001326 sequence-specific DNA binding site [nucleotide binding]; other site 247156001327 salt bridge; other site 247156001328 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 247156001329 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 247156001330 dimer interface [polypeptide binding]; other site 247156001331 active site 247156001332 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 247156001333 Cytochrome P450; Region: p450; cl12078 247156001334 SnoaL-like domain; Region: SnoaL_2; pfam12680 247156001335 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 247156001336 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 247156001337 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 247156001338 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 247156001339 active site 247156001340 lipid-transfer protein; Provisional; Region: PRK07937 247156001341 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 247156001342 active site 247156001343 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 247156001344 DUF35 OB-fold domain; Region: DUF35; pfam01796 247156001345 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 247156001346 DUF35 OB-fold domain; Region: DUF35; pfam01796 247156001347 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 247156001348 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 247156001349 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 247156001350 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 247156001351 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 247156001352 acyl-activating enzyme (AAE) consensus motif; other site 247156001353 acyl-activating enzyme (AAE) consensus motif; other site 247156001354 putative AMP binding site [chemical binding]; other site 247156001355 putative active site [active] 247156001356 putative CoA binding site [chemical binding]; other site 247156001357 RNA polymerase factor sigma-70; Validated; Region: PRK08241 247156001358 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 247156001359 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 247156001360 DNA binding residues [nucleotide binding] 247156001361 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 247156001362 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 247156001363 enoyl-CoA hydratase; Provisional; Region: PRK07799 247156001364 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 247156001365 substrate binding site [chemical binding]; other site 247156001366 oxyanion hole (OAH) forming residues; other site 247156001367 trimer interface [polypeptide binding]; other site 247156001368 acyl-CoA synthetase; Validated; Region: PRK07798 247156001369 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 247156001370 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 247156001371 acyl-activating enzyme (AAE) consensus motif; other site 247156001372 acyl-activating enzyme (AAE) consensus motif; other site 247156001373 putative AMP binding site [chemical binding]; other site 247156001374 putative active site [active] 247156001375 putative CoA binding site [chemical binding]; other site 247156001376 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 247156001377 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156001378 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156001379 active site 247156001380 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156001381 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 247156001382 FAD binding site [chemical binding]; other site 247156001383 substrate binding site [chemical binding]; other site 247156001384 catalytic base [active] 247156001385 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 247156001386 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 247156001387 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 247156001388 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156001389 NAD(P) binding site [chemical binding]; other site 247156001390 active site 247156001391 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 247156001392 Permease; Region: Permease; pfam02405 247156001393 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 247156001394 Permease; Region: Permease; pfam02405 247156001395 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 247156001396 mce related protein; Region: MCE; pfam02470 247156001397 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 247156001398 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 247156001399 mce related protein; Region: MCE; pfam02470 247156001400 mce related protein; Region: MCE; pfam02470 247156001401 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 247156001402 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 247156001403 mce related protein; Region: MCE; pfam02470 247156001404 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 247156001405 mce related protein; Region: MCE; pfam02470 247156001406 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 247156001407 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 247156001408 mce related protein; Region: MCE; pfam02470 247156001409 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 247156001410 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 247156001411 dimerization interface [polypeptide binding]; other site 247156001412 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 247156001413 dimer interface [polypeptide binding]; other site 247156001414 phosphorylation site [posttranslational modification] 247156001415 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 247156001416 ATP binding site [chemical binding]; other site 247156001417 Mg2+ binding site [ion binding]; other site 247156001418 G-X-G motif; other site 247156001419 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 247156001420 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 247156001421 active site 247156001422 phosphorylation site [posttranslational modification] 247156001423 intermolecular recognition site; other site 247156001424 dimerization interface [polypeptide binding]; other site 247156001425 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 247156001426 DNA binding site [nucleotide binding] 247156001427 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 247156001428 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 247156001429 active site 247156001430 homotetramer interface [polypeptide binding]; other site 247156001431 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 247156001432 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 247156001433 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 247156001434 MbtH-like protein; Region: MbtH; pfam03621 247156001435 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 247156001436 nucleotide binding site/active site [active] 247156001437 HIT family signature motif; other site 247156001438 catalytic residue [active] 247156001439 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 247156001440 pentamer interface [polypeptide binding]; other site 247156001441 dodecaamer interface [polypeptide binding]; other site 247156001442 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 247156001443 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 247156001444 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 247156001445 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 247156001446 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 247156001447 Peptidase family M23; Region: Peptidase_M23; pfam01551 247156001448 aspartate aminotransferase; Provisional; Region: PRK05764 247156001449 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 247156001450 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156001451 homodimer interface [polypeptide binding]; other site 247156001452 catalytic residue [active] 247156001453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 247156001454 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 247156001455 tetramer interface [polypeptide binding]; other site 247156001456 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 247156001457 HIT family signature motif; other site 247156001458 catalytic residue [active] 247156001459 Putative esterase; Region: Esterase; pfam00756 247156001460 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; pfam10092 247156001461 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 247156001462 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 247156001463 Predicted deacetylase [General function prediction only]; Region: COG3233 247156001464 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 247156001465 putative active site [active] 247156001466 putative Zn binding site [ion binding]; other site 247156001467 hypothetical protein; Provisional; Region: PRK07907 247156001468 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 247156001469 active site 247156001470 metal binding site [ion binding]; metal-binding site 247156001471 dimer interface [polypeptide binding]; other site 247156001472 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 247156001473 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 247156001474 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 247156001475 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 247156001476 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 247156001477 putative active site [active] 247156001478 catalytic triad [active] 247156001479 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 247156001480 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 247156001481 putative ligand binding site [chemical binding]; other site 247156001482 Transcriptional regulators [Transcription]; Region: MarR; COG1846 247156001483 MarR family; Region: MarR; pfam01047 247156001484 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 247156001485 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 247156001486 active site 247156001487 metal binding site [ion binding]; metal-binding site 247156001488 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 247156001489 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 247156001490 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 247156001491 dimerization interface [polypeptide binding]; other site 247156001492 ATP binding site [chemical binding]; other site 247156001493 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 247156001494 dimerization interface [polypeptide binding]; other site 247156001495 ATP binding site [chemical binding]; other site 247156001496 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 247156001497 Predicted membrane protein [Function unknown]; Region: COG4425 247156001498 CAAX protease self-immunity; Region: Abi; pfam02517 247156001499 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 247156001500 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 247156001501 amidophosphoribosyltransferase; Provisional; Region: PRK07847 247156001502 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 247156001503 tetramer interface [polypeptide binding]; other site 247156001504 active site 247156001505 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 247156001506 active site 247156001507 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 247156001508 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 247156001509 dimerization interface [polypeptide binding]; other site 247156001510 putative ATP binding site [chemical binding]; other site 247156001511 L-asparaginase II; Region: Asparaginase_II; pfam06089 247156001512 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 247156001513 MOSC domain; Region: MOSC; pfam03473 247156001514 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 247156001515 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 247156001516 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 247156001517 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 247156001518 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 247156001519 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156001520 catalytic residue [active] 247156001521 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 247156001522 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 247156001523 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 247156001524 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 247156001525 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 247156001526 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 247156001527 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 247156001528 Walker A/P-loop; other site 247156001529 ATP binding site [chemical binding]; other site 247156001530 Q-loop/lid; other site 247156001531 ABC transporter signature motif; other site 247156001532 Walker B; other site 247156001533 D-loop; other site 247156001534 H-loop/switch region; other site 247156001535 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 247156001536 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156001537 Walker A/P-loop; other site 247156001538 ATP binding site [chemical binding]; other site 247156001539 Q-loop/lid; other site 247156001540 ABC transporter signature motif; other site 247156001541 Walker B; other site 247156001542 D-loop; other site 247156001543 H-loop/switch region; other site 247156001544 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 247156001545 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 247156001546 heme-binding site [chemical binding]; other site 247156001547 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 247156001548 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 247156001549 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 247156001550 active site residue [active] 247156001551 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 247156001552 active site residue [active] 247156001553 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 247156001554 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 247156001555 catalytic residues [active] 247156001556 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 247156001557 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 247156001558 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 247156001559 DNA binding site [nucleotide binding] 247156001560 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 247156001561 PBP superfamily domain; Region: PBP_like_2; cl17296 247156001562 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 247156001563 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 247156001564 dimer interface [polypeptide binding]; other site 247156001565 conserved gate region; other site 247156001566 putative PBP binding loops; other site 247156001567 ABC-ATPase subunit interface; other site 247156001568 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 247156001569 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 247156001570 dimer interface [polypeptide binding]; other site 247156001571 conserved gate region; other site 247156001572 putative PBP binding loops; other site 247156001573 ABC-ATPase subunit interface; other site 247156001574 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 247156001575 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 247156001576 Walker A/P-loop; other site 247156001577 ATP binding site [chemical binding]; other site 247156001578 Q-loop/lid; other site 247156001579 ABC transporter signature motif; other site 247156001580 Walker B; other site 247156001581 D-loop; other site 247156001582 H-loop/switch region; other site 247156001583 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 247156001584 PhoU domain; Region: PhoU; pfam01895 247156001585 PhoU domain; Region: PhoU; pfam01895 247156001586 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 247156001587 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 247156001588 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 247156001589 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 247156001590 FMN binding site [chemical binding]; other site 247156001591 active site 247156001592 catalytic residues [active] 247156001593 substrate binding site [chemical binding]; other site 247156001594 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 247156001595 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 247156001596 homodimer interface [polypeptide binding]; other site 247156001597 putative substrate binding pocket [chemical binding]; other site 247156001598 diiron center [ion binding]; other site 247156001599 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 247156001600 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156001601 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156001602 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 247156001603 active site 247156001604 NTP binding site [chemical binding]; other site 247156001605 metal binding triad [ion binding]; metal-binding site 247156001606 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 247156001607 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 247156001608 Ligand binding site; other site 247156001609 Putative Catalytic site; other site 247156001610 DXD motif; other site 247156001611 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 247156001612 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 247156001613 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 247156001614 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 247156001615 putative acyl-acceptor binding pocket; other site 247156001616 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 247156001617 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 247156001618 putative acyl-acceptor binding pocket; other site 247156001619 salicylate synthase MbtI; Reviewed; Region: PRK07912 247156001620 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 247156001621 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 247156001622 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 247156001623 acyl-activating enzyme (AAE) consensus motif; other site 247156001624 active site 247156001625 AMP binding site [chemical binding]; other site 247156001626 substrate binding site [chemical binding]; other site 247156001627 short chain dehydrogenase; Provisional; Region: PRK06197 247156001628 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 247156001629 putative NAD(P) binding site [chemical binding]; other site 247156001630 active site 247156001631 Uncharacterized conserved protein [Function unknown]; Region: COG2128 247156001632 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 247156001633 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 247156001634 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 247156001635 protein-L-isoaspartate O-methyltransferase; Provisional; Region: PRK13942 247156001636 aminotransferase; Validated; Region: PRK07777 247156001637 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 247156001638 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156001639 homodimer interface [polypeptide binding]; other site 247156001640 catalytic residue [active] 247156001641 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 247156001642 RibD C-terminal domain; Region: RibD_C; cl17279 247156001643 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 247156001644 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 247156001645 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 247156001646 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 247156001647 putative Mg++ binding site [ion binding]; other site 247156001648 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 247156001649 nucleotide binding region [chemical binding]; other site 247156001650 ATP-binding site [chemical binding]; other site 247156001651 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 247156001652 LysE type translocator; Region: LysE; cl00565 247156001653 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 247156001654 Zn binding site [ion binding]; other site 247156001655 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 247156001656 WYL domain; Region: WYL; cl14852 247156001657 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 247156001658 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 247156001659 DNA-binding site [nucleotide binding]; DNA binding site 247156001660 RNA-binding motif; other site 247156001661 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 247156001662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156001663 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 247156001664 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 247156001665 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 247156001666 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 247156001667 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 247156001668 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156001669 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156001670 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 247156001671 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 247156001672 MarR family; Region: MarR_2; cl17246 247156001673 hypothetical protein; Provisional; Region: PRK11770 247156001674 Domain of unknown function (DUF307); Region: DUF307; pfam03733 247156001675 Domain of unknown function (DUF307); Region: DUF307; pfam03733 247156001676 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 247156001677 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 247156001678 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 247156001679 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 247156001680 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 247156001681 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 247156001682 catalytic residue [active] 247156001683 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 247156001684 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 247156001685 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 247156001686 dimer interface [polypeptide binding]; other site 247156001687 active site 247156001688 citrylCoA binding site [chemical binding]; other site 247156001689 NADH binding [chemical binding]; other site 247156001690 cationic pore residues; other site 247156001691 oxalacetate/citrate binding site [chemical binding]; other site 247156001692 coenzyme A binding site [chemical binding]; other site 247156001693 catalytic triad [active] 247156001694 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 247156001695 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 247156001696 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 247156001697 citrate synthase 2; Provisional; Region: PRK12350 247156001698 Citrate synthase; Region: Citrate_synt; pfam00285 247156001699 oxalacetate binding site [chemical binding]; other site 247156001700 citrylCoA binding site [chemical binding]; other site 247156001701 coenzyme A binding site [chemical binding]; other site 247156001702 catalytic triad [active] 247156001703 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 247156001704 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 247156001705 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 247156001706 phosphorylation site [posttranslational modification] 247156001707 dimer interface [polypeptide binding]; other site 247156001708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 247156001709 Mg2+ binding site [ion binding]; other site 247156001710 G-X-G motif; other site 247156001711 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 247156001712 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 247156001713 active site 247156001714 phosphorylation site [posttranslational modification] 247156001715 intermolecular recognition site; other site 247156001716 dimerization interface [polypeptide binding]; other site 247156001717 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 247156001718 DNA binding site [nucleotide binding] 247156001719 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 247156001720 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 247156001721 acyl-activating enzyme (AAE) consensus motif; other site 247156001722 AMP binding site [chemical binding]; other site 247156001723 active site 247156001724 CoA binding site [chemical binding]; other site 247156001725 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 247156001726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 247156001727 ATP binding site [chemical binding]; other site 247156001728 Mg2+ binding site [ion binding]; other site 247156001729 G-X-G motif; other site 247156001730 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 247156001731 Protein of unknown function (DUF742); Region: DUF742; pfam05331 247156001732 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 247156001733 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 247156001734 G1 box; other site 247156001735 GTP/Mg2+ binding site [chemical binding]; other site 247156001736 G2 box; other site 247156001737 Switch I region; other site 247156001738 G3 box; other site 247156001739 Switch II region; other site 247156001740 G4 box; other site 247156001741 G5 box; other site 247156001742 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 247156001743 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 247156001744 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 247156001745 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 247156001746 active site 247156001747 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 247156001748 catalytic tetrad [active] 247156001749 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 247156001750 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 247156001751 enoyl-CoA hydratase; Provisional; Region: PRK05995 247156001752 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 247156001753 substrate binding site [chemical binding]; other site 247156001754 oxyanion hole (OAH) forming residues; other site 247156001755 trimer interface [polypeptide binding]; other site 247156001756 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 247156001757 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 247156001758 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 247156001759 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 247156001760 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 247156001761 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 247156001762 nucleotide binding site [chemical binding]; other site 247156001763 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 247156001764 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 247156001765 active site 247156001766 DNA binding site [nucleotide binding] 247156001767 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 247156001768 DNA binding site [nucleotide binding] 247156001769 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 247156001770 UGMP family protein; Provisional; Region: PRK14878 247156001771 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 247156001772 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 247156001773 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 247156001774 Walker A/P-loop; other site 247156001775 ATP binding site [chemical binding]; other site 247156001776 Q-loop/lid; other site 247156001777 ABC transporter signature motif; other site 247156001778 Walker B; other site 247156001779 D-loop; other site 247156001780 H-loop/switch region; other site 247156001781 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 247156001782 Walker A/P-loop; other site 247156001783 ATP binding site [chemical binding]; other site 247156001784 Q-loop/lid; other site 247156001785 ABC transporter signature motif; other site 247156001786 Walker B; other site 247156001787 D-loop; other site 247156001788 H-loop/switch region; other site 247156001789 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 247156001790 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 247156001791 active site 247156001792 metal binding site [ion binding]; metal-binding site 247156001793 hexamer interface [polypeptide binding]; other site 247156001794 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 247156001795 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 247156001796 active site 247156001797 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 247156001798 cyclase homology domain; Region: CHD; cd07302 247156001799 nucleotidyl binding site; other site 247156001800 metal binding site [ion binding]; metal-binding site 247156001801 dimer interface [polypeptide binding]; other site 247156001802 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 247156001803 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 247156001804 homodimer interface [polypeptide binding]; other site 247156001805 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156001806 catalytic residue [active] 247156001807 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 247156001808 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 247156001809 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 247156001810 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 247156001811 putative DNA binding site [nucleotide binding]; other site 247156001812 putative Zn2+ binding site [ion binding]; other site 247156001813 Divergent AAA domain; Region: AAA_4; pfam04326 247156001814 Hemerythrin-like domain; Region: Hr-like; cd12108 247156001815 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 247156001816 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 247156001817 putative active site [active] 247156001818 putative metal binding site [ion binding]; other site 247156001819 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 247156001820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 247156001821 active site 247156001822 phosphorylation site [posttranslational modification] 247156001823 intermolecular recognition site; other site 247156001824 dimerization interface [polypeptide binding]; other site 247156001825 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 247156001826 DNA binding site [nucleotide binding] 247156001827 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 247156001828 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 247156001829 dimerization interface [polypeptide binding]; other site 247156001830 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 247156001831 dimer interface [polypeptide binding]; other site 247156001832 phosphorylation site [posttranslational modification] 247156001833 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 247156001834 ATP binding site [chemical binding]; other site 247156001835 Mg2+ binding site [ion binding]; other site 247156001836 G-X-G motif; other site 247156001837 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 247156001838 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 247156001839 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156001840 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156001841 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 247156001842 DNA-binding site [nucleotide binding]; DNA binding site 247156001843 AAA domain; Region: AAA_33; pfam13671 247156001844 AAA domain; Region: AAA_17; pfam13207 247156001845 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 247156001846 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 247156001847 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 247156001848 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 247156001849 active site 247156001850 Int/Topo IB signature motif; other site 247156001851 DNA binding site [nucleotide binding] 247156001852 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 247156001853 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 247156001854 dimer interface [polypeptide binding]; other site 247156001855 acyl-activating enzyme (AAE) consensus motif; other site 247156001856 putative active site [active] 247156001857 AMP binding site [chemical binding]; other site 247156001858 putative CoA binding site [chemical binding]; other site 247156001859 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 247156001860 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 247156001861 Nitronate monooxygenase; Region: NMO; pfam03060 247156001862 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 247156001863 FMN binding site [chemical binding]; other site 247156001864 substrate binding site [chemical binding]; other site 247156001865 putative catalytic residue [active] 247156001866 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 247156001867 Peptidase family M23; Region: Peptidase_M23; pfam01551 247156001868 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156001869 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 247156001870 acyl-activating enzyme (AAE) consensus motif; other site 247156001871 AMP binding site [chemical binding]; other site 247156001872 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156001873 Condensation domain; Region: Condensation; pfam00668 247156001874 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 247156001875 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 247156001876 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156001877 acyl-activating enzyme (AAE) consensus motif; other site 247156001878 AMP binding site [chemical binding]; other site 247156001879 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156001880 Condensation domain; Region: Condensation; pfam00668 247156001881 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 247156001882 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 247156001883 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 247156001884 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156001885 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 247156001886 acyl-activating enzyme (AAE) consensus motif; other site 247156001887 AMP binding site [chemical binding]; other site 247156001888 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156001889 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 247156001890 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 247156001891 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156001892 acyl-activating enzyme (AAE) consensus motif; other site 247156001893 AMP binding site [chemical binding]; other site 247156001894 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156001895 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156001896 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 247156001897 acyl-activating enzyme (AAE) consensus motif; other site 247156001898 AMP binding site [chemical binding]; other site 247156001899 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156001900 Condensation domain; Region: Condensation; pfam00668 247156001901 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 247156001902 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 247156001903 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156001904 acyl-activating enzyme (AAE) consensus motif; other site 247156001905 AMP binding site [chemical binding]; other site 247156001906 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156001907 Condensation domain; Region: Condensation; pfam00668 247156001908 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 247156001909 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 247156001910 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156001911 acyl-activating enzyme (AAE) consensus motif; other site 247156001912 AMP binding site [chemical binding]; other site 247156001913 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156001914 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 247156001915 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156001916 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 247156001917 acyl-activating enzyme (AAE) consensus motif; other site 247156001918 AMP binding site [chemical binding]; other site 247156001919 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156001920 Condensation domain; Region: Condensation; pfam00668 247156001921 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 247156001922 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 247156001923 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156001924 acyl-activating enzyme (AAE) consensus motif; other site 247156001925 AMP binding site [chemical binding]; other site 247156001926 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156001927 Condensation domain; Region: Condensation; pfam00668 247156001928 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 247156001929 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156001930 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 247156001931 acyl-activating enzyme (AAE) consensus motif; other site 247156001932 AMP binding site [chemical binding]; other site 247156001933 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156001934 Condensation domain; Region: Condensation; pfam00668 247156001935 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 247156001936 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 247156001937 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156001938 acyl-activating enzyme (AAE) consensus motif; other site 247156001939 AMP binding site [chemical binding]; other site 247156001940 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 247156001941 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 247156001942 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156001943 acyl-activating enzyme (AAE) consensus motif; other site 247156001944 AMP binding site [chemical binding]; other site 247156001945 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156001946 Putative esterase; Region: Esterase; pfam00756 247156001947 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 247156001948 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156001949 NAD(P) binding site [chemical binding]; other site 247156001950 active site 247156001951 enoyl-CoA hydratase; Provisional; Region: PRK06688 247156001952 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 247156001953 substrate binding site [chemical binding]; other site 247156001954 oxyanion hole (OAH) forming residues; other site 247156001955 trimer interface [polypeptide binding]; other site 247156001956 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156001957 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156001958 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156001959 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156001960 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 247156001961 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 247156001962 NAD(P) binding site [chemical binding]; other site 247156001963 catalytic residues [active] 247156001964 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156001965 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 247156001966 Walker A/P-loop; other site 247156001967 ATP binding site [chemical binding]; other site 247156001968 Q-loop/lid; other site 247156001969 ABC transporter signature motif; other site 247156001970 Walker B; other site 247156001971 D-loop; other site 247156001972 H-loop/switch region; other site 247156001973 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 247156001974 ABC-2 type transporter; Region: ABC2_membrane; cl17235 247156001975 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 247156001976 ABC-2 type transporter; Region: ABC2_membrane; cl17235 247156001977 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 247156001978 TrkA-N domain; Region: TrkA_N; pfam02254 247156001979 lycopene cyclase; Region: lycopene_cycl; TIGR01789 247156001980 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 247156001981 CoenzymeA binding site [chemical binding]; other site 247156001982 subunit interaction site [polypeptide binding]; other site 247156001983 PHB binding site; other site 247156001984 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 247156001985 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 247156001986 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 247156001987 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 247156001988 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 247156001989 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 247156001990 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 247156001991 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 247156001992 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 247156001993 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 247156001994 putative translocon binding site; other site 247156001995 protein-rRNA interface [nucleotide binding]; other site 247156001996 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 247156001997 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 247156001998 G-X-X-G motif; other site 247156001999 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 247156002000 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 247156002001 23S rRNA interface [nucleotide binding]; other site 247156002002 5S rRNA interface [nucleotide binding]; other site 247156002003 putative antibiotic binding site [chemical binding]; other site 247156002004 L25 interface [polypeptide binding]; other site 247156002005 L27 interface [polypeptide binding]; other site 247156002006 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 247156002007 L23 interface [polypeptide binding]; other site 247156002008 signal recognition particle (SRP54) interaction site; other site 247156002009 trigger factor interaction site; other site 247156002010 23S rRNA interface [nucleotide binding]; other site 247156002011 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 247156002012 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 247156002013 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 247156002014 nudix motif; other site 247156002015 CAAX protease self-immunity; Region: Abi; pfam02517 247156002016 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 247156002017 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 247156002018 probable active site [active] 247156002019 PPOX class probable F420-dependent enzyme, Rv3369 family; Region: Rv3369; TIGR03667 247156002020 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 247156002021 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 247156002022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156002023 Walker A/P-loop; other site 247156002024 ATP binding site [chemical binding]; other site 247156002025 Q-loop/lid; other site 247156002026 ABC transporter signature motif; other site 247156002027 Walker B; other site 247156002028 D-loop; other site 247156002029 H-loop/switch region; other site 247156002030 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 247156002031 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156002032 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 247156002033 Walker A/P-loop; other site 247156002034 ATP binding site [chemical binding]; other site 247156002035 Q-loop/lid; other site 247156002036 ABC transporter signature motif; other site 247156002037 Walker B; other site 247156002038 D-loop; other site 247156002039 H-loop/switch region; other site 247156002040 MarR family; Region: MarR_2; cl17246 247156002041 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 247156002042 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 247156002043 putative ligand binding site [chemical binding]; other site 247156002044 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 247156002045 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 247156002046 Walker A motif; other site 247156002047 ATP binding site [chemical binding]; other site 247156002048 Walker B motif; other site 247156002049 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 247156002050 acylamide amidohydrolase; Provisional; Region: amiE; PRK13286 247156002051 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 247156002052 multimer interface [polypeptide binding]; other site 247156002053 active site 247156002054 catalytic triad [active] 247156002055 dimer interface [polypeptide binding]; other site 247156002056 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 247156002057 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 247156002058 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 247156002059 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 247156002060 FAD binding pocket [chemical binding]; other site 247156002061 FAD binding motif [chemical binding]; other site 247156002062 phosphate binding motif [ion binding]; other site 247156002063 NAD binding pocket [chemical binding]; other site 247156002064 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 247156002065 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 247156002066 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 247156002067 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 247156002068 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 247156002069 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 247156002070 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 247156002071 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 247156002072 active site 247156002073 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 247156002074 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 247156002075 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 247156002076 NADP binding site [chemical binding]; other site 247156002077 active site 247156002078 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 247156002079 Condensation domain; Region: Condensation; pfam00668 247156002080 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 247156002081 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 247156002082 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156002083 acyl-activating enzyme (AAE) consensus motif; other site 247156002084 AMP binding site [chemical binding]; other site 247156002085 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156002086 Condensation domain; Region: Condensation; pfam00668 247156002087 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 247156002088 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 247156002089 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156002090 Condensation domain; Region: Condensation; pfam00668 247156002091 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 247156002092 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156002093 acyl-activating enzyme (AAE) consensus motif; other site 247156002094 AMP binding site [chemical binding]; other site 247156002095 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156002096 Condensation domain; Region: Condensation; pfam00668 247156002097 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 247156002098 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 247156002099 Condensation domain; Region: Condensation; pfam00668 247156002100 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 247156002101 Nonribosomal peptide synthase; Region: NRPS; pfam08415 247156002102 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 247156002103 acyl-activating enzyme (AAE) consensus motif; other site 247156002104 AMP binding site [chemical binding]; other site 247156002105 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156002106 PemK-like protein; Region: PemK; pfam02452 247156002107 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 247156002108 putative FMN binding site [chemical binding]; other site 247156002109 NADPH bind site [chemical binding]; other site 247156002110 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 247156002111 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 247156002112 intersubunit interface [polypeptide binding]; other site 247156002113 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 247156002114 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 247156002115 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 247156002116 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 247156002117 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 247156002118 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 247156002119 RNA binding site [nucleotide binding]; other site 247156002120 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 247156002121 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 247156002122 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 247156002123 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 247156002124 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 247156002125 putative active site [active] 247156002126 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 247156002127 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 247156002128 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 247156002129 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 247156002130 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 247156002131 active site 247156002132 phosphorylation site [posttranslational modification] 247156002133 intermolecular recognition site; other site 247156002134 dimerization interface [polypeptide binding]; other site 247156002135 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 247156002136 DNA binding residues [nucleotide binding] 247156002137 dimerization interface [polypeptide binding]; other site 247156002138 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 247156002139 dimerization interface [polypeptide binding]; other site 247156002140 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 247156002141 Histidine kinase; Region: HisKA_3; pfam07730 247156002142 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 247156002143 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 247156002144 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 247156002145 transmembrane helices; other site 247156002146 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 247156002147 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 247156002148 DNA binding residues [nucleotide binding] 247156002149 dimer interface [polypeptide binding]; other site 247156002150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156002151 S-adenosylmethionine binding site [chemical binding]; other site 247156002152 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156002153 S-adenosylmethionine binding site [chemical binding]; other site 247156002154 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 247156002155 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 247156002156 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 247156002157 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 247156002158 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 247156002159 5S rRNA interface [nucleotide binding]; other site 247156002160 L27 interface [polypeptide binding]; other site 247156002161 23S rRNA interface [nucleotide binding]; other site 247156002162 L5 interface [polypeptide binding]; other site 247156002163 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 247156002164 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 247156002165 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 247156002166 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 247156002167 23S rRNA binding site [nucleotide binding]; other site 247156002168 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 247156002169 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 247156002170 SecY translocase; Region: SecY; pfam00344 247156002171 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 247156002172 Adenylate kinase; Region: ADK; pfam00406 247156002173 AMP-binding site [chemical binding]; other site 247156002174 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 247156002175 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 247156002176 active site 247156002177 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 247156002178 YwqJ-like deaminase; Region: YwqJ-deaminase; pfam14431 247156002179 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 247156002180 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 247156002181 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 247156002182 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 247156002183 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156002184 NAD(P) binding site [chemical binding]; other site 247156002185 active site 247156002186 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 247156002187 putative active site [active] 247156002188 dimerization interface [polypeptide binding]; other site 247156002189 putative tRNAtyr binding site [nucleotide binding]; other site 247156002190 EspG family; Region: ESX-1_EspG; pfam14011 247156002191 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 247156002192 EspG family; Region: ESX-1_EspG; pfam14011 247156002193 PPE family; Region: PPE; pfam00823 247156002194 EspG family; Region: ESX-1_EspG; pfam14011 247156002195 Proteins of 100 residues with WXG; Region: WXG100; cl02005 247156002196 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 247156002197 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 247156002198 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 247156002199 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 247156002200 TPR motif; other site 247156002201 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 247156002202 Walker A motif; other site 247156002203 ATP binding site [chemical binding]; other site 247156002204 Walker B motif; other site 247156002205 arginine finger; other site 247156002206 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 247156002207 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 247156002208 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 247156002209 active site 247156002210 catalytic residues [active] 247156002211 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 247156002212 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 247156002213 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 247156002214 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 247156002215 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 247156002216 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 247156002217 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 247156002218 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 247156002219 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 247156002220 rRNA binding site [nucleotide binding]; other site 247156002221 predicted 30S ribosome binding site; other site 247156002222 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 247156002223 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 247156002224 30S ribosomal protein S13; Region: bact_S13; TIGR03631 247156002225 30S ribosomal protein S11; Validated; Region: PRK05309 247156002226 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 247156002227 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 247156002228 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 247156002229 RNA binding surface [nucleotide binding]; other site 247156002230 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 247156002231 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 247156002232 alphaNTD - beta interaction site [polypeptide binding]; other site 247156002233 alphaNTD homodimer interface [polypeptide binding]; other site 247156002234 alphaNTD - beta' interaction site [polypeptide binding]; other site 247156002235 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 247156002236 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 247156002237 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 247156002238 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 247156002239 active site 247156002240 dimerization interface 3.5A [polypeptide binding]; other site 247156002241 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 247156002242 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 247156002243 putative dimer interface [polypeptide binding]; other site 247156002244 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 247156002245 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 247156002246 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 247156002247 putative homodimer interface [polypeptide binding]; other site 247156002248 putative homotetramer interface [polypeptide binding]; other site 247156002249 putative allosteric switch controlling residues; other site 247156002250 putative metal binding site [ion binding]; other site 247156002251 putative homodimer-homodimer interface [polypeptide binding]; other site 247156002252 EamA-like transporter family; Region: EamA; pfam00892 247156002253 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 247156002254 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 247156002255 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 247156002256 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 247156002257 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 247156002258 Ion transport protein; Region: Ion_trans; pfam00520 247156002259 Ion channel; Region: Ion_trans_2; pfam07885 247156002260 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 247156002261 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 247156002262 active site 247156002263 catalytic residues [active] 247156002264 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 247156002265 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 247156002266 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 247156002267 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 247156002268 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 247156002269 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 247156002270 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 247156002271 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 247156002272 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 247156002273 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 247156002274 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 247156002275 Catalytic domain of Protein Kinases; Region: PKc; cd00180 247156002276 active site 247156002277 ATP binding site [chemical binding]; other site 247156002278 substrate binding site [chemical binding]; other site 247156002279 activation loop (A-loop); other site 247156002280 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 247156002281 phosphopeptide binding site; other site 247156002282 Predicted metalloprotease [General function prediction only]; Region: COG2321 247156002283 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 247156002284 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 247156002285 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 247156002286 phosphopeptide binding site; other site 247156002287 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 247156002288 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 247156002289 phosphopeptide binding site; other site 247156002290 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 247156002291 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 247156002292 Walker A/P-loop; other site 247156002293 ATP binding site [chemical binding]; other site 247156002294 Q-loop/lid; other site 247156002295 ABC transporter signature motif; other site 247156002296 Walker B; other site 247156002297 D-loop; other site 247156002298 H-loop/switch region; other site 247156002299 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 247156002300 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 247156002301 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 247156002302 23S rRNA interface [nucleotide binding]; other site 247156002303 L3 interface [polypeptide binding]; other site 247156002304 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 247156002305 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 247156002306 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 247156002307 active site 247156002308 substrate binding site [chemical binding]; other site 247156002309 metal binding site [ion binding]; metal-binding site 247156002310 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 247156002311 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 247156002312 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156002313 Walker A/P-loop; other site 247156002314 ATP binding site [chemical binding]; other site 247156002315 Q-loop/lid; other site 247156002316 ABC transporter signature motif; other site 247156002317 Walker B; other site 247156002318 D-loop; other site 247156002319 H-loop/switch region; other site 247156002320 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 247156002321 PspC domain; Region: PspC; pfam04024 247156002322 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 247156002323 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 247156002324 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 247156002325 glutaminase active site [active] 247156002326 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 247156002327 dimer interface [polypeptide binding]; other site 247156002328 active site 247156002329 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 247156002330 dimer interface [polypeptide binding]; other site 247156002331 active site 247156002332 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 247156002333 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 247156002334 Uncharacterized conserved protein [Function unknown]; Region: COG0062 247156002335 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 247156002336 putative substrate binding site [chemical binding]; other site 247156002337 putative ATP binding site [chemical binding]; other site 247156002338 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 247156002339 alanine racemase; Reviewed; Region: alr; PRK00053 247156002340 active site 247156002341 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 247156002342 dimer interface [polypeptide binding]; other site 247156002343 substrate binding site [chemical binding]; other site 247156002344 catalytic residues [active] 247156002345 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 247156002346 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 247156002347 TAP-like protein; Region: Abhydrolase_4; pfam08386 247156002348 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 247156002349 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 247156002350 Glycoprotease family; Region: Peptidase_M22; pfam00814 247156002351 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 247156002352 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 247156002353 Coenzyme A binding pocket [chemical binding]; other site 247156002354 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 247156002355 UGMP family protein; Validated; Region: PRK09604 247156002356 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 247156002357 nucleotide binding site [chemical binding]; other site 247156002358 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 247156002359 oligomerisation interface [polypeptide binding]; other site 247156002360 mobile loop; other site 247156002361 roof hairpin; other site 247156002362 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 247156002363 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 247156002364 ring oligomerisation interface [polypeptide binding]; other site 247156002365 ATP/Mg binding site [chemical binding]; other site 247156002366 stacking interactions; other site 247156002367 hinge regions; other site 247156002368 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 247156002369 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 247156002370 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 247156002371 DNA binding residues [nucleotide binding] 247156002372 Transcription factor WhiB; Region: Whib; pfam02467 247156002373 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 247156002374 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 247156002375 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 247156002376 DNA binding residues [nucleotide binding] 247156002377 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 247156002378 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 247156002379 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 247156002380 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 247156002381 active site 247156002382 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 247156002383 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 247156002384 active site 247156002385 GMP synthase; Reviewed; Region: guaA; PRK00074 247156002386 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 247156002387 AMP/PPi binding site [chemical binding]; other site 247156002388 candidate oxyanion hole; other site 247156002389 catalytic triad [active] 247156002390 potential glutamine specificity residues [chemical binding]; other site 247156002391 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 247156002392 ATP Binding subdomain [chemical binding]; other site 247156002393 Ligand Binding sites [chemical binding]; other site 247156002394 Dimerization subdomain; other site 247156002395 PspC domain; Region: PspC; pfam04024 247156002396 MspA; Region: MspA; pfam09203 247156002397 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 247156002398 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 247156002399 ATP binding site [chemical binding]; other site 247156002400 Mg2+ binding site [ion binding]; other site 247156002401 G-X-G motif; other site 247156002402 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 247156002403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 247156002404 active site 247156002405 phosphorylation site [posttranslational modification] 247156002406 intermolecular recognition site; other site 247156002407 dimerization interface [polypeptide binding]; other site 247156002408 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 247156002409 DNA binding residues [nucleotide binding] 247156002410 dimerization interface [polypeptide binding]; other site 247156002411 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 247156002412 Catalytic domain of Protein Kinases; Region: PKc; cd00180 247156002413 active site 247156002414 ATP binding site [chemical binding]; other site 247156002415 substrate binding site [chemical binding]; other site 247156002416 activation loop (A-loop); other site 247156002417 DNA Polymerase Y-family; Region: PolY_like; cd03468 247156002418 DNA binding site [nucleotide binding] 247156002419 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 247156002420 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 247156002421 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 247156002422 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 247156002423 putative dimer interface [polypeptide binding]; other site 247156002424 putative [2Fe-2S] cluster binding site [ion binding]; other site 247156002425 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156002426 Uncharacterized conserved protein [Function unknown]; Region: COG3268 247156002427 NAD(P) binding site [chemical binding]; other site 247156002428 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 247156002429 classical (c) SDRs; Region: SDR_c; cd05233 247156002430 NAD(P) binding site [chemical binding]; other site 247156002431 active site 247156002432 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 247156002433 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 247156002434 active site 247156002435 PHP Thumb interface [polypeptide binding]; other site 247156002436 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 247156002437 generic binding surface II; other site 247156002438 generic binding surface I; other site 247156002439 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 247156002440 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 247156002441 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 247156002442 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 247156002443 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 247156002444 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 247156002445 isocitrate dehydrogenase; Validated; Region: PRK08299 247156002446 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 247156002447 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 247156002448 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 247156002449 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 247156002450 conserved cys residue [active] 247156002451 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 247156002452 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 247156002453 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 247156002454 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156002455 putative substrate translocation pore; other site 247156002456 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156002457 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156002458 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156002459 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156002460 active site 247156002461 short chain dehydrogenase; Provisional; Region: PRK07825 247156002462 classical (c) SDRs; Region: SDR_c; cd05233 247156002463 NAD(P) binding site [chemical binding]; other site 247156002464 active site 247156002465 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 247156002466 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 247156002467 putative active site [active] 247156002468 putative catalytic site [active] 247156002469 putative DNA binding site [nucleotide binding]; other site 247156002470 putative phosphate binding site [ion binding]; other site 247156002471 metal binding site A [ion binding]; metal-binding site 247156002472 putative AP binding site [nucleotide binding]; other site 247156002473 putative metal binding site B [ion binding]; other site 247156002474 ribonuclease; Region: Ribonuclease; pfam00545 247156002475 active site 247156002476 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 247156002477 putative RNAase interaction site [polypeptide binding]; other site 247156002478 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156002479 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156002480 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 247156002481 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 247156002482 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 247156002483 active site 247156002484 HIGH motif; other site 247156002485 dimer interface [polypeptide binding]; other site 247156002486 KMSKS motif; other site 247156002487 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 247156002488 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 247156002489 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 247156002490 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 247156002491 Major Facilitator Superfamily; Region: MFS_1; pfam07690 247156002492 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156002493 putative substrate translocation pore; other site 247156002494 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 247156002495 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156002496 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 247156002497 cofactor binding site; other site 247156002498 metal binding site [ion binding]; metal-binding site 247156002499 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 247156002500 hypothetical protein; Reviewed; Region: PRK00024 247156002501 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 247156002502 MPN+ (JAMM) motif; other site 247156002503 Zinc-binding site [ion binding]; other site 247156002504 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 247156002505 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 247156002506 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156002507 non-specific DNA binding site [nucleotide binding]; other site 247156002508 salt bridge; other site 247156002509 sequence-specific DNA binding site [nucleotide binding]; other site 247156002510 Domain of unknown function (DUF955); Region: DUF955; pfam06114 247156002511 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 247156002512 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 247156002513 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 247156002514 L-aspartate oxidase; Provisional; Region: PRK06175 247156002515 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 247156002516 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 247156002517 putative Iron-sulfur protein interface [polypeptide binding]; other site 247156002518 putative proximal heme binding site [chemical binding]; other site 247156002519 putative SdhC-like subunit interface [polypeptide binding]; other site 247156002520 putative distal heme binding site [chemical binding]; other site 247156002521 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 247156002522 putative Iron-sulfur protein interface [polypeptide binding]; other site 247156002523 putative proximal heme binding site [chemical binding]; other site 247156002524 putative SdhD-like interface [polypeptide binding]; other site 247156002525 putative distal heme binding site [chemical binding]; other site 247156002526 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 247156002527 active site 247156002528 catalytic motif [active] 247156002529 Zn binding site [ion binding]; other site 247156002530 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 247156002531 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 247156002532 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 247156002533 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 247156002534 adenosine deaminase; Provisional; Region: PRK09358 247156002535 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 247156002536 active site 247156002537 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 247156002538 NlpC/P60 family; Region: NLPC_P60; pfam00877 247156002539 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 247156002540 active site 247156002541 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 247156002542 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 247156002543 active site 247156002544 substrate binding site [chemical binding]; other site 247156002545 metal binding site [ion binding]; metal-binding site 247156002546 purine nucleoside phosphorylase; Provisional; Region: PRK08202 247156002547 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 247156002548 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 247156002549 substrate binding site [chemical binding]; other site 247156002550 oxyanion hole (OAH) forming residues; other site 247156002551 trimer interface [polypeptide binding]; other site 247156002552 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 247156002553 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 247156002554 metal binding site [ion binding]; metal-binding site 247156002555 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 247156002556 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 247156002557 metal binding site [ion binding]; metal-binding site 247156002558 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 247156002559 putative active site pocket [active] 247156002560 dimerization interface [polypeptide binding]; other site 247156002561 putative catalytic residue [active] 247156002562 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 247156002563 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 247156002564 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 247156002565 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 247156002566 large tegument protein UL36; Provisional; Region: PHA03247 247156002567 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 247156002568 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 247156002569 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 247156002570 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156002571 homodimer interface [polypeptide binding]; other site 247156002572 catalytic residue [active] 247156002573 glycerol kinase; Provisional; Region: glpK; PRK00047 247156002574 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 247156002575 N- and C-terminal domain interface [polypeptide binding]; other site 247156002576 active site 247156002577 MgATP binding site [chemical binding]; other site 247156002578 catalytic site [active] 247156002579 metal binding site [ion binding]; metal-binding site 247156002580 putative homotetramer interface [polypeptide binding]; other site 247156002581 glycerol binding site [chemical binding]; other site 247156002582 homodimer interface [polypeptide binding]; other site 247156002583 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 247156002584 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156002585 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156002586 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 247156002587 catalytic core [active] 247156002588 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 247156002589 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 247156002590 ATP binding site [chemical binding]; other site 247156002591 putative Mg++ binding site [ion binding]; other site 247156002592 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 247156002593 nucleotide binding region [chemical binding]; other site 247156002594 ATP-binding site [chemical binding]; other site 247156002595 DEAD/H associated; Region: DEAD_assoc; pfam08494 247156002596 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 247156002597 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 247156002598 putative DNA binding site [nucleotide binding]; other site 247156002599 catalytic residue [active] 247156002600 putative H2TH interface [polypeptide binding]; other site 247156002601 putative catalytic residues [active] 247156002602 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 247156002603 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 247156002604 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 247156002605 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 247156002606 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 247156002607 Protein of unknown function (DUF742); Region: DUF742; pfam05331 247156002608 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 247156002609 Nitrate and nitrite sensing; Region: NIT; pfam08376 247156002610 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 247156002611 ATP binding site [chemical binding]; other site 247156002612 Mg2+ binding site [ion binding]; other site 247156002613 G-X-G motif; other site 247156002614 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 247156002615 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 247156002616 tetrameric interface [polypeptide binding]; other site 247156002617 NAD binding site [chemical binding]; other site 247156002618 catalytic residues [active] 247156002619 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 247156002620 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 247156002621 AsnC family; Region: AsnC_trans_reg; pfam01037 247156002622 L-lysine aminotransferase; Provisional; Region: PRK08297 247156002623 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 247156002624 inhibitor-cofactor binding pocket; inhibition site 247156002625 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156002626 catalytic residue [active] 247156002627 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 247156002628 Catalytic domain of Protein Kinases; Region: PKc; cd00180 247156002629 active site 247156002630 ATP binding site [chemical binding]; other site 247156002631 substrate binding site [chemical binding]; other site 247156002632 activation loop (A-loop); other site 247156002633 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 247156002634 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 247156002635 active site 247156002636 nucleophile elbow; other site 247156002637 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 247156002638 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 247156002639 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 247156002640 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 247156002641 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 247156002642 carboxyltransferase (CT) interaction site; other site 247156002643 biotinylation site [posttranslational modification]; other site 247156002644 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 247156002645 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 247156002646 active site residue [active] 247156002647 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 247156002648 active site residue [active] 247156002649 Predicted transcriptional regulator [Transcription]; Region: COG2345 247156002650 Helix-turn-helix domain; Region: HTH_20; pfam12840 247156002651 putative DNA binding site [nucleotide binding]; other site 247156002652 putative Zn2+ binding site [ion binding]; other site 247156002653 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 247156002654 active site 247156002655 dimer interface [polypeptide binding]; other site 247156002656 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 247156002657 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 247156002658 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 247156002659 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 247156002660 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 247156002661 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 247156002662 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 247156002663 Bacterial PH domain; Region: DUF304; pfam03703 247156002664 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 247156002665 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 247156002666 active site 247156002667 phosphorylation site [posttranslational modification] 247156002668 intermolecular recognition site; other site 247156002669 dimerization interface [polypeptide binding]; other site 247156002670 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 247156002671 DNA binding site [nucleotide binding] 247156002672 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 247156002673 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 247156002674 dimer interface [polypeptide binding]; other site 247156002675 phosphorylation site [posttranslational modification] 247156002676 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 247156002677 ATP binding site [chemical binding]; other site 247156002678 Mg2+ binding site [ion binding]; other site 247156002679 G-X-G motif; other site 247156002680 Predicted membrane protein [Function unknown]; Region: COG2246 247156002681 GtrA-like protein; Region: GtrA; pfam04138 247156002682 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 247156002683 ATP-grasp domain; Region: ATP-grasp; pfam02222 247156002684 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 247156002685 PIN domain; Region: PIN_3; pfam13470 247156002686 DNA binding domain, excisionase family; Region: excise; TIGR01764 247156002687 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156002688 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156002689 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 247156002690 FAD binding site [chemical binding]; other site 247156002691 homotetramer interface [polypeptide binding]; other site 247156002692 substrate binding pocket [chemical binding]; other site 247156002693 catalytic base [active] 247156002694 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 247156002695 Coenzyme A binding pocket [chemical binding]; other site 247156002696 FAD binding domain; Region: FAD_binding_4; pfam01565 247156002697 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 247156002698 GtrA-like protein; Region: GtrA; pfam04138 247156002699 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 247156002700 conserved cys residue [active] 247156002701 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 247156002702 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 247156002703 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 247156002704 HIT family signature motif; other site 247156002705 catalytic residue [active] 247156002706 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 247156002707 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 247156002708 ligand binding site [chemical binding]; other site 247156002709 homodimer interface [polypeptide binding]; other site 247156002710 NAD(P) binding site [chemical binding]; other site 247156002711 trimer interface B [polypeptide binding]; other site 247156002712 trimer interface A [polypeptide binding]; other site 247156002713 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 247156002714 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 247156002715 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 247156002716 hypothetical protein; Provisional; Region: PRK06771 247156002717 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 247156002718 active site 247156002719 classical (c) SDRs; Region: SDR_c; cd05233 247156002720 NAD(P) binding site [chemical binding]; other site 247156002721 active site 247156002722 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 247156002723 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 247156002724 AsnC family; Region: AsnC_trans_reg; pfam01037 247156002725 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 247156002726 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 247156002727 tetramer interface [polypeptide binding]; other site 247156002728 TPP-binding site [chemical binding]; other site 247156002729 heterodimer interface [polypeptide binding]; other site 247156002730 phosphorylation loop region [posttranslational modification] 247156002731 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 247156002732 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 247156002733 alpha subunit interface [polypeptide binding]; other site 247156002734 TPP binding site [chemical binding]; other site 247156002735 heterodimer interface [polypeptide binding]; other site 247156002736 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 247156002737 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 247156002738 E3 interaction surface; other site 247156002739 lipoyl attachment site [posttranslational modification]; other site 247156002740 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 247156002741 e3 binding domain; Region: E3_binding; pfam02817 247156002742 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 247156002743 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 247156002744 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 247156002745 active site residue [active] 247156002746 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 247156002747 active site residue [active] 247156002748 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 247156002749 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156002750 non-specific DNA binding site [nucleotide binding]; other site 247156002751 salt bridge; other site 247156002752 sequence-specific DNA binding site [nucleotide binding]; other site 247156002753 Methyltransferase domain; Region: Methyltransf_23; pfam13489 247156002754 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 247156002755 DNA-binding site [nucleotide binding]; DNA binding site 247156002756 UTRA domain; Region: UTRA; cl17743 247156002757 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 247156002758 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 247156002759 SNF2 Helicase protein; Region: DUF3670; pfam12419 247156002760 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 247156002761 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 247156002762 ATP binding site [chemical binding]; other site 247156002763 putative Mg++ binding site [ion binding]; other site 247156002764 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 247156002765 nucleotide binding region [chemical binding]; other site 247156002766 ATP-binding site [chemical binding]; other site 247156002767 Uncharacterized conserved protein [Function unknown]; Region: COG4279 247156002768 SWIM zinc finger; Region: SWIM; pfam04434 247156002769 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 247156002770 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 247156002771 intersubunit interface [polypeptide binding]; other site 247156002772 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 247156002773 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 247156002774 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 247156002775 Amidohydrolase; Region: Amidohydro_2; pfam04909 247156002776 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 247156002777 B12 binding site [chemical binding]; other site 247156002778 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 247156002779 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 247156002780 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 247156002781 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 247156002782 tetrameric interface [polypeptide binding]; other site 247156002783 NAD binding site [chemical binding]; other site 247156002784 catalytic residues [active] 247156002785 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156002786 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156002787 active site 247156002788 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 247156002789 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 247156002790 substrate binding site [chemical binding]; other site 247156002791 oxyanion hole (OAH) forming residues; other site 247156002792 trimer interface [polypeptide binding]; other site 247156002793 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 247156002794 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 247156002795 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 247156002796 enoyl-CoA hydratase; Provisional; Region: PRK05862 247156002797 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 247156002798 substrate binding site [chemical binding]; other site 247156002799 oxyanion hole (OAH) forming residues; other site 247156002800 trimer interface [polypeptide binding]; other site 247156002801 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 247156002802 Transcriptional regulators [Transcription]; Region: MarR; COG1846 247156002803 MarR family; Region: MarR; pfam01047 247156002804 Domain of unknown function (DUF305); Region: DUF305; pfam03713 247156002805 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 247156002806 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 247156002807 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 247156002808 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 247156002809 active site 247156002810 HIGH motif; other site 247156002811 KMSK motif region; other site 247156002812 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 247156002813 tRNA binding surface [nucleotide binding]; other site 247156002814 anticodon binding site; other site 247156002815 diaminopimelate decarboxylase; Region: lysA; TIGR01048 247156002816 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 247156002817 active site 247156002818 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 247156002819 substrate binding site [chemical binding]; other site 247156002820 catalytic residues [active] 247156002821 dimer interface [polypeptide binding]; other site 247156002822 homoserine dehydrogenase; Provisional; Region: PRK06349 247156002823 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 247156002824 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 247156002825 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 247156002826 threonine synthase; Reviewed; Region: PRK06721 247156002827 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 247156002828 homodimer interface [polypeptide binding]; other site 247156002829 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156002830 catalytic residue [active] 247156002831 homoserine kinase; Provisional; Region: PRK01212 247156002832 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 247156002833 transcription termination factor Rho; Provisional; Region: PRK12608 247156002834 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 247156002835 RNA binding site [nucleotide binding]; other site 247156002836 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 247156002837 multimer interface [polypeptide binding]; other site 247156002838 Walker A motif; other site 247156002839 ATP binding site [chemical binding]; other site 247156002840 Walker B motif; other site 247156002841 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 247156002842 peptide chain release factor 1; Validated; Region: prfA; PRK00591 247156002843 PCRF domain; Region: PCRF; pfam03462 247156002844 RF-1 domain; Region: RF-1; pfam00472 247156002845 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 247156002846 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156002847 S-adenosylmethionine binding site [chemical binding]; other site 247156002848 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 247156002849 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 247156002850 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 247156002851 Mg++ binding site [ion binding]; other site 247156002852 putative catalytic motif [active] 247156002853 substrate binding site [chemical binding]; other site 247156002854 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 247156002855 F0F1 ATP synthase subunit C; Validated; Region: PRK07874 247156002856 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 247156002857 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 247156002858 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 247156002859 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 247156002860 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 247156002861 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 247156002862 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 247156002863 beta subunit interaction interface [polypeptide binding]; other site 247156002864 Walker A motif; other site 247156002865 ATP binding site [chemical binding]; other site 247156002866 Walker B motif; other site 247156002867 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 247156002868 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 247156002869 core domain interface [polypeptide binding]; other site 247156002870 delta subunit interface [polypeptide binding]; other site 247156002871 epsilon subunit interface [polypeptide binding]; other site 247156002872 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 247156002873 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 247156002874 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 247156002875 alpha subunit interaction interface [polypeptide binding]; other site 247156002876 Walker A motif; other site 247156002877 ATP binding site [chemical binding]; other site 247156002878 Walker B motif; other site 247156002879 inhibitor binding site; inhibition site 247156002880 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 247156002881 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 247156002882 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 247156002883 gamma subunit interface [polypeptide binding]; other site 247156002884 epsilon subunit interface [polypeptide binding]; other site 247156002885 LBP interface [polypeptide binding]; other site 247156002886 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 247156002887 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 247156002888 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 247156002889 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 247156002890 hinge; other site 247156002891 active site 247156002892 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 247156002893 hypothetical protein; Provisional; Region: PRK03298 247156002894 major vault protein; Provisional; Region: PTZ00491 247156002895 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 247156002896 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 247156002897 dimer interface [polypeptide binding]; other site 247156002898 substrate binding site [chemical binding]; other site 247156002899 putative acyltransferase; Provisional; Region: PRK05790 247156002900 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 247156002901 dimer interface [polypeptide binding]; other site 247156002902 active site 247156002903 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 247156002904 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 247156002905 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 247156002906 glycogen branching enzyme; Provisional; Region: PRK05402 247156002907 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 247156002908 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 247156002909 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 247156002910 active site 247156002911 catalytic site [active] 247156002912 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 247156002913 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 247156002914 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 247156002915 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 247156002916 active site 247156002917 homodimer interface [polypeptide binding]; other site 247156002918 catalytic site [active] 247156002919 acceptor binding site [chemical binding]; other site 247156002920 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 247156002921 putative homodimer interface [polypeptide binding]; other site 247156002922 putative active site pocket [active] 247156002923 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 247156002924 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 247156002925 Protein of unknown function (DUF3754); Region: DUF3754; pfam12576 247156002926 DoxX; Region: DoxX; pfam07681 247156002927 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 247156002928 DEAD/DEAH box helicase; Region: DEAD; pfam00270 247156002929 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 247156002930 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 247156002931 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 247156002932 Isochorismatase family; Region: Isochorismatase; pfam00857 247156002933 catalytic triad [active] 247156002934 metal binding site [ion binding]; metal-binding site 247156002935 conserved cis-peptide bond; other site 247156002936 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 247156002937 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 247156002938 active site 247156002939 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 247156002940 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 247156002941 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 247156002942 putative active site pocket [active] 247156002943 cleavage site 247156002944 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 247156002945 MPN+ (JAMM) motif; other site 247156002946 Zinc-binding site [ion binding]; other site 247156002947 Ubiquitin-like proteins; Region: UBQ; cl00155 247156002948 charged pocket; other site 247156002949 hydrophobic patch; other site 247156002950 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 247156002951 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 247156002952 dimer interface [polypeptide binding]; other site 247156002953 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156002954 catalytic residue [active] 247156002955 YCII-related domain; Region: YCII; cl00999 247156002956 Rhomboid family; Region: Rhomboid; cl11446 247156002957 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 247156002958 ribonuclease PH; Reviewed; Region: rph; PRK00173 247156002959 Ribonuclease PH; Region: RNase_PH_bact; cd11362 247156002960 hexamer interface [polypeptide binding]; other site 247156002961 active site 247156002962 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 247156002963 active site 247156002964 dimerization interface [polypeptide binding]; other site 247156002965 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 247156002966 Glucitol operon activator protein (GutM); Region: GutM; cl01890 247156002967 short chain dehydrogenase; Provisional; Region: PRK06197 247156002968 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 247156002969 putative NAD(P) binding site [chemical binding]; other site 247156002970 active site 247156002971 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156002972 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156002973 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 247156002974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156002975 putative substrate translocation pore; other site 247156002976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156002977 Predicted transcriptional regulators [Transcription]; Region: COG1695 247156002978 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 247156002979 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 247156002980 hypothetical protein; Provisional; Region: PRK07236 247156002981 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 247156002982 Condensation domain; Region: Condensation; pfam00668 247156002983 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156002984 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 247156002985 acyl-activating enzyme (AAE) consensus motif; other site 247156002986 AMP binding site [chemical binding]; other site 247156002987 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156002988 Condensation domain; Region: Condensation; pfam00668 247156002989 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 247156002990 Condensation domain; Region: Condensation; pfam00668 247156002991 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 247156002992 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156002993 acyl-activating enzyme (AAE) consensus motif; other site 247156002994 AMP binding site [chemical binding]; other site 247156002995 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156002996 Condensation domain; Region: Condensation; pfam00668 247156002997 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 247156002998 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 247156002999 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156003000 acyl-activating enzyme (AAE) consensus motif; other site 247156003001 AMP binding site [chemical binding]; other site 247156003002 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156003003 Condensation domain; Region: Condensation; pfam00668 247156003004 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 247156003005 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156003006 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 247156003007 Walker A/P-loop; other site 247156003008 ATP binding site [chemical binding]; other site 247156003009 Q-loop/lid; other site 247156003010 ABC transporter signature motif; other site 247156003011 Walker B; other site 247156003012 D-loop; other site 247156003013 H-loop/switch region; other site 247156003014 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 247156003015 ABC-2 type transporter; Region: ABC2_membrane; cl17235 247156003016 ABC-2 type transporter; Region: ABC2_membrane; cl17235 247156003017 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 247156003018 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 247156003019 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 247156003020 PhoU domain; Region: PhoU; pfam01895 247156003021 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 247156003022 Permease; Region: Permease; pfam02405 247156003023 Permease; Region: Permease; pfam02405 247156003024 mce related protein; Region: MCE; pfam02470 247156003025 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 247156003026 mce related protein; Region: MCE; pfam02470 247156003027 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 247156003028 mce related protein; Region: MCE; pfam02470 247156003029 mce related protein; Region: MCE; pfam02470 247156003030 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 247156003031 mce related protein; Region: MCE; pfam02470 247156003032 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 247156003033 mce related protein; Region: MCE; pfam02470 247156003034 Protein of unknown function (DUF418); Region: DUF418; pfam04235 247156003035 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 247156003036 CCC1-related family of proteins; Region: CCC1_like; cl00278 247156003037 Putative esterase; Region: Esterase; pfam00756 247156003038 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 247156003039 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 247156003040 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 247156003041 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 247156003042 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 247156003043 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 247156003044 ATPase; Provisional; Region: PRK13764 247156003045 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 247156003046 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 247156003047 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 247156003048 DNA binding residues [nucleotide binding] 247156003049 drug binding residues [chemical binding]; other site 247156003050 dimer interface [polypeptide binding]; other site 247156003051 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 247156003052 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 247156003053 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 247156003054 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 247156003055 PAS domain; Region: PAS_9; pfam13426 247156003056 putative active site [active] 247156003057 heme pocket [chemical binding]; other site 247156003058 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 247156003059 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 247156003060 metal binding site [ion binding]; metal-binding site 247156003061 active site 247156003062 I-site; other site 247156003063 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 247156003064 Cytochrome P450; Region: p450; cl12078 247156003065 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 247156003066 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 247156003067 Uncharacterized conserved protein [Function unknown]; Region: COG5361 247156003068 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 247156003069 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 247156003070 Protein of unknown function DUF72; Region: DUF72; pfam01904 247156003071 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156003072 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156003073 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156003074 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156003075 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 247156003076 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 247156003077 FAD binding domain; Region: FAD_binding_2; pfam00890 247156003078 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 247156003079 Transcriptional regulator [Transcription]; Region: IclR; COG1414 247156003080 Bacterial transcriptional regulator; Region: IclR; pfam01614 247156003081 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 247156003082 substrate binding pocket [chemical binding]; other site 247156003083 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 247156003084 membrane-bound complex binding site; other site 247156003085 hinge residues; other site 247156003086 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 247156003087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 247156003088 dimer interface [polypeptide binding]; other site 247156003089 conserved gate region; other site 247156003090 putative PBP binding loops; other site 247156003091 ABC-ATPase subunit interface; other site 247156003092 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 247156003093 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156003094 Walker A/P-loop; other site 247156003095 ATP binding site [chemical binding]; other site 247156003096 Q-loop/lid; other site 247156003097 ABC transporter signature motif; other site 247156003098 Walker B; other site 247156003099 D-loop; other site 247156003100 H-loop/switch region; other site 247156003101 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 247156003102 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 247156003103 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 247156003104 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 247156003105 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 247156003106 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 247156003107 Zn2+ binding site [ion binding]; other site 247156003108 intersubunit interface [polypeptide binding]; other site 247156003109 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 247156003110 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 247156003111 substrate binding pocket [chemical binding]; other site 247156003112 membrane-bound complex binding site; other site 247156003113 hinge residues; other site 247156003114 PAS fold; Region: PAS; pfam00989 247156003115 PAS domain; Region: PAS; smart00091 247156003116 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 247156003117 PAS domain; Region: PAS_9; pfam13426 247156003118 putative active site [active] 247156003119 heme pocket [chemical binding]; other site 247156003120 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 247156003121 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 247156003122 metal binding site [ion binding]; metal-binding site 247156003123 active site 247156003124 I-site; other site 247156003125 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 247156003126 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 247156003127 DNA binding residues [nucleotide binding] 247156003128 putative dimer interface [polypeptide binding]; other site 247156003129 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 247156003130 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 247156003131 Competence-damaged protein; Region: CinA; pfam02464 247156003132 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 247156003133 DNA-binding site [nucleotide binding]; DNA binding site 247156003134 RNA-binding motif; other site 247156003135 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 247156003136 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 247156003137 dimer interface [polypeptide binding]; other site 247156003138 active site 247156003139 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 247156003140 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 247156003141 DNA binding residues [nucleotide binding] 247156003142 dimerization interface [polypeptide binding]; other site 247156003143 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 247156003144 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 247156003145 Predicted membrane protein [Function unknown]; Region: COG2246 247156003146 GtrA-like protein; Region: GtrA; pfam04138 247156003147 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 247156003148 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 247156003149 Amidase; Region: Amidase; cl11426 247156003150 Clp protease; Region: CLP_protease; pfam00574 247156003151 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 247156003152 oligomer interface [polypeptide binding]; other site 247156003153 active site residues [active] 247156003154 Clp protease; Region: CLP_protease; pfam00574 247156003155 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 247156003156 oligomer interface [polypeptide binding]; other site 247156003157 active site residues [active] 247156003158 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156003159 sequence-specific DNA binding site [nucleotide binding]; other site 247156003160 salt bridge; other site 247156003161 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 247156003162 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 247156003163 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 247156003164 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 247156003165 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 247156003166 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 247156003167 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 247156003168 enoyl-CoA hydratase; Provisional; Region: PRK08260 247156003169 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 247156003170 substrate binding site [chemical binding]; other site 247156003171 oxyanion hole (OAH) forming residues; other site 247156003172 trimer interface [polypeptide binding]; other site 247156003173 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 247156003174 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 247156003175 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 247156003176 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 247156003177 iron-sulfur cluster [ion binding]; other site 247156003178 [2Fe-2S] cluster binding site [ion binding]; other site 247156003179 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 247156003180 Hemerythrin-like domain; Region: Hr-like; cd12108 247156003181 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 247156003182 dimanganese center [ion binding]; other site 247156003183 Cutinase; Region: Cutinase; pfam01083 247156003184 YaeQ protein; Region: YaeQ; pfam07152 247156003185 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 247156003186 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 247156003187 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 247156003188 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156003189 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156003190 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 247156003191 CAAX protease self-immunity; Region: Abi; pfam02517 247156003192 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 247156003193 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156003194 NAD(P) binding site [chemical binding]; other site 247156003195 active site 247156003196 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 247156003197 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 247156003198 D-pathway; other site 247156003199 Putative ubiquinol binding site [chemical binding]; other site 247156003200 Low-spin heme (heme b) binding site [chemical binding]; other site 247156003201 Putative water exit pathway; other site 247156003202 Binuclear center (heme o3/CuB) [ion binding]; other site 247156003203 K-pathway; other site 247156003204 Putative proton exit pathway; other site 247156003205 Phosphotransferase enzyme family; Region: APH; pfam01636 247156003206 Ecdysteroid kinase; Region: EcKinase; cl17738 247156003207 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 247156003208 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 247156003209 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 247156003210 NAD binding site [chemical binding]; other site 247156003211 catalytic Zn binding site [ion binding]; other site 247156003212 substrate binding site [chemical binding]; other site 247156003213 structural Zn binding site [ion binding]; other site 247156003214 MoxR-like ATPases [General function prediction only]; Region: COG0714 247156003215 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 247156003216 Walker A motif; other site 247156003217 ATP binding site [chemical binding]; other site 247156003218 Walker B motif; other site 247156003219 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 247156003220 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156003221 active site 247156003222 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 247156003223 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 247156003224 active site 247156003225 dimer interface [polypeptide binding]; other site 247156003226 non-prolyl cis peptide bond; other site 247156003227 insertion regions; other site 247156003228 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 247156003229 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 247156003230 active site 247156003231 non-prolyl cis peptide bond; other site 247156003232 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 247156003233 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 247156003234 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 247156003235 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 247156003236 NAD(P) binding site [chemical binding]; other site 247156003237 catalytic residues [active] 247156003238 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 247156003239 Amidase; Region: Amidase; pfam01425 247156003240 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 247156003241 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 247156003242 FAD binding pocket [chemical binding]; other site 247156003243 FAD binding motif [chemical binding]; other site 247156003244 phosphate binding motif [ion binding]; other site 247156003245 beta-alpha-beta structure motif; other site 247156003246 NAD binding pocket [chemical binding]; other site 247156003247 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156003248 NADH(P)-binding; Region: NAD_binding_10; pfam13460 247156003249 NAD(P) binding site [chemical binding]; other site 247156003250 active site 247156003251 Predicted transcriptional regulators [Transcription]; Region: COG1733 247156003252 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 247156003253 Transcriptional regulator [Transcription]; Region: LysR; COG0583 247156003254 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 247156003255 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 247156003256 putative substrate binding pocket [chemical binding]; other site 247156003257 dimerization interface [polypeptide binding]; other site 247156003258 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 247156003259 Cytochrome P450; Region: p450; cl12078 247156003260 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 247156003261 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 247156003262 catalytic loop [active] 247156003263 iron binding site [ion binding]; other site 247156003264 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 247156003265 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 247156003266 Cytochrome P450; Region: p450; cl12078 247156003267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156003268 metabolite-proton symporter; Region: 2A0106; TIGR00883 247156003269 putative substrate translocation pore; other site 247156003270 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156003271 AAA ATPase domain; Region: AAA_16; pfam13191 247156003272 Predicted ATPase [General function prediction only]; Region: COG3903 247156003273 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 247156003274 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 247156003275 DNA binding residues [nucleotide binding] 247156003276 dimerization interface [polypeptide binding]; other site 247156003277 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 247156003278 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 247156003279 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 247156003280 NAD(P) binding site [chemical binding]; other site 247156003281 catalytic residues [active] 247156003282 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 247156003283 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 247156003284 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 247156003285 NAD binding site [chemical binding]; other site 247156003286 catalytic Zn binding site [ion binding]; other site 247156003287 substrate binding site [chemical binding]; other site 247156003288 structural Zn binding site [ion binding]; other site 247156003289 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 247156003290 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 247156003291 DNA binding residues [nucleotide binding] 247156003292 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 247156003293 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 247156003294 DNA-binding site [nucleotide binding]; DNA binding site 247156003295 UTRA domain; Region: UTRA; pfam07702 247156003296 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 247156003297 urocanate hydratase; Provisional; Region: PRK05414 247156003298 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 247156003299 active sites [active] 247156003300 tetramer interface [polypeptide binding]; other site 247156003301 putative proline-specific permease; Provisional; Region: proY; PRK10580 247156003302 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156003303 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156003304 active site 247156003305 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 247156003306 CoA-transferase family III; Region: CoA_transf_3; pfam02515 247156003307 Transcriptional regulator [Transcription]; Region: IclR; COG1414 247156003308 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 247156003309 Bacterial transcriptional regulator; Region: IclR; pfam01614 247156003310 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 247156003311 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 247156003312 Na binding site [ion binding]; other site 247156003313 imidazolonepropionase; Provisional; Region: PRK14085 247156003314 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 247156003315 active site 247156003316 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 247156003317 putative active site [active] 247156003318 putative metal binding site [ion binding]; other site 247156003319 putative indolepyruvate oxidoreductase subunit B; Reviewed; Region: PRK08312 247156003320 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 247156003321 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits [Energy production and conversion]; Region: COG4231 247156003322 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 247156003323 dimer interface [polypeptide binding]; other site 247156003324 PYR/PP interface [polypeptide binding]; other site 247156003325 TPP binding site [chemical binding]; other site 247156003326 substrate binding site [chemical binding]; other site 247156003327 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 247156003328 TPP-binding site; other site 247156003329 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 247156003330 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 247156003331 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 247156003332 Cupin domain; Region: Cupin_2; cl17218 247156003333 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 247156003334 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 247156003335 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 247156003336 homotrimer interaction site [polypeptide binding]; other site 247156003337 putative active site [active] 247156003338 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 247156003339 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 247156003340 acyl-activating enzyme (AAE) consensus motif; other site 247156003341 AMP binding site [chemical binding]; other site 247156003342 active site 247156003343 CoA binding site [chemical binding]; other site 247156003344 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 247156003345 hypothetical protein; Provisional; Region: PRK07236 247156003346 hypothetical protein; Provisional; Region: PRK07236 247156003347 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 247156003348 active site 247156003349 FMN binding site [chemical binding]; other site 247156003350 substrate binding site [chemical binding]; other site 247156003351 homotetramer interface [polypeptide binding]; other site 247156003352 catalytic residue [active] 247156003353 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 247156003354 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 247156003355 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 247156003356 short chain dehydrogenase; Provisional; Region: PRK08265 247156003357 classical (c) SDRs; Region: SDR_c; cd05233 247156003358 NAD(P) binding site [chemical binding]; other site 247156003359 active site 247156003360 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 247156003361 PaaX-like protein; Region: PaaX; pfam07848 247156003362 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 247156003363 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 247156003364 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 247156003365 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 247156003366 active site 247156003367 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 247156003368 catalytic triad [active] 247156003369 dimer interface [polypeptide binding]; other site 247156003370 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156003371 Part of AAA domain; Region: AAA_19; pfam13245 247156003372 AAA domain; Region: AAA_11; pfam13086 247156003373 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 247156003374 AAA domain; Region: AAA_12; pfam13087 247156003375 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 247156003376 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 247156003377 synthetase active site [active] 247156003378 NTP binding site [chemical binding]; other site 247156003379 metal binding site [ion binding]; metal-binding site 247156003380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156003381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156003382 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 247156003383 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 247156003384 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 247156003385 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 247156003386 active site 2 [active] 247156003387 active site 1 [active] 247156003388 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 247156003389 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 247156003390 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 247156003391 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 247156003392 putative NAD(P) binding site [chemical binding]; other site 247156003393 active site 247156003394 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 247156003395 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 247156003396 active site 247156003397 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 247156003398 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156003399 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156003400 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 247156003401 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 247156003402 ABC-2 type transporter; Region: ABC2_membrane; cl17235 247156003403 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156003404 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 247156003405 Walker A/P-loop; other site 247156003406 ATP binding site [chemical binding]; other site 247156003407 Q-loop/lid; other site 247156003408 ABC transporter signature motif; other site 247156003409 Walker B; other site 247156003410 D-loop; other site 247156003411 H-loop/switch region; other site 247156003412 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156003413 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 247156003414 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 247156003415 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 247156003416 catalytic triad [active] 247156003417 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 247156003418 Excalibur calcium-binding domain; Region: Excalibur; smart00894 247156003419 Transcriptional regulators [Transcription]; Region: MarR; COG1846 247156003420 MarR family; Region: MarR_2; pfam12802 247156003421 MarR family; Region: MarR_2; cl17246 247156003422 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 247156003423 N-acetyl-D-glucosamine binding site [chemical binding]; other site 247156003424 catalytic residue [active] 247156003425 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 247156003426 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 247156003427 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 247156003428 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 247156003429 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 247156003430 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 247156003431 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 247156003432 tetrameric interface [polypeptide binding]; other site 247156003433 NAD binding site [chemical binding]; other site 247156003434 catalytic residues [active] 247156003435 substrate binding site [chemical binding]; other site 247156003436 acyl-CoA synthetase; Validated; Region: PRK08162 247156003437 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 247156003438 acyl-activating enzyme (AAE) consensus motif; other site 247156003439 putative active site [active] 247156003440 AMP binding site [chemical binding]; other site 247156003441 putative CoA binding site [chemical binding]; other site 247156003442 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 247156003443 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 247156003444 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 247156003445 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 247156003446 NAD binding site [chemical binding]; other site 247156003447 catalytic Zn binding site [ion binding]; other site 247156003448 substrate binding site [chemical binding]; other site 247156003449 structural Zn binding site [ion binding]; other site 247156003450 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 247156003451 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 247156003452 tellurium resistance terB-like protein; Region: terB_like; cl11965 247156003453 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 247156003454 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 247156003455 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 247156003456 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 247156003457 catalytic residue [active] 247156003458 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 247156003459 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 247156003460 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 247156003461 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 247156003462 SnoaL-like domain; Region: SnoaL_4; pfam13577 247156003463 short chain dehydrogenase; Provisional; Region: PRK08303 247156003464 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156003465 NAD(P) binding site [chemical binding]; other site 247156003466 active site 247156003467 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 247156003468 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 247156003469 catalytic site [active] 247156003470 putative active site [active] 247156003471 putative substrate binding site [chemical binding]; other site 247156003472 dimer interface [polypeptide binding]; other site 247156003473 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 247156003474 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 247156003475 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156003476 NAD(P) binding site [chemical binding]; other site 247156003477 active site 247156003478 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 247156003479 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 247156003480 active site 247156003481 FMN binding site [chemical binding]; other site 247156003482 2,4-decadienoyl-CoA binding site; other site 247156003483 catalytic residue [active] 247156003484 4Fe-4S cluster binding site [ion binding]; other site 247156003485 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 247156003486 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 247156003487 Predicted transcriptional regulators [Transcription]; Region: COG1695 247156003488 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 247156003489 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 247156003490 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 247156003491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156003492 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 247156003493 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156003494 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 247156003495 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 247156003496 FAD binding pocket [chemical binding]; other site 247156003497 FAD binding motif [chemical binding]; other site 247156003498 phosphate binding motif [ion binding]; other site 247156003499 beta-alpha-beta structure motif; other site 247156003500 NAD binding pocket [chemical binding]; other site 247156003501 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 247156003502 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 247156003503 catalytic loop [active] 247156003504 iron binding site [ion binding]; other site 247156003505 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 247156003506 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 247156003507 putative di-iron ligands [ion binding]; other site 247156003508 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 247156003509 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 247156003510 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 247156003511 inhibitor-cofactor binding pocket; inhibition site 247156003512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156003513 catalytic residue [active] 247156003514 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 247156003515 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 247156003516 dimerization interface [polypeptide binding]; other site 247156003517 DPS ferroxidase diiron center [ion binding]; other site 247156003518 ion pore; other site 247156003519 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 247156003520 nudix motif; other site 247156003521 Copper resistance protein D; Region: CopD; cl00563 247156003522 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 247156003523 threonine dehydratase; Provisional; Region: PRK08246 247156003524 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 247156003525 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 247156003526 catalytic residue [active] 247156003527 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 247156003528 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 247156003529 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 247156003530 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 247156003531 ABC transporter; Region: ABC_tran_2; pfam12848 247156003532 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 247156003533 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 247156003534 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 247156003535 active site 247156003536 AzlC protein; Region: AzlC; cl00570 247156003537 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 247156003538 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156003539 non-specific DNA binding site [nucleotide binding]; other site 247156003540 salt bridge; other site 247156003541 sequence-specific DNA binding site [nucleotide binding]; other site 247156003542 Cupin domain; Region: Cupin_2; cl17218 247156003543 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 247156003544 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 247156003545 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 247156003546 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 247156003547 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 247156003548 active site 247156003549 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 247156003550 apolar tunnel; other site 247156003551 heme binding site [chemical binding]; other site 247156003552 dimerization interface [polypeptide binding]; other site 247156003553 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 247156003554 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 247156003555 active site 247156003556 catalytic site [active] 247156003557 Repair protein; Region: Repair_PSII; pfam04536 247156003558 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 247156003559 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 247156003560 Zn binding site [ion binding]; other site 247156003561 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 247156003562 ATP binding site [chemical binding]; other site 247156003563 active site 247156003564 substrate binding site [chemical binding]; other site 247156003565 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 247156003566 nudix motif; other site 247156003567 PQQ-like domain; Region: PQQ_2; pfam13360 247156003568 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 247156003569 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 247156003570 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 247156003571 DNA binding residues [nucleotide binding] 247156003572 YCII-related domain; Region: YCII; cl00999 247156003573 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 247156003574 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 247156003575 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 247156003576 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 247156003577 catalytic residues [active] 247156003578 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 247156003579 Peptidase family M48; Region: Peptidase_M48; pfam01435 247156003580 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 247156003581 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 247156003582 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 247156003583 putative DNA binding site [nucleotide binding]; other site 247156003584 catalytic residue [active] 247156003585 putative H2TH interface [polypeptide binding]; other site 247156003586 putative catalytic residues [active] 247156003587 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 247156003588 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 247156003589 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 247156003590 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 247156003591 metal binding site [ion binding]; metal-binding site 247156003592 active site 247156003593 I-site; other site 247156003594 putative phosphoketolase; Provisional; Region: PRK05261 247156003595 XFP N-terminal domain; Region: XFP_N; pfam09364 247156003596 XFP C-terminal domain; Region: XFP_C; pfam09363 247156003597 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 247156003598 trigger factor; Provisional; Region: tig; PRK01490 247156003599 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 247156003600 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 247156003601 Clp protease; Region: CLP_protease; pfam00574 247156003602 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 247156003603 oligomer interface [polypeptide binding]; other site 247156003604 active site residues [active] 247156003605 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 247156003606 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 247156003607 oligomer interface [polypeptide binding]; other site 247156003608 active site residues [active] 247156003609 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 247156003610 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 247156003611 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 247156003612 Walker A motif; other site 247156003613 ATP binding site [chemical binding]; other site 247156003614 Walker B motif; other site 247156003615 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 247156003616 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 247156003617 anti sigma factor interaction site; other site 247156003618 regulatory phosphorylation site [posttranslational modification]; other site 247156003619 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 247156003620 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 247156003621 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 247156003622 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 247156003623 putative molybdopterin cofactor binding site [chemical binding]; other site 247156003624 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 247156003625 putative molybdopterin cofactor binding site; other site 247156003626 FHA domain; Region: FHA; pfam00498 247156003627 phosphopeptide binding site; other site 247156003628 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 247156003629 Coenzyme A binding pocket [chemical binding]; other site 247156003630 glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369 247156003631 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156003632 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156003633 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 247156003634 FAD binding domain; Region: FAD_binding_4; pfam01565 247156003635 diacylglycerol kinase; Reviewed; Region: PRK11914 247156003636 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 247156003637 AAA domain; Region: AAA_33; pfam13671 247156003638 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 247156003639 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 247156003640 active site 247156003641 HIGH motif; other site 247156003642 nucleotide binding site [chemical binding]; other site 247156003643 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 247156003644 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 247156003645 active site 247156003646 KMSKS motif; other site 247156003647 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 247156003648 tRNA binding surface [nucleotide binding]; other site 247156003649 anticodon binding site; other site 247156003650 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 247156003651 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 247156003652 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 247156003653 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 247156003654 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 247156003655 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 247156003656 active site 247156003657 multimer interface [polypeptide binding]; other site 247156003658 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 247156003659 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 247156003660 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 247156003661 homodimer interface [polypeptide binding]; other site 247156003662 oligonucleotide binding site [chemical binding]; other site 247156003663 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 247156003664 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 247156003665 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 247156003666 GTPase CgtA; Reviewed; Region: obgE; PRK12296 247156003667 GTP1/OBG; Region: GTP1_OBG; pfam01018 247156003668 Obg GTPase; Region: Obg; cd01898 247156003669 G1 box; other site 247156003670 GTP/Mg2+ binding site [chemical binding]; other site 247156003671 Switch I region; other site 247156003672 G2 box; other site 247156003673 G3 box; other site 247156003674 Switch II region; other site 247156003675 G4 box; other site 247156003676 G5 box; other site 247156003677 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 247156003678 gamma-glutamyl kinase; Provisional; Region: PRK05429 247156003679 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 247156003680 nucleotide binding site [chemical binding]; other site 247156003681 homotetrameric interface [polypeptide binding]; other site 247156003682 putative phosphate binding site [ion binding]; other site 247156003683 putative allosteric binding site; other site 247156003684 PUA domain; Region: PUA; pfam01472 247156003685 Beta-lactamase; Region: Beta-lactamase; pfam00144 247156003686 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 247156003687 First Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt1; cd04772 247156003688 DNA binding residues [nucleotide binding] 247156003689 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 247156003690 putative dimer interface [polypeptide binding]; other site 247156003691 Second Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt2; cd04773 247156003692 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 247156003693 DNA binding residues [nucleotide binding] 247156003694 putative dimer interface [polypeptide binding]; other site 247156003695 EspG family; Region: ESX-1_EspG; pfam14011 247156003696 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156003697 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156003698 active site 247156003699 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156003700 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156003701 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 247156003702 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 247156003703 putative ligand binding site [chemical binding]; other site 247156003704 putative NAD binding site [chemical binding]; other site 247156003705 catalytic site [active] 247156003706 Predicted eukaryotic-type DNA primase [DNA replication, recombination, and repair]; Region: COG3285 247156003707 nucleotide binding site [chemical binding]; other site 247156003708 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 247156003709 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 247156003710 ATP binding site [chemical binding]; other site 247156003711 putative Mg++ binding site [ion binding]; other site 247156003712 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 247156003713 nucleotide binding region [chemical binding]; other site 247156003714 ATP-binding site [chemical binding]; other site 247156003715 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 247156003716 hypothetical protein; Reviewed; Region: PRK09588 247156003717 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 247156003718 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 247156003719 substrate binding site [chemical binding]; other site 247156003720 dimer interface [polypeptide binding]; other site 247156003721 ATP binding site [chemical binding]; other site 247156003722 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 247156003723 putative catalytic cysteine [active] 247156003724 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 247156003725 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 247156003726 Walker A motif; other site 247156003727 ATP binding site [chemical binding]; other site 247156003728 Walker B motif; other site 247156003729 arginine finger; other site 247156003730 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 247156003731 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 247156003732 metal ion-dependent adhesion site (MIDAS); other site 247156003733 Protein of unknown function (DUF419); Region: DUF419; pfam04237 247156003734 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 247156003735 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 247156003736 active site 247156003737 (T/H)XGH motif; other site 247156003738 Oligomerisation domain; Region: Oligomerisation; pfam02410 247156003739 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 247156003740 catalytic core [active] 247156003741 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 247156003742 active site 247156003743 catalytic triad [active] 247156003744 oxyanion hole [active] 247156003745 EDD domain protein, DegV family; Region: DegV; TIGR00762 247156003746 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 247156003747 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 247156003748 active site 247156003749 dimer interface [polypeptide binding]; other site 247156003750 motif 1; other site 247156003751 motif 2; other site 247156003752 motif 3; other site 247156003753 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 247156003754 anticodon binding site; other site 247156003755 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 247156003756 Helix-hairpin-helix motif; Region: HHH; pfam00633 247156003757 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 247156003758 Competence protein; Region: Competence; pfam03772 247156003759 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 247156003760 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 247156003761 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 247156003762 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 247156003763 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 247156003764 oxidoreductase; Provisional; Region: PRK12743 247156003765 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156003766 D-loop; other site 247156003767 H-loop/switch region; other site 247156003768 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 247156003769 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 247156003770 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 247156003771 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 247156003772 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 247156003773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 247156003774 hypothetical protein; Reviewed; Region: PRK07914 247156003775 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 247156003776 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 247156003777 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 247156003778 amphipathic channel; other site 247156003779 Asn-Pro-Ala signature motifs; other site 247156003780 PemK-like protein; Region: PemK; pfam02452 247156003781 GTP-binding protein LepA; Provisional; Region: PRK05433 247156003782 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 247156003783 G1 box; other site 247156003784 putative GEF interaction site [polypeptide binding]; other site 247156003785 GTP/Mg2+ binding site [chemical binding]; other site 247156003786 Switch I region; other site 247156003787 G2 box; other site 247156003788 G3 box; other site 247156003789 Switch II region; other site 247156003790 G4 box; other site 247156003791 G5 box; other site 247156003792 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 247156003793 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 247156003794 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 247156003795 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 247156003796 Dynamin family; Region: Dynamin_N; pfam00350 247156003797 G1 box; other site 247156003798 GTP/Mg2+ binding site [chemical binding]; other site 247156003799 G2 box; other site 247156003800 Switch I region; other site 247156003801 G3 box; other site 247156003802 Switch II region; other site 247156003803 G4 box; other site 247156003804 G5 box; other site 247156003805 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 247156003806 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 247156003807 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 247156003808 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 247156003809 sulfate transport protein; Provisional; Region: cysT; CHL00187 247156003810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 247156003811 dimer interface [polypeptide binding]; other site 247156003812 conserved gate region; other site 247156003813 putative PBP binding loops; other site 247156003814 ABC-ATPase subunit interface; other site 247156003815 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 247156003816 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 247156003817 dimer interface [polypeptide binding]; other site 247156003818 conserved gate region; other site 247156003819 putative PBP binding loops; other site 247156003820 ABC-ATPase subunit interface; other site 247156003821 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 247156003822 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 247156003823 Walker A/P-loop; other site 247156003824 ATP binding site [chemical binding]; other site 247156003825 Q-loop/lid; other site 247156003826 ABC transporter signature motif; other site 247156003827 Walker B; other site 247156003828 D-loop; other site 247156003829 H-loop/switch region; other site 247156003830 TOBE domain; Region: TOBE; pfam03459 247156003831 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 247156003832 Ferredoxin [Energy production and conversion]; Region: COG1146 247156003833 4Fe-4S binding domain; Region: Fer4; pfam00037 247156003834 ferredoxin-NADP+ reductase; Region: PLN02852 247156003835 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 247156003836 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 247156003837 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 247156003838 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 247156003839 active site 247156003840 catalytic triad [active] 247156003841 oxyanion hole [active] 247156003842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156003843 putative substrate translocation pore; other site 247156003844 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156003845 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 247156003846 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 247156003847 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 247156003848 putative active site [active] 247156003849 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 247156003850 putative active site [active] 247156003851 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 247156003852 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 247156003853 CysD dimerization site [polypeptide binding]; other site 247156003854 G1 box; other site 247156003855 putative GEF interaction site [polypeptide binding]; other site 247156003856 GTP/Mg2+ binding site [chemical binding]; other site 247156003857 Switch I region; other site 247156003858 G2 box; other site 247156003859 G3 box; other site 247156003860 Switch II region; other site 247156003861 G4 box; other site 247156003862 G5 box; other site 247156003863 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 247156003864 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 247156003865 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 247156003866 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 247156003867 Active Sites [active] 247156003868 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 247156003869 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 247156003870 Active Sites [active] 247156003871 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 247156003872 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 247156003873 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 247156003874 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 247156003875 coproporphyrinogen III oxidase; Validated; Region: PRK05628 247156003876 HemN C-terminal domain; Region: HemN_C; pfam06969 247156003877 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 247156003878 HTH domain; Region: HTH_11; cl17392 247156003879 chaperone protein DnaJ; Provisional; Region: PRK14278 247156003880 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 247156003881 HSP70 interaction site [polypeptide binding]; other site 247156003882 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 247156003883 Zn binding sites [ion binding]; other site 247156003884 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 247156003885 dimer interface [polypeptide binding]; other site 247156003886 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 247156003887 RNA methyltransferase, RsmE family; Region: TIGR00046 247156003888 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 247156003889 MarR family; Region: MarR; pfam01047 247156003890 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 247156003891 SnoaL-like domain; Region: SnoaL_3; pfam13474 247156003892 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156003893 Major Facilitator Superfamily; Region: MFS_1; pfam07690 247156003894 putative substrate translocation pore; other site 247156003895 Transcriptional regulator [Transcription]; Region: LysR; COG0583 247156003896 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 247156003897 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 247156003898 putative dimerization interface [polypeptide binding]; other site 247156003899 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 247156003900 PhoH-like protein; Region: PhoH; pfam02562 247156003901 metal-binding heat shock protein; Provisional; Region: PRK00016 247156003902 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 247156003903 Domain of unknown function DUF21; Region: DUF21; pfam01595 247156003904 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 247156003905 Transporter associated domain; Region: CorC_HlyC; smart01091 247156003906 GTPase Era; Reviewed; Region: era; PRK00089 247156003907 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 247156003908 G1 box; other site 247156003909 GTP/Mg2+ binding site [chemical binding]; other site 247156003910 Switch I region; other site 247156003911 G2 box; other site 247156003912 Switch II region; other site 247156003913 G3 box; other site 247156003914 G4 box; other site 247156003915 G5 box; other site 247156003916 KH domain; Region: KH_2; pfam07650 247156003917 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 247156003918 putative ligand binding site [chemical binding]; other site 247156003919 acyl-CoA synthetase; Validated; Region: PRK05850 247156003920 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 247156003921 acyl-activating enzyme (AAE) consensus motif; other site 247156003922 active site 247156003923 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 247156003924 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 247156003925 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 247156003926 active site 247156003927 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 247156003928 ABC1 family; Region: ABC1; cl17513 247156003929 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 247156003930 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 247156003931 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 247156003932 catalytic residue [active] 247156003933 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156003934 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156003935 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 247156003936 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 247156003937 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156003938 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 247156003939 Protein of unknown function (DUF3419); Region: DUF3419; pfam11899 247156003940 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 247156003941 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 247156003942 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 247156003943 intersubunit interface [polypeptide binding]; other site 247156003944 active site 247156003945 Zn2+ binding site [ion binding]; other site 247156003946 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 247156003947 Cupin domain; Region: Cupin_2; pfam07883 247156003948 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 247156003949 active site 247156003950 catalytic triad [active] 247156003951 oxyanion hole [active] 247156003952 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 247156003953 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 247156003954 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156003955 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 247156003956 Recombination protein O N terminal; Region: RecO_N; pfam11967 247156003957 Recombination protein O C terminal; Region: RecO_C; pfam02565 247156003958 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14829 247156003959 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 247156003960 catalytic residue [active] 247156003961 putative FPP diphosphate binding site; other site 247156003962 putative FPP binding hydrophobic cleft; other site 247156003963 dimer interface [polypeptide binding]; other site 247156003964 putative IPP diphosphate binding site; other site 247156003965 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156003966 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156003967 ferric uptake regulator; Provisional; Region: fur; PRK09462 247156003968 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 247156003969 metal binding site 2 [ion binding]; metal-binding site 247156003970 putative DNA binding helix; other site 247156003971 metal binding site 1 [ion binding]; metal-binding site 247156003972 dimer interface [polypeptide binding]; other site 247156003973 structural Zn2+ binding site [ion binding]; other site 247156003974 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 247156003975 dimerization interface [polypeptide binding]; other site 247156003976 putative DNA binding site [nucleotide binding]; other site 247156003977 putative Zn2+ binding site [ion binding]; other site 247156003978 glycyl-tRNA synthetase; Provisional; Region: PRK04173 247156003979 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 247156003980 motif 1; other site 247156003981 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 247156003982 active site 247156003983 motif 2; other site 247156003984 motif 3; other site 247156003985 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 247156003986 anticodon binding site; other site 247156003987 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 247156003988 acyltransferase PapA5; Provisional; Region: PRK09294 247156003989 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156003990 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156003991 Repair protein; Region: Repair_PSII; pfam04536 247156003992 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 247156003993 RibD C-terminal domain; Region: RibD_C; cl17279 247156003994 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 247156003995 Beta-lactamase; Region: Beta-lactamase; pfam00144 247156003996 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 247156003997 putative active site [active] 247156003998 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 247156003999 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 247156004000 Zn2+ binding site [ion binding]; other site 247156004001 Mg2+ binding site [ion binding]; other site 247156004002 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 247156004003 DNA primase; Validated; Region: dnaG; PRK05667 247156004004 CHC2 zinc finger; Region: zf-CHC2; pfam01807 247156004005 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 247156004006 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 247156004007 active site 247156004008 metal binding site [ion binding]; metal-binding site 247156004009 interdomain interaction site; other site 247156004010 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 247156004011 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 247156004012 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 247156004013 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156004014 non-specific DNA binding site [nucleotide binding]; other site 247156004015 salt bridge; other site 247156004016 sequence-specific DNA binding site [nucleotide binding]; other site 247156004017 Helix-turn-helix domain; Region: HTH_17; pfam12728 247156004018 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 247156004019 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 247156004020 Transcription factor WhiB; Region: Whib; pfam02467 247156004021 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 247156004022 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 247156004023 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 247156004024 active site 247156004025 GIY-YIG catalytic domain; Region: GIY-YIG; pfam01541 247156004026 active site 247156004027 GIY-YIG motif/motif A; other site 247156004028 catalytic site [active] 247156004029 metal binding site [ion binding]; metal-binding site 247156004030 Helix-turn-helix domain; Region: HTH_36; pfam13730 247156004031 AAA domain; Region: AAA_25; pfam13481 247156004032 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 247156004033 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 247156004034 Probable transposase; Region: OrfB_IS605; pfam01385 247156004035 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 247156004036 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 247156004037 DNA binding residues [nucleotide binding] 247156004038 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 247156004039 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 247156004040 Probable transposase; Region: OrfB_IS605; pfam01385 247156004041 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 247156004042 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 247156004043 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 247156004044 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 247156004045 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 247156004046 thioester formation/cholesterol transfer; other site 247156004047 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 247156004048 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 247156004049 Protein of unknown function (DUF2744); Region: DUF2744; pfam10910 247156004050 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 247156004051 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 247156004052 active site 247156004053 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 247156004054 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156004055 non-specific DNA binding site [nucleotide binding]; other site 247156004056 salt bridge; other site 247156004057 sequence-specific DNA binding site [nucleotide binding]; other site 247156004058 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 247156004059 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 247156004060 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 247156004061 active site 247156004062 DNA binding site [nucleotide binding] 247156004063 Int/Topo IB signature motif; other site 247156004064 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 247156004065 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 247156004066 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 247156004067 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 247156004068 Secretory lipase; Region: LIP; pfam03583 247156004069 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 247156004070 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 247156004071 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 247156004072 Soluble P-type ATPase [General function prediction only]; Region: COG4087 247156004073 K+-transporting ATPase, c chain; Region: KdpC; cl00944 247156004074 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 247156004075 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 247156004076 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 247156004077 Ligand Binding Site [chemical binding]; other site 247156004078 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 247156004079 dimer interface [polypeptide binding]; other site 247156004080 phosphorylation site [posttranslational modification] 247156004081 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 247156004082 ATP binding site [chemical binding]; other site 247156004083 Mg2+ binding site [ion binding]; other site 247156004084 G-X-G motif; other site 247156004085 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 247156004086 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 247156004087 active site 247156004088 phosphorylation site [posttranslational modification] 247156004089 intermolecular recognition site; other site 247156004090 dimerization interface [polypeptide binding]; other site 247156004091 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 247156004092 DNA binding site [nucleotide binding] 247156004093 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 247156004094 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 247156004095 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 247156004096 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 247156004097 Uncharacterized conserved protein [Function unknown]; Region: COG4278 247156004098 Domain of unknown function (DUF385); Region: DUF385; pfam04075 247156004099 TIGR04255 family protein; Region: sporadTIGR04255 247156004100 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 247156004101 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 247156004102 active site 247156004103 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 247156004104 active site 247156004105 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 247156004106 TAP-like protein; Region: Abhydrolase_4; pfam08386 247156004107 Helix-turn-helix domain; Region: HTH_18; pfam12833 247156004108 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 247156004109 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 247156004110 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 247156004111 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 247156004112 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 247156004113 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 247156004114 potential catalytic triad [active] 247156004115 conserved cys residue [active] 247156004116 MspA; Region: MspA; pfam09203 247156004117 MspA; Region: MspA; pfam09203 247156004118 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 247156004119 MarR family; Region: MarR_2; pfam12802 247156004120 Transcriptional regulators [Transcription]; Region: MarR; COG1846 247156004121 Predicted integral membrane protein (DUF2269); Region: DUF2269; cl02335 247156004122 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 247156004123 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 247156004124 putative metal binding site [ion binding]; other site 247156004125 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 247156004126 metal ion-dependent adhesion site (MIDAS); other site 247156004127 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156004128 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156004129 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 247156004130 putative metal binding site [ion binding]; other site 247156004131 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 247156004132 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 247156004133 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 247156004134 active site 247156004135 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 247156004136 Glutamine amidotransferase class-I; Region: GATase; pfam00117 247156004137 glutamine binding [chemical binding]; other site 247156004138 catalytic triad [active] 247156004139 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 247156004140 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 247156004141 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 247156004142 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 247156004143 Phosphotransferase enzyme family; Region: APH; pfam01636 247156004144 putative active site [active] 247156004145 putative substrate binding site [chemical binding]; other site 247156004146 ATP binding site [chemical binding]; other site 247156004147 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 247156004148 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 247156004149 NAD binding site [chemical binding]; other site 247156004150 catalytic Zn binding site [ion binding]; other site 247156004151 substrate binding site [chemical binding]; other site 247156004152 structural Zn binding site [ion binding]; other site 247156004153 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 247156004154 Beta-lactamase; Region: Beta-lactamase; pfam00144 247156004155 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 247156004156 Predicted transcriptional regulators [Transcription]; Region: COG1510 247156004157 HTH domain; Region: HTH_11; cl17392 247156004158 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 247156004159 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 247156004160 Uncharacterized conserved protein [Function unknown]; Region: COG1359 247156004161 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 247156004162 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 247156004163 dimer interface [polypeptide binding]; other site 247156004164 catalytic triad [active] 247156004165 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 247156004166 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 247156004167 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 247156004168 dimer interface [polypeptide binding]; other site 247156004169 TPP-binding site [chemical binding]; other site 247156004170 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 247156004171 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 247156004172 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 247156004173 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 247156004174 acyl carrier protein; Provisional; Region: acpP; PRK00982 247156004175 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 247156004176 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 247156004177 dimer interface [polypeptide binding]; other site 247156004178 active site 247156004179 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 247156004180 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 247156004181 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 247156004182 Predicted transcriptional regulators [Transcription]; Region: COG1733 247156004183 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 247156004184 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 247156004185 putative FMN binding site [chemical binding]; other site 247156004186 Methyltransferase domain; Region: Methyltransf_26; pfam13659 247156004187 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 247156004188 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156004189 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156004190 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 247156004191 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 247156004192 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 247156004193 trimer interface [polypeptide binding]; other site 247156004194 putative metal binding site [ion binding]; other site 247156004195 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 247156004196 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 247156004197 hexamer interface [polypeptide binding]; other site 247156004198 ligand binding site [chemical binding]; other site 247156004199 putative active site [active] 247156004200 NAD(P) binding site [chemical binding]; other site 247156004201 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 247156004202 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 247156004203 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 247156004204 DNA binding residues [nucleotide binding] 247156004205 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 247156004206 Transcriptional regulators [Transcription]; Region: FadR; COG2186 247156004207 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 247156004208 DNA-binding site [nucleotide binding]; DNA binding site 247156004209 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 247156004210 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 247156004211 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 247156004212 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 247156004213 Low molecular weight phosphatase family; Region: LMWPc; cd00115 247156004214 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 247156004215 active site 247156004216 hypothetical protein; Provisional; Region: PRK07908 247156004217 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 247156004218 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156004219 homodimer interface [polypeptide binding]; other site 247156004220 catalytic residue [active] 247156004221 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 247156004222 Uncharacterized conserved protein [Function unknown]; Region: COG0327 247156004223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 247156004224 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 247156004225 EspG family; Region: ESX-1_EspG; pfam14011 247156004226 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 247156004227 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 247156004228 Putative zinc ribbon domain; Region: DUF164; pfam02591 247156004229 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 247156004230 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 247156004231 RNA/DNA hybrid binding site [nucleotide binding]; other site 247156004232 active site 247156004233 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 247156004234 catalytic core [active] 247156004235 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 247156004236 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 247156004237 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 247156004238 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 247156004239 RNB domain; Region: RNB; pfam00773 247156004240 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 247156004241 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 247156004242 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 247156004243 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 247156004244 TAP-like protein; Region: Abhydrolase_4; pfam08386 247156004245 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 247156004246 oligomerization interface [polypeptide binding]; other site 247156004247 active site 247156004248 metal binding site [ion binding]; metal-binding site 247156004249 Helix-turn-helix domain; Region: HTH_18; pfam12833 247156004250 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 247156004251 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 247156004252 putative dimer interface [polypeptide binding]; other site 247156004253 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 247156004254 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 247156004255 CoA-transferase family III; Region: CoA_transf_3; pfam02515 247156004256 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 247156004257 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156004258 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156004259 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 247156004260 TAP-like protein; Region: Abhydrolase_4; pfam08386 247156004261 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 247156004262 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 247156004263 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 247156004264 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 247156004265 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 247156004266 metal binding triad; other site 247156004267 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 247156004268 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 247156004269 metal binding triad; other site 247156004270 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 247156004271 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 247156004272 putative catalytic site [active] 247156004273 putative metal binding site [ion binding]; other site 247156004274 putative phosphate binding site [ion binding]; other site 247156004275 riboflavin synthase subunit beta; Provisional; Region: PRK12419 247156004276 active site 247156004277 homopentamer interface [polypeptide binding]; other site 247156004278 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 247156004279 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 247156004280 hypothetical protein; Provisional; Region: PRK08262 247156004281 M20 Peptidase, carboxypeptidase yscS; Region: M20_yscS; cd05674 247156004282 metal binding site [ion binding]; metal-binding site 247156004283 glutamine synthetase, type I; Region: GlnA; TIGR00653 247156004284 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 247156004285 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 247156004286 RDD family; Region: RDD; pfam06271 247156004287 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 247156004288 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 247156004289 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 247156004290 elongation factor G; Reviewed; Region: PRK12740 247156004291 G1 box; other site 247156004292 putative GEF interaction site [polypeptide binding]; other site 247156004293 GTP/Mg2+ binding site [chemical binding]; other site 247156004294 Switch I region; other site 247156004295 G2 box; other site 247156004296 G3 box; other site 247156004297 Switch II region; other site 247156004298 G4 box; other site 247156004299 G5 box; other site 247156004300 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 247156004301 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 247156004302 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 247156004303 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 247156004304 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 247156004305 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 247156004306 ATP binding site [chemical binding]; other site 247156004307 Mg2+ binding site [ion binding]; other site 247156004308 G-X-G motif; other site 247156004309 Protein of unknown function (DUF742); Region: DUF742; pfam05331 247156004310 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 247156004311 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 247156004312 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156004313 non-specific DNA binding site [nucleotide binding]; other site 247156004314 salt bridge; other site 247156004315 sequence-specific DNA binding site [nucleotide binding]; other site 247156004316 lipoyl synthase; Provisional; Region: PRK05481 247156004317 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 247156004318 FeS/SAM binding site; other site 247156004319 lipoate-protein ligase B; Provisional; Region: PRK14345 247156004320 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 247156004321 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 247156004322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156004323 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 247156004324 NAD(P) binding site [chemical binding]; other site 247156004325 active site 247156004326 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 247156004327 E3 interaction surface; other site 247156004328 lipoyl attachment site [posttranslational modification]; other site 247156004329 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 247156004330 E3 interaction surface; other site 247156004331 lipoyl attachment site [posttranslational modification]; other site 247156004332 e3 binding domain; Region: E3_binding; pfam02817 247156004333 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 247156004334 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 247156004335 multifunctional aminopeptidase A; Provisional; Region: PRK00913 247156004336 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 247156004337 interface (dimer of trimers) [polypeptide binding]; other site 247156004338 Substrate-binding/catalytic site; other site 247156004339 Zn-binding sites [ion binding]; other site 247156004340 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 247156004341 nudix motif; other site 247156004342 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156004343 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 247156004344 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 247156004345 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 247156004346 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 247156004347 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 247156004348 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 247156004349 homodimer interface [polypeptide binding]; other site 247156004350 substrate-cofactor binding pocket; other site 247156004351 catalytic residue [active] 247156004352 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 247156004353 cobalamin synthase; Reviewed; Region: cobS; PRK00235 247156004354 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 247156004355 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 247156004356 putative dimer interface [polypeptide binding]; other site 247156004357 active site pocket [active] 247156004358 putative cataytic base [active] 247156004359 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 247156004360 homotrimer interface [polypeptide binding]; other site 247156004361 Walker A motif; other site 247156004362 GTP binding site [chemical binding]; other site 247156004363 Walker B motif; other site 247156004364 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 247156004365 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 247156004366 conserved cys residue [active] 247156004367 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 247156004368 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 247156004369 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 247156004370 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 247156004371 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 247156004372 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 247156004373 substrate binding site [chemical binding]; other site 247156004374 ATP binding site [chemical binding]; other site 247156004375 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 247156004376 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 247156004377 active site 247156004378 dimer interface [polypeptide binding]; other site 247156004379 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 247156004380 Ligand Binding Site [chemical binding]; other site 247156004381 Molecular Tunnel; other site 247156004382 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 247156004383 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 247156004384 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 247156004385 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 247156004386 FAD binding domain; Region: FAD_binding_4; pfam01565 247156004387 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 247156004388 SpoOM protein; Region: Spo0M; pfam07070 247156004389 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 247156004390 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 247156004391 putative acyl-acceptor binding pocket; other site 247156004392 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 247156004393 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 247156004394 nucleotide binding site [chemical binding]; other site 247156004395 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 247156004396 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 247156004397 P loop; other site 247156004398 Nucleotide binding site [chemical binding]; other site 247156004399 DTAP/Switch II; other site 247156004400 Switch I; other site 247156004401 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 247156004402 putative hydrophobic ligand binding site [chemical binding]; other site 247156004403 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 247156004404 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 247156004405 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 247156004406 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 247156004407 NlpC/P60 family; Region: NLPC_P60; pfam00877 247156004408 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 247156004409 NlpC/P60 family; Region: NLPC_P60; pfam00877 247156004410 hypothetical protein; Validated; Region: PRK07883 247156004411 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 247156004412 active site 247156004413 catalytic site [active] 247156004414 substrate binding site [chemical binding]; other site 247156004415 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 247156004416 GIY-YIG motif/motif A; other site 247156004417 active site 247156004418 catalytic site [active] 247156004419 putative DNA binding site [nucleotide binding]; other site 247156004420 metal binding site [ion binding]; metal-binding site 247156004421 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 247156004422 AsnC family; Region: AsnC_trans_reg; pfam01037 247156004423 anthranilate phosphoribosyltransferase; Region: trpD; TIGR01245 247156004424 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 247156004425 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 247156004426 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 247156004427 Subunit I/III interface [polypeptide binding]; other site 247156004428 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 247156004429 Cytochrome c; Region: Cytochrom_C; pfam00034 247156004430 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 247156004431 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 247156004432 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 247156004433 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 247156004434 iron-sulfur cluster [ion binding]; other site 247156004435 [2Fe-2S] cluster binding site [ion binding]; other site 247156004436 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 247156004437 heme bH binding site [chemical binding]; other site 247156004438 intrachain domain interface; other site 247156004439 heme bL binding site [chemical binding]; other site 247156004440 interchain domain interface [polypeptide binding]; other site 247156004441 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 247156004442 Qo binding site; other site 247156004443 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 247156004444 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 247156004445 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 247156004446 Catalytic domain of Protein Kinases; Region: PKc; cd00180 247156004447 active site 247156004448 ATP binding site [chemical binding]; other site 247156004449 substrate binding site [chemical binding]; other site 247156004450 activation loop (A-loop); other site 247156004451 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 247156004452 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 247156004453 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 247156004454 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 247156004455 catalytic residues [active] 247156004456 substrate binding pocket [chemical binding]; other site 247156004457 aspartate-rich region 2; other site 247156004458 substrate-Mg2+ binding site; other site 247156004459 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 247156004460 phytoene desaturase; Region: crtI_fam; TIGR02734 247156004461 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 247156004462 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 247156004463 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 247156004464 substrate binding pocket [chemical binding]; other site 247156004465 chain length determination region; other site 247156004466 substrate-Mg2+ binding site; other site 247156004467 catalytic residues [active] 247156004468 aspartate-rich region 1; other site 247156004469 active site lid residues [active] 247156004470 aspartate-rich region 2; other site 247156004471 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 247156004472 FAD binding site [chemical binding]; other site 247156004473 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 247156004474 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 247156004475 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 247156004476 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 247156004477 active site 247156004478 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 247156004479 non-prolyl cis peptide bond; other site 247156004480 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 247156004481 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 247156004482 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 247156004483 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 247156004484 Walker A/P-loop; other site 247156004485 ATP binding site [chemical binding]; other site 247156004486 Q-loop/lid; other site 247156004487 ABC transporter signature motif; other site 247156004488 Walker B; other site 247156004489 D-loop; other site 247156004490 H-loop/switch region; other site 247156004491 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 247156004492 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 247156004493 Walker A/P-loop; other site 247156004494 ATP binding site [chemical binding]; other site 247156004495 Q-loop/lid; other site 247156004496 ABC transporter signature motif; other site 247156004497 Walker B; other site 247156004498 D-loop; other site 247156004499 H-loop/switch region; other site 247156004500 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 247156004501 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 247156004502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 247156004503 putative PBP binding loops; other site 247156004504 dimer interface [polypeptide binding]; other site 247156004505 ABC-ATPase subunit interface; other site 247156004506 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 247156004507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 247156004508 dimer interface [polypeptide binding]; other site 247156004509 conserved gate region; other site 247156004510 putative PBP binding loops; other site 247156004511 ABC-ATPase subunit interface; other site 247156004512 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 247156004513 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 247156004514 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 247156004515 Protein of unknown function (DUF422); Region: DUF422; cl00991 247156004516 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 247156004517 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 247156004518 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 247156004519 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 247156004520 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 247156004521 MraZ protein; Region: MraZ; pfam02381 247156004522 MraZ protein; Region: MraZ; pfam02381 247156004523 MraW methylase family; Region: Methyltransf_5; cl17771 247156004524 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 247156004525 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 247156004526 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 247156004527 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 247156004528 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 247156004529 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 247156004530 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 247156004531 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 247156004532 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 247156004533 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 247156004534 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 247156004535 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 247156004536 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 247156004537 Mg++ binding site [ion binding]; other site 247156004538 putative catalytic motif [active] 247156004539 putative substrate binding site [chemical binding]; other site 247156004540 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 247156004541 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 247156004542 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 247156004543 cell division protein FtsW; Region: ftsW; TIGR02614 247156004544 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 247156004545 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 247156004546 active site 247156004547 homodimer interface [polypeptide binding]; other site 247156004548 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 247156004549 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 247156004550 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 247156004551 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 247156004552 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 247156004553 Cell division protein FtsQ; Region: FtsQ; pfam03799 247156004554 cell division protein FtsZ; Validated; Region: PRK09330 247156004555 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 247156004556 nucleotide binding site [chemical binding]; other site 247156004557 SulA interaction site; other site 247156004558 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 247156004559 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 247156004560 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 247156004561 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 247156004562 catalytic residue [active] 247156004563 Protein of unknown function (DUF552); Region: DUF552; cl00775 247156004564 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 247156004565 YGGT family; Region: YGGT; cl00508 247156004566 DivIVA domain; Region: DivI1A_domain; TIGR03544 247156004567 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 247156004568 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 247156004569 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 247156004570 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 247156004571 HIGH motif; other site 247156004572 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 247156004573 active site 247156004574 KMSKS motif; other site 247156004575 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 247156004576 tRNA binding surface [nucleotide binding]; other site 247156004577 anticodon binding site; other site 247156004578 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 247156004579 NlpC/P60 family; Region: NLPC_P60; pfam00877 247156004580 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 247156004581 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 247156004582 active site 247156004583 tetramer interface; other site 247156004584 DNA polymerase IV; Provisional; Region: PRK03348 247156004585 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 247156004586 active site 247156004587 DNA binding site [nucleotide binding] 247156004588 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 247156004589 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 247156004590 Predicted permeases [General function prediction only]; Region: RarD; COG2962 247156004591 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 247156004592 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 247156004593 Soluble P-type ATPase [General function prediction only]; Region: COG4087 247156004594 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 247156004595 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 247156004596 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 247156004597 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 247156004598 active site 247156004599 lipoprotein signal peptidase; Provisional; Region: PRK14764 247156004600 lipoprotein signal peptidase; Provisional; Region: PRK14787 247156004601 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 247156004602 putative dimer interface [polypeptide binding]; other site 247156004603 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 247156004604 acetyl-CoA synthetase; Provisional; Region: PRK00174 247156004605 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 247156004606 active site 247156004607 CoA binding site [chemical binding]; other site 247156004608 acyl-activating enzyme (AAE) consensus motif; other site 247156004609 AMP binding site [chemical binding]; other site 247156004610 acetate binding site [chemical binding]; other site 247156004611 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 247156004612 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 247156004613 Na binding site [ion binding]; other site 247156004614 Protein of unknown function, DUF485; Region: DUF485; pfam04341 247156004615 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 247156004616 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 247156004617 Na binding site [ion binding]; other site 247156004618 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 247156004619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 247156004620 active site 247156004621 phosphorylation site [posttranslational modification] 247156004622 intermolecular recognition site; other site 247156004623 dimerization interface [polypeptide binding]; other site 247156004624 LytTr DNA-binding domain; Region: LytTR; smart00850 247156004625 Histidine kinase; Region: His_kinase; pfam06580 247156004626 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 247156004627 ATP binding site [chemical binding]; other site 247156004628 Mg2+ binding site [ion binding]; other site 247156004629 G-X-G motif; other site 247156004630 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 247156004631 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 247156004632 active site 247156004633 PHP Thumb interface [polypeptide binding]; other site 247156004634 metal binding site [ion binding]; metal-binding site 247156004635 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 247156004636 generic binding surface II; other site 247156004637 generic binding surface I; other site 247156004638 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 247156004639 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156004640 putative substrate translocation pore; other site 247156004641 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156004642 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156004643 Methyltransferase domain; Region: Methyltransf_11; pfam08241 247156004644 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 247156004645 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 247156004646 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 247156004647 catalytic site [active] 247156004648 active site 247156004649 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 247156004650 Beta-lactamase; Region: Beta-lactamase; pfam00144 247156004651 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 247156004652 threonine dehydratase; Validated; Region: PRK08639 247156004653 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 247156004654 tetramer interface [polypeptide binding]; other site 247156004655 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156004656 catalytic residue [active] 247156004657 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 247156004658 Domain of unknown function (DUF385); Region: DUF385; pfam04075 247156004659 AAA ATPase domain; Region: AAA_16; pfam13191 247156004660 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 247156004661 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 247156004662 DNA binding residues [nucleotide binding] 247156004663 dimerization interface [polypeptide binding]; other site 247156004664 SnoaL-like domain; Region: SnoaL_2; pfam12680 247156004665 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 247156004666 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 247156004667 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 247156004668 active site 247156004669 catalytic site [active] 247156004670 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 247156004671 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 247156004672 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 247156004673 active site 247156004674 catalytic site [active] 247156004675 Cupin domain; Region: Cupin_2; pfam07883 247156004676 Transcriptional regulators [Transcription]; Region: MarR; COG1846 247156004677 MarR family; Region: MarR_2; pfam12802 247156004678 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 247156004679 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 247156004680 inhibitor-cofactor binding pocket; inhibition site 247156004681 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156004682 catalytic residue [active] 247156004683 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 247156004684 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 247156004685 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 247156004686 catalytic residue [active] 247156004687 AAA domain; Region: AAA_26; pfam13500 247156004688 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 247156004689 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 247156004690 putative hydrophobic ligand binding site [chemical binding]; other site 247156004691 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 247156004692 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 247156004693 putative ligand binding residues [chemical binding]; other site 247156004694 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 247156004695 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 247156004696 Walker A/P-loop; other site 247156004697 ATP binding site [chemical binding]; other site 247156004698 Q-loop/lid; other site 247156004699 ABC transporter signature motif; other site 247156004700 Walker B; other site 247156004701 D-loop; other site 247156004702 H-loop/switch region; other site 247156004703 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 247156004704 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 247156004705 ABC-ATPase subunit interface; other site 247156004706 dimer interface [polypeptide binding]; other site 247156004707 putative PBP binding regions; other site 247156004708 Thioesterase domain; Region: Thioesterase; pfam00975 247156004709 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 247156004710 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 247156004711 membrane-bound complex binding site; other site 247156004712 hinge residues; other site 247156004713 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 247156004714 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 247156004715 dimer interface [polypeptide binding]; other site 247156004716 conserved gate region; other site 247156004717 putative PBP binding loops; other site 247156004718 ABC-ATPase subunit interface; other site 247156004719 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 247156004720 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156004721 Walker A/P-loop; other site 247156004722 ATP binding site [chemical binding]; other site 247156004723 Q-loop/lid; other site 247156004724 ABC transporter signature motif; other site 247156004725 Walker B; other site 247156004726 D-loop; other site 247156004727 H-loop/switch region; other site 247156004728 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 247156004729 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 247156004730 active site 247156004731 non-prolyl cis peptide bond; other site 247156004732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156004733 Major Facilitator Superfamily; Region: MFS_1; pfam07690 247156004734 putative substrate translocation pore; other site 247156004735 tetracycline repressor protein TetR; Provisional; Region: PRK13756 247156004736 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156004737 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 247156004738 biotin synthase; Validated; Region: PRK06256 247156004739 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 247156004740 FeS/SAM binding site; other site 247156004741 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 247156004742 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 247156004743 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 247156004744 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 247156004745 nudix motif; other site 247156004746 quinolinate synthetase; Provisional; Region: PRK09375 247156004747 L-aspartate oxidase; Provisional; Region: PRK07804 247156004748 L-aspartate oxidase; Provisional; Region: PRK06175 247156004749 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 247156004750 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 247156004751 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 247156004752 dimerization interface [polypeptide binding]; other site 247156004753 active site 247156004754 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 247156004755 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 247156004756 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 247156004757 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 247156004758 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 247156004759 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 247156004760 Catalytic domain of Protein Kinases; Region: PKc; cd00180 247156004761 active site 247156004762 ATP binding site [chemical binding]; other site 247156004763 substrate binding site [chemical binding]; other site 247156004764 activation loop (A-loop); other site 247156004765 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 247156004766 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 247156004767 NAD binding site [chemical binding]; other site 247156004768 dimerization interface [polypeptide binding]; other site 247156004769 product binding site; other site 247156004770 substrate binding site [chemical binding]; other site 247156004771 zinc binding site [ion binding]; other site 247156004772 catalytic residues [active] 247156004773 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 247156004774 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 247156004775 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156004776 homodimer interface [polypeptide binding]; other site 247156004777 catalytic residue [active] 247156004778 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 247156004779 putative active site pocket [active] 247156004780 4-fold oligomerization interface [polypeptide binding]; other site 247156004781 metal binding residues [ion binding]; metal-binding site 247156004782 3-fold/trimer interface [polypeptide binding]; other site 247156004783 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 247156004784 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 247156004785 putative active site [active] 247156004786 oxyanion strand; other site 247156004787 catalytic triad [active] 247156004788 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 247156004789 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 247156004790 catalytic residues [active] 247156004791 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 247156004792 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 247156004793 active site 247156004794 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 247156004795 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 247156004796 substrate binding site [chemical binding]; other site 247156004797 glutamase interaction surface [polypeptide binding]; other site 247156004798 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 247156004799 Transcriptional regulators [Transcription]; Region: MarR; COG1846 247156004800 MarR family; Region: MarR_2; cl17246 247156004801 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 247156004802 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 247156004803 catalytic triad [active] 247156004804 anthranilate synthase component I; Provisional; Region: PRK13571 247156004805 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 247156004806 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 247156004807 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 247156004808 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 247156004809 active site 247156004810 ribulose/triose binding site [chemical binding]; other site 247156004811 phosphate binding site [ion binding]; other site 247156004812 substrate (anthranilate) binding pocket [chemical binding]; other site 247156004813 product (indole) binding pocket [chemical binding]; other site 247156004814 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 247156004815 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 247156004816 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156004817 catalytic residue [active] 247156004818 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 247156004819 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 247156004820 substrate binding site [chemical binding]; other site 247156004821 active site 247156004822 catalytic residues [active] 247156004823 heterodimer interface [polypeptide binding]; other site 247156004824 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 247156004825 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 247156004826 TM2 domain; Region: TM2; pfam05154 247156004827 pyruvate kinase; Provisional; Region: PRK06247 247156004828 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 247156004829 domain interfaces; other site 247156004830 active site 247156004831 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 247156004832 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 247156004833 active site 247156004834 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 247156004835 catalytic triad [active] 247156004836 dimer interface [polypeptide binding]; other site 247156004837 Low molecular weight phosphatase family; Region: LMWPc; cl00105 247156004838 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 247156004839 active site 247156004840 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 247156004841 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 247156004842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 247156004843 active site 247156004844 phosphorylation site [posttranslational modification] 247156004845 intermolecular recognition site; other site 247156004846 dimerization interface [polypeptide binding]; other site 247156004847 ANTAR domain; Region: ANTAR; pfam03861 247156004848 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 247156004849 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 247156004850 dimerization interface [polypeptide binding]; other site 247156004851 ligand binding site [chemical binding]; other site 247156004852 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 247156004853 TM-ABC transporter signature motif; other site 247156004854 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 247156004855 TM-ABC transporter signature motif; other site 247156004856 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 247156004857 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 247156004858 Walker A/P-loop; other site 247156004859 ATP binding site [chemical binding]; other site 247156004860 Q-loop/lid; other site 247156004861 ABC transporter signature motif; other site 247156004862 Walker B; other site 247156004863 D-loop; other site 247156004864 H-loop/switch region; other site 247156004865 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 247156004866 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 247156004867 Walker A/P-loop; other site 247156004868 ATP binding site [chemical binding]; other site 247156004869 Q-loop/lid; other site 247156004870 ABC transporter signature motif; other site 247156004871 Walker B; other site 247156004872 D-loop; other site 247156004873 H-loop/switch region; other site 247156004874 DNA polymerase I; Provisional; Region: PRK05755 247156004875 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 247156004876 active site 247156004877 metal binding site 1 [ion binding]; metal-binding site 247156004878 putative 5' ssDNA interaction site; other site 247156004879 metal binding site 3; metal-binding site 247156004880 metal binding site 2 [ion binding]; metal-binding site 247156004881 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 247156004882 putative DNA binding site [nucleotide binding]; other site 247156004883 putative metal binding site [ion binding]; other site 247156004884 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 247156004885 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 247156004886 active site 247156004887 DNA binding site [nucleotide binding] 247156004888 catalytic site [active] 247156004889 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 247156004890 Amidase; Region: Amidase; cl11426 247156004891 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 247156004892 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 247156004893 catalytic residues [active] 247156004894 tartrate dehydrogenase; Region: TTC; TIGR02089 247156004895 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 247156004896 PRC-barrel domain; Region: PRC; pfam05239 247156004897 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 247156004898 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 247156004899 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 247156004900 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 247156004901 DNA binding residues [nucleotide binding] 247156004902 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 247156004903 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 247156004904 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 247156004905 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 247156004906 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 247156004907 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 247156004908 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 247156004909 DNA binding residues [nucleotide binding] 247156004910 acyl-CoA synthetase; Validated; Region: PRK07788 247156004911 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 247156004912 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 247156004913 acyl-activating enzyme (AAE) consensus motif; other site 247156004914 acyl-activating enzyme (AAE) consensus motif; other site 247156004915 AMP binding site [chemical binding]; other site 247156004916 active site 247156004917 CoA binding site [chemical binding]; other site 247156004918 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 247156004919 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 247156004920 substrate binding pocket [chemical binding]; other site 247156004921 membrane-bound complex binding site; other site 247156004922 hinge residues; other site 247156004923 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 247156004924 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 247156004925 dimer interface [polypeptide binding]; other site 247156004926 conserved gate region; other site 247156004927 putative PBP binding loops; other site 247156004928 ABC-ATPase subunit interface; other site 247156004929 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 247156004930 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 247156004931 Walker A/P-loop; other site 247156004932 ATP binding site [chemical binding]; other site 247156004933 Q-loop/lid; other site 247156004934 ABC transporter signature motif; other site 247156004935 Walker B; other site 247156004936 D-loop; other site 247156004937 H-loop/switch region; other site 247156004938 Transcriptional regulator [Transcription]; Region: LysR; COG0583 247156004939 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 247156004940 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 247156004941 dimerization interface [polypeptide binding]; other site 247156004942 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 247156004943 FAD binding domain; Region: FAD_binding_4; pfam01565 247156004944 Berberine and berberine like; Region: BBE; pfam08031 247156004945 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 247156004946 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 247156004947 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156004948 S-adenosylmethionine binding site [chemical binding]; other site 247156004949 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 247156004950 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 247156004951 RNA binding site [nucleotide binding]; other site 247156004952 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 247156004953 RNA binding site [nucleotide binding]; other site 247156004954 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 247156004955 RNA binding site [nucleotide binding]; other site 247156004956 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 247156004957 RNA binding site [nucleotide binding]; other site 247156004958 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 247156004959 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 247156004960 CoA-binding site [chemical binding]; other site 247156004961 ATP-binding [chemical binding]; other site 247156004962 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 247156004963 CARDB; Region: CARDB; pfam07705 247156004964 Protein of unknown function (DUF402); Region: DUF402; cl00979 247156004965 excinuclease ABC subunit B; Provisional; Region: PRK05298 247156004966 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 247156004967 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 247156004968 nucleotide binding region [chemical binding]; other site 247156004969 ATP-binding site [chemical binding]; other site 247156004970 Ultra-violet resistance protein B; Region: UvrB; pfam12344 247156004971 UvrB/uvrC motif; Region: UVR; pfam02151 247156004972 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 247156004973 putative dimer interface [polypeptide binding]; other site 247156004974 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 247156004975 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 247156004976 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 247156004977 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 247156004978 Ligand Binding Site [chemical binding]; other site 247156004979 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 247156004980 Part of AAA domain; Region: AAA_19; pfam13245 247156004981 Family description; Region: UvrD_C_2; pfam13538 247156004982 PAS fold; Region: PAS; pfam00989 247156004983 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 247156004984 putative active site [active] 247156004985 heme pocket [chemical binding]; other site 247156004986 PAS domain S-box; Region: sensory_box; TIGR00229 247156004987 PAS domain; Region: PAS_8; pfam13188 247156004988 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 247156004989 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 247156004990 metal binding site [ion binding]; metal-binding site 247156004991 active site 247156004992 I-site; other site 247156004993 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 247156004994 active site 247156004995 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 247156004996 30S subunit binding site; other site 247156004997 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 247156004998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 247156004999 active site 247156005000 phosphorylation site [posttranslational modification] 247156005001 intermolecular recognition site; other site 247156005002 dimerization interface [polypeptide binding]; other site 247156005003 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 247156005004 DNA binding residues [nucleotide binding] 247156005005 dimerization interface [polypeptide binding]; other site 247156005006 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 247156005007 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 247156005008 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 247156005009 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 247156005010 DinB superfamily; Region: DinB_2; pfam12867 247156005011 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 247156005012 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 247156005013 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 247156005014 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 247156005015 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 247156005016 23S rRNA binding site [nucleotide binding]; other site 247156005017 L21 binding site [polypeptide binding]; other site 247156005018 L13 binding site [polypeptide binding]; other site 247156005019 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 247156005020 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 247156005021 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 247156005022 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 247156005023 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 247156005024 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 247156005025 dimer interface [polypeptide binding]; other site 247156005026 motif 1; other site 247156005027 active site 247156005028 motif 2; other site 247156005029 motif 3; other site 247156005030 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 247156005031 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 247156005032 putative tRNA-binding site [nucleotide binding]; other site 247156005033 B3/4 domain; Region: B3_4; pfam03483 247156005034 tRNA synthetase B5 domain; Region: B5; smart00874 247156005035 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 247156005036 dimer interface [polypeptide binding]; other site 247156005037 motif 1; other site 247156005038 motif 3; other site 247156005039 motif 2; other site 247156005040 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 247156005041 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 247156005042 Predicted transcriptional regulators [Transcription]; Region: COG1733 247156005043 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 247156005044 short chain dehydrogenase; Provisional; Region: PRK07806 247156005045 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 247156005046 NAD(P) binding site [chemical binding]; other site 247156005047 active site 247156005048 Predicted transcriptional regulators [Transcription]; Region: COG1695 247156005049 Transcriptional regulator PadR-like family; Region: PadR; cl17335 247156005050 Domain of unknown function (DUF427); Region: DUF427; pfam04248 247156005051 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 247156005052 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 247156005053 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 247156005054 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 247156005055 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 247156005056 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 247156005057 catalytic residue [active] 247156005058 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156005059 hypothetical protein; Provisional; Region: PRK06753 247156005060 hypothetical protein; Provisional; Region: PRK07236 247156005061 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 247156005062 Predicted transcriptional regulator [Transcription]; Region: COG2378 247156005063 HTH domain; Region: HTH_11; pfam08279 247156005064 WYL domain; Region: WYL; pfam13280 247156005065 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 247156005066 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 247156005067 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 247156005068 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 247156005069 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 247156005070 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 247156005071 heterotetramer interface [polypeptide binding]; other site 247156005072 active site pocket [active] 247156005073 cleavage site 247156005074 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 247156005075 feedback inhibition sensing region; other site 247156005076 homohexameric interface [polypeptide binding]; other site 247156005077 nucleotide binding site [chemical binding]; other site 247156005078 N-acetyl-L-glutamate binding site [chemical binding]; other site 247156005079 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 247156005080 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 247156005081 inhibitor-cofactor binding pocket; inhibition site 247156005082 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156005083 catalytic residue [active] 247156005084 ornithine carbamoyltransferase; Provisional; Region: PRK00779 247156005085 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 247156005086 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 247156005087 arginine repressor; Provisional; Region: PRK03341 247156005088 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 247156005089 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 247156005090 Phosphotransferase enzyme family; Region: APH; pfam01636 247156005091 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 247156005092 substrate binding site [chemical binding]; other site 247156005093 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 247156005094 active site pocket [active] 247156005095 oxyanion hole [active] 247156005096 catalytic triad [active] 247156005097 active site nucleophile [active] 247156005098 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156005099 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 247156005100 non-specific DNA binding site [nucleotide binding]; other site 247156005101 salt bridge; other site 247156005102 sequence-specific DNA binding site [nucleotide binding]; other site 247156005103 Transcriptional regulators [Transcription]; Region: MarR; COG1846 247156005104 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 247156005105 TIGR03086 family protein; Region: TIGR03086 247156005106 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 247156005107 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 247156005108 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 247156005109 membrane-bound complex binding site; other site 247156005110 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 247156005111 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 247156005112 Walker A/P-loop; other site 247156005113 ATP binding site [chemical binding]; other site 247156005114 Q-loop/lid; other site 247156005115 ABC transporter signature motif; other site 247156005116 Walker B; other site 247156005117 D-loop; other site 247156005118 H-loop/switch region; other site 247156005119 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 247156005120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 247156005121 dimer interface [polypeptide binding]; other site 247156005122 conserved gate region; other site 247156005123 putative PBP binding loops; other site 247156005124 ABC-ATPase subunit interface; other site 247156005125 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 247156005126 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 247156005127 active site 247156005128 non-prolyl cis peptide bond; other site 247156005129 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 247156005130 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 247156005131 active site 247156005132 iron coordination sites [ion binding]; other site 247156005133 substrate binding pocket [chemical binding]; other site 247156005134 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 247156005135 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 247156005136 oligomeric interface; other site 247156005137 putative active site [active] 247156005138 homodimer interface [polypeptide binding]; other site 247156005139 argininosuccinate synthase; Provisional; Region: PRK13820 247156005140 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 247156005141 ANP binding site [chemical binding]; other site 247156005142 Substrate Binding Site II [chemical binding]; other site 247156005143 Substrate Binding Site I [chemical binding]; other site 247156005144 argininosuccinate lyase; Provisional; Region: PRK00855 247156005145 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 247156005146 active sites [active] 247156005147 tetramer interface [polypeptide binding]; other site 247156005148 Transcriptional regulator [Transcription]; Region: LysR; COG0583 247156005149 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 247156005150 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 247156005151 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 247156005152 short chain dehydrogenase; Provisional; Region: PRK07825 247156005153 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156005154 NAD(P) binding site [chemical binding]; other site 247156005155 active site 247156005156 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 247156005157 SnoaL-like domain; Region: SnoaL_3; pfam13474 247156005158 SnoaL-like domain; Region: SnoaL_3; pfam13474 247156005159 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 247156005160 MarR family; Region: MarR_2; pfam12802 247156005161 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 247156005162 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 247156005163 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 247156005164 active site 247156005165 metal binding site [ion binding]; metal-binding site 247156005166 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 247156005167 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 247156005168 Beta-lactamase; Region: Beta-lactamase; pfam00144 247156005169 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 247156005170 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 247156005171 active site 247156005172 metal binding site [ion binding]; metal-binding site 247156005173 nudix motif; other site 247156005174 acyl-CoA synthetase; Validated; Region: PRK07868 247156005175 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 247156005176 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 247156005177 active site 247156005178 CoA binding site [chemical binding]; other site 247156005179 AMP binding site [chemical binding]; other site 247156005180 Methyltransferase domain; Region: Methyltransf_23; pfam13489 247156005181 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156005182 S-adenosylmethionine binding site [chemical binding]; other site 247156005183 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 247156005184 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 247156005185 inhibitor-cofactor binding pocket; inhibition site 247156005186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156005187 catalytic residue [active] 247156005188 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 247156005189 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 247156005190 Ligand binding site; other site 247156005191 Putative Catalytic site; other site 247156005192 DXD motif; other site 247156005193 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 247156005194 GtrA-like protein; Region: GtrA; pfam04138 247156005195 Predicted membrane protein [Function unknown]; Region: COG2246 247156005196 Uncharacterized conserved protein [Function unknown]; Region: COG2835 247156005197 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156005198 ABC-2 type transporter; Region: ABC2_membrane; cl17235 247156005199 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 247156005200 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 247156005201 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 247156005202 Walker A/P-loop; other site 247156005203 ATP binding site [chemical binding]; other site 247156005204 Q-loop/lid; other site 247156005205 ABC transporter signature motif; other site 247156005206 Walker B; other site 247156005207 D-loop; other site 247156005208 H-loop/switch region; other site 247156005209 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 247156005210 active site 247156005211 DNA binding site [nucleotide binding] 247156005212 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 247156005213 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 247156005214 active site 247156005215 HIGH motif; other site 247156005216 dimer interface [polypeptide binding]; other site 247156005217 KMSKS motif; other site 247156005218 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 247156005219 RNA binding surface [nucleotide binding]; other site 247156005220 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 247156005221 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 247156005222 active site 247156005223 motif I; other site 247156005224 motif II; other site 247156005225 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 247156005226 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 247156005227 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 247156005228 RNA binding surface [nucleotide binding]; other site 247156005229 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156005230 S-adenosylmethionine binding site [chemical binding]; other site 247156005231 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 247156005232 ATP-NAD kinase; Region: NAD_kinase; pfam01513 247156005233 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 247156005234 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 247156005235 Walker A/P-loop; other site 247156005236 ATP binding site [chemical binding]; other site 247156005237 Q-loop/lid; other site 247156005238 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 247156005239 ABC transporter signature motif; other site 247156005240 Walker B; other site 247156005241 D-loop; other site 247156005242 H-loop/switch region; other site 247156005243 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 247156005244 putative hydrophobic ligand binding site [chemical binding]; other site 247156005245 protein interface [polypeptide binding]; other site 247156005246 gate; other site 247156005247 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 247156005248 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 247156005249 NAD binding site [chemical binding]; other site 247156005250 catalytic Zn binding site [ion binding]; other site 247156005251 structural Zn binding site [ion binding]; other site 247156005252 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 247156005253 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 247156005254 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 247156005255 Thiamine pyrophosphokinase; Region: TPK; cl08415 247156005256 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 247156005257 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 247156005258 CTP synthetase; Validated; Region: pyrG; PRK05380 247156005259 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 247156005260 Catalytic site [active] 247156005261 active site 247156005262 UTP binding site [chemical binding]; other site 247156005263 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 247156005264 active site 247156005265 putative oxyanion hole; other site 247156005266 catalytic triad [active] 247156005267 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 247156005268 dimer interface [polypeptide binding]; other site 247156005269 active site 247156005270 ADP-ribose binding site [chemical binding]; other site 247156005271 nudix motif; other site 247156005272 metal binding site [ion binding]; metal-binding site 247156005273 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 247156005274 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 247156005275 active site 247156005276 Int/Topo IB signature motif; other site 247156005277 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 247156005278 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 247156005279 P-loop; other site 247156005280 Magnesium ion binding site [ion binding]; other site 247156005281 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 247156005282 Magnesium ion binding site [ion binding]; other site 247156005283 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 247156005284 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 247156005285 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 247156005286 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 247156005287 RNA binding surface [nucleotide binding]; other site 247156005288 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 247156005289 active site 247156005290 cytidylate kinase; Provisional; Region: cmk; PRK00023 247156005291 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 247156005292 CMP-binding site; other site 247156005293 The sites determining sugar specificity; other site 247156005294 GTP-binding protein Der; Reviewed; Region: PRK03003 247156005295 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 247156005296 G1 box; other site 247156005297 GTP/Mg2+ binding site [chemical binding]; other site 247156005298 Switch I region; other site 247156005299 G2 box; other site 247156005300 Switch II region; other site 247156005301 G3 box; other site 247156005302 G4 box; other site 247156005303 G5 box; other site 247156005304 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 247156005305 G1 box; other site 247156005306 GTP/Mg2+ binding site [chemical binding]; other site 247156005307 Switch I region; other site 247156005308 G2 box; other site 247156005309 G3 box; other site 247156005310 Switch II region; other site 247156005311 G4 box; other site 247156005312 G5 box; other site 247156005313 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 247156005314 active site 247156005315 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 247156005316 active site 2 [active] 247156005317 active site 1 [active] 247156005318 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 247156005319 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 247156005320 acyl-activating enzyme (AAE) consensus motif; other site 247156005321 AMP binding site [chemical binding]; other site 247156005322 active site 247156005323 CoA binding site [chemical binding]; other site 247156005324 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 247156005325 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156005326 NAD(P) binding site [chemical binding]; other site 247156005327 active site 247156005328 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 247156005329 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 247156005330 active site 247156005331 Zn binding site [ion binding]; other site 247156005332 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 247156005333 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 247156005334 putative metal binding site [ion binding]; other site 247156005335 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 247156005336 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 247156005337 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 247156005338 DNA binding residues [nucleotide binding] 247156005339 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 247156005340 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 247156005341 Walker A/P-loop; other site 247156005342 ATP binding site [chemical binding]; other site 247156005343 Q-loop/lid; other site 247156005344 ABC transporter signature motif; other site 247156005345 Walker B; other site 247156005346 D-loop; other site 247156005347 H-loop/switch region; other site 247156005348 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 247156005349 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 247156005350 Mechanosensitive ion channel; Region: MS_channel; pfam00924 247156005351 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 247156005352 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 247156005353 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 247156005354 Ligand Binding Site [chemical binding]; other site 247156005355 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 247156005356 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 247156005357 DNA-binding site [nucleotide binding]; DNA binding site 247156005358 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 247156005359 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156005360 homodimer interface [polypeptide binding]; other site 247156005361 catalytic residue [active] 247156005362 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 247156005363 CoenzymeA binding site [chemical binding]; other site 247156005364 subunit interaction site [polypeptide binding]; other site 247156005365 PHB binding site; other site 247156005366 PAS fold; Region: PAS_3; pfam08447 247156005367 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 247156005368 heme pocket [chemical binding]; other site 247156005369 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 247156005370 Peptidase S8 family domain, uncharacterized subfamily 12; Region: Peptidases_S8_12; cd07480 247156005371 active site 247156005372 catalytic triad [active] 247156005373 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 247156005374 Zinc-dependent metalloprotease; MMP_like sub-family 3. A group of bacterial and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_3; cd04327 247156005375 active site 247156005376 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 247156005377 The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6, and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348 247156005378 putative active site [active] 247156005379 putative metal binding site [ion binding]; other site 247156005380 Flavoprotein; Region: Flavoprotein; pfam02441 247156005381 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156005382 non-specific DNA binding site [nucleotide binding]; other site 247156005383 salt bridge; other site 247156005384 sequence-specific DNA binding site [nucleotide binding]; other site 247156005385 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 247156005386 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 247156005387 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 247156005388 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156005389 non-specific DNA binding site [nucleotide binding]; other site 247156005390 salt bridge; other site 247156005391 sequence-specific DNA binding site [nucleotide binding]; other site 247156005392 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 247156005393 classical (c) SDRs; Region: SDR_c; cd05233 247156005394 NAD(P) binding site [chemical binding]; other site 247156005395 active site 247156005396 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 247156005397 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 247156005398 active site 247156005399 Zn binding site [ion binding]; other site 247156005400 GAF domain; Region: GAF_2; pfam13185 247156005401 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 247156005402 DNA binding residues [nucleotide binding] 247156005403 Transcriptional regulator PadR-like family; Region: PadR; cl17335 247156005404 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 247156005405 putative dimer interface [polypeptide binding]; other site 247156005406 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 247156005407 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156005408 metabolite-proton symporter; Region: 2A0106; TIGR00883 247156005409 putative substrate translocation pore; other site 247156005410 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08269 247156005411 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 247156005412 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 247156005413 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 247156005414 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 247156005415 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 247156005416 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 247156005417 AsnC family; Region: AsnC_trans_reg; pfam01037 247156005418 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 247156005419 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 247156005420 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 247156005421 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 247156005422 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 247156005423 homodimer interface [polypeptide binding]; other site 247156005424 active site 247156005425 TDP-binding site; other site 247156005426 acceptor substrate-binding pocket; other site 247156005427 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 247156005428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156005429 putative substrate translocation pore; other site 247156005430 Major Facilitator Superfamily; Region: MFS_1; pfam07690 247156005431 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 247156005432 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 247156005433 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722 247156005434 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 247156005435 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156005436 S-adenosylmethionine binding site [chemical binding]; other site 247156005437 T5orf172 domain; Region: T5orf172; pfam10544 247156005438 Homeodomain-like domain; Region: HTH_23; cl17451 247156005439 Integrase core domain; Region: rve; pfam00665 247156005440 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 247156005441 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 247156005442 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 247156005443 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 247156005444 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 247156005445 thiocyanate hydrolase, gamma subunit; Region: thiocyan_alph; TIGR03887 247156005446 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 247156005447 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 247156005448 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 247156005449 hypothetical protein; Provisional; Region: PRK07588 247156005450 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 247156005451 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 247156005452 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 247156005453 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156005454 NAD(P) binding site [chemical binding]; other site 247156005455 active site 247156005456 metabolite-proton symporter; Region: 2A0106; TIGR00883 247156005457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156005458 putative substrate translocation pore; other site 247156005459 Transcriptional regulators [Transcription]; Region: GntR; COG1802 247156005460 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 247156005461 DNA-binding site [nucleotide binding]; DNA binding site 247156005462 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 247156005463 Predicted amidohydrolase [General function prediction only]; Region: COG0388 247156005464 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 247156005465 putative active site [active] 247156005466 catalytic triad [active] 247156005467 putative dimer interface [polypeptide binding]; other site 247156005468 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 247156005469 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 247156005470 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156005471 active site 247156005472 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 247156005473 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 247156005474 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 247156005475 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156005476 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156005477 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156005478 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156005479 active site 247156005480 short chain dehydrogenase; Provisional; Region: PRK07791 247156005481 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156005482 NAD(P) binding site [chemical binding]; other site 247156005483 active site 247156005484 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 247156005485 active site 247156005486 catalytic site [active] 247156005487 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 247156005488 dimer interaction site [polypeptide binding]; other site 247156005489 substrate-binding tunnel; other site 247156005490 active site 247156005491 catalytic site [active] 247156005492 substrate binding site [chemical binding]; other site 247156005493 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 247156005494 hydrophobic ligand binding site; other site 247156005495 lipid-transfer protein; Provisional; Region: PRK08256 247156005496 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 247156005497 active site 247156005498 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 247156005499 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 247156005500 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 247156005501 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 247156005502 NAD binding site [chemical binding]; other site 247156005503 catalytic Zn binding site [ion binding]; other site 247156005504 substrate binding site [chemical binding]; other site 247156005505 structural Zn binding site [ion binding]; other site 247156005506 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 247156005507 TrkA-N domain; Region: TrkA_N; pfam02254 247156005508 TrkA-C domain; Region: TrkA_C; pfam02080 247156005509 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 247156005510 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 247156005511 allantoate amidohydrolase; Reviewed; Region: PRK09290 247156005512 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 247156005513 active site 247156005514 metal binding site [ion binding]; metal-binding site 247156005515 dimer interface [polypeptide binding]; other site 247156005516 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 247156005517 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 247156005518 active site 247156005519 FMN binding site [chemical binding]; other site 247156005520 substrate binding site [chemical binding]; other site 247156005521 3Fe-4S cluster binding site [ion binding]; other site 247156005522 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 247156005523 domain_subunit interface; other site 247156005524 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 247156005525 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 247156005526 putative active site [active] 247156005527 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 247156005528 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 247156005529 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 247156005530 hydroxyglutarate oxidase; Provisional; Region: PRK11728 247156005531 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 247156005532 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 247156005533 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 247156005534 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 247156005535 FMN-binding pocket [chemical binding]; other site 247156005536 flavin binding motif; other site 247156005537 phosphate binding motif [ion binding]; other site 247156005538 beta-alpha-beta structure motif; other site 247156005539 NAD binding pocket [chemical binding]; other site 247156005540 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 247156005541 catalytic loop [active] 247156005542 iron binding site [ion binding]; other site 247156005543 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 247156005544 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 247156005545 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 247156005546 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156005547 non-specific DNA binding site [nucleotide binding]; other site 247156005548 salt bridge; other site 247156005549 sequence-specific DNA binding site [nucleotide binding]; other site 247156005550 Cupin domain; Region: Cupin_2; pfam07883 247156005551 Uncharacterized conserved protein [Function unknown]; Region: COG2128 247156005552 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 247156005553 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 247156005554 DNA-binding site [nucleotide binding]; DNA binding site 247156005555 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 247156005556 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 247156005557 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156005558 homodimer interface [polypeptide binding]; other site 247156005559 catalytic residue [active] 247156005560 MarR family; Region: MarR_2; pfam12802 247156005561 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 247156005562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 247156005563 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 247156005564 putative active site [active] 247156005565 putative metal binding site [ion binding]; other site 247156005566 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 247156005567 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 247156005568 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156005569 salt bridge; other site 247156005570 non-specific DNA binding site [nucleotide binding]; other site 247156005571 sequence-specific DNA binding site [nucleotide binding]; other site 247156005572 YceI-like domain; Region: YceI; pfam04264 247156005573 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 247156005574 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 247156005575 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 247156005576 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 247156005577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 247156005578 dimer interface [polypeptide binding]; other site 247156005579 conserved gate region; other site 247156005580 putative PBP binding loops; other site 247156005581 ABC-ATPase subunit interface; other site 247156005582 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 247156005583 NMT1-like family; Region: NMT1_2; pfam13379 247156005584 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 247156005585 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156005586 Walker A/P-loop; other site 247156005587 ATP binding site [chemical binding]; other site 247156005588 Q-loop/lid; other site 247156005589 ABC transporter signature motif; other site 247156005590 Walker B; other site 247156005591 D-loop; other site 247156005592 H-loop/switch region; other site 247156005593 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156005594 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 247156005595 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156005596 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156005597 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 247156005598 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 247156005599 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 247156005600 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 247156005601 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 247156005602 Cytochrome P450; Region: p450; cl12078 247156005603 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 247156005604 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 247156005605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156005606 S-adenosylmethionine binding site [chemical binding]; other site 247156005607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 247156005608 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 247156005609 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 247156005610 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 247156005611 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156005612 Walker A/P-loop; other site 247156005613 ATP binding site [chemical binding]; other site 247156005614 Q-loop/lid; other site 247156005615 ABC transporter signature motif; other site 247156005616 Walker B; other site 247156005617 D-loop; other site 247156005618 H-loop/switch region; other site 247156005619 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 247156005620 Walker A/P-loop; other site 247156005621 ATP binding site [chemical binding]; other site 247156005622 Q-loop/lid; other site 247156005623 ABC transporter signature motif; other site 247156005624 Walker B; other site 247156005625 D-loop; other site 247156005626 H-loop/switch region; other site 247156005627 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 247156005628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156005629 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 247156005630 putative substrate translocation pore; other site 247156005631 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156005632 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156005633 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 247156005634 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156005635 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 247156005636 Walker A/P-loop; other site 247156005637 ATP binding site [chemical binding]; other site 247156005638 Q-loop/lid; other site 247156005639 ABC transporter signature motif; other site 247156005640 Walker B; other site 247156005641 D-loop; other site 247156005642 H-loop/switch region; other site 247156005643 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 247156005644 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 247156005645 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 247156005646 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 247156005647 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 247156005648 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 247156005649 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 247156005650 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 247156005651 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156005652 Walker A/P-loop; other site 247156005653 ATP binding site [chemical binding]; other site 247156005654 Q-loop/lid; other site 247156005655 ABC transporter signature motif; other site 247156005656 Walker B; other site 247156005657 D-loop; other site 247156005658 H-loop/switch region; other site 247156005659 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 247156005660 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 247156005661 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156005662 Walker A/P-loop; other site 247156005663 ATP binding site [chemical binding]; other site 247156005664 Q-loop/lid; other site 247156005665 ABC transporter signature motif; other site 247156005666 Walker B; other site 247156005667 D-loop; other site 247156005668 H-loop/switch region; other site 247156005669 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 247156005670 classical (c) SDRs; Region: SDR_c; cd05233 247156005671 NAD(P) binding site [chemical binding]; other site 247156005672 active site 247156005673 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 247156005674 Transcriptional regulator [Transcription]; Region: LysR; COG0583 247156005675 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 247156005676 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 247156005677 dimerization interface [polypeptide binding]; other site 247156005678 substrate binding pocket [chemical binding]; other site 247156005679 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 247156005680 CoenzymeA binding site [chemical binding]; other site 247156005681 subunit interaction site [polypeptide binding]; other site 247156005682 PHB binding site; other site 247156005683 conserved hypothetical protein; Region: TIGR02118 247156005684 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 247156005685 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 247156005686 substrate binding site [chemical binding]; other site 247156005687 dimer interface [polypeptide binding]; other site 247156005688 NADP binding site [chemical binding]; other site 247156005689 catalytic residues [active] 247156005690 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 247156005691 active site 2 [active] 247156005692 active site 1 [active] 247156005693 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156005694 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156005695 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 247156005696 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 247156005697 dimer interface [polypeptide binding]; other site 247156005698 active site 247156005699 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 247156005700 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 247156005701 substrate binding site [chemical binding]; other site 247156005702 oxyanion hole (OAH) forming residues; other site 247156005703 trimer interface [polypeptide binding]; other site 247156005704 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 247156005705 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 247156005706 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 247156005707 enoyl-CoA hydratase; Provisional; Region: PRK06072 247156005708 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 247156005709 substrate binding site [chemical binding]; other site 247156005710 oxyanion hole (OAH) forming residues; other site 247156005711 trimer interface [polypeptide binding]; other site 247156005712 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 247156005713 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 247156005714 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 247156005715 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 247156005716 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 247156005717 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 247156005718 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 247156005719 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 247156005720 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 247156005721 FAD binding pocket [chemical binding]; other site 247156005722 FAD binding motif [chemical binding]; other site 247156005723 phosphate binding motif [ion binding]; other site 247156005724 beta-alpha-beta structure motif; other site 247156005725 NAD(p) ribose binding residues [chemical binding]; other site 247156005726 NAD binding pocket [chemical binding]; other site 247156005727 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 247156005728 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 247156005729 catalytic loop [active] 247156005730 iron binding site [ion binding]; other site 247156005731 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 247156005732 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 247156005733 active site 247156005734 AMP binding site [chemical binding]; other site 247156005735 homodimer interface [polypeptide binding]; other site 247156005736 acyl-activating enzyme (AAE) consensus motif; other site 247156005737 CoA binding site [chemical binding]; other site 247156005738 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 247156005739 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 247156005740 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156005741 Walker A/P-loop; other site 247156005742 ATP binding site [chemical binding]; other site 247156005743 Q-loop/lid; other site 247156005744 ABC transporter signature motif; other site 247156005745 Walker B; other site 247156005746 D-loop; other site 247156005747 H-loop/switch region; other site 247156005748 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 247156005749 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 247156005750 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 247156005751 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 247156005752 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156005753 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156005754 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 247156005755 Cytochrome P450; Region: p450; cl12078 247156005756 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156005757 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156005758 active site 247156005759 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156005760 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156005761 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 247156005762 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 247156005763 Coenzyme A binding pocket [chemical binding]; other site 247156005764 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 247156005765 dimerization interface [polypeptide binding]; other site 247156005766 putative DNA binding site [nucleotide binding]; other site 247156005767 putative Zn2+ binding site [ion binding]; other site 247156005768 H+ Antiporter protein; Region: 2A0121; TIGR00900 247156005769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156005770 putative substrate translocation pore; other site 247156005771 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 247156005772 Bacterial transcriptional regulator; Region: IclR; pfam01614 247156005773 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 247156005774 ethanolamine permease; Region: 2A0305; TIGR00908 247156005775 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 247156005776 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 247156005777 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 247156005778 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 247156005779 active site 247156005780 metal binding site [ion binding]; metal-binding site 247156005781 homotetramer interface [polypeptide binding]; other site 247156005782 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 247156005783 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 247156005784 Zn binding site [ion binding]; other site 247156005785 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 247156005786 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 247156005787 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 247156005788 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 247156005789 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 247156005790 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 247156005791 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 247156005792 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 247156005793 acyl-activating enzyme (AAE) consensus motif; other site 247156005794 active site 247156005795 AMP binding site [chemical binding]; other site 247156005796 substrate binding site [chemical binding]; other site 247156005797 hypothetical protein; Provisional; Region: PRK07236 247156005798 FAD binding domain; Region: FAD_binding_3; pfam01494 247156005799 hypothetical protein; Provisional; Region: PRK07236 247156005800 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156005801 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156005802 short chain dehydrogenase; Provisional; Region: PRK07825 247156005803 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156005804 NAD(P) binding site [chemical binding]; other site 247156005805 active site 247156005806 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 247156005807 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 247156005808 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 247156005809 Protein of unknown function (DUF429); Region: DUF429; cl12046 247156005810 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156005811 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156005812 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 247156005813 substrate binding pocket [chemical binding]; other site 247156005814 chain length determination region; other site 247156005815 substrate-Mg2+ binding site; other site 247156005816 catalytic residues [active] 247156005817 aspartate-rich region 1; other site 247156005818 active site lid residues [active] 247156005819 aspartate-rich region 2; other site 247156005820 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 247156005821 Fatty acid desaturase; Region: FA_desaturase; pfam00487 247156005822 putative di-iron ligands [ion binding]; other site 247156005823 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 247156005824 mevalonate kinase; Region: mevalon_kin; TIGR00549 247156005825 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 247156005826 diphosphomevalonate decarboxylase; Region: PLN02407 247156005827 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 247156005828 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 247156005829 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 247156005830 homotetramer interface [polypeptide binding]; other site 247156005831 FMN binding site [chemical binding]; other site 247156005832 homodimer contacts [polypeptide binding]; other site 247156005833 putative active site [active] 247156005834 putative substrate binding site [chemical binding]; other site 247156005835 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 247156005836 homodimer interface [polypeptide binding]; other site 247156005837 substrate binding pocket [chemical binding]; other site 247156005838 catalytic residues [active] 247156005839 NADH/NADPH cofactor binding site [chemical binding]; other site 247156005840 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 247156005841 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 247156005842 dimer interface [polypeptide binding]; other site 247156005843 active site 247156005844 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 247156005845 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 247156005846 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 247156005847 Beta-lactamase; Region: Beta-lactamase; pfam00144 247156005848 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 247156005849 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 247156005850 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 247156005851 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 247156005852 DNA binding residues [nucleotide binding] 247156005853 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 247156005854 Coenzyme A binding pocket [chemical binding]; other site 247156005855 Amidase; Region: Amidase; cl11426 247156005856 allophanate hydrolase; Region: allophanate_hyd; TIGR02713 247156005857 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 247156005858 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 247156005859 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 247156005860 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 247156005861 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 247156005862 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 247156005863 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 247156005864 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156005865 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156005866 NDMA-dependent methanol dehydrogenase; Region: NDMA_methanol; TIGR04266 247156005867 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 247156005868 active site 247156005869 NAD binding site [chemical binding]; other site 247156005870 metal binding site [ion binding]; metal-binding site 247156005871 MoxR-like ATPases [General function prediction only]; Region: COG0714 247156005872 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 247156005873 Walker B motif; other site 247156005874 arginine finger; other site 247156005875 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 247156005876 Methyltransferase domain; Region: Methyltransf_11; pfam08241 247156005877 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 247156005878 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 247156005879 catalytic loop [active] 247156005880 iron binding site [ion binding]; other site 247156005881 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 247156005882 FAD binding pocket [chemical binding]; other site 247156005883 FAD binding motif [chemical binding]; other site 247156005884 phosphate binding motif [ion binding]; other site 247156005885 beta-alpha-beta structure motif; other site 247156005886 NAD binding pocket [chemical binding]; other site 247156005887 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 247156005888 Cytochrome P450; Region: p450; cl12078 247156005889 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 247156005890 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 247156005891 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 247156005892 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 247156005893 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 247156005894 Probable Catalytic site; other site 247156005895 metal-binding site 247156005896 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 247156005897 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 247156005898 phosphate binding site [ion binding]; other site 247156005899 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 247156005900 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 247156005901 FeS/SAM binding site; other site 247156005902 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 247156005903 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 247156005904 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 247156005905 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 247156005906 active site 247156005907 NAD binding site [chemical binding]; other site 247156005908 metal binding site [ion binding]; metal-binding site 247156005909 GAF domain; Region: GAF_3; pfam13492 247156005910 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 247156005911 Histidine kinase; Region: HisKA_3; pfam07730 247156005912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 247156005913 ATP binding site [chemical binding]; other site 247156005914 Mg2+ binding site [ion binding]; other site 247156005915 G-X-G motif; other site 247156005916 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 247156005917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 247156005918 active site 247156005919 phosphorylation site [posttranslational modification] 247156005920 intermolecular recognition site; other site 247156005921 dimerization interface [polypeptide binding]; other site 247156005922 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 247156005923 DNA binding residues [nucleotide binding] 247156005924 dimerization interface [polypeptide binding]; other site 247156005925 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156005926 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 247156005927 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 247156005928 active site 247156005929 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156005930 sequence-specific DNA binding site [nucleotide binding]; other site 247156005931 salt bridge; other site 247156005932 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156005933 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156005934 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 247156005935 classical (c) SDRs; Region: SDR_c; cd05233 247156005936 NAD(P) binding site [chemical binding]; other site 247156005937 active site 247156005938 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 247156005939 classical (c) SDRs; Region: SDR_c; cd05233 247156005940 NAD(P) binding site [chemical binding]; other site 247156005941 active site 247156005942 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 247156005943 3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837 247156005944 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 247156005945 Predicted transcriptional regulators [Transcription]; Region: COG1695 247156005946 Transcriptional regulator PadR-like family; Region: PadR; cl17335 247156005947 Transcriptional regulator [Transcription]; Region: IclR; COG1414 247156005948 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 247156005949 Bacterial transcriptional regulator; Region: IclR; pfam01614 247156005950 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156005951 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156005952 active site 247156005953 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 247156005954 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 247156005955 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 247156005956 hydrophobic ligand binding site; other site 247156005957 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 247156005958 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 247156005959 active site 2 [active] 247156005960 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156005961 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 247156005962 NAD(P) binding site [chemical binding]; other site 247156005963 active site 247156005964 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 247156005965 Prostaglandin dehydrogenases; Region: PGDH; cd05288 247156005966 NAD(P) binding site [chemical binding]; other site 247156005967 substrate binding site [chemical binding]; other site 247156005968 dimer interface [polypeptide binding]; other site 247156005969 tricarballylate dehydrogenase; Validated; Region: PRK08274 247156005970 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 247156005971 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 247156005972 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 247156005973 phosphate binding site [ion binding]; other site 247156005974 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 247156005975 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 247156005976 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156005977 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 247156005978 NAD(P) binding site [chemical binding]; other site 247156005979 active site 247156005980 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 247156005981 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156005982 Walker A/P-loop; other site 247156005983 ATP binding site [chemical binding]; other site 247156005984 Q-loop/lid; other site 247156005985 ABC transporter signature motif; other site 247156005986 Walker B; other site 247156005987 D-loop; other site 247156005988 H-loop/switch region; other site 247156005989 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 247156005990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 247156005991 dimer interface [polypeptide binding]; other site 247156005992 conserved gate region; other site 247156005993 putative PBP binding loops; other site 247156005994 ABC-ATPase subunit interface; other site 247156005995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 247156005996 dimer interface [polypeptide binding]; other site 247156005997 conserved gate region; other site 247156005998 putative PBP binding loops; other site 247156005999 ABC-ATPase subunit interface; other site 247156006000 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156006001 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 247156006002 NAD(P) binding site [chemical binding]; other site 247156006003 active site 247156006004 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 247156006005 EthD domain; Region: EthD; cl17553 247156006006 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 247156006007 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156006008 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 247156006009 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 247156006010 acyl-activating enzyme (AAE) consensus motif; other site 247156006011 AMP binding site [chemical binding]; other site 247156006012 active site 247156006013 CoA binding site [chemical binding]; other site 247156006014 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 247156006015 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 247156006016 NAD binding site [chemical binding]; other site 247156006017 substrate binding site [chemical binding]; other site 247156006018 catalytic Zn binding site [ion binding]; other site 247156006019 structural Zn binding site [ion binding]; other site 247156006020 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156006021 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 247156006022 NAD(P) binding site [chemical binding]; other site 247156006023 active site 247156006024 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 247156006025 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156006026 NAD(P) binding site [chemical binding]; other site 247156006027 active site 247156006028 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156006029 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156006030 active site 247156006031 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 247156006032 Phosphotransferase enzyme family; Region: APH; pfam01636 247156006033 putative active site [active] 247156006034 putative substrate binding site [chemical binding]; other site 247156006035 ATP binding site [chemical binding]; other site 247156006036 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156006037 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156006038 active site 247156006039 lipid-transfer protein; Provisional; Region: PRK08256 247156006040 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 247156006041 active site 247156006042 DUF35 OB-fold domain; Region: DUF35; pfam01796 247156006043 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 247156006044 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 247156006045 substrate binding site [chemical binding]; other site 247156006046 oxyanion hole (OAH) forming residues; other site 247156006047 trimer interface [polypeptide binding]; other site 247156006048 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 247156006049 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 247156006050 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 247156006051 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156006052 active site 247156006053 SnoaL-like domain; Region: SnoaL_2; pfam12680 247156006054 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 247156006055 DNA binding residues [nucleotide binding] 247156006056 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 247156006057 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 247156006058 DNA binding residues [nucleotide binding] 247156006059 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156006060 S-adenosylmethionine binding site [chemical binding]; other site 247156006061 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 247156006062 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 247156006063 active site 247156006064 Zn binding site [ion binding]; other site 247156006065 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 247156006066 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 247156006067 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 247156006068 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156006069 non-specific DNA binding site [nucleotide binding]; other site 247156006070 salt bridge; other site 247156006071 sequence-specific DNA binding site [nucleotide binding]; other site 247156006072 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 247156006073 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 247156006074 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 247156006075 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156006076 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 247156006077 Walker A/P-loop; other site 247156006078 ATP binding site [chemical binding]; other site 247156006079 Q-loop/lid; other site 247156006080 ABC transporter signature motif; other site 247156006081 Walker B; other site 247156006082 D-loop; other site 247156006083 H-loop/switch region; other site 247156006084 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156006085 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156006086 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 247156006087 Putative sensor; Region: Sensor; pfam13796 247156006088 Histidine kinase; Region: HisKA_3; pfam07730 247156006089 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 247156006090 ATP binding site [chemical binding]; other site 247156006091 Mg2+ binding site [ion binding]; other site 247156006092 G-X-G motif; other site 247156006093 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 247156006094 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 247156006095 active site 247156006096 phosphorylation site [posttranslational modification] 247156006097 intermolecular recognition site; other site 247156006098 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 247156006099 DNA binding residues [nucleotide binding] 247156006100 dimerization interface [polypeptide binding]; other site 247156006101 short chain dehydrogenase; Provisional; Region: PRK06123 247156006102 classical (c) SDRs; Region: SDR_c; cd05233 247156006103 NAD(P) binding site [chemical binding]; other site 247156006104 active site 247156006105 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 247156006106 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 247156006107 Cytochrome P450; Region: p450; cl12078 247156006108 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156006109 short chain dehydrogenase; Validated; Region: PRK08264 247156006110 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156006111 NAD(P) binding site [chemical binding]; other site 247156006112 active site 247156006113 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 247156006114 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 247156006115 putative hydrophobic ligand binding site [chemical binding]; other site 247156006116 CLM binding site; other site 247156006117 L1 loop; other site 247156006118 DNA binding site [nucleotide binding] 247156006119 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 247156006120 dimerization interface [polypeptide binding]; other site 247156006121 putative DNA binding site [nucleotide binding]; other site 247156006122 putative Zn2+ binding site [ion binding]; other site 247156006123 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 247156006124 Uncharacterized conserved protein [Function unknown]; Region: COG2128 247156006125 Cupin; Region: Cupin_6; pfam12852 247156006126 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 247156006127 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 247156006128 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 247156006129 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 247156006130 NADH(P)-binding; Region: NAD_binding_10; pfam13460 247156006131 NAD binding site [chemical binding]; other site 247156006132 substrate binding site [chemical binding]; other site 247156006133 putative active site [active] 247156006134 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 247156006135 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 247156006136 conserved cys residue [active] 247156006137 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 247156006138 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 247156006139 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 247156006140 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 247156006141 DNA binding residues [nucleotide binding] 247156006142 putative dimer interface [polypeptide binding]; other site 247156006143 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 247156006144 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 247156006145 active site 247156006146 catalytic tetrad [active] 247156006147 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156006148 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 247156006149 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 247156006150 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 247156006151 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 247156006152 Lipase (class 2); Region: Lipase_2; pfam01674 247156006153 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 247156006154 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 247156006155 Lsr2; Region: Lsr2; pfam11774 247156006156 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 247156006157 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 247156006158 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 247156006159 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 247156006160 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 247156006161 AAA domain; Region: AAA_23; pfam13476 247156006162 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 247156006163 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 247156006164 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 247156006165 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 247156006166 ABC-ATPase subunit interface; other site 247156006167 dimer interface [polypeptide binding]; other site 247156006168 putative PBP binding regions; other site 247156006169 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 247156006170 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 247156006171 intersubunit interface [polypeptide binding]; other site 247156006172 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 247156006173 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 247156006174 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 247156006175 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 247156006176 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 247156006177 DNA binding residues [nucleotide binding] 247156006178 Asp23 family; Region: Asp23; pfam03780 247156006179 Hemerythrin-like domain; Region: Hr-like; cd12108 247156006180 Fe binding site [ion binding]; other site 247156006181 oxidoreductase; Provisional; Region: PRK12743 247156006182 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156006183 NAD(P) binding site [chemical binding]; other site 247156006184 active site 247156006185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156006186 Major Facilitator Superfamily; Region: MFS_1; pfam07690 247156006187 putative substrate translocation pore; other site 247156006188 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 247156006189 hydrophobic ligand binding site; other site 247156006190 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 247156006191 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 247156006192 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 247156006193 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 247156006194 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 247156006195 Uncharacterized conserved protein [Function unknown]; Region: COG2353 247156006196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 247156006197 ATP binding site [chemical binding]; other site 247156006198 Mg2+ binding site [ion binding]; other site 247156006199 G-X-G motif; other site 247156006200 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 247156006201 Protein of unknown function (DUF742); Region: DUF742; pfam05331 247156006202 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 247156006203 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 247156006204 G1 box; other site 247156006205 GTP/Mg2+ binding site [chemical binding]; other site 247156006206 G2 box; other site 247156006207 Switch I region; other site 247156006208 G3 box; other site 247156006209 Switch II region; other site 247156006210 G4 box; other site 247156006211 Proline dehydrogenase; Region: Pro_dh; cl03282 247156006212 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 247156006213 ligand binding site [chemical binding]; other site 247156006214 active site 247156006215 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 247156006216 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 247156006217 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156006218 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 247156006219 DNA-binding interface [nucleotide binding]; DNA binding site 247156006220 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 247156006221 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 247156006222 NAD(P) binding site [chemical binding]; other site 247156006223 homotetramer interface [polypeptide binding]; other site 247156006224 homodimer interface [polypeptide binding]; other site 247156006225 active site 247156006226 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 247156006227 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 247156006228 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 247156006229 Catalytic domain of Protein Kinases; Region: PKc; cd00180 247156006230 active site 247156006231 ATP binding site [chemical binding]; other site 247156006232 substrate binding site [chemical binding]; other site 247156006233 activation loop (A-loop); other site 247156006234 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 247156006235 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 247156006236 putative oxidoreductase; Provisional; Region: PRK11579 247156006237 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 247156006238 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 247156006239 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 247156006240 conserved cys residue [active] 247156006241 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 247156006242 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 247156006243 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 247156006244 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 247156006245 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 247156006246 FAD binding pocket [chemical binding]; other site 247156006247 FAD binding motif [chemical binding]; other site 247156006248 phosphate binding motif [ion binding]; other site 247156006249 NAD binding pocket [chemical binding]; other site 247156006250 Phytosulfokine precursor protein (PSK); Region: PSK; pfam06404 247156006251 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 247156006252 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 247156006253 Putative esterase; Region: Esterase; pfam00756 247156006254 S-formylglutathione hydrolase; Region: PLN02442 247156006255 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 247156006256 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 247156006257 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 247156006258 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 247156006259 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 247156006260 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 247156006261 Probable Catalytic site; other site 247156006262 metal-binding site 247156006263 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 247156006264 dimer interface [polypeptide binding]; other site 247156006265 FMN binding site [chemical binding]; other site 247156006266 NADPH bind site [chemical binding]; other site 247156006267 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 247156006268 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 247156006269 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 247156006270 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156006271 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 247156006272 putative substrate translocation pore; other site 247156006273 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 247156006274 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 247156006275 putative active site [active] 247156006276 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 247156006277 substrate binding site [chemical binding]; other site 247156006278 ATP binding site [chemical binding]; other site 247156006279 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 247156006280 dimer interface [polypeptide binding]; other site 247156006281 active site 247156006282 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 247156006283 active site 247156006284 motif I; other site 247156006285 motif II; other site 247156006286 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 247156006287 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 247156006288 putative active site [active] 247156006289 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 247156006290 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 247156006291 classical (c) SDRs; Region: SDR_c; cd05233 247156006292 NAD(P) binding site [chemical binding]; other site 247156006293 active site 247156006294 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 247156006295 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 247156006296 putative ADP-binding pocket [chemical binding]; other site 247156006297 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 247156006298 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 247156006299 putative active site [active] 247156006300 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 247156006301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156006302 Major Facilitator Superfamily; Region: MFS_1; pfam07690 247156006303 Secretory lipase; Region: LIP; pfam03583 247156006304 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156006305 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156006306 short chain dehydrogenase; Provisional; Region: PRK08263 247156006307 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 247156006308 NADP binding site [chemical binding]; other site 247156006309 active site 247156006310 steroid binding site; other site 247156006311 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 247156006312 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 247156006313 active site 247156006314 acyl-activating enzyme (AAE) consensus motif; other site 247156006315 putative CoA binding site [chemical binding]; other site 247156006316 AMP binding site [chemical binding]; other site 247156006317 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 247156006318 active site 2 [active] 247156006319 active site 1 [active] 247156006320 metabolite-proton symporter; Region: 2A0106; TIGR00883 247156006321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156006322 putative substrate translocation pore; other site 247156006323 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156006324 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156006325 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 247156006326 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 247156006327 active site 247156006328 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 247156006329 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 247156006330 substrate binding site [chemical binding]; other site 247156006331 ATP binding site [chemical binding]; other site 247156006332 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 247156006333 active site 247156006334 nucleotide binding site [chemical binding]; other site 247156006335 HIGH motif; other site 247156006336 KMSKS motif; other site 247156006337 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 247156006338 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 247156006339 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 247156006340 putative NAD(P) binding site [chemical binding]; other site 247156006341 active site 247156006342 putative substrate binding site [chemical binding]; other site 247156006343 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156006344 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 247156006345 NAD(P) binding site [chemical binding]; other site 247156006346 active site 247156006347 Lsr2; Region: Lsr2; pfam11774 247156006348 acyl-CoA synthetase; Provisional; Region: PRK13388 247156006349 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 247156006350 acyl-activating enzyme (AAE) consensus motif; other site 247156006351 AMP binding site [chemical binding]; other site 247156006352 active site 247156006353 CoA binding site [chemical binding]; other site 247156006354 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 247156006355 classical (c) SDRs; Region: SDR_c; cd05233 247156006356 NAD(P) binding site [chemical binding]; other site 247156006357 active site 247156006358 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 247156006359 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 247156006360 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 247156006361 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 247156006362 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156006363 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156006364 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 247156006365 hydrophobic ligand binding site; other site 247156006366 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 247156006367 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 247156006368 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 247156006369 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 247156006370 NAD binding site [chemical binding]; other site 247156006371 homodimer interface [polypeptide binding]; other site 247156006372 homotetramer interface [polypeptide binding]; other site 247156006373 active site 247156006374 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 247156006375 Catalytic domain of Protein Kinases; Region: PKc; cd00180 247156006376 active site 247156006377 ATP binding site [chemical binding]; other site 247156006378 substrate binding site [chemical binding]; other site 247156006379 activation loop (A-loop); other site 247156006380 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 247156006381 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 247156006382 Catalytic domain of Protein Kinases; Region: PKc; cd00180 247156006383 active site 247156006384 ATP binding site [chemical binding]; other site 247156006385 substrate binding site [chemical binding]; other site 247156006386 activation loop (A-loop); other site 247156006387 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 247156006388 hypothetical protein; Provisional; Region: PRK07338 247156006389 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 247156006390 metal binding site [ion binding]; metal-binding site 247156006391 dimer interface [polypeptide binding]; other site 247156006392 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156006393 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156006394 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 247156006395 Cytochrome P450; Region: p450; cl12078 247156006396 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 247156006397 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 247156006398 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 247156006399 metal binding site [ion binding]; metal-binding site 247156006400 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 247156006401 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 247156006402 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 247156006403 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 247156006404 dimer interface [polypeptide binding]; other site 247156006405 putative PBP binding regions; other site 247156006406 ABC-ATPase subunit interface; other site 247156006407 LGFP repeat; Region: LGFP; pfam08310 247156006408 LGFP repeat; Region: LGFP; pfam08310 247156006409 LGFP repeat; Region: LGFP; pfam08310 247156006410 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 247156006411 L-aspartate oxidase; Provisional; Region: PRK06175 247156006412 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 247156006413 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 247156006414 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 247156006415 Walker A/P-loop; other site 247156006416 ATP binding site [chemical binding]; other site 247156006417 Q-loop/lid; other site 247156006418 ABC transporter signature motif; other site 247156006419 Walker B; other site 247156006420 D-loop; other site 247156006421 H-loop/switch region; other site 247156006422 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 247156006423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 247156006424 dimer interface [polypeptide binding]; other site 247156006425 conserved gate region; other site 247156006426 putative PBP binding loops; other site 247156006427 ABC-ATPase subunit interface; other site 247156006428 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 247156006429 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 247156006430 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 247156006431 DNA-binding site [nucleotide binding]; DNA binding site 247156006432 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 247156006433 UTRA domain; Region: UTRA; pfam07702 247156006434 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 247156006435 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 247156006436 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156006437 active site 247156006438 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 247156006439 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 247156006440 dimerization interface [polypeptide binding]; other site 247156006441 putative DNA binding site [nucleotide binding]; other site 247156006442 putative Zn2+ binding site [ion binding]; other site 247156006443 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 247156006444 arsenical-resistance protein; Region: acr3; TIGR00832 247156006445 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 247156006446 Low molecular weight phosphatase family; Region: LMWPc; cd00115 247156006447 active site 247156006448 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 247156006449 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 247156006450 putative metal binding site [ion binding]; other site 247156006451 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 247156006452 dimerization interface [polypeptide binding]; other site 247156006453 putative DNA binding site [nucleotide binding]; other site 247156006454 putative Zn2+ binding site [ion binding]; other site 247156006455 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 247156006456 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 247156006457 G1 box; other site 247156006458 putative GEF interaction site [polypeptide binding]; other site 247156006459 GTP/Mg2+ binding site [chemical binding]; other site 247156006460 Switch I region; other site 247156006461 G2 box; other site 247156006462 CysD dimerization site [polypeptide binding]; other site 247156006463 G3 box; other site 247156006464 Switch II region; other site 247156006465 G4 box; other site 247156006466 G5 box; other site 247156006467 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 247156006468 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 247156006469 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 247156006470 ligand-binding site [chemical binding]; other site 247156006471 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 247156006472 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 247156006473 Active Sites [active] 247156006474 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 247156006475 short chain dehydrogenase; Provisional; Region: PRK07890 247156006476 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156006477 NAD(P) binding site [chemical binding]; other site 247156006478 active site 247156006479 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 247156006480 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 247156006481 CoenzymeA binding site [chemical binding]; other site 247156006482 subunit interaction site [polypeptide binding]; other site 247156006483 PHB binding site; other site 247156006484 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 247156006485 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 247156006486 motif I; other site 247156006487 active site 247156006488 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 247156006489 motif II; other site 247156006490 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 247156006491 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156006492 Walker A/P-loop; other site 247156006493 ATP binding site [chemical binding]; other site 247156006494 Q-loop/lid; other site 247156006495 ABC transporter signature motif; other site 247156006496 Walker B; other site 247156006497 D-loop; other site 247156006498 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 247156006499 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 247156006500 DNA-binding site [nucleotide binding]; DNA binding site 247156006501 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 247156006502 Transcriptional regulators [Transcription]; Region: FadR; COG2186 247156006503 Protein of unknown function (DUF664); Region: DUF664; pfam04978 247156006504 Transcriptional regulator [Transcription]; Region: IclR; COG1414 247156006505 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 247156006506 short chain dehydrogenase; Provisional; Region: PRK07814 247156006507 classical (c) SDRs; Region: SDR_c; cd05233 247156006508 NAD(P) binding site [chemical binding]; other site 247156006509 active site 247156006510 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 247156006511 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 247156006512 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 247156006513 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 247156006514 Transcriptional regulator [Transcription]; Region: IclR; COG1414 247156006515 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 247156006516 Bacterial transcriptional regulator; Region: IclR; pfam01614 247156006517 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 247156006518 heme binding pocket [chemical binding]; other site 247156006519 heme ligand [chemical binding]; other site 247156006520 Uncharacterized conserved protein [Function unknown]; Region: COG2966 247156006521 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 247156006522 Uncharacterized conserved protein [Function unknown]; Region: COG3610 247156006523 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 247156006524 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 247156006525 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 247156006526 Walker A/P-loop; other site 247156006527 ATP binding site [chemical binding]; other site 247156006528 Q-loop/lid; other site 247156006529 ABC transporter signature motif; other site 247156006530 Walker B; other site 247156006531 D-loop; other site 247156006532 H-loop/switch region; other site 247156006533 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 247156006534 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156006535 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156006536 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156006537 active site 247156006538 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 247156006539 Nuclease-related domain; Region: NERD; pfam08378 247156006540 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 247156006541 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 247156006542 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 247156006543 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 247156006544 4Fe-4S binding domain; Region: Fer4; cl02805 247156006545 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 247156006546 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 247156006547 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 247156006548 lipoyl attachment site [posttranslational modification]; other site 247156006549 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 247156006550 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 247156006551 phosphopeptide binding site; other site 247156006552 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 247156006553 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 247156006554 DNA binding residues [nucleotide binding] 247156006555 Bifunctional nuclease; Region: DNase-RNase; pfam02577 247156006556 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 247156006557 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 247156006558 DNA binding residues [nucleotide binding] 247156006559 putative dimer interface [polypeptide binding]; other site 247156006560 glycine dehydrogenase; Provisional; Region: PRK05367 247156006561 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 247156006562 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156006563 tetramer interface [polypeptide binding]; other site 247156006564 catalytic residue [active] 247156006565 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 247156006566 tetramer interface [polypeptide binding]; other site 247156006567 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156006568 catalytic residue [active] 247156006569 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156006570 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156006571 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 247156006572 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156006573 Walker A/P-loop; other site 247156006574 ATP binding site [chemical binding]; other site 247156006575 Q-loop/lid; other site 247156006576 ABC transporter signature motif; other site 247156006577 Walker B; other site 247156006578 D-loop; other site 247156006579 H-loop/switch region; other site 247156006580 ABC transporter; Region: ABC_tran_2; pfam12848 247156006581 Helicase; Region: Herpes_Helicase; pfam02689 247156006582 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156006583 Walker A/P-loop; other site 247156006584 ATP binding site [chemical binding]; other site 247156006585 Q-loop/lid; other site 247156006586 ABC transporter signature motif; other site 247156006587 Walker B; other site 247156006588 D-loop; other site 247156006589 H-loop/switch region; other site 247156006590 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 247156006591 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 247156006592 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 247156006593 metal ion-dependent adhesion site (MIDAS); other site 247156006594 Transcription factor WhiB; Region: Whib; pfam02467 247156006595 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 247156006596 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 247156006597 active site 247156006598 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156006599 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156006600 active site 247156006601 Predicted transcriptional regulators [Transcription]; Region: COG1733 247156006602 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 247156006603 SCP-2 sterol transfer family; Region: SCP2; pfam02036 247156006604 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156006605 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156006606 active site 247156006607 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156006608 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156006609 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 247156006610 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 247156006611 NAD(P) binding site [chemical binding]; other site 247156006612 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 247156006613 classical (c) SDRs; Region: SDR_c; cd05233 247156006614 NAD(P) binding site [chemical binding]; other site 247156006615 active site 247156006616 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 247156006617 active site 247156006618 Domain of unknown function (DUF305); Region: DUF305; pfam03713 247156006619 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 247156006620 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 247156006621 Predicted esterase [General function prediction only]; Region: COG0627 247156006622 S-formylglutathione hydrolase; Region: PLN02442 247156006623 Domain of unknown function DUF21; Region: DUF21; pfam01595 247156006624 FOG: CBS domain [General function prediction only]; Region: COG0517 247156006625 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 247156006626 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 247156006627 Domain of unknown function DUF21; Region: DUF21; pfam01595 247156006628 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 247156006629 Transporter associated domain; Region: CorC_HlyC; smart01091 247156006630 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 247156006631 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 247156006632 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 247156006633 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 247156006634 active site 247156006635 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 247156006636 DEAD-like helicases superfamily; Region: DEXDc; smart00487 247156006637 ATP binding site [chemical binding]; other site 247156006638 Mg++ binding site [ion binding]; other site 247156006639 motif III; other site 247156006640 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 247156006641 nucleotide binding region [chemical binding]; other site 247156006642 ATP-binding site [chemical binding]; other site 247156006643 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 247156006644 Predicted transcriptional regulator [Transcription]; Region: COG3682 247156006645 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 247156006646 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 247156006647 Walker A/P-loop; other site 247156006648 ATP binding site [chemical binding]; other site 247156006649 Q-loop/lid; other site 247156006650 ABC transporter signature motif; other site 247156006651 Walker B; other site 247156006652 D-loop; other site 247156006653 H-loop/switch region; other site 247156006654 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 247156006655 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 247156006656 ABC-ATPase subunit interface; other site 247156006657 dimer interface [polypeptide binding]; other site 247156006658 putative PBP binding regions; other site 247156006659 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 247156006660 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 247156006661 ABC-ATPase subunit interface; other site 247156006662 dimer interface [polypeptide binding]; other site 247156006663 putative PBP binding regions; other site 247156006664 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 247156006665 CoenzymeA binding site [chemical binding]; other site 247156006666 subunit interaction site [polypeptide binding]; other site 247156006667 PHB binding site; other site 247156006668 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 247156006669 alpha-gamma subunit interface [polypeptide binding]; other site 247156006670 beta-gamma subunit interface [polypeptide binding]; other site 247156006671 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 247156006672 gamma-beta subunit interface [polypeptide binding]; other site 247156006673 alpha-beta subunit interface [polypeptide binding]; other site 247156006674 urease subunit alpha; Reviewed; Region: ureC; PRK13206 247156006675 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 247156006676 subunit interactions [polypeptide binding]; other site 247156006677 active site 247156006678 flap region; other site 247156006679 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 247156006680 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 247156006681 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 247156006682 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 247156006683 active site 247156006684 catalytic triad [active] 247156006685 oxyanion hole [active] 247156006686 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 247156006687 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156006688 S-adenosylmethionine binding site [chemical binding]; other site 247156006689 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156006690 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156006691 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 247156006692 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156006693 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 247156006694 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 247156006695 Walker A/P-loop; other site 247156006696 ATP binding site [chemical binding]; other site 247156006697 Q-loop/lid; other site 247156006698 ABC transporter signature motif; other site 247156006699 Walker B; other site 247156006700 D-loop; other site 247156006701 H-loop/switch region; other site 247156006702 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 247156006703 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156006704 S-adenosylmethionine binding site [chemical binding]; other site 247156006705 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 247156006706 UreF; Region: UreF; pfam01730 247156006707 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 247156006708 TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex; Region: TAF6; cl17395 247156006709 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 247156006710 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 247156006711 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 247156006712 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 247156006713 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 247156006714 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 247156006715 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 247156006716 Family description; Region: UvrD_C_2; pfam13538 247156006717 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 247156006718 AAA domain; Region: AAA_30; pfam13604 247156006719 Family description; Region: UvrD_C_2; pfam13538 247156006720 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 247156006721 active site 247156006722 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 247156006723 active site 247156006724 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 247156006725 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156006726 putative substrate translocation pore; other site 247156006727 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 247156006728 CoA-transferase family III; Region: CoA_transf_3; pfam02515 247156006729 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 247156006730 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 247156006731 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156006732 NAD(P) binding site [chemical binding]; other site 247156006733 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156006734 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 247156006735 active site 247156006736 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 247156006737 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156006738 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156006739 active site 247156006740 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156006741 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156006742 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 247156006743 nucleotide binding site [chemical binding]; other site 247156006744 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 247156006745 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 247156006746 active site 247156006747 DNA binding site [nucleotide binding] 247156006748 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 247156006749 DNA binding site [nucleotide binding] 247156006750 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 247156006751 DNA-binding site [nucleotide binding]; DNA binding site 247156006752 RNA-binding motif; other site 247156006753 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156006754 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156006755 active site 247156006756 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156006757 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 247156006758 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 247156006759 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 247156006760 catalytic residue [active] 247156006761 Rhodanese-like domain; Region: Rhodanese; pfam00581 247156006762 active site residue [active] 247156006763 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842 247156006764 dimer interface [polypeptide binding]; other site 247156006765 active site 247156006766 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 247156006767 catalytic residues [active] 247156006768 substrate binding site [chemical binding]; other site 247156006769 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 247156006770 metal-binding site [ion binding] 247156006771 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 247156006772 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 247156006773 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 247156006774 catalytic residue [active] 247156006775 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 247156006776 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 247156006777 FOG: CBS domain [General function prediction only]; Region: COG0517 247156006778 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 247156006779 MMPL family; Region: MMPL; pfam03176 247156006780 Methyltransferase domain; Region: Methyltransf_24; pfam13578 247156006781 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 247156006782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156006783 S-adenosylmethionine binding site [chemical binding]; other site 247156006784 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 247156006785 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 247156006786 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 247156006787 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 247156006788 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 247156006789 Cytochrome P450; Region: p450; cl12078 247156006790 short chain dehydrogenase; Provisional; Region: PRK07775 247156006791 classical (c) SDRs; Region: SDR_c; cd05233 247156006792 NAD(P) binding site [chemical binding]; other site 247156006793 active site 247156006794 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 247156006795 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 247156006796 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 247156006797 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 247156006798 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 247156006799 Cytochrome P450; Region: p450; cl12078 247156006800 Ferredoxin [Energy production and conversion]; Region: COG1146 247156006801 4Fe-4S binding domain; Region: Fer4; pfam00037 247156006802 ferredoxin-NADP+ reductase; Region: PLN02852 247156006803 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 247156006804 Cytochrome P450; Region: p450; cl12078 247156006805 mce related protein; Region: MCE; pfam02470 247156006806 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 247156006807 classical (c) SDRs; Region: SDR_c; cd05233 247156006808 NAD(P) binding site [chemical binding]; other site 247156006809 active site 247156006810 Phosphotransferase enzyme family; Region: APH; pfam01636 247156006811 Ecdysteroid kinase; Region: EcKinase; cl17738 247156006812 Uncharacterized conserved protein [Function unknown]; Region: COG3349 247156006813 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 247156006814 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 247156006815 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156006816 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156006817 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156006818 GXWXG protein; Region: GXWXG; pfam14231 247156006819 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 247156006820 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 247156006821 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 247156006822 catalytic Zn binding site [ion binding]; other site 247156006823 NAD binding site [chemical binding]; other site 247156006824 structural Zn binding site [ion binding]; other site 247156006825 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 247156006826 Domain of unknown function (DUF397); Region: DUF397; pfam04149 247156006827 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156006828 non-specific DNA binding site [nucleotide binding]; other site 247156006829 salt bridge; other site 247156006830 sequence-specific DNA binding site [nucleotide binding]; other site 247156006831 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156006832 NADH(P)-binding; Region: NAD_binding_10; pfam13460 247156006833 NAD(P) binding site [chemical binding]; other site 247156006834 active site 247156006835 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 247156006836 Helix-turn-helix domain; Region: HTH_31; pfam13560 247156006837 acyl-CoA synthetase; Validated; Region: PRK07788 247156006838 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 247156006839 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 247156006840 acyl-activating enzyme (AAE) consensus motif; other site 247156006841 acyl-activating enzyme (AAE) consensus motif; other site 247156006842 AMP binding site [chemical binding]; other site 247156006843 active site 247156006844 CoA binding site [chemical binding]; other site 247156006845 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 247156006846 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 247156006847 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 247156006848 Acid Phosphatase; Region: Acid_PPase; cl17256 247156006849 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 247156006850 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 247156006851 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 247156006852 choline dehydrogenase; Validated; Region: PRK02106 247156006853 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 247156006854 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 247156006855 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 247156006856 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 247156006857 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 247156006858 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 247156006859 DNA binding residues [nucleotide binding] 247156006860 dimer interface [polypeptide binding]; other site 247156006861 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 247156006862 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156006863 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156006864 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 247156006865 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 247156006866 beta-galactosidase; Region: BGL; TIGR03356 247156006867 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 247156006868 haloalkane dehalogenase; Provisional; Region: PRK03204 247156006869 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 247156006870 active site 247156006871 DNA binding site [nucleotide binding] 247156006872 Int/Topo IB signature motif; other site 247156006873 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 247156006874 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 247156006875 HTH domain; Region: HTH_11; pfam08279 247156006876 WYL domain; Region: WYL; pfam13280 247156006877 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 247156006878 homotrimer interaction site [polypeptide binding]; other site 247156006879 putative active site [active] 247156006880 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 247156006881 dimerization interface [polypeptide binding]; other site 247156006882 putative DNA binding site [nucleotide binding]; other site 247156006883 Transcriptional regulators [Transcription]; Region: MarR; COG1846 247156006884 putative Zn2+ binding site [ion binding]; other site 247156006885 Cation efflux family; Region: Cation_efflux; cl00316 247156006886 Short repeat of unknown function (DUF308); Region: DUF308; pfam03729 247156006887 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 247156006888 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 247156006889 Radical SAM superfamily; Region: Radical_SAM; pfam04055 247156006890 FeS/SAM binding site; other site 247156006891 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156006892 WHG domain; Region: WHG; pfam13305 247156006893 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 247156006894 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 247156006895 EamA-like transporter family; Region: EamA; pfam00892 247156006896 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 247156006897 Domain of unknown function (DUF336); Region: DUF336; cl01249 247156006898 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 247156006899 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 247156006900 active site 247156006901 Predicted transcriptional regulators [Transcription]; Region: COG1695 247156006902 Transcriptional regulator PadR-like family; Region: PadR; cl17335 247156006903 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 247156006904 active site 247156006905 catalytic residues [active] 247156006906 metal binding site [ion binding]; metal-binding site 247156006907 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 247156006908 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 247156006909 Coenzyme A binding pocket [chemical binding]; other site 247156006910 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 247156006911 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 247156006912 catalytic site [active] 247156006913 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 247156006914 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 247156006915 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 247156006916 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 247156006917 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 247156006918 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 247156006919 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 247156006920 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 247156006921 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 247156006922 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 247156006923 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 247156006924 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 247156006925 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 247156006926 4Fe-4S binding domain; Region: Fer4; pfam00037 247156006927 4Fe-4S binding domain; Region: Fer4; pfam00037 247156006928 NADH dehydrogenase subunit G; Validated; Region: PRK07860 247156006929 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 247156006930 catalytic loop [active] 247156006931 iron binding site [ion binding]; other site 247156006932 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 247156006933 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 247156006934 molybdopterin cofactor binding site; other site 247156006935 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 247156006936 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 247156006937 SLBB domain; Region: SLBB; pfam10531 247156006938 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 247156006939 NADH dehydrogenase subunit E; Validated; Region: PRK07539 247156006940 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 247156006941 putative dimer interface [polypeptide binding]; other site 247156006942 [2Fe-2S] cluster binding site [ion binding]; other site 247156006943 NADH dehydrogenase subunit D; Validated; Region: PRK06075 247156006944 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 247156006945 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 247156006946 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 247156006947 NADH dehydrogenase subunit B; Validated; Region: PRK06411 247156006948 NADH dehydrogenase subunit A; Validated; Region: PRK07928 247156006949 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 247156006950 active site 247156006951 phosphorylation site [posttranslational modification] 247156006952 intermolecular recognition site; other site 247156006953 dimerization interface [polypeptide binding]; other site 247156006954 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 247156006955 DNA polymerase IV; Validated; Region: PRK03858 247156006956 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 247156006957 active site 247156006958 DNA binding site [nucleotide binding] 247156006959 Transcriptional regulator [Transcription]; Region: LysR; COG0583 247156006960 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 247156006961 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 247156006962 putative dimerization interface [polypeptide binding]; other site 247156006963 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 247156006964 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 247156006965 dimer interface [polypeptide binding]; other site 247156006966 active site 247156006967 catalytic residue [active] 247156006968 transcriptional regulator BetI; Validated; Region: PRK00767 247156006969 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 247156006970 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 247156006971 nudix motif; other site 247156006972 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 247156006973 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 247156006974 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 247156006975 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 247156006976 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 247156006977 G1 box; other site 247156006978 GTP/Mg2+ binding site [chemical binding]; other site 247156006979 G2 box; other site 247156006980 Switch I region; other site 247156006981 G3 box; other site 247156006982 Switch II region; other site 247156006983 G4 box; other site 247156006984 G5 box; other site 247156006985 Protein of unknown function (DUF742); Region: DUF742; pfam05331 247156006986 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 247156006987 Nitrate and nitrite sensing; Region: NIT; pfam08376 247156006988 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 247156006989 ATP binding site [chemical binding]; other site 247156006990 Mg2+ binding site [ion binding]; other site 247156006991 G-X-G motif; other site 247156006992 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 247156006993 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 247156006994 NAD(P) binding site [chemical binding]; other site 247156006995 catalytic residues [active] 247156006996 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 247156006997 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156006998 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156006999 WHG domain; Region: WHG; pfam13305 247156007000 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156007001 cinnamyl-alcohol dehydrogenase family protein; Region: PLN02662 247156007002 NAD(P) binding site [chemical binding]; other site 247156007003 active site 247156007004 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 247156007005 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 247156007006 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 247156007007 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 247156007008 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 247156007009 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 247156007010 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 247156007011 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 247156007012 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 247156007013 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 247156007014 ATP-grasp domain; Region: ATP-grasp_4; cl17255 247156007015 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 247156007016 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 247156007017 lipoyl-biotinyl attachment site [posttranslational modification]; other site 247156007018 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 247156007019 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 247156007020 short chain dehydrogenase; Provisional; Region: PRK07832 247156007021 classical (c) SDRs; Region: SDR_c; cd05233 247156007022 NAD(P) binding site [chemical binding]; other site 247156007023 active site 247156007024 active site 247156007025 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 247156007026 FAD dependent oxidoreductase; Region: DAO; pfam01266 247156007027 hydroxyglutarate oxidase; Provisional; Region: PRK11728 247156007028 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 247156007029 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 247156007030 [2Fe-2S] cluster binding site [ion binding]; other site 247156007031 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 247156007032 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 247156007033 active site 247156007034 metal binding site [ion binding]; metal-binding site 247156007035 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 247156007036 ChaB; Region: ChaB; pfam06150 247156007037 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 247156007038 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 247156007039 putative ADP-binding pocket [chemical binding]; other site 247156007040 hydroperoxidase II; Provisional; Region: katE; PRK11249 247156007041 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 247156007042 heme binding pocket [chemical binding]; other site 247156007043 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 247156007044 domain interactions; other site 247156007045 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 247156007046 anti sigma factor interaction site; other site 247156007047 regulatory phosphorylation site [posttranslational modification]; other site 247156007048 PAS fold; Region: PAS_3; pfam08447 247156007049 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 247156007050 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 247156007051 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 247156007052 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 247156007053 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 247156007054 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 247156007055 DNA binding residues [nucleotide binding] 247156007056 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 247156007057 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 247156007058 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 247156007059 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 247156007060 Soluble P-type ATPase [General function prediction only]; Region: COG4087 247156007061 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 247156007062 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 247156007063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 247156007064 active site 247156007065 phosphorylation site [posttranslational modification] 247156007066 intermolecular recognition site; other site 247156007067 dimerization interface [polypeptide binding]; other site 247156007068 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 247156007069 DNA binding site [nucleotide binding] 247156007070 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 247156007071 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 247156007072 Coenzyme A binding pocket [chemical binding]; other site 247156007073 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 247156007074 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 247156007075 inhibitor-cofactor binding pocket; inhibition site 247156007076 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156007077 catalytic residue [active] 247156007078 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 247156007079 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 247156007080 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 247156007081 Catalytic domain of Protein Kinases; Region: PKc; cd00180 247156007082 active site 247156007083 ATP binding site [chemical binding]; other site 247156007084 substrate binding site [chemical binding]; other site 247156007085 activation loop (A-loop); other site 247156007086 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 247156007087 Ribosomal RNA adenine dimethylases; Region: rADc; smart00650 247156007088 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 247156007089 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 247156007090 Uncharacterized conserved protein [Function unknown]; Region: COG2128 247156007091 portal vertex protein; Provisional; Region: 20; PHA02531 247156007092 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 247156007093 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 247156007094 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 247156007095 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 247156007096 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 247156007097 Fe-S cluster binding site [ion binding]; other site 247156007098 active site 247156007099 carboxylate-amine ligase; Provisional; Region: PRK13517 247156007100 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 247156007101 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 247156007102 SnoaL-like domain; Region: SnoaL_3; pfam13474 247156007103 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035 247156007104 putative uracil binding site [chemical binding]; other site 247156007105 putative active site [active] 247156007106 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 247156007107 catalytic core [active] 247156007108 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 247156007109 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 247156007110 Coenzyme A binding pocket [chemical binding]; other site 247156007111 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 247156007112 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 247156007113 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 247156007114 Predicted flavoprotein [General function prediction only]; Region: COG0431 247156007115 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 247156007116 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 247156007117 SnoaL-like domain; Region: SnoaL_3; pfam13474 247156007118 Epoxide hydrolase N terminus; Region: EHN; pfam06441 247156007119 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 247156007120 Epoxide hydrolase N terminus; Region: EHN; pfam06441 247156007121 HTH domain; Region: HTH_11; pfam08279 247156007122 WYL domain; Region: WYL; pfam13280 247156007123 RibD C-terminal domain; Region: RibD_C; cl17279 247156007124 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156007125 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156007126 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 247156007127 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 247156007128 aromatic arch; other site 247156007129 DCoH dimer interaction site [polypeptide binding]; other site 247156007130 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 247156007131 DCoH tetramer interaction site [polypeptide binding]; other site 247156007132 substrate binding site [chemical binding]; other site 247156007133 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 247156007134 Protein of unknown function (DUF993); Region: DUF993; pfam06187 247156007135 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 247156007136 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 247156007137 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 247156007138 Transcriptional regulators [Transcription]; Region: PurR; COG1609 247156007139 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 247156007140 DNA binding site [nucleotide binding] 247156007141 domain linker motif; other site 247156007142 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 247156007143 dimerization interface [polypeptide binding]; other site 247156007144 ligand binding site [chemical binding]; other site 247156007145 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 247156007146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 247156007147 dimer interface [polypeptide binding]; other site 247156007148 conserved gate region; other site 247156007149 putative PBP binding loops; other site 247156007150 ABC-ATPase subunit interface; other site 247156007151 NMT1/THI5 like; Region: NMT1; pfam09084 247156007152 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 247156007153 membrane-bound complex binding site; other site 247156007154 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 247156007155 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 247156007156 Walker A/P-loop; other site 247156007157 ATP binding site [chemical binding]; other site 247156007158 Q-loop/lid; other site 247156007159 ABC transporter signature motif; other site 247156007160 Walker B; other site 247156007161 D-loop; other site 247156007162 H-loop/switch region; other site 247156007163 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 247156007164 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 247156007165 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 247156007166 HsdM N-terminal domain; Region: HsdM_N; pfam12161 247156007167 Methyltransferase domain; Region: Methyltransf_26; pfam13659 247156007168 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 247156007169 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 247156007170 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 247156007171 Mrr N-terminal domain; Region: Mrr_N; pfam14338 247156007172 Restriction endonuclease; Region: Mrr_cat; pfam04471 247156007173 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 247156007174 AAA domain; Region: AAA_14; pfam13173 247156007175 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 247156007176 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 247156007177 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 247156007178 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 247156007179 ATP binding site [chemical binding]; other site 247156007180 putative Mg++ binding site [ion binding]; other site 247156007181 nucleotide binding region [chemical binding]; other site 247156007182 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 247156007183 ATP-binding site [chemical binding]; other site 247156007184 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 247156007185 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 247156007186 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 247156007187 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 247156007188 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 247156007189 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 247156007190 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 247156007191 dimerization interface [polypeptide binding]; other site 247156007192 putative DNA binding site [nucleotide binding]; other site 247156007193 putative Zn2+ binding site [ion binding]; other site 247156007194 H+ Antiporter protein; Region: 2A0121; TIGR00900 247156007195 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 247156007196 classical (c) SDRs; Region: SDR_c; cd05233 247156007197 NAD(P) binding site [chemical binding]; other site 247156007198 active site 247156007199 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156007200 S-adenosylmethionine binding site [chemical binding]; other site 247156007201 succinic semialdehyde dehydrogenase; Region: PLN02278 247156007202 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 247156007203 tetramerization interface [polypeptide binding]; other site 247156007204 NAD(P) binding site [chemical binding]; other site 247156007205 catalytic residues [active] 247156007206 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 247156007207 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 247156007208 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 247156007209 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 247156007210 tetramer interface [polypeptide binding]; other site 247156007211 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 247156007212 tetramer interface [polypeptide binding]; other site 247156007213 active site 247156007214 metal binding site [ion binding]; metal-binding site 247156007215 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 247156007216 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 247156007217 NAD binding site [chemical binding]; other site 247156007218 catalytic residues [active] 247156007219 Transcriptional regulators [Transcription]; Region: GntR; COG1802 247156007220 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 247156007221 DNA-binding site [nucleotide binding]; DNA binding site 247156007222 FCD domain; Region: FCD; pfam07729 247156007223 hypothetical protein; Provisional; Region: PRK12764 247156007224 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 247156007225 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 247156007226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156007227 metabolite-proton symporter; Region: 2A0106; TIGR00883 247156007228 putative substrate translocation pore; other site 247156007229 phenol 2-monooxygenase; Provisional; Region: PRK08294 247156007230 FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979 247156007231 dimer interface [polypeptide binding]; other site 247156007232 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 247156007233 Bacterial transcriptional regulator; Region: IclR; pfam01614 247156007234 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 247156007235 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 247156007236 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 247156007237 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 247156007238 NAD(P) binding site [chemical binding]; other site 247156007239 catalytic residues [active] 247156007240 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 247156007241 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 247156007242 tyramine oxidase; Provisional; Region: tynA; PRK11504 247156007243 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 247156007244 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 247156007245 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 247156007246 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 247156007247 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156007248 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156007249 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 247156007250 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 247156007251 active site 247156007252 Condensation domain; Region: Condensation; pfam00668 247156007253 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156007254 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 247156007255 acyl-activating enzyme (AAE) consensus motif; other site 247156007256 AMP binding site [chemical binding]; other site 247156007257 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156007258 Condensation domain; Region: Condensation; pfam00668 247156007259 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 247156007260 Condensation domain; Region: Condensation; pfam00668 247156007261 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156007262 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 247156007263 acyl-activating enzyme (AAE) consensus motif; other site 247156007264 AMP binding site [chemical binding]; other site 247156007265 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156007266 Condensation domain; Region: Condensation; pfam00668 247156007267 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156007268 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 247156007269 acyl-activating enzyme (AAE) consensus motif; other site 247156007270 AMP binding site [chemical binding]; other site 247156007271 Condensation domain; Region: Condensation; pfam00668 247156007272 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 247156007273 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 247156007274 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156007275 acyl-activating enzyme (AAE) consensus motif; other site 247156007276 AMP binding site [chemical binding]; other site 247156007277 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156007278 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 247156007279 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 247156007280 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156007281 acyl-activating enzyme (AAE) consensus motif; other site 247156007282 AMP binding site [chemical binding]; other site 247156007283 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156007284 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 247156007285 Zn2+ binding site [ion binding]; other site 247156007286 Mg2+ binding site [ion binding]; other site 247156007287 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 247156007288 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 247156007289 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 247156007290 conserved cys residue [active] 247156007291 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 247156007292 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 247156007293 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156007294 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 247156007295 Domain of unknown function (DUF385); Region: DUF385; cl04387 247156007296 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 247156007297 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 247156007298 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156007299 Walker A/P-loop; other site 247156007300 ATP binding site [chemical binding]; other site 247156007301 Q-loop/lid; other site 247156007302 ABC transporter signature motif; other site 247156007303 Walker B; other site 247156007304 D-loop; other site 247156007305 H-loop/switch region; other site 247156007306 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 247156007307 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156007308 Walker A/P-loop; other site 247156007309 ATP binding site [chemical binding]; other site 247156007310 Q-loop/lid; other site 247156007311 ABC transporter signature motif; other site 247156007312 Walker B; other site 247156007313 D-loop; other site 247156007314 H-loop/switch region; other site 247156007315 FMN binding site [chemical binding]; other site 247156007316 Nitroreductase family; Region: Nitroreductase; pfam00881 247156007317 dimer interface [polypeptide binding]; other site 247156007318 YCII-related domain; Region: YCII; cl00999 247156007319 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 247156007320 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 247156007321 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 247156007322 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 247156007323 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 247156007324 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 247156007325 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 247156007326 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 247156007327 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 247156007328 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 247156007329 dimer interface [polypeptide binding]; other site 247156007330 phosphorylation site [posttranslational modification] 247156007331 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 247156007332 Mg2+ binding site [ion binding]; other site 247156007333 G-X-G motif; other site 247156007334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 247156007335 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 247156007336 active site 247156007337 phosphorylation site [posttranslational modification] 247156007338 intermolecular recognition site; other site 247156007339 dimerization interface [polypeptide binding]; other site 247156007340 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 247156007341 DNA binding site [nucleotide binding] 247156007342 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 247156007343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156007344 putative substrate translocation pore; other site 247156007345 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 247156007346 active site 247156007347 catalytic residues [active] 247156007348 benzoate transport; Region: 2A0115; TIGR00895 247156007349 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156007350 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 247156007351 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 247156007352 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 247156007353 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 247156007354 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 247156007355 CoenzymeA binding site [chemical binding]; other site 247156007356 subunit interaction site [polypeptide binding]; other site 247156007357 PHB binding site; other site 247156007358 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156007359 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 247156007360 Domain of unknown function DUF21; Region: DUF21; pfam01595 247156007361 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 247156007362 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 247156007363 Domain of unknown function DUF21; Region: DUF21; pfam01595 247156007364 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 247156007365 Transporter associated domain; Region: CorC_HlyC; pfam03471 247156007366 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 247156007367 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 247156007368 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 247156007369 DNA binding residues [nucleotide binding] 247156007370 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156007371 S-adenosylmethionine binding site [chemical binding]; other site 247156007372 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 247156007373 Uncharacterized conserved protein [Function unknown]; Region: COG1656 247156007374 Protein of unknown function DUF82; Region: DUF82; pfam01927 247156007375 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 247156007376 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 247156007377 amidase; Provisional; Region: PRK07869 247156007378 Amidase; Region: Amidase; cl11426 247156007379 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 247156007380 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 247156007381 dimerization interface [polypeptide binding]; other site 247156007382 DNA binding residues [nucleotide binding] 247156007383 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 247156007384 dimerization interface [polypeptide binding]; other site 247156007385 putative DNA binding site [nucleotide binding]; other site 247156007386 putative Zn2+ binding site [ion binding]; other site 247156007387 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 247156007388 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 247156007389 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 247156007390 active site 247156007391 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 247156007392 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 247156007393 active site 247156007394 phosphorylation site [posttranslational modification] 247156007395 intermolecular recognition site; other site 247156007396 dimerization interface [polypeptide binding]; other site 247156007397 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 247156007398 DNA binding residues [nucleotide binding] 247156007399 dimerization interface [polypeptide binding]; other site 247156007400 SnoaL-like domain; Region: SnoaL_4; pfam13577 247156007401 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 247156007402 Amidase; Region: Amidase; cl11426 247156007403 Flavin Reductases; Region: FlaRed; cl00801 247156007404 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 247156007405 PAS domain; Region: PAS_9; pfam13426 247156007406 putative active site [active] 247156007407 heme pocket [chemical binding]; other site 247156007408 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 247156007409 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 247156007410 dimer interface [polypeptide binding]; other site 247156007411 phosphorylation site [posttranslational modification] 247156007412 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 247156007413 ATP binding site [chemical binding]; other site 247156007414 Mg2+ binding site [ion binding]; other site 247156007415 G-X-G motif; other site 247156007416 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156007417 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156007418 active site 247156007419 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 247156007420 [2Fe-2S] cluster binding site [ion binding]; other site 247156007421 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 247156007422 putative alpha subunit interface [polypeptide binding]; other site 247156007423 putative active site [active] 247156007424 putative substrate binding site [chemical binding]; other site 247156007425 Fe binding site [ion binding]; other site 247156007426 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 247156007427 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 247156007428 classical (c) SDRs; Region: SDR_c; cd05233 247156007429 NAD(P) binding site [chemical binding]; other site 247156007430 active site 247156007431 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 247156007432 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 247156007433 FMN-binding pocket [chemical binding]; other site 247156007434 flavin binding motif; other site 247156007435 phosphate binding motif [ion binding]; other site 247156007436 beta-alpha-beta structure motif; other site 247156007437 NAD binding pocket [chemical binding]; other site 247156007438 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 247156007439 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 247156007440 catalytic loop [active] 247156007441 iron binding site [ion binding]; other site 247156007442 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 247156007443 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 247156007444 Na binding site [ion binding]; other site 247156007445 MspA; Region: MspA; pfam09203 247156007446 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 247156007447 dimerization domain swap beta strand [polypeptide binding]; other site 247156007448 regulatory protein interface [polypeptide binding]; other site 247156007449 active site 247156007450 regulatory phosphorylation site [posttranslational modification]; other site 247156007451 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 247156007452 active site 247156007453 phosphorylation site [posttranslational modification] 247156007454 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 247156007455 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 247156007456 active site 247156007457 P-loop; other site 247156007458 phosphorylation site [posttranslational modification] 247156007459 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 247156007460 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 247156007461 substrate binding site [chemical binding]; other site 247156007462 ATP binding site [chemical binding]; other site 247156007463 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 247156007464 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 247156007465 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 247156007466 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 247156007467 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 247156007468 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 247156007469 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 247156007470 putative deacylase active site [active] 247156007471 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 247156007472 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 247156007473 DNA binding residues [nucleotide binding] 247156007474 putative dimer interface [polypeptide binding]; other site 247156007475 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 247156007476 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 247156007477 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 247156007478 dinuclear metal binding motif [ion binding]; other site 247156007479 classical (c) SDRs; Region: SDR_c; cd05233 247156007480 short chain dehydrogenase; Provisional; Region: PRK05650 247156007481 NAD(P) binding site [chemical binding]; other site 247156007482 active site 247156007483 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 247156007484 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 247156007485 acyl-activating enzyme (AAE) consensus motif; other site 247156007486 AMP binding site [chemical binding]; other site 247156007487 active site 247156007488 CoA binding site [chemical binding]; other site 247156007489 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156007490 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 247156007491 NAD(P) binding site [chemical binding]; other site 247156007492 active site 247156007493 metabolite-proton symporter; Region: 2A0106; TIGR00883 247156007494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156007495 putative substrate translocation pore; other site 247156007496 Transcriptional regulator [Transcription]; Region: LysR; COG0583 247156007497 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 247156007498 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 247156007499 dimerization interface [polypeptide binding]; other site 247156007500 Uncharacterized conserved protein [Function unknown]; Region: COG5361 247156007501 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 247156007502 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 247156007503 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 247156007504 Helix-turn-helix domain; Region: HTH_28; pfam13518 247156007505 Winged helix-turn helix; Region: HTH_29; pfam13551 247156007506 DDE superfamily endonuclease; Region: DDE_3; pfam13358 247156007507 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 247156007508 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 247156007509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 247156007510 active site 247156007511 phosphorylation site [posttranslational modification] 247156007512 intermolecular recognition site; other site 247156007513 dimerization interface [polypeptide binding]; other site 247156007514 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 247156007515 DNA binding residues [nucleotide binding] 247156007516 dimerization interface [polypeptide binding]; other site 247156007517 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 247156007518 FOG: WD40 repeat [General function prediction only]; Region: COG2319 247156007519 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 247156007520 Putative serine esterase (DUF676); Region: DUF676; pfam05057 247156007521 Recombinase; Region: Recombinase; pfam07508 247156007522 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 247156007523 Winged helix-turn helix; Region: HTH_29; pfam13551 247156007524 Integrase core domain; Region: rve; pfam00665 247156007525 Integrase core domain; Region: rve_3; pfam13683 247156007526 DoxX-like family; Region: DoxX_2; pfam13564 247156007527 Protein of unknown function (DUF664); Region: DUF664; pfam04978 247156007528 DinB superfamily; Region: DinB_2; pfam12867 247156007529 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 247156007530 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 247156007531 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 247156007532 putative NAD(P) binding site [chemical binding]; other site 247156007533 putative substrate binding site [chemical binding]; other site 247156007534 catalytic Zn binding site [ion binding]; other site 247156007535 structural Zn binding site [ion binding]; other site 247156007536 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 247156007537 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 247156007538 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 247156007539 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 247156007540 Histidine kinase; Region: HisKA_3; pfam07730 247156007541 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 247156007542 ATP binding site [chemical binding]; other site 247156007543 Mg2+ binding site [ion binding]; other site 247156007544 G-X-G motif; other site 247156007545 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 247156007546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 247156007547 active site 247156007548 phosphorylation site [posttranslational modification] 247156007549 intermolecular recognition site; other site 247156007550 dimerization interface [polypeptide binding]; other site 247156007551 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 247156007552 DNA binding residues [nucleotide binding] 247156007553 dimerization interface [polypeptide binding]; other site 247156007554 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 247156007555 FMN binding site [chemical binding]; other site 247156007556 dimer interface [polypeptide binding]; other site 247156007557 Universal stress protein family; Region: Usp; pfam00582 247156007558 Domain of unknown function (DUF385); Region: DUF385; pfam04075 247156007559 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 247156007560 molybdopterin cofactor binding site; other site 247156007561 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 247156007562 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 247156007563 Ligand Binding Site [chemical binding]; other site 247156007564 Molecular Tunnel; other site 247156007565 Methyltransferase domain; Region: Methyltransf_31; pfam13847 247156007566 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156007567 S-adenosylmethionine binding site [chemical binding]; other site 247156007568 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 247156007569 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 247156007570 nucleotide binding pocket [chemical binding]; other site 247156007571 K-X-D-G motif; other site 247156007572 catalytic site [active] 247156007573 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 247156007574 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 247156007575 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 247156007576 Dimer interface [polypeptide binding]; other site 247156007577 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 247156007578 hypothetical protein; Provisional; Region: PRK07906 247156007579 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 247156007580 putative metal binding site [ion binding]; other site 247156007581 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 247156007582 substrate binding site [chemical binding]; other site 247156007583 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 247156007584 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 247156007585 acyl-activating enzyme (AAE) consensus motif; other site 247156007586 putative AMP binding site [chemical binding]; other site 247156007587 putative active site [active] 247156007588 putative CoA binding site [chemical binding]; other site 247156007589 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 247156007590 dimerization interface [polypeptide binding]; other site 247156007591 active site 247156007592 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 247156007593 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 247156007594 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 247156007595 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 247156007596 quinone interaction residues [chemical binding]; other site 247156007597 active site 247156007598 catalytic residues [active] 247156007599 FMN binding site [chemical binding]; other site 247156007600 substrate binding site [chemical binding]; other site 247156007601 Uncharacterized conserved protein [Function unknown]; Region: COG3391 247156007602 MMPL family; Region: MMPL; pfam03176 247156007603 MMPL family; Region: MMPL; pfam03176 247156007604 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 247156007605 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156007606 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 247156007607 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156007608 NAD(P) binding site [chemical binding]; other site 247156007609 active site 247156007610 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 247156007611 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 247156007612 Walker A/P-loop; other site 247156007613 ATP binding site [chemical binding]; other site 247156007614 Q-loop/lid; other site 247156007615 ABC transporter signature motif; other site 247156007616 Walker B; other site 247156007617 D-loop; other site 247156007618 H-loop/switch region; other site 247156007619 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 247156007620 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 247156007621 dimer interface [polypeptide binding]; other site 247156007622 putative PBP binding regions; other site 247156007623 ABC-ATPase subunit interface; other site 247156007624 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 247156007625 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 247156007626 intersubunit interface [polypeptide binding]; other site 247156007627 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 247156007628 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 247156007629 active site 247156007630 catalytic tetrad [active] 247156007631 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 247156007632 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 247156007633 catalytic core [active] 247156007634 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 247156007635 conserved hypothetical protein; Region: TIGR03843 247156007636 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 247156007637 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 247156007638 active site 247156007639 HIGH motif; other site 247156007640 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 247156007641 active site 247156007642 KMSKS motif; other site 247156007643 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 247156007644 putative tRNA binding surface [nucleotide binding]; other site 247156007645 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 247156007646 Beta-lactamase; Region: Beta-lactamase; pfam00144 247156007647 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 247156007648 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 247156007649 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 247156007650 DNA binding residues [nucleotide binding] 247156007651 dimer interface [polypeptide binding]; other site 247156007652 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 247156007653 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 247156007654 active site 247156007655 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 247156007656 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 247156007657 active site 247156007658 DNA binding site [nucleotide binding] 247156007659 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 247156007660 DNA binding site [nucleotide binding] 247156007661 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 247156007662 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 247156007663 enoyl-CoA hydratase; Provisional; Region: PRK08252 247156007664 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 247156007665 substrate binding site [chemical binding]; other site 247156007666 oxyanion hole (OAH) forming residues; other site 247156007667 trimer interface [polypeptide binding]; other site 247156007668 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 247156007669 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 247156007670 substrate binding site [chemical binding]; other site 247156007671 oxyanion hole (OAH) forming residues; other site 247156007672 trimer interface [polypeptide binding]; other site 247156007673 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156007674 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156007675 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 247156007676 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 247156007677 putative [Fe4-S4] binding site [ion binding]; other site 247156007678 putative molybdopterin cofactor binding site [chemical binding]; other site 247156007679 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 247156007680 putative molybdopterin cofactor binding site; other site 247156007681 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 247156007682 SnoaL-like domain; Region: SnoaL_2; pfam12680 247156007683 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 247156007684 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 247156007685 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 247156007686 metal binding site 2 [ion binding]; metal-binding site 247156007687 putative DNA binding helix; other site 247156007688 metal binding site 1 [ion binding]; metal-binding site 247156007689 dimer interface [polypeptide binding]; other site 247156007690 structural Zn2+ binding site [ion binding]; other site 247156007691 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 247156007692 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 247156007693 dimer interface [polypeptide binding]; other site 247156007694 active site 247156007695 heme binding site [chemical binding]; other site 247156007696 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 247156007697 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 247156007698 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 247156007699 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 247156007700 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 247156007701 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 247156007702 Fructosamine kinase; Region: Fructosamin_kin; cl17579 247156007703 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 247156007704 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 247156007705 active site 247156007706 catalytic tetrad [active] 247156007707 Predicted transcriptional regulators [Transcription]; Region: COG1733 247156007708 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 247156007709 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 247156007710 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 247156007711 active site 2 [active] 247156007712 active site 1 [active] 247156007713 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 247156007714 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 247156007715 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 247156007716 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 247156007717 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156007718 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156007719 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 247156007720 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156007721 putative substrate translocation pore; other site 247156007722 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 247156007723 Predicted flavoprotein [General function prediction only]; Region: COG0431 247156007724 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 247156007725 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 247156007726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156007727 Transcriptional regulator [Transcription]; Region: LysR; COG0583 247156007728 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 247156007729 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 247156007730 dimerization interface [polypeptide binding]; other site 247156007731 substrate binding pocket [chemical binding]; other site 247156007732 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 247156007733 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156007734 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156007735 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 247156007736 mce related protein; Region: MCE; pfam02470 247156007737 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 247156007738 mce related protein; Region: MCE; pfam02470 247156007739 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 247156007740 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 247156007741 mce related protein; Region: MCE; pfam02470 247156007742 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 247156007743 mce related protein; Region: MCE; pfam02470 247156007744 Permease; Region: Permease; pfam02405 247156007745 Permease; Region: Permease; pfam02405 247156007746 Major Facilitator Superfamily; Region: MFS_1; pfam07690 247156007747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156007748 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156007749 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 247156007750 MarR family; Region: MarR; pfam01047 247156007751 enoyl-CoA hydratase; Provisional; Region: PRK09245 247156007752 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 247156007753 substrate binding site [chemical binding]; other site 247156007754 oxyanion hole (OAH) forming residues; other site 247156007755 trimer interface [polypeptide binding]; other site 247156007756 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 247156007757 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156007758 NADH(P)-binding; Region: NAD_binding_10; pfam13460 247156007759 NAD(P) binding site [chemical binding]; other site 247156007760 active site 247156007761 Cupin; Region: Cupin_6; pfam12852 247156007762 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 247156007763 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 247156007764 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 247156007765 DNA-binding site [nucleotide binding]; DNA binding site 247156007766 RNA-binding motif; other site 247156007767 MarR family; Region: MarR; pfam01047 247156007768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156007769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156007770 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 247156007771 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 247156007772 NAD(P) binding site [chemical binding]; other site 247156007773 catalytic residues [active] 247156007774 Protein of unknown function (DUF779); Region: DUF779; pfam05610 247156007775 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 247156007776 Ligand Binding Site [chemical binding]; other site 247156007777 Low affinity iron permease; Region: Iron_permease; pfam04120 247156007778 short chain dehydrogenase; Provisional; Region: PRK06701 247156007779 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156007780 NAD(P) binding site [chemical binding]; other site 247156007781 active site 247156007782 Protein of unknown function (DUF664); Region: DUF664; pfam04978 247156007783 DinB superfamily; Region: DinB_2; pfam12867 247156007784 Protein of unknown function DUF72; Region: DUF72; pfam01904 247156007785 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 247156007786 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 247156007787 nucleoside/Zn binding site; other site 247156007788 dimer interface [polypeptide binding]; other site 247156007789 catalytic motif [active] 247156007790 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 247156007791 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 247156007792 PYR/PP interface [polypeptide binding]; other site 247156007793 dimer interface [polypeptide binding]; other site 247156007794 TPP binding site [chemical binding]; other site 247156007795 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 247156007796 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 247156007797 TPP-binding site [chemical binding]; other site 247156007798 dimer interface [polypeptide binding]; other site 247156007799 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 247156007800 active site 247156007801 catalytic triad [active] 247156007802 oxyanion hole [active] 247156007803 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 247156007804 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 247156007805 FMN-binding pocket [chemical binding]; other site 247156007806 flavin binding motif; other site 247156007807 phosphate binding motif [ion binding]; other site 247156007808 beta-alpha-beta structure motif; other site 247156007809 NAD binding pocket [chemical binding]; other site 247156007810 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 247156007811 catalytic loop [active] 247156007812 iron binding site [ion binding]; other site 247156007813 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 247156007814 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 247156007815 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 247156007816 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 247156007817 acyl-CoA synthetase; Validated; Region: PRK08316 247156007818 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 247156007819 acyl-activating enzyme (AAE) consensus motif; other site 247156007820 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 247156007821 putative AMP binding site [chemical binding]; other site 247156007822 putative active site [active] 247156007823 acyl-activating enzyme (AAE) consensus motif; other site 247156007824 putative CoA binding site [chemical binding]; other site 247156007825 RNHCP domain; Region: RNHCP; pfam12647 247156007826 RNHCP domain; Region: RNHCP; pfam12647 247156007827 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 247156007828 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 247156007829 DNA-binding site [nucleotide binding]; DNA binding site 247156007830 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 247156007831 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 247156007832 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 247156007833 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 247156007834 substrate binding site [chemical binding]; other site 247156007835 oxyanion hole (OAH) forming residues; other site 247156007836 trimer interface [polypeptide binding]; other site 247156007837 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 247156007838 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 247156007839 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 247156007840 Coenzyme A binding pocket [chemical binding]; other site 247156007841 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 247156007842 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 247156007843 DNA binding residues [nucleotide binding] 247156007844 Condensation domain; Region: Condensation; pfam00668 247156007845 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156007846 Major Facilitator Superfamily; Region: MFS_1; pfam07690 247156007847 putative substrate translocation pore; other site 247156007848 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 247156007849 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 247156007850 active site 247156007851 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 247156007852 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 247156007853 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156007854 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 247156007855 Enoylreductase; Region: PKS_ER; smart00829 247156007856 NAD(P) binding site [chemical binding]; other site 247156007857 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156007858 KR domain; Region: KR; pfam08659 247156007859 NAD(P) binding site [chemical binding]; other site 247156007860 active site 247156007861 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 247156007862 Putative esterase; Region: Esterase; pfam00756 247156007863 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156007864 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156007865 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 247156007866 HTH domain; Region: HTH_11; pfam08279 247156007867 WYL domain; Region: WYL; pfam13280 247156007868 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156007869 Walker A/P-loop; other site 247156007870 ATP binding site [chemical binding]; other site 247156007871 Q-loop/lid; other site 247156007872 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 247156007873 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156007874 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 247156007875 Walker A/P-loop; other site 247156007876 ATP binding site [chemical binding]; other site 247156007877 Q-loop/lid; other site 247156007878 ABC transporter signature motif; other site 247156007879 Walker B; other site 247156007880 D-loop; other site 247156007881 H-loop/switch region; other site 247156007882 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 247156007883 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156007884 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156007885 short chain dehydrogenase; Provisional; Region: PRK12744 247156007886 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 247156007887 NADP binding site [chemical binding]; other site 247156007888 homodimer interface [polypeptide binding]; other site 247156007889 active site 247156007890 substrate binding site [chemical binding]; other site 247156007891 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 247156007892 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 247156007893 active site 247156007894 phosphorylation site [posttranslational modification] 247156007895 intermolecular recognition site; other site 247156007896 dimerization interface [polypeptide binding]; other site 247156007897 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 247156007898 DNA binding residues [nucleotide binding] 247156007899 dimerization interface [polypeptide binding]; other site 247156007900 Histidine kinase; Region: HisKA_3; pfam07730 247156007901 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 247156007902 Transcriptional regulator [Transcription]; Region: LysR; COG0583 247156007903 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 247156007904 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 247156007905 dimerization interface [polypeptide binding]; other site 247156007906 2-isopropylmalate synthase; Validated; Region: PRK03739 247156007907 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 247156007908 active site 247156007909 catalytic residues [active] 247156007910 metal binding site [ion binding]; metal-binding site 247156007911 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 247156007912 Ligand Binding Site [chemical binding]; other site 247156007913 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 247156007914 Ligand Binding Site [chemical binding]; other site 247156007915 Transcriptional regulator [Transcription]; Region: IclR; COG1414 247156007916 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 247156007917 Bacterial transcriptional regulator; Region: IclR; pfam01614 247156007918 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 247156007919 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 247156007920 Tautomerase enzyme; Region: Tautomerase; pfam01361 247156007921 active site 1 [active] 247156007922 dimer interface [polypeptide binding]; other site 247156007923 hexamer interface [polypeptide binding]; other site 247156007924 active site 2 [active] 247156007925 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156007926 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156007927 active site 247156007928 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 247156007929 active site 247156007930 metal binding site [ion binding]; metal-binding site 247156007931 MarR family; Region: MarR_2; pfam12802 247156007932 N-terminal, non-catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_N_like; cd09013 247156007933 tetramer interface [polypeptide binding]; other site 247156007934 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 247156007935 C-terminal, catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_C_like; cd09014 247156007936 tetramer interface [polypeptide binding]; other site 247156007937 active site 247156007938 metal binding site [ion binding]; metal-binding site 247156007939 acetaldehyde dehydrogenase; Validated; Region: PRK08300 247156007940 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 247156007941 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 247156007942 4-hydroxy-2-oxovalerate aldolase; Region: 4OH_2_O_val_ald; TIGR03217 247156007943 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 247156007944 active site 247156007945 metal binding site [ion binding]; metal-binding site 247156007946 DmpG-like communication domain; Region: DmpG_comm; pfam07836 247156007947 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 247156007948 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 247156007949 NAD binding site [chemical binding]; other site 247156007950 catalytic residues [active] 247156007951 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156007952 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 247156007953 NAD(P) binding site [chemical binding]; other site 247156007954 active site 247156007955 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 247156007956 hexamer interface [polypeptide binding]; other site 247156007957 active site 2 [active] 247156007958 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 247156007959 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 247156007960 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 247156007961 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 247156007962 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 247156007963 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 247156007964 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 247156007965 catalytic loop [active] 247156007966 iron binding site [ion binding]; other site 247156007967 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 247156007968 FAD binding pocket [chemical binding]; other site 247156007969 FAD binding motif [chemical binding]; other site 247156007970 phosphate binding motif [ion binding]; other site 247156007971 beta-alpha-beta structure motif; other site 247156007972 NAD binding pocket [chemical binding]; other site 247156007973 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 247156007974 Cytochrome P450; Region: p450; cl12078 247156007975 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 247156007976 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 247156007977 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 247156007978 putative hydrophobic ligand binding site [chemical binding]; other site 247156007979 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156007980 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 247156007981 NAD(P) binding site [chemical binding]; other site 247156007982 active site 247156007983 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 247156007984 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 247156007985 DNA binding residues [nucleotide binding] 247156007986 B12 binding domain; Region: B12-binding_2; cl03653 247156007987 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 247156007988 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 247156007989 DNA photolyase; Region: DNA_photolyase; pfam00875 247156007990 Protein of unknown function (DUF461); Region: DUF461; pfam04314 247156007991 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 247156007992 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 247156007993 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 247156007994 Transcriptional regulator [Transcription]; Region: LysR; COG0583 247156007995 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 247156007996 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 247156007997 dimerization interface [polypeptide binding]; other site 247156007998 Transcriptional regulator [Transcription]; Region: LysR; COG0583 247156007999 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 247156008000 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 247156008001 putative dimerization interface [polypeptide binding]; other site 247156008002 EamA-like transporter family; Region: EamA; cl17759 247156008003 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156008004 NADH(P)-binding; Region: NAD_binding_10; pfam13460 247156008005 NAD(P) binding site [chemical binding]; other site 247156008006 active site 247156008007 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 247156008008 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 247156008009 putative NAD(P) binding site [chemical binding]; other site 247156008010 catalytic Zn binding site [ion binding]; other site 247156008011 acetoin reductases; Region: 23BDH; TIGR02415 247156008012 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156008013 NAD(P) binding site [chemical binding]; other site 247156008014 active site 247156008015 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156008016 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156008017 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 247156008018 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 247156008019 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 247156008020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 247156008021 dimer interface [polypeptide binding]; other site 247156008022 conserved gate region; other site 247156008023 putative PBP binding loops; other site 247156008024 ABC-ATPase subunit interface; other site 247156008025 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 247156008026 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 247156008027 Walker A/P-loop; other site 247156008028 ATP binding site [chemical binding]; other site 247156008029 Q-loop/lid; other site 247156008030 ABC transporter signature motif; other site 247156008031 Walker B; other site 247156008032 D-loop; other site 247156008033 H-loop/switch region; other site 247156008034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 247156008035 putative PBP binding loops; other site 247156008036 dimer interface [polypeptide binding]; other site 247156008037 ABC-ATPase subunit interface; other site 247156008038 hypothetical protein; Validated; Region: PRK07121 247156008039 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 247156008040 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 247156008041 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 247156008042 FMN binding site [chemical binding]; other site 247156008043 substrate binding site [chemical binding]; other site 247156008044 putative catalytic residue [active] 247156008045 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 247156008046 putative hydrophobic ligand binding site [chemical binding]; other site 247156008047 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 247156008048 hydrophobic ligand binding site; other site 247156008049 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 247156008050 putative DNA binding site [nucleotide binding]; other site 247156008051 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 247156008052 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 247156008053 Predicted transcriptional regulators [Transcription]; Region: COG1695 247156008054 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 247156008055 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 247156008056 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 247156008057 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 247156008058 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 247156008059 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 247156008060 FAD binding pocket [chemical binding]; other site 247156008061 FAD binding motif [chemical binding]; other site 247156008062 phosphate binding motif [ion binding]; other site 247156008063 beta-alpha-beta structure motif; other site 247156008064 NAD binding pocket [chemical binding]; other site 247156008065 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 247156008066 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 247156008067 catalytic loop [active] 247156008068 iron binding site [ion binding]; other site 247156008069 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 247156008070 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 247156008071 putative active site [active] 247156008072 putative dimer interface [polypeptide binding]; other site 247156008073 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 247156008074 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 247156008075 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 247156008076 DNA binding residues [nucleotide binding] 247156008077 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 247156008078 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 247156008079 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 247156008080 acyl-activating enzyme (AAE) consensus motif; other site 247156008081 acyl-activating enzyme (AAE) consensus motif; other site 247156008082 putative AMP binding site [chemical binding]; other site 247156008083 putative active site [active] 247156008084 putative CoA binding site [chemical binding]; other site 247156008085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156008086 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156008087 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156008088 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 247156008089 short chain dehydrogenase; Provisional; Region: PRK06172 247156008090 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156008091 classical (c) SDRs; Region: SDR_c; cd05233 247156008092 NAD(P) binding site [chemical binding]; other site 247156008093 active site 247156008094 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156008095 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156008096 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 247156008097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156008098 putative substrate translocation pore; other site 247156008099 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 247156008100 putative DNA binding site [nucleotide binding]; other site 247156008101 dimerization interface [polypeptide binding]; other site 247156008102 putative Zn2+ binding site [ion binding]; other site 247156008103 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 247156008104 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 247156008105 Soluble P-type ATPase [General function prediction only]; Region: COG4087 247156008106 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 247156008107 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 247156008108 dimer interface [polypeptide binding]; other site 247156008109 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 247156008110 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 247156008111 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 247156008112 putative active site [active] 247156008113 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 247156008114 dimerization interface [polypeptide binding]; other site 247156008115 putative DNA binding site [nucleotide binding]; other site 247156008116 putative Zn2+ binding site [ion binding]; other site 247156008117 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 247156008118 Peptidase family M23; Region: Peptidase_M23; pfam01551 247156008119 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 247156008120 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 247156008121 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 247156008122 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156008123 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 247156008124 Walker A/P-loop; other site 247156008125 ATP binding site [chemical binding]; other site 247156008126 Q-loop/lid; other site 247156008127 ABC transporter signature motif; other site 247156008128 Walker B; other site 247156008129 D-loop; other site 247156008130 H-loop/switch region; other site 247156008131 Condensation domain; Region: Condensation; pfam00668 247156008132 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156008133 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 247156008134 acyl-activating enzyme (AAE) consensus motif; other site 247156008135 AMP binding site [chemical binding]; other site 247156008136 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156008137 Condensation domain; Region: Condensation; pfam00668 247156008138 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 247156008139 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156008140 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 247156008141 acyl-activating enzyme (AAE) consensus motif; other site 247156008142 AMP binding site [chemical binding]; other site 247156008143 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156008144 Condensation domain; Region: Condensation; pfam00668 247156008145 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 247156008146 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 247156008147 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156008148 acyl-activating enzyme (AAE) consensus motif; other site 247156008149 AMP binding site [chemical binding]; other site 247156008150 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 247156008151 Condensation domain; Region: Condensation; pfam00668 247156008152 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 247156008153 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 247156008154 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156008155 acyl-activating enzyme (AAE) consensus motif; other site 247156008156 AMP binding site [chemical binding]; other site 247156008157 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156008158 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 247156008159 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 247156008160 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 247156008161 putative active site [active] 247156008162 catalytic triad [active] 247156008163 putative dimer interface [polypeptide binding]; other site 247156008164 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 247156008165 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 247156008166 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 247156008167 active site 247156008168 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 247156008169 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 247156008170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 247156008171 active site 247156008172 phosphorylation site [posttranslational modification] 247156008173 intermolecular recognition site; other site 247156008174 dimerization interface [polypeptide binding]; other site 247156008175 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 247156008176 DNA binding residues [nucleotide binding] 247156008177 dimerization interface [polypeptide binding]; other site 247156008178 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 247156008179 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 247156008180 Histidine kinase; Region: HisKA_3; pfam07730 247156008181 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 247156008182 ATP binding site [chemical binding]; other site 247156008183 Mg2+ binding site [ion binding]; other site 247156008184 G-X-G motif; other site 247156008185 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 247156008186 hypothetical protein; Provisional; Region: PRK10621 247156008187 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156008188 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 247156008189 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 247156008190 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 247156008191 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 247156008192 Predicted transcriptional regulators [Transcription]; Region: COG1695 247156008193 Transcriptional regulator PadR-like family; Region: PadR; cl17335 247156008194 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 247156008195 active site 247156008196 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 247156008197 active site 247156008198 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 247156008199 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156008200 sequence-specific DNA binding site [nucleotide binding]; other site 247156008201 salt bridge; other site 247156008202 Phosphotransferase enzyme family; Region: APH; pfam01636 247156008203 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 247156008204 active site 247156008205 ATP binding site [chemical binding]; other site 247156008206 Secretory lipase; Region: LIP; pfam03583 247156008207 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 247156008208 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 247156008209 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 247156008210 SnoaL-like domain; Region: SnoaL_4; pfam13577 247156008211 precorrin-3B synthase; Region: CobG; TIGR02435 247156008212 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 247156008213 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156008214 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156008215 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 247156008216 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 247156008217 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156008218 Walker A/P-loop; other site 247156008219 ATP binding site [chemical binding]; other site 247156008220 Q-loop/lid; other site 247156008221 ABC transporter signature motif; other site 247156008222 Walker B; other site 247156008223 D-loop; other site 247156008224 H-loop/switch region; other site 247156008225 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156008226 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 247156008227 Walker A/P-loop; other site 247156008228 ATP binding site [chemical binding]; other site 247156008229 Q-loop/lid; other site 247156008230 ABC transporter signature motif; other site 247156008231 Walker B; other site 247156008232 D-loop; other site 247156008233 H-loop/switch region; other site 247156008234 muropeptide transporter; Validated; Region: ampG; cl17669 247156008235 Uncharacterized conserved protein [Function unknown]; Region: COG3189 247156008236 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 247156008237 GTP cyclohydrolase I; Provisional; Region: PLN03044 247156008238 active site 247156008239 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 247156008240 Predicted transcriptional regulator [Transcription]; Region: COG2345 247156008241 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 247156008242 putative Zn2+ binding site [ion binding]; other site 247156008243 putative DNA binding site [nucleotide binding]; other site 247156008244 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 247156008245 Precorrin-8X methylmutase; Region: CbiC; pfam02570 247156008246 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 247156008247 active site 247156008248 SAM binding site [chemical binding]; other site 247156008249 homodimer interface [polypeptide binding]; other site 247156008250 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 247156008251 homodimer interface [polypeptide binding]; other site 247156008252 active site 247156008253 SAM binding site [chemical binding]; other site 247156008254 Predicted transcriptional regulators [Transcription]; Region: COG1695 247156008255 Transcriptional regulator PadR-like family; Region: PadR; cl17335 247156008256 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 247156008257 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 247156008258 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 247156008259 active site 247156008260 SAM binding site [chemical binding]; other site 247156008261 putative homodimer interface [polypeptide binding]; other site 247156008262 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 247156008263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156008264 S-adenosylmethionine binding site [chemical binding]; other site 247156008265 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156008266 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 247156008267 NAD(P) binding site [chemical binding]; other site 247156008268 active site 247156008269 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 247156008270 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 247156008271 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 247156008272 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 247156008273 active site 247156008274 5'-3' exonuclease (including N-terminal domain of PolI) [DNA replication, recombination, and repair]; Region: Exo; COG0258 247156008275 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 247156008276 active site 247156008277 metal binding site 1 [ion binding]; metal-binding site 247156008278 putative 5' ssDNA interaction site; other site 247156008279 metal binding site 3; metal-binding site 247156008280 metal binding site 2 [ion binding]; metal-binding site 247156008281 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 247156008282 putative DNA binding site [nucleotide binding]; other site 247156008283 putative metal binding site [ion binding]; other site 247156008284 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 247156008285 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 247156008286 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 247156008287 ATP binding site [chemical binding]; other site 247156008288 putative Mg++ binding site [ion binding]; other site 247156008289 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 247156008290 ATP-binding site [chemical binding]; other site 247156008291 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 247156008292 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 247156008293 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 247156008294 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 247156008295 2-dehydropantoate 2-reductase; Provisional; Region: PRK08229 247156008296 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 247156008297 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 247156008298 Predicted transcriptional regulator [Transcription]; Region: COG2378 247156008299 WYL domain; Region: WYL; pfam13280 247156008300 Predicted transcriptional regulator [Transcription]; Region: COG2378 247156008301 WYL domain; Region: WYL; pfam13280 247156008302 Domain of unknown function DUF77; Region: DUF77; pfam01910 247156008303 SnoaL-like domain; Region: SnoaL_3; pfam13474 247156008304 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 247156008305 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 247156008306 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 247156008307 active site 247156008308 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 247156008309 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 247156008310 active site 247156008311 Pup-like protein; Region: Pup; pfam05639 247156008312 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 247156008313 Predicted membrane protein [Function unknown]; Region: COG2311 247156008314 Protein of unknown function (DUF418); Region: DUF418; cl12135 247156008315 Protein of unknown function (DUF418); Region: DUF418; pfam04235 247156008316 Helix-turn-helix domain; Region: HTH_18; pfam12833 247156008317 Domain of unknown function (DUF385); Region: DUF385; cl04387 247156008318 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 247156008319 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 247156008320 ArsC family; Region: ArsC; pfam03960 247156008321 catalytic residues [active] 247156008322 proteasome ATPase; Region: pup_AAA; TIGR03689 247156008323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 247156008324 Walker A motif; other site 247156008325 ATP binding site [chemical binding]; other site 247156008326 Walker B motif; other site 247156008327 arginine finger; other site 247156008328 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 247156008329 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156008330 S-adenosylmethionine binding site [chemical binding]; other site 247156008331 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 247156008332 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 247156008333 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 247156008334 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 247156008335 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 247156008336 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 247156008337 homodimer interface [polypeptide binding]; other site 247156008338 putative metal binding site [ion binding]; other site 247156008339 Choline/Carnitine o-acyltransferase; Region: Carn_acyltransf; pfam00755 247156008340 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 247156008341 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 247156008342 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 247156008343 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 247156008344 motif II; other site 247156008345 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 247156008346 Catalytic domain of Protein Kinases; Region: PKc; cd00180 247156008347 active site 247156008348 ATP binding site [chemical binding]; other site 247156008349 substrate binding site [chemical binding]; other site 247156008350 activation loop (A-loop); other site 247156008351 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 247156008352 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 247156008353 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 247156008354 substrate binding pocket [chemical binding]; other site 247156008355 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 247156008356 B12 binding site [chemical binding]; other site 247156008357 cobalt ligand [ion binding]; other site 247156008358 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 247156008359 PAC2 family; Region: PAC2; pfam09754 247156008360 TIGR02677 family protein; Region: TIGR02677 247156008361 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 247156008362 Protein of unknown function (DUF2398); Region: DUF2398; cl09875 247156008363 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 247156008364 metabolite-proton symporter; Region: 2A0106; TIGR00883 247156008365 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 247156008366 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 247156008367 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 247156008368 active site 247156008369 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 247156008370 substrate binding site [chemical binding]; other site 247156008371 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 247156008372 ATP binding site [chemical binding]; other site 247156008373 fumarate hydratase; Provisional; Region: PRK15389 247156008374 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 247156008375 Fumarase C-terminus; Region: Fumerase_C; pfam05683 247156008376 Transcriptional regulators [Transcription]; Region: MarR; COG1846 247156008377 MarR family; Region: MarR_2; pfam12802 247156008378 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 247156008379 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 247156008380 phosphate binding site [ion binding]; other site 247156008381 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 247156008382 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 247156008383 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156008384 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 247156008385 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 247156008386 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 247156008387 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 247156008388 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 247156008389 PAS domain S-box; Region: sensory_box; TIGR00229 247156008390 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 247156008391 putative active site [active] 247156008392 heme pocket [chemical binding]; other site 247156008393 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 247156008394 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 247156008395 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 247156008396 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 247156008397 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 247156008398 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 247156008399 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 247156008400 acyl-activating enzyme (AAE) consensus motif; other site 247156008401 putative AMP binding site [chemical binding]; other site 247156008402 putative active site [active] 247156008403 putative CoA binding site [chemical binding]; other site 247156008404 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 247156008405 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 247156008406 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 247156008407 Lipase (class 2); Region: Lipase_2; pfam01674 247156008408 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 247156008409 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 247156008410 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 247156008411 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 247156008412 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 247156008413 conserved cys residue [active] 247156008414 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 247156008415 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 247156008416 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 247156008417 methionine sulfoxide reductase A; Provisional; Region: PRK14054 247156008418 HTH domain; Region: HTH_11; pfam08279 247156008419 Predicted transcriptional regulator [Transcription]; Region: COG2378 247156008420 WYL domain; Region: WYL; pfam13280 247156008421 Protein of unknown function (DUF664); Region: DUF664; pfam04978 247156008422 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 247156008423 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156008424 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 247156008425 NAD(P) binding site [chemical binding]; other site 247156008426 active site 247156008427 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 247156008428 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 247156008429 Metal-binding active site; metal-binding site 247156008430 metabolite-proton symporter; Region: 2A0106; TIGR00883 247156008431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156008432 putative substrate translocation pore; other site 247156008433 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 247156008434 TPP-binding site [chemical binding]; other site 247156008435 dimer interface [polypeptide binding]; other site 247156008436 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 247156008437 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 247156008438 PYR/PP interface [polypeptide binding]; other site 247156008439 dimer interface [polypeptide binding]; other site 247156008440 TPP binding site [chemical binding]; other site 247156008441 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 247156008442 Transcriptional regulators [Transcription]; Region: GntR; COG1802 247156008443 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 247156008444 DNA-binding site [nucleotide binding]; DNA binding site 247156008445 FCD domain; Region: FCD; pfam07729 247156008446 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156008447 enoyl-CoA hydratase; Provisional; Region: PRK12478 247156008448 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 247156008449 substrate binding site [chemical binding]; other site 247156008450 oxyanion hole (OAH) forming residues; other site 247156008451 trimer interface [polypeptide binding]; other site 247156008452 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 247156008453 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 247156008454 putative active site [active] 247156008455 putative CoA binding site [chemical binding]; other site 247156008456 nudix motif; other site 247156008457 metal binding site [ion binding]; metal-binding site 247156008458 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 247156008459 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156008460 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 247156008461 Putative esterase; Region: Esterase; pfam00756 247156008462 Transcriptional regulator [Transcription]; Region: IclR; COG1414 247156008463 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 247156008464 Helix-turn-helix domain; Region: HTH_18; pfam12833 247156008465 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 247156008466 EthD domain; Region: EthD; cl17553 247156008467 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 247156008468 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 247156008469 classical (c) SDRs; Region: SDR_c; cd05233 247156008470 NAD(P) binding site [chemical binding]; other site 247156008471 active site 247156008472 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 247156008473 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 247156008474 dimer interface [polypeptide binding]; other site 247156008475 conserved gate region; other site 247156008476 putative PBP binding loops; other site 247156008477 ABC-ATPase subunit interface; other site 247156008478 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 247156008479 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 247156008480 Walker A/P-loop; other site 247156008481 ATP binding site [chemical binding]; other site 247156008482 Q-loop/lid; other site 247156008483 ABC transporter signature motif; other site 247156008484 Walker B; other site 247156008485 D-loop; other site 247156008486 H-loop/switch region; other site 247156008487 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 247156008488 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 247156008489 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 247156008490 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 247156008491 Cutinase; Region: Cutinase; pfam01083 247156008492 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 247156008493 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 247156008494 Secretory lipase; Region: LIP; pfam03583 247156008495 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 247156008496 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 247156008497 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 247156008498 putative active site [active] 247156008499 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 247156008500 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 247156008501 substrate binding pocket [chemical binding]; other site 247156008502 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 247156008503 Transcriptional regulator [Transcription]; Region: LysR; COG0583 247156008504 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 247156008505 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 247156008506 substrate binding pocket [chemical binding]; other site 247156008507 dimerization interface [polypeptide binding]; other site 247156008508 Amidohydrolase; Region: Amidohydro_2; pfam04909 247156008509 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 247156008510 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 247156008511 NAD(P) binding site [chemical binding]; other site 247156008512 catalytic residues [active] 247156008513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156008514 metabolite-proton symporter; Region: 2A0106; TIGR00883 247156008515 putative substrate translocation pore; other site 247156008516 Putative cyclase; Region: Cyclase; pfam04199 247156008517 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 247156008518 Predicted amidohydrolase [General function prediction only]; Region: COG0388 247156008519 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 247156008520 putative active site [active] 247156008521 catalytic triad [active] 247156008522 putative dimer interface [polypeptide binding]; other site 247156008523 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 247156008524 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 247156008525 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 247156008526 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 247156008527 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 247156008528 Cupin domain; Region: Cupin_2; pfam07883 247156008529 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 247156008530 homotrimer interaction site [polypeptide binding]; other site 247156008531 hypothetical protein; Provisional; Region: PRK07236 247156008532 hypothetical protein; Provisional; Region: PRK08244 247156008533 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 247156008534 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156008535 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 247156008536 arginine deiminase; Provisional; Region: PRK01388 247156008537 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 247156008538 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 247156008539 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 247156008540 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 247156008541 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 247156008542 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 247156008543 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 247156008544 DNA binding residues [nucleotide binding] 247156008545 dimerization interface [polypeptide binding]; other site 247156008546 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 247156008547 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 247156008548 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 247156008549 PAS domain; Region: PAS_9; pfam13426 247156008550 putative active site [active] 247156008551 heme pocket [chemical binding]; other site 247156008552 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 247156008553 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 247156008554 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 247156008555 Domain of unknown function (DUF718); Region: DUF718; pfam05336 247156008556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156008557 putative substrate translocation pore; other site 247156008558 L-rhamnose isomerase, Streptomyces subtype; Region: RhaI_grampos; TIGR02635 247156008559 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 247156008560 short chain dehydrogenase; Validated; Region: PRK08324 247156008561 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 247156008562 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156008563 NAD(P) binding site [chemical binding]; other site 247156008564 active site 247156008565 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 247156008566 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 247156008567 nucleotide binding site [chemical binding]; other site 247156008568 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 247156008569 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 247156008570 phosphate binding site [ion binding]; other site 247156008571 Transcriptional regulators [Transcription]; Region: PurR; COG1609 247156008572 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 247156008573 DNA binding site [nucleotide binding] 247156008574 domain linker motif; other site 247156008575 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 247156008576 ligand binding site [chemical binding]; other site 247156008577 dimerization interface [polypeptide binding]; other site 247156008578 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156008579 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156008580 acyl-CoA synthetase; Provisional; Region: PRK13388 247156008581 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 247156008582 acyl-activating enzyme (AAE) consensus motif; other site 247156008583 putative AMP binding site [chemical binding]; other site 247156008584 putative active site [active] 247156008585 putative CoA binding site [chemical binding]; other site 247156008586 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 247156008587 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 247156008588 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 247156008589 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 247156008590 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 247156008591 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156008592 hypothetical protein; Provisional; Region: PRK07236 247156008593 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 247156008594 SnoaL-like domain; Region: SnoaL_2; pfam12680 247156008595 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 247156008596 Winged helix-turn helix; Region: HTH_29; pfam13551 247156008597 Integrase core domain; Region: rve; pfam00665 247156008598 Integrase core domain; Region: rve_3; pfam13683 247156008599 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 247156008600 active site 247156008601 metal binding site [ion binding]; metal-binding site 247156008602 Predicted transcriptional regulator [Transcription]; Region: COG2944 247156008603 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 247156008604 RibD C-terminal domain; Region: RibD_C; cl17279 247156008605 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 247156008606 catalytic motif [active] 247156008607 Zn binding site [ion binding]; other site 247156008608 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 247156008609 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 247156008610 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 247156008611 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156008612 Walker A/P-loop; other site 247156008613 ATP binding site [chemical binding]; other site 247156008614 Q-loop/lid; other site 247156008615 ABC transporter signature motif; other site 247156008616 Walker B; other site 247156008617 D-loop; other site 247156008618 H-loop/switch region; other site 247156008619 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 247156008620 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 247156008621 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156008622 Walker A/P-loop; other site 247156008623 ATP binding site [chemical binding]; other site 247156008624 Q-loop/lid; other site 247156008625 ABC transporter signature motif; other site 247156008626 Walker B; other site 247156008627 D-loop; other site 247156008628 H-loop/switch region; other site 247156008629 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156008630 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156008631 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 247156008632 Transcriptional regulator [Transcription]; Region: IclR; COG1414 247156008633 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 247156008634 Bacterial transcriptional regulator; Region: IclR; pfam01614 247156008635 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 247156008636 acetaldehyde dehydrogenase; Validated; Region: PRK08300 247156008637 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 247156008638 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 247156008639 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 247156008640 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 247156008641 active site 247156008642 catalytic residues [active] 247156008643 metal binding site [ion binding]; metal-binding site 247156008644 DmpG-like communication domain; Region: DmpG_comm; pfam07836 247156008645 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 247156008646 Fatty acid desaturase; Region: FA_desaturase; pfam00487 247156008647 Di-iron ligands [ion binding]; other site 247156008648 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 247156008649 S-formylglutathione hydrolase; Region: PLN02442 247156008650 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 247156008651 short chain dehydrogenase; Provisional; Region: PRK07454 247156008652 NADP binding site [chemical binding]; other site 247156008653 substrate binding site [chemical binding]; other site 247156008654 active site 247156008655 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 247156008656 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156008657 amidase; Provisional; Region: PRK07869 247156008658 Amidase; Region: Amidase; cl11426 247156008659 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 247156008660 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 247156008661 putative NAD(P) binding site [chemical binding]; other site 247156008662 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 247156008663 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 247156008664 Predicted ATPase [General function prediction only]; Region: COG3899 247156008665 AAA ATPase domain; Region: AAA_16; pfam13191 247156008666 Hemerythrin-like domain; Region: Hr-like; cd12108 247156008667 Fe binding site [ion binding]; other site 247156008668 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 247156008669 NIPSNAP; Region: NIPSNAP; pfam07978 247156008670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156008671 putative substrate translocation pore; other site 247156008672 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 247156008673 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 247156008674 DNA binding residues [nucleotide binding] 247156008675 dimer interface [polypeptide binding]; other site 247156008676 [2Fe-2S] cluster binding site [ion binding]; other site 247156008677 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 247156008678 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 247156008679 Coenzyme A binding pocket [chemical binding]; other site 247156008680 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 247156008681 dimerization interface [polypeptide binding]; other site 247156008682 putative DNA binding site [nucleotide binding]; other site 247156008683 putative Zn2+ binding site [ion binding]; other site 247156008684 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 247156008685 active site residue [active] 247156008686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156008687 Major Facilitator Superfamily; Region: MFS_1; pfam07690 247156008688 MspA; Region: MspA; pfam09203 247156008689 MspA; Region: MspA; pfam09203 247156008690 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 247156008691 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 247156008692 active site 247156008693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156008694 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 247156008695 Domain of unknown function (DUF385); Region: DUF385; pfam04075 247156008696 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 247156008697 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 247156008698 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 247156008699 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156008700 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 247156008701 NAD(P) binding site [chemical binding]; other site 247156008702 active site 247156008703 SnoaL-like domain; Region: SnoaL_4; pfam13577 247156008704 Transcriptional regulator [Transcription]; Region: IclR; COG1414 247156008705 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 247156008706 Bacterial transcriptional regulator; Region: IclR; pfam01614 247156008707 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 247156008708 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 247156008709 inhibitor-cofactor binding pocket; inhibition site 247156008710 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156008711 catalytic residue [active] 247156008712 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 247156008713 Cytochrome P450; Region: p450; cl12078 247156008714 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 247156008715 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 247156008716 metabolite-proton symporter; Region: 2A0106; TIGR00883 247156008717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156008718 putative substrate translocation pore; other site 247156008719 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 247156008720 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156008721 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156008722 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 247156008723 NAD(P) binding site [chemical binding]; other site 247156008724 active site 247156008725 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 247156008726 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 247156008727 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 247156008728 hydrophobic ligand binding site; other site 247156008729 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 247156008730 active site 247156008731 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156008732 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 247156008733 Flavin binding site [chemical binding]; other site 247156008734 SnoaL-like domain; Region: SnoaL_2; pfam12680 247156008735 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 247156008736 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 247156008737 Walker A/P-loop; other site 247156008738 ATP binding site [chemical binding]; other site 247156008739 Q-loop/lid; other site 247156008740 ABC transporter signature motif; other site 247156008741 Walker B; other site 247156008742 D-loop; other site 247156008743 H-loop/switch region; other site 247156008744 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 247156008745 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 247156008746 TM-ABC transporter signature motif; other site 247156008747 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 247156008748 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 247156008749 TM-ABC transporter signature motif; other site 247156008750 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 247156008751 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 247156008752 Walker A/P-loop; other site 247156008753 ATP binding site [chemical binding]; other site 247156008754 Q-loop/lid; other site 247156008755 ABC transporter signature motif; other site 247156008756 Walker B; other site 247156008757 D-loop; other site 247156008758 H-loop/switch region; other site 247156008759 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 247156008760 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 247156008761 putative ligand binding site [chemical binding]; other site 247156008762 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 247156008763 CoenzymeA binding site [chemical binding]; other site 247156008764 subunit interaction site [polypeptide binding]; other site 247156008765 PHB binding site; other site 247156008766 Transcriptional regulator [Transcription]; Region: IclR; COG1414 247156008767 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 247156008768 Bacterial transcriptional regulator; Region: IclR; pfam01614 247156008769 Predicted transcriptional regulators [Transcription]; Region: COG1695 247156008770 Transcriptional regulator PadR-like family; Region: PadR; cl17335 247156008771 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 247156008772 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 247156008773 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 247156008774 active site 247156008775 FMN binding site [chemical binding]; other site 247156008776 substrate binding site [chemical binding]; other site 247156008777 putative catalytic residue [active] 247156008778 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 247156008779 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 247156008780 hypothetical protein; Provisional; Region: PRK06194 247156008781 classical (c) SDRs; Region: SDR_c; cd05233 247156008782 NAD(P) binding site [chemical binding]; other site 247156008783 active site 247156008784 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 247156008785 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156008786 NAD(P) binding site [chemical binding]; other site 247156008787 active site 247156008788 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156008789 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156008790 active site 247156008791 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 247156008792 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 247156008793 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 247156008794 Transcriptional regulator [Transcription]; Region: IclR; COG1414 247156008795 Bacterial transcriptional regulator; Region: IclR; pfam01614 247156008796 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 247156008797 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 247156008798 hypothetical protein; Provisional; Region: PRK06194 247156008799 classical (c) SDRs; Region: SDR_c; cd05233 247156008800 NAD(P) binding site [chemical binding]; other site 247156008801 active site 247156008802 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 247156008803 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 247156008804 active site 247156008805 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 247156008806 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156008807 NAD(P) binding site [chemical binding]; other site 247156008808 active site 247156008809 enoyl-CoA hydratase; Provisional; Region: PRK05870 247156008810 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 247156008811 substrate binding site [chemical binding]; other site 247156008812 oxyanion hole (OAH) forming residues; other site 247156008813 trimer interface [polypeptide binding]; other site 247156008814 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156008815 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156008816 active site 247156008817 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 247156008818 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 247156008819 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156008820 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 247156008821 CoA-transferase family III; Region: CoA_transf_3; pfam02515 247156008822 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 247156008823 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 247156008824 DNA-binding site [nucleotide binding]; DNA binding site 247156008825 FCD domain; Region: FCD; pfam07729 247156008826 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 247156008827 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 247156008828 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 247156008829 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 247156008830 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 247156008831 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 247156008832 catalytic loop [active] 247156008833 iron binding site [ion binding]; other site 247156008834 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 247156008835 Cytochrome P450; Region: p450; cl12078 247156008836 short chain dehydrogenase; Provisional; Region: PRK07791 247156008837 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156008838 NAD(P) binding site [chemical binding]; other site 247156008839 active site 247156008840 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 247156008841 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 247156008842 active site 247156008843 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 247156008844 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 247156008845 CysD dimerization site [polypeptide binding]; other site 247156008846 G1 box; other site 247156008847 putative GEF interaction site [polypeptide binding]; other site 247156008848 GTP/Mg2+ binding site [chemical binding]; other site 247156008849 Switch I region; other site 247156008850 G2 box; other site 247156008851 G3 box; other site 247156008852 Switch II region; other site 247156008853 G4 box; other site 247156008854 G5 box; other site 247156008855 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 247156008856 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 247156008857 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 247156008858 ligand-binding site [chemical binding]; other site 247156008859 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 247156008860 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 247156008861 Active Sites [active] 247156008862 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 247156008863 classical (c) SDRs; Region: SDR_c; cd05233 247156008864 NAD(P) binding site [chemical binding]; other site 247156008865 active site 247156008866 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 247156008867 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 247156008868 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 247156008869 NAD(P) binding site [chemical binding]; other site 247156008870 Transcriptional regulator [Transcription]; Region: IclR; COG1414 247156008871 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 247156008872 Bacterial transcriptional regulator; Region: IclR; pfam01614 247156008873 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 247156008874 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 247156008875 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 247156008876 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 247156008877 MFS/sugar transport protein; Region: MFS_2; pfam13347 247156008878 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 247156008879 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 247156008880 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 247156008881 Transcriptional regulators [Transcription]; Region: PurR; COG1609 247156008882 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 247156008883 DNA binding site [nucleotide binding] 247156008884 domain linker motif; other site 247156008885 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 247156008886 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156008887 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156008888 active site 247156008889 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 247156008890 putative active site [active] 247156008891 ATP binding site [chemical binding]; other site 247156008892 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 247156008893 putative active site [active] 247156008894 putative catalytic site [active] 247156008895 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 247156008896 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156008897 NAD(P) binding site [chemical binding]; other site 247156008898 active site 247156008899 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 247156008900 classical (c) SDRs; Region: SDR_c; cd05233 247156008901 NAD(P) binding site [chemical binding]; other site 247156008902 active site 247156008903 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 247156008904 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 247156008905 dimer interface [polypeptide binding]; other site 247156008906 active site 247156008907 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156008908 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156008909 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 247156008910 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 247156008911 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156008912 putative substrate translocation pore; other site 247156008913 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 247156008914 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 247156008915 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 247156008916 Proteins of 100 residues with WXG; Region: WXG100; cl02005 247156008917 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 247156008918 anti sigma factor interaction site; other site 247156008919 regulatory phosphorylation site [posttranslational modification]; other site 247156008920 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 247156008921 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 247156008922 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 247156008923 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 247156008924 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 247156008925 active site 247156008926 DNA binding site [nucleotide binding] 247156008927 Int/Topo IB signature motif; other site 247156008928 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 247156008929 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 247156008930 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 247156008931 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 247156008932 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 247156008933 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain; Region: THF_DHG_CYH_C; pfam02882 247156008934 NAD(P) binding pocket [chemical binding]; other site 247156008935 Uncharacterized conserved protein [Function unknown]; Region: COG1434 247156008936 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 247156008937 putative active site [active] 247156008938 putative protein-(glutamine-N5) methyltransferase, unknown substrate-specific; Region: PrmC_rel_meth; TIGR03704 247156008939 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 247156008940 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 247156008941 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156008942 NAD(P) binding site [chemical binding]; other site 247156008943 active site 247156008944 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 247156008945 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 247156008946 NAD(P) binding site [chemical binding]; other site 247156008947 catalytic residues [active] 247156008948 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156008949 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156008950 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 247156008951 DNA-binding site [nucleotide binding]; DNA binding site 247156008952 RNA-binding motif; other site 247156008953 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 247156008954 DNA-directed RNA polymerase, alpha subunit/40 kD subunit [Transcription]; Region: RpoA; COG0202 247156008955 mycofactocin precursor; Region: mycofactocin; TIGR03969 247156008956 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 247156008957 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 247156008958 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 247156008959 FeS/SAM binding site; other site 247156008960 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 247156008961 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 247156008962 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 247156008963 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 247156008964 Predicted ATPase [General function prediction only]; Region: COG3903 247156008965 ABC-2 type transporter; Region: ABC2_membrane; cl17235 247156008966 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 247156008967 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156008968 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 247156008969 Walker A/P-loop; other site 247156008970 ATP binding site [chemical binding]; other site 247156008971 Q-loop/lid; other site 247156008972 ABC transporter signature motif; other site 247156008973 Walker B; other site 247156008974 D-loop; other site 247156008975 H-loop/switch region; other site 247156008976 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156008977 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156008978 active site 247156008979 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156008980 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156008981 active site 247156008982 short chain dehydrogenase; Provisional; Region: PRK05872 247156008983 classical (c) SDRs; Region: SDR_c; cd05233 247156008984 NAD(P) binding site [chemical binding]; other site 247156008985 active site 247156008986 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 247156008987 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 247156008988 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 247156008989 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 247156008990 FMN-binding pocket [chemical binding]; other site 247156008991 flavin binding motif; other site 247156008992 phosphate binding motif [ion binding]; other site 247156008993 beta-alpha-beta structure motif; other site 247156008994 NAD binding pocket [chemical binding]; other site 247156008995 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 247156008996 catalytic loop [active] 247156008997 iron binding site [ion binding]; other site 247156008998 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 247156008999 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 247156009000 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156009001 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156009002 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 247156009003 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 247156009004 active site 247156009005 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 247156009006 active site 247156009007 peptide synthase; Provisional; Region: PRK09274 247156009008 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_1; cd05910 247156009009 acyl-activating enzyme (AAE) consensus motif; other site 247156009010 putative AMP binding site [chemical binding]; other site 247156009011 putative active site [active] 247156009012 putative CoA binding site [chemical binding]; other site 247156009013 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 247156009014 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156009015 NAD(P) binding site [chemical binding]; other site 247156009016 active site 247156009017 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 247156009018 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 247156009019 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 247156009020 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156009021 non-specific DNA binding site [nucleotide binding]; other site 247156009022 salt bridge; other site 247156009023 sequence-specific DNA binding site [nucleotide binding]; other site 247156009024 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 247156009025 nudix motif; other site 247156009026 membrane ATPase/protein kinase; Provisional; Region: PRK09435 247156009027 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 247156009028 Walker A; other site 247156009029 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 247156009030 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 247156009031 active site 247156009032 substrate binding site [chemical binding]; other site 247156009033 coenzyme B12 binding site [chemical binding]; other site 247156009034 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 247156009035 B12 binding site [chemical binding]; other site 247156009036 cobalt ligand [ion binding]; other site 247156009037 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 247156009038 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 247156009039 heterodimer interface [polypeptide binding]; other site 247156009040 substrate interaction site [chemical binding]; other site 247156009041 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 247156009042 Uncharacterized conserved protein [Function unknown]; Region: COG0398 247156009043 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 247156009044 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 247156009045 oligomer interface [polypeptide binding]; other site 247156009046 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 247156009047 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 247156009048 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 247156009049 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 247156009050 ferrochelatase; Reviewed; Region: hemH; PRK00035 247156009051 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 247156009052 C-terminal domain interface [polypeptide binding]; other site 247156009053 active site 247156009054 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 247156009055 active site 247156009056 N-terminal domain interface [polypeptide binding]; other site 247156009057 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 247156009058 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156009059 NAD(P) binding site [chemical binding]; other site 247156009060 active site 247156009061 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156009062 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 247156009063 NAD(P) binding site [chemical binding]; other site 247156009064 active site 247156009065 hypothetical protein; Provisional; Region: PRK13685 247156009066 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 247156009067 von Willebrand factor type A domain; Region: VWA_2; pfam13519 247156009068 metal ion-dependent adhesion site (MIDAS); other site 247156009069 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 247156009070 Protein of unknown function DUF58; Region: DUF58; pfam01882 247156009071 MoxR-like ATPases [General function prediction only]; Region: COG0714 247156009072 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 247156009073 Walker A motif; other site 247156009074 ATP binding site [chemical binding]; other site 247156009075 Walker B motif; other site 247156009076 arginine finger; other site 247156009077 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 247156009078 NlpC/P60 family; Region: NLPC_P60; pfam00877 247156009079 aconitate hydratase; Validated; Region: PRK09277 247156009080 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 247156009081 substrate binding site [chemical binding]; other site 247156009082 ligand binding site [chemical binding]; other site 247156009083 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 247156009084 substrate binding site [chemical binding]; other site 247156009085 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156009086 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156009087 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 247156009088 active site 1 [active] 247156009089 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 247156009090 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 247156009091 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156009092 Walker A/P-loop; other site 247156009093 ATP binding site [chemical binding]; other site 247156009094 Q-loop/lid; other site 247156009095 ABC transporter signature motif; other site 247156009096 Walker B; other site 247156009097 D-loop; other site 247156009098 H-loop/switch region; other site 247156009099 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 247156009100 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 247156009101 classical (c) SDRs; Region: SDR_c; cd05233 247156009102 NAD(P) binding site [chemical binding]; other site 247156009103 active site 247156009104 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 247156009105 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 247156009106 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 247156009107 putative DNA binding site [nucleotide binding]; other site 247156009108 putative homodimer interface [polypeptide binding]; other site 247156009109 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 247156009110 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 247156009111 spermidine synthase; Provisional; Region: PRK03612 247156009112 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156009113 Predicted acyl esterases [General function prediction only]; Region: COG2936 247156009114 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 247156009115 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 247156009116 ATP-grasp domain; Region: ATP-grasp_4; cl17255 247156009117 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 247156009118 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 247156009119 FMN binding site [chemical binding]; other site 247156009120 substrate binding site [chemical binding]; other site 247156009121 putative catalytic residue [active] 247156009122 Domain of unknown function (DUF385); Region: DUF385; cl04387 247156009123 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 247156009124 Cytochrome P450; Region: p450; cl12078 247156009125 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 247156009126 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156009127 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156009128 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 247156009129 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 247156009130 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 247156009131 dimer interface [polypeptide binding]; other site 247156009132 NADP binding site [chemical binding]; other site 247156009133 catalytic residues [active] 247156009134 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 247156009135 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 247156009136 putative active site [active] 247156009137 catalytic residue [active] 247156009138 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 247156009139 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 247156009140 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447 247156009141 putative dimerization interface [polypeptide binding]; other site 247156009142 putative substrate binding pocket [chemical binding]; other site 247156009143 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 247156009144 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156009145 putative substrate translocation pore; other site 247156009146 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 247156009147 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 247156009148 active site 247156009149 tetramer interface [polypeptide binding]; other site 247156009150 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 247156009151 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156009152 Q-loop/lid; other site 247156009153 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 247156009154 ABC transporter signature motif; other site 247156009155 Walker B; other site 247156009156 D-loop; other site 247156009157 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 247156009158 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 247156009159 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 247156009160 NAD binding site [chemical binding]; other site 247156009161 substrate binding site [chemical binding]; other site 247156009162 catalytic Zn binding site [ion binding]; other site 247156009163 structural Zn binding site [ion binding]; other site 247156009164 YCII-related domain; Region: YCII; cl00999 247156009165 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 247156009166 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 247156009167 RNA polymerase factor sigma-70; Validated; Region: PRK08241 247156009168 Glucose dehydrogenase; Region: glucose_DH; cd08230 247156009169 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 247156009170 NADP binding site [chemical binding]; other site 247156009171 catalytic Zn binding site [ion binding]; other site 247156009172 structural Zn binding site [ion binding]; other site 247156009173 dimer interface [polypeptide binding]; other site 247156009174 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156009175 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156009176 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 247156009177 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 247156009178 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 247156009179 acyl-activating enzyme (AAE) consensus motif; other site 247156009180 acyl-activating enzyme (AAE) consensus motif; other site 247156009181 putative AMP binding site [chemical binding]; other site 247156009182 putative active site [active] 247156009183 putative CoA binding site [chemical binding]; other site 247156009184 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 247156009185 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 247156009186 dimer interface [polypeptide binding]; other site 247156009187 active site 247156009188 Coenzyme A transferase; Region: CoA_trans; cl17247 247156009189 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 247156009190 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 247156009191 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 247156009192 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 247156009193 dimerization interface [polypeptide binding]; other site 247156009194 substrate binding pocket [chemical binding]; other site 247156009195 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 247156009196 Muconate lactonizing enzyme (MLE) like subgroup of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and residues that can...; Region: MLE_like; cd03315 247156009197 active site 247156009198 catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438 247156009199 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 247156009200 active site 247156009201 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 247156009202 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 247156009203 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 247156009204 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 247156009205 Bacterial transcriptional regulator; Region: IclR; pfam01614 247156009206 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 247156009207 hydroxyglutarate oxidase; Provisional; Region: PRK11728 247156009208 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 247156009209 catalytic Zn binding site [ion binding]; other site 247156009210 structural Zn binding site [ion binding]; other site 247156009211 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 247156009212 putative phosphonate catabolism associated alcohol dehydrogenase; Region: HpnZ_proposed; TIGR03366 247156009213 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 247156009214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 247156009215 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 247156009216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 247156009217 dimer interface [polypeptide binding]; other site 247156009218 conserved gate region; other site 247156009219 putative PBP binding loops; other site 247156009220 ABC-ATPase subunit interface; other site 247156009221 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 247156009222 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156009223 Walker A/P-loop; other site 247156009224 ATP binding site [chemical binding]; other site 247156009225 Q-loop/lid; other site 247156009226 ABC transporter signature motif; other site 247156009227 Walker B; other site 247156009228 D-loop; other site 247156009229 H-loop/switch region; other site 247156009230 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 247156009231 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 247156009232 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 247156009233 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 247156009234 DNA-binding site [nucleotide binding]; DNA binding site 247156009235 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 247156009236 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156009237 sequence-specific DNA binding site [nucleotide binding]; other site 247156009238 salt bridge; other site 247156009239 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 247156009240 hypothetical protein; Provisional; Region: PRK06834 247156009241 hypothetical protein; Provisional; Region: PRK07236 247156009242 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 247156009243 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 247156009244 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156009245 Walker A/P-loop; other site 247156009246 ATP binding site [chemical binding]; other site 247156009247 ABC transporter signature motif; other site 247156009248 Walker B; other site 247156009249 D-loop; other site 247156009250 H-loop/switch region; other site 247156009251 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 247156009252 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 247156009253 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156009254 catalytic residue [active] 247156009255 acyl-CoA synthetase; Provisional; Region: PRK13391 247156009256 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 247156009257 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 247156009258 acyl-activating enzyme (AAE) consensus motif; other site 247156009259 putative AMP binding site [chemical binding]; other site 247156009260 putative active site [active] 247156009261 putative CoA binding site [chemical binding]; other site 247156009262 metabolite-proton symporter; Region: 2A0106; TIGR00883 247156009263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156009264 putative substrate translocation pore; other site 247156009265 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156009266 active site 247156009267 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 247156009268 Phosphotransferase enzyme family; Region: APH; pfam01636 247156009269 putative active site [active] 247156009270 putative substrate binding site [chemical binding]; other site 247156009271 ATP binding site [chemical binding]; other site 247156009272 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156009273 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156009274 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156009275 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156009276 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156009277 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156009278 active site 247156009279 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 247156009280 dimerization interface [polypeptide binding]; other site 247156009281 putative DNA binding site [nucleotide binding]; other site 247156009282 putative Zn2+ binding site [ion binding]; other site 247156009283 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 247156009284 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 247156009285 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 247156009286 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 247156009287 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 247156009288 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 247156009289 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 247156009290 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 247156009291 trimerization site [polypeptide binding]; other site 247156009292 active site 247156009293 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 247156009294 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 247156009295 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 247156009296 catalytic residue [active] 247156009297 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 247156009298 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 247156009299 Walker A/P-loop; other site 247156009300 ATP binding site [chemical binding]; other site 247156009301 Q-loop/lid; other site 247156009302 ABC transporter signature motif; other site 247156009303 Walker B; other site 247156009304 D-loop; other site 247156009305 H-loop/switch region; other site 247156009306 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 247156009307 FeS assembly protein SufD; Region: sufD; TIGR01981 247156009308 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 247156009309 FeS assembly protein SufB; Region: sufB; TIGR01980 247156009310 Predicted transcriptional regulator [Transcription]; Region: COG2345 247156009311 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 247156009312 putative DNA binding site [nucleotide binding]; other site 247156009313 putative Zn2+ binding site [ion binding]; other site 247156009314 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 247156009315 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 247156009316 NAD(P) binding site [chemical binding]; other site 247156009317 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156009318 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156009319 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 247156009320 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 247156009321 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 247156009322 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 247156009323 Walker A/P-loop; other site 247156009324 ATP binding site [chemical binding]; other site 247156009325 Q-loop/lid; other site 247156009326 ABC transporter signature motif; other site 247156009327 Walker B; other site 247156009328 D-loop; other site 247156009329 H-loop/switch region; other site 247156009330 ABC-2 type transporter; Region: ABC2_membrane; cl17235 247156009331 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 247156009332 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 247156009333 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 247156009334 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 247156009335 Ligand Binding Site [chemical binding]; other site 247156009336 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 247156009337 Ligand Binding Site [chemical binding]; other site 247156009338 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 247156009339 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 247156009340 NADP binding site [chemical binding]; other site 247156009341 dimer interface [polypeptide binding]; other site 247156009342 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 247156009343 UbiA prenyltransferase family; Region: UbiA; pfam01040 247156009344 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 247156009345 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 247156009346 TPP-binding site [chemical binding]; other site 247156009347 dimer interface [polypeptide binding]; other site 247156009348 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 247156009349 PYR/PP interface [polypeptide binding]; other site 247156009350 dimer interface [polypeptide binding]; other site 247156009351 TPP binding site [chemical binding]; other site 247156009352 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 247156009353 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 247156009354 putative active site [active] 247156009355 transaldolase; Provisional; Region: PRK03903 247156009356 catalytic residue [active] 247156009357 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 247156009358 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 247156009359 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 247156009360 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 247156009361 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 247156009362 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 247156009363 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 247156009364 putative active site [active] 247156009365 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 247156009366 tetramer interface [polypeptide binding]; other site 247156009367 TPP-binding site [chemical binding]; other site 247156009368 heterodimer interface [polypeptide binding]; other site 247156009369 phosphorylation loop region [posttranslational modification] 247156009370 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 247156009371 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 247156009372 PYR/PP interface [polypeptide binding]; other site 247156009373 dimer interface [polypeptide binding]; other site 247156009374 TPP binding site [chemical binding]; other site 247156009375 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 247156009376 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 247156009377 hydrophobic ligand binding site; other site 247156009378 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 247156009379 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156009380 putative substrate translocation pore; other site 247156009381 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 247156009382 short chain dehydrogenase; Provisional; Region: PRK08303 247156009383 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156009384 NAD(P) binding site [chemical binding]; other site 247156009385 active site 247156009386 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 247156009387 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 247156009388 Transmembrane secretion effector; Region: MFS_3; pfam05977 247156009389 META domain; Region: META; pfam03724 247156009390 triosephosphate isomerase; Provisional; Region: PRK14567 247156009391 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 247156009392 substrate binding site [chemical binding]; other site 247156009393 dimer interface [polypeptide binding]; other site 247156009394 catalytic triad [active] 247156009395 Phosphoglycerate kinase; Region: PGK; pfam00162 247156009396 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 247156009397 substrate binding site [chemical binding]; other site 247156009398 hinge regions; other site 247156009399 ADP binding site [chemical binding]; other site 247156009400 catalytic site [active] 247156009401 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 247156009402 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 247156009403 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 247156009404 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 247156009405 Coenzyme A binding pocket [chemical binding]; other site 247156009406 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 247156009407 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 247156009408 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 247156009409 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 247156009410 phosphate binding site [ion binding]; other site 247156009411 putative substrate binding pocket [chemical binding]; other site 247156009412 dimer interface [polypeptide binding]; other site 247156009413 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 247156009414 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 247156009415 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 247156009416 GIY-YIG motif/motif A; other site 247156009417 active site 247156009418 catalytic site [active] 247156009419 putative DNA binding site [nucleotide binding]; other site 247156009420 metal binding site [ion binding]; metal-binding site 247156009421 UvrB/uvrC motif; Region: UVR; pfam02151 247156009422 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 247156009423 Helix-hairpin-helix motif; Region: HHH; pfam00633 247156009424 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 247156009425 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 247156009426 motif II; other site 247156009427 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 247156009428 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 247156009429 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 247156009430 homodimer interface [polypeptide binding]; other site 247156009431 substrate-cofactor binding pocket; other site 247156009432 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156009433 catalytic residue [active] 247156009434 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 247156009435 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 247156009436 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 247156009437 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 247156009438 homopentamer interface [polypeptide binding]; other site 247156009439 active site 247156009440 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 247156009441 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 247156009442 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 247156009443 dimerization interface [polypeptide binding]; other site 247156009444 active site 247156009445 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 247156009446 Lumazine binding domain; Region: Lum_binding; pfam00677 247156009447 Lumazine binding domain; Region: Lum_binding; pfam00677 247156009448 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 247156009449 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 247156009450 substrate binding site [chemical binding]; other site 247156009451 hexamer interface [polypeptide binding]; other site 247156009452 metal binding site [ion binding]; metal-binding site 247156009453 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 247156009454 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 247156009455 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 247156009456 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 247156009457 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 247156009458 DNA binding residues [nucleotide binding] 247156009459 Protein of unknown function (DUF419); Region: DUF419; pfam04237 247156009460 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 247156009461 putative RNA binding site [nucleotide binding]; other site 247156009462 16S rRNA methyltransferase B; Provisional; Region: PRK14902 247156009463 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156009464 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 247156009465 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 247156009466 putative active site [active] 247156009467 substrate binding site [chemical binding]; other site 247156009468 putative cosubstrate binding site; other site 247156009469 catalytic site [active] 247156009470 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 247156009471 substrate binding site [chemical binding]; other site 247156009472 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 247156009473 active site 247156009474 catalytic residues [active] 247156009475 metal binding site [ion binding]; metal-binding site 247156009476 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 247156009477 Lipase (class 2); Region: Lipase_2; pfam01674 247156009478 Predicted transcriptional regulators [Transcription]; Region: COG1695 247156009479 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 247156009480 primosome assembly protein PriA; Provisional; Region: PRK14873 247156009481 S-adenosylmethionine synthetase; Validated; Region: PRK05250 247156009482 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 247156009483 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 247156009484 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 247156009485 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 247156009486 Flavoprotein; Region: Flavoprotein; pfam02441 247156009487 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 247156009488 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 247156009489 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 247156009490 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 247156009491 catalytic site [active] 247156009492 G-X2-G-X-G-K; other site 247156009493 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 247156009494 active site 247156009495 dimer interface [polypeptide binding]; other site 247156009496 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 247156009497 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 247156009498 ATP-grasp domain; Region: ATP-grasp_4; cl17255 247156009499 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 247156009500 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 247156009501 ATP-grasp domain; Region: ATP-grasp_4; cl17255 247156009502 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 247156009503 IMP binding site; other site 247156009504 dimer interface [polypeptide binding]; other site 247156009505 interdomain contacts; other site 247156009506 partial ornithine binding site; other site 247156009507 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 247156009508 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 247156009509 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 247156009510 catalytic site [active] 247156009511 subunit interface [polypeptide binding]; other site 247156009512 dihydroorotase; Validated; Region: pyrC; PRK09357 247156009513 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 247156009514 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 247156009515 active site 247156009516 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 247156009517 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 247156009518 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 247156009519 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 247156009520 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 247156009521 active site 247156009522 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 247156009523 Leucine carboxyl methyltransferase; Region: LCM; cl01306 247156009524 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 247156009525 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 247156009526 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156009527 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 247156009528 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 247156009529 NAD(P) binding site [chemical binding]; other site 247156009530 YCII-related domain; Region: YCII; cl00999 247156009531 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 247156009532 putative RNA binding site [nucleotide binding]; other site 247156009533 elongation factor P; Validated; Region: PRK00529 247156009534 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 247156009535 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 247156009536 RNA binding site [nucleotide binding]; other site 247156009537 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 247156009538 RNA binding site [nucleotide binding]; other site 247156009539 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 247156009540 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 247156009541 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 247156009542 active site 247156009543 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 247156009544 chorismate synthase; Validated; Region: PRK05382 247156009545 Tetramer interface [polypeptide binding]; other site 247156009546 active site 247156009547 FMN-binding site [chemical binding]; other site 247156009548 shikimate kinase; Reviewed; Region: aroK; PRK00131 247156009549 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 247156009550 ADP binding site [chemical binding]; other site 247156009551 magnesium binding site [ion binding]; other site 247156009552 putative shikimate binding site; other site 247156009553 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 247156009554 active site 247156009555 dimer interface [polypeptide binding]; other site 247156009556 metal binding site [ion binding]; metal-binding site 247156009557 hypothetical protein; Provisional; Region: PRK07236 247156009558 hypothetical protein; Provisional; Region: PRK07588 247156009559 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156009560 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 247156009561 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 247156009562 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 247156009563 NAD(P) binding site [chemical binding]; other site 247156009564 shikimate binding site; other site 247156009565 YceG-like family; Region: YceG; pfam02618 247156009566 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 247156009567 dimerization interface [polypeptide binding]; other site 247156009568 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 247156009569 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 247156009570 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 247156009571 motif 1; other site 247156009572 active site 247156009573 motif 2; other site 247156009574 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 247156009575 motif 3; other site 247156009576 motif 3; other site 247156009577 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 247156009578 DHHA1 domain; Region: DHHA1; pfam02272 247156009579 recombination factor protein RarA; Reviewed; Region: PRK13342 247156009580 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 247156009581 Walker A motif; other site 247156009582 ATP binding site [chemical binding]; other site 247156009583 Walker B motif; other site 247156009584 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 247156009585 PhoD-like phosphatase; Region: PhoD; pfam09423 247156009586 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 247156009587 putative active site [active] 247156009588 putative metal binding site [ion binding]; other site 247156009589 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 247156009590 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 247156009591 substrate binding site [chemical binding]; other site 247156009592 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 247156009593 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 247156009594 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 247156009595 dimer interface [polypeptide binding]; other site 247156009596 anticodon binding site; other site 247156009597 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 247156009598 homodimer interface [polypeptide binding]; other site 247156009599 motif 1; other site 247156009600 active site 247156009601 motif 2; other site 247156009602 GAD domain; Region: GAD; pfam02938 247156009603 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 247156009604 active site 247156009605 motif 3; other site 247156009606 Predicted metalloprotease [General function prediction only]; Region: COG2321 247156009607 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 247156009608 EspG family; Region: ESX-1_EspG; pfam14011 247156009609 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 247156009610 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 247156009611 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 247156009612 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 247156009613 putative NADP binding site [chemical binding]; other site 247156009614 putative substrate binding site [chemical binding]; other site 247156009615 active site 247156009616 Radical SAM superfamily; Region: Radical_SAM; pfam04055 247156009617 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 247156009618 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 247156009619 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 247156009620 dimer interface [polypeptide binding]; other site 247156009621 PYR/PP interface [polypeptide binding]; other site 247156009622 TPP binding site [chemical binding]; other site 247156009623 substrate binding site [chemical binding]; other site 247156009624 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 247156009625 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 247156009626 TPP-binding site [chemical binding]; other site 247156009627 malate dehydrogenase; Provisional; Region: PRK05442 247156009628 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 247156009629 NAD(P) binding site [chemical binding]; other site 247156009630 dimer interface [polypeptide binding]; other site 247156009631 malate binding site [chemical binding]; other site 247156009632 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 247156009633 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 247156009634 motif 1; other site 247156009635 dimer interface [polypeptide binding]; other site 247156009636 active site 247156009637 motif 2; other site 247156009638 motif 3; other site 247156009639 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 247156009640 anticodon binding site; other site 247156009641 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 247156009642 active site 247156009643 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 247156009644 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 247156009645 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 247156009646 Peptidase family M23; Region: Peptidase_M23; pfam01551 247156009647 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 247156009648 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 247156009649 N-acetyl-D-glucosamine binding site [chemical binding]; other site 247156009650 catalytic residue [active] 247156009651 NlpC/P60 family; Region: NLPC_P60; cl17555 247156009652 AAA-like domain; Region: AAA_10; pfam12846 247156009653 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 247156009654 Cutinase; Region: Cutinase; pfam01083 247156009655 hypothetical protein; Provisional; Region: PRK02237 247156009656 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 247156009657 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 247156009658 Zn2+ binding site [ion binding]; other site 247156009659 Mg2+ binding site [ion binding]; other site 247156009660 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 247156009661 synthetase active site [active] 247156009662 NTP binding site [chemical binding]; other site 247156009663 metal binding site [ion binding]; metal-binding site 247156009664 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 247156009665 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 247156009666 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 247156009667 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 247156009668 heme-binding site [chemical binding]; other site 247156009669 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 247156009670 FAD binding pocket [chemical binding]; other site 247156009671 FAD binding motif [chemical binding]; other site 247156009672 phosphate binding motif [ion binding]; other site 247156009673 beta-alpha-beta structure motif; other site 247156009674 NAD binding pocket [chemical binding]; other site 247156009675 Heme binding pocket [chemical binding]; other site 247156009676 Predicted transcriptional regulator [Transcription]; Region: COG1959 247156009677 Transcriptional regulator; Region: Rrf2; cl17282 247156009678 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 247156009679 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156009680 Walker A/P-loop; other site 247156009681 ATP binding site [chemical binding]; other site 247156009682 ABC transporter signature motif; other site 247156009683 Walker B; other site 247156009684 D-loop; other site 247156009685 H-loop/switch region; other site 247156009686 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 247156009687 adenine phosphoribosyltransferase; Provisional; Region: PRK02304 247156009688 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 247156009689 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 247156009690 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 247156009691 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 247156009692 Protein export membrane protein; Region: SecD_SecF; pfam02355 247156009693 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 247156009694 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 247156009695 Preprotein translocase subunit; Region: YajC; pfam02699 247156009696 DivIVA domain; Region: DivI1A_domain; TIGR03544 247156009697 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 247156009698 DivIVA domain; Region: DivI1A_domain; TIGR03544 247156009699 DivIVA domain; Region: DivI1A_domain; TIGR03544 247156009700 DivIVA domain; Region: DivI1A_domain; TIGR03544 247156009701 Predicted membrane protein [Function unknown]; Region: COG2246 247156009702 GtrA-like protein; Region: GtrA; pfam04138 247156009703 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 247156009704 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 247156009705 Walker A motif; other site 247156009706 ATP binding site [chemical binding]; other site 247156009707 Walker B motif; other site 247156009708 arginine finger; other site 247156009709 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 247156009710 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 247156009711 RuvA N terminal domain; Region: RuvA_N; pfam01330 247156009712 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 247156009713 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 247156009714 active site 247156009715 putative DNA-binding cleft [nucleotide binding]; other site 247156009716 dimer interface [polypeptide binding]; other site 247156009717 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 247156009718 putative ADP-ribose binding site [chemical binding]; other site 247156009719 putative active site [active] 247156009720 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 247156009721 putative DNA binding site [nucleotide binding]; other site 247156009722 putative Zn2+ binding site [ion binding]; other site 247156009723 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 247156009724 putative hydrophobic ligand binding site [chemical binding]; other site 247156009725 hypothetical protein; Validated; Region: PRK00110 247156009726 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 247156009727 imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; Region: IMP_synth_hisH; TIGR01855 247156009728 predicted active site [active] 247156009729 catalytic triad [active] 247156009730 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 247156009731 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 247156009732 active site 247156009733 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 247156009734 catalytic triad [active] 247156009735 dimer interface [polypeptide binding]; other site 247156009736 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 247156009737 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 247156009738 active site 247156009739 multimer interface [polypeptide binding]; other site 247156009740 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 247156009741 nudix motif; other site 247156009742 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 247156009743 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 247156009744 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 247156009745 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 247156009746 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 247156009747 putative acyl-acceptor binding pocket; other site 247156009748 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 247156009749 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 247156009750 nucleotide binding site/active site [active] 247156009751 HIT family signature motif; other site 247156009752 catalytic residue [active] 247156009753 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 247156009754 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 247156009755 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 247156009756 active site 247156009757 dimer interface [polypeptide binding]; other site 247156009758 motif 1; other site 247156009759 motif 2; other site 247156009760 motif 3; other site 247156009761 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 247156009762 anticodon binding site; other site 247156009763 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 247156009764 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 247156009765 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 247156009766 Sulfate transporter family; Region: Sulfate_transp; pfam00916 247156009767 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 247156009768 active site clefts [active] 247156009769 zinc binding site [ion binding]; other site 247156009770 dimer interface [polypeptide binding]; other site 247156009771 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156009772 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156009773 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 247156009774 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 247156009775 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 247156009776 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156009777 Walker A/P-loop; other site 247156009778 ATP binding site [chemical binding]; other site 247156009779 Q-loop/lid; other site 247156009780 ABC transporter signature motif; other site 247156009781 Walker B; other site 247156009782 D-loop; other site 247156009783 H-loop/switch region; other site 247156009784 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 247156009785 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 247156009786 ATP binding site [chemical binding]; other site 247156009787 Mg2+ binding site [ion binding]; other site 247156009788 G-X-G motif; other site 247156009789 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 247156009790 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 247156009791 active site 247156009792 phosphorylation site [posttranslational modification] 247156009793 intermolecular recognition site; other site 247156009794 dimerization interface [polypeptide binding]; other site 247156009795 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 247156009796 DNA binding residues [nucleotide binding] 247156009797 dimerization interface [polypeptide binding]; other site 247156009798 Transcriptional regulator [Transcription]; Region: LysR; COG0583 247156009799 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 247156009800 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 247156009801 putative substrate binding pocket [chemical binding]; other site 247156009802 putative dimerization interface [polypeptide binding]; other site 247156009803 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156009804 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156009805 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 247156009806 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 247156009807 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 247156009808 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 247156009809 Coenzyme A binding pocket [chemical binding]; other site 247156009810 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 247156009811 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 247156009812 Walker A motif; other site 247156009813 ATP binding site [chemical binding]; other site 247156009814 Walker B motif; other site 247156009815 hypothetical protein; Provisional; Region: PRK14059 247156009816 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 247156009817 TAP-like protein; Region: Abhydrolase_4; pfam08386 247156009818 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 247156009819 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 247156009820 SelR domain; Region: SelR; pfam01641 247156009821 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 247156009822 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 247156009823 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 247156009824 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 247156009825 substrate binding site [chemical binding]; other site 247156009826 active site 247156009827 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 247156009828 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 247156009829 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 247156009830 catalytic site [active] 247156009831 putative active site [active] 247156009832 putative substrate binding site [chemical binding]; other site 247156009833 Helicase and RNase D C-terminal; Region: HRDC; smart00341 247156009834 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 247156009835 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 247156009836 TPP-binding site; other site 247156009837 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 247156009838 PYR/PP interface [polypeptide binding]; other site 247156009839 dimer interface [polypeptide binding]; other site 247156009840 TPP binding site [chemical binding]; other site 247156009841 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 247156009842 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 247156009843 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 247156009844 TRAM domain; Region: TRAM; pfam01938 247156009845 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 247156009846 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 247156009847 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 247156009848 TrkA-N domain; Region: TrkA_N; pfam02254 247156009849 TrkA-C domain; Region: TrkA_C; pfam02080 247156009850 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 247156009851 TrkA-N domain; Region: TrkA_N; pfam02254 247156009852 TrkA-C domain; Region: TrkA_C; pfam02080 247156009853 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 247156009854 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 247156009855 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 247156009856 DNA binding residues [nucleotide binding] 247156009857 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 247156009858 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 247156009859 generic binding surface II; other site 247156009860 ssDNA binding site; other site 247156009861 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 247156009862 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 247156009863 trimer interface [polypeptide binding]; other site 247156009864 active site 247156009865 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 247156009866 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 247156009867 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 247156009868 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 247156009869 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 247156009870 active site 247156009871 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 247156009872 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 247156009873 nucleotide binding site [chemical binding]; other site 247156009874 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 247156009875 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 247156009876 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 247156009877 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 247156009878 DNA binding residues [nucleotide binding] 247156009879 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 247156009880 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 247156009881 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 247156009882 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 247156009883 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 247156009884 TrkA-C domain; Region: TrkA_C; pfam02080 247156009885 Protein of unknown function (DUF952); Region: DUF952; pfam06108 247156009886 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156009887 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156009888 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 247156009889 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 247156009890 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 247156009891 ATP binding site [chemical binding]; other site 247156009892 putative Mg++ binding site [ion binding]; other site 247156009893 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 247156009894 nucleotide binding region [chemical binding]; other site 247156009895 ATP-binding site [chemical binding]; other site 247156009896 Uncharacterized conserved protein [Function unknown]; Region: COG4279 247156009897 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156009898 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 247156009899 NAD(P) binding site [chemical binding]; other site 247156009900 active site 247156009901 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156009902 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156009903 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 247156009904 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 247156009905 ATP binding site [chemical binding]; other site 247156009906 putative Mg++ binding site [ion binding]; other site 247156009907 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 247156009908 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 247156009909 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 247156009910 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 247156009911 active site 247156009912 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156009913 S-adenosylmethionine binding site [chemical binding]; other site 247156009914 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 247156009915 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 247156009916 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 247156009917 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 247156009918 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 247156009919 DNA binding residues [nucleotide binding] 247156009920 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 247156009921 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 247156009922 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 247156009923 Coenzyme A binding pocket [chemical binding]; other site 247156009924 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 247156009925 CoA binding domain; Region: CoA_binding_2; pfam13380 247156009926 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 247156009927 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 247156009928 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 247156009929 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 247156009930 active site 247156009931 Zn binding site [ion binding]; other site 247156009932 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 247156009933 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 247156009934 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 247156009935 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 247156009936 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 247156009937 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 247156009938 NAD binding site [chemical binding]; other site 247156009939 homodimer interface [polypeptide binding]; other site 247156009940 active site 247156009941 substrate binding site [chemical binding]; other site 247156009942 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 247156009943 PAC2 family; Region: PAC2; pfam09754 247156009944 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 247156009945 ATP binding site [chemical binding]; other site 247156009946 putative Mg++ binding site [ion binding]; other site 247156009947 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 247156009948 nucleotide binding region [chemical binding]; other site 247156009949 ATP-binding site [chemical binding]; other site 247156009950 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 247156009951 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 247156009952 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 247156009953 dimer interface [polypeptide binding]; other site 247156009954 active site 247156009955 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 247156009956 catalytic residues [active] 247156009957 substrate binding site [chemical binding]; other site 247156009958 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 247156009959 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156009960 S-adenosylmethionine binding site [chemical binding]; other site 247156009961 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 247156009962 putative active site pocket [active] 247156009963 dimerization interface [polypeptide binding]; other site 247156009964 putative catalytic residue [active] 247156009965 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 247156009966 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 247156009967 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 247156009968 dimerization interface [polypeptide binding]; other site 247156009969 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 247156009970 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 247156009971 dimer interface [polypeptide binding]; other site 247156009972 decamer (pentamer of dimers) interface [polypeptide binding]; other site 247156009973 catalytic triad [active] 247156009974 peroxidatic and resolving cysteines [active] 247156009975 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 247156009976 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 247156009977 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 247156009978 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 247156009979 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 247156009980 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156009981 NAD(P) binding site [chemical binding]; other site 247156009982 active site 247156009983 acyl-CoA synthetase; Validated; Region: PRK07788 247156009984 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 247156009985 acyl-activating enzyme (AAE) consensus motif; other site 247156009986 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 247156009987 AMP binding site [chemical binding]; other site 247156009988 active site 247156009989 acyl-activating enzyme (AAE) consensus motif; other site 247156009990 CoA binding site [chemical binding]; other site 247156009991 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 247156009992 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 247156009993 inhibitor-cofactor binding pocket; inhibition site 247156009994 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156009995 catalytic residue [active] 247156009996 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 247156009997 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 247156009998 ATP binding site [chemical binding]; other site 247156009999 putative Mg++ binding site [ion binding]; other site 247156010000 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 247156010001 nucleotide binding region [chemical binding]; other site 247156010002 ATP-binding site [chemical binding]; other site 247156010003 Helicase associated domain (HA2); Region: HA2; pfam04408 247156010004 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 247156010005 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 247156010006 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 247156010007 ATP cone domain; Region: ATP-cone; pfam03477 247156010008 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 247156010009 LexA repressor; Validated; Region: PRK00215 247156010010 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 247156010011 Catalytic site [active] 247156010012 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 247156010013 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 247156010014 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 247156010015 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 247156010016 DNA binding residues [nucleotide binding] 247156010017 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 247156010018 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 247156010019 putative ADP-binding pocket [chemical binding]; other site 247156010020 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 247156010021 Predicted transcriptional regulators [Transcription]; Region: COG1733 247156010022 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 247156010023 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 247156010024 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 247156010025 YrhK-like protein; Region: YrhK; pfam14145 247156010026 Transcriptional regulators [Transcription]; Region: MarR; COG1846 247156010027 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 247156010028 putative DNA binding site [nucleotide binding]; other site 247156010029 putative Zn2+ binding site [ion binding]; other site 247156010030 Domain of unknown function (DUF305); Region: DUF305; pfam03713 247156010031 WYL domain; Region: WYL; pfam13280 247156010032 DinB superfamily; Region: DinB_2; pfam12867 247156010033 Uncharacterized conserved protein [Function unknown]; Region: COG1434 247156010034 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 247156010035 putative active site [active] 247156010036 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 247156010037 ABC1 family; Region: ABC1; pfam03109 247156010038 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 247156010039 active site 247156010040 ATP binding site [chemical binding]; other site 247156010041 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156010042 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 247156010043 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156010044 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156010045 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 247156010046 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 247156010047 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 247156010048 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 247156010049 CGNR zinc finger; Region: zf-CGNR; pfam11706 247156010050 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 247156010051 sequence-specific DNA binding site [nucleotide binding]; other site 247156010052 salt bridge; other site 247156010053 Escherichia coli YaeB and related proteins; Region: UPF0066; cl00749 247156010054 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156010055 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156010056 active site 247156010057 Putative esterase; Region: Esterase; pfam00756 247156010058 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 247156010059 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 247156010060 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 247156010061 putative acyl-acceptor binding pocket; other site 247156010062 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 247156010063 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 247156010064 HflX GTPase family; Region: HflX; cd01878 247156010065 G1 box; other site 247156010066 GTP/Mg2+ binding site [chemical binding]; other site 247156010067 Switch I region; other site 247156010068 G2 box; other site 247156010069 G3 box; other site 247156010070 Switch II region; other site 247156010071 G4 box; other site 247156010072 G5 box; other site 247156010073 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 247156010074 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 247156010075 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 247156010076 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 247156010077 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 247156010078 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 247156010079 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 247156010080 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 247156010081 active site 247156010082 metal binding site [ion binding]; metal-binding site 247156010083 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 247156010084 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 247156010085 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 247156010086 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 247156010087 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 247156010088 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 247156010089 FeS/SAM binding site; other site 247156010090 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 247156010091 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 247156010092 Walker A/P-loop; other site 247156010093 ATP binding site [chemical binding]; other site 247156010094 Q-loop/lid; other site 247156010095 ABC transporter signature motif; other site 247156010096 Walker B; other site 247156010097 D-loop; other site 247156010098 H-loop/switch region; other site 247156010099 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 247156010100 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 247156010101 substrate binding pocket [chemical binding]; other site 247156010102 membrane-bound complex binding site; other site 247156010103 hinge residues; other site 247156010104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 247156010105 dimer interface [polypeptide binding]; other site 247156010106 conserved gate region; other site 247156010107 ABC-ATPase subunit interface; other site 247156010108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 247156010109 dimer interface [polypeptide binding]; other site 247156010110 conserved gate region; other site 247156010111 putative PBP binding loops; other site 247156010112 ABC-ATPase subunit interface; other site 247156010113 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 247156010114 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 247156010115 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 247156010116 recombination regulator RecX; Reviewed; Region: recX; PRK00117 247156010117 recombinase A; Provisional; Region: recA; PRK09354 247156010118 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 247156010119 hexamer interface [polypeptide binding]; other site 247156010120 Walker A motif; other site 247156010121 ATP binding site [chemical binding]; other site 247156010122 Walker B motif; other site 247156010123 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 247156010124 SnoaL-like domain; Region: SnoaL_2; pfam12680 247156010125 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 247156010126 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 247156010127 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 247156010128 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 247156010129 putative dimer interface [polypeptide binding]; other site 247156010130 ligand binding site [chemical binding]; other site 247156010131 Zn binding site [ion binding]; other site 247156010132 CGNR zinc finger; Region: zf-CGNR; pfam11706 247156010133 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 247156010134 active site 247156010135 ATP binding site [chemical binding]; other site 247156010136 Phosphotransferase enzyme family; Region: APH; pfam01636 247156010137 antibiotic binding site [chemical binding]; other site 247156010138 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 247156010139 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 247156010140 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 247156010141 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 247156010142 active site 247156010143 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 247156010144 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 247156010145 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156010146 non-specific DNA binding site [nucleotide binding]; other site 247156010147 salt bridge; other site 247156010148 sequence-specific DNA binding site [nucleotide binding]; other site 247156010149 Competence-damaged protein; Region: CinA; pfam02464 247156010150 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 247156010151 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 247156010152 Coenzyme A binding pocket [chemical binding]; other site 247156010153 YCII-related domain; Region: YCII; cl00999 247156010154 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 247156010155 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 247156010156 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 247156010157 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 247156010158 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 247156010159 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 247156010160 TIGR03085 family protein; Region: TIGR03085 247156010161 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 247156010162 YtkA-like; Region: YtkA; pfam13115 247156010163 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 247156010164 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 247156010165 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 247156010166 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 247156010167 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 247156010168 dimer interface [polypeptide binding]; other site 247156010169 active site 247156010170 catalytic residue [active] 247156010171 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 247156010172 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 247156010173 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 247156010174 ATP binding site [chemical binding]; other site 247156010175 Mg2+ binding site [ion binding]; other site 247156010176 G-X-G motif; other site 247156010177 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 247156010178 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 247156010179 active site 247156010180 phosphorylation site [posttranslational modification] 247156010181 intermolecular recognition site; other site 247156010182 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 247156010183 DNA binding residues [nucleotide binding] 247156010184 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156010185 sequence-specific DNA binding site [nucleotide binding]; other site 247156010186 salt bridge; other site 247156010187 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 247156010188 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 247156010189 dihydrodipicolinate reductase; Provisional; Region: PRK00048 247156010190 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 247156010191 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 247156010192 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 247156010193 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 247156010194 NAD(P) binding site [chemical binding]; other site 247156010195 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156010196 Major Facilitator Superfamily; Region: MFS_1; pfam07690 247156010197 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 247156010198 putative DNA binding site [nucleotide binding]; other site 247156010199 putative Zn2+ binding site [ion binding]; other site 247156010200 helix_turn_helix, Arsenical Resistance Operon Repressor; Region: HTH_ARSR; smart00418 247156010201 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 247156010202 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 247156010203 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 247156010204 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 247156010205 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 247156010206 oligomer interface [polypeptide binding]; other site 247156010207 RNA binding site [nucleotide binding]; other site 247156010208 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 247156010209 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 247156010210 RNase E interface [polypeptide binding]; other site 247156010211 trimer interface [polypeptide binding]; other site 247156010212 active site 247156010213 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 247156010214 putative nucleic acid binding region [nucleotide binding]; other site 247156010215 G-X-X-G motif; other site 247156010216 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 247156010217 RNA binding site [nucleotide binding]; other site 247156010218 domain interface; other site 247156010219 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 247156010220 16S/18S rRNA binding site [nucleotide binding]; other site 247156010221 S13e-L30e interaction site [polypeptide binding]; other site 247156010222 25S rRNA binding site [nucleotide binding]; other site 247156010223 SnoaL-like domain; Region: SnoaL_2; pfam12680 247156010224 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 247156010225 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 247156010226 active site 247156010227 Riboflavin kinase; Region: Flavokinase; smart00904 247156010228 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 247156010229 active site 247156010230 catalytic residues [active] 247156010231 DNA binding site [nucleotide binding] 247156010232 Int/Topo IB signature motif; other site 247156010233 Helix-turn-helix domain; Region: HTH_17; pfam12728 247156010234 MarR family; Region: MarR_2; cl17246 247156010235 conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729 247156010236 N-acetylmuramoyl-L-alanine amidase; Region: Amidase_2; pfam01510 247156010237 substrate binding site [chemical binding]; other site 247156010238 LGFP repeat; Region: LGFP; pfam08310 247156010239 LGFP repeat; Region: LGFP; pfam08310 247156010240 Protein of unknown function (DUF2744); Region: DUF2744; pfam10910 247156010241 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 247156010242 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 247156010243 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 247156010244 N-acetyl-D-glucosamine binding site [chemical binding]; other site 247156010245 catalytic residue [active] 247156010246 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 247156010247 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 247156010248 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 247156010249 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 247156010250 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 247156010251 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 247156010252 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 247156010253 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 247156010254 phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542 247156010255 Phage terminase large subunit; Region: Terminase_3; cl12054 247156010256 Terminase-like family; Region: Terminase_6; pfam03237 247156010257 Helix-turn-helix domain; Region: HTH_38; pfam13936 247156010258 hypothetical protein; Region: PHA02451 247156010259 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 247156010260 catalytic residues [active] 247156010261 PE-PPE domain; Region: PE-PPE; pfam08237 247156010262 tRNAHis guanylyltransferase; Region: Thg1; pfam04446 247156010263 Thg1 C terminal domain; Region: Thg1C; pfam14413 247156010264 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156010265 S-adenosylmethionine binding site [chemical binding]; other site 247156010266 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530 247156010267 metal binding site [ion binding]; metal-binding site 247156010268 Phosphoribosyl-ATP pyrophosphohydrolase; Region: PRA-PH; pfam01503 247156010269 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 247156010270 Phage protein Gp37/Gp68; Region: Gp37_Gp68; pfam07505 247156010271 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 247156010272 polynucleotide kinase; Provisional; Region: pseT; PHA02530 247156010273 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 247156010274 RNA ligase, DRB0094 family; Region: RNA_lig_DRB0094; TIGR02306 247156010275 RNA ligase; Region: RNA_ligase; pfam09414 247156010276 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 247156010277 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 247156010278 active site 247156010279 metal binding site [ion binding]; metal-binding site 247156010280 TROVE domain; Region: TROVE; pfam05731 247156010281 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 247156010282 DNA polymerase III subunit beta; Validated; Region: PRK07761 247156010283 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 247156010284 putative DNA binding surface [nucleotide binding]; other site 247156010285 dimer interface [polypeptide binding]; other site 247156010286 beta-clamp/clamp loader binding surface; other site 247156010287 beta-clamp/translesion DNA polymerase binding surface; other site 247156010288 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 247156010289 Endodeoxyribonuclease RusA; Region: RusA; cl01885 247156010290 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 247156010291 RNA/DNA hybrid binding site [nucleotide binding]; other site 247156010292 active site 247156010293 Domain of unknown function (DUF4326); Region: DUF4326; pfam14216 247156010294 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 247156010295 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 247156010296 Putative peptidase family; Region: Metallopep; pfam12044 247156010297 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 247156010298 DNA methylase; Region: N6_N4_Mtase; pfam01555 247156010299 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442 247156010300 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 247156010301 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 247156010302 cofactor binding site; other site 247156010303 DNA binding site [nucleotide binding] 247156010304 substrate interaction site [chemical binding]; other site 247156010305 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 247156010306 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 247156010307 active site 247156010308 catalytic site [active] 247156010309 substrate binding site [chemical binding]; other site 247156010310 recombination and repair protein RecT; Reviewed; Region: recT; PRK09846 247156010311 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 247156010312 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156010313 non-specific DNA binding site [nucleotide binding]; other site 247156010314 salt bridge; other site 247156010315 sequence-specific DNA binding site [nucleotide binding]; other site 247156010316 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 247156010317 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 247156010318 putative DNA binding site [nucleotide binding]; other site 247156010319 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 247156010320 FeoA domain; Region: FeoA; pfam04023 247156010321 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 247156010322 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 247156010323 RNA binding site [nucleotide binding]; other site 247156010324 active site 247156010325 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 247156010326 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 247156010327 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 247156010328 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 247156010329 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 247156010330 active site 247156010331 metal binding site [ion binding]; metal-binding site 247156010332 Tissue factor; Region: Tissue_fac; pfam01108 247156010333 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 247156010334 Actin-like ATPase involved in cell morphogenesis [Cell division and chromosome partitioning]; Region: MreB; COG1077 247156010335 nucleotide binding site [chemical binding]; other site 247156010336 putative NEF/HSP70 interaction site [polypeptide binding]; other site 247156010337 SBD interface [polypeptide binding]; other site 247156010338 TIGR03943 family protein; Region: TIGR03943 247156010339 Predicted permease; Region: DUF318; cl17795 247156010340 Cupin-like domain; Region: Cupin_8; pfam13621 247156010341 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 247156010342 active site 247156010343 NTP binding site [chemical binding]; other site 247156010344 metal binding triad [ion binding]; metal-binding site 247156010345 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 247156010346 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 247156010347 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 247156010348 DHH family; Region: DHH; pfam01368 247156010349 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 247156010350 Protein of unknown function (DUF503); Region: DUF503; pfam04456 247156010351 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 247156010352 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 247156010353 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 247156010354 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 247156010355 G1 box; other site 247156010356 putative GEF interaction site [polypeptide binding]; other site 247156010357 GTP/Mg2+ binding site [chemical binding]; other site 247156010358 Switch I region; other site 247156010359 G2 box; other site 247156010360 G3 box; other site 247156010361 Switch II region; other site 247156010362 G4 box; other site 247156010363 G5 box; other site 247156010364 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 247156010365 Translation-initiation factor 2; Region: IF-2; pfam11987 247156010366 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 247156010367 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 247156010368 putative RNA binding cleft [nucleotide binding]; other site 247156010369 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 247156010370 NusA N-terminal domain; Region: NusA_N; pfam08529 247156010371 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 247156010372 RNA binding site [nucleotide binding]; other site 247156010373 homodimer interface [polypeptide binding]; other site 247156010374 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 247156010375 G-X-X-G motif; other site 247156010376 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 247156010377 G-X-X-G motif; other site 247156010378 ribosome maturation protein RimP; Reviewed; Region: PRK00092 247156010379 Sm and related proteins; Region: Sm_like; cl00259 247156010380 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 247156010381 putative oligomer interface [polypeptide binding]; other site 247156010382 putative RNA binding site [nucleotide binding]; other site 247156010383 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 247156010384 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156010385 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156010386 active site 247156010387 prolyl-tRNA synthetase; Provisional; Region: PRK09194 247156010388 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 247156010389 dimer interface [polypeptide binding]; other site 247156010390 motif 1; other site 247156010391 active site 247156010392 motif 2; other site 247156010393 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 247156010394 putative deacylase active site [active] 247156010395 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 247156010396 active site 247156010397 motif 3; other site 247156010398 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 247156010399 anticodon binding site; other site 247156010400 hypothetical protein; Validated; Region: PRK02101 247156010401 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 247156010402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156010403 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 247156010404 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 247156010405 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 247156010406 active site 247156010407 SAM binding site [chemical binding]; other site 247156010408 homodimer interface [polypeptide binding]; other site 247156010409 Phosphotransferase enzyme family; Region: APH; pfam01636 247156010410 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 247156010411 putative active site [active] 247156010412 putative substrate binding site [chemical binding]; other site 247156010413 ATP binding site [chemical binding]; other site 247156010414 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 247156010415 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 247156010416 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 247156010417 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 247156010418 catalytic triad [active] 247156010419 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 247156010420 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 247156010421 Walker A motif; other site 247156010422 homodimer interface [polypeptide binding]; other site 247156010423 ATP binding site [chemical binding]; other site 247156010424 hydroxycobalamin binding site [chemical binding]; other site 247156010425 Walker B motif; other site 247156010426 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 247156010427 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 247156010428 Walker A motif; other site 247156010429 ATP binding site [chemical binding]; other site 247156010430 Walker B motif; other site 247156010431 arginine finger; other site 247156010432 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 247156010433 metal ion-dependent adhesion site (MIDAS); other site 247156010434 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 247156010435 Coenzyme A binding pocket [chemical binding]; other site 247156010436 malate:quinone oxidoreductase; Validated; Region: PRK05257 247156010437 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 247156010438 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 247156010439 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 247156010440 cobyric acid synthase; Provisional; Region: PRK00784 247156010441 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 247156010442 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 247156010443 catalytic triad [active] 247156010444 methionine aminopeptidase; Provisional; Region: PRK12318 247156010445 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 247156010446 active site 247156010447 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 247156010448 classical (c) SDRs; Region: SDR_c; cd05233 247156010449 NAD(P) binding site [chemical binding]; other site 247156010450 active site 247156010451 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12845 247156010452 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 247156010453 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 247156010454 Domain of unknown function (DUF718); Region: DUF718; cl01281 247156010455 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 247156010456 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 247156010457 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 247156010458 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 247156010459 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 247156010460 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 247156010461 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 247156010462 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 247156010463 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 247156010464 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 247156010465 active site 247156010466 Fe binding site [ion binding]; other site 247156010467 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 247156010468 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 247156010469 FAD binding pocket [chemical binding]; other site 247156010470 FAD binding motif [chemical binding]; other site 247156010471 phosphate binding motif [ion binding]; other site 247156010472 beta-alpha-beta structure motif; other site 247156010473 NAD(p) ribose binding residues [chemical binding]; other site 247156010474 NAD binding pocket [chemical binding]; other site 247156010475 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 247156010476 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 247156010477 catalytic loop [active] 247156010478 iron binding site [ion binding]; other site 247156010479 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 247156010480 putative homotetramer interface [polypeptide binding]; other site 247156010481 putative homodimer interface [polypeptide binding]; other site 247156010482 putative allosteric switch controlling residues; other site 247156010483 putative metal binding site [ion binding]; other site 247156010484 putative homodimer-homodimer interface [polypeptide binding]; other site 247156010485 Domain of unknown function DUF302; Region: DUF302; pfam03625 247156010486 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 247156010487 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 247156010488 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 247156010489 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 247156010490 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 247156010491 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 247156010492 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 247156010493 NAD binding site [chemical binding]; other site 247156010494 catalytic Zn binding site [ion binding]; other site 247156010495 structural Zn binding site [ion binding]; other site 247156010496 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 247156010497 hydrophobic ligand binding site; other site 247156010498 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156010499 salt bridge; other site 247156010500 non-specific DNA binding site [nucleotide binding]; other site 247156010501 sequence-specific DNA binding site [nucleotide binding]; other site 247156010502 ABC-2 type transporter; Region: ABC2_membrane; cl17235 247156010503 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 247156010504 heme-binding site [chemical binding]; other site 247156010505 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 247156010506 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 247156010507 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 247156010508 Predicted acetyltransferase [General function prediction only]; Region: COG3393 247156010509 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 247156010510 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 247156010511 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 247156010512 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 247156010513 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 247156010514 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 247156010515 active site 247156010516 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 247156010517 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 247156010518 putative substrate binding region [chemical binding]; other site 247156010519 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 247156010520 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 247156010521 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 247156010522 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 247156010523 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 247156010524 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 247156010525 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 247156010526 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 247156010527 dimerization interface [polypeptide binding]; other site 247156010528 Possible enoyl reductase; Region: MDR_enoyl_red; cd08244 247156010529 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 247156010530 putative NAD(P) binding site [chemical binding]; other site 247156010531 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 247156010532 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 247156010533 FeS/SAM binding site; other site 247156010534 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 247156010535 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 247156010536 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 247156010537 ribosome recycling factor; Reviewed; Region: frr; PRK00083 247156010538 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 247156010539 hinge region; other site 247156010540 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 247156010541 putative nucleotide binding site [chemical binding]; other site 247156010542 uridine monophosphate binding site [chemical binding]; other site 247156010543 homohexameric interface [polypeptide binding]; other site 247156010544 elongation factor Ts; Provisional; Region: tsf; PRK09377 247156010545 UBA/TS-N domain; Region: UBA; pfam00627 247156010546 Elongation factor TS; Region: EF_TS; pfam00889 247156010547 Elongation factor TS; Region: EF_TS; pfam00889 247156010548 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 247156010549 rRNA interaction site [nucleotide binding]; other site 247156010550 S8 interaction site; other site 247156010551 putative laminin-1 binding site; other site 247156010552 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 247156010553 Peptidase family M23; Region: Peptidase_M23; pfam01551 247156010554 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 247156010555 GAF domain; Region: GAF_3; pfam13492 247156010556 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 247156010557 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 247156010558 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 247156010559 Domain of unknown function (DUF202); Region: DUF202; cl09954 247156010560 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 247156010561 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 247156010562 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 247156010563 active site 247156010564 DNA binding site [nucleotide binding] 247156010565 Int/Topo IB signature motif; other site 247156010566 DNA protecting protein DprA; Region: dprA; TIGR00732 247156010567 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 247156010568 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 247156010569 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 247156010570 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 247156010571 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 247156010572 hypothetical protein; Reviewed; Region: PRK12497 247156010573 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 247156010574 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 247156010575 RNA/DNA hybrid binding site [nucleotide binding]; other site 247156010576 active site 247156010577 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 247156010578 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 247156010579 Catalytic site [active] 247156010580 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 247156010581 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 247156010582 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 247156010583 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 247156010584 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 247156010585 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 247156010586 RNA binding site [nucleotide binding]; other site 247156010587 AMP-binding domain protein; Validated; Region: PRK08315 247156010588 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 247156010589 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 247156010590 acyl-activating enzyme (AAE) consensus motif; other site 247156010591 putative AMP binding site [chemical binding]; other site 247156010592 putative active site [active] 247156010593 putative CoA binding site [chemical binding]; other site 247156010594 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 247156010595 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 247156010596 acyl-activating enzyme (AAE) consensus motif; other site 247156010597 AMP binding site [chemical binding]; other site 247156010598 active site 247156010599 CoA binding site [chemical binding]; other site 247156010600 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 247156010601 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 247156010602 DNA binding residues [nucleotide binding] 247156010603 dimerization interface [polypeptide binding]; other site 247156010604 PQQ-like domain; Region: PQQ_2; pfam13360 247156010605 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 247156010606 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 247156010607 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 247156010608 RimM N-terminal domain; Region: RimM; pfam01782 247156010609 PRC-barrel domain; Region: PRC; pfam05239 247156010610 hypothetical protein; Provisional; Region: PRK02821 247156010611 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 247156010612 G-X-X-G motif; other site 247156010613 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 247156010614 RibD C-terminal domain; Region: RibD_C; cl17279 247156010615 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 247156010616 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 247156010617 Amidohydrolase; Region: Amidohydro_4; pfam13147 247156010618 active site 247156010619 signal recognition particle protein; Provisional; Region: PRK10867 247156010620 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 247156010621 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 247156010622 P loop; other site 247156010623 GTP binding site [chemical binding]; other site 247156010624 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 247156010625 Signal peptide binding domain; Region: SRP_SPB; pfam02978 247156010626 PII uridylyl-transferase; Provisional; Region: PRK03381 247156010627 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 247156010628 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 247156010629 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 247156010630 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 247156010631 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 247156010632 Nitrogen regulatory protein P-II; Region: P-II; smart00938 247156010633 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 247156010634 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 247156010635 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 247156010636 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 247156010637 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 247156010638 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 247156010639 AAA domain; Region: AAA_23; pfam13476 247156010640 Walker A/P-loop; other site 247156010641 ATP binding site [chemical binding]; other site 247156010642 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 247156010643 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 247156010644 ABC transporter signature motif; other site 247156010645 Walker B; other site 247156010646 D-loop; other site 247156010647 H-loop/switch region; other site 247156010648 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 247156010649 2TM domain; Region: 2TM; pfam13239 247156010650 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 247156010651 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 247156010652 Acylphosphatase; Region: Acylphosphatase; cl00551 247156010653 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 247156010654 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 247156010655 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 247156010656 putative ADP-binding pocket [chemical binding]; other site 247156010657 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 247156010658 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 247156010659 PBP superfamily domain; Region: PBP_like_2; cl17296 247156010660 hypothetical protein; Provisional; Region: PRK07945 247156010661 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 247156010662 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 247156010663 active site 247156010664 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 247156010665 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 247156010666 NADP+ binding site [chemical binding]; other site 247156010667 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 247156010668 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 247156010669 DNA binding site [nucleotide binding] 247156010670 catalytic residue [active] 247156010671 H2TH interface [polypeptide binding]; other site 247156010672 putative catalytic residues [active] 247156010673 turnover-facilitating residue; other site 247156010674 intercalation triad [nucleotide binding]; other site 247156010675 8OG recognition residue [nucleotide binding]; other site 247156010676 putative reading head residues; other site 247156010677 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 247156010678 ribonuclease III; Reviewed; Region: rnc; PRK00102 247156010679 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 247156010680 dimerization interface [polypeptide binding]; other site 247156010681 active site 247156010682 metal binding site [ion binding]; metal-binding site 247156010683 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 247156010684 dsRNA binding site [nucleotide binding]; other site 247156010685 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 247156010686 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 247156010687 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 247156010688 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 247156010689 GtrA-like protein; Region: GtrA; pfam04138 247156010690 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 247156010691 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 247156010692 active site 247156010693 (T/H)XGH motif; other site 247156010694 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 247156010695 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 247156010696 pyruvate carboxylase; Reviewed; Region: PRK12999 247156010697 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 247156010698 ATP-grasp domain; Region: ATP-grasp_4; cl17255 247156010699 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 247156010700 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 247156010701 active site 247156010702 catalytic residues [active] 247156010703 metal binding site [ion binding]; metal-binding site 247156010704 homodimer binding site [polypeptide binding]; other site 247156010705 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 247156010706 carboxyltransferase (CT) interaction site; other site 247156010707 biotinylation site [posttranslational modification]; other site 247156010708 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 247156010709 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 247156010710 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156010711 sequence-specific DNA binding site [nucleotide binding]; other site 247156010712 salt bridge; other site 247156010713 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 247156010714 Domain of unknown function (DUF955); Region: DUF955; pfam06114 247156010715 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 247156010716 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 247156010717 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 247156010718 generic binding surface II; other site 247156010719 ssDNA binding site; other site 247156010720 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 247156010721 ATP binding site [chemical binding]; other site 247156010722 putative Mg++ binding site [ion binding]; other site 247156010723 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 247156010724 nucleotide binding region [chemical binding]; other site 247156010725 ATP-binding site [chemical binding]; other site 247156010726 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 247156010727 DAK2 domain; Region: Dak2; pfam02734 247156010728 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 247156010729 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 247156010730 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 247156010731 enoyl-CoA hydratase; Provisional; Region: PRK06688 247156010732 substrate binding site [chemical binding]; other site 247156010733 oxyanion hole (OAH) forming residues; other site 247156010734 trimer interface [polypeptide binding]; other site 247156010735 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 247156010736 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 247156010737 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 247156010738 ligand binding site [chemical binding]; other site 247156010739 active site 247156010740 UGI interface [polypeptide binding]; other site 247156010741 catalytic site [active] 247156010742 thiamine monophosphate kinase; Provisional; Region: PRK05731 247156010743 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 247156010744 ATP binding site [chemical binding]; other site 247156010745 dimerization interface [polypeptide binding]; other site 247156010746 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 247156010747 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156010748 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156010749 hypothetical protein; Provisional; Region: PRK07233 247156010750 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 247156010751 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 247156010752 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 247156010753 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 247156010754 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 247156010755 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 247156010756 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 247156010757 polyphosphate kinase; Provisional; Region: PRK05443 247156010758 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 247156010759 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 247156010760 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 247156010761 putative domain interface [polypeptide binding]; other site 247156010762 putative active site [active] 247156010763 catalytic site [active] 247156010764 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 247156010765 putative domain interface [polypeptide binding]; other site 247156010766 putative active site [active] 247156010767 catalytic site [active] 247156010768 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 247156010769 active site 247156010770 Ap6A binding site [chemical binding]; other site 247156010771 nudix motif; other site 247156010772 metal binding site [ion binding]; metal-binding site 247156010773 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 247156010774 catalytic core [active] 247156010775 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 247156010776 IHF - DNA interface [nucleotide binding]; other site 247156010777 IHF dimer interface [polypeptide binding]; other site 247156010778 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 247156010779 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 247156010780 substrate binding site [chemical binding]; other site 247156010781 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 247156010782 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 247156010783 substrate binding site [chemical binding]; other site 247156010784 ligand binding site [chemical binding]; other site 247156010785 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 247156010786 Transcriptional regulator [Transcription]; Region: IclR; COG1414 247156010787 Bacterial transcriptional regulator; Region: IclR; pfam01614 247156010788 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 247156010789 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 247156010790 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 247156010791 HIGH motif; other site 247156010792 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 247156010793 active site 247156010794 KMSKS motif; other site 247156010795 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 247156010796 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 247156010797 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 247156010798 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156010799 Major Facilitator Superfamily; Region: MFS_1; pfam07690 247156010800 putative substrate translocation pore; other site 247156010801 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 247156010802 putative active site [active] 247156010803 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 247156010804 tartrate dehydrogenase; Region: TTC; TIGR02089 247156010805 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 247156010806 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 247156010807 ligand binding site [chemical binding]; other site 247156010808 NAD binding site [chemical binding]; other site 247156010809 dimerization interface [polypeptide binding]; other site 247156010810 catalytic site [active] 247156010811 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 247156010812 putative L-serine binding site [chemical binding]; other site 247156010813 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 247156010814 DNA-binding site [nucleotide binding]; DNA binding site 247156010815 RNA-binding motif; other site 247156010816 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 247156010817 DNA-binding site [nucleotide binding]; DNA binding site 247156010818 RNA-binding motif; other site 247156010819 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 247156010820 active site 247156010821 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 247156010822 putative active site [active] 247156010823 ketol-acid reductoisomerase; Provisional; Region: PRK05479 247156010824 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 247156010825 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 247156010826 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 247156010827 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 247156010828 putative valine binding site [chemical binding]; other site 247156010829 dimer interface [polypeptide binding]; other site 247156010830 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 247156010831 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 247156010832 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 247156010833 PYR/PP interface [polypeptide binding]; other site 247156010834 dimer interface [polypeptide binding]; other site 247156010835 TPP binding site [chemical binding]; other site 247156010836 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 247156010837 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 247156010838 TPP-binding site [chemical binding]; other site 247156010839 dimer interface [polypeptide binding]; other site 247156010840 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 247156010841 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 247156010842 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 247156010843 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 247156010844 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 247156010845 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 247156010846 GatB domain; Region: GatB_Yqey; smart00845 247156010847 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 247156010848 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 247156010849 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 247156010850 6-phosphofructokinase; Provisional; Region: PRK03202 247156010851 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 247156010852 active site 247156010853 ADP/pyrophosphate binding site [chemical binding]; other site 247156010854 dimerization interface [polypeptide binding]; other site 247156010855 allosteric effector site; other site 247156010856 fructose-1,6-bisphosphate binding site; other site 247156010857 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 247156010858 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 247156010859 active site 247156010860 FMN binding site [chemical binding]; other site 247156010861 substrate binding site [chemical binding]; other site 247156010862 putative catalytic residue [active] 247156010863 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156010864 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 247156010865 Catalytic domain of Protein Kinases; Region: PKc; cd00180 247156010866 active site 247156010867 ATP binding site [chemical binding]; other site 247156010868 substrate binding site [chemical binding]; other site 247156010869 activation loop (A-loop); other site 247156010870 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 247156010871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 247156010872 active site 247156010873 phosphorylation site [posttranslational modification] 247156010874 intermolecular recognition site; other site 247156010875 dimerization interface [polypeptide binding]; other site 247156010876 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 247156010877 DNA binding residues [nucleotide binding] 247156010878 dimerization interface [polypeptide binding]; other site 247156010879 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 247156010880 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 247156010881 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 247156010882 Walker A/P-loop; other site 247156010883 ATP binding site [chemical binding]; other site 247156010884 Q-loop/lid; other site 247156010885 ABC transporter signature motif; other site 247156010886 Walker B; other site 247156010887 D-loop; other site 247156010888 H-loop/switch region; other site 247156010889 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 247156010890 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 247156010891 Catalytic domain of Protein Kinases; Region: PKc; cd00180 247156010892 active site 247156010893 ATP binding site [chemical binding]; other site 247156010894 substrate binding site [chemical binding]; other site 247156010895 activation loop (A-loop); other site 247156010896 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 247156010897 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 247156010898 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 247156010899 active site 247156010900 phosphorylation site [posttranslational modification] 247156010901 intermolecular recognition site; other site 247156010902 dimerization interface [polypeptide binding]; other site 247156010903 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 247156010904 DNA binding residues [nucleotide binding] 247156010905 dimerization interface [polypeptide binding]; other site 247156010906 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 247156010907 Histidine kinase; Region: HisKA_3; pfam07730 247156010908 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 247156010909 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 247156010910 putative hydrophobic ligand binding site [chemical binding]; other site 247156010911 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 247156010912 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 247156010913 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 247156010914 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 247156010915 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 247156010916 Coenzyme A binding pocket [chemical binding]; other site 247156010917 AAA domain; Region: AAA_21; pfam13304 247156010918 AAA domain; Region: AAA_21; pfam13304 247156010919 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 247156010920 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 247156010921 nucleotide binding pocket [chemical binding]; other site 247156010922 K-X-D-G motif; other site 247156010923 catalytic site [active] 247156010924 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 247156010925 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 247156010926 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 247156010927 Dimer interface [polypeptide binding]; other site 247156010928 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 247156010929 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 247156010930 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 247156010931 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 247156010932 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 247156010933 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 247156010934 catalytic residue [active] 247156010935 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 247156010936 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 247156010937 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 247156010938 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 247156010939 putative acyl-acceptor binding pocket; other site 247156010940 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 247156010941 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 247156010942 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 247156010943 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 247156010944 Transcriptional regulator [Transcription]; Region: LysR; COG0583 247156010945 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 247156010946 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 247156010947 dimerization interface [polypeptide binding]; other site 247156010948 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 247156010949 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 247156010950 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 247156010951 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 247156010952 Ligand binding site [chemical binding]; other site 247156010953 Electron transfer flavoprotein domain; Region: ETF; pfam01012 247156010954 Methyltransferase domain; Region: Methyltransf_23; pfam13489 247156010955 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156010956 S-adenosylmethionine binding site [chemical binding]; other site 247156010957 Uncharacterized conserved protein [Function unknown]; Region: COG1543 247156010958 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 247156010959 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 247156010960 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 247156010961 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 247156010962 PQQ-like domain; Region: PQQ_2; pfam13360 247156010963 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 247156010964 Trp docking motif [polypeptide binding]; other site 247156010965 active site 247156010966 Secretory lipase; Region: LIP; pfam03583 247156010967 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 247156010968 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 247156010969 trimer interface [polypeptide binding]; other site 247156010970 active site 247156010971 substrate binding site [chemical binding]; other site 247156010972 CoA binding site [chemical binding]; other site 247156010973 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 247156010974 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156010975 S-adenosylmethionine binding site [chemical binding]; other site 247156010976 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 247156010977 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 247156010978 substrate binding site [chemical binding]; other site 247156010979 oxyanion hole (OAH) forming residues; other site 247156010980 trimer interface [polypeptide binding]; other site 247156010981 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 247156010982 nudix motif; other site 247156010983 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 247156010984 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156010985 Walker A/P-loop; other site 247156010986 ATP binding site [chemical binding]; other site 247156010987 Q-loop/lid; other site 247156010988 ABC transporter signature motif; other site 247156010989 Walker B; other site 247156010990 D-loop; other site 247156010991 H-loop/switch region; other site 247156010992 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 247156010993 dimer interface [polypeptide binding]; other site 247156010994 putative active site [active] 247156010995 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 247156010996 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 247156010997 phosphoserine phosphatase SerB; Region: serB; TIGR00338 247156010998 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 247156010999 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 247156011000 motif II; other site 247156011001 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 247156011002 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 247156011003 D-pathway; other site 247156011004 Putative ubiquinol binding site [chemical binding]; other site 247156011005 Low-spin heme (heme b) binding site [chemical binding]; other site 247156011006 Putative water exit pathway; other site 247156011007 Binuclear center (heme o3/CuB) [ion binding]; other site 247156011008 K-pathway; other site 247156011009 Putative proton exit pathway; other site 247156011010 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 247156011011 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 247156011012 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 247156011013 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 247156011014 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 247156011015 intersubunit interface [polypeptide binding]; other site 247156011016 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 247156011017 putative active site [active] 247156011018 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 247156011019 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 247156011020 dimer interface [polypeptide binding]; other site 247156011021 putative radical transfer pathway; other site 247156011022 diiron center [ion binding]; other site 247156011023 tyrosyl radical; other site 247156011024 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 247156011025 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 247156011026 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 247156011027 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 247156011028 MgtE intracellular N domain; Region: MgtE_N; smart00924 247156011029 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 247156011030 Divalent cation transporter; Region: MgtE; cl00786 247156011031 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 247156011032 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 247156011033 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 247156011034 DNA binding residues [nucleotide binding] 247156011035 RibD C-terminal domain; Region: RibD_C; cl17279 247156011036 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 247156011037 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 247156011038 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 247156011039 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 247156011040 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 247156011041 protein-splicing catalytic site; other site 247156011042 thioester formation/cholesterol transfer; other site 247156011043 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 247156011044 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 247156011045 Class I ribonucleotide reductase; Region: RNR_I; cd01679 247156011046 active site 247156011047 catalytic residues [active] 247156011048 effector binding site; other site 247156011049 dimer interface [polypeptide binding]; other site 247156011050 R2 peptide binding site; other site 247156011051 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 247156011052 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 247156011053 catalytic residues [active] 247156011054 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 247156011055 Predicted flavoprotein [General function prediction only]; Region: COG0431 247156011056 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156011057 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156011058 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 247156011059 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 247156011060 homodimer interface [polypeptide binding]; other site 247156011061 NAD binding pocket [chemical binding]; other site 247156011062 ATP binding pocket [chemical binding]; other site 247156011063 Mg binding site [ion binding]; other site 247156011064 active-site loop [active] 247156011065 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 247156011066 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 247156011067 YCII-related domain; Region: YCII; cl00999 247156011068 YCII-related domain; Region: YCII; cl00999 247156011069 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 247156011070 MoaE interaction surface [polypeptide binding]; other site 247156011071 MoeB interaction surface [polypeptide binding]; other site 247156011072 thiocarboxylated glycine; other site 247156011073 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 247156011074 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 247156011075 FeS/SAM binding site; other site 247156011076 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 247156011077 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 247156011078 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 247156011079 dimer interface [polypeptide binding]; other site 247156011080 putative functional site; other site 247156011081 putative MPT binding site; other site 247156011082 molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364 247156011083 bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604 247156011084 trimer interface [polypeptide binding]; other site 247156011085 dimer interface [polypeptide binding]; other site 247156011086 putative active site [active] 247156011087 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 247156011088 MPT binding site; other site 247156011089 trimer interface [polypeptide binding]; other site 247156011090 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 247156011091 MoaE homodimer interface [polypeptide binding]; other site 247156011092 MoaD interaction [polypeptide binding]; other site 247156011093 active site residues [active] 247156011094 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 247156011095 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 247156011096 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 247156011097 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 247156011098 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 247156011099 active site 247156011100 metal binding site [ion binding]; metal-binding site 247156011101 short chain dehydrogenase; Provisional; Region: PRK08251 247156011102 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156011103 NAD(P) binding site [chemical binding]; other site 247156011104 active site 247156011105 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 247156011106 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 247156011107 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 247156011108 catalytic residue [active] 247156011109 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 247156011110 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 247156011111 active site 247156011112 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 247156011113 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 247156011114 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 247156011115 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156011116 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 247156011117 Enoylreductase; Region: PKS_ER; smart00829 247156011118 NAD(P) binding site [chemical binding]; other site 247156011119 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156011120 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 247156011121 NAD(P) binding site [chemical binding]; other site 247156011122 active site 247156011123 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 247156011124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156011125 metabolite-proton symporter; Region: 2A0106; TIGR00883 247156011126 putative substrate translocation pore; other site 247156011127 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 247156011128 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 247156011129 DNA binding residues [nucleotide binding] 247156011130 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 247156011131 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 247156011132 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 247156011133 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 247156011134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 247156011135 dimer interface [polypeptide binding]; other site 247156011136 conserved gate region; other site 247156011137 putative PBP binding loops; other site 247156011138 ABC-ATPase subunit interface; other site 247156011139 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156011140 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 247156011141 Walker A/P-loop; other site 247156011142 ATP binding site [chemical binding]; other site 247156011143 Q-loop/lid; other site 247156011144 ABC transporter signature motif; other site 247156011145 Walker B; other site 247156011146 D-loop; other site 247156011147 H-loop/switch region; other site 247156011148 TOBE domain; Region: TOBE; pfam03459 247156011149 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 247156011150 active site 247156011151 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 247156011152 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 247156011153 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 247156011154 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 247156011155 dimer interface [polypeptide binding]; other site 247156011156 active site 247156011157 short chain dehydrogenase; Provisional; Region: PRK07454 247156011158 classical (c) SDRs; Region: SDR_c; cd05233 247156011159 NAD(P) binding site [chemical binding]; other site 247156011160 active site 247156011161 CsbD-like; Region: CsbD; pfam05532 247156011162 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 247156011163 MarR family; Region: MarR; pfam01047 247156011164 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 247156011165 putative active site [active] 247156011166 metal binding site [ion binding]; metal-binding site 247156011167 DoxX; Region: DoxX; pfam07681 247156011168 NAD-dependent deacetylase; Provisional; Region: PRK05333 247156011169 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 247156011170 NAD+ binding site [chemical binding]; other site 247156011171 substrate binding site [chemical binding]; other site 247156011172 Zn binding site [ion binding]; other site 247156011173 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 247156011174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 247156011175 ABC-ATPase subunit interface; other site 247156011176 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156011177 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 247156011178 Walker A/P-loop; other site 247156011179 ATP binding site [chemical binding]; other site 247156011180 Q-loop/lid; other site 247156011181 ABC transporter signature motif; other site 247156011182 Walker B; other site 247156011183 D-loop; other site 247156011184 H-loop/switch region; other site 247156011185 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 247156011186 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 247156011187 Ferredoxin [Energy production and conversion]; Region: COG1146 247156011188 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 247156011189 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 247156011190 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 247156011191 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 247156011192 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 247156011193 Domain of unknown function DUF20; Region: UPF0118; pfam01594 247156011194 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 247156011195 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 247156011196 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 247156011197 putative NAD(P) binding site [chemical binding]; other site 247156011198 active site 247156011199 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 247156011200 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 247156011201 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 247156011202 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 247156011203 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 247156011204 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 247156011205 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 247156011206 GXWXG protein; Region: GXWXG; pfam14231 247156011207 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 247156011208 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156011209 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 247156011210 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 247156011211 active site 247156011212 Phosphotransferase enzyme family; Region: APH; pfam01636 247156011213 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 247156011214 putative active site [active] 247156011215 putative substrate binding site [chemical binding]; other site 247156011216 ATP binding site [chemical binding]; other site 247156011217 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 247156011218 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156011219 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156011220 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 247156011221 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 247156011222 putative NAD(P) binding site [chemical binding]; other site 247156011223 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156011224 Cytochrome P450; Region: p450; cl12078 247156011225 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 247156011226 intracellular protease, PfpI family; Region: PfpI; TIGR01382 247156011227 proposed catalytic triad [active] 247156011228 conserved cys residue [active] 247156011229 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 247156011230 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 247156011231 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 247156011232 Walker A/P-loop; other site 247156011233 ATP binding site [chemical binding]; other site 247156011234 Q-loop/lid; other site 247156011235 ABC transporter signature motif; other site 247156011236 Walker B; other site 247156011237 D-loop; other site 247156011238 H-loop/switch region; other site 247156011239 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 247156011240 active site 247156011241 dimer interface [polypeptide binding]; other site 247156011242 metal binding site [ion binding]; metal-binding site 247156011243 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 247156011244 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 247156011245 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 247156011246 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 247156011247 Helix-turn-helix domain; Region: HTH_18; pfam12833 247156011248 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 247156011249 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 247156011250 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 247156011251 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 247156011252 motif II; other site 247156011253 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 247156011254 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 247156011255 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 247156011256 nucleotide binding site [chemical binding]; other site 247156011257 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 247156011258 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 247156011259 putative metal binding site [ion binding]; other site 247156011260 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 247156011261 Putative esterase; Region: Esterase; pfam00756 247156011262 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 247156011263 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 247156011264 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 247156011265 dimerization interface [polypeptide binding]; other site 247156011266 DPS ferroxidase diiron center [ion binding]; other site 247156011267 ion pore; other site 247156011268 PAS fold; Region: PAS_3; pfam08447 247156011269 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 247156011270 PhoD-like phosphatase; Region: PhoD; pfam09423 247156011271 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 247156011272 putative active site [active] 247156011273 putative metal binding site [ion binding]; other site 247156011274 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 247156011275 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 247156011276 Transcriptional regulator [Transcription]; Region: LysR; COG0583 247156011277 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 247156011278 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 247156011279 putative dimerization interface [polypeptide binding]; other site 247156011280 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156011281 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 247156011282 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 247156011283 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 247156011284 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 247156011285 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 247156011286 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 247156011287 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 247156011288 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156011289 Walker A/P-loop; other site 247156011290 ATP binding site [chemical binding]; other site 247156011291 Q-loop/lid; other site 247156011292 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 247156011293 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156011294 Walker A/P-loop; other site 247156011295 ATP binding site [chemical binding]; other site 247156011296 Q-loop/lid; other site 247156011297 ABC transporter signature motif; other site 247156011298 Walker B; other site 247156011299 D-loop; other site 247156011300 H-loop/switch region; other site 247156011301 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156011302 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156011303 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 247156011304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156011305 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 247156011306 substrate binding pocket [chemical binding]; other site 247156011307 aspartate-rich region 1; other site 247156011308 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 247156011309 catalytic residues [active] 247156011310 substrate binding pocket [chemical binding]; other site 247156011311 aspartate-rich region 2; other site 247156011312 substrate-Mg2+ binding site; other site 247156011313 phytoene desaturase; Region: crtI_fam; TIGR02734 247156011314 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 247156011315 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 247156011316 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 247156011317 substrate binding pocket [chemical binding]; other site 247156011318 chain length determination region; other site 247156011319 substrate-Mg2+ binding site; other site 247156011320 catalytic residues [active] 247156011321 aspartate-rich region 1; other site 247156011322 active site lid residues [active] 247156011323 aspartate-rich region 2; other site 247156011324 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 247156011325 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 247156011326 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 247156011327 putative Zn2+ binding site [ion binding]; other site 247156011328 putative DNA binding site [nucleotide binding]; other site 247156011329 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 247156011330 Proteins of 100 residues with WXG; Region: WXG100; cl02005 247156011331 HEAT repeats; Region: HEAT_2; pfam13646 247156011332 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 247156011333 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 247156011334 DNA binding residues [nucleotide binding] 247156011335 putative dimer interface [polypeptide binding]; other site 247156011336 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 247156011337 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 247156011338 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 247156011339 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 247156011340 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 247156011341 Walker A/P-loop; other site 247156011342 ATP binding site [chemical binding]; other site 247156011343 Q-loop/lid; other site 247156011344 ABC transporter signature motif; other site 247156011345 Walker B; other site 247156011346 D-loop; other site 247156011347 H-loop/switch region; other site 247156011348 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 247156011349 ABC-ATPase subunit interface; other site 247156011350 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 247156011351 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 247156011352 metal ion-dependent adhesion site (MIDAS); other site 247156011353 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 247156011354 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 247156011355 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 247156011356 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 247156011357 TAP-like protein; Region: Abhydrolase_4; pfam08386 247156011358 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 247156011359 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 247156011360 Part of AAA domain; Region: AAA_19; pfam13245 247156011361 Family description; Region: UvrD_C_2; pfam13538 247156011362 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 247156011363 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 247156011364 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 247156011365 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 247156011366 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 247156011367 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 247156011368 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 247156011369 CT1975-like protein; Region: Cas_CT1975; pfam09344 247156011370 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 247156011371 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 247156011372 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 247156011373 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 247156011374 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 247156011375 TIGR02677 family protein; Region: TIGR02677 247156011376 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 247156011377 TIGR02678 family protein; Region: TIGR02678 247156011378 TIGR02680 family protein; Region: TIGR02680 247156011379 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 247156011380 TIGR02679 family protein; Region: TIGR02679 247156011381 Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664 247156011382 putative transposase OrfB; Reviewed; Region: PHA02517 247156011383 Integrase core domain; Region: rve; pfam00665 247156011384 HTH-like domain; Region: HTH_21; pfam13276 247156011385 Integrase core domain; Region: rve; pfam00665 247156011386 Integrase core domain; Region: rve; pfam00665 247156011387 Integrase core domain; Region: rve_3; cl15866 247156011388 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 247156011389 Protein of unknown function (DUF499); Region: DUF499; pfam04465 247156011390 Protein of unknown function DUF262; Region: DUF262; pfam03235 247156011391 Uncharacterized conserved protein [Function unknown]; Region: COG1479 247156011392 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 247156011393 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 247156011394 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 247156011395 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 247156011396 DEAD-like helicases superfamily; Region: DEXDc; smart00487 247156011397 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 247156011398 ATP binding site [chemical binding]; other site 247156011399 putative Mg++ binding site [ion binding]; other site 247156011400 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 247156011401 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 247156011402 nucleotide binding region [chemical binding]; other site 247156011403 ATP-binding site [chemical binding]; other site 247156011404 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 247156011405 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 247156011406 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 247156011407 Presynaptic Site I dimer interface [polypeptide binding]; other site 247156011408 catalytic residues [active] 247156011409 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 247156011410 Synaptic Flat tetramer interface [polypeptide binding]; other site 247156011411 Synaptic Site I dimer interface [polypeptide binding]; other site 247156011412 DNA binding site [nucleotide binding] 247156011413 Recombinase; Region: Recombinase; pfam07508 247156011414 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 247156011415 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 247156011416 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 247156011417 catalytic residues [active] 247156011418 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156011419 Major Facilitator Superfamily; Region: MFS_1; pfam07690 247156011420 putative substrate translocation pore; other site 247156011421 phosphoglucomutase; Validated; Region: PRK07564 247156011422 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 247156011423 active site 247156011424 substrate binding site [chemical binding]; other site 247156011425 metal binding site [ion binding]; metal-binding site 247156011426 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 247156011427 CrcB-like protein; Region: CRCB; pfam02537 247156011428 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156011429 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156011430 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 247156011431 FAD binding domain; Region: FAD_binding_4; pfam01565 247156011432 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 247156011433 NAD-dependent deacetylase; Provisional; Region: PRK00481 247156011434 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 247156011435 NAD+ binding site [chemical binding]; other site 247156011436 substrate binding site [chemical binding]; other site 247156011437 Zn binding site [ion binding]; other site 247156011438 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 247156011439 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 247156011440 Low molecular weight phosphatase family; Region: LMWPc; cd00115 247156011441 active site 247156011442 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 247156011443 Mitomycin C resistance protein (MRD); Region: MRD; cd07235 247156011444 dimer interface [polypeptide binding]; other site 247156011445 ligand binding site [chemical binding]; other site 247156011446 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 247156011447 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 247156011448 CoenzymeA binding site [chemical binding]; other site 247156011449 subunit interaction site [polypeptide binding]; other site 247156011450 PHB binding site; other site 247156011451 threonine dehydratase; Provisional; Region: PRK08246 247156011452 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 247156011453 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 247156011454 catalytic residue [active] 247156011455 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 247156011456 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 247156011457 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 247156011458 FAD binding domain; Region: FAD_binding_4; pfam01565 247156011459 Berberine and berberine like; Region: BBE; pfam08031 247156011460 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 247156011461 nucleoside/Zn binding site; other site 247156011462 dimer interface [polypeptide binding]; other site 247156011463 catalytic motif [active] 247156011464 Transcriptional regulators [Transcription]; Region: GntR; COG1802 247156011465 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 247156011466 DNA-binding site [nucleotide binding]; DNA binding site 247156011467 FCD domain; Region: FCD; pfam07729 247156011468 Helix-turn-helix domain; Region: HTH_18; pfam12833 247156011469 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 247156011470 Methyltransferase domain; Region: Methyltransf_31; pfam13847 247156011471 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156011472 S-adenosylmethionine binding site [chemical binding]; other site 247156011473 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 247156011474 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 247156011475 putative DNA binding site [nucleotide binding]; other site 247156011476 putative Zn2+ binding site [ion binding]; other site 247156011477 AsnC family; Region: AsnC_trans_reg; pfam01037 247156011478 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 247156011479 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156011480 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156011481 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 247156011482 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 247156011483 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 247156011484 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 247156011485 ligand binding site [chemical binding]; other site 247156011486 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 247156011487 SmpB-tmRNA interface; other site 247156011488 Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain; Region: MPP_ACP5; cd07378 247156011489 active site 247156011490 metal binding site [ion binding]; metal-binding site 247156011491 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 247156011492 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 247156011493 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 247156011494 ATP binding site [chemical binding]; other site 247156011495 putative Mg++ binding site [ion binding]; other site 247156011496 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 247156011497 nucleotide binding region [chemical binding]; other site 247156011498 ATP-binding site [chemical binding]; other site 247156011499 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 247156011500 HRDC domain; Region: HRDC; pfam00570 247156011501 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 247156011502 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 247156011503 FtsX-like permease family; Region: FtsX; pfam02687 247156011504 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 247156011505 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156011506 Walker A/P-loop; other site 247156011507 ATP binding site [chemical binding]; other site 247156011508 Q-loop/lid; other site 247156011509 ABC transporter signature motif; other site 247156011510 Walker B; other site 247156011511 D-loop; other site 247156011512 H-loop/switch region; other site 247156011513 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 247156011514 Mechanosensitive ion channel; Region: MS_channel; pfam00924 247156011515 peptide chain release factor 2; Validated; Region: prfB; PRK00578 247156011516 This domain is found in peptide chain release factors; Region: PCRF; smart00937 247156011517 RF-1 domain; Region: RF-1; pfam00472 247156011518 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156011519 salt bridge; other site 247156011520 non-specific DNA binding site [nucleotide binding]; other site 247156011521 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 247156011522 sequence-specific DNA binding site [nucleotide binding]; other site 247156011523 Predicted flavoprotein [General function prediction only]; Region: COG0431 247156011524 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 247156011525 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 247156011526 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 247156011527 active site 247156011528 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156011529 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156011530 active site 247156011531 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156011532 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156011533 active site 247156011534 Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441 247156011535 active site 247156011536 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 247156011537 putative catalytic site [active] 247156011538 putative phosphate binding site [ion binding]; other site 247156011539 putative metal binding site [ion binding]; other site 247156011540 acyl-CoA synthetase; Validated; Region: PRK07788 247156011541 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 247156011542 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 247156011543 acyl-activating enzyme (AAE) consensus motif; other site 247156011544 putative AMP binding site [chemical binding]; other site 247156011545 putative active site [active] 247156011546 putative CoA binding site [chemical binding]; other site 247156011547 acyl-CoA synthetase; Validated; Region: PRK07788 247156011548 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 247156011549 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 247156011550 acyl-activating enzyme (AAE) consensus motif; other site 247156011551 acyl-activating enzyme (AAE) consensus motif; other site 247156011552 AMP binding site [chemical binding]; other site 247156011553 active site 247156011554 CoA binding site [chemical binding]; other site 247156011555 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 247156011556 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 247156011557 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 247156011558 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 247156011559 putative hydrophobic ligand binding site [chemical binding]; other site 247156011560 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 247156011561 Na binding site [ion binding]; other site 247156011562 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 247156011563 galactokinase; Provisional; Region: PRK03817 247156011564 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 247156011565 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 247156011566 metal binding site [ion binding]; metal-binding site 247156011567 active site 247156011568 I-site; other site 247156011569 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 247156011570 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 247156011571 NAD binding site [chemical binding]; other site 247156011572 substrate binding site [chemical binding]; other site 247156011573 catalytic Zn binding site [ion binding]; other site 247156011574 structural Zn binding site [ion binding]; other site 247156011575 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 247156011576 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 247156011577 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 247156011578 acyl-activating enzyme (AAE) consensus motif; other site 247156011579 acyl-activating enzyme (AAE) consensus motif; other site 247156011580 AMP binding site [chemical binding]; other site 247156011581 active site 247156011582 CoA binding site [chemical binding]; other site 247156011583 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 247156011584 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 247156011585 active site 247156011586 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 247156011587 Predicted membrane protein [Function unknown]; Region: COG2259 247156011588 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 247156011589 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 247156011590 NAD(P) binding site [chemical binding]; other site 247156011591 catalytic residues [active] 247156011592 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 247156011593 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156011594 non-specific DNA binding site [nucleotide binding]; other site 247156011595 salt bridge; other site 247156011596 sequence-specific DNA binding site [nucleotide binding]; other site 247156011597 Cupin domain; Region: Cupin_2; pfam07883 247156011598 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 247156011599 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 247156011600 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 247156011601 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 247156011602 Cytochrome P450; Region: p450; cl12078 247156011603 3-oxo-5-alpha-steroid 4-dehydrogenase; Region: Steroid_dh; cl17474 247156011604 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 247156011605 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 247156011606 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 247156011607 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 247156011608 SPRY domain; Region: SPRY; cl02614 247156011609 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 247156011610 hypothetical protein; Provisional; Region: PRK12438 247156011611 hypothetical protein; Validated; Region: PRK00068 247156011612 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 247156011613 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 247156011614 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 247156011615 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 247156011616 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 247156011617 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 247156011618 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 247156011619 ABC1 family; Region: ABC1; pfam03109 247156011620 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 247156011621 active site 247156011622 substrate binding site [chemical binding]; other site 247156011623 ATP binding site [chemical binding]; other site 247156011624 Transcription factor WhiB; Region: Whib; pfam02467 247156011625 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 247156011626 Part of AAA domain; Region: AAA_19; pfam13245 247156011627 Family description; Region: UvrD_C_2; pfam13538 247156011628 HRDC domain; Region: HRDC; pfam00570 247156011629 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 247156011630 catalytic residues [active] 247156011631 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 247156011632 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 247156011633 putative NADH binding site [chemical binding]; other site 247156011634 putative active site [active] 247156011635 nudix motif; other site 247156011636 putative metal binding site [ion binding]; other site 247156011637 Ion channel; Region: Ion_trans_2; pfam07885 247156011638 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 247156011639 TrkA-N domain; Region: TrkA_N; pfam02254 247156011640 Predicted membrane protein [Function unknown]; Region: COG4270 247156011641 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 247156011642 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 247156011643 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 247156011644 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 247156011645 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 247156011646 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 247156011647 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 247156011648 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 247156011649 catalytic site [active] 247156011650 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 247156011651 active site 247156011652 DNA binding site [nucleotide binding] 247156011653 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 247156011654 active site 247156011655 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 247156011656 active site 247156011657 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 247156011658 GTP binding site; other site 247156011659 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 247156011660 dimer interface [polypeptide binding]; other site 247156011661 putative functional site; other site 247156011662 putative MPT binding site; other site 247156011663 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 247156011664 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 247156011665 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 247156011666 intersubunit interface [polypeptide binding]; other site 247156011667 active site 247156011668 Zn2+ binding site [ion binding]; other site 247156011669 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 247156011670 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 247156011671 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 247156011672 motif II; other site 247156011673 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 247156011674 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156011675 non-specific DNA binding site [nucleotide binding]; other site 247156011676 salt bridge; other site 247156011677 sequence-specific DNA binding site [nucleotide binding]; other site 247156011678 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 247156011679 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 247156011680 [4Fe-4S] binding site [ion binding]; other site 247156011681 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 247156011682 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 247156011683 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 247156011684 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 247156011685 molybdopterin cofactor binding site; other site 247156011686 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 247156011687 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 247156011688 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 247156011689 Abi-like protein; Region: Abi_2; pfam07751 247156011690 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 247156011691 dimer interface [polypeptide binding]; other site 247156011692 Putative esterase; Region: Esterase; pfam00756 247156011693 S-formylglutathione hydrolase; Region: PLN02442 247156011694 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 247156011695 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 247156011696 putative active site [active] 247156011697 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 247156011698 putative active site [active] 247156011699 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 247156011700 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 247156011701 active site 247156011702 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 247156011703 DNA binding site [nucleotide binding] 247156011704 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 247156011705 nitrite reductase subunit NirD; Provisional; Region: PRK14989 247156011706 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 247156011707 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 247156011708 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 247156011709 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 247156011710 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 247156011711 Transcriptional regulators [Transcription]; Region: FadR; COG2186 247156011712 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 247156011713 DNA-binding site [nucleotide binding]; DNA binding site 247156011714 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 247156011715 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 247156011716 TIGR02569 family protein; Region: TIGR02569_actnb 247156011717 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 247156011718 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 247156011719 ATP binding site [chemical binding]; other site 247156011720 substrate interface [chemical binding]; other site 247156011721 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 247156011722 active site residue [active] 247156011723 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 247156011724 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156011725 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156011726 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 247156011727 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 247156011728 Poly(3-hydroxyalkanoate) synthetase [Lipid metabolism]; Region: PhaC; COG3243 247156011729 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 247156011730 DEAD-like helicases superfamily; Region: DEXDc; smart00487 247156011731 ATP binding site [chemical binding]; other site 247156011732 Mg++ binding site [ion binding]; other site 247156011733 motif III; other site 247156011734 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 247156011735 nucleotide binding region [chemical binding]; other site 247156011736 ATP-binding site [chemical binding]; other site 247156011737 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 247156011738 catalytic core [active] 247156011739 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 247156011740 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 247156011741 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 247156011742 Active_site [active] 247156011743 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 247156011744 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 247156011745 Transcription factor WhiB; Region: Whib; pfam02467 247156011746 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 247156011747 PAS domain S-box; Region: sensory_box; TIGR00229 247156011748 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 247156011749 putative active site [active] 247156011750 heme pocket [chemical binding]; other site 247156011751 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 247156011752 Histidine kinase; Region: HisKA_2; pfam07568 247156011753 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 247156011754 ATP binding site [chemical binding]; other site 247156011755 Mg2+ binding site [ion binding]; other site 247156011756 G-X-G motif; other site 247156011757 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 247156011758 carboxyltransferase (CT) interaction site; other site 247156011759 biotinylation site [posttranslational modification]; other site 247156011760 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 247156011761 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 247156011762 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 247156011763 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 247156011764 DNA binding residues [nucleotide binding] 247156011765 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 247156011766 putative deacylase active site [active] 247156011767 Uncharacterized conserved protein [Function unknown]; Region: COG2135 247156011768 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 247156011769 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 247156011770 NAD(P) binding site [chemical binding]; other site 247156011771 catalytic residues [active] 247156011772 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 247156011773 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 247156011774 hinge; other site 247156011775 active site 247156011776 Predicted GTPases [General function prediction only]; Region: COG1162 247156011777 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 247156011778 GTPase/Zn-binding domain interface [polypeptide binding]; other site 247156011779 GTP/Mg2+ binding site [chemical binding]; other site 247156011780 G4 box; other site 247156011781 G5 box; other site 247156011782 G1 box; other site 247156011783 Switch I region; other site 247156011784 G2 box; other site 247156011785 G3 box; other site 247156011786 Switch II region; other site 247156011787 glutamate dehydrogenase; Provisional; Region: PRK09414 247156011788 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 247156011789 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 247156011790 NAD(P) binding pocket [chemical binding]; other site 247156011791 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156011792 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 247156011793 Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862 247156011794 putative hydrophobic ligand binding site [chemical binding]; other site 247156011795 Uncharacterized protein conserved in bacteria (DUF2247); Region: DUF2247; pfam10004 247156011796 FAD binding domain; Region: FAD_binding_4; pfam01565 247156011797 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 247156011798 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 247156011799 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 247156011800 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 247156011801 DNA binding residues [nucleotide binding] 247156011802 dimerization interface [polypeptide binding]; other site 247156011803 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 247156011804 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 247156011805 ATP binding site [chemical binding]; other site 247156011806 putative Mg++ binding site [ion binding]; other site 247156011807 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 247156011808 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 247156011809 nucleotide binding region [chemical binding]; other site 247156011810 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 247156011811 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 247156011812 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 247156011813 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 247156011814 FAD binding pocket [chemical binding]; other site 247156011815 FAD binding motif [chemical binding]; other site 247156011816 phosphate binding motif [ion binding]; other site 247156011817 beta-alpha-beta structure motif; other site 247156011818 NAD binding pocket [chemical binding]; other site 247156011819 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 247156011820 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 247156011821 catalytic loop [active] 247156011822 iron binding site [ion binding]; other site 247156011823 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 247156011824 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 247156011825 putative di-iron ligands [ion binding]; other site 247156011826 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 247156011827 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 247156011828 putative di-iron ligands [ion binding]; other site 247156011829 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 247156011830 putative FMN binding site [chemical binding]; other site 247156011831 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 247156011832 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 247156011833 dimer interface [polypeptide binding]; other site 247156011834 active site 247156011835 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 247156011836 30S subunit binding site; other site 247156011837 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 247156011838 lipoprotein LpqB; Provisional; Region: PRK13616 247156011839 Sporulation and spore germination; Region: Germane; pfam10646 247156011840 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 247156011841 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 247156011842 dimerization interface [polypeptide binding]; other site 247156011843 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 247156011844 dimer interface [polypeptide binding]; other site 247156011845 phosphorylation site [posttranslational modification] 247156011846 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 247156011847 ATP binding site [chemical binding]; other site 247156011848 Mg2+ binding site [ion binding]; other site 247156011849 G-X-G motif; other site 247156011850 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 247156011851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 247156011852 active site 247156011853 phosphorylation site [posttranslational modification] 247156011854 intermolecular recognition site; other site 247156011855 dimerization interface [polypeptide binding]; other site 247156011856 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 247156011857 DNA binding site [nucleotide binding] 247156011858 thymidylate kinase; Validated; Region: PRK07933 247156011859 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 247156011860 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 247156011861 homotetramer interface [polypeptide binding]; other site 247156011862 ligand binding site [chemical binding]; other site 247156011863 catalytic site [active] 247156011864 NAD binding site [chemical binding]; other site 247156011865 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 247156011866 Fatty acid desaturase; Region: FA_desaturase; pfam00487 247156011867 Di-iron ligands [ion binding]; other site 247156011868 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156011869 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156011870 Rubredoxin [Energy production and conversion]; Region: COG1773 247156011871 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 247156011872 iron binding site [ion binding]; other site 247156011873 Rubredoxin [Energy production and conversion]; Region: COG1773 247156011874 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 247156011875 iron binding site [ion binding]; other site 247156011876 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 247156011877 Fatty acid desaturase; Region: FA_desaturase; pfam00487 247156011878 Di-iron ligands [ion binding]; other site 247156011879 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 247156011880 nudix motif; other site 247156011881 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 247156011882 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 247156011883 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 247156011884 putative FMN binding site [chemical binding]; other site 247156011885 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 247156011886 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 247156011887 phosphate binding site [ion binding]; other site 247156011888 dimer interface [polypeptide binding]; other site 247156011889 substrate binding site [chemical binding]; other site 247156011890 Transcription factor WhiB; Region: Whib; pfam02467 247156011891 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 247156011892 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 247156011893 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 247156011894 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 247156011895 active site 247156011896 substrate binding site [chemical binding]; other site 247156011897 metal binding site [ion binding]; metal-binding site 247156011898 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 247156011899 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 247156011900 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 247156011901 Cation efflux family; Region: Cation_efflux; pfam01545 247156011902 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 247156011903 H+ Antiporter protein; Region: 2A0121; TIGR00900 247156011904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156011905 putative substrate translocation pore; other site 247156011906 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 247156011907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156011908 putative substrate translocation pore; other site 247156011909 YtkA-like; Region: YtkA; pfam13115 247156011910 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 247156011911 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 247156011912 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 247156011913 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 247156011914 ATP binding site [chemical binding]; other site 247156011915 G-X-G motif; other site 247156011916 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 247156011917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 247156011918 active site 247156011919 phosphorylation site [posttranslational modification] 247156011920 intermolecular recognition site; other site 247156011921 dimerization interface [polypeptide binding]; other site 247156011922 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 247156011923 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 247156011924 active site 247156011925 Substrate binding site; other site 247156011926 Mg++ binding site; other site 247156011927 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 247156011928 putative trimer interface [polypeptide binding]; other site 247156011929 putative CoA binding site [chemical binding]; other site 247156011930 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 247156011931 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 247156011932 Probable Catalytic site; other site 247156011933 metal-binding site 247156011934 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 247156011935 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 247156011936 NADP binding site [chemical binding]; other site 247156011937 active site 247156011938 putative substrate binding site [chemical binding]; other site 247156011939 Transcriptional regulator [Transcription]; Region: LytR; COG1316 247156011940 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 247156011941 TIGR03089 family protein; Region: TIGR03089 247156011942 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 247156011943 Cytochrome P450; Region: p450; cl12078 247156011944 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 247156011945 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 247156011946 substrate binding pocket [chemical binding]; other site 247156011947 catalytic triad [active] 247156011948 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 247156011949 Rdx family; Region: Rdx; cl01407 247156011950 hypothetical protein; Provisional; Region: PRK01842 247156011951 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 247156011952 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 247156011953 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 247156011954 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 247156011955 RPB1 interaction site [polypeptide binding]; other site 247156011956 RPB10 interaction site [polypeptide binding]; other site 247156011957 RPB11 interaction site [polypeptide binding]; other site 247156011958 RPB3 interaction site [polypeptide binding]; other site 247156011959 RPB12 interaction site [polypeptide binding]; other site 247156011960 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156011961 AAA domain; Region: AAA_23; pfam13476 247156011962 Walker A/P-loop; other site 247156011963 ATP binding site [chemical binding]; other site 247156011964 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156011965 ABC transporter signature motif; other site 247156011966 Walker B; other site 247156011967 D-loop; other site 247156011968 H-loop/switch region; other site 247156011969 MoxR-like ATPases [General function prediction only]; Region: COG0714 247156011970 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 247156011971 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 247156011972 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 247156011973 metal ion-dependent adhesion site (MIDAS); other site 247156011974 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 247156011975 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 247156011976 FtsX-like permease family; Region: FtsX; pfam02687 247156011977 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 247156011978 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 247156011979 Walker A/P-loop; other site 247156011980 ATP binding site [chemical binding]; other site 247156011981 Q-loop/lid; other site 247156011982 ABC transporter signature motif; other site 247156011983 Walker B; other site 247156011984 D-loop; other site 247156011985 H-loop/switch region; other site 247156011986 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 247156011987 AAA ATPase domain; Region: AAA_16; pfam13191 247156011988 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156011989 hypothetical protein; Validated; Region: PRK07121 247156011990 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 247156011991 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 247156011992 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 247156011993 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 247156011994 short chain dehydrogenase; Provisional; Region: PRK07774 247156011995 classical (c) SDRs; Region: SDR_c; cd05233 247156011996 NAD(P) binding site [chemical binding]; other site 247156011997 active site 247156011998 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 247156011999 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 247156012000 NAD binding site [chemical binding]; other site 247156012001 catalytic residues [active] 247156012002 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 247156012003 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 247156012004 NAD(P) binding site [chemical binding]; other site 247156012005 catalytic residues [active] 247156012006 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 247156012007 catalytic residues [active] 247156012008 dimer interface [polypeptide binding]; other site 247156012009 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 247156012010 Catalytic domain of Protein Kinases; Region: PKc; cd00180 247156012011 active site 247156012012 ATP binding site [chemical binding]; other site 247156012013 substrate binding site [chemical binding]; other site 247156012014 activation loop (A-loop); other site 247156012015 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 247156012016 Catalytic domain of Protein Kinases; Region: PKc; cd00180 247156012017 active site 247156012018 ATP binding site [chemical binding]; other site 247156012019 substrate binding site [chemical binding]; other site 247156012020 activation loop (A-loop); other site 247156012021 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 247156012022 Catalytic domain of Protein Kinases; Region: PKc; cd00180 247156012023 active site 247156012024 ATP binding site [chemical binding]; other site 247156012025 substrate binding site [chemical binding]; other site 247156012026 activation loop (A-loop); other site 247156012027 endonuclease IV; Provisional; Region: PRK01060 247156012028 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 247156012029 AP (apurinic/apyrimidinic) site pocket; other site 247156012030 DNA interaction; other site 247156012031 Metal-binding active site; metal-binding site 247156012032 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 247156012033 active site 247156012034 catalytic residues [active] 247156012035 metal binding site [ion binding]; metal-binding site 247156012036 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 247156012037 Coenzyme A binding pocket [chemical binding]; other site 247156012038 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 247156012039 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 247156012040 active site 247156012041 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 247156012042 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156012043 active site 247156012044 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 247156012045 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 247156012046 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 247156012047 active site 247156012048 Predicted amidohydrolase [General function prediction only]; Region: COG0388 247156012049 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 247156012050 putative active site [active] 247156012051 catalytic triad [active] 247156012052 putative dimer interface [polypeptide binding]; other site 247156012053 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 247156012054 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 247156012055 ATP binding site [chemical binding]; other site 247156012056 Mg++ binding site [ion binding]; other site 247156012057 motif III; other site 247156012058 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 247156012059 nucleotide binding region [chemical binding]; other site 247156012060 ATP-binding site [chemical binding]; other site 247156012061 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 247156012062 putative RNA binding site [nucleotide binding]; other site 247156012063 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 247156012064 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 247156012065 AAA domain; Region: AAA_12; pfam13087 247156012066 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 247156012067 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 247156012068 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 247156012069 catalytic residue [active] 247156012070 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 247156012071 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 247156012072 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 247156012073 AMP-binding enzyme; Region: AMP-binding; pfam00501 247156012074 acyl-activating enzyme (AAE) consensus motif; other site 247156012075 active site 247156012076 AMP binding site [chemical binding]; other site 247156012077 CoA binding site [chemical binding]; other site 247156012078 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 247156012079 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 247156012080 substrate binding site [chemical binding]; other site 247156012081 oxyanion hole (OAH) forming residues; other site 247156012082 trimer interface [polypeptide binding]; other site 247156012083 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 247156012084 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 247156012085 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 247156012086 putative dimer interface [polypeptide binding]; other site 247156012087 N-terminal domain interface [polypeptide binding]; other site 247156012088 putative substrate binding pocket (H-site) [chemical binding]; other site 247156012089 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 247156012090 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156012091 Walker A/P-loop; other site 247156012092 ATP binding site [chemical binding]; other site 247156012093 Q-loop/lid; other site 247156012094 ABC transporter signature motif; other site 247156012095 Walker B; other site 247156012096 D-loop; other site 247156012097 H-loop/switch region; other site 247156012098 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 247156012099 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156012100 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 247156012101 Walker A/P-loop; other site 247156012102 ATP binding site [chemical binding]; other site 247156012103 Q-loop/lid; other site 247156012104 ABC transporter signature motif; other site 247156012105 Walker B; other site 247156012106 D-loop; other site 247156012107 H-loop/switch region; other site 247156012108 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 247156012109 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 247156012110 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156012111 Walker A/P-loop; other site 247156012112 ATP binding site [chemical binding]; other site 247156012113 Q-loop/lid; other site 247156012114 ABC transporter signature motif; other site 247156012115 Walker B; other site 247156012116 D-loop; other site 247156012117 H-loop/switch region; other site 247156012118 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 247156012119 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 247156012120 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 247156012121 TPP-binding site [chemical binding]; other site 247156012122 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 247156012123 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 247156012124 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 247156012125 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 247156012126 active site 247156012127 KMSKS motif; other site 247156012128 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 247156012129 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 247156012130 putative metal binding site [ion binding]; other site 247156012131 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156012132 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156012133 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 247156012134 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 247156012135 short chain dehydrogenase; Provisional; Region: PRK06181 247156012136 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156012137 NAD(P) binding site [chemical binding]; other site 247156012138 active site 247156012139 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 247156012140 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 247156012141 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 247156012142 acyl-activating enzyme (AAE) consensus motif; other site 247156012143 putative AMP binding site [chemical binding]; other site 247156012144 putative active site [active] 247156012145 putative CoA binding site [chemical binding]; other site 247156012146 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 247156012147 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 247156012148 Moco binding site; other site 247156012149 metal coordination site [ion binding]; other site 247156012150 dimerization interface [polypeptide binding]; other site 247156012151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156012152 Major Facilitator Superfamily; Region: MFS_1; pfam07690 247156012153 putative substrate translocation pore; other site 247156012154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156012155 Predicted transcriptional regulators [Transcription]; Region: COG1695 247156012156 Transcriptional regulator PadR-like family; Region: PadR; cl17335 247156012157 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 247156012158 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 247156012159 Malic enzyme, N-terminal domain; Region: malic; pfam00390 247156012160 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 247156012161 putative NAD(P) binding site [chemical binding]; other site 247156012162 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 247156012163 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 247156012164 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 247156012165 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 247156012166 active site 247156012167 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 247156012168 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 247156012169 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 247156012170 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 247156012171 oligomer interface [polypeptide binding]; other site 247156012172 metal binding site [ion binding]; metal-binding site 247156012173 metal binding site [ion binding]; metal-binding site 247156012174 putative Cl binding site [ion binding]; other site 247156012175 basic sphincter; other site 247156012176 hydrophobic gate; other site 247156012177 periplasmic entrance; other site 247156012178 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 247156012179 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 247156012180 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 247156012181 MgtE intracellular N domain; Region: MgtE_N; smart00924 247156012182 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 247156012183 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 247156012184 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 247156012185 N-acetyl-D-glucosamine binding site [chemical binding]; other site 247156012186 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 247156012187 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 247156012188 N-acetyl-D-glucosamine binding site [chemical binding]; other site 247156012189 Domain of unknown function DUF59; Region: DUF59; pfam01883 247156012190 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 247156012191 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 247156012192 DivIVA domain; Region: DivI1A_domain; TIGR03544 247156012193 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 247156012194 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 247156012195 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 247156012196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 247156012197 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 247156012198 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 247156012199 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 247156012200 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 247156012201 ligand binding site; other site 247156012202 oligomer interface; other site 247156012203 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 247156012204 dimer interface [polypeptide binding]; other site 247156012205 N-terminal domain interface [polypeptide binding]; other site 247156012206 sulfate 1 binding site; other site 247156012207 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 247156012208 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156012209 S-adenosylmethionine binding site [chemical binding]; other site 247156012210 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 247156012211 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 247156012212 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 247156012213 DNA binding residues [nucleotide binding] 247156012214 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 247156012215 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 247156012216 sec-independent translocase; Provisional; Region: PRK03100 247156012217 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 247156012218 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 247156012219 XdhC Rossmann domain; Region: XdhC_C; pfam13478 247156012220 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 247156012221 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 247156012222 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 247156012223 dihydropteroate synthase; Region: DHPS; TIGR01496 247156012224 substrate binding pocket [chemical binding]; other site 247156012225 dimer interface [polypeptide binding]; other site 247156012226 inhibitor binding site; inhibition site 247156012227 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 247156012228 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 247156012229 acyl-activating enzyme (AAE) consensus motif; other site 247156012230 putative AMP binding site [chemical binding]; other site 247156012231 putative active site [active] 247156012232 putative CoA binding site [chemical binding]; other site 247156012233 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 247156012234 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 247156012235 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 247156012236 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 247156012237 metal binding site [ion binding]; metal-binding site 247156012238 putative dimer interface [polypeptide binding]; other site 247156012239 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 247156012240 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 247156012241 putative trimer interface [polypeptide binding]; other site 247156012242 putative CoA binding site [chemical binding]; other site 247156012243 acyl-CoA synthetase; Validated; Region: PRK07787 247156012244 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 247156012245 acyl-activating enzyme (AAE) consensus motif; other site 247156012246 AMP binding site [chemical binding]; other site 247156012247 active site 247156012248 CoA binding site [chemical binding]; other site 247156012249 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 247156012250 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156012251 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156012252 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 247156012253 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 247156012254 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 247156012255 Glutamate binding site [chemical binding]; other site 247156012256 NAD binding site [chemical binding]; other site 247156012257 catalytic residues [active] 247156012258 hypothetical protein; Provisional; Region: PHA02754 247156012259 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 247156012260 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 247156012261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156012262 homodimer interface [polypeptide binding]; other site 247156012263 catalytic residue [active] 247156012264 Ferredoxin [Energy production and conversion]; Region: COG1146 247156012265 4Fe-4S binding domain; Region: Fer4; pfam00037 247156012266 FO synthase; Reviewed; Region: fbiC; PRK09234 247156012267 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 247156012268 FeS/SAM binding site; other site 247156012269 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 247156012270 FeS/SAM binding site; other site 247156012271 Bacterial PH domain; Region: DUF304; cl01348 247156012272 Bacterial PH domain; Region: DUF304; pfam03703 247156012273 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 247156012274 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 247156012275 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 247156012276 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 247156012277 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 247156012278 G1 box; other site 247156012279 putative GEF interaction site [polypeptide binding]; other site 247156012280 GTP/Mg2+ binding site [chemical binding]; other site 247156012281 Switch I region; other site 247156012282 G2 box; other site 247156012283 G3 box; other site 247156012284 Switch II region; other site 247156012285 G4 box; other site 247156012286 G5 box; other site 247156012287 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 247156012288 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 247156012289 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 247156012290 aromatic arch; other site 247156012291 DCoH dimer interaction site [polypeptide binding]; other site 247156012292 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 247156012293 DCoH tetramer interaction site [polypeptide binding]; other site 247156012294 substrate binding site [chemical binding]; other site 247156012295 mannosyltransferase; Provisional; Region: pimE; PRK13375 247156012296 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 247156012297 Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; cl01776 247156012298 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156012299 Methyltransferase domain; Region: Methyltransf_31; pfam13847 247156012300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156012301 S-adenosylmethionine binding site [chemical binding]; other site 247156012302 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 247156012303 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 247156012304 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156012305 non-specific DNA binding site [nucleotide binding]; other site 247156012306 salt bridge; other site 247156012307 sequence-specific DNA binding site [nucleotide binding]; other site 247156012308 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156012309 non-specific DNA binding site [nucleotide binding]; other site 247156012310 salt bridge; other site 247156012311 sequence-specific DNA binding site [nucleotide binding]; other site 247156012312 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 247156012313 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 247156012314 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 247156012315 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 247156012316 CoenzymeA binding site [chemical binding]; other site 247156012317 subunit interaction site [polypeptide binding]; other site 247156012318 PHB binding site; other site 247156012319 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 247156012320 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 247156012321 Archaeal ATPase; Region: Arch_ATPase; pfam01637 247156012322 AAA ATPase domain; Region: AAA_16; pfam13191 247156012323 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 247156012324 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 247156012325 RibD C-terminal domain; Region: RibD_C; cl17279 247156012326 Predicted transcriptional regulators [Transcription]; Region: COG1733 247156012327 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 247156012328 GTP-binding protein YchF; Reviewed; Region: PRK09601 247156012329 YchF GTPase; Region: YchF; cd01900 247156012330 G1 box; other site 247156012331 GTP/Mg2+ binding site [chemical binding]; other site 247156012332 Switch I region; other site 247156012333 G2 box; other site 247156012334 Switch II region; other site 247156012335 G3 box; other site 247156012336 G4 box; other site 247156012337 G5 box; other site 247156012338 Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071 247156012339 Helix-turn-helix domain; Region: HTH_18; pfam12833 247156012340 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 247156012341 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 247156012342 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 247156012343 carbon starvation protein A; Provisional; Region: PRK15015 247156012344 Carbon starvation protein CstA; Region: CstA; pfam02554 247156012345 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 247156012346 Protein of unknown function (DUF466); Region: DUF466; pfam04328 247156012347 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 247156012348 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 247156012349 AlkA N-terminal domain; Region: AlkA_N; pfam06029 247156012350 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 247156012351 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 247156012352 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 247156012353 DNA binding site [nucleotide binding] 247156012354 active site 247156012355 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156012356 AAA domain; Region: AAA_23; pfam13476 247156012357 Walker A/P-loop; other site 247156012358 ATP binding site [chemical binding]; other site 247156012359 Q-loop/lid; other site 247156012360 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 247156012361 ABC transporter signature motif; other site 247156012362 Walker B; other site 247156012363 D-loop; other site 247156012364 H-loop/switch region; other site 247156012365 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 247156012366 active site 247156012367 metal binding site [ion binding]; metal-binding site 247156012368 DNA binding site [nucleotide binding] 247156012369 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 247156012370 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 247156012371 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 247156012372 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 247156012373 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 247156012374 generic binding surface II; other site 247156012375 generic binding surface I; other site 247156012376 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 247156012377 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 247156012378 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 247156012379 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 247156012380 putative active site [active] 247156012381 fumarate hydratase; Reviewed; Region: fumC; PRK00485 247156012382 Class II fumarases; Region: Fumarase_classII; cd01362 247156012383 active site 247156012384 tetramer interface [polypeptide binding]; other site 247156012385 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 247156012386 putative active site [active] 247156012387 SnoaL-like domain; Region: SnoaL_3; pfam13474 247156012388 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 247156012389 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156012390 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 247156012391 NAD(P) binding site [chemical binding]; other site 247156012392 active site 247156012393 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 247156012394 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 247156012395 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 247156012396 putative active site [active] 247156012397 PhoH-like protein; Region: PhoH; pfam02562 247156012398 LGFP repeat; Region: LGFP; pfam08310 247156012399 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 247156012400 dinuclear metal binding motif [ion binding]; other site 247156012401 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 247156012402 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 247156012403 dimer interface [polypeptide binding]; other site 247156012404 active site 247156012405 glycine-pyridoxal phosphate binding site [chemical binding]; other site 247156012406 folate binding site [chemical binding]; other site 247156012407 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156012408 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156012409 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 247156012410 CoenzymeA binding site [chemical binding]; other site 247156012411 subunit interaction site [polypeptide binding]; other site 247156012412 PHB binding site; other site 247156012413 pantothenate kinase; Provisional; Region: PRK05439 247156012414 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 247156012415 ATP-binding site [chemical binding]; other site 247156012416 CoA-binding site [chemical binding]; other site 247156012417 Mg2+-binding site [ion binding]; other site 247156012418 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 247156012419 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 247156012420 catalytic residue [active] 247156012421 putative FPP diphosphate binding site; other site 247156012422 putative FPP binding hydrophobic cleft; other site 247156012423 dimer interface [polypeptide binding]; other site 247156012424 putative IPP diphosphate binding site; other site 247156012425 Haemolysin-III related; Region: HlyIII; cl03831 247156012426 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 247156012427 dimerization interface [polypeptide binding]; other site 247156012428 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 247156012429 cyclase homology domain; Region: CHD; cd07302 247156012430 nucleotidyl binding site; other site 247156012431 metal binding site [ion binding]; metal-binding site 247156012432 dimer interface [polypeptide binding]; other site 247156012433 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 247156012434 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 247156012435 catalytic residues [active] 247156012436 TIGR03086 family protein; Region: TIGR03086 247156012437 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 247156012438 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 247156012439 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 247156012440 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 247156012441 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 247156012442 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 247156012443 cystathionine gamma-synthase; Provisional; Region: PRK07811 247156012444 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 247156012445 homodimer interface [polypeptide binding]; other site 247156012446 substrate-cofactor binding pocket; other site 247156012447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156012448 catalytic residue [active] 247156012449 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156012450 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156012451 active site 247156012452 Domain of unknown function (DUF385); Region: DUF385; pfam04075 247156012453 Conserved TM helix; Region: TM_helix; pfam05552 247156012454 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 247156012455 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 247156012456 dimer interface [polypeptide binding]; other site 247156012457 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156012458 catalytic residue [active] 247156012459 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 247156012460 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 247156012461 active site 247156012462 catalytic triad [active] 247156012463 oxyanion hole [active] 247156012464 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 247156012465 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 247156012466 dimer interface [polypeptide binding]; other site 247156012467 active site 247156012468 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 247156012469 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 247156012470 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 247156012471 Bax inhibitor 1 like; Region: BaxI_1; cl17691 247156012472 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 247156012473 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156012474 S-adenosylmethionine binding site [chemical binding]; other site 247156012475 Transcriptional regulators [Transcription]; Region: FadR; COG2186 247156012476 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 247156012477 DNA-binding site [nucleotide binding]; DNA binding site 247156012478 FCD domain; Region: FCD; pfam07729 247156012479 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 247156012480 Beta-lactamase; Region: Beta-lactamase; pfam00144 247156012481 Beta-lactamase; Region: Beta-lactamase; pfam00144 247156012482 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 247156012483 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 247156012484 Domain of unknown function (DUF385); Region: DUF385; pfam04075 247156012485 amino acid transporter; Region: 2A0306; TIGR00909 247156012486 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 247156012487 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 247156012488 POT family; Region: PTR2; cl17359 247156012489 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 247156012490 hydrophobic ligand binding site; other site 247156012491 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 247156012492 putative methyltransferase; Provisional; Region: PRK14967 247156012493 S-adenosylmethionine binding site [chemical binding]; other site 247156012494 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 247156012495 exopolyphosphatase; Region: exo_poly_only; TIGR03706 247156012496 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 247156012497 Uncharacterized conserved protein [Function unknown]; Region: COG1507 247156012498 enolase; Provisional; Region: eno; PRK00077 247156012499 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 247156012500 dimer interface [polypeptide binding]; other site 247156012501 metal binding site [ion binding]; metal-binding site 247156012502 substrate binding pocket [chemical binding]; other site 247156012503 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 247156012504 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 247156012505 N-acetyl-D-glucosamine binding site [chemical binding]; other site 247156012506 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 247156012507 substrate binding pocket [chemical binding]; other site 247156012508 active site 247156012509 iron coordination sites [ion binding]; other site 247156012510 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 247156012511 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 247156012512 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 247156012513 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842 247156012514 dimer interface [polypeptide binding]; other site 247156012515 active site 247156012516 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 247156012517 catalytic residues [active] 247156012518 substrate binding site [chemical binding]; other site 247156012519 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 247156012520 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 247156012521 dimer interface [polypeptide binding]; other site 247156012522 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156012523 catalytic residue [active] 247156012524 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 247156012525 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 247156012526 cation binding site [ion binding]; other site 247156012527 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 247156012528 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 247156012529 putative metal binding site [ion binding]; other site 247156012530 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 247156012531 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 247156012532 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 247156012533 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 247156012534 active site 247156012535 metal binding site [ion binding]; metal-binding site 247156012536 hexamer interface [polypeptide binding]; other site 247156012537 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 247156012538 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 247156012539 homodimer interface [polypeptide binding]; other site 247156012540 metal binding site [ion binding]; metal-binding site 247156012541 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 247156012542 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 247156012543 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 247156012544 ATP binding site [chemical binding]; other site 247156012545 putative Mg++ binding site [ion binding]; other site 247156012546 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 247156012547 nucleotide binding region [chemical binding]; other site 247156012548 ATP-binding site [chemical binding]; other site 247156012549 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 247156012550 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156012551 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156012552 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156012553 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156012554 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 247156012555 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 247156012556 Substrate binding site; other site 247156012557 Mg++ binding site; other site 247156012558 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 247156012559 active site 247156012560 substrate binding site [chemical binding]; other site 247156012561 CoA binding site [chemical binding]; other site 247156012562 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 247156012563 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 247156012564 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 247156012565 active site 247156012566 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 247156012567 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 247156012568 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 247156012569 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 247156012570 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 247156012571 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 247156012572 putative active site [active] 247156012573 putative dimer interface [polypeptide binding]; other site 247156012574 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 247156012575 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 247156012576 ergothioneine biosynthesis glutamate--cysteine ligase EgtA; Region: EgtA_Cys_ligase; TIGR03444 247156012577 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 247156012578 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 247156012579 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 247156012580 catalytic residue [active] 247156012581 ribonuclease Z; Reviewed; Region: PRK00055 247156012582 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 247156012583 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 247156012584 acyl-activating enzyme (AAE) consensus motif; other site 247156012585 active site 247156012586 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 247156012587 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 247156012588 putative active site [active] 247156012589 catalytic residue [active] 247156012590 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 247156012591 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 247156012592 5S rRNA interface [nucleotide binding]; other site 247156012593 CTC domain interface [polypeptide binding]; other site 247156012594 L16 interface [polypeptide binding]; other site 247156012595 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 247156012596 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 247156012597 G1 box; other site 247156012598 putative GEF interaction site [polypeptide binding]; other site 247156012599 GTP/Mg2+ binding site [chemical binding]; other site 247156012600 Switch I region; other site 247156012601 G2 box; other site 247156012602 G3 box; other site 247156012603 Switch II region; other site 247156012604 G4 box; other site 247156012605 G5 box; other site 247156012606 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 247156012607 SnoaL-like domain; Region: SnoaL_4; pfam13577 247156012608 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 247156012609 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 247156012610 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 247156012611 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 247156012612 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156012613 Walker A/P-loop; other site 247156012614 ATP binding site [chemical binding]; other site 247156012615 Q-loop/lid; other site 247156012616 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 247156012617 ABC transporter; Region: ABC_tran_2; pfam12848 247156012618 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 247156012619 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 247156012620 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 247156012621 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 247156012622 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 247156012623 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 247156012624 Domain of unknown function (DUF348); Region: DUF348; pfam03990 247156012625 Domain of unknown function (DUF348); Region: DUF348; pfam03990 247156012626 G5 domain; Region: G5; pfam07501 247156012627 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 247156012628 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 247156012629 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 247156012630 active site 247156012631 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 247156012632 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 247156012633 active site 247156012634 HIGH motif; other site 247156012635 KMSKS motif; other site 247156012636 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 247156012637 tRNA binding surface [nucleotide binding]; other site 247156012638 anticodon binding site; other site 247156012639 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 247156012640 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 247156012641 tetramer interface [polypeptide binding]; other site 247156012642 active site 247156012643 Mg2+/Mn2+ binding site [ion binding]; other site 247156012644 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 247156012645 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 247156012646 DNA binding residues [nucleotide binding] 247156012647 dimer interface [polypeptide binding]; other site 247156012648 [2Fe-2S] cluster binding site [ion binding]; other site 247156012649 arginine deiminase; Provisional; Region: PRK01388 247156012650 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 247156012651 DNA-binding site [nucleotide binding]; DNA binding site 247156012652 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 247156012653 Predicted methyltransferases [General function prediction only]; Region: COG0313 247156012654 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 247156012655 putative SAM binding site [chemical binding]; other site 247156012656 putative homodimer interface [polypeptide binding]; other site 247156012657 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 247156012658 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 247156012659 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 247156012660 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 247156012661 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 247156012662 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 247156012663 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 247156012664 metal binding site [ion binding]; metal-binding site 247156012665 active site 247156012666 I-site; other site 247156012667 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 247156012668 hypothetical protein; Provisional; Region: PRK07877 247156012669 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 247156012670 ATP binding site [chemical binding]; other site 247156012671 substrate interface [chemical binding]; other site 247156012672 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 247156012673 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 247156012674 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 247156012675 BCCT family transporter; Region: BCCT; pfam02028 247156012676 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 247156012677 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 247156012678 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156012679 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156012680 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 247156012681 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 247156012682 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 247156012683 Walker A/P-loop; other site 247156012684 ATP binding site [chemical binding]; other site 247156012685 Q-loop/lid; other site 247156012686 ABC transporter signature motif; other site 247156012687 Walker B; other site 247156012688 D-loop; other site 247156012689 H-loop/switch region; other site 247156012690 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 247156012691 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 247156012692 malonyl-CoA binding site [chemical binding]; other site 247156012693 dimer interface [polypeptide binding]; other site 247156012694 active site 247156012695 product binding site; other site 247156012696 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173 247156012697 Fatty acid desaturase; Region: FA_desaturase; pfam00487 247156012698 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 247156012699 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 247156012700 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 247156012701 Serine hydrolase (FSH1); Region: FSH1; pfam03959 247156012702 adenylate kinase; Region: adk; TIGR01351 247156012703 AAA domain; Region: AAA_17; cl17253 247156012704 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 247156012705 SynChlorMet cassette radical SAM/SPASM protein ScmF; Region: SCM_rSAM_ScmF; TIGR04251 247156012706 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683 247156012707 nudix motif; other site 247156012708 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 247156012709 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 247156012710 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 247156012711 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 247156012712 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 247156012713 dimer interface [polypeptide binding]; other site 247156012714 putative functional site; other site 247156012715 putative MPT binding site; other site 247156012716 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 247156012717 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 247156012718 active site 247156012719 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 247156012720 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331 247156012721 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 247156012722 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 247156012723 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 247156012724 MspA; Region: MspA; pfam09203 247156012725 MspA; Region: MspA; pfam09203 247156012726 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 247156012727 MPT binding site; other site 247156012728 trimer interface [polypeptide binding]; other site 247156012729 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 247156012730 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 247156012731 PDZ domain; Region: PDZ_2; pfam13180 247156012732 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 247156012733 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 247156012734 dimerization interface [polypeptide binding]; other site 247156012735 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 247156012736 dimer interface [polypeptide binding]; other site 247156012737 phosphorylation site [posttranslational modification] 247156012738 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 247156012739 ATP binding site [chemical binding]; other site 247156012740 Mg2+ binding site [ion binding]; other site 247156012741 G-X-G motif; other site 247156012742 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 247156012743 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 247156012744 active site 247156012745 phosphorylation site [posttranslational modification] 247156012746 intermolecular recognition site; other site 247156012747 dimerization interface [polypeptide binding]; other site 247156012748 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 247156012749 DNA binding site [nucleotide binding] 247156012750 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 247156012751 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 247156012752 ATP binding site [chemical binding]; other site 247156012753 Mg2+ binding site [ion binding]; other site 247156012754 G-X-G motif; other site 247156012755 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 247156012756 Protein of unknown function (DUF742); Region: DUF742; pfam05331 247156012757 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 247156012758 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 247156012759 G1 box; other site 247156012760 GTP/Mg2+ binding site [chemical binding]; other site 247156012761 G2 box; other site 247156012762 Switch I region; other site 247156012763 G3 box; other site 247156012764 Switch II region; other site 247156012765 G4 box; other site 247156012766 G5 box; other site 247156012767 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 247156012768 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 247156012769 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 247156012770 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 247156012771 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 247156012772 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 247156012773 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 247156012774 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 247156012775 30S ribosomal protein S18; Provisional; Region: PRK13401 247156012776 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 247156012777 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 247156012778 dimer interface [polypeptide binding]; other site 247156012779 active site 247156012780 CoA binding pocket [chemical binding]; other site 247156012781 Pseudomonas avirulence D protein (AvrD); Region: AvrD; pfam05655 247156012782 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156012783 Major Facilitator Superfamily; Region: MFS_1; pfam07690 247156012784 putative substrate translocation pore; other site 247156012785 AAA domain; Region: AAA_28; pfam13521 247156012786 Bulb-type mannose-specific lectin; Region: B_lectin; smart00108 247156012787 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 247156012788 dimerization interface [polypeptide binding]; other site 247156012789 mannose binding site [chemical binding]; other site 247156012790 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 247156012791 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 247156012792 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 247156012793 purine monophosphate binding site [chemical binding]; other site 247156012794 dimer interface [polypeptide binding]; other site 247156012795 putative catalytic residues [active] 247156012796 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 247156012797 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 247156012798 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 247156012799 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 247156012800 active site 247156012801 substrate binding site [chemical binding]; other site 247156012802 cosubstrate binding site; other site 247156012803 catalytic site [active] 247156012804 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 247156012805 CoA binding domain; Region: CoA_binding; smart00881 247156012806 CoA-ligase; Region: Ligase_CoA; pfam00549 247156012807 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 247156012808 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 247156012809 CoA-ligase; Region: Ligase_CoA; pfam00549 247156012810 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 247156012811 Peptidase family M23; Region: Peptidase_M23; pfam01551 247156012812 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 247156012813 hydrophobic ligand binding site; other site 247156012814 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156012815 TIGR01777 family protein; Region: yfcH 247156012816 NAD(P) binding site [chemical binding]; other site 247156012817 active site 247156012818 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 247156012819 Part of AAA domain; Region: AAA_19; pfam13245 247156012820 Family description; Region: UvrD_C_2; pfam13538 247156012821 hypothetical protein; Provisional; Region: PRK07857 247156012822 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 247156012823 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 247156012824 tetramerization interface [polypeptide binding]; other site 247156012825 NAD(P) binding site [chemical binding]; other site 247156012826 catalytic residues [active] 247156012827 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 247156012828 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 247156012829 active site 247156012830 dimer interface [polypeptide binding]; other site 247156012831 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 247156012832 dimer interface [polypeptide binding]; other site 247156012833 active site 247156012834 Ion channel; Region: Ion_trans_2; pfam07885 247156012835 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 247156012836 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 247156012837 active site 247156012838 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 247156012839 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156012840 non-specific DNA binding site [nucleotide binding]; other site 247156012841 salt bridge; other site 247156012842 sequence-specific DNA binding site [nucleotide binding]; other site 247156012843 Domain of unknown function (DUF955); Region: DUF955; cl01076 247156012844 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 247156012845 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 247156012846 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 247156012847 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 247156012848 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 247156012849 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156012850 active site 247156012851 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156012852 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 247156012853 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 247156012854 substrate binding site [chemical binding]; other site 247156012855 oxyanion hole (OAH) forming residues; other site 247156012856 trimer interface [polypeptide binding]; other site 247156012857 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 247156012858 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 247156012859 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 247156012860 DNA-binding site [nucleotide binding]; DNA binding site 247156012861 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 247156012862 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156012863 homodimer interface [polypeptide binding]; other site 247156012864 catalytic residue [active] 247156012865 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 247156012866 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 247156012867 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 247156012868 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 247156012869 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 247156012870 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 247156012871 substrate binding pocket [chemical binding]; other site 247156012872 catalytic triad [active] 247156012873 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 247156012874 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 247156012875 putative DNA binding site [nucleotide binding]; other site 247156012876 catalytic residue [active] 247156012877 putative H2TH interface [polypeptide binding]; other site 247156012878 putative catalytic residues [active] 247156012879 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 247156012880 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 247156012881 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 247156012882 active site 247156012883 SAM binding site [chemical binding]; other site 247156012884 homodimer interface [polypeptide binding]; other site 247156012885 thymidylate synthase; Reviewed; Region: thyA; PRK01827 247156012886 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 247156012887 dimerization interface [polypeptide binding]; other site 247156012888 active site 247156012889 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 247156012890 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 247156012891 folate binding site [chemical binding]; other site 247156012892 NADP+ binding site [chemical binding]; other site 247156012893 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 247156012894 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 247156012895 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 247156012896 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 247156012897 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 247156012898 putative metal binding site [ion binding]; other site 247156012899 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 247156012900 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 247156012901 putative metal binding site [ion binding]; other site 247156012902 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156012903 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156012904 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 247156012905 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 247156012906 putative catalytic residues [active] 247156012907 metallochaperone-like domain; Region: TRASH; smart00746 247156012908 Condensation domain; Region: Condensation; pfam00668 247156012909 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156012910 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 247156012911 acyl-activating enzyme (AAE) consensus motif; other site 247156012912 AMP binding site [chemical binding]; other site 247156012913 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156012914 Condensation domain; Region: Condensation; pfam00668 247156012915 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 247156012916 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 247156012917 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156012918 acyl-activating enzyme (AAE) consensus motif; other site 247156012919 AMP binding site [chemical binding]; other site 247156012920 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156012921 Condensation domain; Region: Condensation; pfam00668 247156012922 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 247156012923 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 247156012924 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156012925 acyl-activating enzyme (AAE) consensus motif; other site 247156012926 AMP binding site [chemical binding]; other site 247156012927 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156012928 Condensation domain; Region: Condensation; pfam00668 247156012929 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 247156012930 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 247156012931 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156012932 acyl-activating enzyme (AAE) consensus motif; other site 247156012933 AMP binding site [chemical binding]; other site 247156012934 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156012935 peptide synthase; Provisional; Region: PRK12467 247156012936 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 247156012937 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156012938 acyl-activating enzyme (AAE) consensus motif; other site 247156012939 AMP binding site [chemical binding]; other site 247156012940 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156012941 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 247156012942 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156012943 acyl-activating enzyme (AAE) consensus motif; other site 247156012944 AMP binding site [chemical binding]; other site 247156012945 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156012946 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 247156012947 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156012948 acyl-activating enzyme (AAE) consensus motif; other site 247156012949 AMP binding site [chemical binding]; other site 247156012950 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156012951 Condensation domain; Region: Condensation; pfam00668 247156012952 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 247156012953 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 247156012954 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156012955 acyl-activating enzyme (AAE) consensus motif; other site 247156012956 AMP binding site [chemical binding]; other site 247156012957 Condensation domain; Region: Condensation; pfam00668 247156012958 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 247156012959 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 247156012960 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156012961 acyl-activating enzyme (AAE) consensus motif; other site 247156012962 AMP binding site [chemical binding]; other site 247156012963 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156012964 Condensation domain; Region: Condensation; pfam00668 247156012965 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 247156012966 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 247156012967 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156012968 acyl-activating enzyme (AAE) consensus motif; other site 247156012969 AMP binding site [chemical binding]; other site 247156012970 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156012971 Condensation domain; Region: Condensation; pfam00668 247156012972 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 247156012973 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 247156012974 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156012975 acyl-activating enzyme (AAE) consensus motif; other site 247156012976 AMP binding site [chemical binding]; other site 247156012977 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156012978 Condensation domain; Region: Condensation; pfam00668 247156012979 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 247156012980 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 247156012981 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156012982 acyl-activating enzyme (AAE) consensus motif; other site 247156012983 AMP binding site [chemical binding]; other site 247156012984 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156012985 Condensation domain; Region: Condensation; pfam00668 247156012986 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 247156012987 Condensation domain; Region: Condensation; pfam00668 247156012988 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 247156012989 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 247156012990 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 247156012991 active site 247156012992 SAM binding site [chemical binding]; other site 247156012993 homodimer interface [polypeptide binding]; other site 247156012994 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156012995 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156012996 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 247156012997 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 247156012998 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 247156012999 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 247156013000 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 247156013001 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 247156013002 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 247156013003 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 247156013004 carboxyltransferase (CT) interaction site; other site 247156013005 biotinylation site [posttranslational modification]; other site 247156013006 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156013007 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156013008 active site 247156013009 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 247156013010 putative active site [active] 247156013011 putative catalytic site [active] 247156013012 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 247156013013 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 247156013014 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 247156013015 acyl-activating enzyme (AAE) consensus motif; other site 247156013016 putative AMP binding site [chemical binding]; other site 247156013017 putative active site [active] 247156013018 putative CoA binding site [chemical binding]; other site 247156013019 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 247156013020 conserved cys residue [active] 247156013021 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156013022 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156013023 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156013024 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156013025 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156013026 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156013027 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156013028 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 247156013029 mce related protein; Region: MCE; pfam02470 247156013030 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 247156013031 mce related protein; Region: MCE; pfam02470 247156013032 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 247156013033 mce related protein; Region: MCE; pfam02470 247156013034 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 247156013035 mce related protein; Region: MCE; pfam02470 247156013036 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 247156013037 mce related protein; Region: MCE; pfam02470 247156013038 mce related protein; Region: MCE; pfam02470 247156013039 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 247156013040 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 247156013041 Permease; Region: Permease; pfam02405 247156013042 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 247156013043 Permease; Region: Permease; pfam02405 247156013044 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 247156013045 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 247156013046 putative hydrophobic ligand binding site [chemical binding]; other site 247156013047 protein interface [polypeptide binding]; other site 247156013048 gate; other site 247156013049 hypothetical protein; Provisional; Region: PRK08266 247156013050 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 247156013051 PYR/PP interface [polypeptide binding]; other site 247156013052 dimer interface [polypeptide binding]; other site 247156013053 TPP binding site [chemical binding]; other site 247156013054 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 247156013055 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 247156013056 TPP-binding site [chemical binding]; other site 247156013057 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 247156013058 N-acetyl-D-glucosamine binding site [chemical binding]; other site 247156013059 catalytic residue [active] 247156013060 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 247156013061 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156013062 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 247156013063 acyl-activating enzyme (AAE) consensus motif; other site 247156013064 AMP binding site [chemical binding]; other site 247156013065 Condensation domain; Region: Condensation; pfam00668 247156013066 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 247156013067 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 247156013068 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156013069 acyl-activating enzyme (AAE) consensus motif; other site 247156013070 AMP binding site [chemical binding]; other site 247156013071 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156013072 Condensation domain; Region: Condensation; pfam00668 247156013073 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 247156013074 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 247156013075 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156013076 acyl-activating enzyme (AAE) consensus motif; other site 247156013077 AMP binding site [chemical binding]; other site 247156013078 Condensation domain; Region: Condensation; pfam00668 247156013079 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 247156013080 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 247156013081 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156013082 acyl-activating enzyme (AAE) consensus motif; other site 247156013083 AMP binding site [chemical binding]; other site 247156013084 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156013085 Condensation domain; Region: Condensation; pfam00668 247156013086 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 247156013087 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 247156013088 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156013089 acyl-activating enzyme (AAE) consensus motif; other site 247156013090 AMP binding site [chemical binding]; other site 247156013091 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156013092 Condensation domain; Region: Condensation; pfam00668 247156013093 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 247156013094 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 247156013095 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156013096 acyl-activating enzyme (AAE) consensus motif; other site 247156013097 AMP binding site [chemical binding]; other site 247156013098 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156013099 Condensation domain; Region: Condensation; pfam00668 247156013100 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 247156013101 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 247156013102 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156013103 acyl-activating enzyme (AAE) consensus motif; other site 247156013104 AMP binding site [chemical binding]; other site 247156013105 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156013106 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 247156013107 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 247156013108 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156013109 acyl-activating enzyme (AAE) consensus motif; other site 247156013110 AMP binding site [chemical binding]; other site 247156013111 Condensation domain; Region: Condensation; pfam00668 247156013112 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156013113 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 247156013114 acyl-activating enzyme (AAE) consensus motif; other site 247156013115 AMP binding site [chemical binding]; other site 247156013116 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156013117 Condensation domain; Region: Condensation; pfam00668 247156013118 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 247156013119 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156013120 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 247156013121 acyl-activating enzyme (AAE) consensus motif; other site 247156013122 AMP binding site [chemical binding]; other site 247156013123 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156013124 Condensation domain; Region: Condensation; pfam00668 247156013125 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 247156013126 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 247156013127 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156013128 acyl-activating enzyme (AAE) consensus motif; other site 247156013129 AMP binding site [chemical binding]; other site 247156013130 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 247156013131 Condensation domain; Region: Condensation; pfam00668 247156013132 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 247156013133 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156013134 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 247156013135 acyl-activating enzyme (AAE) consensus motif; other site 247156013136 AMP binding site [chemical binding]; other site 247156013137 Condensation domain; Region: Condensation; pfam00668 247156013138 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 247156013139 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 247156013140 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 247156013141 acyl-activating enzyme (AAE) consensus motif; other site 247156013142 AMP binding site [chemical binding]; other site 247156013143 Condensation domain; Region: Condensation; pfam00668 247156013144 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 247156013145 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 247156013146 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 247156013147 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 247156013148 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 247156013149 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 247156013150 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 247156013151 active site 247156013152 tetracycline repressor protein TetR; Provisional; Region: PRK13756 247156013153 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156013154 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 247156013155 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 247156013156 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 247156013157 FAD binding pocket [chemical binding]; other site 247156013158 FAD binding motif [chemical binding]; other site 247156013159 phosphate binding motif [ion binding]; other site 247156013160 beta-alpha-beta structure motif; other site 247156013161 NAD(p) ribose binding residues [chemical binding]; other site 247156013162 NAD binding pocket [chemical binding]; other site 247156013163 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 247156013164 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 247156013165 catalytic loop [active] 247156013166 iron binding site [ion binding]; other site 247156013167 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 247156013168 A new structural DNA glycosylase; Region: AlkD_like; cd06561 247156013169 active site 247156013170 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 247156013171 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 247156013172 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 247156013173 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156013174 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156013175 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 247156013176 TAP-like protein; Region: Abhydrolase_4; pfam08386 247156013177 elongation factor Tu; Reviewed; Region: PRK00049 247156013178 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 247156013179 G1 box; other site 247156013180 GEF interaction site [polypeptide binding]; other site 247156013181 GTP/Mg2+ binding site [chemical binding]; other site 247156013182 Switch I region; other site 247156013183 G2 box; other site 247156013184 G3 box; other site 247156013185 Switch II region; other site 247156013186 G4 box; other site 247156013187 G5 box; other site 247156013188 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 247156013189 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 247156013190 Antibiotic Binding Site [chemical binding]; other site 247156013191 elongation factor G; Reviewed; Region: PRK00007 247156013192 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 247156013193 G1 box; other site 247156013194 putative GEF interaction site [polypeptide binding]; other site 247156013195 GTP/Mg2+ binding site [chemical binding]; other site 247156013196 Switch I region; other site 247156013197 G2 box; other site 247156013198 G3 box; other site 247156013199 Switch II region; other site 247156013200 G4 box; other site 247156013201 G5 box; other site 247156013202 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 247156013203 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 247156013204 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 247156013205 30S ribosomal protein S7; Validated; Region: PRK05302 247156013206 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 247156013207 S17 interaction site [polypeptide binding]; other site 247156013208 S8 interaction site; other site 247156013209 16S rRNA interaction site [nucleotide binding]; other site 247156013210 streptomycin interaction site [chemical binding]; other site 247156013211 23S rRNA interaction site [nucleotide binding]; other site 247156013212 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 247156013213 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 247156013214 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 247156013215 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 247156013216 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 247156013217 dimer interface [polypeptide binding]; other site 247156013218 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 247156013219 active site 247156013220 Fe binding site [ion binding]; other site 247156013221 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 247156013222 putative DNA binding site [nucleotide binding]; other site 247156013223 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 247156013224 putative Zn2+ binding site [ion binding]; other site 247156013225 AsnC family; Region: AsnC_trans_reg; pfam01037 247156013226 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 247156013227 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 247156013228 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 247156013229 NAD(P) binding site [chemical binding]; other site 247156013230 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 247156013231 N-acetyl-D-glucosamine binding site [chemical binding]; other site 247156013232 catalytic residue [active] 247156013233 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 247156013234 active site 247156013235 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 247156013236 active site 2 [active] 247156013237 Ferredoxin [Energy production and conversion]; Region: COG1146 247156013238 4Fe-4S binding domain; Region: Fer4; pfam00037 247156013239 ferredoxin-NADP+ reductase; Region: PLN02852 247156013240 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 247156013241 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 247156013242 catalytic core [active] 247156013243 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 247156013244 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 247156013245 Uncharacterized conserved protein [Function unknown]; Region: COG2128 247156013246 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 247156013247 Predicted acetyltransferase [General function prediction only]; Region: COG2388 247156013248 Pirin-related protein [General function prediction only]; Region: COG1741 247156013249 Pirin; Region: Pirin; pfam02678 247156013250 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 247156013251 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 247156013252 putative hydrophobic ligand binding site [chemical binding]; other site 247156013253 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 247156013254 putative DNA binding site [nucleotide binding]; other site 247156013255 putative Zn2+ binding site [ion binding]; other site 247156013256 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 247156013257 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 247156013258 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 247156013259 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 247156013260 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 247156013261 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 247156013262 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 247156013263 G-loop; other site 247156013264 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 247156013265 DNA binding site [nucleotide binding] 247156013266 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 247156013267 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 247156013268 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 247156013269 RPB12 interaction site [polypeptide binding]; other site 247156013270 RPB1 interaction site [polypeptide binding]; other site 247156013271 RPB10 interaction site [polypeptide binding]; other site 247156013272 RPB11 interaction site [polypeptide binding]; other site 247156013273 RPB3 interaction site [polypeptide binding]; other site 247156013274 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 247156013275 mce related protein; Region: MCE; pfam02470 247156013276 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 247156013277 mce related protein; Region: MCE; pfam02470 247156013278 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 247156013279 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 247156013280 mce related protein; Region: MCE; pfam02470 247156013281 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 247156013282 mce related protein; Region: MCE; pfam02470 247156013283 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 247156013284 mce related protein; Region: MCE; pfam02470 247156013285 mce related protein; Region: MCE; pfam02470 247156013286 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 247156013287 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 247156013288 Permease; Region: Permease; pfam02405 247156013289 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 247156013290 Permease; Region: Permease; pfam02405 247156013291 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 247156013292 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 247156013293 Walker A/P-loop; other site 247156013294 ATP binding site [chemical binding]; other site 247156013295 Q-loop/lid; other site 247156013296 ABC transporter signature motif; other site 247156013297 Walker B; other site 247156013298 D-loop; other site 247156013299 H-loop/switch region; other site 247156013300 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 247156013301 core dimer interface [polypeptide binding]; other site 247156013302 peripheral dimer interface [polypeptide binding]; other site 247156013303 L10 interface [polypeptide binding]; other site 247156013304 L11 interface [polypeptide binding]; other site 247156013305 putative EF-Tu interaction site [polypeptide binding]; other site 247156013306 putative EF-G interaction site [polypeptide binding]; other site 247156013307 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 247156013308 23S rRNA interface [nucleotide binding]; other site 247156013309 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 247156013310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156013311 Major Facilitator Superfamily; Region: MFS_1; pfam07690 247156013312 putative substrate translocation pore; other site 247156013313 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156013314 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 247156013315 mRNA/rRNA interface [nucleotide binding]; other site 247156013316 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 247156013317 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 247156013318 23S rRNA interface [nucleotide binding]; other site 247156013319 L7/L12 interface [polypeptide binding]; other site 247156013320 putative thiostrepton binding site; other site 247156013321 L25 interface [polypeptide binding]; other site 247156013322 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 247156013323 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 247156013324 putative homodimer interface [polypeptide binding]; other site 247156013325 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 247156013326 heterodimer interface [polypeptide binding]; other site 247156013327 homodimer interface [polypeptide binding]; other site 247156013328 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 247156013329 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 247156013330 active site 247156013331 catalytic site [active] 247156013332 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 247156013333 active site 247156013334 catalytic site [active] 247156013335 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 247156013336 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 247156013337 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 247156013338 heat shock protein HtpX; Provisional; Region: PRK03072 247156013339 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 247156013340 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 247156013341 substrate binding pocket [chemical binding]; other site 247156013342 chain length determination region; other site 247156013343 substrate-Mg2+ binding site; other site 247156013344 catalytic residues [active] 247156013345 aspartate-rich region 1; other site 247156013346 active site lid residues [active] 247156013347 aspartate-rich region 2; other site 247156013348 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 247156013349 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 247156013350 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 247156013351 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 247156013352 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 247156013353 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 247156013354 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 247156013355 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 247156013356 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 247156013357 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 247156013358 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 247156013359 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156013360 S-adenosylmethionine binding site [chemical binding]; other site 247156013361 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 247156013362 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 247156013363 [4Fe-4S] binding site [ion binding]; other site 247156013364 molybdopterin cofactor binding site; other site 247156013365 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 247156013366 molybdopterin cofactor binding site; other site 247156013367 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 247156013368 Flavodoxin; Region: Flavodoxin_1; pfam00258 247156013369 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 247156013370 FAD binding pocket [chemical binding]; other site 247156013371 FAD binding motif [chemical binding]; other site 247156013372 catalytic residues [active] 247156013373 NAD binding pocket [chemical binding]; other site 247156013374 phosphate binding motif [ion binding]; other site 247156013375 beta-alpha-beta structure motif; other site 247156013376 TIGR03086 family protein; Region: TIGR03086 247156013377 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 247156013378 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 247156013379 dimer interface [polypeptide binding]; other site 247156013380 tetramer interface [polypeptide binding]; other site 247156013381 PYR/PP interface [polypeptide binding]; other site 247156013382 TPP binding site [chemical binding]; other site 247156013383 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 247156013384 TPP-binding site; other site 247156013385 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 247156013386 putative dimer interface [polypeptide binding]; other site 247156013387 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 247156013388 Predicted transcriptional regulator [Transcription]; Region: COG2378 247156013389 HTH domain; Region: HTH_11; pfam08279 247156013390 WYL domain; Region: WYL; pfam13280 247156013391 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 247156013392 CoenzymeA binding site [chemical binding]; other site 247156013393 subunit interaction site [polypeptide binding]; other site 247156013394 PHB binding site; other site 247156013395 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 247156013396 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 247156013397 substrate binding site [chemical binding]; other site 247156013398 oxyanion hole (OAH) forming residues; other site 247156013399 trimer interface [polypeptide binding]; other site 247156013400 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156013401 non-specific DNA binding site [nucleotide binding]; other site 247156013402 salt bridge; other site 247156013403 sequence-specific DNA binding site [nucleotide binding]; other site 247156013404 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 247156013405 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 247156013406 active site 247156013407 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 247156013408 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 247156013409 acyl-activating enzyme (AAE) consensus motif; other site 247156013410 AMP binding site [chemical binding]; other site 247156013411 active site 247156013412 CoA binding site [chemical binding]; other site 247156013413 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156013414 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 247156013415 Walker A/P-loop; other site 247156013416 ATP binding site [chemical binding]; other site 247156013417 Q-loop/lid; other site 247156013418 ABC transporter signature motif; other site 247156013419 Walker B; other site 247156013420 D-loop; other site 247156013421 H-loop/switch region; other site 247156013422 ABC-2 type transporter; Region: ABC2_membrane; cl17235 247156013423 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 247156013424 Bacterial transcriptional activator domain; Region: BTAD; smart01043 247156013425 AAA ATPase domain; Region: AAA_16; pfam13191 247156013426 Predicted ATPase [General function prediction only]; Region: COG3903 247156013427 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 247156013428 putative hydrophobic ligand binding site [chemical binding]; other site 247156013429 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 247156013430 UbiA prenyltransferase family; Region: UbiA; pfam01040 247156013431 Membrane protein of unknown function; Region: DUF360; cl00850 247156013432 Clp amino terminal domain; Region: Clp_N; pfam02861 247156013433 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 247156013434 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 247156013435 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 247156013436 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 247156013437 catalytic residue [active] 247156013438 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 247156013439 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 247156013440 DNA binding residues [nucleotide binding] 247156013441 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 247156013442 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 247156013443 ResB-like family; Region: ResB; pfam05140 247156013444 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 247156013445 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 247156013446 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 247156013447 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 247156013448 catalytic residues [active] 247156013449 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 247156013450 catalytic core [active] 247156013451 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 247156013452 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 247156013453 inhibitor-cofactor binding pocket; inhibition site 247156013454 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156013455 catalytic residue [active] 247156013456 3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06035 247156013457 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 247156013458 dimer interface [polypeptide binding]; other site 247156013459 active site 247156013460 Schiff base residues; other site 247156013461 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 247156013462 active site 247156013463 homodimer interface [polypeptide binding]; other site 247156013464 SAM binding site [chemical binding]; other site 247156013465 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 247156013466 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 247156013467 active site 247156013468 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 247156013469 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 247156013470 domain interfaces; other site 247156013471 active site 247156013472 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 247156013473 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 247156013474 tRNA; other site 247156013475 putative tRNA binding site [nucleotide binding]; other site 247156013476 putative NADP binding site [chemical binding]; other site 247156013477 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 247156013478 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 247156013479 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 247156013480 CoA binding domain; Region: CoA_binding; smart00881 247156013481 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 247156013482 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 247156013483 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 247156013484 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 247156013485 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 247156013486 putative acyl-acceptor binding pocket; other site 247156013487 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 247156013488 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156013489 NAD(P) binding site [chemical binding]; other site 247156013490 active site 247156013491 DNA binding domain, excisionase family; Region: excise; TIGR01764 247156013492 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 247156013493 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 247156013494 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 247156013495 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 247156013496 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 247156013497 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 247156013498 exopolyphosphatase; Region: exo_poly_only; TIGR03706 247156013499 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 247156013500 CARDB; Region: CARDB; pfam07705 247156013501 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 247156013502 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 247156013503 active site 247156013504 phosphorylation site [posttranslational modification] 247156013505 intermolecular recognition site; other site 247156013506 dimerization interface [polypeptide binding]; other site 247156013507 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 247156013508 DNA binding site [nucleotide binding] 247156013509 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 247156013510 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 247156013511 dimer interface [polypeptide binding]; other site 247156013512 phosphorylation site [posttranslational modification] 247156013513 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 247156013514 ATP binding site [chemical binding]; other site 247156013515 Mg2+ binding site [ion binding]; other site 247156013516 G-X-G motif; other site 247156013517 Predicted acyl esterases [General function prediction only]; Region: COG2936 247156013518 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 247156013519 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 247156013520 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 247156013521 catalytic core [active] 247156013522 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 247156013523 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 247156013524 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 247156013525 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 247156013526 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 247156013527 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 247156013528 putative ADP-binding pocket [chemical binding]; other site 247156013529 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 247156013530 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 247156013531 TAP-like protein; Region: Abhydrolase_4; pfam08386 247156013532 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 247156013533 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156013534 NAD(P) binding site [chemical binding]; other site 247156013535 active site 247156013536 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 247156013537 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 247156013538 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 247156013539 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 247156013540 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 247156013541 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 247156013542 FAD binding domain; Region: FAD_binding_4; pfam01565 247156013543 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 247156013544 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 247156013545 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 247156013546 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 247156013547 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 247156013548 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 247156013549 intersubunit interface [polypeptide binding]; other site 247156013550 catalytic residue [active] 247156013551 Predicted acetyltransferase [General function prediction only]; Region: COG3153 247156013552 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 247156013553 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 247156013554 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 247156013555 putative active site [active] 247156013556 putative substrate binding site [chemical binding]; other site 247156013557 putative cosubstrate binding site; other site 247156013558 catalytic site [active] 247156013559 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 247156013560 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 247156013561 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 247156013562 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 247156013563 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156013564 non-specific DNA binding site [nucleotide binding]; other site 247156013565 salt bridge; other site 247156013566 sequence-specific DNA binding site [nucleotide binding]; other site 247156013567 Protein of unknown function (DUF445); Region: DUF445; pfam04286 247156013568 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156013569 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156013570 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 247156013571 ABC1 family; Region: ABC1; cl17513 247156013572 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 247156013573 active site 247156013574 ATP binding site [chemical binding]; other site 247156013575 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 247156013576 Uncharacterized conserved protein [Function unknown]; Region: COG3268 247156013577 NAD(P) binding pocket [chemical binding]; other site 247156013578 EspG family; Region: ESX-1_EspG; pfam14011 247156013579 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 247156013580 LexA repressor; Validated; Region: PRK00215 247156013581 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 247156013582 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 247156013583 Catalytic site [active] 247156013584 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 247156013585 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 247156013586 hypothetical protein; Provisional; Region: PRK07236 247156013587 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 247156013588 Carboxylesterase family; Region: COesterase; pfam00135 247156013589 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 247156013590 substrate binding pocket [chemical binding]; other site 247156013591 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 247156013592 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 247156013593 catalytic residues [active] 247156013594 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 247156013595 putative active site [active] 247156013596 redox center [active] 247156013597 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 247156013598 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 247156013599 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 247156013600 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 247156013601 putative NAD(P) binding site [chemical binding]; other site 247156013602 putative substrate binding site [chemical binding]; other site 247156013603 catalytic Zn binding site [ion binding]; other site 247156013604 structural Zn binding site [ion binding]; other site 247156013605 dimer interface [polypeptide binding]; other site 247156013606 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 247156013607 Domain of unknown function DUF20; Region: UPF0118; pfam01594 247156013608 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 247156013609 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 247156013610 THF binding site; other site 247156013611 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 247156013612 substrate binding site [chemical binding]; other site 247156013613 THF binding site; other site 247156013614 zinc-binding site [ion binding]; other site 247156013615 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 247156013616 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 247156013617 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 247156013618 isocitrate lyase; Provisional; Region: PRK15063 247156013619 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 247156013620 tetramer interface [polypeptide binding]; other site 247156013621 active site 247156013622 Mg2+/Mn2+ binding site [ion binding]; other site 247156013623 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 247156013624 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 247156013625 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156013626 sequence-specific DNA binding site [nucleotide binding]; other site 247156013627 salt bridge; other site 247156013628 Uncharacterized conserved protein [Function unknown]; Region: COG1262 247156013629 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 247156013630 hypothetical protein; Provisional; Region: PRK09266 247156013631 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 247156013632 homodimer interface [polypeptide binding]; other site 247156013633 substrate-cofactor binding pocket; other site 247156013634 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156013635 catalytic residue [active] 247156013636 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 247156013637 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 247156013638 active site 247156013639 catalytic site [active] 247156013640 tetramer interface [polypeptide binding]; other site 247156013641 allantoicase; Provisional; Region: PRK13257 247156013642 Allantoicase repeat; Region: Allantoicase; pfam03561 247156013643 Allantoicase repeat; Region: Allantoicase; pfam03561 247156013644 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 247156013645 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 247156013646 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 247156013647 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 247156013648 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 247156013649 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 247156013650 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 247156013651 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 247156013652 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 247156013653 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 247156013654 active site 247156013655 urate oxidase; Region: urate_oxi; TIGR03383 247156013656 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 247156013657 active site 247156013658 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 247156013659 active site 247156013660 homotetramer interface [polypeptide binding]; other site 247156013661 OHCU decarboxylase; Region: UraD_2; TIGR03180 247156013662 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 247156013663 Ligand binding site; other site 247156013664 metal-binding site 247156013665 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 247156013666 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 247156013667 XdhC Rossmann domain; Region: XdhC_C; pfam13478 247156013668 1-phosphofructokinase; Region: pfkB; TIGR03828 247156013669 ATP binding site [chemical binding]; other site 247156013670 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 247156013671 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 247156013672 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 247156013673 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 247156013674 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 247156013675 active site 247156013676 DNA binding site [nucleotide binding] 247156013677 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 247156013678 DNA binding site [nucleotide binding] 247156013679 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 247156013680 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156013681 non-specific DNA binding site [nucleotide binding]; other site 247156013682 salt bridge; other site 247156013683 sequence-specific DNA binding site [nucleotide binding]; other site 247156013684 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 247156013685 Domain of unknown function (DUF955); Region: DUF955; pfam06114 247156013686 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 247156013687 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 247156013688 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 247156013689 putative ligand binding site [chemical binding]; other site 247156013690 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 247156013691 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 247156013692 TM-ABC transporter signature motif; other site 247156013693 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 247156013694 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 247156013695 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 247156013696 TM-ABC transporter signature motif; other site 247156013697 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 247156013698 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 247156013699 Walker A/P-loop; other site 247156013700 ATP binding site [chemical binding]; other site 247156013701 Q-loop/lid; other site 247156013702 ABC transporter signature motif; other site 247156013703 Walker B; other site 247156013704 D-loop; other site 247156013705 H-loop/switch region; other site 247156013706 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 247156013707 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 247156013708 Walker A/P-loop; other site 247156013709 ATP binding site [chemical binding]; other site 247156013710 Q-loop/lid; other site 247156013711 ABC transporter signature motif; other site 247156013712 Walker B; other site 247156013713 D-loop; other site 247156013714 H-loop/switch region; other site 247156013715 Transcriptional regulators [Transcription]; Region: FadR; COG2186 247156013716 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 247156013717 DNA-binding site [nucleotide binding]; DNA binding site 247156013718 Uncharacterized conserved protein [Function unknown]; Region: COG2128 247156013719 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 247156013720 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 247156013721 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 247156013722 putative dimer interface [polypeptide binding]; other site 247156013723 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 247156013724 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 247156013725 Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956 247156013726 NodB motif; other site 247156013727 putative active site [active] 247156013728 putative catalytic site [active] 247156013729 putative Zn binding site [ion binding]; other site 247156013730 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 247156013731 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 247156013732 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 247156013733 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 247156013734 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 247156013735 Prostaglandin dehydrogenases; Region: PGDH; cd05288 247156013736 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 247156013737 NAD(P) binding site [chemical binding]; other site 247156013738 substrate binding site [chemical binding]; other site 247156013739 dimer interface [polypeptide binding]; other site 247156013740 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 247156013741 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 247156013742 active site 247156013743 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 247156013744 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 247156013745 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 247156013746 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156013747 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156013748 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 247156013749 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 247156013750 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 247156013751 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 247156013752 ring oligomerisation interface [polypeptide binding]; other site 247156013753 ATP/Mg binding site [chemical binding]; other site 247156013754 stacking interactions; other site 247156013755 hinge regions; other site 247156013756 Clp amino terminal domain; Region: Clp_N; pfam02861 247156013757 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 247156013758 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 247156013759 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 247156013760 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 247156013761 DNA binding residues [nucleotide binding] 247156013762 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 247156013763 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 247156013764 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 247156013765 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 247156013766 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 247156013767 dimer interface [polypeptide binding]; other site 247156013768 active site 247156013769 CoA binding pocket [chemical binding]; other site 247156013770 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 247156013771 hydrophobic ligand binding site; other site 247156013772 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 247156013773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 247156013774 active site 247156013775 phosphorylation site [posttranslational modification] 247156013776 intermolecular recognition site; other site 247156013777 dimerization interface [polypeptide binding]; other site 247156013778 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 247156013779 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 247156013780 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 247156013781 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 247156013782 ligand binding site [chemical binding]; other site 247156013783 flexible hinge region; other site 247156013784 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 247156013785 ATP binding site [chemical binding]; other site 247156013786 Mg2+ binding site [ion binding]; other site 247156013787 G-X-G motif; other site 247156013788 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 247156013789 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 247156013790 Cell division protein 48 (CDC48) N-terminal domain; Region: CDC48_N; smart01073 247156013791 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 247156013792 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 247156013793 Walker A motif; other site 247156013794 ATP binding site [chemical binding]; other site 247156013795 Walker B motif; other site 247156013796 arginine finger; other site 247156013797 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 247156013798 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 247156013799 Walker A motif; other site 247156013800 ATP binding site [chemical binding]; other site 247156013801 Walker B motif; other site 247156013802 arginine finger; other site 247156013803 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 247156013804 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 247156013805 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 247156013806 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 247156013807 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 247156013808 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 247156013809 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 247156013810 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 247156013811 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 247156013812 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948 247156013813 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 247156013814 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 247156013815 active site 247156013816 carboxylate-amine ligase; Provisional; Region: PRK13517 247156013817 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 247156013818 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 247156013819 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 247156013820 E-class dimer interface [polypeptide binding]; other site 247156013821 P-class dimer interface [polypeptide binding]; other site 247156013822 active site 247156013823 Cu2+ binding site [ion binding]; other site 247156013824 Zn2+ binding site [ion binding]; other site 247156013825 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 247156013826 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 247156013827 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 247156013828 active site 247156013829 catalytic residues [active] 247156013830 metal binding site [ion binding]; metal-binding site 247156013831 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 247156013832 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 247156013833 Coenzyme A binding pocket [chemical binding]; other site 247156013834 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 247156013835 putative catalytic site [active] 247156013836 putative phosphate binding site [ion binding]; other site 247156013837 active site 247156013838 metal binding site A [ion binding]; metal-binding site 247156013839 DNA binding site [nucleotide binding] 247156013840 putative AP binding site [nucleotide binding]; other site 247156013841 putative metal binding site B [ion binding]; other site 247156013842 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 247156013843 fumarylacetoacetase; Region: PLN02856 247156013844 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 247156013845 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 247156013846 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 247156013847 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 247156013848 ATP binding site [chemical binding]; other site 247156013849 Mg2+ binding site [ion binding]; other site 247156013850 G-X-G motif; other site 247156013851 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 247156013852 Protein of unknown function (DUF742); Region: DUF742; pfam05331 247156013853 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 247156013854 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 247156013855 G2 box; other site 247156013856 Switch I region; other site 247156013857 Switch II region; other site 247156013858 G3 box; other site 247156013859 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 247156013860 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 247156013861 Cytochrome P450; Region: p450; cl12078 247156013862 OsmC-like protein; Region: OsmC; pfam02566 247156013863 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 247156013864 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 247156013865 dimer interface [polypeptide binding]; other site 247156013866 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 247156013867 ThiC-associated domain; Region: ThiC-associated; pfam13667 247156013868 ThiC family; Region: ThiC; pfam01964 247156013869 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 247156013870 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 247156013871 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 247156013872 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 247156013873 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 247156013874 dimer interface [polypeptide binding]; other site 247156013875 substrate binding site [chemical binding]; other site 247156013876 ATP binding site [chemical binding]; other site 247156013877 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156013878 S-adenosylmethionine binding site [chemical binding]; other site 247156013879 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 247156013880 Ligand binding site; other site 247156013881 Ligand binding site; other site 247156013882 Ligand binding site; other site 247156013883 Putative Catalytic site; other site 247156013884 DXD motif; other site 247156013885 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 247156013886 HipA N-terminal domain; Region: Couple_hipA; pfam13657 247156013887 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 247156013888 HipA-like N-terminal domain; Region: HipA_N; pfam07805 247156013889 HipA-like C-terminal domain; Region: HipA_C; pfam07804 247156013890 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 247156013891 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156013892 non-specific DNA binding site [nucleotide binding]; other site 247156013893 salt bridge; other site 247156013894 sequence-specific DNA binding site [nucleotide binding]; other site 247156013895 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156013896 enoyl-CoA hydratase; Provisional; Region: PRK07827 247156013897 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 247156013898 substrate binding site [chemical binding]; other site 247156013899 oxyanion hole (OAH) forming residues; other site 247156013900 trimer interface [polypeptide binding]; other site 247156013901 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156013902 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 247156013903 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 247156013904 active site 247156013905 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 247156013906 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 247156013907 ATP-grasp domain; Region: ATP-grasp_4; cl17255 247156013908 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 247156013909 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 247156013910 carboxyltransferase (CT) interaction site; other site 247156013911 biotinylation site [posttranslational modification]; other site 247156013912 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 247156013913 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 247156013914 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 247156013915 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156013916 active site 247156013917 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 247156013918 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 247156013919 cyclase homology domain; Region: CHD; cd07302 247156013920 nucleotidyl binding site; other site 247156013921 metal binding site [ion binding]; metal-binding site 247156013922 dimer interface [polypeptide binding]; other site 247156013923 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 247156013924 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 247156013925 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 247156013926 Walker A/P-loop; other site 247156013927 ATP binding site [chemical binding]; other site 247156013928 Q-loop/lid; other site 247156013929 ABC transporter signature motif; other site 247156013930 Walker B; other site 247156013931 D-loop; other site 247156013932 H-loop/switch region; other site 247156013933 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 247156013934 ThiS interaction site; other site 247156013935 putative active site [active] 247156013936 tetramer interface [polypeptide binding]; other site 247156013937 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 247156013938 thiS-thiF/thiG interaction site; other site 247156013939 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 247156013940 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 247156013941 thiamine phosphate binding site [chemical binding]; other site 247156013942 active site 247156013943 pyrophosphate binding site [ion binding]; other site 247156013944 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 247156013945 nudix motif; other site 247156013946 Protein of unknown function (DUF3729); Region: DUF3729; pfam12526 247156013947 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 247156013948 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 247156013949 substrate binding pocket [chemical binding]; other site 247156013950 membrane-bound complex binding site; other site 247156013951 hinge residues; other site 247156013952 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 247156013953 Catalytic domain of Protein Kinases; Region: PKc; cd00180 247156013954 active site 247156013955 ATP binding site [chemical binding]; other site 247156013956 substrate binding site [chemical binding]; other site 247156013957 activation loop (A-loop); other site 247156013958 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 247156013959 propionate/acetate kinase; Provisional; Region: PRK12379 247156013960 phosphate acetyltransferase; Reviewed; Region: PRK05632 247156013961 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 247156013962 DRTGG domain; Region: DRTGG; pfam07085 247156013963 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 247156013964 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 247156013965 conserved cys residue [active] 247156013966 MarR family; Region: MarR_2; pfam12802 247156013967 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 247156013968 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 247156013969 active site 247156013970 motif I; other site 247156013971 motif II; other site 247156013972 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 247156013973 motif II; other site 247156013974 Helix-turn-helix domain; Region: HTH_18; pfam12833 247156013975 RibD C-terminal domain; Region: RibD_C; cl17279 247156013976 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR8; cd08273 247156013977 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 247156013978 putative NAD(P) binding site [chemical binding]; other site 247156013979 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156013980 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156013981 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 247156013982 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 247156013983 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 247156013984 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 247156013985 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 247156013986 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 247156013987 Protein of unknown function (DUF3703); Region: DUF3703; pfam12487 247156013988 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 247156013989 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 247156013990 homodimer interface [polypeptide binding]; other site 247156013991 substrate-cofactor binding pocket; other site 247156013992 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156013993 catalytic residue [active] 247156013994 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 247156013995 active site residue [active] 247156013996 ferredoxin-NADP+ reductase; Region: PLN02852 247156013997 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 247156013998 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 247156013999 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 247156014000 active site 247156014001 Protein of unknown function (DUF456); Region: DUF456; pfam04306 247156014002 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 247156014003 CoA-transferase family III; Region: CoA_transf_3; pfam02515 247156014004 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 247156014005 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 247156014006 DNA-binding site [nucleotide binding]; DNA binding site 247156014007 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 247156014008 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156014009 homodimer interface [polypeptide binding]; other site 247156014010 catalytic residue [active] 247156014011 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 247156014012 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 247156014013 DNA binding site [nucleotide binding] 247156014014 active site 247156014015 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 247156014016 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 247156014017 DNA binding residues [nucleotide binding] 247156014018 drug binding residues [chemical binding]; other site 247156014019 dimer interface [polypeptide binding]; other site 247156014020 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 247156014021 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 247156014022 Walker A motif; other site 247156014023 ATP binding site [chemical binding]; other site 247156014024 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 247156014025 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 247156014026 DNA binding residues [nucleotide binding] 247156014027 dimerization interface [polypeptide binding]; other site 247156014028 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 247156014029 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 247156014030 GDP-binding site [chemical binding]; other site 247156014031 ACT binding site; other site 247156014032 IMP binding site; other site 247156014033 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 247156014034 Peptidase family M50; Region: Peptidase_M50; pfam02163 247156014035 active site 247156014036 putative substrate binding region [chemical binding]; other site 247156014037 Predicted membrane protein [Function unknown]; Region: COG4129 247156014038 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 247156014039 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 247156014040 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 247156014041 active site 247156014042 catalytic site [active] 247156014043 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 247156014044 active site 247156014045 catalytic site [active] 247156014046 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 247156014047 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 247156014048 DNA binding site [nucleotide binding] 247156014049 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 247156014050 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 247156014051 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 247156014052 phosphopeptide binding site; other site 247156014053 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 247156014054 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 247156014055 active site 247156014056 intersubunit interface [polypeptide binding]; other site 247156014057 zinc binding site [ion binding]; other site 247156014058 Na+ binding site [ion binding]; other site 247156014059 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 247156014060 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 247156014061 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 247156014062 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 247156014063 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 247156014064 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 247156014065 EspG family; Region: ESX-1_EspG; pfam14011 247156014066 PPE family; Region: PPE; pfam00823 247156014067 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 247156014068 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 247156014069 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 247156014070 YhhN-like protein; Region: YhhN; pfam07947 247156014071 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 247156014072 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 247156014073 dimer interface [polypeptide binding]; other site 247156014074 active site 247156014075 CoA binding pocket [chemical binding]; other site 247156014076 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 247156014077 active site 247156014078 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 247156014079 classical (c) SDRs; Region: SDR_c; cd05233 247156014080 NAD(P) binding site [chemical binding]; other site 247156014081 active site 247156014082 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 247156014083 generic binding surface I; other site 247156014084 generic binding surface II; other site 247156014085 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 247156014086 Clp amino terminal domain; Region: Clp_N; pfam02861 247156014087 Clp amino terminal domain; Region: Clp_N; pfam02861 247156014088 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 247156014089 Walker A motif; other site 247156014090 ATP binding site [chemical binding]; other site 247156014091 Walker B motif; other site 247156014092 arginine finger; other site 247156014093 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 247156014094 Walker A motif; other site 247156014095 ATP binding site [chemical binding]; other site 247156014096 Walker B motif; other site 247156014097 arginine finger; other site 247156014098 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 247156014099 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 247156014100 heme-binding site [chemical binding]; other site 247156014101 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 247156014102 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 247156014103 FAD binding pocket [chemical binding]; other site 247156014104 FAD binding motif [chemical binding]; other site 247156014105 phosphate binding motif [ion binding]; other site 247156014106 beta-alpha-beta structure motif; other site 247156014107 NAD binding pocket [chemical binding]; other site 247156014108 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 247156014109 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 247156014110 FAD binding pocket [chemical binding]; other site 247156014111 FAD binding motif [chemical binding]; other site 247156014112 phosphate binding motif [ion binding]; other site 247156014113 beta-alpha-beta structure motif; other site 247156014114 NAD binding pocket [chemical binding]; other site 247156014115 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 247156014116 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 247156014117 heme-binding site [chemical binding]; other site 247156014118 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 247156014119 FAD binding pocket [chemical binding]; other site 247156014120 FAD binding motif [chemical binding]; other site 247156014121 phosphate binding motif [ion binding]; other site 247156014122 beta-alpha-beta structure motif; other site 247156014123 NAD binding pocket [chemical binding]; other site 247156014124 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 247156014125 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 247156014126 DNA binding residues [nucleotide binding] 247156014127 putative dimer interface [polypeptide binding]; other site 247156014128 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 247156014129 HSP70 interaction site [polypeptide binding]; other site 247156014130 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 247156014131 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 247156014132 Zn binding sites [ion binding]; other site 247156014133 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 247156014134 dimer interface [polypeptide binding]; other site 247156014135 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 247156014136 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 247156014137 dimer interface [polypeptide binding]; other site 247156014138 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 247156014139 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 247156014140 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 247156014141 nucleotide binding site [chemical binding]; other site 247156014142 NEF interaction site [polypeptide binding]; other site 247156014143 SBD interface [polypeptide binding]; other site 247156014144 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 247156014145 G1 box; other site 247156014146 GTP/Mg2+ binding site [chemical binding]; other site 247156014147 G2 box; other site 247156014148 Switch I region; other site 247156014149 G3 box; other site 247156014150 Switch II region; other site 247156014151 G4 box; other site 247156014152 G5 box; other site 247156014153 Dynamin family; Region: Dynamin_N; pfam00350 247156014154 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 247156014155 G3 box; other site 247156014156 Switch II region; other site 247156014157 GTP/Mg2+ binding site [chemical binding]; other site 247156014158 G4 box; other site 247156014159 G5 box; other site 247156014160 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 247156014161 nucleotide binding site [chemical binding]; other site 247156014162 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 247156014163 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 247156014164 DNA binding residues [nucleotide binding] 247156014165 dimerization interface [polypeptide binding]; other site 247156014166 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 247156014167 NRDE protein; Region: NRDE; cl01315 247156014168 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 247156014169 Cysteine-rich domain; Region: CCG; pfam02754 247156014170 Cysteine-rich domain; Region: CCG; pfam02754 247156014171 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 247156014172 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 247156014173 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 247156014174 active site 247156014175 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 247156014176 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156014177 active site 247156014178 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 247156014179 putative active site [active] 247156014180 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 247156014181 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 247156014182 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 247156014183 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 247156014184 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 247156014185 nucleotide binding site [chemical binding]; other site 247156014186 YibE/F-like protein; Region: YibE_F; pfam07907 247156014187 aminotransferase AlaT; Validated; Region: PRK09265 247156014188 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 247156014189 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156014190 homodimer interface [polypeptide binding]; other site 247156014191 catalytic residue [active] 247156014192 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156014193 non-specific DNA binding site [nucleotide binding]; other site 247156014194 salt bridge; other site 247156014195 sequence-specific DNA binding site [nucleotide binding]; other site 247156014196 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 247156014197 trimer interface [polypeptide binding]; other site 247156014198 active site 247156014199 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156014200 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 247156014201 NAD(P) binding site [chemical binding]; other site 247156014202 active site 247156014203 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 247156014204 active site 247156014205 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 247156014206 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 247156014207 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 247156014208 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 247156014209 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 247156014210 active site 247156014211 dimer interface [polypeptide binding]; other site 247156014212 non-prolyl cis peptide bond; other site 247156014213 insertion regions; other site 247156014214 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 247156014215 GAF domain; Region: GAF_2; pfam13185 247156014216 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 247156014217 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 247156014218 active site 247156014219 Predicted transcriptional regulators [Transcription]; Region: COG1733 247156014220 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 247156014221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156014222 NAD(P) binding site [chemical binding]; other site 247156014223 active site 247156014224 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 247156014225 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 247156014226 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156014227 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156014228 enoyl-CoA hydratase; Provisional; Region: PRK08252 247156014229 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 247156014230 substrate binding site [chemical binding]; other site 247156014231 oxyanion hole (OAH) forming residues; other site 247156014232 trimer interface [polypeptide binding]; other site 247156014233 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 247156014234 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 247156014235 active site 247156014236 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 247156014237 Erythromycin esterase; Region: Erythro_esteras; pfam05139 247156014238 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156014239 S-adenosylmethionine binding site [chemical binding]; other site 247156014240 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 247156014241 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 247156014242 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 247156014243 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 247156014244 FAD binding site [chemical binding]; other site 247156014245 substrate binding site [chemical binding]; other site 247156014246 catalytic residues [active] 247156014247 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 247156014248 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 247156014249 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 247156014250 VanW like protein; Region: VanW; pfam04294 247156014251 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 247156014252 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 247156014253 Secretory lipase; Region: LIP; pfam03583 247156014254 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 247156014255 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 247156014256 dimer interface [polypeptide binding]; other site 247156014257 active site 247156014258 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 247156014259 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156014260 NAD(P) binding site [chemical binding]; other site 247156014261 active site 247156014262 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 247156014263 active site 2 [active] 247156014264 active site 1 [active] 247156014265 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156014266 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156014267 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 247156014268 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 247156014269 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 247156014270 Ligand Binding Site [chemical binding]; other site 247156014271 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 247156014272 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 247156014273 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 247156014274 Acyltransferase family; Region: Acyl_transf_3; pfam01757 247156014275 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 247156014276 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 247156014277 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 247156014278 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156014279 S-adenosylmethionine binding site [chemical binding]; other site 247156014280 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 247156014281 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 247156014282 NAD binding site [chemical binding]; other site 247156014283 catalytic residues [active] 247156014284 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 247156014285 active site 247156014286 substrate-binding site [chemical binding]; other site 247156014287 metal-binding site [ion binding] 247156014288 GTP binding site [chemical binding]; other site 247156014289 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 247156014290 Switch II region; other site 247156014291 G4 box; other site 247156014292 short chain dehydrogenase; Provisional; Region: PRK08267 247156014293 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156014294 NAD(P) binding site [chemical binding]; other site 247156014295 active site 247156014296 Secretory lipase; Region: LIP; pfam03583 247156014297 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 247156014298 LabA_like proteins; Region: LabA_like; cd06167 247156014299 putative metal binding site [ion binding]; other site 247156014300 MMPL family; Region: MMPL; pfam03176 247156014301 Protein export membrane protein; Region: SecD_SecF; cl14618 247156014302 MMPL family; Region: MMPL; pfam03176 247156014303 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 247156014304 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156014305 non-specific DNA binding site [nucleotide binding]; other site 247156014306 salt bridge; other site 247156014307 sequence-specific DNA binding site [nucleotide binding]; other site 247156014308 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 247156014309 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 247156014310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 247156014311 active site 247156014312 phosphorylation site [posttranslational modification] 247156014313 intermolecular recognition site; other site 247156014314 dimerization interface [polypeptide binding]; other site 247156014315 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 247156014316 DNA binding residues [nucleotide binding] 247156014317 dimerization interface [polypeptide binding]; other site 247156014318 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 247156014319 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 247156014320 ATP binding site [chemical binding]; other site 247156014321 G-X-G motif; other site 247156014322 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 247156014323 Domain of unknown function DUF20; Region: UPF0118; pfam01594 247156014324 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 247156014325 dimerization interface [polypeptide binding]; other site 247156014326 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 247156014327 cyclase homology domain; Region: CHD; cd07302 247156014328 nucleotidyl binding site; other site 247156014329 metal binding site [ion binding]; metal-binding site 247156014330 dimer interface [polypeptide binding]; other site 247156014331 Predicted integral membrane protein [Function unknown]; Region: COG0392 247156014332 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 247156014333 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 247156014334 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 247156014335 Dehydroquinase class II; Region: DHquinase_II; pfam01220 247156014336 trimer interface [polypeptide binding]; other site 247156014337 active site 247156014338 dimer interface [polypeptide binding]; other site 247156014339 Domain of unknown function (DUF385); Region: DUF385; cl04387 247156014340 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 247156014341 dimerization interface [polypeptide binding]; other site 247156014342 putative DNA binding site [nucleotide binding]; other site 247156014343 putative Zn2+ binding site [ion binding]; other site 247156014344 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 247156014345 putative hydrophobic ligand binding site [chemical binding]; other site 247156014346 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 247156014347 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 247156014348 Walker A/P-loop; other site 247156014349 ATP binding site [chemical binding]; other site 247156014350 Q-loop/lid; other site 247156014351 ABC transporter signature motif; other site 247156014352 Walker B; other site 247156014353 D-loop; other site 247156014354 H-loop/switch region; other site 247156014355 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 247156014356 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 247156014357 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156014358 salt bridge; other site 247156014359 non-specific DNA binding site [nucleotide binding]; other site 247156014360 sequence-specific DNA binding site [nucleotide binding]; other site 247156014361 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 247156014362 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 247156014363 Predicted transcriptional regulators [Transcription]; Region: COG1733 247156014364 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 247156014365 Glycerate kinase family; Region: Gly_kinase; cl00841 247156014366 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 247156014367 TAP-like protein; Region: Abhydrolase_4; pfam08386 247156014368 Predicted acetyltransferase [General function prediction only]; Region: COG2388 247156014369 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 247156014370 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 247156014371 putative acyl-acceptor binding pocket; other site 247156014372 hypothetical protein; Validated; Region: PRK00228 247156014373 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 247156014374 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 247156014375 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 247156014376 DNA binding residues [nucleotide binding] 247156014377 Putative zinc-finger; Region: zf-HC2; pfam13490 247156014378 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 247156014379 ABC-2 type transporter; Region: ABC2_membrane; cl17235 247156014380 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156014381 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 247156014382 Walker A/P-loop; other site 247156014383 ATP binding site [chemical binding]; other site 247156014384 Q-loop/lid; other site 247156014385 ABC transporter signature motif; other site 247156014386 Walker B; other site 247156014387 D-loop; other site 247156014388 H-loop/switch region; other site 247156014389 EXLDI protein; Region: EXLDI; TIGR04342 247156014390 hypothetical protein; Provisional; Region: PRK06154 247156014391 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 247156014392 PYR/PP interface [polypeptide binding]; other site 247156014393 dimer interface [polypeptide binding]; other site 247156014394 TPP binding site [chemical binding]; other site 247156014395 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 247156014396 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 247156014397 TPP-binding site [chemical binding]; other site 247156014398 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 247156014399 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 247156014400 active site 247156014401 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 247156014402 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 247156014403 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156014404 homodimer interface [polypeptide binding]; other site 247156014405 catalytic residue [active] 247156014406 Cupin domain; Region: Cupin_2; cl17218 247156014407 SdpI/YhfL protein family; Region: SdpI; pfam13630 247156014408 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 247156014409 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 247156014410 active site 247156014411 HIGH motif; other site 247156014412 nucleotide binding site [chemical binding]; other site 247156014413 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 247156014414 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 247156014415 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 247156014416 active site 247156014417 KMSKS motif; other site 247156014418 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 247156014419 tRNA binding surface [nucleotide binding]; other site 247156014420 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 247156014421 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 247156014422 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 247156014423 NodB motif; other site 247156014424 active site 247156014425 catalytic site [active] 247156014426 metal binding site [ion binding]; metal-binding site 247156014427 short chain dehydrogenase; Provisional; Region: PRK08219 247156014428 classical (c) SDRs; Region: SDR_c; cd05233 247156014429 NAD(P) binding site [chemical binding]; other site 247156014430 active site 247156014431 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 247156014432 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 247156014433 active site 247156014434 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 247156014435 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 247156014436 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 247156014437 putative dimer interface [polypeptide binding]; other site 247156014438 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 247156014439 ligand binding site [chemical binding]; other site 247156014440 Zn binding site [ion binding]; other site 247156014441 CHAT domain; Region: CHAT; cl17868 247156014442 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 247156014443 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 247156014444 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 247156014445 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 247156014446 tetramer interface [polypeptide binding]; other site 247156014447 heme binding pocket [chemical binding]; other site 247156014448 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 247156014449 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 247156014450 Walker A/P-loop; other site 247156014451 ATP binding site [chemical binding]; other site 247156014452 Q-loop/lid; other site 247156014453 ABC transporter signature motif; other site 247156014454 Walker B; other site 247156014455 D-loop; other site 247156014456 H-loop/switch region; other site 247156014457 TOBE domain; Region: TOBE_2; pfam08402 247156014458 Predicted transcriptional regulators [Transcription]; Region: COG1733 247156014459 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 247156014460 dimerization interface [polypeptide binding]; other site 247156014461 putative DNA binding site [nucleotide binding]; other site 247156014462 putative Zn2+ binding site [ion binding]; other site 247156014463 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 247156014464 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 247156014465 dimer interface [polypeptide binding]; other site 247156014466 active site 247156014467 O-succinylbenzoate synthase; Provisional; Region: PRK02901 247156014468 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 247156014469 active site 247156014470 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 247156014471 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 247156014472 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 247156014473 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 247156014474 dimer interface [polypeptide binding]; other site 247156014475 conserved gate region; other site 247156014476 putative PBP binding loops; other site 247156014477 ABC-ATPase subunit interface; other site 247156014478 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 247156014479 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 247156014480 dimer interface [polypeptide binding]; other site 247156014481 conserved gate region; other site 247156014482 putative PBP binding loops; other site 247156014483 ABC-ATPase subunit interface; other site 247156014484 Transglycosylase; Region: Transgly; pfam00912 247156014485 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 247156014486 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 247156014487 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 247156014488 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 247156014489 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 247156014490 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 247156014491 Predicted transcriptional regulators [Transcription]; Region: COG1695 247156014492 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 247156014493 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 247156014494 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 247156014495 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 247156014496 Transglycosylase; Region: Transgly; pfam00912 247156014497 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 247156014498 Predicted integral membrane protein [Function unknown]; Region: COG5650 247156014499 Predicted integral membrane protein [Function unknown]; Region: COG5650 247156014500 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 247156014501 putative metal binding site [ion binding]; other site 247156014502 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 247156014503 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 247156014504 putative metal binding site [ion binding]; other site 247156014505 Tellurium resistance protein; Region: Tellurium_res; pfam10138 247156014506 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 247156014507 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 247156014508 putative metal binding site [ion binding]; other site 247156014509 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 247156014510 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 247156014511 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 247156014512 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 247156014513 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 247156014514 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 247156014515 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 247156014516 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 247156014517 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 247156014518 putative metal binding site [ion binding]; other site 247156014519 hypothetical protein; Provisional; Region: PRK14013 247156014520 Domain of unknown function (DUF389); Region: DUF389; cl00781 247156014521 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 247156014522 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 247156014523 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 247156014524 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 247156014525 dimer interface [polypeptide binding]; other site 247156014526 ssDNA binding site [nucleotide binding]; other site 247156014527 tetramer (dimer of dimers) interface [polypeptide binding]; other site 247156014528 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 247156014529 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 247156014530 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 247156014531 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 247156014532 replicative DNA helicase; Validated; Region: PRK07773 247156014533 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 247156014534 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 247156014535 Walker A motif; other site 247156014536 ATP binding site [chemical binding]; other site 247156014537 Walker B motif; other site 247156014538 DNA binding loops [nucleotide binding] 247156014539 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 247156014540 protein-splicing catalytic site; other site 247156014541 thioester formation/cholesterol transfer; other site 247156014542 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 247156014543 protein-splicing catalytic site; other site 247156014544 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 247156014545 Cutinase; Region: Cutinase; pfam01083 247156014546 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156014547 Methyltransferase domain; Region: Methyltransf_31; pfam13847 247156014548 S-adenosylmethionine binding site [chemical binding]; other site 247156014549 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 247156014550 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 247156014551 Nitronate monooxygenase; Region: NMO; pfam03060 247156014552 CheD chemotactic sensory transduction; Region: CheD; cl00810 247156014553 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 247156014554 FMN binding site [chemical binding]; other site 247156014555 substrate binding site [chemical binding]; other site 247156014556 putative catalytic residue [active] 247156014557 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 247156014558 active site 247156014559 catalytic triad [active] 247156014560 oxyanion hole [active] 247156014561 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 247156014562 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 247156014563 Tenuivirus PVC2 protein; Region: Tenui_PVC2; pfam06656 247156014564 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 247156014565 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 247156014566 acyl-activating enzyme (AAE) consensus motif; other site 247156014567 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 247156014568 acyl-activating enzyme (AAE) consensus motif; other site 247156014569 putative AMP binding site [chemical binding]; other site 247156014570 putative active site [active] 247156014571 putative CoA binding site [chemical binding]; other site 247156014572 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 247156014573 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 247156014574 FMN binding site [chemical binding]; other site 247156014575 substrate binding site [chemical binding]; other site 247156014576 putative catalytic residue [active] 247156014577 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 247156014578 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 247156014579 active site 247156014580 Acyl transferase domain; Region: Acyl_transf_1; cl08282 247156014581 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 247156014582 KR domain; Region: KR; pfam08659 247156014583 NAD(P) binding site [chemical binding]; other site 247156014584 active site 247156014585 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 247156014586 RNA binding surface [nucleotide binding]; other site 247156014587 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 247156014588 NlpC/P60 family; Region: NLPC_P60; pfam00877 247156014589 AAA ATPase domain; Region: AAA_16; pfam13191 247156014590 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 247156014591 L-aspartate oxidase; Provisional; Region: PRK06175 247156014592 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 247156014593 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 247156014594 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 247156014595 catalytic loop [active] 247156014596 iron binding site [ion binding]; other site 247156014597 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 247156014598 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156014599 non-specific DNA binding site [nucleotide binding]; other site 247156014600 salt bridge; other site 247156014601 sequence-specific DNA binding site [nucleotide binding]; other site 247156014602 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 247156014603 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 247156014604 helix-hairpin-helix signature motif; other site 247156014605 active site 247156014606 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 247156014607 FAD binding domain; Region: FAD_binding_4; pfam01565 247156014608 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 247156014609 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 247156014610 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 247156014611 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156014612 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 247156014613 Walker A/P-loop; other site 247156014614 ATP binding site [chemical binding]; other site 247156014615 Q-loop/lid; other site 247156014616 ABC transporter signature motif; other site 247156014617 Walker B; other site 247156014618 D-loop; other site 247156014619 H-loop/switch region; other site 247156014620 Domain of unknown function (DUF397); Region: DUF397; pfam04149 247156014621 Domain of unknown function (DUF397); Region: DUF397; pfam04149 247156014622 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 247156014623 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 247156014624 NADP binding site [chemical binding]; other site 247156014625 dimer interface [polypeptide binding]; other site 247156014626 DNA polymerase IV; Validated; Region: PRK03352 247156014627 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 247156014628 active site 247156014629 DNA binding site [nucleotide binding] 247156014630 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 247156014631 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156014632 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 247156014633 CoenzymeA binding site [chemical binding]; other site 247156014634 subunit interaction site [polypeptide binding]; other site 247156014635 PHB binding site; other site 247156014636 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 247156014637 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 247156014638 ATP binding site [chemical binding]; other site 247156014639 Walker B motif; other site 247156014640 arginine finger; other site 247156014641 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 247156014642 TIGR03084 family protein; Region: TIGR03084 247156014643 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 247156014644 Wyosine base formation; Region: Wyosine_form; pfam08608 247156014645 hydroxyglutarate oxidase; Provisional; Region: PRK11728 247156014646 Predicted dehydrogenase [General function prediction only]; Region: COG0579 247156014647 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 247156014648 hydrophobic ligand binding site; other site 247156014649 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 247156014650 RNA/DNA hybrid binding site [nucleotide binding]; other site 247156014651 active site 247156014652 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 247156014653 mce related protein; Region: MCE; pfam02470 247156014654 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 247156014655 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 247156014656 mce related protein; Region: MCE; pfam02470 247156014657 mce related protein; Region: MCE; pfam02470 247156014658 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 247156014659 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 247156014660 mce related protein; Region: MCE; pfam02470 247156014661 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 247156014662 mce related protein; Region: MCE; pfam02470 247156014663 mce related protein; Region: MCE; pfam02470 247156014664 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 247156014665 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 247156014666 Permease; Region: Permease; pfam02405 247156014667 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 247156014668 Permease; Region: Permease; pfam02405 247156014669 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 247156014670 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 247156014671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156014672 putative substrate translocation pore; other site 247156014673 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 247156014674 Cytochrome P450; Region: p450; cl12078 247156014675 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 247156014676 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 247156014677 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 247156014678 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 247156014679 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 247156014680 active site 247156014681 Zn binding site [ion binding]; other site 247156014682 Domain of unknown function (DUF397); Region: DUF397; pfam04149 247156014683 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156014684 sequence-specific DNA binding site [nucleotide binding]; other site 247156014685 salt bridge; other site 247156014686 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 247156014687 Pirin; Region: Pirin; pfam02678 247156014688 Pirin-related protein [General function prediction only]; Region: COG1741 247156014689 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 247156014690 active site 247156014691 8-oxo-dGMP binding site [chemical binding]; other site 247156014692 nudix motif; other site 247156014693 metal binding site [ion binding]; metal-binding site 247156014694 SnoaL-like domain; Region: SnoaL_4; pfam13577 247156014695 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 247156014696 MarR family; Region: MarR_2; cl17246 247156014697 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 247156014698 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 247156014699 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 247156014700 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 247156014701 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 247156014702 putative active site [active] 247156014703 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 247156014704 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 247156014705 active site 247156014706 NTP binding site [chemical binding]; other site 247156014707 metal binding triad [ion binding]; metal-binding site 247156014708 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 247156014709 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 247156014710 Zn2+ binding site [ion binding]; other site 247156014711 Mg2+ binding site [ion binding]; other site 247156014712 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 247156014713 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 247156014714 active site 247156014715 Ap6A binding site [chemical binding]; other site 247156014716 nudix motif; other site 247156014717 metal binding site [ion binding]; metal-binding site 247156014718 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 247156014719 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 247156014720 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 247156014721 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 247156014722 DNA binding residues [nucleotide binding] 247156014723 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 247156014724 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 247156014725 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 247156014726 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 247156014727 catalytic residues [active] 247156014728 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 247156014729 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 247156014730 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 247156014731 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 247156014732 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 247156014733 active site 247156014734 metal binding site [ion binding]; metal-binding site 247156014735 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 247156014736 Coenzyme A binding pocket [chemical binding]; other site 247156014737 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 247156014738 ParB-like nuclease domain; Region: ParBc; pfam02195 247156014739 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 247156014740 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 247156014741 P-loop; other site 247156014742 Magnesium ion binding site [ion binding]; other site 247156014743 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 247156014744 Magnesium ion binding site [ion binding]; other site 247156014745 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 247156014746 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 247156014747 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 247156014748 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 247156014749 G-X-X-G motif; other site 247156014750 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 247156014751 RxxxH motif; other site 247156014752 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 247156014753 hypothetical protein; Validated; Region: PRK00041 247156014754 ribonuclease P; Reviewed; Region: rnpA; PRK03459 247156014755 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 247156014756 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 247156014757 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 247156014758 P-loop; other site 247156014759 Magnesium ion binding site [ion binding]; other site 247156014760 ParB-like nuclease domain; Region: ParB; smart00470 247156014761 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 247156014762 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 247156014763 DNA binding site [nucleotide binding] 247156014764 dimer interface [polypeptide binding]; other site 247156014765 active site 247156014766 Int/Topo IB signature motif; other site 247156014767 CAAX protease self-immunity; Region: Abi; pfam02517 247156014768 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 247156014769 cofactor binding site; other site 247156014770 DNA binding site [nucleotide binding] 247156014771 substrate interaction site [chemical binding]; other site 247156014772 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 247156014773 Integrase core domain; Region: rve; pfam00665 247156014774 Integrase core domain; Region: rve_3; cl15866 247156014775 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 247156014776 Protein of unknown function (DUF2677); Region: DUF2677; pfam10838 247156014777 Bacterial TniB protein; Region: TniB; pfam05621 247156014778 AAA domain; Region: AAA_22; pfam13401 247156014779 TniQ; Region: TniQ; pfam06527 247156014780 TniQ; Region: TniQ; pfam06527 247156014781 multiple promoter invertase; Provisional; Region: mpi; PRK13413 247156014782 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 247156014783 catalytic residues [active] 247156014784 catalytic nucleophile [active] 247156014785 Presynaptic Site I dimer interface [polypeptide binding]; other site 247156014786 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 247156014787 Synaptic Flat tetramer interface [polypeptide binding]; other site 247156014788 Synaptic Site I dimer interface [polypeptide binding]; other site 247156014789 DNA binding site [nucleotide binding] 247156014790 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 247156014791 DNA-binding interface [nucleotide binding]; DNA binding site 247156014792 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 247156014793 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 247156014794 Multicopper oxidase; Region: Cu-oxidase; pfam00394 247156014795 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 247156014796 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 247156014797 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 247156014798 dimer interface [polypeptide binding]; other site 247156014799 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156014800 catalytic residue [active] 247156014801 multidrug resistance protein MdtH; Provisional; Region: PRK11646 247156014802 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156014803 Tandemly repeated domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like; cl17916 247156014804 Domain of unknown function (DUF305); Region: DUF305; pfam03713 247156014805 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 247156014806 dimerization interface [polypeptide binding]; other site 247156014807 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 247156014808 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 247156014809 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 247156014810 Soluble P-type ATPase [General function prediction only]; Region: COG4087 247156014811 Predicted membrane protein [Function unknown]; Region: COG3462 247156014812 Short C-terminal domain; Region: SHOCT; pfam09851 247156014813 MMPL family; Region: MMPL; pfam03176 247156014814 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 247156014815 dimerization interface [polypeptide binding]; other site 247156014816 putative DNA binding site [nucleotide binding]; other site 247156014817 putative Zn2+ binding site [ion binding]; other site 247156014818 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 247156014819 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 247156014820 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 247156014821 motif II; other site 247156014822 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 247156014823 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156014824 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 247156014825 Cadmium resistance transporter; Region: Cad; pfam03596 247156014826 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 247156014827 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 247156014828 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 247156014829 amidase catalytic site [active] 247156014830 Zn binding residues [ion binding]; other site 247156014831 substrate binding site [chemical binding]; other site 247156014832 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 247156014833 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 247156014834 Protein of unknown function (DUF3703); Region: DUF3703; pfam12487 247156014835 Thioredoxin; Region: Thioredoxin_4; cl17273 247156014836 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 247156014837 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 247156014838 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 247156014839 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 247156014840 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 247156014841 catalytic residues [active] 247156014842 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 247156014843 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 247156014844 catalytic residues [active] 247156014845 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 247156014846 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 247156014847 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 247156014848 Peptidase family M23; Region: Peptidase_M23; pfam01551 247156014849 Domain of unknown function (DUF305); Region: DUF305; pfam03713 247156014850 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 247156014851 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 247156014852 CopC domain; Region: CopC; pfam04234 247156014853 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 247156014854 Penicillinase repressor; Region: Pencillinase_R; pfam03965 247156014855 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 247156014856 Sulfate transporter family; Region: Sulfate_transp; pfam00916 247156014857 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 247156014858 active site clefts [active] 247156014859 zinc binding site [ion binding]; other site 247156014860 dimer interface [polypeptide binding]; other site 247156014861 Predicted esterase [General function prediction only]; Region: COG0627 247156014862 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 247156014863 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 247156014864 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 247156014865 dimer interface [polypeptide binding]; other site 247156014866 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156014867 catalytic residue [active] 247156014868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156014869 putative substrate translocation pore; other site 247156014870 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 247156014871 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 247156014872 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 247156014873 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 247156014874 iron-sulfur cluster [ion binding]; other site 247156014875 [2Fe-2S] cluster binding site [ion binding]; other site 247156014876 AAA domain; Region: AAA_22; pfam13401 247156014877 AAA ATPase domain; Region: AAA_16; pfam13191 247156014878 Integrase core domain; Region: rve; pfam00665 247156014879 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 247156014880 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 247156014881 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 247156014882 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 247156014883 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 247156014884 LGFP repeat; Region: LGFP; pfam08310 247156014885 LGFP repeat; Region: LGFP; pfam08310 247156014886 LGFP repeat; Region: LGFP; pfam08310 247156014887 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 247156014888 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 247156014889 Multicopper oxidase; Region: Cu-oxidase; pfam00394 247156014890 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 247156014891 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 247156014892 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 247156014893 dimer interface [polypeptide binding]; other site 247156014894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 247156014895 catalytic residue [active] 247156014896 multidrug resistance protein MdtH; Provisional; Region: PRK11646 247156014897 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156014898 putative substrate translocation pore; other site 247156014899 Domain of unknown function (DUF305); Region: DUF305; pfam03713 247156014900 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 247156014901 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 247156014902 dimerization interface [polypeptide binding]; other site 247156014903 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 247156014904 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 247156014905 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 247156014906 Soluble P-type ATPase [General function prediction only]; Region: COG4087 247156014907 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 247156014908 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 247156014909 Walker A/P-loop; other site 247156014910 ATP binding site [chemical binding]; other site 247156014911 Q-loop/lid; other site 247156014912 ABC transporter signature motif; other site 247156014913 Walker B; other site 247156014914 D-loop; other site 247156014915 H-loop/switch region; other site 247156014916 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 247156014917 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 247156014918 DNA binding site [nucleotide binding] 247156014919 active site 247156014920 Int/Topo IB signature motif; other site 247156014921 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 247156014922 active site 247156014923 catalytic residues [active] 247156014924 DNA binding site [nucleotide binding] 247156014925 Int/Topo IB signature motif; other site 247156014926 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 247156014927 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 247156014928 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 247156014929 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 247156014930 active site 247156014931 metal binding site [ion binding]; metal-binding site 247156014932 interdomain interaction site; other site 247156014933 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 247156014934 catalytic residues [active] 247156014935 AAA domain; Region: AAA_31; pfam13614 247156014936 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 247156014937 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156014938 S-adenosylmethionine binding site [chemical binding]; other site 247156014939 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 247156014940 DEAD-like helicases superfamily; Region: DEXDc; smart00487 247156014941 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 247156014942 helicase superfamily c-terminal domain; Region: HELICc; smart00490 247156014943 nucleotide binding region [chemical binding]; other site 247156014944 ATP-binding site [chemical binding]; other site 247156014945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156014946 S-adenosylmethionine binding site [chemical binding]; other site 247156014947 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 247156014948 Radical SAM superfamily; Region: Radical_SAM; pfam04055 247156014949 FeS/SAM binding site; other site 247156014950 Radical SAM superfamily; Region: Radical_SAM; pfam04055 247156014951 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 247156014952 FeS/SAM binding site; other site 247156014953 Methyltransferase domain; Region: Methyltransf_31; pfam13847 247156014954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156014955 S-adenosylmethionine binding site [chemical binding]; other site 247156014956 putative phosphoketolase; Provisional; Region: PRK05261 247156014957 XFP N-terminal domain; Region: XFP_N; pfam09364 247156014958 XFP C-terminal domain; Region: XFP_C; pfam09363 247156014959 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 247156014960 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 247156014961 metal binding site [ion binding]; metal-binding site 247156014962 active site 247156014963 I-site; other site 247156014964 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 247156014965 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 247156014966 motif II; other site 247156014967 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 247156014968 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 247156014969 active site pocket [active] 247156014970 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 247156014971 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 247156014972 DNA-binding site [nucleotide binding]; DNA binding site 247156014973 UTRA domain; Region: UTRA; pfam07702 247156014974 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 247156014975 active site 247156014976 dimer interface [polypeptide binding]; other site 247156014977 NH_2: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_2; cd02652 247156014978 active site 247156014979 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156014980 non-specific DNA binding site [nucleotide binding]; other site 247156014981 salt bridge; other site 247156014982 sequence-specific DNA binding site [nucleotide binding]; other site 247156014983 Domain of unknown function (DUF397); Region: DUF397; pfam04149 247156014984 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 247156014985 metal ion-dependent adhesion site (MIDAS); other site 247156014986 MoxR-like ATPases [General function prediction only]; Region: COG0714 247156014987 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 247156014988 Walker A motif; other site 247156014989 ATP binding site [chemical binding]; other site 247156014990 Walker B motif; other site 247156014991 arginine finger; other site 247156014992 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 247156014993 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 247156014994 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 247156014995 AAA-like domain; Region: AAA_10; pfam12846 247156014996 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 247156014997 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 247156014998 N-acetyl-D-glucosamine binding site [chemical binding]; other site 247156014999 catalytic residue [active] 247156015000 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 247156015001 NlpC/P60 family; Region: NLPC_P60; pfam00877 247156015002 Cutinase; Region: Cutinase; pfam01083 247156015003 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156015004 non-specific DNA binding site [nucleotide binding]; other site 247156015005 salt bridge; other site 247156015006 sequence-specific DNA binding site [nucleotide binding]; other site 247156015007 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 247156015008 non-specific DNA binding site [nucleotide binding]; other site 247156015009 salt bridge; other site 247156015010 sequence-specific DNA binding site [nucleotide binding]; other site 247156015011 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 247156015012 Cytochrome P450; Region: p450; cl12078 247156015013 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 247156015014 S-adenosylmethionine binding site [chemical binding]; other site 247156015015 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 247156015016 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 247156015017 P-loop; other site 247156015018 Magnesium ion binding site [ion binding]; other site 247156015019 ParB-like nuclease domain; Region: ParBc; cl02129 247156015020 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 247156015021 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 247156015022 active site 247156015023 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 247156015024 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 247156015025 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 247156015026 DNA-binding site [nucleotide binding]; DNA binding site 247156015027 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 247156015028 Transcription factor WhiB; Region: Whib; pfam02467 247156015029 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 247156015030 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 247156015031 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 247156015032 active site 247156015033 metal binding site [ion binding]; metal-binding site 247156015034 interdomain interaction site; other site 247156015035 Abi-like protein; Region: Abi_2; pfam07751 247156015036 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 247156015037 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 247156015038 active site 247156015039 DNA binding site [nucleotide binding] 247156015040 Int/Topo IB signature motif; other site 247156015041 Predicted helicase [General function prediction only]; Region: COG4889 247156015042 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 247156015043 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 247156015044 ATP binding site [chemical binding]; other site 247156015045 putative Mg++ binding site [ion binding]; other site 247156015046 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 247156015047 dimerization interface [polypeptide binding]; other site 247156015048 putative DNA binding site [nucleotide binding]; other site 247156015049 putative Zn2+ binding site [ion binding]; other site 247156015050 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 247156015051 arsenical-resistance protein; Region: acr3; TIGR00832 247156015052 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 247156015053 Low molecular weight phosphatase family; Region: LMWPc; cl00105 247156015054 active site 247156015055 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 247156015056 Low molecular weight phosphatase family; Region: LMWPc; cd00115 247156015057 active site 247156015058 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 247156015059 Low molecular weight phosphatase family; Region: LMWPc; cd00115 247156015060 active site 247156015061 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 247156015062 DNA binding site [nucleotide binding] 247156015063 active site 247156015064 Int/Topo IB signature motif; other site 247156015065 catalytic residues [active] 247156015066 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 247156015067 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 247156015068 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 247156015069 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156015070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 247156015071 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 247156015072 CoenzymeA binding site [chemical binding]; other site 247156015073 subunit interaction site [polypeptide binding]; other site 247156015074 PHB binding site; other site 247156015075 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 247156015076 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 247156015077 catalytic residues [active] 247156015078 catalytic nucleophile [active] 247156015079 Presynaptic Site I dimer interface [polypeptide binding]; other site 247156015080 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 247156015081 Synaptic Flat tetramer interface [polypeptide binding]; other site 247156015082 Synaptic Site I dimer interface [polypeptide binding]; other site 247156015083 DNA binding site [nucleotide binding] 247156015084 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 247156015085 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 247156015086 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 247156015087 active site 247156015088 metal binding site [ion binding]; metal-binding site 247156015089 interdomain interaction site; other site 247156015090 AAA ATPase domain; Region: AAA_16; pfam13191 247156015091 Tetratricopeptide repeat; Region: TPR_12; pfam13424 247156015092 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 247156015093 binding surface 247156015094 TPR motif; other site 247156015095 Tetratricopeptide repeat; Region: TPR_12; pfam13424 247156015096 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 247156015097 binding surface 247156015098 TPR motif; other site 247156015099 Tetratricopeptide repeat; Region: TPR_12; pfam13424 247156015100 Tetratricopeptide repeat; Region: TPR_12; pfam13424 247156015101 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 247156015102 binding surface 247156015103 TPR motif; other site 247156015104 Tetratricopeptide repeat; Region: TPR_12; pfam13424 247156015105 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 247156015106 binding surface 247156015107 TPR motif; other site 247156015108 Tetratricopeptide repeat; Region: TPR_12; pfam13424 247156015109 Tetratricopeptide repeat; Region: TPR_12; pfam13424 247156015110 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 247156015111 binding surface 247156015112 TPR motif; other site 247156015113 Tetratricopeptide repeat; Region: TPR_12; pfam13424 247156015114 multiple promoter invertase; Provisional; Region: mpi; PRK13413 247156015115 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 247156015116 catalytic residues [active] 247156015117 catalytic nucleophile [active] 247156015118 Presynaptic Site I dimer interface [polypeptide binding]; other site 247156015119 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 247156015120 Synaptic Flat tetramer interface [polypeptide binding]; other site 247156015121 Synaptic Site I dimer interface [polypeptide binding]; other site 247156015122 DNA binding site [nucleotide binding] 247156015123 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 247156015124 DNA-binding interface [nucleotide binding]; DNA binding site 247156015125 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 247156015126 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 247156015127 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 247156015128 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 247156015129 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 247156015130 DNA binding residues [nucleotide binding] 247156015131 dimer interface [polypeptide binding]; other site 247156015132 mercury binding site [ion binding]; other site 247156015133 Alkylmercury lyase; Region: MerB; pfam03243 247156015134 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 247156015135 active site 247156015136 catalytic residues [active] 247156015137 DNA binding site [nucleotide binding] 247156015138 Int/Topo IB signature motif; other site 247156015139 Integrase core domain; Region: rve_3; pfam13683 247156015140 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 247156015141 Domain of unknown function DUF302; Region: DUF302; pfam03625 247156015142 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 247156015143 putative homodimer interface [polypeptide binding]; other site 247156015144 putative homotetramer interface [polypeptide binding]; other site 247156015145 putative allosteric switch controlling residues; other site 247156015146 putative metal binding site [ion binding]; other site 247156015147 putative homodimer-homodimer interface [polypeptide binding]; other site 247156015148 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 247156015149 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 247156015150 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 247156015151 catalytic residues [active] 247156015152 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 247156015153 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 247156015154 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 247156015155 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 247156015156 cofactor binding site; other site 247156015157 DNA binding site [nucleotide binding] 247156015158 substrate interaction site [chemical binding]; other site 247156015159 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 247156015160 ANTAR domain; Region: ANTAR; pfam03861 247156015161 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 247156015162 active site 247156015163 catalytic residues [active] 247156015164 DNA binding site [nucleotide binding] 247156015165 Int/Topo IB signature motif; other site 247156015166 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 247156015167 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 247156015168 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473