-- dump date 20140619_165147 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1205910000001 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1205910000002 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1205910000003 active site 1205910000004 HIGH motif; other site 1205910000005 dimer interface [polypeptide binding]; other site 1205910000006 KMSKS motif; other site 1205910000007 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1205910000008 RNA binding surface [nucleotide binding]; other site 1205910000009 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1205910000010 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1205910000011 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910000012 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910000013 WHG domain; Region: WHG; pfam13305 1205910000014 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1205910000015 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1205910000016 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1205910000017 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1205910000018 Nitrate and nitrite sensing; Region: NIT; pfam08376 1205910000019 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1205910000020 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910000021 ATP binding site [chemical binding]; other site 1205910000022 Mg2+ binding site [ion binding]; other site 1205910000023 G-X-G motif; other site 1205910000024 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1205910000025 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1205910000026 G1 box; other site 1205910000027 GTP/Mg2+ binding site [chemical binding]; other site 1205910000028 G2 box; other site 1205910000029 Switch I region; other site 1205910000030 G3 box; other site 1205910000031 Switch II region; other site 1205910000032 G4 box; other site 1205910000033 G5 box; other site 1205910000034 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1205910000035 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 1205910000036 Nitrate and nitrite sensing; Region: NIT; pfam08376 1205910000037 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1205910000038 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1205910000039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910000040 ATP binding site [chemical binding]; other site 1205910000041 Mg2+ binding site [ion binding]; other site 1205910000042 G-X-G motif; other site 1205910000043 argininosuccinate lyase; Provisional; Region: PRK00855 1205910000044 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1205910000045 active sites [active] 1205910000046 tetramer interface [polypeptide binding]; other site 1205910000047 Arginine repressor [Transcription]; Region: ArgR; COG1438 1205910000048 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1205910000049 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1205910000050 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1205910000051 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1205910000052 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1205910000053 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1205910000054 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1205910000055 inhibitor-cofactor binding pocket; inhibition site 1205910000056 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910000057 catalytic residue [active] 1205910000058 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1205910000059 homohexameric interface [polypeptide binding]; other site 1205910000060 feedback inhibition sensing region; other site 1205910000061 carbamate kinase; Reviewed; Region: PRK12686 1205910000062 nucleotide binding site [chemical binding]; other site 1205910000063 N-acetyl-L-glutamate binding site [chemical binding]; other site 1205910000064 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 1205910000065 active site pocket [active] 1205910000066 cleavage site 1205910000067 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1205910000068 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1205910000069 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1205910000070 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1205910000071 MarR family; Region: MarR_2; cl17246 1205910000072 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1205910000073 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 1205910000074 inhibitor-cofactor binding pocket; inhibition site 1205910000075 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910000076 catalytic residue [active] 1205910000077 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1205910000078 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1205910000079 putative tRNA-binding site [nucleotide binding]; other site 1205910000080 B3/4 domain; Region: B3_4; pfam03483 1205910000081 tRNA synthetase B5 domain; Region: B5; smart00874 1205910000082 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1205910000083 dimer interface [polypeptide binding]; other site 1205910000084 motif 1; other site 1205910000085 motif 3; other site 1205910000086 motif 2; other site 1205910000087 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1205910000088 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1205910000089 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1205910000090 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1205910000091 dimer interface [polypeptide binding]; other site 1205910000092 motif 1; other site 1205910000093 active site 1205910000094 motif 2; other site 1205910000095 motif 3; other site 1205910000096 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1205910000097 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1205910000098 putative active site [active] 1205910000099 heme pocket [chemical binding]; other site 1205910000100 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1205910000101 dimer interface [polypeptide binding]; other site 1205910000102 phosphorylation site [posttranslational modification] 1205910000103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910000104 ATP binding site [chemical binding]; other site 1205910000105 Mg2+ binding site [ion binding]; other site 1205910000106 G-X-G motif; other site 1205910000107 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1205910000108 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1205910000109 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1205910000110 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1205910000111 23S rRNA binding site [nucleotide binding]; other site 1205910000112 L21 binding site [polypeptide binding]; other site 1205910000113 L13 binding site [polypeptide binding]; other site 1205910000114 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1205910000115 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1205910000116 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1205910000117 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1205910000118 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1205910000119 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1205910000120 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1205910000121 shikimate binding site; other site 1205910000122 NAD(P) binding site [chemical binding]; other site 1205910000123 YceG-like family; Region: YceG; pfam02618 1205910000124 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 1205910000125 dimerization interface [polypeptide binding]; other site 1205910000126 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1205910000127 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1205910000128 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1205910000129 motif 1; other site 1205910000130 active site 1205910000131 motif 2; other site 1205910000132 motif 3; other site 1205910000133 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1205910000134 Protein kinase domain; Region: Pkinase; pfam00069 1205910000135 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205910000136 active site 1205910000137 ATP binding site [chemical binding]; other site 1205910000138 substrate binding site [chemical binding]; other site 1205910000139 recombination factor protein RarA; Reviewed; Region: PRK13342 1205910000140 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205910000141 Walker A motif; other site 1205910000142 ATP binding site [chemical binding]; other site 1205910000143 Walker B motif; other site 1205910000144 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1205910000145 PAS fold; Region: PAS_4; pfam08448 1205910000146 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1205910000147 putative active site [active] 1205910000148 heme pocket [chemical binding]; other site 1205910000149 PAS fold; Region: PAS_3; pfam08447 1205910000150 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1205910000151 GAF domain; Region: GAF; pfam01590 1205910000152 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1205910000153 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1205910000154 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1205910000155 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1205910000156 anticodon binding site; other site 1205910000157 dimer interface [polypeptide binding]; other site 1205910000158 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1205910000159 homodimer interface [polypeptide binding]; other site 1205910000160 motif 1; other site 1205910000161 active site 1205910000162 motif 2; other site 1205910000163 GAD domain; Region: GAD; pfam02938 1205910000164 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1205910000165 active site 1205910000166 motif 3; other site 1205910000167 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1205910000168 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1205910000169 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1205910000170 Domain of unknown function DUF11; Region: DUF11; pfam01345 1205910000171 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1205910000172 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1205910000173 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1205910000174 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1205910000175 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1205910000176 Flavoprotein; Region: Flavoprotein; pfam02441 1205910000177 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1205910000178 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1205910000179 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1205910000180 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1205910000181 catalytic site [active] 1205910000182 G-X2-G-X-G-K; other site 1205910000183 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 1205910000184 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1205910000185 active site 1205910000186 dimer interface [polypeptide binding]; other site 1205910000187 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1205910000188 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1205910000189 heterodimer interface [polypeptide binding]; other site 1205910000190 active site 1205910000191 FMN binding site [chemical binding]; other site 1205910000192 homodimer interface [polypeptide binding]; other site 1205910000193 substrate binding site [chemical binding]; other site 1205910000194 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 1205910000195 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1205910000196 FAD binding pocket [chemical binding]; other site 1205910000197 FAD binding motif [chemical binding]; other site 1205910000198 phosphate binding motif [ion binding]; other site 1205910000199 beta-alpha-beta structure motif; other site 1205910000200 NAD binding pocket [chemical binding]; other site 1205910000201 Iron coordination center [ion binding]; other site 1205910000202 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1205910000203 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1205910000204 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1205910000205 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1205910000206 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1205910000207 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1205910000208 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1205910000209 IMP binding site; other site 1205910000210 dimer interface [polypeptide binding]; other site 1205910000211 interdomain contacts; other site 1205910000212 partial ornithine binding site; other site 1205910000213 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1205910000214 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1205910000215 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1205910000216 catalytic site [active] 1205910000217 subunit interface [polypeptide binding]; other site 1205910000218 dihydroorotase; Validated; Region: pyrC; PRK09357 1205910000219 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1205910000220 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1205910000221 active site 1205910000222 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1205910000223 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1205910000224 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1205910000225 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 1205910000226 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1205910000227 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910000228 non-specific DNA binding site [nucleotide binding]; other site 1205910000229 salt bridge; other site 1205910000230 sequence-specific DNA binding site [nucleotide binding]; other site 1205910000231 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1205910000232 FAD binding site [chemical binding]; other site 1205910000233 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1205910000234 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1205910000235 substrate binding pocket [chemical binding]; other site 1205910000236 chain length determination region; other site 1205910000237 substrate-Mg2+ binding site; other site 1205910000238 catalytic residues [active] 1205910000239 aspartate-rich region 1; other site 1205910000240 active site lid residues [active] 1205910000241 aspartate-rich region 2; other site 1205910000242 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1205910000243 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1205910000244 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1205910000245 NADP binding site [chemical binding]; other site 1205910000246 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1205910000247 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1205910000248 NAD(P) binding site [chemical binding]; other site 1205910000249 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1205910000250 thiamine phosphate binding site [chemical binding]; other site 1205910000251 active site 1205910000252 pyrophosphate binding site [ion binding]; other site 1205910000253 Helix-turn-helix domain; Region: HTH_17; cl17695 1205910000254 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1205910000255 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1205910000256 thiS-thiF/thiG interaction site; other site 1205910000257 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1205910000258 ThiS interaction site; other site 1205910000259 putative active site [active] 1205910000260 tetramer interface [polypeptide binding]; other site 1205910000261 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205910000262 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205910000263 active site 1205910000264 ATP binding site [chemical binding]; other site 1205910000265 substrate binding site [chemical binding]; other site 1205910000266 activation loop (A-loop); other site 1205910000267 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1205910000268 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1205910000269 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1205910000270 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1205910000271 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1205910000272 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205910000273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910000274 active site 1205910000275 phosphorylation site [posttranslational modification] 1205910000276 intermolecular recognition site; other site 1205910000277 dimerization interface [polypeptide binding]; other site 1205910000278 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205910000279 DNA binding residues [nucleotide binding] 1205910000280 dimerization interface [polypeptide binding]; other site 1205910000281 phosphofructokinase; Region: PFK_mixed; TIGR02483 1205910000282 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1205910000283 active site 1205910000284 ADP/pyrophosphate binding site [chemical binding]; other site 1205910000285 dimerization interface [polypeptide binding]; other site 1205910000286 allosteric effector site; other site 1205910000287 fructose-1,6-bisphosphate binding site; other site 1205910000288 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1205910000289 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1205910000290 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1205910000291 Ligand Binding Site [chemical binding]; other site 1205910000292 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 1205910000293 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 1205910000294 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1205910000295 Moco binding site; other site 1205910000296 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1205910000297 metal coordination site [ion binding]; other site 1205910000298 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910000299 ATP binding site [chemical binding]; other site 1205910000300 Mg2+ binding site [ion binding]; other site 1205910000301 G-X-G motif; other site 1205910000302 Esterase/lipase [General function prediction only]; Region: COG1647 1205910000303 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1205910000304 catalytic site [active] 1205910000305 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1205910000306 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1205910000307 putative acyl-acceptor binding pocket; other site 1205910000308 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1205910000309 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1205910000310 nucleotide binding site [chemical binding]; other site 1205910000311 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1205910000312 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1205910000313 acyl-activating enzyme (AAE) consensus motif; other site 1205910000314 putative AMP binding site [chemical binding]; other site 1205910000315 putative active site [active] 1205910000316 putative CoA binding site [chemical binding]; other site 1205910000317 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1205910000318 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1205910000319 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1205910000320 heme bH binding site [chemical binding]; other site 1205910000321 intrachain domain interface; other site 1205910000322 heme bL binding site [chemical binding]; other site 1205910000323 interchain domain interface [polypeptide binding]; other site 1205910000324 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1205910000325 Qo binding site; other site 1205910000326 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1205910000327 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1205910000328 iron-sulfur cluster [ion binding]; other site 1205910000329 [2Fe-2S] cluster binding site [ion binding]; other site 1205910000330 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1205910000331 Cytochrome c; Region: Cytochrom_C; pfam00034 1205910000332 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1205910000333 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1205910000334 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1205910000335 Subunit I/III interface [polypeptide binding]; other site 1205910000336 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1205910000337 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1205910000338 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1205910000339 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1205910000340 AsnC family; Region: AsnC_trans_reg; pfam01037 1205910000341 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1205910000342 hypothetical protein; Validated; Region: PRK07883 1205910000343 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1205910000344 active site 1205910000345 catalytic site [active] 1205910000346 substrate binding site [chemical binding]; other site 1205910000347 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1205910000348 GIY-YIG motif/motif A; other site 1205910000349 active site 1205910000350 catalytic site [active] 1205910000351 putative DNA binding site [nucleotide binding]; other site 1205910000352 metal binding site [ion binding]; metal-binding site 1205910000353 YacP-like NYN domain; Region: NYN_YacP; cl01491 1205910000354 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 1205910000355 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1205910000356 NlpC/P60 family; Region: NLPC_P60; pfam00877 1205910000357 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1205910000358 NlpC/P60 family; Region: NLPC_P60; pfam00877 1205910000359 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1205910000360 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1205910000361 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1205910000362 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1205910000363 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1205910000364 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1205910000365 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1205910000366 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1205910000367 D-pathway; other site 1205910000368 Putative ubiquinol binding site [chemical binding]; other site 1205910000369 Low-spin heme (heme b) binding site [chemical binding]; other site 1205910000370 Putative water exit pathway; other site 1205910000371 Binuclear center (heme o3/CuB) [ion binding]; other site 1205910000372 K-pathway; other site 1205910000373 Putative proton exit pathway; other site 1205910000374 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 1205910000375 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1205910000376 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1205910000377 CPxP motif; other site 1205910000378 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1205910000379 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1205910000380 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1205910000381 RNA binding surface [nucleotide binding]; other site 1205910000382 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1205910000383 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 1205910000384 substrate binding site [chemical binding]; other site 1205910000385 ATP binding site [chemical binding]; other site 1205910000386 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 1205910000387 heat shock protein HtpX; Provisional; Region: PRK02391 1205910000388 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1205910000389 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1205910000390 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1205910000391 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1205910000392 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1205910000393 active site 1205910000394 catalytic tetrad [active] 1205910000395 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; pfam02283 1205910000396 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 1205910000397 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1205910000398 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1205910000399 interface (dimer of trimers) [polypeptide binding]; other site 1205910000400 Substrate-binding/catalytic site; other site 1205910000401 Zn-binding sites [ion binding]; other site 1205910000402 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1205910000403 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205910000404 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1205910000405 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1205910000406 E3 interaction surface; other site 1205910000407 lipoyl attachment site [posttranslational modification]; other site 1205910000408 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1205910000409 E3 interaction surface; other site 1205910000410 lipoyl attachment site [posttranslational modification]; other site 1205910000411 e3 binding domain; Region: E3_binding; pfam02817 1205910000412 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1205910000413 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1205910000414 Predicted flavoprotein [General function prediction only]; Region: COG0431 1205910000415 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205910000416 TIGR01777 family protein; Region: yfcH 1205910000417 NAD(P) binding site [chemical binding]; other site 1205910000418 active site 1205910000419 lipoate-protein ligase B; Provisional; Region: PRK14345 1205910000420 lipoyl synthase; Provisional; Region: PRK05481 1205910000421 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205910000422 FeS/SAM binding site; other site 1205910000423 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1205910000424 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910000425 non-specific DNA binding site [nucleotide binding]; other site 1205910000426 salt bridge; other site 1205910000427 sequence-specific DNA binding site [nucleotide binding]; other site 1205910000428 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 1205910000429 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1205910000430 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 1205910000431 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1205910000432 RDD family; Region: RDD; pfam06271 1205910000433 glutamine synthetase, type I; Region: GlnA; TIGR00653 1205910000434 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1205910000435 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1205910000436 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1205910000437 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1205910000438 metal binding triad; other site 1205910000439 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1205910000440 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1205910000441 metal binding triad; other site 1205910000442 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1205910000443 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1205910000444 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1205910000445 dimer interface [polypeptide binding]; other site 1205910000446 phosphorylation site [posttranslational modification] 1205910000447 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910000448 ATP binding site [chemical binding]; other site 1205910000449 Mg2+ binding site [ion binding]; other site 1205910000450 G-X-G motif; other site 1205910000451 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205910000452 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910000453 active site 1205910000454 phosphorylation site [posttranslational modification] 1205910000455 intermolecular recognition site; other site 1205910000456 dimerization interface [polypeptide binding]; other site 1205910000457 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205910000458 DNA binding site [nucleotide binding] 1205910000459 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1205910000460 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 1205910000461 active site 1205910000462 Ca binding site [ion binding]; other site 1205910000463 catalytic site [active] 1205910000464 Aamy_C domain; Region: Aamy_C; smart00632 1205910000465 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467 1205910000466 starch-binding site 2 [chemical binding]; other site 1205910000467 starch-binding site 1 [chemical binding]; other site 1205910000468 AAA ATPase domain; Region: AAA_16; pfam13191 1205910000469 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1205910000470 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205910000471 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205910000472 DNA binding residues [nucleotide binding] 1205910000473 dimerization interface [polypeptide binding]; other site 1205910000474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1205910000475 RibD C-terminal domain; Region: RibD_C; cl17279 1205910000476 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1205910000477 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1205910000478 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1205910000479 AAA ATPase domain; Region: AAA_16; pfam13191 1205910000480 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205910000481 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205910000482 DNA binding residues [nucleotide binding] 1205910000483 dimerization interface [polypeptide binding]; other site 1205910000484 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1205910000485 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1205910000486 heme-binding site [chemical binding]; other site 1205910000487 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1205910000488 FAD binding pocket [chemical binding]; other site 1205910000489 FAD binding motif [chemical binding]; other site 1205910000490 phosphate binding motif [ion binding]; other site 1205910000491 beta-alpha-beta structure motif; other site 1205910000492 NAD binding pocket [chemical binding]; other site 1205910000493 Heme binding pocket [chemical binding]; other site 1205910000494 Transcriptional regulator; Region: Rrf2; cl17282 1205910000495 Rrf2 family protein; Region: rrf2_super; TIGR00738 1205910000496 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1205910000497 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910000498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910000499 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1205910000500 oligomerization interface [polypeptide binding]; other site 1205910000501 active site 1205910000502 metal binding site [ion binding]; metal-binding site 1205910000503 H+ Antiporter protein; Region: 2A0121; TIGR00900 1205910000504 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205910000505 dimerization interface [polypeptide binding]; other site 1205910000506 putative DNA binding site [nucleotide binding]; other site 1205910000507 putative Zn2+ binding site [ion binding]; other site 1205910000508 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1205910000509 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1205910000510 NADPH-dependent F420 reductase; Region: npdG; TIGR01915 1205910000511 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1205910000512 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1205910000513 active site 1205910000514 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 1205910000515 SxDxEG motif; other site 1205910000516 active site 1205910000517 metal binding site [ion binding]; metal-binding site 1205910000518 homopentamer interface [polypeptide binding]; other site 1205910000519 hypothetical protein; Provisional; Region: PRK07906 1205910000520 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1205910000521 putative metal binding site [ion binding]; other site 1205910000522 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1205910000523 dimer interface [polypeptide binding]; other site 1205910000524 catalytic triad [active] 1205910000525 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1205910000526 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910000527 sequence-specific DNA binding site [nucleotide binding]; other site 1205910000528 salt bridge; other site 1205910000529 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205910000530 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205910000531 active site 1205910000532 Predicted transcriptional regulators [Transcription]; Region: COG1695 1205910000533 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1205910000534 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1205910000535 active site 1205910000536 metal binding site [ion binding]; metal-binding site 1205910000537 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910000538 putative substrate translocation pore; other site 1205910000539 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910000540 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910000541 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205910000542 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1205910000543 active site 1205910000544 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1205910000545 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1205910000546 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1205910000547 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1205910000548 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1205910000549 carboxyltransferase (CT) interaction site; other site 1205910000550 biotinylation site [posttranslational modification]; other site 1205910000551 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1205910000552 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1205910000553 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1205910000554 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1205910000555 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1205910000556 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1205910000557 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1205910000558 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1205910000559 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1205910000560 active site 1205910000561 catalytic motif [active] 1205910000562 Zn binding site [ion binding]; other site 1205910000563 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1205910000564 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1205910000565 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1205910000566 TM-ABC transporter signature motif; other site 1205910000567 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1205910000568 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1205910000569 TM-ABC transporter signature motif; other site 1205910000570 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1205910000571 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1205910000572 Q-loop/lid; other site 1205910000573 ABC transporter signature motif; other site 1205910000574 Walker B; other site 1205910000575 D-loop; other site 1205910000576 H-loop/switch region; other site 1205910000577 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1205910000578 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1205910000579 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1205910000580 ligand binding site [chemical binding]; other site 1205910000581 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1205910000582 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1205910000583 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1205910000584 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1205910000585 E3 interaction surface; other site 1205910000586 lipoyl attachment site [posttranslational modification]; other site 1205910000587 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1205910000588 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1205910000589 alpha subunit interface [polypeptide binding]; other site 1205910000590 TPP binding site [chemical binding]; other site 1205910000591 heterodimer interface [polypeptide binding]; other site 1205910000592 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1205910000593 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1205910000594 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1205910000595 tetramer interface [polypeptide binding]; other site 1205910000596 TPP-binding site [chemical binding]; other site 1205910000597 heterodimer interface [polypeptide binding]; other site 1205910000598 phosphorylation loop region [posttranslational modification] 1205910000599 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1205910000600 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205910000601 putative DNA binding site [nucleotide binding]; other site 1205910000602 putative Zn2+ binding site [ion binding]; other site 1205910000603 AsnC family; Region: AsnC_trans_reg; pfam01037 1205910000604 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1205910000605 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1205910000606 active site 1205910000607 substrate binding site [chemical binding]; other site 1205910000608 metal binding site [ion binding]; metal-binding site 1205910000609 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1205910000610 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1205910000611 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1205910000612 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1205910000613 NAD(P) binding site [chemical binding]; other site 1205910000614 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 1205910000615 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1205910000616 NAD(P) binding site [chemical binding]; other site 1205910000617 catalytic residues [active] 1205910000618 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1205910000619 intersubunit interface [polypeptide binding]; other site 1205910000620 active site 1205910000621 catalytic residue [active] 1205910000622 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 1205910000623 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 1205910000624 acyl-activating enzyme (AAE) consensus motif; other site 1205910000625 putative AMP binding site [chemical binding]; other site 1205910000626 putative active site [active] 1205910000627 putative CoA binding site [chemical binding]; other site 1205910000628 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1205910000629 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 1205910000630 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 1205910000631 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1205910000632 putative homotetramer interface [polypeptide binding]; other site 1205910000633 putative homodimer interface [polypeptide binding]; other site 1205910000634 putative allosteric switch controlling residues; other site 1205910000635 putative metal binding site [ion binding]; other site 1205910000636 putative homodimer-homodimer interface [polypeptide binding]; other site 1205910000637 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1205910000638 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205910000639 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1205910000640 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1205910000641 tetramer interface [polypeptide binding]; other site 1205910000642 heme binding pocket [chemical binding]; other site 1205910000643 NADPH binding site [chemical binding]; other site 1205910000644 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910000645 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910000646 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1205910000647 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1205910000648 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1205910000649 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1205910000650 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1205910000651 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1205910000652 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1205910000653 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1205910000654 carboxyltransferase (CT) interaction site; other site 1205910000655 biotinylation site [posttranslational modification]; other site 1205910000656 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205910000657 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205910000658 active site 1205910000659 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205910000660 active site 1205910000661 ATP binding site [chemical binding]; other site 1205910000662 substrate binding site [chemical binding]; other site 1205910000663 activation loop (A-loop); other site 1205910000664 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 1205910000665 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1205910000666 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1205910000667 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1205910000668 active site 1205910000669 dimer interface [polypeptide binding]; other site 1205910000670 motif 1; other site 1205910000671 motif 2; other site 1205910000672 motif 3; other site 1205910000673 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1205910000674 anticodon binding site; other site 1205910000675 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 1205910000676 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1205910000677 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 1205910000678 substrate-cofactor binding pocket; other site 1205910000679 homodimer interface [polypeptide binding]; other site 1205910000680 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910000681 catalytic residue [active] 1205910000682 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 1205910000683 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1205910000684 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1205910000685 Bacterial transcriptional regulator; Region: IclR; pfam01614 1205910000686 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1205910000687 hypothetical protein; Validated; Region: PRK06201 1205910000688 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 1205910000689 DctM-like transporters; Region: DctM; pfam06808 1205910000690 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1205910000691 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 1205910000692 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1205910000693 active site 1205910000694 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205910000695 DNA binding site [nucleotide binding] 1205910000696 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1205910000697 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1205910000698 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205910000699 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1205910000700 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1205910000701 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1205910000702 [4Fe-4S] binding site [ion binding]; other site 1205910000703 molybdopterin cofactor binding site; other site 1205910000704 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1205910000705 molybdopterin cofactor binding site; other site 1205910000706 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1205910000707 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1205910000708 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1205910000709 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 1205910000710 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1205910000711 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1205910000712 Bacterial transcriptional regulator; Region: IclR; pfam01614 1205910000713 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 1205910000714 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1205910000715 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1205910000716 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1205910000717 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1205910000718 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1205910000719 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205910000720 DNA-binding site [nucleotide binding]; DNA binding site 1205910000721 FCD domain; Region: FCD; pfam07729 1205910000722 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1205910000723 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1205910000724 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1205910000725 DNA binding site [nucleotide binding] 1205910000726 domain linker motif; other site 1205910000727 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1205910000728 dimerization interface [polypeptide binding]; other site 1205910000729 ligand binding site [chemical binding]; other site 1205910000730 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1205910000731 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1205910000732 Walker A/P-loop; other site 1205910000733 ATP binding site [chemical binding]; other site 1205910000734 Q-loop/lid; other site 1205910000735 ABC transporter signature motif; other site 1205910000736 Walker B; other site 1205910000737 D-loop; other site 1205910000738 H-loop/switch region; other site 1205910000739 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1205910000740 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1205910000741 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1205910000742 TM-ABC transporter signature motif; other site 1205910000743 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1205910000744 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1205910000745 ligand binding site [chemical binding]; other site 1205910000746 dimerization interface [polypeptide binding]; other site 1205910000747 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1205910000748 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1205910000749 substrate binding pocket [chemical binding]; other site 1205910000750 membrane-bound complex binding site; other site 1205910000751 hinge residues; other site 1205910000752 Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Region: SLC5sbd_DUR3; cd11476 1205910000753 Na binding site [ion binding]; other site 1205910000754 enoyl-CoA hydratase; Provisional; Region: PRK06688 1205910000755 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205910000756 substrate binding site [chemical binding]; other site 1205910000757 oxyanion hole (OAH) forming residues; other site 1205910000758 trimer interface [polypeptide binding]; other site 1205910000759 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; cl09957 1205910000760 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1205910000761 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205910000762 Cytochrome P450; Region: p450; cl12078 1205910000763 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205910000764 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1205910000765 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1205910000766 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910000767 ATP binding site [chemical binding]; other site 1205910000768 Mg2+ binding site [ion binding]; other site 1205910000769 G-X-G motif; other site 1205910000770 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205910000771 dimerization interface [polypeptide binding]; other site 1205910000772 putative DNA binding site [nucleotide binding]; other site 1205910000773 putative Zn2+ binding site [ion binding]; other site 1205910000774 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1205910000775 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1205910000776 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205910000777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910000778 active site 1205910000779 phosphorylation site [posttranslational modification] 1205910000780 intermolecular recognition site; other site 1205910000781 dimerization interface [polypeptide binding]; other site 1205910000782 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205910000783 dimerization interface [polypeptide binding]; other site 1205910000784 DNA binding residues [nucleotide binding] 1205910000785 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1205910000786 Histidine kinase; Region: HisKA_3; pfam07730 1205910000787 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1205910000788 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1205910000789 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1205910000790 Walker A/P-loop; other site 1205910000791 ATP binding site [chemical binding]; other site 1205910000792 Q-loop/lid; other site 1205910000793 ABC transporter signature motif; other site 1205910000794 Walker B; other site 1205910000795 D-loop; other site 1205910000796 H-loop/switch region; other site 1205910000797 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910000798 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1205910000799 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205910000800 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205910000801 active site 1205910000802 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910000803 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910000804 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1205910000805 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1205910000806 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1205910000807 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1205910000808 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205910000809 Coenzyme A binding pocket [chemical binding]; other site 1205910000810 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1205910000811 catalytic site [active] 1205910000812 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910000813 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910000814 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1205910000815 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910000816 putative substrate translocation pore; other site 1205910000817 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1205910000818 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1205910000819 dimer interface [polypeptide binding]; other site 1205910000820 putative functional site; other site 1205910000821 putative MPT binding site; other site 1205910000822 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1205910000823 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1205910000824 Bacterial transcriptional regulator; Region: IclR; pfam01614 1205910000825 SnoaL-like domain; Region: SnoaL_4; pfam13577 1205910000826 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1205910000827 classical (c) SDRs; Region: SDR_c; cd05233 1205910000828 NAD(P) binding site [chemical binding]; other site 1205910000829 active site 1205910000830 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 1205910000831 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910000832 metabolite-proton symporter; Region: 2A0106; TIGR00883 1205910000833 putative substrate translocation pore; other site 1205910000834 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1205910000835 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205910000836 NAD(P) binding site [chemical binding]; other site 1205910000837 active site 1205910000838 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1205910000839 DNA binding residues [nucleotide binding] 1205910000840 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1205910000841 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910000842 non-specific DNA binding site [nucleotide binding]; other site 1205910000843 salt bridge; other site 1205910000844 sequence-specific DNA binding site [nucleotide binding]; other site 1205910000845 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1205910000846 Helix-turn-helix domain; Region: HTH_17; pfam12728 1205910000847 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1205910000848 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1205910000849 ATP binding site [chemical binding]; other site 1205910000850 Mg2+ binding site [ion binding]; other site 1205910000851 G-X-G motif; other site 1205910000852 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1205910000853 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1205910000854 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1205910000855 Helix-turn-helix domain; Region: HTH_38; pfam13936 1205910000856 Integrase core domain; Region: rve; pfam00665 1205910000857 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1205910000858 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910000859 non-specific DNA binding site [nucleotide binding]; other site 1205910000860 salt bridge; other site 1205910000861 sequence-specific DNA binding site [nucleotide binding]; other site 1205910000862 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 1205910000863 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1205910000864 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 1205910000865 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910000866 S-adenosylmethionine binding site [chemical binding]; other site 1205910000867 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910000868 sequence-specific DNA binding site [nucleotide binding]; other site 1205910000869 salt bridge; other site 1205910000870 Cupin domain; Region: Cupin_2; pfam07883 1205910000871 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910000872 S-adenosylmethionine binding site [chemical binding]; other site 1205910000873 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1205910000874 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1205910000875 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1205910000876 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1205910000877 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1205910000878 nudix motif; other site 1205910000879 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 1205910000880 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1205910000881 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1205910000882 AsnC family; Region: AsnC_trans_reg; pfam01037 1205910000883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910000884 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1205910000885 putative substrate translocation pore; other site 1205910000886 Erythromycin esterase; Region: Erythro_esteras; pfam05139 1205910000887 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 1205910000888 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1205910000889 ResB-like family; Region: ResB; pfam05140 1205910000890 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1205910000891 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1205910000892 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1205910000893 putative active site [active] 1205910000894 redox center [active] 1205910000895 Thioredoxin; Region: Thioredoxin_4; pfam13462 1205910000896 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1205910000897 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1205910000898 Amidohydrolase; Region: Amidohydro_4; pfam13147 1205910000899 active site 1205910000900 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1205910000901 nucleoside/Zn binding site; other site 1205910000902 dimer interface [polypeptide binding]; other site 1205910000903 catalytic motif [active] 1205910000904 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1205910000905 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205910000906 DNA-binding site [nucleotide binding]; DNA binding site 1205910000907 FCD domain; Region: FCD; pfam07729 1205910000908 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1205910000909 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 1205910000910 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205910000911 Ligand Binding Site [chemical binding]; other site 1205910000912 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205910000913 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1205910000914 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1205910000915 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1205910000916 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1205910000917 pyruvate carboxylase; Reviewed; Region: PRK12999 1205910000918 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1205910000919 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1205910000920 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1205910000921 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1205910000922 active site 1205910000923 catalytic residues [active] 1205910000924 metal binding site [ion binding]; metal-binding site 1205910000925 homodimer binding site [polypeptide binding]; other site 1205910000926 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1205910000927 carboxyltransferase (CT) interaction site; other site 1205910000928 biotinylation site [posttranslational modification]; other site 1205910000929 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1205910000930 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1205910000931 NAD-dependent deacetylase; Provisional; Region: PRK00481 1205910000932 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1205910000933 Lysine efflux permease [General function prediction only]; Region: COG1279 1205910000934 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1205910000935 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1205910000936 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1205910000937 dimerization interface [polypeptide binding]; other site 1205910000938 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1205910000939 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1205910000940 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1205910000941 active site 1205910000942 catalytic tetrad [active] 1205910000943 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1205910000944 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1205910000945 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1205910000946 substrate binding site [chemical binding]; other site 1205910000947 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 1205910000948 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1205910000949 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1205910000950 active site 1205910000951 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1205910000952 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 1205910000953 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1205910000954 CHAT domain; Region: CHAT; cl17868 1205910000955 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1205910000956 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205910000957 substrate binding site [chemical binding]; other site 1205910000958 oxyanion hole (OAH) forming residues; other site 1205910000959 trimer interface [polypeptide binding]; other site 1205910000960 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1205910000961 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1205910000962 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 1205910000963 CoA binding domain; Region: CoA_binding_2; pfam13380 1205910000964 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1205910000965 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1205910000966 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1205910000967 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1205910000968 substrate binding site [chemical binding]; other site 1205910000969 ATP binding site [chemical binding]; other site 1205910000970 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1205910000971 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205910000972 ATP binding site [chemical binding]; other site 1205910000973 putative Mg++ binding site [ion binding]; other site 1205910000974 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205910000975 nucleotide binding region [chemical binding]; other site 1205910000976 ATP-binding site [chemical binding]; other site 1205910000977 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 1205910000978 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1205910000979 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1205910000980 CAP-like domain; other site 1205910000981 active site 1205910000982 primary dimer interface [polypeptide binding]; other site 1205910000983 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1205910000984 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1205910000985 active site clefts [active] 1205910000986 zinc binding site [ion binding]; other site 1205910000987 dimer interface [polypeptide binding]; other site 1205910000988 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1205910000989 binding surface 1205910000990 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1205910000991 TPR motif; other site 1205910000992 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1205910000993 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1205910000994 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205910000995 catalytic residue [active] 1205910000996 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1205910000997 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910000998 ATP binding site [chemical binding]; other site 1205910000999 Mg2+ binding site [ion binding]; other site 1205910001000 G-X-G motif; other site 1205910001001 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1205910001002 anchoring element; other site 1205910001003 dimer interface [polypeptide binding]; other site 1205910001004 ATP binding site [chemical binding]; other site 1205910001005 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1205910001006 active site 1205910001007 metal binding site [ion binding]; metal-binding site 1205910001008 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1205910001009 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1205910001010 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205910001011 Coenzyme A binding pocket [chemical binding]; other site 1205910001012 hypothetical protein; Validated; Region: PRK02101 1205910001013 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1205910001014 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1205910001015 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205910001016 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1205910001017 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205910001018 DNA binding residues [nucleotide binding] 1205910001019 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1205910001020 putative active site [active] 1205910001021 PAS fold; Region: PAS_3; pfam08447 1205910001022 heme pocket [chemical binding]; other site 1205910001023 GAF domain; Region: GAF; pfam01590 1205910001024 GAF domain; Region: GAF_2; pfam13185 1205910001025 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1205910001026 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1205910001027 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 1205910001028 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1205910001029 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1205910001030 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1205910001031 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1205910001032 active site 1205910001033 Substrate binding site; other site 1205910001034 Mg++ binding site; other site 1205910001035 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1205910001036 RNA/DNA hybrid binding site [nucleotide binding]; other site 1205910001037 active site 1205910001038 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1205910001039 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cd02106 1205910001040 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 1205910001041 SPFH domain / Band 7 family; Region: Band_7; pfam01145 1205910001042 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 1205910001043 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 1205910001044 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1205910001045 active site 1205910001046 dimer interface [polypeptide binding]; other site 1205910001047 effector binding site; other site 1205910001048 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1205910001049 TSCPD domain; Region: TSCPD; pfam12637 1205910001050 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1205910001051 ATP cone domain; Region: ATP-cone; pfam03477 1205910001052 LexA repressor; Validated; Region: PRK00215 1205910001053 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1205910001054 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1205910001055 Catalytic site [active] 1205910001056 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1205910001057 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1205910001058 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1205910001059 HIGH motif; other site 1205910001060 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1205910001061 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1205910001062 active site 1205910001063 KMSKS motif; other site 1205910001064 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1205910001065 tRNA binding surface [nucleotide binding]; other site 1205910001066 anticodon binding site; other site 1205910001067 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1205910001068 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1205910001069 acyl-activating enzyme (AAE) consensus motif; other site 1205910001070 putative AMP binding site [chemical binding]; other site 1205910001071 putative active site [active] 1205910001072 putative CoA binding site [chemical binding]; other site 1205910001073 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1205910001074 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910001075 dimer interface [polypeptide binding]; other site 1205910001076 conserved gate region; other site 1205910001077 putative PBP binding loops; other site 1205910001078 ABC-ATPase subunit interface; other site 1205910001079 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910001080 dimer interface [polypeptide binding]; other site 1205910001081 conserved gate region; other site 1205910001082 putative PBP binding loops; other site 1205910001083 ABC-ATPase subunit interface; other site 1205910001084 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1205910001085 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1205910001086 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1205910001087 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910001088 S-adenosylmethionine binding site [chemical binding]; other site 1205910001089 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1205910001090 FAD binding domain; Region: FAD_binding_4; pfam01565 1205910001091 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1205910001092 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1205910001093 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1205910001094 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1205910001095 putative Mg++ binding site [ion binding]; other site 1205910001096 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1205910001097 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1205910001098 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 1205910001099 putative hydrophobic ligand binding site [chemical binding]; other site 1205910001100 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205910001101 dimerization interface [polypeptide binding]; other site 1205910001102 putative DNA binding site [nucleotide binding]; other site 1205910001103 putative Zn2+ binding site [ion binding]; other site 1205910001104 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1205910001105 nudix motif; other site 1205910001106 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1205910001107 oligomerisation interface [polypeptide binding]; other site 1205910001108 mobile loop; other site 1205910001109 roof hairpin; other site 1205910001110 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910001111 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910001112 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1205910001113 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1205910001114 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910001115 Walker A/P-loop; other site 1205910001116 ATP binding site [chemical binding]; other site 1205910001117 Q-loop/lid; other site 1205910001118 ABC transporter signature motif; other site 1205910001119 Walker B; other site 1205910001120 D-loop; other site 1205910001121 H-loop/switch region; other site 1205910001122 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1205910001123 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1205910001124 phosphate binding site [ion binding]; other site 1205910001125 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1205910001126 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910001127 dimer interface [polypeptide binding]; other site 1205910001128 conserved gate region; other site 1205910001129 putative PBP binding loops; other site 1205910001130 ABC-ATPase subunit interface; other site 1205910001131 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1205910001132 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910001133 dimer interface [polypeptide binding]; other site 1205910001134 conserved gate region; other site 1205910001135 putative PBP binding loops; other site 1205910001136 ABC-ATPase subunit interface; other site 1205910001137 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1205910001138 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1205910001139 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1205910001140 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1205910001141 DNA binding site [nucleotide binding] 1205910001142 domain linker motif; other site 1205910001143 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1205910001144 ligand binding site [chemical binding]; other site 1205910001145 dimerization interface [polypeptide binding]; other site 1205910001146 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1205910001147 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1205910001148 active site 1205910001149 catalytic site [active] 1205910001150 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1205910001151 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205910001152 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1205910001153 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 1205910001154 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1205910001155 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205910001156 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1205910001157 Coenzyme A binding pocket [chemical binding]; other site 1205910001158 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205910001159 catalytic core [active] 1205910001160 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1205910001161 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1205910001162 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1205910001163 active site 1205910001164 (T/H)XGH motif; other site 1205910001165 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 1205910001166 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1205910001167 active site 1205910001168 DNA binding site [nucleotide binding] 1205910001169 Int/Topo IB signature motif; other site 1205910001170 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 1205910001171 polymerase nucleotide-binding site; other site 1205910001172 DNA-binding residues [nucleotide binding]; DNA binding site 1205910001173 nucleotide binding site [chemical binding]; other site 1205910001174 primase nucleotide-binding site [nucleotide binding]; other site 1205910001175 Homeodomain-like domain; Region: HTH_23; cl17451 1205910001176 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1205910001177 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1205910001178 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1205910001179 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 1205910001180 hypothetical protein; Provisional; Region: PRK07236 1205910001181 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1205910001182 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1205910001183 active site 1205910001184 FMN binding site [chemical binding]; other site 1205910001185 substrate binding site [chemical binding]; other site 1205910001186 homotetramer interface [polypeptide binding]; other site 1205910001187 catalytic residue [active] 1205910001188 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205910001189 CoA binding site [chemical binding]; other site 1205910001190 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205910001191 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1205910001192 acyl-activating enzyme (AAE) consensus motif; other site 1205910001193 active site 1205910001194 AMP binding site [chemical binding]; other site 1205910001195 CoA binding site [chemical binding]; other site 1205910001196 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205910001197 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1205910001198 active site 1205910001199 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1205910001200 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1205910001201 homotrimer interaction site [polypeptide binding]; other site 1205910001202 putative active site [active] 1205910001203 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205910001204 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1205910001205 substrate binding site [chemical binding]; other site 1205910001206 oxyanion hole (OAH) forming residues; other site 1205910001207 trimer interface [polypeptide binding]; other site 1205910001208 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 1205910001209 classical (c) SDRs; Region: SDR_c; cd05233 1205910001210 NAD(P) binding site [chemical binding]; other site 1205910001211 active site 1205910001212 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1205910001213 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1205910001214 putative catalytic cysteine [active] 1205910001215 PemK-like protein; Region: PemK; pfam02452 1205910001216 short chain dehydrogenase; Provisional; Region: PRK08251 1205910001217 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205910001218 NAD(P) binding site [chemical binding]; other site 1205910001219 active site 1205910001220 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1205910001221 gamma-glutamyl kinase; Provisional; Region: PRK05429 1205910001222 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1205910001223 nucleotide binding site [chemical binding]; other site 1205910001224 homotetrameric interface [polypeptide binding]; other site 1205910001225 putative phosphate binding site [ion binding]; other site 1205910001226 putative allosteric binding site; other site 1205910001227 PUA domain; Region: PUA; pfam01472 1205910001228 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1205910001229 GTP1/OBG; Region: GTP1_OBG; pfam01018 1205910001230 Obg GTPase; Region: Obg; cd01898 1205910001231 G1 box; other site 1205910001232 GTP/Mg2+ binding site [chemical binding]; other site 1205910001233 Switch I region; other site 1205910001234 G2 box; other site 1205910001235 G3 box; other site 1205910001236 Switch II region; other site 1205910001237 G4 box; other site 1205910001238 G5 box; other site 1205910001239 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1205910001240 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1205910001241 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1205910001242 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1205910001243 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1205910001244 homodimer interface [polypeptide binding]; other site 1205910001245 oligonucleotide binding site [chemical binding]; other site 1205910001246 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 1205910001247 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 1205910001248 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 1205910001249 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1205910001250 B12 binding site [chemical binding]; other site 1205910001251 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205910001252 FeS/SAM binding site; other site 1205910001253 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1205910001254 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1205910001255 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1205910001256 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1205910001257 rod shape-determining protein MreC; Provisional; Region: PRK13922 1205910001258 rod shape-determining protein MreC; Region: MreC; pfam04085 1205910001259 rod shape-determining protein MreB; Provisional; Region: PRK13927 1205910001260 MreB and similar proteins; Region: MreB_like; cd10225 1205910001261 nucleotide binding site [chemical binding]; other site 1205910001262 Mg binding site [ion binding]; other site 1205910001263 putative protofilament interaction site [polypeptide binding]; other site 1205910001264 RodZ interaction site [polypeptide binding]; other site 1205910001265 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1205910001266 active site 1205910001267 multimer interface [polypeptide binding]; other site 1205910001268 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1205910001269 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 1205910001270 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1205910001271 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1205910001272 Uncharacterized conserved protein [Function unknown]; Region: COG5276 1205910001273 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 1205910001274 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1205910001275 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1205910001276 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1205910001277 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205910001278 Walker A motif; other site 1205910001279 ATP binding site [chemical binding]; other site 1205910001280 Walker B motif; other site 1205910001281 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1205910001282 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1205910001283 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1205910001284 oligomer interface [polypeptide binding]; other site 1205910001285 active site residues [active] 1205910001286 Clp protease; Region: CLP_protease; pfam00574 1205910001287 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1205910001288 oligomer interface [polypeptide binding]; other site 1205910001289 active site residues [active] 1205910001290 trigger factor; Provisional; Region: tig; PRK01490 1205910001291 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1205910001292 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1205910001293 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1205910001294 active site 1205910001295 HIGH motif; other site 1205910001296 nucleotide binding site [chemical binding]; other site 1205910001297 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1205910001298 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1205910001299 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910001300 Walker A/P-loop; other site 1205910001301 ATP binding site [chemical binding]; other site 1205910001302 Q-loop/lid; other site 1205910001303 ABC transporter signature motif; other site 1205910001304 Walker B; other site 1205910001305 D-loop; other site 1205910001306 H-loop/switch region; other site 1205910001307 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1205910001308 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1205910001309 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1205910001310 Divalent cation transporter; Region: MgtE; pfam01769 1205910001311 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1205910001312 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1205910001313 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1205910001314 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1205910001315 NAD binding site [chemical binding]; other site 1205910001316 catalytic residues [active] 1205910001317 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1205910001318 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1205910001319 catalytic residues [active] 1205910001320 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1205910001321 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1205910001322 Zn binding site [ion binding]; other site 1205910001323 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1205910001324 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1205910001325 Nuclease-related domain; Region: NERD; pfam08378 1205910001326 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1205910001327 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 1205910001328 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1205910001329 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205910001330 active site 1205910001331 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1205910001332 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1205910001333 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1205910001334 active site 1205910001335 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1205910001336 apolar tunnel; other site 1205910001337 heme binding site [chemical binding]; other site 1205910001338 dimerization interface [polypeptide binding]; other site 1205910001339 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1205910001340 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1205910001341 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1205910001342 ABC transporter; Region: ABC_tran_2; pfam12848 1205910001343 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1205910001344 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1205910001345 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1205910001346 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1205910001347 metal binding site [ion binding]; metal-binding site 1205910001348 active site 1205910001349 I-site; other site 1205910001350 YfjP GTPase; Region: YfjP; cd11383 1205910001351 G1 box; other site 1205910001352 GTP/Mg2+ binding site [chemical binding]; other site 1205910001353 Switch I region; other site 1205910001354 G2 box; other site 1205910001355 Switch II region; other site 1205910001356 G3 box; other site 1205910001357 G4 box; other site 1205910001358 G5 box; other site 1205910001359 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1205910001360 Dynamin family; Region: Dynamin_N; pfam00350 1205910001361 G1 box; other site 1205910001362 GTP/Mg2+ binding site [chemical binding]; other site 1205910001363 G2 box; other site 1205910001364 Switch I region; other site 1205910001365 G3 box; other site 1205910001366 Switch II region; other site 1205910001367 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1205910001368 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1205910001369 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1205910001370 active site 1205910001371 SAM binding site [chemical binding]; other site 1205910001372 homodimer interface [polypeptide binding]; other site 1205910001373 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1205910001374 FMN binding site [chemical binding]; other site 1205910001375 dimer interface [polypeptide binding]; other site 1205910001376 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1205910001377 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1205910001378 putative dimer interface [polypeptide binding]; other site 1205910001379 active site pocket [active] 1205910001380 putative cataytic base [active] 1205910001381 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1205910001382 amidase catalytic site [active] 1205910001383 Zn binding residues [ion binding]; other site 1205910001384 substrate binding site [chemical binding]; other site 1205910001385 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1205910001386 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1205910001387 Coenzyme A binding pocket [chemical binding]; other site 1205910001388 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205910001389 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205910001390 active site 1205910001391 ATP binding site [chemical binding]; other site 1205910001392 substrate binding site [chemical binding]; other site 1205910001393 activation loop (A-loop); other site 1205910001394 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1205910001395 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1205910001396 NADP binding site [chemical binding]; other site 1205910001397 dimer interface [polypeptide binding]; other site 1205910001398 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1205910001399 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1205910001400 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1205910001401 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1205910001402 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1205910001403 active site 1205910001404 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1205910001405 Integrase core domain; Region: rve; pfam00665 1205910001406 Integrase core domain; Region: rve_3; pfam13683 1205910001407 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1205910001408 Transposase; Region: HTH_Tnp_1; pfam01527 1205910001409 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1205910001410 PLD-like domain; Region: PLDc_2; pfam13091 1205910001411 N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178 1205910001412 putative homodimer interface [polypeptide binding]; other site 1205910001413 putative active site [active] 1205910001414 catalytic site [active] 1205910001415 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1205910001416 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205910001417 ATP binding site [chemical binding]; other site 1205910001418 putative Mg++ binding site [ion binding]; other site 1205910001419 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205910001420 nucleotide binding region [chemical binding]; other site 1205910001421 ATP-binding site [chemical binding]; other site 1205910001422 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 1205910001423 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 1205910001424 putative metal binding residues [ion binding]; other site 1205910001425 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1205910001426 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1205910001427 Transposase; Region: HTH_Tnp_1; pfam01527 1205910001428 Integrase core domain; Region: rve; pfam00665 1205910001429 Integrase core domain; Region: rve_3; pfam13683 1205910001430 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1205910001431 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1205910001432 Int/Topo IB signature motif; other site 1205910001433 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1205910001434 Phosphotransferase enzyme family; Region: APH; pfam01636 1205910001435 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1205910001436 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1205910001437 nucleotide binding site/active site [active] 1205910001438 HIT family signature motif; other site 1205910001439 catalytic residue [active] 1205910001440 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 1205910001441 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1205910001442 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1205910001443 active site 1205910001444 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1205910001445 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1205910001446 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 1205910001447 active site 1205910001448 GIY-YIG motif/motif A; other site 1205910001449 catalytic site [active] 1205910001450 metal binding site [ion binding]; metal-binding site 1205910001451 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 1205910001452 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 1205910001453 NAD binding site [chemical binding]; other site 1205910001454 catalytic Zn binding site [ion binding]; other site 1205910001455 structural Zn binding site [ion binding]; other site 1205910001456 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1205910001457 Transposase; Region: HTH_Tnp_1; pfam01527 1205910001458 Integrase core domain; Region: rve; pfam00665 1205910001459 Integrase core domain; Region: rve_3; pfam13683 1205910001460 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1205910001461 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205910001462 DNA-binding site [nucleotide binding]; DNA binding site 1205910001463 UTRA domain; Region: UTRA; pfam07702 1205910001464 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1205910001465 nudix motif; other site 1205910001466 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205910001467 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205910001468 active site 1205910001469 ATP binding site [chemical binding]; other site 1205910001470 substrate binding site [chemical binding]; other site 1205910001471 activation loop (A-loop); other site 1205910001472 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1205910001473 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1205910001474 structural tetrad; other site 1205910001475 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1205910001476 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1205910001477 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 1205910001478 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1205910001479 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1205910001480 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1205910001481 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1205910001482 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1205910001483 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1205910001484 active site 1205910001485 metal binding site [ion binding]; metal-binding site 1205910001486 Thioredoxin; Region: Thioredoxin_4; pfam13462 1205910001487 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1205910001488 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1205910001489 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1205910001490 PQQ-like domain; Region: PQQ_2; pfam13360 1205910001491 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1205910001492 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1205910001493 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1205910001494 active site 1205910001495 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1205910001496 3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129 1205910001497 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1205910001498 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 1205910001499 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1205910001500 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910001501 non-specific DNA binding site [nucleotide binding]; other site 1205910001502 salt bridge; other site 1205910001503 sequence-specific DNA binding site [nucleotide binding]; other site 1205910001504 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1205910001505 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910001506 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1205910001507 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205910001508 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1205910001509 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910001510 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910001511 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 1205910001512 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205910001513 DNA-binding site [nucleotide binding]; DNA binding site 1205910001514 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205910001515 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910001516 homodimer interface [polypeptide binding]; other site 1205910001517 catalytic residue [active] 1205910001518 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1205910001519 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1205910001520 catalytic residue [active] 1205910001521 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1205910001522 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 1205910001523 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1205910001524 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1205910001525 active site 1205910001526 metal binding site [ion binding]; metal-binding site 1205910001527 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1205910001528 amidase catalytic site [active] 1205910001529 Zn binding residues [ion binding]; other site 1205910001530 substrate binding site [chemical binding]; other site 1205910001531 Predicted transcriptional regulators [Transcription]; Region: COG1695 1205910001532 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1205910001533 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1205910001534 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1205910001535 3-oxoacyl-acyl carrier protein synthase; Provisional; Region: PTZ00050 1205910001536 dimer interface [polypeptide binding]; other site 1205910001537 active site 1205910001538 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1205910001539 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1205910001540 active site 1205910001541 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1205910001542 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1205910001543 hydrophobic ligand binding site; other site 1205910001544 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1205910001545 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1205910001546 NAD(P) binding site [chemical binding]; other site 1205910001547 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1205910001548 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1205910001549 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1205910001550 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 1205910001551 active site 1205910001552 SAM binding site [chemical binding]; other site 1205910001553 homodimer interface [polypeptide binding]; other site 1205910001554 cobyric acid synthase; Provisional; Region: PRK00784 1205910001555 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1205910001556 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1205910001557 catalytic triad [active] 1205910001558 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 1205910001559 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1205910001560 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1205910001561 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910001562 Walker A/P-loop; other site 1205910001563 ATP binding site [chemical binding]; other site 1205910001564 Q-loop/lid; other site 1205910001565 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1205910001566 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910001567 Walker A/P-loop; other site 1205910001568 ATP binding site [chemical binding]; other site 1205910001569 Q-loop/lid; other site 1205910001570 ABC transporter signature motif; other site 1205910001571 Walker B; other site 1205910001572 D-loop; other site 1205910001573 H-loop/switch region; other site 1205910001574 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1205910001575 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1205910001576 catalytic triad [active] 1205910001577 hypothetical protein; Provisional; Region: PRK07908 1205910001578 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205910001579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910001580 homodimer interface [polypeptide binding]; other site 1205910001581 catalytic residue [active] 1205910001582 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1205910001583 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1205910001584 Walker A motif; other site 1205910001585 homodimer interface [polypeptide binding]; other site 1205910001586 ATP binding site [chemical binding]; other site 1205910001587 hydroxycobalamin binding site [chemical binding]; other site 1205910001588 Walker B motif; other site 1205910001589 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 1205910001590 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1205910001591 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1205910001592 metal ion-dependent adhesion site (MIDAS); other site 1205910001593 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1205910001594 active site 1205910001595 putative homodimer interface [polypeptide binding]; other site 1205910001596 SAM binding site [chemical binding]; other site 1205910001597 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1205910001598 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910001599 S-adenosylmethionine binding site [chemical binding]; other site 1205910001600 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 1205910001601 active site 1205910001602 homodimer interface [polypeptide binding]; other site 1205910001603 SAM binding site [chemical binding]; other site 1205910001604 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1205910001605 active site 1205910001606 SAM binding site [chemical binding]; other site 1205910001607 homodimer interface [polypeptide binding]; other site 1205910001608 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1205910001609 active site 1205910001610 SAM binding site [chemical binding]; other site 1205910001611 homodimer interface [polypeptide binding]; other site 1205910001612 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1205910001613 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1205910001614 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1205910001615 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1205910001616 metal binding site 2 [ion binding]; metal-binding site 1205910001617 putative DNA binding helix; other site 1205910001618 metal binding site 1 [ion binding]; metal-binding site 1205910001619 dimer interface [polypeptide binding]; other site 1205910001620 structural Zn2+ binding site [ion binding]; other site 1205910001621 argininosuccinate synthase; Validated; Region: PRK05370 1205910001622 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1205910001623 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493 1205910001624 Na binding site [ion binding]; other site 1205910001625 RNA ligase, DRB0094 family; Region: RNA_lig_DRB0094; TIGR02306 1205910001626 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320 1205910001627 putative tRNA-binding site [nucleotide binding]; other site 1205910001628 RNA ligase; Region: RNA_ligase; pfam09414 1205910001629 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1205910001630 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 1205910001631 DNA binding residues [nucleotide binding] 1205910001632 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1205910001633 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1205910001634 catalytic residues [active] 1205910001635 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1205910001636 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1205910001637 putative NAD(P) binding site [chemical binding]; other site 1205910001638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910001639 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1205910001640 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1205910001641 siderophore binding site; other site 1205910001642 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1205910001643 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1205910001644 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205910001645 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1205910001646 Coenzyme A binding pocket [chemical binding]; other site 1205910001647 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1205910001648 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1205910001649 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1205910001650 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1205910001651 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1205910001652 short chain dehydrogenase; Validated; Region: PRK06182 1205910001653 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1205910001654 NADP binding site [chemical binding]; other site 1205910001655 active site 1205910001656 steroid binding site; other site 1205910001657 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1205910001658 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910001659 S-adenosylmethionine binding site [chemical binding]; other site 1205910001660 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1205910001661 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1205910001662 active site 1205910001663 NTP binding site [chemical binding]; other site 1205910001664 metal binding triad [ion binding]; metal-binding site 1205910001665 antibiotic binding site [chemical binding]; other site 1205910001666 Predicted membrane protein [Function unknown]; Region: COG2311 1205910001667 Protein of unknown function (DUF418); Region: DUF418; cl12135 1205910001668 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1205910001669 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910001670 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910001671 BCCT family transporter; Region: BCCT; pfam02028 1205910001672 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1205910001673 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205910001674 motif II; other site 1205910001675 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205910001676 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1205910001677 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1205910001678 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1205910001679 active site 1205910001680 catalytic tetrad [active] 1205910001681 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1205910001682 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1205910001683 NAD(P) binding site [chemical binding]; other site 1205910001684 substrate binding site [chemical binding]; other site 1205910001685 dimer interface [polypeptide binding]; other site 1205910001686 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1205910001687 putative catalytic site [active] 1205910001688 putative metal binding site [ion binding]; other site 1205910001689 putative phosphate binding site [ion binding]; other site 1205910001690 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205910001691 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1205910001692 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1205910001693 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1205910001694 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1205910001695 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 1205910001696 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910001697 S-adenosylmethionine binding site [chemical binding]; other site 1205910001698 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1205910001699 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1205910001700 active site 1205910001701 iron coordination sites [ion binding]; other site 1205910001702 substrate binding pocket [chemical binding]; other site 1205910001703 Cupin; Region: Cupin_6; pfam12852 1205910001704 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1205910001705 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1205910001706 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205910001707 NAD(P) binding site [chemical binding]; other site 1205910001708 active site 1205910001709 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910001710 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910001711 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1205910001712 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1205910001713 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1205910001714 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1205910001715 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1205910001716 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 1205910001717 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1205910001718 DNA binding residues [nucleotide binding] 1205910001719 putative dimer interface [polypeptide binding]; other site 1205910001720 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1205910001721 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1205910001722 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205910001723 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910001724 active site 1205910001725 phosphorylation site [posttranslational modification] 1205910001726 intermolecular recognition site; other site 1205910001727 dimerization interface [polypeptide binding]; other site 1205910001728 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205910001729 DNA binding residues [nucleotide binding] 1205910001730 dimerization interface [polypeptide binding]; other site 1205910001731 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1205910001732 Histidine kinase; Region: HisKA_3; pfam07730 1205910001733 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910001734 ATP binding site [chemical binding]; other site 1205910001735 G-X-G motif; other site 1205910001736 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1205910001737 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1205910001738 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1205910001739 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1205910001740 Walker A/P-loop; other site 1205910001741 ATP binding site [chemical binding]; other site 1205910001742 Q-loop/lid; other site 1205910001743 ABC transporter signature motif; other site 1205910001744 Walker B; other site 1205910001745 D-loop; other site 1205910001746 H-loop/switch region; other site 1205910001747 hypothetical protein; Provisional; Region: PRK05463 1205910001748 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 1205910001749 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1205910001750 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1205910001751 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1205910001752 putative active site [active] 1205910001753 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1205910001754 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1205910001755 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205910001756 DNA-binding site [nucleotide binding]; DNA binding site 1205910001757 FCD domain; Region: FCD; pfam07729 1205910001758 hypothetical protein; Provisional; Region: PRK09266 1205910001759 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1205910001760 homodimer interface [polypeptide binding]; other site 1205910001761 substrate-cofactor binding pocket; other site 1205910001762 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910001763 catalytic residue [active] 1205910001764 MMPL family; Region: MMPL; pfam03176 1205910001765 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 1205910001766 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1205910001767 putative NAD(P) binding site [chemical binding]; other site 1205910001768 putative active site [active] 1205910001769 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1205910001770 potential frameshift: common BLAST hit: gi|297562500|ref|YP_003681474.1| MerR family transcriptional regulator 1205910001771 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1205910001772 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1205910001773 DNA binding residues [nucleotide binding] 1205910001774 Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834 1205910001775 lycopene cyclase; Region: lycopene_cycl; TIGR01789 1205910001776 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910001777 S-adenosylmethionine binding site [chemical binding]; other site 1205910001778 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1205910001779 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1205910001780 iron-sulfur cluster [ion binding]; other site 1205910001781 [2Fe-2S] cluster binding site [ion binding]; other site 1205910001782 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1205910001783 active site lid residues [active] 1205910001784 substrate binding pocket [chemical binding]; other site 1205910001785 catalytic residues [active] 1205910001786 substrate-Mg2+ binding site; other site 1205910001787 aspartate-rich region 1; other site 1205910001788 aspartate-rich region 2; other site 1205910001789 phytoene desaturase; Region: crtI_fam; TIGR02734 1205910001790 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1205910001791 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1205910001792 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1205910001793 substrate binding pocket [chemical binding]; other site 1205910001794 chain length determination region; other site 1205910001795 substrate-Mg2+ binding site; other site 1205910001796 catalytic residues [active] 1205910001797 aspartate-rich region 1; other site 1205910001798 active site lid residues [active] 1205910001799 aspartate-rich region 2; other site 1205910001800 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1205910001801 MarR family; Region: MarR; pfam01047 1205910001802 BCCT family transporter; Region: BCCT; pfam02028 1205910001803 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1205910001804 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1205910001805 putative dimer interface [polypeptide binding]; other site 1205910001806 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1205910001807 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1205910001808 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1205910001809 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1205910001810 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1205910001811 oligomer interface [polypeptide binding]; other site 1205910001812 RNA binding site [nucleotide binding]; other site 1205910001813 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1205910001814 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1205910001815 RNase E interface [polypeptide binding]; other site 1205910001816 trimer interface [polypeptide binding]; other site 1205910001817 active site 1205910001818 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1205910001819 putative nucleic acid binding region [nucleotide binding]; other site 1205910001820 G-X-X-G motif; other site 1205910001821 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1205910001822 RNA binding site [nucleotide binding]; other site 1205910001823 domain interface; other site 1205910001824 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1205910001825 16S/18S rRNA binding site [nucleotide binding]; other site 1205910001826 S13e-L30e interaction site [polypeptide binding]; other site 1205910001827 25S rRNA binding site [nucleotide binding]; other site 1205910001828 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1205910001829 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1205910001830 active site 1205910001831 Riboflavin kinase; Region: Flavokinase; smart00904 1205910001832 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1205910001833 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1205910001834 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1205910001835 RNA binding site [nucleotide binding]; other site 1205910001836 active site 1205910001837 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1205910001838 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1205910001839 Protein of unknown function (DUF503); Region: DUF503; pfam04456 1205910001840 potential frameshift: common BLAST hit: gi|297562525|ref|YP_003681499.1| translation initiation factor IF-2 1205910001841 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1205910001842 Translation-initiation factor 2; Region: IF-2; pfam11987 1205910001843 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1205910001844 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1205910001845 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1205910001846 G1 box; other site 1205910001847 putative GEF interaction site [polypeptide binding]; other site 1205910001848 GTP/Mg2+ binding site [chemical binding]; other site 1205910001849 Switch I region; other site 1205910001850 G2 box; other site 1205910001851 G3 box; other site 1205910001852 Switch II region; other site 1205910001853 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1205910001854 NusA N-terminal domain; Region: NusA_N; pfam08529 1205910001855 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1205910001856 RNA binding site [nucleotide binding]; other site 1205910001857 homodimer interface [polypeptide binding]; other site 1205910001858 NusA-like KH domain; Region: KH_5; pfam13184 1205910001859 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1205910001860 G-X-X-G motif; other site 1205910001861 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1205910001862 Sm and related proteins; Region: Sm_like; cl00259 1205910001863 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1205910001864 putative oligomer interface [polypeptide binding]; other site 1205910001865 putative RNA binding site [nucleotide binding]; other site 1205910001866 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1205910001867 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1205910001868 motif 1; other site 1205910001869 dimer interface [polypeptide binding]; other site 1205910001870 active site 1205910001871 motif 2; other site 1205910001872 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1205910001873 putative deacylase active site [active] 1205910001874 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1205910001875 active site 1205910001876 motif 3; other site 1205910001877 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1205910001878 anticodon binding site; other site 1205910001879 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1205910001880 S-adenosylmethionine binding site [chemical binding]; other site 1205910001881 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1205910001882 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1205910001883 Histidine kinase; Region: HisKA_3; pfam07730 1205910001884 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910001885 ATP binding site [chemical binding]; other site 1205910001886 Mg2+ binding site [ion binding]; other site 1205910001887 G-X-G motif; other site 1205910001888 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205910001889 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910001890 active site 1205910001891 intermolecular recognition site; other site 1205910001892 dimerization interface [polypeptide binding]; other site 1205910001893 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205910001894 DNA binding residues [nucleotide binding] 1205910001895 dimerization interface [polypeptide binding]; other site 1205910001896 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1205910001897 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1205910001898 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1205910001899 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1205910001900 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 1205910001901 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 1205910001902 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1205910001903 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205910001904 nucleotide binding region [chemical binding]; other site 1205910001905 ATP-binding site [chemical binding]; other site 1205910001906 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1205910001907 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1205910001908 Switch II region; other site 1205910001909 G4 box; other site 1205910001910 histidyl-tRNA synthetase; Region: hisS; TIGR00442 1205910001911 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1205910001912 dimer interface [polypeptide binding]; other site 1205910001913 motif 1; other site 1205910001914 active site 1205910001915 motif 2; other site 1205910001916 motif 3; other site 1205910001917 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1205910001918 anticodon binding site; other site 1205910001919 AAA ATPase domain; Region: AAA_16; pfam13191 1205910001920 Predicted ATPase [General function prediction only]; Region: COG3903 1205910001921 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205910001922 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205910001923 DNA binding residues [nucleotide binding] 1205910001924 dimerization interface [polypeptide binding]; other site 1205910001925 Predicted ATPase [General function prediction only]; Region: COG3903 1205910001926 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1205910001927 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1205910001928 binding surface 1205910001929 TPR motif; other site 1205910001930 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1205910001931 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1205910001932 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1205910001933 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205910001934 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205910001935 DNA binding residues [nucleotide binding] 1205910001936 dimerization interface [polypeptide binding]; other site 1205910001937 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205910001938 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1205910001939 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1205910001940 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 1205910001941 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1205910001942 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1205910001943 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1205910001944 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910001945 dimer interface [polypeptide binding]; other site 1205910001946 conserved gate region; other site 1205910001947 putative PBP binding loops; other site 1205910001948 ABC-ATPase subunit interface; other site 1205910001949 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1205910001950 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910001951 dimer interface [polypeptide binding]; other site 1205910001952 conserved gate region; other site 1205910001953 putative PBP binding loops; other site 1205910001954 ABC-ATPase subunit interface; other site 1205910001955 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1205910001956 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1205910001957 Walker A/P-loop; other site 1205910001958 ATP binding site [chemical binding]; other site 1205910001959 Q-loop/lid; other site 1205910001960 ABC transporter signature motif; other site 1205910001961 Walker B; other site 1205910001962 D-loop; other site 1205910001963 H-loop/switch region; other site 1205910001964 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1205910001965 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1205910001966 Walker A/P-loop; other site 1205910001967 ATP binding site [chemical binding]; other site 1205910001968 Q-loop/lid; other site 1205910001969 ABC transporter signature motif; other site 1205910001970 Walker B; other site 1205910001971 D-loop; other site 1205910001972 H-loop/switch region; other site 1205910001973 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1205910001974 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1205910001975 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 1205910001976 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1205910001977 Coenzyme A binding pocket [chemical binding]; other site 1205910001978 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1205910001979 TAP-like protein; Region: Abhydrolase_4; pfam08386 1205910001980 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1205910001981 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1205910001982 putative DNA binding site [nucleotide binding]; other site 1205910001983 putative Zn2+ binding site [ion binding]; other site 1205910001984 AsnC family; Region: AsnC_trans_reg; pfam01037 1205910001985 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205910001986 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1205910001987 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 1205910001988 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1205910001989 putative active site [active] 1205910001990 catalytic triad [active] 1205910001991 putative dimer interface [polypeptide binding]; other site 1205910001992 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1205910001993 MarR family; Region: MarR_2; pfam12802 1205910001994 hypothetical protein; Provisional; Region: PRK07236 1205910001995 hypothetical protein; Provisional; Region: PRK06847 1205910001996 amino acid transporter; Region: 2A0306; TIGR00909 1205910001997 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1205910001998 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1205910001999 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1205910002000 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1205910002001 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1205910002002 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1205910002003 active site 1205910002004 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1205910002005 protein binding site [polypeptide binding]; other site 1205910002006 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1205910002007 putative substrate binding region [chemical binding]; other site 1205910002008 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1205910002009 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1205910002010 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1205910002011 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1205910002012 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 1205910002013 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1205910002014 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 1205910002015 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1205910002016 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1205910002017 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1205910002018 NAD(P) binding site [chemical binding]; other site 1205910002019 catalytic residues [active] 1205910002020 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1205910002021 Zn2+ binding site [ion binding]; other site 1205910002022 Mg2+ binding site [ion binding]; other site 1205910002023 SdpI/YhfL protein family; Region: SdpI; pfam13630 1205910002024 Protein of unknown function, DUF393; Region: DUF393; pfam04134 1205910002025 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1205910002026 Histidine kinase; Region: HisKA_3; pfam07730 1205910002027 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205910002028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910002029 active site 1205910002030 phosphorylation site [posttranslational modification] 1205910002031 intermolecular recognition site; other site 1205910002032 dimerization interface [polypeptide binding]; other site 1205910002033 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205910002034 dimerization interface [polypeptide binding]; other site 1205910002035 DNA binding residues [nucleotide binding] 1205910002036 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205910002037 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205910002038 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205910002039 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205910002040 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1205910002041 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205910002042 Coenzyme A binding pocket [chemical binding]; other site 1205910002043 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1205910002044 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1205910002045 Walker A/P-loop; other site 1205910002046 ATP binding site [chemical binding]; other site 1205910002047 Q-loop/lid; other site 1205910002048 ABC transporter signature motif; other site 1205910002049 Walker B; other site 1205910002050 D-loop; other site 1205910002051 H-loop/switch region; other site 1205910002052 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1205910002053 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1205910002054 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1205910002055 Walker A/P-loop; other site 1205910002056 ATP binding site [chemical binding]; other site 1205910002057 Q-loop/lid; other site 1205910002058 ABC transporter signature motif; other site 1205910002059 Walker B; other site 1205910002060 D-loop; other site 1205910002061 H-loop/switch region; other site 1205910002062 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1205910002063 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1205910002064 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1205910002065 Probable transposase; Region: OrfB_IS605; pfam01385 1205910002066 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1205910002067 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1205910002068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910002069 dimer interface [polypeptide binding]; other site 1205910002070 conserved gate region; other site 1205910002071 putative PBP binding loops; other site 1205910002072 ABC-ATPase subunit interface; other site 1205910002073 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1205910002074 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910002075 dimer interface [polypeptide binding]; other site 1205910002076 conserved gate region; other site 1205910002077 putative PBP binding loops; other site 1205910002078 ABC-ATPase subunit interface; other site 1205910002079 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1205910002080 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1205910002081 peptide binding site [polypeptide binding]; other site 1205910002082 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1205910002083 AAA domain; Region: AAA_33; pfam13671 1205910002084 ATP-binding site [chemical binding]; other site 1205910002085 Gluconate-6-phosphate binding site [chemical binding]; other site 1205910002086 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1205910002087 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205910002088 DNA-binding site [nucleotide binding]; DNA binding site 1205910002089 FCD domain; Region: FCD; pfam07729 1205910002090 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1205910002091 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1205910002092 Phosphotransferase enzyme family; Region: APH; pfam01636 1205910002093 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1205910002094 active site 1205910002095 ATP binding site [chemical binding]; other site 1205910002096 Dienelactone hydrolase family; Region: DLH; pfam01738 1205910002097 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1205910002098 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 1205910002099 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1205910002100 CGNR zinc finger; Region: zf-CGNR; pfam11706 1205910002101 PQQ-like domain; Region: PQQ_2; pfam13360 1205910002102 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1205910002103 dimer interface [polypeptide binding]; other site 1205910002104 ADP-ribose binding site [chemical binding]; other site 1205910002105 active site 1205910002106 nudix motif; other site 1205910002107 metal binding site [ion binding]; metal-binding site 1205910002108 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1205910002109 IHF dimer interface [polypeptide binding]; other site 1205910002110 IHF - DNA interface [nucleotide binding]; other site 1205910002111 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1205910002112 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1205910002113 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910002114 non-specific DNA binding site [nucleotide binding]; other site 1205910002115 sequence-specific DNA binding site [nucleotide binding]; other site 1205910002116 salt bridge; other site 1205910002117 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1205910002118 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1205910002119 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1205910002120 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1205910002121 conserved cys residue [active] 1205910002122 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1205910002123 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 1205910002124 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205910002125 catalytic residue [active] 1205910002126 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1205910002127 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1205910002128 Bacterial transcriptional regulator; Region: IclR; pfam01614 1205910002129 glycerol kinase; Provisional; Region: glpK; PRK00047 1205910002130 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 1205910002131 N- and C-terminal domain interface [polypeptide binding]; other site 1205910002132 active site 1205910002133 MgATP binding site [chemical binding]; other site 1205910002134 catalytic site [active] 1205910002135 metal binding site [ion binding]; metal-binding site 1205910002136 putative homotetramer interface [polypeptide binding]; other site 1205910002137 glycerol binding site [chemical binding]; other site 1205910002138 homodimer interface [polypeptide binding]; other site 1205910002139 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1205910002140 amphipathic channel; other site 1205910002141 Asn-Pro-Ala signature motifs; other site 1205910002142 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910002143 sequence-specific DNA binding site [nucleotide binding]; other site 1205910002144 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1205910002145 salt bridge; other site 1205910002146 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1205910002147 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1205910002148 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1205910002149 DNA-binding site [nucleotide binding]; DNA binding site 1205910002150 RNA-binding motif; other site 1205910002151 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 1205910002152 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1205910002153 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1205910002154 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1205910002155 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1205910002156 Walker A/P-loop; other site 1205910002157 ATP binding site [chemical binding]; other site 1205910002158 Q-loop/lid; other site 1205910002159 ABC transporter signature motif; other site 1205910002160 Walker B; other site 1205910002161 D-loop; other site 1205910002162 H-loop/switch region; other site 1205910002163 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1205910002164 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1205910002165 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1205910002166 Walker A/P-loop; other site 1205910002167 ATP binding site [chemical binding]; other site 1205910002168 Q-loop/lid; other site 1205910002169 ABC transporter signature motif; other site 1205910002170 Walker B; other site 1205910002171 D-loop; other site 1205910002172 H-loop/switch region; other site 1205910002173 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1205910002174 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1205910002175 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910002176 dimer interface [polypeptide binding]; other site 1205910002177 conserved gate region; other site 1205910002178 putative PBP binding loops; other site 1205910002179 ABC-ATPase subunit interface; other site 1205910002180 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1205910002181 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910002182 dimer interface [polypeptide binding]; other site 1205910002183 conserved gate region; other site 1205910002184 putative PBP binding loops; other site 1205910002185 ABC-ATPase subunit interface; other site 1205910002186 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 1205910002187 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1205910002188 substrate binding site [chemical binding]; other site 1205910002189 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1205910002190 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1205910002191 DNA binding site [nucleotide binding] 1205910002192 domain linker motif; other site 1205910002193 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1205910002194 ligand binding site [chemical binding]; other site 1205910002195 dimerization interface [polypeptide binding]; other site 1205910002196 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1205910002197 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1205910002198 putative DNA binding site [nucleotide binding]; other site 1205910002199 catalytic residue [active] 1205910002200 putative H2TH interface [polypeptide binding]; other site 1205910002201 putative catalytic residues [active] 1205910002202 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1205910002203 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1205910002204 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1205910002205 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1205910002206 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 1205910002207 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1205910002208 inhibitor-cofactor binding pocket; inhibition site 1205910002209 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910002210 catalytic residue [active] 1205910002211 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1205910002212 EamA-like transporter family; Region: EamA; pfam00892 1205910002213 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1205910002214 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1205910002215 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1205910002216 putative dimerization interface [polypeptide binding]; other site 1205910002217 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1205910002218 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1205910002219 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1205910002220 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1205910002221 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1205910002222 inhibitor-cofactor binding pocket; inhibition site 1205910002223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910002224 catalytic residue [active] 1205910002225 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1205910002226 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1205910002227 tetrameric interface [polypeptide binding]; other site 1205910002228 NAD binding site [chemical binding]; other site 1205910002229 catalytic residues [active] 1205910002230 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1205910002231 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1205910002232 putative active site [active] 1205910002233 catalytic triad [active] 1205910002234 putative dimer interface [polypeptide binding]; other site 1205910002235 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1205910002236 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1205910002237 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205910002238 FeS/SAM binding site; other site 1205910002239 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1205910002240 H+ Antiporter protein; Region: 2A0121; TIGR00900 1205910002241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910002242 putative substrate translocation pore; other site 1205910002243 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1205910002244 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1205910002245 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1205910002246 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1205910002247 TPP-binding site [chemical binding]; other site 1205910002248 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1205910002249 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1205910002250 Predicted transcriptional regulators [Transcription]; Region: COG1695 1205910002251 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205910002252 putative DNA binding site [nucleotide binding]; other site 1205910002253 putative Zn2+ binding site [ion binding]; other site 1205910002254 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205910002255 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205910002256 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1205910002257 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1205910002258 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1205910002259 putative NAD(P) binding site [chemical binding]; other site 1205910002260 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1205910002261 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1205910002262 substrate binding pocket [chemical binding]; other site 1205910002263 membrane-bound complex binding site; other site 1205910002264 hinge residues; other site 1205910002265 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1205910002266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1205910002267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910002268 dimer interface [polypeptide binding]; other site 1205910002269 ABC-ATPase subunit interface; other site 1205910002270 putative PBP binding loops; other site 1205910002271 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1205910002272 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1205910002273 Walker A/P-loop; other site 1205910002274 ATP binding site [chemical binding]; other site 1205910002275 Q-loop/lid; other site 1205910002276 ABC transporter signature motif; other site 1205910002277 Walker B; other site 1205910002278 D-loop; other site 1205910002279 H-loop/switch region; other site 1205910002280 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1205910002281 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1205910002282 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1205910002283 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1205910002284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1205910002285 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 1205910002286 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205910002287 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1205910002288 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205910002289 DNA binding residues [nucleotide binding] 1205910002290 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1205910002291 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1205910002292 Transcription factor WhiB; Region: Whib; pfam02467 1205910002293 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1205910002294 PAS domain; Region: PAS_9; pfam13426 1205910002295 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1205910002296 Histidine kinase; Region: HisKA_2; pfam07568 1205910002297 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910002298 ATP binding site [chemical binding]; other site 1205910002299 Mg2+ binding site [ion binding]; other site 1205910002300 G-X-G motif; other site 1205910002301 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1205910002302 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205910002303 DNA-binding site [nucleotide binding]; DNA binding site 1205910002304 UTRA domain; Region: UTRA; pfam07702 1205910002305 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1205910002306 Zn2+ binding site [ion binding]; other site 1205910002307 Mg2+ binding site [ion binding]; other site 1205910002308 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1205910002309 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1205910002310 Zn2+ binding site [ion binding]; other site 1205910002311 Mg2+ binding site [ion binding]; other site 1205910002312 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 1205910002313 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1205910002314 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205910002315 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205910002316 DNA binding residues [nucleotide binding] 1205910002317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910002318 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1205910002319 ThiC-associated domain; Region: ThiC-associated; pfam13667 1205910002320 ThiC family; Region: ThiC; pfam01964 1205910002321 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1205910002322 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1205910002323 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 1205910002324 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1205910002325 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1205910002326 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1205910002327 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1205910002328 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1205910002329 active site 1205910002330 catalytic triad [active] 1205910002331 oxyanion hole [active] 1205910002332 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1205910002333 Interdomain contacts; other site 1205910002334 Cytokine receptor motif; other site 1205910002335 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1205910002336 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1205910002337 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1205910002338 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1205910002339 active site 1205910002340 dimer interface [polypeptide binding]; other site 1205910002341 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1205910002342 putative hydrophobic ligand binding site [chemical binding]; other site 1205910002343 protein interface [polypeptide binding]; other site 1205910002344 gate; other site 1205910002345 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1205910002346 intersubunit interface [polypeptide binding]; other site 1205910002347 Predicted transcriptional regulators [Transcription]; Region: COG1695 1205910002348 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1205910002349 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1205910002350 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205910002351 dimerization interface [polypeptide binding]; other site 1205910002352 putative DNA binding site [nucleotide binding]; other site 1205910002353 putative Zn2+ binding site [ion binding]; other site 1205910002354 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1205910002355 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1205910002356 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1205910002357 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1205910002358 SmpB-tmRNA interface; other site 1205910002359 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1205910002360 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1205910002361 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1205910002362 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910002363 Walker A/P-loop; other site 1205910002364 ATP binding site [chemical binding]; other site 1205910002365 Q-loop/lid; other site 1205910002366 ABC transporter signature motif; other site 1205910002367 Walker B; other site 1205910002368 D-loop; other site 1205910002369 H-loop/switch region; other site 1205910002370 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1205910002371 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1205910002372 RF-1 domain; Region: RF-1; pfam00472 1205910002373 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1205910002374 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 1205910002375 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1205910002376 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1205910002377 Helix-turn-helix domain; Region: HTH_31; pfam13560 1205910002378 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 1205910002379 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910002380 S-adenosylmethionine binding site [chemical binding]; other site 1205910002381 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205910002382 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1205910002383 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1205910002384 Coenzyme A binding pocket [chemical binding]; other site 1205910002385 Cytochrome P450; Region: p450; cl12078 1205910002386 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205910002387 epoxide hydrolase N-terminal domain-like phosphatase; Region: HAD-1A3-hyp; TIGR02247 1205910002388 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205910002389 motif II; other site 1205910002390 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1205910002391 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1205910002392 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1205910002393 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1205910002394 HPr interaction site; other site 1205910002395 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1205910002396 active site 1205910002397 phosphorylation site [posttranslational modification] 1205910002398 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 1205910002399 active site turn [active] 1205910002400 phosphorylation site [posttranslational modification] 1205910002401 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1205910002402 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1205910002403 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1205910002404 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205910002405 DNA-binding site [nucleotide binding]; DNA binding site 1205910002406 UTRA domain; Region: UTRA; pfam07702 1205910002407 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1205910002408 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1205910002409 dimer interface [polypeptide binding]; other site 1205910002410 active site 1205910002411 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1205910002412 dimer interface [polypeptide binding]; other site 1205910002413 active site 1205910002414 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1205910002415 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1205910002416 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205910002417 putative DNA binding site [nucleotide binding]; other site 1205910002418 putative Zn2+ binding site [ion binding]; other site 1205910002419 AsnC family; Region: AsnC_trans_reg; pfam01037 1205910002420 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1205910002421 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1205910002422 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1205910002423 nucleotide binding region [chemical binding]; other site 1205910002424 SEC-C motif; Region: SEC-C; pfam02810 1205910002425 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1205910002426 30S subunit binding site; other site 1205910002427 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1205910002428 active site 1205910002429 lipoprotein LpqB; Provisional; Region: PRK13613 1205910002430 Sporulation and spore germination; Region: Germane; pfam10646 1205910002431 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1205910002432 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1205910002433 dimerization interface [polypeptide binding]; other site 1205910002434 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1205910002435 dimer interface [polypeptide binding]; other site 1205910002436 phosphorylation site [posttranslational modification] 1205910002437 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910002438 ATP binding site [chemical binding]; other site 1205910002439 Mg2+ binding site [ion binding]; other site 1205910002440 G-X-G motif; other site 1205910002441 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205910002442 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910002443 active site 1205910002444 phosphorylation site [posttranslational modification] 1205910002445 intermolecular recognition site; other site 1205910002446 dimerization interface [polypeptide binding]; other site 1205910002447 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205910002448 DNA binding site [nucleotide binding] 1205910002449 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1205910002450 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 1205910002451 MoxR-like ATPases [General function prediction only]; Region: COG0714 1205910002452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205910002453 Walker A motif; other site 1205910002454 ATP binding site [chemical binding]; other site 1205910002455 Walker B motif; other site 1205910002456 arginine finger; other site 1205910002457 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1205910002458 Protein of unknown function DUF58; Region: DUF58; pfam01882 1205910002459 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1205910002460 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1205910002461 Tetratricopeptide repeat; Region: TPR_10; cl17452 1205910002462 Integral membrane protein DUF95; Region: DUF95; pfam01944 1205910002463 RDD family; Region: RDD; pfam06271 1205910002464 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1205910002465 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1205910002466 homotetramer interface [polypeptide binding]; other site 1205910002467 ligand binding site [chemical binding]; other site 1205910002468 catalytic site [active] 1205910002469 NAD binding site [chemical binding]; other site 1205910002470 Adenosylhomocysteinase; Provisional; Region: PTZ00075 1205910002471 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1205910002472 homotetramer interface [polypeptide binding]; other site 1205910002473 ligand binding site [chemical binding]; other site 1205910002474 catalytic site [active] 1205910002475 NAD binding site [chemical binding]; other site 1205910002476 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1205910002477 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1205910002478 DNA binding residues [nucleotide binding] 1205910002479 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205910002480 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205910002481 active site 1205910002482 ATP binding site [chemical binding]; other site 1205910002483 substrate binding site [chemical binding]; other site 1205910002484 activation loop (A-loop); other site 1205910002485 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1205910002486 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1205910002487 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1205910002488 active site 1205910002489 substrate binding site [chemical binding]; other site 1205910002490 metal binding site [ion binding]; metal-binding site 1205910002491 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1205910002492 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1205910002493 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1205910002494 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1205910002495 Probable Catalytic site; other site 1205910002496 metal-binding site 1205910002497 Transcription factor WhiB; Region: Whib; pfam02467 1205910002498 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 1205910002499 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1205910002500 phosphate binding site [ion binding]; other site 1205910002501 dimer interface [polypeptide binding]; other site 1205910002502 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 1205910002503 F420-0:gamma-glutamyl ligase; Region: F420_cofE; TIGR01916 1205910002504 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 1205910002505 putative FMN binding site [chemical binding]; other site 1205910002506 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1205910002507 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 1205910002508 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 1205910002509 putative active site [active] 1205910002510 FO synthase; Reviewed; Region: fbiC; PRK09234 1205910002511 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205910002512 FeS/SAM binding site; other site 1205910002513 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205910002514 FeS/SAM binding site; other site 1205910002515 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 1205910002516 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1205910002517 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1205910002518 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1205910002519 Ligand binding site; other site 1205910002520 Putative Catalytic site; other site 1205910002521 DXD motif; other site 1205910002522 oligosaccharyl transferase, archaeosortase A system-associated; Region: archaeo_STT3; TIGR04154 1205910002523 TIGR03089 family protein; Region: TIGR03089 1205910002524 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1205910002525 Amidohydrolase; Region: Amidohydro_4; pfam13147 1205910002526 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1205910002527 active site 1205910002528 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910002529 non-specific DNA binding site [nucleotide binding]; other site 1205910002530 salt bridge; other site 1205910002531 sequence-specific DNA binding site [nucleotide binding]; other site 1205910002532 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1205910002533 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1205910002534 active site 1205910002535 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1205910002536 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1205910002537 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205910002538 catalytic residue [active] 1205910002539 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1205910002540 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1205910002541 hinge; other site 1205910002542 active site 1205910002543 Predicted GTPases [General function prediction only]; Region: COG1162 1205910002544 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1205910002545 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1205910002546 GTP/Mg2+ binding site [chemical binding]; other site 1205910002547 G4 box; other site 1205910002548 G1 box; other site 1205910002549 Switch I region; other site 1205910002550 G2 box; other site 1205910002551 G3 box; other site 1205910002552 Switch II region; other site 1205910002553 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910002554 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910002555 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1205910002556 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1205910002557 active site 1205910002558 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1205910002559 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1205910002560 FtsX-like permease family; Region: FtsX; pfam02687 1205910002561 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1205910002562 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1205910002563 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1205910002564 Walker A/P-loop; other site 1205910002565 ATP binding site [chemical binding]; other site 1205910002566 Q-loop/lid; other site 1205910002567 ABC transporter signature motif; other site 1205910002568 Walker B; other site 1205910002569 D-loop; other site 1205910002570 H-loop/switch region; other site 1205910002571 Uncharacterized conserved protein [Function unknown]; Region: COG1615 1205910002572 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 1205910002573 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1205910002574 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1205910002575 protein binding site [polypeptide binding]; other site 1205910002576 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1205910002577 MoaE homodimer interface [polypeptide binding]; other site 1205910002578 MoaD interaction [polypeptide binding]; other site 1205910002579 active site residues [active] 1205910002580 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205910002581 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1205910002582 NAD(P) binding site [chemical binding]; other site 1205910002583 active site 1205910002584 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1205910002585 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 1205910002586 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 1205910002587 nudix motif; other site 1205910002588 Protein of unknown function DUF45; Region: DUF45; pfam01863 1205910002589 Transcription factor WhiB; Region: Whib; pfam02467 1205910002590 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1205910002591 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1205910002592 active site 1205910002593 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1205910002594 catalytic triad [active] 1205910002595 dimer interface [polypeptide binding]; other site 1205910002596 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1205910002597 Part of AAA domain; Region: AAA_19; pfam13245 1205910002598 Family description; Region: UvrD_C_2; pfam13538 1205910002599 HRDC domain; Region: HRDC; pfam00570 1205910002600 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1205910002601 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1205910002602 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1205910002603 putative NADH binding site [chemical binding]; other site 1205910002604 putative active site [active] 1205910002605 nudix motif; other site 1205910002606 putative metal binding site [ion binding]; other site 1205910002607 hypothetical protein; Provisional; Region: PRK08201 1205910002608 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 1205910002609 metal binding site [ion binding]; metal-binding site 1205910002610 putative dimer interface [polypeptide binding]; other site 1205910002611 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 1205910002612 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1205910002613 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1205910002614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910002615 dimer interface [polypeptide binding]; other site 1205910002616 conserved gate region; other site 1205910002617 putative PBP binding loops; other site 1205910002618 ABC-ATPase subunit interface; other site 1205910002619 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 1205910002620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910002621 dimer interface [polypeptide binding]; other site 1205910002622 conserved gate region; other site 1205910002623 putative PBP binding loops; other site 1205910002624 ABC-ATPase subunit interface; other site 1205910002625 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1205910002626 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910002627 Walker A/P-loop; other site 1205910002628 ATP binding site [chemical binding]; other site 1205910002629 Q-loop/lid; other site 1205910002630 ABC transporter signature motif; other site 1205910002631 Walker B; other site 1205910002632 D-loop; other site 1205910002633 H-loop/switch region; other site 1205910002634 TOBE domain; Region: TOBE_2; pfam08402 1205910002635 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 1205910002636 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205910002637 motif II; other site 1205910002638 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 1205910002639 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1205910002640 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205910002641 DNA-binding site [nucleotide binding]; DNA binding site 1205910002642 UTRA domain; Region: UTRA; pfam07702 1205910002643 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1205910002644 EF-hand domain pair; Region: EF_hand_5; pfam13499 1205910002645 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 1205910002646 EF-hand domain pair; Region: EF_hand_5; pfam13499 1205910002647 Ca2+ binding site [ion binding]; other site 1205910002648 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1205910002649 Part of AAA domain; Region: AAA_19; pfam13245 1205910002650 Family description; Region: UvrD_C_2; pfam13538 1205910002651 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1205910002652 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1205910002653 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1205910002654 Family description; Region: UvrD_C_2; pfam13538 1205910002655 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1205910002656 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1205910002657 DNA binding site [nucleotide binding] 1205910002658 active site 1205910002659 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 1205910002660 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1205910002661 ATP binding site [chemical binding]; other site 1205910002662 substrate interface [chemical binding]; other site 1205910002663 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1205910002664 active site residue [active] 1205910002665 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910002666 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910002667 Conserved TM helix; Region: TM_helix; pfam05552 1205910002668 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1205910002669 dinuclear metal binding motif [ion binding]; other site 1205910002670 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1205910002671 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1205910002672 ATP binding site [chemical binding]; other site 1205910002673 Mg++ binding site [ion binding]; other site 1205910002674 motif III; other site 1205910002675 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205910002676 nucleotide binding region [chemical binding]; other site 1205910002677 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1205910002678 Putative serine esterase (DUF676); Region: DUF676; pfam05057 1205910002679 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1205910002680 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1205910002681 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1205910002682 active site 1205910002683 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1205910002684 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1205910002685 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 1205910002686 G1 box; other site 1205910002687 putative GEF interaction site [polypeptide binding]; other site 1205910002688 GTP/Mg2+ binding site [chemical binding]; other site 1205910002689 Switch I region; other site 1205910002690 G2 box; other site 1205910002691 G3 box; other site 1205910002692 Switch II region; other site 1205910002693 G4 box; other site 1205910002694 G5 box; other site 1205910002695 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1205910002696 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1205910002697 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1205910002698 active site 1205910002699 8-oxo-dGMP binding site [chemical binding]; other site 1205910002700 nudix motif; other site 1205910002701 metal binding site [ion binding]; metal-binding site 1205910002702 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1205910002703 AAA domain; Region: AAA_30; pfam13604 1205910002704 Family description; Region: UvrD_C_2; pfam13538 1205910002705 Protein of unknown function (DUF419); Region: DUF419; pfam04237 1205910002706 NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530 1205910002707 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1205910002708 active site 1205910002709 metal binding site [ion binding]; metal-binding site 1205910002710 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1205910002711 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205910002712 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910002713 active site 1205910002714 phosphorylation site [posttranslational modification] 1205910002715 intermolecular recognition site; other site 1205910002716 dimerization interface [polypeptide binding]; other site 1205910002717 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205910002718 DNA binding site [nucleotide binding] 1205910002719 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1205910002720 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1205910002721 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1205910002722 dimer interface [polypeptide binding]; other site 1205910002723 phosphorylation site [posttranslational modification] 1205910002724 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910002725 ATP binding site [chemical binding]; other site 1205910002726 Mg2+ binding site [ion binding]; other site 1205910002727 G-X-G motif; other site 1205910002728 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1205910002729 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1205910002730 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1205910002731 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1205910002732 active site 1205910002733 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 1205910002734 homodimer interface [polypeptide binding]; other site 1205910002735 PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063 1205910002736 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1205910002737 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1205910002738 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1205910002739 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1205910002740 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1205910002741 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1205910002742 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 1205910002743 putative FMN binding site [chemical binding]; other site 1205910002744 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1205910002745 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1205910002746 active site 1205910002747 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1205910002748 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1205910002749 Glycerol-1-phosphate dehydrogenase-like; Region: G1PDH-like; cd08174 1205910002750 active site 1205910002751 metal binding site [ion binding]; metal-binding site 1205910002752 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1205910002753 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 1205910002754 active site 1205910002755 metal-binding site 1205910002756 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1205910002757 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1205910002758 Walker A/P-loop; other site 1205910002759 ATP binding site [chemical binding]; other site 1205910002760 Q-loop/lid; other site 1205910002761 ABC transporter signature motif; other site 1205910002762 Walker B; other site 1205910002763 D-loop; other site 1205910002764 H-loop/switch region; other site 1205910002765 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1205910002766 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1205910002767 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1205910002768 substrate binding site; other site 1205910002769 dimer interface; other site 1205910002770 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1205910002771 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 1205910002772 active site 1205910002773 metal binding site [ion binding]; metal-binding site 1205910002774 catalytic site [active] 1205910002775 Short C-terminal domain; Region: SHOCT; pfam09851 1205910002776 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 1205910002777 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1205910002778 Ligand binding site; other site 1205910002779 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 1205910002780 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1205910002781 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1205910002782 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1205910002783 NAD binding site [chemical binding]; other site 1205910002784 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1205910002785 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1205910002786 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 1205910002787 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1205910002788 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1205910002789 active site 1205910002790 metal binding site [ion binding]; metal-binding site 1205910002791 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1205910002792 active site 1205910002793 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1205910002794 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1205910002795 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910002796 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1205910002797 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1205910002798 AIR carboxylase; Region: AIRC; pfam00731 1205910002799 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1205910002800 ATP-grasp domain; Region: ATP-grasp; pfam02222 1205910002801 Predicted membrane protein [Function unknown]; Region: COG2246 1205910002802 GtrA-like protein; Region: GtrA; pfam04138 1205910002803 CAAX protease self-immunity; Region: Abi; pfam02517 1205910002804 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1205910002805 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1205910002806 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1205910002807 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1205910002808 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1205910002809 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1205910002810 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205910002811 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205910002812 DNA binding residues [nucleotide binding] 1205910002813 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910002814 S-adenosylmethionine binding site [chemical binding]; other site 1205910002815 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1205910002816 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1205910002817 interface (dimer of trimers) [polypeptide binding]; other site 1205910002818 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1205910002819 Substrate-binding/catalytic site; other site 1205910002820 Zn-binding sites [ion binding]; other site 1205910002821 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1205910002822 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1205910002823 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1205910002824 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1205910002825 metal binding site [ion binding]; metal-binding site 1205910002826 putative dimer interface [polypeptide binding]; other site 1205910002827 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1205910002828 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1205910002829 trimer interface [polypeptide binding]; other site 1205910002830 active site 1205910002831 substrate binding site [chemical binding]; other site 1205910002832 CoA binding site [chemical binding]; other site 1205910002833 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1205910002834 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205910002835 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910002836 homodimer interface [polypeptide binding]; other site 1205910002837 catalytic residue [active] 1205910002838 Ferredoxin [Energy production and conversion]; Region: COG1146 1205910002839 4Fe-4S binding domain; Region: Fer4; pfam00037 1205910002840 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1205910002841 Peptidase family M50; Region: Peptidase_M50; pfam02163 1205910002842 active site 1205910002843 putative substrate binding region [chemical binding]; other site 1205910002844 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 1205910002845 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1205910002846 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1205910002847 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1205910002848 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205910002849 active site 1205910002850 ATP binding site [chemical binding]; other site 1205910002851 substrate binding site [chemical binding]; other site 1205910002852 activation loop (A-loop); other site 1205910002853 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1205910002854 active site 1205910002855 ATP binding site [chemical binding]; other site 1205910002856 substrate binding site [chemical binding]; other site 1205910002857 activation loop (A-loop); other site 1205910002858 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205910002859 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205910002860 active site 1205910002861 ATP binding site [chemical binding]; other site 1205910002862 substrate binding site [chemical binding]; other site 1205910002863 activation loop (A-loop); other site 1205910002864 Protein kinase domain; Region: Pkinase; pfam00069 1205910002865 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205910002866 active site 1205910002867 ATP binding site [chemical binding]; other site 1205910002868 substrate binding site [chemical binding]; other site 1205910002869 activation loop (A-loop); other site 1205910002870 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1205910002871 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1205910002872 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1205910002873 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205910002874 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1205910002875 Coenzyme A binding pocket [chemical binding]; other site 1205910002876 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 1205910002877 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1205910002878 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1205910002879 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 1205910002880 L-aspartate oxidase; Provisional; Region: PRK06175 1205910002881 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1205910002882 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1205910002883 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 1205910002884 putative Iron-sulfur protein interface [polypeptide binding]; other site 1205910002885 proximal heme binding site [chemical binding]; other site 1205910002886 distal heme binding site [chemical binding]; other site 1205910002887 putative dimer interface [polypeptide binding]; other site 1205910002888 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1205910002889 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1205910002890 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1205910002891 dimerization interface [polypeptide binding]; other site 1205910002892 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1205910002893 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1205910002894 cyclase homology domain; Region: CHD; cd07302 1205910002895 nucleotidyl binding site; other site 1205910002896 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205910002897 metal binding site [ion binding]; metal-binding site 1205910002898 dimer interface [polypeptide binding]; other site 1205910002899 Bacterial PH domain; Region: DUF304; pfam03703 1205910002900 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1205910002901 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1205910002902 Sm and related proteins; Region: Sm_like; cd00600 1205910002903 Sm1 motif; other site 1205910002904 RNA binding site [nucleotide binding]; other site 1205910002905 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1205910002906 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 1205910002907 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1205910002908 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1205910002909 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1205910002910 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 1205910002911 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1205910002912 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1205910002913 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1205910002914 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1205910002915 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1205910002916 carboxyltransferase (CT) interaction site; other site 1205910002917 biotinylation site [posttranslational modification]; other site 1205910002918 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1205910002919 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1205910002920 AAA domain; Region: AAA_17; pfam13207 1205910002921 AAA domain; Region: AAA_18; pfam13238 1205910002922 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 1205910002923 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1205910002924 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205910002925 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205910002926 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1205910002927 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1205910002928 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1205910002929 adenosine deaminase; Provisional; Region: PRK09358 1205910002930 active site 1205910002931 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1205910002932 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1205910002933 metal binding site [ion binding]; metal-binding site 1205910002934 putative dimer interface [polypeptide binding]; other site 1205910002935 carboxylate-amine ligase; Provisional; Region: PRK13517 1205910002936 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1205910002937 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1205910002938 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1205910002939 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1205910002940 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1205910002941 isocitrate dehydrogenase; Validated; Region: PRK08299 1205910002942 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1205910002943 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1205910002944 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1205910002945 phosphopeptide binding site; other site 1205910002946 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1205910002947 DNA binding residues [nucleotide binding] 1205910002948 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1205910002949 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1205910002950 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1205910002951 homodimer interface [polypeptide binding]; other site 1205910002952 NADP binding site [chemical binding]; other site 1205910002953 substrate binding site [chemical binding]; other site 1205910002954 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1205910002955 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1205910002956 purine monophosphate binding site [chemical binding]; other site 1205910002957 dimer interface [polypeptide binding]; other site 1205910002958 putative catalytic residues [active] 1205910002959 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1205910002960 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1205910002961 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1205910002962 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1205910002963 active site 1205910002964 substrate binding site [chemical binding]; other site 1205910002965 cosubstrate binding site; other site 1205910002966 catalytic site [active] 1205910002967 Chain length determinant protein; Region: Wzz; cl15801 1205910002968 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1205910002969 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1205910002970 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1205910002971 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 1205910002972 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 1205910002973 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1205910002974 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1205910002975 active site 1205910002976 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1205910002977 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205910002978 Coenzyme A binding pocket [chemical binding]; other site 1205910002979 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 1205910002980 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1205910002981 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 1205910002982 calcium binding site 2 [ion binding]; other site 1205910002983 active site 1205910002984 catalytic triad [active] 1205910002985 calcium binding site 1 [ion binding]; other site 1205910002986 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 1205910002987 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1205910002988 CysD dimerization site [polypeptide binding]; other site 1205910002989 G1 box; other site 1205910002990 putative GEF interaction site [polypeptide binding]; other site 1205910002991 GTP/Mg2+ binding site [chemical binding]; other site 1205910002992 Switch I region; other site 1205910002993 G2 box; other site 1205910002994 G3 box; other site 1205910002995 Switch II region; other site 1205910002996 G4 box; other site 1205910002997 G5 box; other site 1205910002998 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1205910002999 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1205910003000 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1205910003001 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1205910003002 Active Sites [active] 1205910003003 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1205910003004 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1205910003005 active site 1205910003006 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1205910003007 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1205910003008 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1205910003009 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1205910003010 putative active site [active] 1205910003011 catalytic residue [active] 1205910003012 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1205910003013 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1205910003014 5S rRNA interface [nucleotide binding]; other site 1205910003015 CTC domain interface [polypeptide binding]; other site 1205910003016 L16 interface [polypeptide binding]; other site 1205910003017 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1205910003018 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1205910003019 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1205910003020 active site 1205910003021 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1205910003022 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1205910003023 Substrate binding site; other site 1205910003024 Mg++ binding site; other site 1205910003025 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1205910003026 active site 1205910003027 substrate binding site [chemical binding]; other site 1205910003028 CoA binding site [chemical binding]; other site 1205910003029 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1205910003030 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1205910003031 Di-iron ligands [ion binding]; other site 1205910003032 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910003033 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910003034 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1205910003035 active site 1205910003036 catalytic triad [active] 1205910003037 oxyanion hole [active] 1205910003038 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1205910003039 nucleotide binding site/active site [active] 1205910003040 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 1205910003041 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910003042 S-adenosylmethionine binding site [chemical binding]; other site 1205910003043 Helix-turn-helix domain; Region: HTH_31; pfam13560 1205910003044 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1205910003045 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1205910003046 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1205910003047 putative dimerization interface [polypeptide binding]; other site 1205910003048 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1205910003049 catalytic residues [active] 1205910003050 dimer interface [polypeptide binding]; other site 1205910003051 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205910003052 dimerization interface [polypeptide binding]; other site 1205910003053 putative DNA binding site [nucleotide binding]; other site 1205910003054 putative Zn2+ binding site [ion binding]; other site 1205910003055 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1205910003056 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1205910003057 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1205910003058 ABC transporter; Region: ABC_tran_2; pfam12848 1205910003059 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1205910003060 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1205910003061 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1205910003062 PYR/PP interface [polypeptide binding]; other site 1205910003063 dimer interface [polypeptide binding]; other site 1205910003064 TPP binding site [chemical binding]; other site 1205910003065 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1205910003066 TPP-binding site [chemical binding]; other site 1205910003067 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1205910003068 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205910003069 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205910003070 active site 1205910003071 ATP binding site [chemical binding]; other site 1205910003072 substrate binding site [chemical binding]; other site 1205910003073 activation loop (A-loop); other site 1205910003074 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1205910003075 GMP synthase; Reviewed; Region: guaA; PRK00074 1205910003076 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1205910003077 AMP/PPi binding site [chemical binding]; other site 1205910003078 candidate oxyanion hole; other site 1205910003079 catalytic triad [active] 1205910003080 potential glutamine specificity residues [chemical binding]; other site 1205910003081 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1205910003082 ATP Binding subdomain [chemical binding]; other site 1205910003083 Ligand Binding sites [chemical binding]; other site 1205910003084 Dimerization subdomain; other site 1205910003085 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 1205910003086 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1205910003087 generic binding surface I; other site 1205910003088 generic binding surface II; other site 1205910003089 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 1205910003090 putative active site [active] 1205910003091 putative catalytic site [active] 1205910003092 putative Mg binding site IVb [ion binding]; other site 1205910003093 putative phosphate binding site [ion binding]; other site 1205910003094 putative DNA binding site [nucleotide binding]; other site 1205910003095 putative Mg binding site IVa [ion binding]; other site 1205910003096 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 1205910003097 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 1205910003098 G1 box; other site 1205910003099 putative GEF interaction site [polypeptide binding]; other site 1205910003100 GTP/Mg2+ binding site [chemical binding]; other site 1205910003101 Switch I region; other site 1205910003102 G2 box; other site 1205910003103 G3 box; other site 1205910003104 Switch II region; other site 1205910003105 G4 box; other site 1205910003106 G5 box; other site 1205910003107 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1205910003108 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 1205910003109 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 1205910003110 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 1205910003111 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 1205910003112 active site 1205910003113 metal binding site [ion binding]; metal-binding site 1205910003114 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 1205910003115 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 1205910003116 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 1205910003117 DctM-like transporters; Region: DctM; pfam06808 1205910003118 Domain of unknown function (DUF1850); Region: DUF1850; pfam08905 1205910003119 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1205910003120 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1205910003121 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1205910003122 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1205910003123 dimerization interface [polypeptide binding]; other site 1205910003124 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1205910003125 dimer interface [polypeptide binding]; other site 1205910003126 phosphorylation site [posttranslational modification] 1205910003127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910003128 ATP binding site [chemical binding]; other site 1205910003129 Mg2+ binding site [ion binding]; other site 1205910003130 G-X-G motif; other site 1205910003131 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205910003132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910003133 active site 1205910003134 intermolecular recognition site; other site 1205910003135 dimerization interface [polypeptide binding]; other site 1205910003136 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205910003137 DNA binding site [nucleotide binding] 1205910003138 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1205910003139 Predicted transcriptional regulator [Transcription]; Region: COG2378 1205910003140 HTH domain; Region: HTH_11; pfam08279 1205910003141 WYL domain; Region: WYL; pfam13280 1205910003142 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 1205910003143 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 1205910003144 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1205910003145 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1205910003146 catalytic residue [active] 1205910003147 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1205910003148 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1205910003149 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1205910003150 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1205910003151 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1205910003152 active site 1205910003153 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1205910003154 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205910003155 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205910003156 DNA binding residues [nucleotide binding] 1205910003157 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1205910003158 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1205910003159 ring oligomerisation interface [polypeptide binding]; other site 1205910003160 ATP/Mg binding site [chemical binding]; other site 1205910003161 stacking interactions; other site 1205910003162 hinge regions; other site 1205910003163 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1205910003164 oligomerisation interface [polypeptide binding]; other site 1205910003165 mobile loop; other site 1205910003166 roof hairpin; other site 1205910003167 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910003168 S-adenosylmethionine binding site [chemical binding]; other site 1205910003169 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 1205910003170 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1205910003171 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1205910003172 NAD(P) binding site [chemical binding]; other site 1205910003173 tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723 1205910003174 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1205910003175 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1205910003176 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205910003177 Coenzyme A binding pocket [chemical binding]; other site 1205910003178 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1205910003179 Glycoprotease family; Region: Peptidase_M22; pfam00814 1205910003180 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1205910003181 alanine racemase; Reviewed; Region: alr; PRK00053 1205910003182 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1205910003183 active site 1205910003184 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1205910003185 dimer interface [polypeptide binding]; other site 1205910003186 substrate binding site [chemical binding]; other site 1205910003187 catalytic residues [active] 1205910003188 IncA protein; Region: IncA; pfam04156 1205910003189 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1205910003190 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1205910003191 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1205910003192 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1205910003193 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1205910003194 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1205910003195 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1205910003196 Walker A/P-loop; other site 1205910003197 ATP binding site [chemical binding]; other site 1205910003198 Q-loop/lid; other site 1205910003199 ABC transporter signature motif; other site 1205910003200 Walker B; other site 1205910003201 D-loop; other site 1205910003202 H-loop/switch region; other site 1205910003203 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1205910003204 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1205910003205 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1205910003206 TM-ABC transporter signature motif; other site 1205910003207 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1205910003208 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1205910003209 TM-ABC transporter signature motif; other site 1205910003210 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1205910003211 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1205910003212 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1205910003213 Trehalose utilisation; Region: ThuA; pfam06283 1205910003214 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1205910003215 FOG: PKD repeat [General function prediction only]; Region: COG3291 1205910003216 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1205910003217 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1205910003218 metal binding site [ion binding]; metal-binding site 1205910003219 ligand binding site [chemical binding]; other site 1205910003220 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1205910003221 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 1205910003222 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 1205910003223 UbiA prenyltransferase family; Region: UbiA; pfam01040 1205910003224 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1205910003225 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1205910003226 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1205910003227 TatD related DNase; Region: TatD_DNase; pfam01026 1205910003228 active site 1205910003229 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1205910003230 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 1205910003231 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1205910003232 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1205910003233 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1205910003234 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1205910003235 active site clefts [active] 1205910003236 zinc binding site [ion binding]; other site 1205910003237 dimer interface [polypeptide binding]; other site 1205910003238 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910003239 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910003240 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1205910003241 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1205910003242 GTPase RsgA; Reviewed; Region: PRK01889 1205910003243 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1205910003244 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1205910003245 GTP/Mg2+ binding site [chemical binding]; other site 1205910003246 G4 box; other site 1205910003247 G5 box; other site 1205910003248 G1 box; other site 1205910003249 Switch I region; other site 1205910003250 G2 box; other site 1205910003251 G3 box; other site 1205910003252 Switch II region; other site 1205910003253 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1205910003254 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1205910003255 active site 1205910003256 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205910003257 DNA-binding site [nucleotide binding]; DNA binding site 1205910003258 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1205910003259 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1205910003260 active site 1205910003261 HIGH motif; other site 1205910003262 KMSKS motif; other site 1205910003263 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1205910003264 tRNA binding surface [nucleotide binding]; other site 1205910003265 anticodon binding site; other site 1205910003266 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1205910003267 Protein export membrane protein; Region: SecD_SecF; cl14618 1205910003268 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1205910003269 Protein export membrane protein; Region: SecD_SecF; cl14618 1205910003270 Predicted methyltransferases [General function prediction only]; Region: COG0313 1205910003271 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1205910003272 putative SAM binding site [chemical binding]; other site 1205910003273 putative homodimer interface [polypeptide binding]; other site 1205910003274 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1205910003275 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1205910003276 DNA-binding site [nucleotide binding]; DNA binding site 1205910003277 RNA-binding motif; other site 1205910003278 sec-independent translocase; Provisional; Region: PRK01371 1205910003279 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910003280 WHG domain; Region: WHG; pfam13305 1205910003281 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1205910003282 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1205910003283 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1205910003284 MPT binding site; other site 1205910003285 trimer interface [polypeptide binding]; other site 1205910003286 molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364 1205910003287 trimer interface [polypeptide binding]; other site 1205910003288 dimer interface [polypeptide binding]; other site 1205910003289 putative active site [active] 1205910003290 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1205910003291 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1205910003292 dimer interface [polypeptide binding]; other site 1205910003293 putative functional site; other site 1205910003294 putative MPT binding site; other site 1205910003295 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 1205910003296 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1205910003297 active site 1205910003298 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1205910003299 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1205910003300 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1205910003301 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1205910003302 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1205910003303 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1205910003304 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1205910003305 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1205910003306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910003307 S-adenosylmethionine binding site [chemical binding]; other site 1205910003308 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1205910003309 PLD-like domain; Region: PLDc_2; pfam13091 1205910003310 putative active site [active] 1205910003311 catalytic site [active] 1205910003312 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1205910003313 PLD-like domain; Region: PLDc_2; pfam13091 1205910003314 putative active site [active] 1205910003315 catalytic site [active] 1205910003316 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1205910003317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910003318 S-adenosylmethionine binding site [chemical binding]; other site 1205910003319 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1205910003320 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1205910003321 coproporphyrinogen III oxidase; Validated; Region: PRK08208 1205910003322 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1205910003323 FeS/SAM binding site; other site 1205910003324 HemN C-terminal domain; Region: HemN_C; pfam06969 1205910003325 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205910003326 FeS/SAM binding site; other site 1205910003327 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205910003328 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1205910003329 active site 1205910003330 motif I; other site 1205910003331 motif II; other site 1205910003332 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1205910003333 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1205910003334 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1205910003335 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1205910003336 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1205910003337 Na binding site [ion binding]; other site 1205910003338 Histidine kinase; Region: His_kinase; pfam06580 1205910003339 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910003340 ATP binding site [chemical binding]; other site 1205910003341 Mg2+ binding site [ion binding]; other site 1205910003342 G-X-G motif; other site 1205910003343 LytTr DNA-binding domain; Region: LytTR; smart00850 1205910003344 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1205910003345 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1205910003346 Na binding site [ion binding]; other site 1205910003347 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 1205910003348 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1205910003349 active site 1205910003350 substrate-binding site [chemical binding]; other site 1205910003351 metal-binding site [ion binding] 1205910003352 GTP binding site [chemical binding]; other site 1205910003353 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205910003354 Ligand Binding Site [chemical binding]; other site 1205910003355 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 1205910003356 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1205910003357 Part of AAA domain; Region: AAA_19; pfam13245 1205910003358 Family description; Region: UvrD_C_2; pfam13538 1205910003359 pantothenate kinase; Provisional; Region: PRK05439 1205910003360 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1205910003361 ATP-binding site [chemical binding]; other site 1205910003362 CoA-binding site [chemical binding]; other site 1205910003363 Mg2+-binding site [ion binding]; other site 1205910003364 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 1205910003365 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1205910003366 glutaminase active site [active] 1205910003367 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1205910003368 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1205910003369 dimer interface [polypeptide binding]; other site 1205910003370 active site 1205910003371 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1205910003372 dimer interface [polypeptide binding]; other site 1205910003373 active site 1205910003374 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1205910003375 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1205910003376 anti sigma factor interaction site; other site 1205910003377 regulatory phosphorylation site [posttranslational modification]; other site 1205910003378 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1205910003379 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1205910003380 ATP binding site [chemical binding]; other site 1205910003381 Mg2+ binding site [ion binding]; other site 1205910003382 G-X-G motif; other site 1205910003383 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910003384 non-specific DNA binding site [nucleotide binding]; other site 1205910003385 salt bridge; other site 1205910003386 sequence-specific DNA binding site [nucleotide binding]; other site 1205910003387 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1205910003388 C2 domain; Region: C2; cl14603 1205910003389 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205910003390 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1205910003391 FeS/SAM binding site; other site 1205910003392 putative phosphate acyltransferase; Provisional; Region: PRK05331 1205910003393 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1205910003394 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1205910003395 arginine-tRNA ligase; Region: PLN02286 1205910003396 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1205910003397 active site 1205910003398 HIGH motif; other site 1205910003399 KMSK motif region; other site 1205910003400 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1205910003401 tRNA binding surface [nucleotide binding]; other site 1205910003402 anticodon binding site; other site 1205910003403 YceI-like domain; Region: YceI; pfam04264 1205910003404 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1205910003405 substrate binding site [chemical binding]; other site 1205910003406 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1205910003407 ATP binding site [chemical binding]; other site 1205910003408 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1205910003409 active site 1205910003410 metal binding site A [ion binding]; metal-binding site 1205910003411 DNA binding site [nucleotide binding] 1205910003412 putative catalytic site [active] 1205910003413 putative phosphate binding site [ion binding]; other site 1205910003414 putative AP binding site [nucleotide binding]; other site 1205910003415 putative metal binding site B [ion binding]; other site 1205910003416 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1205910003417 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1205910003418 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1205910003419 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1205910003420 dimer interface [polypeptide binding]; other site 1205910003421 active site 1205910003422 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1205910003423 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910003424 putative substrate translocation pore; other site 1205910003425 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1205910003426 MarR family; Region: MarR_2; pfam12802 1205910003427 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205910003428 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205910003429 active site 1205910003430 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1205910003431 PAS fold; Region: PAS_3; pfam08447 1205910003432 putative active site [active] 1205910003433 heme pocket [chemical binding]; other site 1205910003434 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1205910003435 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1205910003436 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1205910003437 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1205910003438 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1205910003439 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1205910003440 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1205910003441 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1205910003442 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 1205910003443 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1205910003444 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1205910003445 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1205910003446 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1205910003447 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1205910003448 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205910003449 catalytic residue [active] 1205910003450 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1205910003451 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1205910003452 active site 1205910003453 catalytic site [active] 1205910003454 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 1205910003455 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 1205910003456 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1205910003457 DNA binding residues [nucleotide binding] 1205910003458 putative dimer interface [polypeptide binding]; other site 1205910003459 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1205910003460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910003461 putative substrate translocation pore; other site 1205910003462 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1205910003463 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1205910003464 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1205910003465 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1205910003466 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1205910003467 H+ Antiporter protein; Region: 2A0121; TIGR00900 1205910003468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910003469 putative substrate translocation pore; other site 1205910003470 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1205910003471 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1205910003472 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1205910003473 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910003474 S-adenosylmethionine binding site [chemical binding]; other site 1205910003475 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1205910003476 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1205910003477 MOSC domain; Region: MOSC; pfam03473 1205910003478 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1205910003479 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1205910003480 DNA-binding site [nucleotide binding]; DNA binding site 1205910003481 RNA-binding motif; other site 1205910003482 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1205910003483 WYL domain; Region: WYL; pfam13280 1205910003484 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1205910003485 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1205910003486 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1205910003487 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205910003488 ATP binding site [chemical binding]; other site 1205910003489 putative Mg++ binding site [ion binding]; other site 1205910003490 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205910003491 nucleotide binding region [chemical binding]; other site 1205910003492 ATP-binding site [chemical binding]; other site 1205910003493 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 1205910003494 active site 1205910003495 diiron metal binding site [ion binding]; other site 1205910003496 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 1205910003497 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 1205910003498 Scramblase; Region: Scramblase; pfam03803 1205910003499 Zeta toxin; Region: Zeta_toxin; pfam06414 1205910003500 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910003501 Walker A/P-loop; other site 1205910003502 ATP binding site [chemical binding]; other site 1205910003503 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1205910003504 nudix motif; other site 1205910003505 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1205910003506 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1205910003507 CAAX protease self-immunity; Region: Abi; pfam02517 1205910003508 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1205910003509 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1205910003510 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910003511 Q-loop/lid; other site 1205910003512 ABC transporter signature motif; other site 1205910003513 Walker B; other site 1205910003514 D-loop; other site 1205910003515 H-loop/switch region; other site 1205910003516 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1205910003517 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1205910003518 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910003519 Walker A/P-loop; other site 1205910003520 ATP binding site [chemical binding]; other site 1205910003521 Q-loop/lid; other site 1205910003522 ABC transporter signature motif; other site 1205910003523 Walker B; other site 1205910003524 D-loop; other site 1205910003525 H-loop/switch region; other site 1205910003526 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1205910003527 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910003528 S-adenosylmethionine binding site [chemical binding]; other site 1205910003529 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1205910003530 nudix motif; other site 1205910003531 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 1205910003532 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1205910003533 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1205910003534 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1205910003535 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1205910003536 ring oligomerisation interface [polypeptide binding]; other site 1205910003537 ATP/Mg binding site [chemical binding]; other site 1205910003538 stacking interactions; other site 1205910003539 hinge regions; other site 1205910003540 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1205910003541 MoaE interaction surface [polypeptide binding]; other site 1205910003542 MoeB interaction surface [polypeptide binding]; other site 1205910003543 thiocarboxylated glycine; other site 1205910003544 threonine synthase; Validated; Region: PRK07591 1205910003545 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1205910003546 homodimer interface [polypeptide binding]; other site 1205910003547 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910003548 catalytic residue [active] 1205910003549 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1205910003550 Glycosyltransferase family 20; Region: Glyco_transf_20; pfam00982 1205910003551 active site 1205910003552 homotetramer interface [polypeptide binding]; other site 1205910003553 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1205910003554 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1205910003555 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1205910003556 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 1205910003557 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1205910003558 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205910003559 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205910003560 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1205910003561 heterotetramer interface [polypeptide binding]; other site 1205910003562 active site pocket [active] 1205910003563 cleavage site 1205910003564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910003565 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1205910003566 putative substrate translocation pore; other site 1205910003567 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910003568 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1205910003569 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910003570 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1205910003571 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1205910003572 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1205910003573 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1205910003574 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1205910003575 dimerization domain swap beta strand [polypeptide binding]; other site 1205910003576 regulatory protein interface [polypeptide binding]; other site 1205910003577 active site 1205910003578 regulatory phosphorylation site [posttranslational modification]; other site 1205910003579 AMP-binding domain protein; Validated; Region: PRK08315 1205910003580 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205910003581 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1205910003582 acyl-activating enzyme (AAE) consensus motif; other site 1205910003583 acyl-activating enzyme (AAE) consensus motif; other site 1205910003584 putative AMP binding site [chemical binding]; other site 1205910003585 putative active site [active] 1205910003586 putative CoA binding site [chemical binding]; other site 1205910003587 RibD C-terminal domain; Region: RibD_C; cl17279 1205910003588 RibD C-terminal domain; Region: RibD_C; cl17279 1205910003589 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1205910003590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910003591 metabolite-proton symporter; Region: 2A0106; TIGR00883 1205910003592 putative substrate translocation pore; other site 1205910003593 acetylornithine deacetylase; Provisional; Region: PRK06837 1205910003594 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 1205910003595 metal binding site [ion binding]; metal-binding site 1205910003596 dimer interface [polypeptide binding]; other site 1205910003597 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1205910003598 catalytic residues [active] 1205910003599 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1205910003600 DNA binding residues [nucleotide binding] 1205910003601 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1205910003602 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910003603 non-specific DNA binding site [nucleotide binding]; other site 1205910003604 salt bridge; other site 1205910003605 sequence-specific DNA binding site [nucleotide binding]; other site 1205910003606 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1205910003607 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1205910003608 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1205910003609 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910003610 non-specific DNA binding site [nucleotide binding]; other site 1205910003611 salt bridge; other site 1205910003612 sequence-specific DNA binding site [nucleotide binding]; other site 1205910003613 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1205910003614 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1205910003615 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1205910003616 putative NAD(P) binding site [chemical binding]; other site 1205910003617 Phosphotransferase enzyme family; Region: APH; pfam01636 1205910003618 HD domain; Region: HD_3; cl17350 1205910003619 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1205910003620 nudix motif; other site 1205910003621 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1205910003622 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 1205910003623 homodimer interface [polypeptide binding]; other site 1205910003624 chemical substrate binding site [chemical binding]; other site 1205910003625 oligomer interface [polypeptide binding]; other site 1205910003626 metal binding site [ion binding]; metal-binding site 1205910003627 Fic family protein [Function unknown]; Region: COG3177 1205910003628 Fic/DOC family; Region: Fic; pfam02661 1205910003629 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1205910003630 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1205910003631 TPR motif; other site 1205910003632 binding surface 1205910003633 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1205910003634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910003635 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1205910003636 putative substrate translocation pore; other site 1205910003637 Nitronate monooxygenase; Region: NMO; pfam03060 1205910003638 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1205910003639 FMN binding site [chemical binding]; other site 1205910003640 substrate binding site [chemical binding]; other site 1205910003641 putative catalytic residue [active] 1205910003642 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 1205910003643 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1205910003644 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 1205910003645 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1205910003646 intersubunit interface [polypeptide binding]; other site 1205910003647 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1205910003648 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1205910003649 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1205910003650 active site 1205910003651 short chain dehydrogenase; Provisional; Region: PRK06197 1205910003652 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1205910003653 putative NAD(P) binding site [chemical binding]; other site 1205910003654 active site 1205910003655 LysE type translocator; Region: LysE; cl00565 1205910003656 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1205910003657 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1205910003658 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1205910003659 homodimer interface [polypeptide binding]; other site 1205910003660 active site 1205910003661 TDP-binding site; other site 1205910003662 acceptor substrate-binding pocket; other site 1205910003663 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 1205910003664 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 1205910003665 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1205910003666 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1205910003667 inhibitor-cofactor binding pocket; inhibition site 1205910003668 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910003669 catalytic residue [active] 1205910003670 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1205910003671 homodimer interface [polypeptide binding]; other site 1205910003672 active site 1205910003673 TDP-binding site; other site 1205910003674 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1205910003675 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1205910003676 homodimer interface [polypeptide binding]; other site 1205910003677 active site 1205910003678 TDP-binding site; other site 1205910003679 acceptor substrate-binding pocket; other site 1205910003680 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 1205910003681 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1205910003682 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1205910003683 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1205910003684 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1205910003685 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205910003686 NAD(P) binding site [chemical binding]; other site 1205910003687 active site 1205910003688 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 1205910003689 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1205910003690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910003691 S-adenosylmethionine binding site [chemical binding]; other site 1205910003692 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 1205910003693 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1205910003694 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1205910003695 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1205910003696 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1205910003697 active site 1205910003698 ATP binding site [chemical binding]; other site 1205910003699 substrate binding site [chemical binding]; other site 1205910003700 activation loop (A-loop); other site 1205910003701 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1205910003702 active site 1205910003703 zinc binding site [ion binding]; other site 1205910003704 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1205910003705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910003706 S-adenosylmethionine binding site [chemical binding]; other site 1205910003707 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1205910003708 active sites [active] 1205910003709 tetramer interface [polypeptide binding]; other site 1205910003710 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205910003711 AMP binding site [chemical binding]; other site 1205910003712 active site 1205910003713 acyl-activating enzyme (AAE) consensus motif; other site 1205910003714 CoA binding site [chemical binding]; other site 1205910003715 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1205910003716 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1205910003717 NAD binding site [chemical binding]; other site 1205910003718 substrate binding site [chemical binding]; other site 1205910003719 homodimer interface [polypeptide binding]; other site 1205910003720 active site 1205910003721 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1205910003722 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1205910003723 active site 1205910003724 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1205910003725 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1205910003726 active site 1205910003727 TDP-binding site; other site 1205910003728 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1205910003729 active site 1205910003730 TDP-binding site; other site 1205910003731 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910003732 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1205910003733 Walker A/P-loop; other site 1205910003734 ATP binding site [chemical binding]; other site 1205910003735 Q-loop/lid; other site 1205910003736 ABC transporter signature motif; other site 1205910003737 Walker B; other site 1205910003738 D-loop; other site 1205910003739 H-loop/switch region; other site 1205910003740 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1205910003741 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1205910003742 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205910003743 NAD(P) binding site [chemical binding]; other site 1205910003744 active site 1205910003745 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1205910003746 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 1205910003747 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1205910003748 inhibitor-cofactor binding pocket; inhibition site 1205910003749 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910003750 catalytic residue [active] 1205910003751 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 1205910003752 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1205910003753 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1205910003754 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1205910003755 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1205910003756 active site 1205910003757 TDP-binding site; other site 1205910003758 acceptor substrate-binding pocket; other site 1205910003759 homodimer interface [polypeptide binding]; other site 1205910003760 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1205910003761 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1205910003762 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1205910003763 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1205910003764 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1205910003765 homodimer interface [polypeptide binding]; other site 1205910003766 active site 1205910003767 TDP-binding site; other site 1205910003768 acceptor substrate-binding pocket; other site 1205910003769 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1205910003770 homodimer interface [polypeptide binding]; other site 1205910003771 active site 1205910003772 TDP-binding site; other site 1205910003773 acceptor substrate-binding pocket; other site 1205910003774 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1205910003775 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910003776 Walker A/P-loop; other site 1205910003777 ATP binding site [chemical binding]; other site 1205910003778 Q-loop/lid; other site 1205910003779 ABC transporter signature motif; other site 1205910003780 Walker B; other site 1205910003781 D-loop; other site 1205910003782 H-loop/switch region; other site 1205910003783 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1205910003784 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1205910003785 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1205910003786 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1205910003787 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1205910003788 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1205910003789 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1205910003790 Thioredoxin; Region: Thioredoxin_4; pfam13462 1205910003791 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1205910003792 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 1205910003793 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1205910003794 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1205910003795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910003796 S-adenosylmethionine binding site [chemical binding]; other site 1205910003797 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205910003798 Cytochrome P450; Region: p450; cl12078 1205910003799 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205910003800 Cytochrome P450; Region: p450; cl12078 1205910003801 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1205910003802 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1205910003803 G1 box; other site 1205910003804 GTP/Mg2+ binding site [chemical binding]; other site 1205910003805 G2 box; other site 1205910003806 Switch I region; other site 1205910003807 G3 box; other site 1205910003808 Switch II region; other site 1205910003809 G4 box; other site 1205910003810 G5 box; other site 1205910003811 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1205910003812 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 1205910003813 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1205910003814 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910003815 ATP binding site [chemical binding]; other site 1205910003816 Mg2+ binding site [ion binding]; other site 1205910003817 G-X-G motif; other site 1205910003818 hypothetical protein; Provisional; Region: PRK06185 1205910003819 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205910003820 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1205910003821 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910003822 sequence-specific DNA binding site [nucleotide binding]; other site 1205910003823 salt bridge; other site 1205910003824 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1205910003825 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1205910003826 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1205910003827 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1205910003828 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1205910003829 active site 1205910003830 HIGH motif; other site 1205910003831 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1205910003832 KMSKS motif; other site 1205910003833 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1205910003834 tRNA binding surface [nucleotide binding]; other site 1205910003835 anticodon binding site; other site 1205910003836 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 1205910003837 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1205910003838 homotrimer interaction site [polypeptide binding]; other site 1205910003839 zinc binding site [ion binding]; other site 1205910003840 CDP-binding sites; other site 1205910003841 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1205910003842 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1205910003843 PhoU domain; Region: PhoU; pfam01895 1205910003844 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1205910003845 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1205910003846 dimer interface [polypeptide binding]; other site 1205910003847 phosphorylation site [posttranslational modification] 1205910003848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910003849 ATP binding site [chemical binding]; other site 1205910003850 Mg2+ binding site [ion binding]; other site 1205910003851 G-X-G motif; other site 1205910003852 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205910003853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910003854 active site 1205910003855 phosphorylation site [posttranslational modification] 1205910003856 intermolecular recognition site; other site 1205910003857 dimerization interface [polypeptide binding]; other site 1205910003858 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205910003859 DNA binding site [nucleotide binding] 1205910003860 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1205910003861 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205910003862 DNA-binding site [nucleotide binding]; DNA binding site 1205910003863 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205910003864 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910003865 homodimer interface [polypeptide binding]; other site 1205910003866 catalytic residue [active] 1205910003867 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1205910003868 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1205910003869 putative active site [active] 1205910003870 dimerization interface [polypeptide binding]; other site 1205910003871 putative tRNAtyr binding site [nucleotide binding]; other site 1205910003872 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1205910003873 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1205910003874 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 1205910003875 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1205910003876 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1205910003877 DNA photolyase; Region: DNA_photolyase; pfam00875 1205910003878 Protein of unknown function (DUF523); Region: DUF523; pfam04463 1205910003879 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1205910003880 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 1205910003881 Putative esterase; Region: Esterase; pfam00756 1205910003882 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1205910003883 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1205910003884 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1205910003885 putative ADP-binding pocket [chemical binding]; other site 1205910003886 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1205910003887 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205910003888 catalytic core [active] 1205910003889 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1205910003890 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 1205910003891 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1205910003892 heme-binding site [chemical binding]; other site 1205910003893 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1205910003894 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1205910003895 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1205910003896 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1205910003897 catalytic triad [active] 1205910003898 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1205910003899 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1205910003900 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1205910003901 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 1205910003902 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1205910003903 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1205910003904 active site residue [active] 1205910003905 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1205910003906 active site residue [active] 1205910003907 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1205910003908 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1205910003909 catalytic residues [active] 1205910003910 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1205910003911 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1205910003912 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1205910003913 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1205910003914 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205910003915 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1205910003916 NAD(P) binding site [chemical binding]; other site 1205910003917 active site 1205910003918 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1205910003919 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205910003920 catalytic core [active] 1205910003921 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1205910003922 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1205910003923 inhibitor-cofactor binding pocket; inhibition site 1205910003924 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910003925 catalytic residue [active] 1205910003926 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1205910003927 active site 1205910003928 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1205910003929 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1205910003930 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910003931 Walker A/P-loop; other site 1205910003932 ATP binding site [chemical binding]; other site 1205910003933 Q-loop/lid; other site 1205910003934 ABC transporter signature motif; other site 1205910003935 Walker B; other site 1205910003936 D-loop; other site 1205910003937 H-loop/switch region; other site 1205910003938 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1205910003939 Histidine kinase; Region: HisKA_3; pfam07730 1205910003940 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910003941 ATP binding site [chemical binding]; other site 1205910003942 Mg2+ binding site [ion binding]; other site 1205910003943 G-X-G motif; other site 1205910003944 Response regulator receiver domain; Region: Response_reg; pfam00072 1205910003945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910003946 active site 1205910003947 phosphorylation site [posttranslational modification] 1205910003948 intermolecular recognition site; other site 1205910003949 dimerization interface [polypeptide binding]; other site 1205910003950 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205910003951 DNA binding residues [nucleotide binding] 1205910003952 Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; smart00943 1205910003953 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1205910003954 dimer interface [polypeptide binding]; other site 1205910003955 active site 1205910003956 Schiff base residues; other site 1205910003957 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1205910003958 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1205910003959 domain interfaces; other site 1205910003960 active site 1205910003961 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1205910003962 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1205910003963 tRNA; other site 1205910003964 putative tRNA binding site [nucleotide binding]; other site 1205910003965 putative NADP binding site [chemical binding]; other site 1205910003966 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1205910003967 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1205910003968 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1205910003969 CoA binding domain; Region: CoA_binding; smart00881 1205910003970 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1205910003971 Ubiquitin-like proteins; Region: UBQ; cl00155 1205910003972 charged pocket; other site 1205910003973 hydrophobic patch; other site 1205910003974 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205910003975 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205910003976 DNA binding site [nucleotide binding] 1205910003977 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1205910003978 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205910003979 Coenzyme A binding pocket [chemical binding]; other site 1205910003980 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1205910003981 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1205910003982 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910003983 dimer interface [polypeptide binding]; other site 1205910003984 conserved gate region; other site 1205910003985 putative PBP binding loops; other site 1205910003986 ABC-ATPase subunit interface; other site 1205910003987 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1205910003988 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910003989 dimer interface [polypeptide binding]; other site 1205910003990 conserved gate region; other site 1205910003991 putative PBP binding loops; other site 1205910003992 ABC-ATPase subunit interface; other site 1205910003993 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1205910003994 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1205910003995 Walker A/P-loop; other site 1205910003996 ATP binding site [chemical binding]; other site 1205910003997 Q-loop/lid; other site 1205910003998 ABC transporter signature motif; other site 1205910003999 Walker B; other site 1205910004000 D-loop; other site 1205910004001 H-loop/switch region; other site 1205910004002 nuc_hydro_CeIAG: Nucleoside hydrolases similar to the inosine-adenosine-guanosine-preferring nucleoside hydrolase from Caenorhabditis elegans. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_CeIAG; cd02649 1205910004003 active site 1205910004004 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1205910004005 CoenzymeA binding site [chemical binding]; other site 1205910004006 subunit interaction site [polypeptide binding]; other site 1205910004007 PHB binding site; other site 1205910004008 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1205910004009 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1205910004010 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1205910004011 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205910004012 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205910004013 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1205910004014 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1205910004015 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1205910004016 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1205910004017 active site 1205910004018 tetramer interface [polypeptide binding]; other site 1205910004019 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1205910004020 active site 1205910004021 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1205910004022 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1205910004023 dimerization interface [polypeptide binding]; other site 1205910004024 putative ATP binding site [chemical binding]; other site 1205910004025 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1205910004026 DNA binding residues [nucleotide binding] 1205910004027 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1205910004028 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1205910004029 active site 1205910004030 metal binding site [ion binding]; metal-binding site 1205910004031 DivIVA domain; Region: DivI1A_domain; TIGR03544 1205910004032 DivIVA domain; Region: DivI1A_domain; TIGR03544 1205910004033 DivIVA domain; Region: DivI1A_domain; TIGR03544 1205910004034 DivIVA domain; Region: DivI1A_domain; TIGR03544 1205910004035 Peptidase family M48; Region: Peptidase_M48; cl12018 1205910004036 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 1205910004037 nudix motif; other site 1205910004038 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1205910004039 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 1205910004040 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1205910004041 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1205910004042 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1205910004043 anti sigma factor interaction site; other site 1205910004044 regulatory phosphorylation site [posttranslational modification]; other site 1205910004045 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1205910004046 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1205910004047 Walker A; other site 1205910004048 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1205910004049 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1205910004050 active site 1205910004051 substrate binding site [chemical binding]; other site 1205910004052 coenzyme B12 binding site [chemical binding]; other site 1205910004053 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1205910004054 B12 binding site [chemical binding]; other site 1205910004055 cobalt ligand [ion binding]; other site 1205910004056 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1205910004057 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1205910004058 heterodimer interface [polypeptide binding]; other site 1205910004059 substrate interaction site [chemical binding]; other site 1205910004060 Protein kinase domain; Region: Pkinase; pfam00069 1205910004061 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205910004062 active site 1205910004063 ATP binding site [chemical binding]; other site 1205910004064 substrate binding site [chemical binding]; other site 1205910004065 activation loop (A-loop); other site 1205910004066 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1205910004067 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205910004068 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205910004069 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1205910004070 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1205910004071 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1205910004072 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1205910004073 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 1205910004074 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 1205910004075 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1205910004076 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1205910004077 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1205910004078 active site 1205910004079 putative substrate binding pocket [chemical binding]; other site 1205910004080 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1205910004081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910004082 S-adenosylmethionine binding site [chemical binding]; other site 1205910004083 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910004084 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910004085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910004086 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1205910004087 putative substrate translocation pore; other site 1205910004088 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205910004089 Coenzyme A binding pocket [chemical binding]; other site 1205910004090 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1205910004091 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1205910004092 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1205910004093 trimer interface [polypeptide binding]; other site 1205910004094 putative metal binding site [ion binding]; other site 1205910004095 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1205910004096 Histidine kinase; Region: HisKA_3; pfam07730 1205910004097 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1205910004098 Histidine kinase; Region: HisKA_3; pfam07730 1205910004099 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1205910004100 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1205910004101 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1205910004102 Walker A/P-loop; other site 1205910004103 ATP binding site [chemical binding]; other site 1205910004104 Q-loop/lid; other site 1205910004105 ABC transporter signature motif; other site 1205910004106 Walker B; other site 1205910004107 D-loop; other site 1205910004108 H-loop/switch region; other site 1205910004109 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1205910004110 4Fe-4S binding domain; Region: Fer4; cl02805 1205910004111 4Fe-4S binding domain; Region: Fer4; pfam00037 1205910004112 Cysteine-rich domain; Region: CCG; pfam02754 1205910004113 Cysteine-rich domain; Region: CCG; pfam02754 1205910004114 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1205910004115 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1205910004116 nucleotide binding site [chemical binding]; other site 1205910004117 NEF interaction site [polypeptide binding]; other site 1205910004118 SBD interface [polypeptide binding]; other site 1205910004119 GrpE; Region: GrpE; pfam01025 1205910004120 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1205910004121 dimer interface [polypeptide binding]; other site 1205910004122 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1205910004123 chaperone protein DnaJ; Provisional; Region: PRK14295 1205910004124 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1205910004125 HSP70 interaction site [polypeptide binding]; other site 1205910004126 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1205910004127 Zn binding sites [ion binding]; other site 1205910004128 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1205910004129 dimer interface [polypeptide binding]; other site 1205910004130 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1205910004131 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1205910004132 DNA binding residues [nucleotide binding] 1205910004133 putative dimer interface [polypeptide binding]; other site 1205910004134 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1205910004135 Clp amino terminal domain; Region: Clp_N; pfam02861 1205910004136 Clp amino terminal domain; Region: Clp_N; pfam02861 1205910004137 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205910004138 Walker A motif; other site 1205910004139 ATP binding site [chemical binding]; other site 1205910004140 Walker B motif; other site 1205910004141 arginine finger; other site 1205910004142 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205910004143 Walker A motif; other site 1205910004144 ATP binding site [chemical binding]; other site 1205910004145 Walker B motif; other site 1205910004146 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1205910004147 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1205910004148 putative active site [active] 1205910004149 Interferon-induced transmembrane protein; Region: CD225; pfam04505 1205910004150 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205910004151 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1205910004152 NAD(P) binding site [chemical binding]; other site 1205910004153 active site 1205910004154 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1205910004155 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205910004156 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1205910004157 DNA binding residues [nucleotide binding] 1205910004158 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1205910004159 H+ Antiporter protein; Region: 2A0121; TIGR00900 1205910004160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1205910004161 Condensation domain; Region: Condensation; pfam00668 1205910004162 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1205910004163 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1205910004164 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1205910004165 acyl-activating enzyme (AAE) consensus motif; other site 1205910004166 AMP binding site [chemical binding]; other site 1205910004167 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205910004168 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1205910004169 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1205910004170 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1205910004171 acyl-activating enzyme (AAE) consensus motif; other site 1205910004172 AMP binding site [chemical binding]; other site 1205910004173 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205910004174 Condensation domain; Region: Condensation; pfam00668 1205910004175 Condensation domain; Region: Condensation; pfam00668 1205910004176 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1205910004177 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1205910004178 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1205910004179 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1205910004180 acyl-activating enzyme (AAE) consensus motif; other site 1205910004181 AMP binding site [chemical binding]; other site 1205910004182 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205910004183 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1205910004184 Thioesterase domain; Region: Thioesterase; pfam00975 1205910004185 potential frameshift: common BLAST hit: gi|384176792|ref|YP_005558177.1| amino acid adenylation domain protein 1205910004186 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1205910004187 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205910004188 Condensation domain; Region: Condensation; pfam00668 1205910004189 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1205910004190 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1205910004191 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1205910004192 acyl-activating enzyme (AAE) consensus motif; other site 1205910004193 AMP binding site [chemical binding]; other site 1205910004194 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205910004195 Condensation domain; Region: Condensation; pfam00668 1205910004196 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1205910004197 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205910004198 acyl-activating enzyme (AAE) consensus motif; other site 1205910004199 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1205910004200 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1205910004201 asparagine synthetase A; Reviewed; Region: PRK06462 1205910004202 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1205910004203 motif 1; other site 1205910004204 dimer interface [polypeptide binding]; other site 1205910004205 active site 1205910004206 motif 2; other site 1205910004207 motif 3; other site 1205910004208 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cl02025 1205910004209 substrate binding site [chemical binding]; other site 1205910004210 B12 cofactor binding site [chemical binding]; other site 1205910004211 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 1205910004212 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 1205910004213 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1205910004214 B12 binding site [chemical binding]; other site 1205910004215 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1205910004216 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910004217 non-specific DNA binding site [nucleotide binding]; other site 1205910004218 salt bridge; other site 1205910004219 sequence-specific DNA binding site [nucleotide binding]; other site 1205910004220 AAA ATPase domain; Region: AAA_16; pfam13191 1205910004221 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1205910004222 DNA binding site [nucleotide binding] 1205910004223 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1205910004224 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1205910004225 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1205910004226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1205910004227 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1205910004228 ATPase involved in DNA repair; Region: DUF3686; pfam12458 1205910004229 AAA domain; Region: AAA_22; pfam13401 1205910004230 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205910004231 Walker A motif; other site 1205910004232 ATP binding site [chemical binding]; other site 1205910004233 Walker B motif; other site 1205910004234 arginine finger; other site 1205910004235 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1205910004236 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1205910004237 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1205910004238 active site 1205910004239 catalytic tetrad [active] 1205910004240 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1205910004241 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1205910004242 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1205910004243 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1205910004244 Walker A/P-loop; other site 1205910004245 ATP binding site [chemical binding]; other site 1205910004246 Q-loop/lid; other site 1205910004247 ABC transporter signature motif; other site 1205910004248 Walker B; other site 1205910004249 D-loop; other site 1205910004250 H-loop/switch region; other site 1205910004251 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1205910004252 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1205910004253 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 1205910004254 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 1205910004255 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 1205910004256 YcaO-like family; Region: YcaO; pfam02624 1205910004257 SpaB C-terminal domain; Region: SpaB_C; pfam14028 1205910004258 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1205910004259 putative FMN binding site [chemical binding]; other site 1205910004260 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1205910004261 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1205910004262 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 1205910004263 FAD binding site [chemical binding]; other site 1205910004264 substrate binding site [chemical binding]; other site 1205910004265 catalytic residues [active] 1205910004266 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1205910004267 Septum formation; Region: Septum_form; pfam13845 1205910004268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910004269 putative substrate translocation pore; other site 1205910004270 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1205910004271 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1205910004272 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205910004273 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1205910004274 active site 1205910004275 ATP binding site [chemical binding]; other site 1205910004276 substrate binding site [chemical binding]; other site 1205910004277 activation loop (A-loop); other site 1205910004278 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205910004279 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205910004280 active site 1205910004281 ATP binding site [chemical binding]; other site 1205910004282 substrate binding site [chemical binding]; other site 1205910004283 activation loop (A-loop); other site 1205910004284 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1205910004285 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1205910004286 structural tetrad; other site 1205910004287 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1205910004288 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205910004289 active site 1205910004290 ATP binding site [chemical binding]; other site 1205910004291 substrate binding site [chemical binding]; other site 1205910004292 activation loop (A-loop); other site 1205910004293 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1205910004294 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1205910004295 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1205910004296 structural tetrad; other site 1205910004297 Protein kinase domain; Region: Pkinase; pfam00069 1205910004298 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1205910004299 active site 1205910004300 ATP binding site [chemical binding]; other site 1205910004301 substrate binding site [chemical binding]; other site 1205910004302 activation loop (A-loop); other site 1205910004303 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1205910004304 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1205910004305 structural tetrad; other site 1205910004306 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1205910004307 structural tetrad; other site 1205910004308 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1205910004309 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205910004310 active site 1205910004311 ATP binding site [chemical binding]; other site 1205910004312 substrate binding site [chemical binding]; other site 1205910004313 activation loop (A-loop); other site 1205910004314 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1205910004315 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1205910004316 structural tetrad; other site 1205910004317 Protein kinase domain; Region: Pkinase; pfam00069 1205910004318 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1205910004319 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1205910004320 structural tetrad; other site 1205910004321 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205910004322 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205910004323 active site 1205910004324 ATP binding site [chemical binding]; other site 1205910004325 substrate binding site [chemical binding]; other site 1205910004326 activation loop (A-loop); other site 1205910004327 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1205910004328 structural tetrad; other site 1205910004329 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1205910004330 PQQ-like domain; Region: PQQ_2; pfam13360 1205910004331 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1205910004332 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1205910004333 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1205910004334 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1205910004335 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1205910004336 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1205910004337 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205910004338 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1205910004339 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205910004340 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205910004341 Eukaryotic cytochrome b(561); Region: Cyt_b561; cl14616 1205910004342 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1205910004343 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1205910004344 active site 1205910004345 ATP binding site [chemical binding]; other site 1205910004346 substrate binding site [chemical binding]; other site 1205910004347 activation loop (A-loop); other site 1205910004348 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 1205910004349 trimer interface [polypeptide binding]; other site 1205910004350 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 1205910004351 Membrane transport protein; Region: Mem_trans; cl09117 1205910004352 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1205910004353 E3 interaction surface; other site 1205910004354 lipoyl attachment site [posttranslational modification]; other site 1205910004355 e3 binding domain; Region: E3_binding; pfam02817 1205910004356 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 1205910004357 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1205910004358 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1205910004359 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1205910004360 alpha subunit interface [polypeptide binding]; other site 1205910004361 TPP binding site [chemical binding]; other site 1205910004362 heterodimer interface [polypeptide binding]; other site 1205910004363 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1205910004364 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1205910004365 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1205910004366 TPP-binding site [chemical binding]; other site 1205910004367 tetramer interface [polypeptide binding]; other site 1205910004368 heterodimer interface [polypeptide binding]; other site 1205910004369 phosphorylation loop region [posttranslational modification] 1205910004370 Predicted ATPase [General function prediction only]; Region: COG5293 1205910004371 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 1205910004372 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1205910004373 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1205910004374 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1205910004375 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205910004376 dimerization interface [polypeptide binding]; other site 1205910004377 putative DNA binding site [nucleotide binding]; other site 1205910004378 putative Zn2+ binding site [ion binding]; other site 1205910004379 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205910004380 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1205910004381 CAAX protease self-immunity; Region: Abi; pfam02517 1205910004382 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205910004383 RNA polymerase factor sigma-70; Validated; Region: PRK09047 1205910004384 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205910004385 DNA binding residues [nucleotide binding] 1205910004386 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1205910004387 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1205910004388 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1205910004389 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1205910004390 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1205910004391 putative active site [active] 1205910004392 catalytic triad [active] 1205910004393 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1205910004394 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1205910004395 dimerization interface [polypeptide binding]; other site 1205910004396 ATP binding site [chemical binding]; other site 1205910004397 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1205910004398 dimerization interface [polypeptide binding]; other site 1205910004399 ATP binding site [chemical binding]; other site 1205910004400 PQQ-like domain; Region: PQQ_2; pfam13360 1205910004401 PQQ-like domain; Region: PQQ_2; pfam13360 1205910004402 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1205910004403 PQQ-like domain; Region: PQQ_2; pfam13360 1205910004404 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910004405 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1205910004406 non-specific DNA binding site [nucleotide binding]; other site 1205910004407 salt bridge; other site 1205910004408 sequence-specific DNA binding site [nucleotide binding]; other site 1205910004409 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1205910004410 putative catalytic site [active] 1205910004411 putative metal binding site [ion binding]; other site 1205910004412 putative phosphate binding site [ion binding]; other site 1205910004413 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1205910004414 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1205910004415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910004416 dimer interface [polypeptide binding]; other site 1205910004417 conserved gate region; other site 1205910004418 putative PBP binding loops; other site 1205910004419 ABC-ATPase subunit interface; other site 1205910004420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910004421 dimer interface [polypeptide binding]; other site 1205910004422 conserved gate region; other site 1205910004423 ABC-ATPase subunit interface; other site 1205910004424 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1205910004425 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1205910004426 Walker A/P-loop; other site 1205910004427 ATP binding site [chemical binding]; other site 1205910004428 Q-loop/lid; other site 1205910004429 ABC transporter signature motif; other site 1205910004430 Walker B; other site 1205910004431 D-loop; other site 1205910004432 H-loop/switch region; other site 1205910004433 choline dehydrogenase; Validated; Region: PRK02106 1205910004434 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1205910004435 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1205910004436 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 1205910004437 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 1205910004438 tetramerization interface [polypeptide binding]; other site 1205910004439 NAD(P) binding site [chemical binding]; other site 1205910004440 catalytic residues [active] 1205910004441 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1205910004442 intersubunit interface [polypeptide binding]; other site 1205910004443 active site 1205910004444 Zn2+ binding site [ion binding]; other site 1205910004445 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1205910004446 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910004447 non-specific DNA binding site [nucleotide binding]; other site 1205910004448 salt bridge; other site 1205910004449 sequence-specific DNA binding site [nucleotide binding]; other site 1205910004450 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1205910004451 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1205910004452 Walker A/P-loop; other site 1205910004453 ATP binding site [chemical binding]; other site 1205910004454 Q-loop/lid; other site 1205910004455 ABC transporter signature motif; other site 1205910004456 Walker B; other site 1205910004457 D-loop; other site 1205910004458 H-loop/switch region; other site 1205910004459 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1205910004460 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205910004461 active site 1205910004462 metal binding site [ion binding]; metal-binding site 1205910004463 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1205910004464 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1205910004465 DinB superfamily; Region: DinB_2; pfam12867 1205910004466 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 1205910004467 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cl01321 1205910004468 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1205910004469 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1205910004470 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1205910004471 DXD motif; other site 1205910004472 WbqC-like protein family; Region: WbqC; pfam08889 1205910004473 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1205910004474 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1205910004475 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205910004476 NAD(P) binding site [chemical binding]; other site 1205910004477 active site 1205910004478 Domain of unknown function (DUF202); Region: DUF202; cl09954 1205910004479 Domain of unknown function (DUF202); Region: DUF202; cl09954 1205910004480 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1205910004481 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1205910004482 catalytic residues [active] 1205910004483 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1205910004484 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1205910004485 Walker A/P-loop; other site 1205910004486 ATP binding site [chemical binding]; other site 1205910004487 Q-loop/lid; other site 1205910004488 ABC transporter signature motif; other site 1205910004489 Walker B; other site 1205910004490 D-loop; other site 1205910004491 H-loop/switch region; other site 1205910004492 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205910004493 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910004494 active site 1205910004495 phosphorylation site [posttranslational modification] 1205910004496 intermolecular recognition site; other site 1205910004497 dimerization interface [polypeptide binding]; other site 1205910004498 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205910004499 DNA binding site [nucleotide binding] 1205910004500 PBP superfamily domain; Region: PBP_like_2; cl17296 1205910004501 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1205910004502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910004503 dimer interface [polypeptide binding]; other site 1205910004504 conserved gate region; other site 1205910004505 putative PBP binding loops; other site 1205910004506 ABC-ATPase subunit interface; other site 1205910004507 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1205910004508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910004509 dimer interface [polypeptide binding]; other site 1205910004510 conserved gate region; other site 1205910004511 putative PBP binding loops; other site 1205910004512 ABC-ATPase subunit interface; other site 1205910004513 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 1205910004514 Ca2+ binding site [ion binding]; other site 1205910004515 EF-hand domain pair; Region: EF_hand_6; pfam13833 1205910004516 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1205910004517 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1205910004518 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1205910004519 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1205910004520 HisG, C-terminal domain; Region: HisG_C; pfam08029 1205910004521 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1205910004522 homodimer interface [polypeptide binding]; other site 1205910004523 putative metal binding site [ion binding]; other site 1205910004524 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1205910004525 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205910004526 NAD(P) binding site [chemical binding]; other site 1205910004527 active site 1205910004528 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910004529 S-adenosylmethionine binding site [chemical binding]; other site 1205910004530 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1205910004531 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1205910004532 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1205910004533 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1205910004534 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1205910004535 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1205910004536 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1205910004537 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205910004538 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1205910004539 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1205910004540 active site 1205910004541 SUMO-1 interface [polypeptide binding]; other site 1205910004542 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910004543 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1205910004544 classical (c) SDRs; Region: SDR_c; cd05233 1205910004545 NAD(P) binding site [chemical binding]; other site 1205910004546 active site 1205910004547 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1205910004548 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1205910004549 ligand binding site [chemical binding]; other site 1205910004550 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1205910004551 Fasciclin domain; Region: Fasciclin; pfam02469 1205910004552 H+ Antiporter protein; Region: 2A0121; TIGR00900 1205910004553 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910004554 putative substrate translocation pore; other site 1205910004555 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1205910004556 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1205910004557 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1205910004558 AsnC family; Region: AsnC_trans_reg; pfam01037 1205910004559 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1205910004560 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1205910004561 active site 1205910004562 acyl-CoA synthetase; Validated; Region: PRK08162 1205910004563 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 1205910004564 acyl-activating enzyme (AAE) consensus motif; other site 1205910004565 putative active site [active] 1205910004566 AMP binding site [chemical binding]; other site 1205910004567 putative CoA binding site [chemical binding]; other site 1205910004568 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1205910004569 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205910004570 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1205910004571 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205910004572 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1205910004573 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1205910004574 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205910004575 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1205910004576 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1205910004577 substrate binding site [chemical binding]; other site 1205910004578 ATP binding site [chemical binding]; other site 1205910004579 Archaeal ATPase; Region: Arch_ATPase; pfam01637 1205910004580 Restriction endonuclease; Region: Mrr_cat; pfam04471 1205910004581 Smr domain; Region: Smr; pfam01713 1205910004582 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1205910004583 Leucine-rich repeats; other site 1205910004584 Substrate binding site [chemical binding]; other site 1205910004585 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 1205910004586 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910004587 short chain dehydrogenase; Provisional; Region: PRK06197 1205910004588 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205910004589 NAD(P) binding site [chemical binding]; other site 1205910004590 active site 1205910004591 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1205910004592 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205910004593 Coenzyme A binding pocket [chemical binding]; other site 1205910004594 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 1205910004595 TIGR02452 family protein; Region: TIGR02452 1205910004596 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910004597 S-adenosylmethionine binding site [chemical binding]; other site 1205910004598 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1205910004599 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1205910004600 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1205910004601 putative active site [active] 1205910004602 putative metal binding site [ion binding]; other site 1205910004603 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205910004604 DNA-binding site [nucleotide binding]; DNA binding site 1205910004605 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910004606 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910004607 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1205910004608 Predicted membrane protein [Function unknown]; Region: COG2311 1205910004609 Protein of unknown function (DUF418); Region: DUF418; cl12135 1205910004610 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1205910004611 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1205910004612 adenosine deaminase; Provisional; Region: PRK09358 1205910004613 active site 1205910004614 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1205910004615 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1205910004616 dimer interface [polypeptide binding]; other site 1205910004617 NADP binding site [chemical binding]; other site 1205910004618 catalytic residues [active] 1205910004619 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910004620 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910004621 HD domain; Region: HD_3; pfam13023 1205910004622 hypothetical protein; Provisional; Region: PRK10621 1205910004623 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1205910004624 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1205910004625 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1205910004626 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1205910004627 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910004628 Walker A/P-loop; other site 1205910004629 ATP binding site [chemical binding]; other site 1205910004630 Q-loop/lid; other site 1205910004631 ABC transporter signature motif; other site 1205910004632 Walker B; other site 1205910004633 D-loop; other site 1205910004634 H-loop/switch region; other site 1205910004635 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1205910004636 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1205910004637 ACT domain; Region: ACT_6; pfam13740 1205910004638 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1205910004639 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1205910004640 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1205910004641 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205910004642 motif II; other site 1205910004643 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1205910004644 catalytic core [active] 1205910004645 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 1205910004646 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 1205910004647 Domain of unknown function (DUF309); Region: DUF309; pfam03745 1205910004648 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205910004649 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1205910004650 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205910004651 acyl-activating enzyme (AAE) consensus motif; other site 1205910004652 AMP binding site [chemical binding]; other site 1205910004653 active site 1205910004654 CoA binding site [chemical binding]; other site 1205910004655 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205910004656 Fic family protein [Function unknown]; Region: COG3177 1205910004657 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1205910004658 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 1205910004659 Type II/IV secretion system protein; Region: T2SE; pfam00437 1205910004660 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1205910004661 ATP binding site [chemical binding]; other site 1205910004662 Walker A motif; other site 1205910004663 hexamer interface [polypeptide binding]; other site 1205910004664 Walker B motif; other site 1205910004665 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1205910004666 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1205910004667 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205910004668 ATP binding site [chemical binding]; other site 1205910004669 putative Mg++ binding site [ion binding]; other site 1205910004670 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205910004671 nucleotide binding region [chemical binding]; other site 1205910004672 ATP-binding site [chemical binding]; other site 1205910004673 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1205910004674 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1205910004675 anti sigma factor interaction site; other site 1205910004676 regulatory phosphorylation site [posttranslational modification]; other site 1205910004677 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1205910004678 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1205910004679 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1205910004680 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1205910004681 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1205910004682 putative active site [active] 1205910004683 putative CoA binding site [chemical binding]; other site 1205910004684 nudix motif; other site 1205910004685 metal binding site [ion binding]; metal-binding site 1205910004686 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1205910004687 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1205910004688 minor groove reading motif; other site 1205910004689 helix-hairpin-helix signature motif; other site 1205910004690 substrate binding pocket [chemical binding]; other site 1205910004691 active site 1205910004692 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1205910004693 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1205910004694 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1205910004695 ligand binding site [chemical binding]; other site 1205910004696 flexible hinge region; other site 1205910004697 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1205910004698 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1205910004699 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1205910004700 nudix motif; other site 1205910004701 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1205910004702 homotrimer interaction site [polypeptide binding]; other site 1205910004703 putative active site [active] 1205910004704 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1205910004705 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1205910004706 DTAP/Switch II; other site 1205910004707 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1205910004708 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1205910004709 DTAP/Switch II; other site 1205910004710 Switch I; other site 1205910004711 Transglycosylase; Region: Transgly; pfam00912 1205910004712 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1205910004713 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1205910004714 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1205910004715 Yqey-like protein; Region: YqeY; pfam09424 1205910004716 phosphodiesterase YaeI; Provisional; Region: PRK11340 1205910004717 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1205910004718 putative active site [active] 1205910004719 putative metal binding site [ion binding]; other site 1205910004720 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1205910004721 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1205910004722 active site 1205910004723 catalytic tetrad [active] 1205910004724 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 1205910004725 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910004726 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910004727 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910004728 putative substrate translocation pore; other site 1205910004729 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1205910004730 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 1205910004731 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1205910004732 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1205910004733 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1205910004734 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1205910004735 NB-ARC domain; Region: NB-ARC; pfam00931 1205910004736 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1205910004737 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1205910004738 binding surface 1205910004739 TPR motif; other site 1205910004740 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1205910004741 binding surface 1205910004742 TPR motif; other site 1205910004743 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1205910004744 TPR motif; other site 1205910004745 binding surface 1205910004746 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1205910004747 nudix motif; other site 1205910004748 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 1205910004749 Uncharacterized protein conserved in archaea (DUF2115); Region: DUF2115; cl01681 1205910004750 DNA polymerase III subunit beta; Validated; Region: PRK07761 1205910004751 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1205910004752 putative DNA binding surface [nucleotide binding]; other site 1205910004753 dimer interface [polypeptide binding]; other site 1205910004754 beta-clamp/clamp loader binding surface; other site 1205910004755 beta-clamp/translesion DNA polymerase binding surface; other site 1205910004756 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1205910004757 CoenzymeA binding site [chemical binding]; other site 1205910004758 subunit interaction site [polypeptide binding]; other site 1205910004759 PHB binding site; other site 1205910004760 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205910004761 Ligand Binding Site [chemical binding]; other site 1205910004762 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205910004763 Ligand Binding Site [chemical binding]; other site 1205910004764 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205910004765 Ligand Binding Site [chemical binding]; other site 1205910004766 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205910004767 Ligand Binding Site [chemical binding]; other site 1205910004768 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1205910004769 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1205910004770 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1205910004771 NAD(P) binding site [chemical binding]; other site 1205910004772 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 1205910004773 seryl-tRNA synthetase; Provisional; Region: PRK05431 1205910004774 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1205910004775 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1205910004776 dimer interface [polypeptide binding]; other site 1205910004777 active site 1205910004778 motif 1; other site 1205910004779 motif 2; other site 1205910004780 motif 3; other site 1205910004781 prephenate dehydratase; Provisional; Region: PRK11898 1205910004782 Prephenate dehydratase; Region: PDT; pfam00800 1205910004783 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1205910004784 putative L-Phe binding site [chemical binding]; other site 1205910004785 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1205910004786 active site 1205910004787 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1205910004788 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1205910004789 Mg2+ binding site [ion binding]; other site 1205910004790 PAS fold; Region: PAS; pfam00989 1205910004791 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1205910004792 putative active site [active] 1205910004793 heme pocket [chemical binding]; other site 1205910004794 GAF domain; Region: GAF; pfam01590 1205910004795 PAS domain S-box; Region: sensory_box; TIGR00229 1205910004796 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1205910004797 putative active site [active] 1205910004798 heme pocket [chemical binding]; other site 1205910004799 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1205910004800 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1205910004801 dimer interface [polypeptide binding]; other site 1205910004802 phosphorylation site [posttranslational modification] 1205910004803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910004804 ATP binding site [chemical binding]; other site 1205910004805 Mg2+ binding site [ion binding]; other site 1205910004806 G-X-G motif; other site 1205910004807 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1205910004808 active site residue [active] 1205910004809 Subtilisin inhibitor-like; Region: SSI; cl11594 1205910004810 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1205910004811 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1205910004812 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1205910004813 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1205910004814 phosphopeptide binding site; other site 1205910004815 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1205910004816 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1205910004817 phosphopeptide binding site; other site 1205910004818 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1205910004819 Protein phosphatase 2C; Region: PP2C; pfam00481 1205910004820 active site 1205910004821 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1205910004822 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1205910004823 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1205910004824 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205910004825 active site 1205910004826 ATP binding site [chemical binding]; other site 1205910004827 substrate binding site [chemical binding]; other site 1205910004828 activation loop (A-loop); other site 1205910004829 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1205910004830 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205910004831 active site 1205910004832 ATP binding site [chemical binding]; other site 1205910004833 substrate binding site [chemical binding]; other site 1205910004834 activation loop (A-loop); other site 1205910004835 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1205910004836 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1205910004837 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1205910004838 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1205910004839 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 1205910004840 Rhomboid family; Region: Rhomboid; pfam01694 1205910004841 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1205910004842 active site 1205910004843 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1205910004844 Tic20-like protein; Region: Tic20; pfam09685 1205910004845 Transcription factor WhiB; Region: Whib; pfam02467 1205910004846 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1205910004847 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1205910004848 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 1205910004849 putative dimerization interface [polypeptide binding]; other site 1205910004850 EamA-like transporter family; Region: EamA; pfam00892 1205910004851 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910004852 sequence-specific DNA binding site [nucleotide binding]; other site 1205910004853 salt bridge; other site 1205910004854 acyl-CoA synthetase; Validated; Region: PRK07788 1205910004855 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205910004856 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205910004857 acyl-activating enzyme (AAE) consensus motif; other site 1205910004858 AMP binding site [chemical binding]; other site 1205910004859 active site 1205910004860 CoA binding site [chemical binding]; other site 1205910004861 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1205910004862 MarR family; Region: MarR; pfam01047 1205910004863 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 1205910004864 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1205910004865 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205910004866 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 1205910004867 NAD(P) binding site [chemical binding]; other site 1205910004868 active site 1205910004869 GAF domain; Region: GAF_2; pfam13185 1205910004870 GAF domain; Region: GAF; pfam01590 1205910004871 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1205910004872 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1205910004873 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1205910004874 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205910004875 NAD(P) binding site [chemical binding]; other site 1205910004876 active site 1205910004877 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205910004878 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1205910004879 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1205910004880 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1205910004881 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1205910004882 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1205910004883 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1205910004884 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1205910004885 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1205910004886 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 1205910004887 putative deacylase active site [active] 1205910004888 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 1205910004889 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 1205910004890 substrate binding site [chemical binding]; other site 1205910004891 dimer interface [polypeptide binding]; other site 1205910004892 NADP binding site [chemical binding]; other site 1205910004893 catalytic residues [active] 1205910004894 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1205910004895 active site 2 [active] 1205910004896 active site 1 [active] 1205910004897 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1205910004898 hydrophobic ligand binding site; other site 1205910004899 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1205910004900 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1205910004901 E3 interaction surface; other site 1205910004902 lipoyl attachment site [posttranslational modification]; other site 1205910004903 e3 binding domain; Region: E3_binding; pfam02817 1205910004904 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1205910004905 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1205910004906 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1205910004907 alpha subunit interface [polypeptide binding]; other site 1205910004908 TPP binding site [chemical binding]; other site 1205910004909 heterodimer interface [polypeptide binding]; other site 1205910004910 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1205910004911 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1205910004912 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1205910004913 tetramer interface [polypeptide binding]; other site 1205910004914 TPP-binding site [chemical binding]; other site 1205910004915 heterodimer interface [polypeptide binding]; other site 1205910004916 phosphorylation loop region [posttranslational modification] 1205910004917 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1205910004918 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1205910004919 Walker A/P-loop; other site 1205910004920 ATP binding site [chemical binding]; other site 1205910004921 Q-loop/lid; other site 1205910004922 ABC transporter signature motif; other site 1205910004923 Walker B; other site 1205910004924 D-loop; other site 1205910004925 H-loop/switch region; other site 1205910004926 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205910004927 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205910004928 DNA binding residues [nucleotide binding] 1205910004929 dimerization interface [polypeptide binding]; other site 1205910004930 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1205910004931 Lipase (class 2); Region: Lipase_2; pfam01674 1205910004932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910004933 metabolite-proton symporter; Region: 2A0106; TIGR00883 1205910004934 putative substrate translocation pore; other site 1205910004935 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 1205910004936 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205910004937 NAD(P) binding site [chemical binding]; other site 1205910004938 active site 1205910004939 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1205910004940 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1205910004941 active site 1205910004942 non-prolyl cis peptide bond; other site 1205910004943 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1205910004944 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1205910004945 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910004946 AAA domain; Region: AAA_21; pfam13304 1205910004947 Walker A/P-loop; other site 1205910004948 ATP binding site [chemical binding]; other site 1205910004949 Q-loop/lid; other site 1205910004950 ABC transporter signature motif; other site 1205910004951 Walker B; other site 1205910004952 D-loop; other site 1205910004953 H-loop/switch region; other site 1205910004954 CAAX protease self-immunity; Region: Abi; pfam02517 1205910004955 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910004956 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1205910004957 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1205910004958 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1205910004959 potential catalytic triad [active] 1205910004960 conserved cys residue [active] 1205910004961 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910004962 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910004963 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1205910004964 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1205910004965 TAP-like protein; Region: Abhydrolase_4; pfam08386 1205910004966 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1205910004967 DNA gyrase subunit A; Validated; Region: PRK05560 1205910004968 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1205910004969 CAP-like domain; other site 1205910004970 active site 1205910004971 primary dimer interface [polypeptide binding]; other site 1205910004972 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1205910004973 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1205910004974 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1205910004975 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1205910004976 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1205910004977 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1205910004978 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1205910004979 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910004980 ATP binding site [chemical binding]; other site 1205910004981 Mg2+ binding site [ion binding]; other site 1205910004982 G-X-G motif; other site 1205910004983 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1205910004984 anchoring element; other site 1205910004985 dimer interface [polypeptide binding]; other site 1205910004986 ATP binding site [chemical binding]; other site 1205910004987 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1205910004988 active site 1205910004989 putative metal-binding site [ion binding]; other site 1205910004990 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1205910004991 Protein of unknown function (DUF721); Region: DUF721; pfam05258 1205910004992 recombination protein F; Reviewed; Region: recF; PRK00064 1205910004993 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1205910004994 Walker A/P-loop; other site 1205910004995 ATP binding site [chemical binding]; other site 1205910004996 Q-loop/lid; other site 1205910004997 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910004998 ABC transporter signature motif; other site 1205910004999 Walker B; other site 1205910005000 D-loop; other site 1205910005001 H-loop/switch region; other site 1205910005002 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1205910005003 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 1205910005004 DNA polymerase III subunit beta; Validated; Region: PRK07761 1205910005005 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1205910005006 putative DNA binding surface [nucleotide binding]; other site 1205910005007 dimer interface [polypeptide binding]; other site 1205910005008 beta-clamp/clamp loader binding surface; other site 1205910005009 beta-clamp/translesion DNA polymerase binding surface; other site 1205910005010 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 1205910005011 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205910005012 Walker A motif; other site 1205910005013 ATP binding site [chemical binding]; other site 1205910005014 Walker B motif; other site 1205910005015 arginine finger; other site 1205910005016 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1205910005017 DnaA box-binding interface [nucleotide binding]; other site 1205910005018 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 1205910005019 Ribonuclease P; Region: Ribonuclease_P; pfam00825 1205910005020 Haemolytic domain; Region: Haemolytic; pfam01809 1205910005021 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1205910005022 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1205910005023 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1205910005024 G-X-X-G motif; other site 1205910005025 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1205910005026 RxxxH motif; other site 1205910005027 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1205910005028 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1205910005029 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1205910005030 P-loop; other site 1205910005031 Magnesium ion binding site [ion binding]; other site 1205910005032 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1205910005033 Magnesium ion binding site [ion binding]; other site 1205910005034 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1205910005035 ParB-like nuclease domain; Region: ParBc; pfam02195 1205910005036 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1205910005037 catalytic residues [active] 1205910005038 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1205910005039 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205910005040 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1205910005041 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910005042 ATP binding site [chemical binding]; other site 1205910005043 Mg2+ binding site [ion binding]; other site 1205910005044 G-X-G motif; other site 1205910005045 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205910005046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910005047 active site 1205910005048 phosphorylation site [posttranslational modification] 1205910005049 intermolecular recognition site; other site 1205910005050 dimerization interface [polypeptide binding]; other site 1205910005051 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205910005052 DNA binding residues [nucleotide binding] 1205910005053 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 1205910005054 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205910005055 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205910005056 DNA binding residues [nucleotide binding] 1205910005057 integral membrane protein MviN; Region: mviN; TIGR01695 1205910005058 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1205910005059 integral membrane protein MviN; Region: mviN; TIGR01695 1205910005060 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1205910005061 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1205910005062 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1205910005063 active site 1205910005064 NTP binding site [chemical binding]; other site 1205910005065 metal binding triad [ion binding]; metal-binding site 1205910005066 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1205910005067 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1205910005068 Zn2+ binding site [ion binding]; other site 1205910005069 Mg2+ binding site [ion binding]; other site 1205910005070 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910005071 S-adenosylmethionine binding site [chemical binding]; other site 1205910005072 H+ Antiporter protein; Region: 2A0121; TIGR00900 1205910005073 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1205910005074 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1205910005075 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1205910005076 Transglycosylase; Region: Transgly; pfam00912 1205910005077 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1205910005078 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1205910005079 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1205910005080 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1205910005081 dimer interface [polypeptide binding]; other site 1205910005082 ssDNA binding site [nucleotide binding]; other site 1205910005083 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1205910005084 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1205910005085 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1205910005086 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1205910005087 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1205910005088 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1205910005089 amidase catalytic site [active] 1205910005090 Zn binding residues [ion binding]; other site 1205910005091 substrate binding site [chemical binding]; other site 1205910005092 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1205910005093 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1205910005094 replicative DNA helicase; Region: DnaB; TIGR00665 1205910005095 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1205910005096 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1205910005097 Walker A motif; other site 1205910005098 ATP binding site [chemical binding]; other site 1205910005099 Walker B motif; other site 1205910005100 DNA binding loops [nucleotide binding] 1205910005101 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1205910005102 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1205910005103 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1205910005104 NAD(P) binding site [chemical binding]; other site 1205910005105 substrate binding site [chemical binding]; other site 1205910005106 dimer interface [polypeptide binding]; other site 1205910005107 Bacterial PH domain; Region: DUF304; pfam03703 1205910005108 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1205910005109 active site 1205910005110 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1205910005111 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1205910005112 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1205910005113 nucleoside/Zn binding site; other site 1205910005114 dimer interface [polypeptide binding]; other site 1205910005115 catalytic motif [active] 1205910005116 Predicted transcriptional regulators [Transcription]; Region: COG1695 1205910005117 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1205910005118 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1205910005119 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1205910005120 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1205910005121 active site 1205910005122 FMN binding site [chemical binding]; other site 1205910005123 2,4-decadienoyl-CoA binding site; other site 1205910005124 catalytic residue [active] 1205910005125 4Fe-4S cluster binding site [ion binding]; other site 1205910005126 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1205910005127 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205910005128 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1205910005129 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910005130 non-specific DNA binding site [nucleotide binding]; other site 1205910005131 salt bridge; other site 1205910005132 sequence-specific DNA binding site [nucleotide binding]; other site 1205910005133 pyruvate dehydrogenase; Provisional; Region: PRK06546 1205910005134 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1205910005135 PYR/PP interface [polypeptide binding]; other site 1205910005136 tetramer interface [polypeptide binding]; other site 1205910005137 dimer interface [polypeptide binding]; other site 1205910005138 TPP binding site [chemical binding]; other site 1205910005139 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1205910005140 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1205910005141 TPP-binding site [chemical binding]; other site 1205910005142 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1205910005143 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205910005144 Walker A motif; other site 1205910005145 ATP binding site [chemical binding]; other site 1205910005146 Walker B motif; other site 1205910005147 arginine finger; other site 1205910005148 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1205910005149 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 1205910005150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910005151 S-adenosylmethionine binding site [chemical binding]; other site 1205910005152 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1205910005153 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1205910005154 FMN binding site [chemical binding]; other site 1205910005155 active site 1205910005156 substrate binding site [chemical binding]; other site 1205910005157 catalytic residue [active] 1205910005158 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1205910005159 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 1205910005160 DNA binding residues [nucleotide binding] 1205910005161 putative dimer interface [polypeptide binding]; other site 1205910005162 hypothetical protein; Validated; Region: PRK00153 1205910005163 recombination protein RecR; Reviewed; Region: recR; PRK00076 1205910005164 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1205910005165 RecR protein; Region: RecR; pfam02132 1205910005166 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1205910005167 putative active site [active] 1205910005168 putative metal-binding site [ion binding]; other site 1205910005169 tetramer interface [polypeptide binding]; other site 1205910005170 aspartate kinase; Reviewed; Region: PRK06635 1205910005171 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1205910005172 putative nucleotide binding site [chemical binding]; other site 1205910005173 putative catalytic residues [active] 1205910005174 putative Mg ion binding site [ion binding]; other site 1205910005175 putative aspartate binding site [chemical binding]; other site 1205910005176 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1205910005177 putative allosteric regulatory site; other site 1205910005178 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1205910005179 putative allosteric regulatory residue; other site 1205910005180 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1205910005181 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1205910005182 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1205910005183 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205910005184 DNA-binding site [nucleotide binding]; DNA binding site 1205910005185 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1205910005186 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1205910005187 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1205910005188 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1205910005189 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910005190 non-specific DNA binding site [nucleotide binding]; other site 1205910005191 salt bridge; other site 1205910005192 sequence-specific DNA binding site [nucleotide binding]; other site 1205910005193 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1205910005194 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1205910005195 Protein of unknown function (DUF952); Region: DUF952; pfam06108 1205910005196 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1205910005197 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1205910005198 FkbH-like domain; Region: FkbH; TIGR01686 1205910005199 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205910005200 active site 1205910005201 motif I; other site 1205910005202 motif II; other site 1205910005203 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1205910005204 acyl carrier protein; Provisional; Region: PRK07081 1205910005205 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205910005206 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205910005207 active site 1205910005208 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1205910005209 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205910005210 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205910005211 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1205910005212 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205910005213 active site 1205910005214 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1205910005215 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205910005216 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205910005217 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1205910005218 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 1205910005219 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205910005220 catalytic residue [active] 1205910005221 Condensation domain; Region: Condensation; pfam00668 1205910005222 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1205910005223 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1205910005224 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205910005225 acyl-activating enzyme (AAE) consensus motif; other site 1205910005226 AMP binding site [chemical binding]; other site 1205910005227 active site 1205910005228 CoA binding site [chemical binding]; other site 1205910005229 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205910005230 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1205910005231 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1205910005232 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205910005233 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1205910005234 active site 1205910005235 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1205910005236 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1205910005237 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1205910005238 putative NADP binding site [chemical binding]; other site 1205910005239 active site 1205910005240 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205910005241 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205910005242 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1205910005243 active site 1205910005244 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1205910005245 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1205910005246 putative NADP binding site [chemical binding]; other site 1205910005247 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1205910005248 active site 1205910005249 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205910005250 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205910005251 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1205910005252 active site 1205910005253 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205910005254 Condensation domain; Region: Condensation; pfam00668 1205910005255 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1205910005256 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1205910005257 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1205910005258 acyl-activating enzyme (AAE) consensus motif; other site 1205910005259 AMP binding site [chemical binding]; other site 1205910005260 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205910005261 Condensation domain; Region: Condensation; pfam00668 1205910005262 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1205910005263 Condensation domain; Region: Condensation; pfam00668 1205910005264 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1205910005265 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1205910005266 acyl-activating enzyme (AAE) consensus motif; other site 1205910005267 AMP binding site [chemical binding]; other site 1205910005268 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205910005269 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205910005270 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1205910005271 active site 1205910005272 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1205910005273 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205910005274 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205910005275 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1205910005276 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910005277 S-adenosylmethionine binding site [chemical binding]; other site 1205910005278 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1205910005279 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910005280 Walker A/P-loop; other site 1205910005281 ATP binding site [chemical binding]; other site 1205910005282 Q-loop/lid; other site 1205910005283 ABC transporter signature motif; other site 1205910005284 Walker B; other site 1205910005285 D-loop; other site 1205910005286 H-loop/switch region; other site 1205910005287 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1205910005288 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1205910005289 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 1205910005290 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1205910005291 NAD(P) binding site [chemical binding]; other site 1205910005292 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910005293 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1205910005294 sequence-specific DNA binding site [nucleotide binding]; other site 1205910005295 salt bridge; other site 1205910005296 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1205910005297 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1205910005298 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1205910005299 E3 interaction surface; other site 1205910005300 lipoyl attachment site [posttranslational modification]; other site 1205910005301 e3 binding domain; Region: E3_binding; pfam02817 1205910005302 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1205910005303 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1205910005304 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1205910005305 alpha subunit interface [polypeptide binding]; other site 1205910005306 TPP binding site [chemical binding]; other site 1205910005307 heterodimer interface [polypeptide binding]; other site 1205910005308 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1205910005309 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1205910005310 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1205910005311 tetramer interface [polypeptide binding]; other site 1205910005312 TPP-binding site [chemical binding]; other site 1205910005313 heterodimer interface [polypeptide binding]; other site 1205910005314 phosphorylation loop region [posttranslational modification] 1205910005315 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1205910005316 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205910005317 DNA-binding site [nucleotide binding]; DNA binding site 1205910005318 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1205910005319 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1205910005320 active site 1205910005321 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1205910005322 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1205910005323 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205910005324 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205910005325 motif II; other site 1205910005326 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 1205910005327 putative metal binding residues [ion binding]; other site 1205910005328 signature motif; other site 1205910005329 dimer interface [polypeptide binding]; other site 1205910005330 active site 1205910005331 polyP binding site; other site 1205910005332 substrate binding site [chemical binding]; other site 1205910005333 acceptor-phosphate pocket; other site 1205910005334 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205910005335 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910005336 active site 1205910005337 phosphorylation site [posttranslational modification] 1205910005338 intermolecular recognition site; other site 1205910005339 dimerization interface [polypeptide binding]; other site 1205910005340 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205910005341 DNA binding site [nucleotide binding] 1205910005342 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1205910005343 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1205910005344 dimerization interface [polypeptide binding]; other site 1205910005345 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1205910005346 dimer interface [polypeptide binding]; other site 1205910005347 phosphorylation site [posttranslational modification] 1205910005348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910005349 ATP binding site [chemical binding]; other site 1205910005350 Mg2+ binding site [ion binding]; other site 1205910005351 G-X-G motif; other site 1205910005352 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1205910005353 putative active site [active] 1205910005354 homotetrameric interface [polypeptide binding]; other site 1205910005355 metal binding site [ion binding]; metal-binding site 1205910005356 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 1205910005357 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205910005358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910005359 active site 1205910005360 phosphorylation site [posttranslational modification] 1205910005361 intermolecular recognition site; other site 1205910005362 dimerization interface [polypeptide binding]; other site 1205910005363 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205910005364 DNA binding residues [nucleotide binding] 1205910005365 dimerization interface [polypeptide binding]; other site 1205910005366 putative amidase; Provisional; Region: PRK06169 1205910005367 Amidase; Region: Amidase; pfam01425 1205910005368 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1205910005369 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 1205910005370 NAD binding site [chemical binding]; other site 1205910005371 ligand binding site [chemical binding]; other site 1205910005372 catalytic site [active] 1205910005373 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 1205910005374 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1205910005375 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1205910005376 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1205910005377 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205910005378 DNA-binding site [nucleotide binding]; DNA binding site 1205910005379 FCD domain; Region: FCD; pfam07729 1205910005380 succinic semialdehyde dehydrogenase; Region: PLN02278 1205910005381 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1205910005382 tetramerization interface [polypeptide binding]; other site 1205910005383 NAD(P) binding site [chemical binding]; other site 1205910005384 catalytic residues [active] 1205910005385 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 1205910005386 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1205910005387 inhibitor-cofactor binding pocket; inhibition site 1205910005388 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910005389 catalytic residue [active] 1205910005390 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1205910005391 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1205910005392 alpha-gamma subunit interface [polypeptide binding]; other site 1205910005393 beta-gamma subunit interface [polypeptide binding]; other site 1205910005394 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1205910005395 gamma-beta subunit interface [polypeptide binding]; other site 1205910005396 alpha-beta subunit interface [polypeptide binding]; other site 1205910005397 urease subunit alpha; Reviewed; Region: ureC; PRK13206 1205910005398 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1205910005399 subunit interactions [polypeptide binding]; other site 1205910005400 active site 1205910005401 flap region; other site 1205910005402 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1205910005403 UreF; Region: UreF; pfam01730 1205910005404 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1205910005405 UreD urease accessory protein; Region: UreD; cl00530 1205910005406 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 1205910005407 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1205910005408 Walker A/P-loop; other site 1205910005409 ATP binding site [chemical binding]; other site 1205910005410 Q-loop/lid; other site 1205910005411 ABC transporter signature motif; other site 1205910005412 Walker B; other site 1205910005413 D-loop; other site 1205910005414 H-loop/switch region; other site 1205910005415 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1205910005416 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910005417 dimer interface [polypeptide binding]; other site 1205910005418 conserved gate region; other site 1205910005419 putative PBP binding loops; other site 1205910005420 ABC-ATPase subunit interface; other site 1205910005421 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1205910005422 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1205910005423 Walker A/P-loop; other site 1205910005424 ATP binding site [chemical binding]; other site 1205910005425 Q-loop/lid; other site 1205910005426 ABC transporter signature motif; other site 1205910005427 Walker B; other site 1205910005428 D-loop; other site 1205910005429 H-loop/switch region; other site 1205910005430 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1205910005431 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1205910005432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1205910005433 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1205910005434 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 1205910005435 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205910005436 dimerization interface [polypeptide binding]; other site 1205910005437 putative DNA binding site [nucleotide binding]; other site 1205910005438 putative Zn2+ binding site [ion binding]; other site 1205910005439 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1205910005440 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1205910005441 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1205910005442 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1205910005443 Walker A/P-loop; other site 1205910005444 ATP binding site [chemical binding]; other site 1205910005445 Q-loop/lid; other site 1205910005446 ABC transporter signature motif; other site 1205910005447 Walker B; other site 1205910005448 D-loop; other site 1205910005449 H-loop/switch region; other site 1205910005450 Predicted transcriptional regulators [Transcription]; Region: COG1695 1205910005451 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1205910005452 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1205910005453 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1205910005454 Protein of unknown function (DUF418); Region: DUF418; cl12135 1205910005455 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1205910005456 Dak1 domain; Region: Dak1; pfam02733 1205910005457 DAK2 domain; Region: Dak2; cl03685 1205910005458 classical (c) SDRs; Region: SDR_c; cd05233 1205910005459 NAD(P) binding site [chemical binding]; other site 1205910005460 active site 1205910005461 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1205910005462 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1205910005463 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 1205910005464 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910005465 Walker A/P-loop; other site 1205910005466 ATP binding site [chemical binding]; other site 1205910005467 Q-loop/lid; other site 1205910005468 ABC transporter signature motif; other site 1205910005469 Walker B; other site 1205910005470 D-loop; other site 1205910005471 H-loop/switch region; other site 1205910005472 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1205910005473 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1205910005474 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1205910005475 GAF domain; Region: GAF_3; pfam13492 1205910005476 Histidine kinase; Region: HisKA_3; pfam07730 1205910005477 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1205910005478 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1205910005479 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1205910005480 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1205910005481 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1205910005482 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1205910005483 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1205910005484 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1205910005485 phosphogluconate dehydratase; Validated; Region: PRK09054 1205910005486 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1205910005487 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1205910005488 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1205910005489 active site 1205910005490 intersubunit interface [polypeptide binding]; other site 1205910005491 catalytic residue [active] 1205910005492 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1205910005493 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910005494 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910005495 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1205910005496 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1205910005497 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1205910005498 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910005499 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1205910005500 Walker A/P-loop; other site 1205910005501 ATP binding site [chemical binding]; other site 1205910005502 Q-loop/lid; other site 1205910005503 ABC transporter signature motif; other site 1205910005504 Walker B; other site 1205910005505 D-loop; other site 1205910005506 H-loop/switch region; other site 1205910005507 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910005508 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910005509 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910005510 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1205910005511 Walker A/P-loop; other site 1205910005512 ATP binding site [chemical binding]; other site 1205910005513 Q-loop/lid; other site 1205910005514 ABC transporter signature motif; other site 1205910005515 Walker B; other site 1205910005516 D-loop; other site 1205910005517 H-loop/switch region; other site 1205910005518 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1205910005519 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1205910005520 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 1205910005521 dimer interface [polypeptide binding]; other site 1205910005522 putative metal binding site [ion binding]; other site 1205910005523 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1205910005524 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1205910005525 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910005526 Walker A/P-loop; other site 1205910005527 ATP binding site [chemical binding]; other site 1205910005528 Q-loop/lid; other site 1205910005529 ABC transporter signature motif; other site 1205910005530 Walker B; other site 1205910005531 D-loop; other site 1205910005532 H-loop/switch region; other site 1205910005533 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1205910005534 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1205910005535 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910005536 Q-loop/lid; other site 1205910005537 ABC transporter signature motif; other site 1205910005538 Walker B; other site 1205910005539 D-loop; other site 1205910005540 H-loop/switch region; other site 1205910005541 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1205910005542 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1205910005543 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1205910005544 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1205910005545 active site 1205910005546 Zn binding site [ion binding]; other site 1205910005547 Thiostrepton-resistance methylase, N terminus; Region: TSNR_N; pfam04705 1205910005548 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1205910005549 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1205910005550 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1205910005551 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205910005552 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1205910005553 radical SAM/SPASM domain protein, GRRM system; Region: rSAM_GlyRichRpt; TIGR04261 1205910005554 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205910005555 Coenzyme A binding pocket [chemical binding]; other site 1205910005556 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910005557 non-specific DNA binding site [nucleotide binding]; other site 1205910005558 salt bridge; other site 1205910005559 sequence-specific DNA binding site [nucleotide binding]; other site 1205910005560 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1205910005561 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1205910005562 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1205910005563 DDE superfamily endonuclease; Region: DDE_5; pfam13546 1205910005564 Herpesvirus UL17 protein; Region: Herpes_UL17; pfam04559 1205910005565 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 1205910005566 LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793 1205910005567 active site 1205910005568 zinc binding site [ion binding]; other site 1205910005569 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 1205910005570 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 1205910005571 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 1205910005572 FxLD family lantipeptide; Region: LD_lanti_pre; TIGR04363 1205910005573 methyltransferase, FxLD system; Region: methyltran_FxLD; TIGR04364 1205910005574 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910005575 S-adenosylmethionine binding site [chemical binding]; other site 1205910005576 Helix-turn-helix domain; Region: HTH_31; pfam13560 1205910005577 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910005578 S-adenosylmethionine binding site [chemical binding]; other site 1205910005579 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1205910005580 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1205910005581 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1205910005582 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910005583 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1205910005584 non-specific DNA binding site [nucleotide binding]; other site 1205910005585 salt bridge; other site 1205910005586 sequence-specific DNA binding site [nucleotide binding]; other site 1205910005587 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1205910005588 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1205910005589 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910005590 non-specific DNA binding site [nucleotide binding]; other site 1205910005591 salt bridge; other site 1205910005592 sequence-specific DNA binding site [nucleotide binding]; other site 1205910005593 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1205910005594 DNA binding residues [nucleotide binding] 1205910005595 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1205910005596 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 1205910005597 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1205910005598 Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631 1205910005599 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1205910005600 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1205910005601 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630 1205910005602 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1205910005603 catalytic loop [active] 1205910005604 iron binding site [ion binding]; other site 1205910005605 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1205910005606 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1205910005607 Histidine kinase; Region: HisKA_3; pfam07730 1205910005608 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1205910005609 ATP binding site [chemical binding]; other site 1205910005610 Mg2+ binding site [ion binding]; other site 1205910005611 G-X-G motif; other site 1205910005612 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205910005613 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910005614 active site 1205910005615 phosphorylation site [posttranslational modification] 1205910005616 intermolecular recognition site; other site 1205910005617 dimerization interface [polypeptide binding]; other site 1205910005618 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205910005619 DNA binding residues [nucleotide binding] 1205910005620 dimerization interface [polypeptide binding]; other site 1205910005621 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1205910005622 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1205910005623 Walker A/P-loop; other site 1205910005624 ATP binding site [chemical binding]; other site 1205910005625 Q-loop/lid; other site 1205910005626 ABC transporter signature motif; other site 1205910005627 Walker B; other site 1205910005628 D-loop; other site 1205910005629 H-loop/switch region; other site 1205910005630 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1205910005631 active site 1205910005632 catalytic residues [active] 1205910005633 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1205910005634 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205910005635 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205910005636 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1205910005637 Protein of unknown function (DUF690); Region: DUF690; cl04939 1205910005638 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1205910005639 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1205910005640 Protein of unknown function (DUF3584); Region: DUF3584; pfam12128 1205910005641 Right handed beta helix region; Region: Beta_helix; pfam13229 1205910005642 Right handed beta helix region; Region: Beta_helix; pfam13229 1205910005643 Right handed beta helix region; Region: Beta_helix; pfam13229 1205910005644 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1205910005645 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205910005646 Walker A motif; other site 1205910005647 ATP binding site [chemical binding]; other site 1205910005648 Walker B motif; other site 1205910005649 arginine finger; other site 1205910005650 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1205910005651 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205910005652 Walker A motif; other site 1205910005653 ATP binding site [chemical binding]; other site 1205910005654 Walker B motif; other site 1205910005655 arginine finger; other site 1205910005656 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1205910005657 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1205910005658 DNA binding residues [nucleotide binding] 1205910005659 hypothetical protein; Provisional; Region: PRK09266 1205910005660 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1205910005661 substrate-cofactor binding pocket; other site 1205910005662 homodimer interface [polypeptide binding]; other site 1205910005663 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910005664 catalytic residue [active] 1205910005665 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 1205910005666 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1205910005667 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1205910005668 Walker A/P-loop; other site 1205910005669 ATP binding site [chemical binding]; other site 1205910005670 Q-loop/lid; other site 1205910005671 ABC transporter signature motif; other site 1205910005672 Walker B; other site 1205910005673 D-loop; other site 1205910005674 H-loop/switch region; other site 1205910005675 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1205910005676 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205910005677 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205910005678 DNA binding residues [nucleotide binding] 1205910005679 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1205910005680 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205910005681 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910005682 homodimer interface [polypeptide binding]; other site 1205910005683 catalytic residue [active] 1205910005684 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1205910005685 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1205910005686 hinge; other site 1205910005687 active site 1205910005688 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1205910005689 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1205910005690 ATP binding site [chemical binding]; other site 1205910005691 active site 1205910005692 substrate binding site [chemical binding]; other site 1205910005693 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1205910005694 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1205910005695 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1205910005696 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1205910005697 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1205910005698 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1205910005699 GDP-binding site [chemical binding]; other site 1205910005700 ACT binding site; other site 1205910005701 IMP binding site; other site 1205910005702 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1205910005703 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1205910005704 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1205910005705 active site 1205910005706 intersubunit interface [polypeptide binding]; other site 1205910005707 zinc binding site [ion binding]; other site 1205910005708 Na+ binding site [ion binding]; other site 1205910005709 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1205910005710 active site 1205910005711 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 1205910005712 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1205910005713 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1205910005714 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1205910005715 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205910005716 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1205910005717 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205910005718 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205910005719 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1205910005720 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1205910005721 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1205910005722 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 1205910005723 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 1205910005724 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1205910005725 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1205910005726 DNA binding residues [nucleotide binding] 1205910005727 Putative zinc-finger; Region: zf-HC2; pfam13490 1205910005728 LabA_like proteins; Region: LabA_like; cd06167 1205910005729 putative metal binding site [ion binding]; other site 1205910005730 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1205910005731 ribonucleoside-diphosphate reductase, alpha subunit; Region: NrdE_NrdA; TIGR02506 1205910005732 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1205910005733 active site 1205910005734 dimer interface [polypeptide binding]; other site 1205910005735 catalytic residues [active] 1205910005736 effector binding site; other site 1205910005737 R2 peptide binding site; other site 1205910005738 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1205910005739 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1205910005740 dimer interface [polypeptide binding]; other site 1205910005741 putative radical transfer pathway; other site 1205910005742 diiron center [ion binding]; other site 1205910005743 tyrosyl radical; other site 1205910005744 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205910005745 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205910005746 active site 1205910005747 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1205910005748 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1205910005749 Na binding site [ion binding]; other site 1205910005750 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 1205910005751 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1205910005752 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1205910005753 homodimer interface [polypeptide binding]; other site 1205910005754 NAD binding pocket [chemical binding]; other site 1205910005755 ATP binding pocket [chemical binding]; other site 1205910005756 Mg binding site [ion binding]; other site 1205910005757 active-site loop [active] 1205910005758 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1205910005759 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205910005760 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 1205910005761 classical (c) SDRs; Region: SDR_c; cd05233 1205910005762 NAD(P) binding site [chemical binding]; other site 1205910005763 active site 1205910005764 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 1205910005765 putative active cleft [active] 1205910005766 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1205910005767 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1205910005768 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1205910005769 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1205910005770 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205910005771 Cytochrome P450; Region: p450; cl12078 1205910005772 MoxR-like ATPases [General function prediction only]; Region: COG0714 1205910005773 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1205910005774 Walker A motif; other site 1205910005775 ATP binding site [chemical binding]; other site 1205910005776 Walker B motif; other site 1205910005777 arginine finger; other site 1205910005778 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 1205910005779 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1205910005780 metal ion-dependent adhesion site (MIDAS); other site 1205910005781 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1205910005782 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1205910005783 ligand binding site [chemical binding]; other site 1205910005784 flexible hinge region; other site 1205910005785 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1205910005786 putative switch regulator; other site 1205910005787 non-specific DNA interactions [nucleotide binding]; other site 1205910005788 DNA binding site [nucleotide binding] 1205910005789 sequence specific DNA binding site [nucleotide binding]; other site 1205910005790 putative cAMP binding site [chemical binding]; other site 1205910005791 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1205910005792 Predicted membrane protein [Function unknown]; Region: COG4129 1205910005793 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1205910005794 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1205910005795 Predicted type IV restriction endonuclease [Defense mechanisms]; Region: COG2810 1205910005796 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1205910005797 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1205910005798 Walker A/P-loop; other site 1205910005799 ATP binding site [chemical binding]; other site 1205910005800 Q-loop/lid; other site 1205910005801 ABC transporter signature motif; other site 1205910005802 Walker B; other site 1205910005803 D-loop; other site 1205910005804 H-loop/switch region; other site 1205910005805 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 1205910005806 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 1205910005807 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 1205910005808 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 1205910005809 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 1205910005810 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1205910005811 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1205910005812 DNA binding residues [nucleotide binding] 1205910005813 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1205910005814 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1205910005815 trimer interface [polypeptide binding]; other site 1205910005816 active site 1205910005817 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1205910005818 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1205910005819 Walker A/P-loop; other site 1205910005820 ATP binding site [chemical binding]; other site 1205910005821 Q-loop/lid; other site 1205910005822 ABC transporter signature motif; other site 1205910005823 Walker B; other site 1205910005824 D-loop; other site 1205910005825 H-loop/switch region; other site 1205910005826 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910005827 dimer interface [polypeptide binding]; other site 1205910005828 conserved gate region; other site 1205910005829 ABC-ATPase subunit interface; other site 1205910005830 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1205910005831 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 1205910005832 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1205910005833 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1205910005834 Rhomboid family; Region: Rhomboid; pfam01694 1205910005835 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1205910005836 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1205910005837 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1205910005838 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910005839 dimer interface [polypeptide binding]; other site 1205910005840 conserved gate region; other site 1205910005841 putative PBP binding loops; other site 1205910005842 ABC-ATPase subunit interface; other site 1205910005843 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1205910005844 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1205910005845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910005846 dimer interface [polypeptide binding]; other site 1205910005847 conserved gate region; other site 1205910005848 putative PBP binding loops; other site 1205910005849 ABC-ATPase subunit interface; other site 1205910005850 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1205910005851 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1205910005852 Walker A/P-loop; other site 1205910005853 ATP binding site [chemical binding]; other site 1205910005854 Q-loop/lid; other site 1205910005855 ABC transporter signature motif; other site 1205910005856 Walker B; other site 1205910005857 D-loop; other site 1205910005858 H-loop/switch region; other site 1205910005859 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1205910005860 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1205910005861 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1205910005862 Walker A/P-loop; other site 1205910005863 ATP binding site [chemical binding]; other site 1205910005864 Q-loop/lid; other site 1205910005865 ABC transporter signature motif; other site 1205910005866 Walker B; other site 1205910005867 D-loop; other site 1205910005868 H-loop/switch region; other site 1205910005869 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1205910005870 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 1205910005871 ABC1 family; Region: ABC1; cl17513 1205910005872 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1205910005873 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1205910005874 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910005875 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1205910005876 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1205910005877 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1205910005878 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1205910005879 DoxX; Region: DoxX; pfam07681 1205910005880 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 1205910005881 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205910005882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910005883 active site 1205910005884 phosphorylation site [posttranslational modification] 1205910005885 intermolecular recognition site; other site 1205910005886 dimerization interface [polypeptide binding]; other site 1205910005887 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205910005888 DNA binding site [nucleotide binding] 1205910005889 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1205910005890 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1205910005891 transmembrane helices; other site 1205910005892 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1205910005893 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1205910005894 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1205910005895 transmembrane helices; other site 1205910005896 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1205910005897 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 1205910005898 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 1205910005899 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 1205910005900 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1205910005901 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 1205910005902 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 1205910005903 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1205910005904 Domain of unknown function (DUF4040); Region: DUF4040; pfam13244 1205910005905 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1205910005906 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1205910005907 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1205910005908 catalytic site [active] 1205910005909 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1205910005910 Phosphotransferase enzyme family; Region: APH; pfam01636 1205910005911 active site 1205910005912 substrate binding site [chemical binding]; other site 1205910005913 ATP binding site [chemical binding]; other site 1205910005914 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1205910005915 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1205910005916 Walker A/P-loop; other site 1205910005917 ATP binding site [chemical binding]; other site 1205910005918 Q-loop/lid; other site 1205910005919 ABC transporter signature motif; other site 1205910005920 Walker B; other site 1205910005921 D-loop; other site 1205910005922 H-loop/switch region; other site 1205910005923 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1205910005924 ABC-ATPase subunit interface; other site 1205910005925 dimer interface [polypeptide binding]; other site 1205910005926 putative PBP binding regions; other site 1205910005927 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1205910005928 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1205910005929 ABC-ATPase subunit interface; other site 1205910005930 dimer interface [polypeptide binding]; other site 1205910005931 putative PBP binding regions; other site 1205910005932 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1205910005933 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1205910005934 intersubunit interface [polypeptide binding]; other site 1205910005935 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205910005936 Protein kinase domain; Region: Pkinase; pfam00069 1205910005937 active site 1205910005938 ATP binding site [chemical binding]; other site 1205910005939 substrate binding site [chemical binding]; other site 1205910005940 activation loop (A-loop); other site 1205910005941 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 1205910005942 NMT1/THI5 like; Region: NMT1; pfam09084 1205910005943 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910005944 dimer interface [polypeptide binding]; other site 1205910005945 conserved gate region; other site 1205910005946 ABC-ATPase subunit interface; other site 1205910005947 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1205910005948 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1205910005949 Walker A/P-loop; other site 1205910005950 ATP binding site [chemical binding]; other site 1205910005951 Q-loop/lid; other site 1205910005952 ABC transporter signature motif; other site 1205910005953 Walker B; other site 1205910005954 D-loop; other site 1205910005955 H-loop/switch region; other site 1205910005956 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1205910005957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910005958 putative substrate translocation pore; other site 1205910005959 DinB superfamily; Region: DinB_2; pfam12867 1205910005960 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1205910005961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910005962 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1205910005963 MarR family; Region: MarR_2; pfam12802 1205910005964 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205910005965 dimerization interface [polypeptide binding]; other site 1205910005966 putative DNA binding site [nucleotide binding]; other site 1205910005967 putative Zn2+ binding site [ion binding]; other site 1205910005968 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 1205910005969 putative hydrophobic ligand binding site [chemical binding]; other site 1205910005970 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1205910005971 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1205910005972 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1205910005973 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1205910005974 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1205910005975 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1205910005976 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910005977 non-specific DNA binding site [nucleotide binding]; other site 1205910005978 salt bridge; other site 1205910005979 sequence-specific DNA binding site [nucleotide binding]; other site 1205910005980 Cupin domain; Region: Cupin_2; pfam07883 1205910005981 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1205910005982 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 1205910005983 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1205910005984 Na binding site [ion binding]; other site 1205910005985 putative substrate binding site [chemical binding]; other site 1205910005986 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1205910005987 active site 1205910005988 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205910005989 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205910005990 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1205910005991 Histidine kinase; Region: HisKA_3; pfam07730 1205910005992 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910005993 ATP binding site [chemical binding]; other site 1205910005994 Mg2+ binding site [ion binding]; other site 1205910005995 G-X-G motif; other site 1205910005996 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205910005997 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910005998 active site 1205910005999 phosphorylation site [posttranslational modification] 1205910006000 intermolecular recognition site; other site 1205910006001 dimerization interface [polypeptide binding]; other site 1205910006002 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205910006003 DNA binding residues [nucleotide binding] 1205910006004 dimerization interface [polypeptide binding]; other site 1205910006005 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1205910006006 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1205910006007 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1205910006008 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1205910006009 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1205910006010 helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422 1205910006011 DNA binding residues [nucleotide binding] 1205910006012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910006013 putative substrate translocation pore; other site 1205910006014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910006015 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1205910006016 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910006017 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1205910006018 putative substrate translocation pore; other site 1205910006019 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1205910006020 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205910006021 putative DNA binding site [nucleotide binding]; other site 1205910006022 dimerization interface [polypeptide binding]; other site 1205910006023 putative Zn2+ binding site [ion binding]; other site 1205910006024 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1205910006025 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1205910006026 D-pathway; other site 1205910006027 Low-spin heme binding site [chemical binding]; other site 1205910006028 Putative water exit pathway; other site 1205910006029 Binuclear center (active site) [active] 1205910006030 K-pathway; other site 1205910006031 Putative proton exit pathway; other site 1205910006032 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1205910006033 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1205910006034 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1205910006035 Serine hydrolase; Region: Ser_hydrolase; cl17834 1205910006036 Histidine kinase; Region: HisKA_3; pfam07730 1205910006037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910006038 ATP binding site [chemical binding]; other site 1205910006039 Mg2+ binding site [ion binding]; other site 1205910006040 G-X-G motif; other site 1205910006041 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205910006042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910006043 active site 1205910006044 phosphorylation site [posttranslational modification] 1205910006045 intermolecular recognition site; other site 1205910006046 dimerization interface [polypeptide binding]; other site 1205910006047 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205910006048 DNA binding residues [nucleotide binding] 1205910006049 dimerization interface [polypeptide binding]; other site 1205910006050 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1205910006051 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205910006052 putative DNA binding site [nucleotide binding]; other site 1205910006053 putative Zn2+ binding site [ion binding]; other site 1205910006054 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1205910006055 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1205910006056 D-pathway; other site 1205910006057 Putative ubiquinol binding site [chemical binding]; other site 1205910006058 Low-spin heme (heme b) binding site [chemical binding]; other site 1205910006059 Putative water exit pathway; other site 1205910006060 Binuclear center (heme o3/CuB) [ion binding]; other site 1205910006061 K-pathway; other site 1205910006062 Putative proton exit pathway; other site 1205910006063 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683 1205910006064 nudix motif; other site 1205910006065 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1205910006066 putative homotetramer interface [polypeptide binding]; other site 1205910006067 putative homodimer interface [polypeptide binding]; other site 1205910006068 putative allosteric switch controlling residues; other site 1205910006069 putative metal binding site [ion binding]; other site 1205910006070 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1205910006071 active site residue [active] 1205910006072 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1205910006073 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1205910006074 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1205910006075 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1205910006076 active site residue [active] 1205910006077 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1205910006078 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1205910006079 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1205910006080 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1205910006081 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205910006082 catalytic residue [active] 1205910006083 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1205910006084 PspC domain; Region: PspC; pfam04024 1205910006085 H+ Antiporter protein; Region: 2A0121; TIGR00900 1205910006086 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1205910006087 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1205910006088 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1205910006089 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1205910006090 active site 1205910006091 metal binding site [ion binding]; metal-binding site 1205910006092 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910006093 sequence-specific DNA binding site [nucleotide binding]; other site 1205910006094 salt bridge; other site 1205910006095 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 1205910006096 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1205910006097 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1205910006098 TAP-like protein; Region: Abhydrolase_4; pfam08386 1205910006099 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1205910006100 RNA binding surface [nucleotide binding]; other site 1205910006101 RRNA methyltransferase AviRa; Region: AviRa; pfam11599 1205910006102 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1205910006103 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910006104 putative substrate translocation pore; other site 1205910006105 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1205910006106 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1205910006107 [4Fe-4S] binding site [ion binding]; other site 1205910006108 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1205910006109 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1205910006110 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1205910006111 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1205910006112 molybdopterin cofactor binding site; other site 1205910006113 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1205910006114 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1205910006115 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1205910006116 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1205910006117 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1205910006118 amino acid carrier protein; Region: agcS; TIGR00835 1205910006119 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205910006120 Coenzyme A binding pocket [chemical binding]; other site 1205910006121 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1205910006122 metal-binding site [ion binding] 1205910006123 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1205910006124 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1205910006125 metal-binding site [ion binding] 1205910006126 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1205910006127 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205910006128 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205910006129 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205910006130 Cytochrome P450; Region: p450; cl12078 1205910006131 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205910006132 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205910006133 active site 1205910006134 ATP binding site [chemical binding]; other site 1205910006135 substrate binding site [chemical binding]; other site 1205910006136 activation loop (A-loop); other site 1205910006137 glutaminase; Provisional; Region: PRK00971 1205910006138 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1205910006139 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1205910006140 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 1205910006141 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910006142 catalytic residue [active] 1205910006143 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205910006144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910006145 active site 1205910006146 phosphorylation site [posttranslational modification] 1205910006147 intermolecular recognition site; other site 1205910006148 dimerization interface [polypeptide binding]; other site 1205910006149 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205910006150 DNA binding residues [nucleotide binding] 1205910006151 dimerization interface [polypeptide binding]; other site 1205910006152 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1205910006153 Histidine kinase; Region: HisKA_3; pfam07730 1205910006154 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205910006155 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1205910006156 NAD(P) binding site [chemical binding]; other site 1205910006157 active site 1205910006158 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205910006159 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205910006160 active site 1205910006161 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1205910006162 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910006163 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 1205910006164 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1205910006165 G1 box; other site 1205910006166 putative GEF interaction site [polypeptide binding]; other site 1205910006167 GTP/Mg2+ binding site [chemical binding]; other site 1205910006168 Switch I region; other site 1205910006169 G2 box; other site 1205910006170 G3 box; other site 1205910006171 Switch II region; other site 1205910006172 G4 box; other site 1205910006173 G5 box; other site 1205910006174 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1205910006175 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1205910006176 Citrate synthase; Region: Citrate_synt; pfam00285 1205910006177 oxalacetate binding site [chemical binding]; other site 1205910006178 citrylCoA binding site [chemical binding]; other site 1205910006179 coenzyme A binding site [chemical binding]; other site 1205910006180 catalytic triad [active] 1205910006181 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1205910006182 Predicted ATPase [General function prediction only]; Region: COG3911 1205910006183 AAA domain; Region: AAA_28; pfam13521 1205910006184 Protein kinase domain; Region: Pkinase; pfam00069 1205910006185 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205910006186 active site 1205910006187 ATP binding site [chemical binding]; other site 1205910006188 substrate binding site [chemical binding]; other site 1205910006189 activation loop (A-loop); other site 1205910006190 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1205910006191 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1205910006192 TPR motif; other site 1205910006193 binding surface 1205910006194 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 1205910006195 active site 1205910006196 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1205910006197 metal ion-dependent adhesion site (MIDAS); other site 1205910006198 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1205910006199 phosphopeptide binding site; other site 1205910006200 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1205910006201 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1205910006202 substrate binding pocket [chemical binding]; other site 1205910006203 membrane-bound complex binding site; other site 1205910006204 hinge residues; other site 1205910006205 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1205910006206 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205910006207 NAD(P) binding site [chemical binding]; other site 1205910006208 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205910006209 active site 1205910006210 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1205910006211 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 1205910006212 putative NAD(P) binding site [chemical binding]; other site 1205910006213 catalytic Zn binding site [ion binding]; other site 1205910006214 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205910006215 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910006216 active site 1205910006217 phosphorylation site [posttranslational modification] 1205910006218 intermolecular recognition site; other site 1205910006219 dimerization interface [polypeptide binding]; other site 1205910006220 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205910006221 DNA binding residues [nucleotide binding] 1205910006222 dimerization interface [polypeptide binding]; other site 1205910006223 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1205910006224 Histidine kinase; Region: HisKA_3; pfam07730 1205910006225 Predicted membrane protein [Function unknown]; Region: COG2311 1205910006226 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1205910006227 Ubiquitin-like proteins; Region: UBQ; cl00155 1205910006228 charged pocket; other site 1205910006229 hydrophobic patch; other site 1205910006230 BNR repeat-like domain; Region: BNR_2; pfam13088 1205910006231 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910006232 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1205910006233 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205910006234 substrate binding site [chemical binding]; other site 1205910006235 oxyanion hole (OAH) forming residues; other site 1205910006236 trimer interface [polypeptide binding]; other site 1205910006237 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1205910006238 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1205910006239 Histidine kinase; Region: HisKA_3; pfam07730 1205910006240 glycoside hydrolase family 64: laminaripentaose-producing, beta-1,3-glucanase (LPHase)-like; Region: GH64-LPHase-like; cd09216 1205910006241 substrate binding pocket [chemical binding]; other site 1205910006242 catalytic residues [active] 1205910006243 O-methyltransferase; Region: Methyltransf_2; pfam00891 1205910006244 YcfA-like protein; Region: YcfA; pfam07927 1205910006245 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1205910006246 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1205910006247 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1205910006248 NAD(P) binding site [chemical binding]; other site 1205910006249 catalytic residues [active] 1205910006250 Protein of unknown function (DUF779); Region: DUF779; pfam05610 1205910006251 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 1205910006252 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 1205910006253 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 1205910006254 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 1205910006255 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1205910006256 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 1205910006257 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 1205910006258 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1205910006259 Domain of unknown function (DUF4040); Region: DUF4040; pfam13244 1205910006260 MarR family; Region: MarR; pfam01047 1205910006261 Clp protease; Region: CLP_protease; pfam00574 1205910006262 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1205910006263 oligomer interface [polypeptide binding]; other site 1205910006264 active site residues [active] 1205910006265 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1205910006266 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1205910006267 oligomer interface [polypeptide binding]; other site 1205910006268 active site residues [active] 1205910006269 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1205910006270 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1205910006271 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1205910006272 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1205910006273 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1205910006274 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1205910006275 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1205910006276 nucleotide binding site/active site [active] 1205910006277 HIT family signature motif; other site 1205910006278 catalytic residue [active] 1205910006279 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1205910006280 EamA-like transporter family; Region: EamA; pfam00892 1205910006281 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1205910006282 MarR family; Region: MarR; pfam01047 1205910006283 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 1205910006284 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1205910006285 Amidase; Region: Amidase; cl11426 1205910006286 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1205910006287 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205910006288 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910006289 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1205910006290 Predicted membrane protein [Function unknown]; Region: COG2311 1205910006291 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1205910006292 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 1205910006293 TIGR03084 family protein; Region: TIGR03084 1205910006294 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1205910006295 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205910006296 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205910006297 active site 1205910006298 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910006299 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910006300 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1205910006301 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1205910006302 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1205910006303 Carbon starvation protein CstA; Region: CstA; pfam02554 1205910006304 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1205910006305 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1205910006306 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1205910006307 DTAP/Switch II; other site 1205910006308 Switch I; other site 1205910006309 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205910006310 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205910006311 active site 1205910006312 ATP binding site [chemical binding]; other site 1205910006313 substrate binding site [chemical binding]; other site 1205910006314 activation loop (A-loop); other site 1205910006315 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1205910006316 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1205910006317 metal-binding site [ion binding] 1205910006318 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 1205910006319 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 1205910006320 putative active site [active] 1205910006321 putative metal binding site [ion binding]; other site 1205910006322 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1205910006323 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1205910006324 Bacterial transcriptional regulator; Region: IclR; pfam01614 1205910006325 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1205910006326 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 1205910006327 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1205910006328 metal binding site [ion binding]; metal-binding site 1205910006329 substrate binding pocket [chemical binding]; other site 1205910006330 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1205910006331 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1205910006332 GH3 auxin-responsive promoter; Region: GH3; pfam03321 1205910006333 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1205910006334 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1205910006335 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1205910006336 hypothetical protein; Provisional; Region: PRK07206 1205910006337 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1205910006338 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205910006339 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1205910006340 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910006341 homodimer interface [polypeptide binding]; other site 1205910006342 catalytic residue [active] 1205910006343 YCII-related domain; Region: YCII; pfam03795 1205910006344 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1205910006345 classical (c) SDRs; Region: SDR_c; cd05233 1205910006346 NAD(P) binding site [chemical binding]; other site 1205910006347 active site 1205910006348 H+ Antiporter protein; Region: 2A0121; TIGR00900 1205910006349 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910006350 putative substrate translocation pore; other site 1205910006351 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1205910006352 putative di-iron ligands [ion binding]; other site 1205910006353 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1205910006354 B12 binding site [chemical binding]; other site 1205910006355 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cl02025 1205910006356 substrate binding site [chemical binding]; other site 1205910006357 B12 cofactor binding site [chemical binding]; other site 1205910006358 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 1205910006359 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 1205910006360 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1205910006361 hypothetical protein; Provisional; Region: PRK07906 1205910006362 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1205910006363 putative metal binding site [ion binding]; other site 1205910006364 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1205910006365 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1205910006366 active site 1205910006367 interdomain interaction site; other site 1205910006368 putative metal-binding site [ion binding]; other site 1205910006369 nucleotide binding site [chemical binding]; other site 1205910006370 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1205910006371 domain I; other site 1205910006372 phosphate binding site [ion binding]; other site 1205910006373 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1205910006374 domain II; other site 1205910006375 domain III; other site 1205910006376 nucleotide binding site [chemical binding]; other site 1205910006377 DNA binding groove [nucleotide binding] 1205910006378 catalytic site [active] 1205910006379 domain IV; other site 1205910006380 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1205910006381 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1205910006382 thymidylate kinase; Validated; Region: tmk; PRK00698 1205910006383 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1205910006384 TMP-binding site; other site 1205910006385 ATP-binding site [chemical binding]; other site 1205910006386 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205910006387 TAP-like protein; Region: Abhydrolase_4; pfam08386 1205910006388 Right handed beta helix region; Region: Beta_helix; pfam13229 1205910006389 Right handed beta helix region; Region: Beta_helix; pfam13229 1205910006390 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1205910006391 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205910006392 Walker A motif; other site 1205910006393 ATP binding site [chemical binding]; other site 1205910006394 Walker B motif; other site 1205910006395 arginine finger; other site 1205910006396 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1205910006397 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1205910006398 dimer interface [polypeptide binding]; other site 1205910006399 substrate binding site [chemical binding]; other site 1205910006400 metal binding sites [ion binding]; metal-binding site 1205910006401 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1205910006402 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1205910006403 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1205910006404 putative hydrolase; Region: TIGR03624 1205910006405 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1205910006406 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1205910006407 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1205910006408 active site 1205910006409 FtsH Extracellular; Region: FtsH_ext; pfam06480 1205910006410 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1205910006411 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205910006412 Walker A motif; other site 1205910006413 ATP binding site [chemical binding]; other site 1205910006414 Walker B motif; other site 1205910006415 arginine finger; other site 1205910006416 Peptidase family M41; Region: Peptidase_M41; pfam01434 1205910006417 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1205910006418 homodecamer interface [polypeptide binding]; other site 1205910006419 GTP cyclohydrolase I; Provisional; Region: PLN03044 1205910006420 active site 1205910006421 putative catalytic site residues [active] 1205910006422 zinc binding site [ion binding]; other site 1205910006423 GTP-CH-I/GFRP interaction surface; other site 1205910006424 dihydropteroate synthase; Region: DHPS; TIGR01496 1205910006425 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1205910006426 substrate binding pocket [chemical binding]; other site 1205910006427 dimer interface [polypeptide binding]; other site 1205910006428 inhibitor binding site; inhibition site 1205910006429 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1205910006430 SnoaL-like domain; Region: SnoaL_3; pfam13474 1205910006431 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1205910006432 homooctamer interface [polypeptide binding]; other site 1205910006433 active site 1205910006434 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1205910006435 catalytic center binding site [active] 1205910006436 ATP binding site [chemical binding]; other site 1205910006437 Bacterial PH domain; Region: DUF304; cl01348 1205910006438 Bacterial PH domain; Region: DUF304; pfam03703 1205910006439 Bacterial PH domain; Region: DUF304; pfam03703 1205910006440 Bacterial PH domain; Region: DUF304; cl01348 1205910006441 Rossmann-like domain; Region: Rossmann-like; pfam10727 1205910006442 Uncharacterized conserved protein [Function unknown]; Region: COG5495 1205910006443 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1205910006444 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 1205910006445 active site 1205910006446 nucleotide binding site [chemical binding]; other site 1205910006447 HIGH motif; other site 1205910006448 KMSKS motif; other site 1205910006449 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 1205910006450 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1205910006451 dimerization interface [polypeptide binding]; other site 1205910006452 active site 1205910006453 pantothenate kinase; Reviewed; Region: PRK13318 1205910006454 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1205910006455 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1205910006456 dimer interface [polypeptide binding]; other site 1205910006457 putative anticodon binding site; other site 1205910006458 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1205910006459 motif 1; other site 1205910006460 dimer interface [polypeptide binding]; other site 1205910006461 active site 1205910006462 motif 2; other site 1205910006463 motif 3; other site 1205910006464 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1205910006465 dimerization interface [polypeptide binding]; other site 1205910006466 DNA binding residues [nucleotide binding] 1205910006467 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205910006468 Coenzyme A binding pocket [chemical binding]; other site 1205910006469 Lsr2; Region: Lsr2; pfam11774 1205910006470 Clp protease ATP binding subunit; Region: clpC; CHL00095 1205910006471 Clp amino terminal domain; Region: Clp_N; pfam02861 1205910006472 Clp amino terminal domain; Region: Clp_N; pfam02861 1205910006473 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205910006474 Walker A motif; other site 1205910006475 ATP binding site [chemical binding]; other site 1205910006476 Walker B motif; other site 1205910006477 arginine finger; other site 1205910006478 UvrB/uvrC motif; Region: UVR; pfam02151 1205910006479 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205910006480 Walker A motif; other site 1205910006481 ATP binding site [chemical binding]; other site 1205910006482 Walker B motif; other site 1205910006483 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1205910006484 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 1205910006485 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1205910006486 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1205910006487 minor groove reading motif; other site 1205910006488 helix-hairpin-helix signature motif; other site 1205910006489 substrate binding pocket [chemical binding]; other site 1205910006490 active site 1205910006491 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1205910006492 Subtilisin inhibitor-like; Region: SSI; cl11594 1205910006493 DNA repair protein RadA; Provisional; Region: PRK11823 1205910006494 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1205910006495 Walker A motif; other site 1205910006496 ATP binding site [chemical binding]; other site 1205910006497 Walker B motif; other site 1205910006498 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1205910006499 active site 1205910006500 catalytic triad [active] 1205910006501 oxyanion hole [active] 1205910006502 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1205910006503 NlpC/P60 family; Region: NLPC_P60; pfam00877 1205910006504 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1205910006505 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1205910006506 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1205910006507 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1205910006508 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1205910006509 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1205910006510 active site 1205910006511 Zn binding site [ion binding]; other site 1205910006512 DNA binding domain, excisionase family; Region: excise; TIGR01764 1205910006513 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1205910006514 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1205910006515 catalytic residues [active] 1205910006516 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1205910006517 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1205910006518 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1205910006519 ResB-like family; Region: ResB; pfam05140 1205910006520 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1205910006521 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1205910006522 DNA binding residues [nucleotide binding] 1205910006523 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 1205910006524 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1205910006525 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910006526 S-adenosylmethionine binding site [chemical binding]; other site 1205910006527 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1205910006528 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205910006529 NADH dehydrogenase subunit A; Validated; Region: PRK07928 1205910006530 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1205910006531 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 1205910006532 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1205910006533 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 1205910006534 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1205910006535 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1205910006536 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1205910006537 putative dimer interface [polypeptide binding]; other site 1205910006538 [2Fe-2S] cluster binding site [ion binding]; other site 1205910006539 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1205910006540 SLBB domain; Region: SLBB; pfam10531 1205910006541 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1205910006542 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1205910006543 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1205910006544 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1205910006545 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1205910006546 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1205910006547 4Fe-4S binding domain; Region: Fer4; pfam00037 1205910006548 4Fe-4S binding domain; Region: Fer4; pfam00037 1205910006549 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1205910006550 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1205910006551 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1205910006552 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1205910006553 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1205910006554 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1205910006555 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1205910006556 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1205910006557 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1205910006558 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1205910006559 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1205910006560 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1205910006561 substrate binding pocket [chemical binding]; other site 1205910006562 chain length determination region; other site 1205910006563 substrate-Mg2+ binding site; other site 1205910006564 catalytic residues [active] 1205910006565 aspartate-rich region 1; other site 1205910006566 active site lid residues [active] 1205910006567 aspartate-rich region 2; other site 1205910006568 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205910006569 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1205910006570 active site 1205910006571 ATP binding site [chemical binding]; other site 1205910006572 substrate binding site [chemical binding]; other site 1205910006573 activation loop (A-loop); other site 1205910006574 Protein kinase domain; Region: Pkinase; pfam00069 1205910006575 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205910006576 active site 1205910006577 ATP binding site [chemical binding]; other site 1205910006578 substrate binding site [chemical binding]; other site 1205910006579 activation loop (A-loop); other site 1205910006580 hypothetical protein; Provisional; Region: PRK07588 1205910006581 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1205910006582 rarD protein; Region: rarD; TIGR00688 1205910006583 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1205910006584 UDP-N-acetylmuramoylalanine--D-glutamate ligase; Region: murD; TIGR01087 1205910006585 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910006586 S-adenosylmethionine binding site [chemical binding]; other site 1205910006587 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205910006588 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1205910006589 active site 1205910006590 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1205910006591 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205910006592 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1205910006593 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1205910006594 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 1205910006595 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1205910006596 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1205910006597 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1205910006598 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910006599 ATP binding site [chemical binding]; other site 1205910006600 Mg2+ binding site [ion binding]; other site 1205910006601 G-X-G motif; other site 1205910006602 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910006603 active site 1205910006604 dimerization interface [polypeptide binding]; other site 1205910006605 HTH domain; Region: HTH_11; cl17392 1205910006606 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205910006607 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1205910006608 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205910006609 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205910006610 DNA binding residues [nucleotide binding] 1205910006611 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1205910006612 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1205910006613 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205910006614 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1205910006615 NAD(P) binding site [chemical binding]; other site 1205910006616 active site 1205910006617 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1205910006618 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1205910006619 TPP-binding site [chemical binding]; other site 1205910006620 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1205910006621 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1205910006622 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1205910006623 dimer interface [polypeptide binding]; other site 1205910006624 PYR/PP interface [polypeptide binding]; other site 1205910006625 TPP binding site [chemical binding]; other site 1205910006626 substrate binding site [chemical binding]; other site 1205910006627 Peptidase family M48; Region: Peptidase_M48; cl12018 1205910006628 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1205910006629 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1205910006630 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 1205910006631 Protein of unknown function (DUF2398); Region: DUF2398; cl09875 1205910006632 TIGR02680 family protein; Region: TIGR02680 1205910006633 TIGR02680 family protein; Region: TIGR02680 1205910006634 AAA domain; Region: AAA_23; pfam13476 1205910006635 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910006636 Walker A/P-loop; other site 1205910006637 ATP binding site [chemical binding]; other site 1205910006638 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910006639 ABC transporter signature motif; other site 1205910006640 Walker B; other site 1205910006641 D-loop; other site 1205910006642 H-loop/switch region; other site 1205910006643 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1205910006644 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1205910006645 active site 1205910006646 catalytic site [active] 1205910006647 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1205910006648 active site 1205910006649 catalytic site [active] 1205910006650 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1205910006651 FAD binding domain; Region: FAD_binding_4; pfam01565 1205910006652 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1205910006653 Predicted membrane protein [Function unknown]; Region: COG2119 1205910006654 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1205910006655 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1205910006656 adenosine deaminase; Provisional; Region: PRK09358 1205910006657 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1205910006658 active site 1205910006659 aspartate aminotransferase; Provisional; Region: PRK05764 1205910006660 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205910006661 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910006662 homodimer interface [polypeptide binding]; other site 1205910006663 catalytic residue [active] 1205910006664 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 1205910006665 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1205910006666 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1205910006667 putative homodimer interface [polypeptide binding]; other site 1205910006668 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1205910006669 heterodimer interface [polypeptide binding]; other site 1205910006670 homodimer interface [polypeptide binding]; other site 1205910006671 Ribosomal protein L11/L12; Region: RL11; smart00649 1205910006672 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1205910006673 putative thiostrepton binding site; other site 1205910006674 23S rRNA interface [nucleotide binding]; other site 1205910006675 L7/L12 interface [polypeptide binding]; other site 1205910006676 L25 interface [polypeptide binding]; other site 1205910006677 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1205910006678 mRNA/rRNA interface [nucleotide binding]; other site 1205910006679 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1205910006680 23S rRNA interface [nucleotide binding]; other site 1205910006681 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1205910006682 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1205910006683 core dimer interface [polypeptide binding]; other site 1205910006684 peripheral dimer interface [polypeptide binding]; other site 1205910006685 L10 interface [polypeptide binding]; other site 1205910006686 L11 interface [polypeptide binding]; other site 1205910006687 putative EF-Tu interaction site [polypeptide binding]; other site 1205910006688 putative EF-G interaction site [polypeptide binding]; other site 1205910006689 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1205910006690 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1205910006691 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1205910006692 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1205910006693 RPB1 interaction site [polypeptide binding]; other site 1205910006694 RPB10 interaction site [polypeptide binding]; other site 1205910006695 RPB11 interaction site [polypeptide binding]; other site 1205910006696 RPB3 interaction site [polypeptide binding]; other site 1205910006697 RPB12 interaction site [polypeptide binding]; other site 1205910006698 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1205910006699 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1205910006700 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1205910006701 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1205910006702 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1205910006703 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1205910006704 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1205910006705 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1205910006706 G-loop; other site 1205910006707 DNA binding site [nucleotide binding] 1205910006708 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1205910006709 YcaO-like family; Region: YcaO; pfam02624 1205910006710 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 1205910006711 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 1205910006712 FMN binding site [chemical binding]; other site 1205910006713 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1205910006714 dimer interface [polypeptide binding]; other site 1205910006715 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1205910006716 FMN binding site [chemical binding]; other site 1205910006717 dimer interface [polypeptide binding]; other site 1205910006718 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 1205910006719 YcaO-like family; Region: YcaO; pfam02624 1205910006720 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 1205910006721 Thiostrepton-resistance methylase, N terminus; Region: TSNR_N; pfam04705 1205910006722 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1205910006723 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1205910006724 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1205910006725 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1205910006726 active site 1205910006727 NAD binding site [chemical binding]; other site 1205910006728 metal binding site [ion binding]; metal-binding site 1205910006729 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 1205910006730 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 1205910006731 SpaB C-terminal domain; Region: SpaB_C; pfam14028 1205910006732 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1205910006733 S17 interaction site [polypeptide binding]; other site 1205910006734 S8 interaction site; other site 1205910006735 16S rRNA interaction site [nucleotide binding]; other site 1205910006736 streptomycin interaction site [chemical binding]; other site 1205910006737 23S rRNA interaction site [nucleotide binding]; other site 1205910006738 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1205910006739 30S ribosomal protein S7; Validated; Region: PRK05302 1205910006740 elongation factor G; Reviewed; Region: PRK00007 1205910006741 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1205910006742 G1 box; other site 1205910006743 putative GEF interaction site [polypeptide binding]; other site 1205910006744 GTP/Mg2+ binding site [chemical binding]; other site 1205910006745 Switch I region; other site 1205910006746 G2 box; other site 1205910006747 G3 box; other site 1205910006748 Switch II region; other site 1205910006749 G4 box; other site 1205910006750 G5 box; other site 1205910006751 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1205910006752 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1205910006753 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1205910006754 elongation factor Tu; Reviewed; Region: PRK00049 1205910006755 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1205910006756 G1 box; other site 1205910006757 GEF interaction site [polypeptide binding]; other site 1205910006758 GTP/Mg2+ binding site [chemical binding]; other site 1205910006759 Switch I region; other site 1205910006760 G2 box; other site 1205910006761 G3 box; other site 1205910006762 Switch II region; other site 1205910006763 G4 box; other site 1205910006764 G5 box; other site 1205910006765 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1205910006766 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1205910006767 Antibiotic Binding Site [chemical binding]; other site 1205910006768 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1205910006769 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1205910006770 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1205910006771 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1205910006772 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1205910006773 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1205910006774 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1205910006775 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1205910006776 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1205910006777 protein-rRNA interface [nucleotide binding]; other site 1205910006778 putative translocon binding site; other site 1205910006779 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 1205910006780 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1205910006781 G-X-X-G motif; other site 1205910006782 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1205910006783 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1205910006784 23S rRNA interface [nucleotide binding]; other site 1205910006785 5S rRNA interface [nucleotide binding]; other site 1205910006786 putative antibiotic binding site [chemical binding]; other site 1205910006787 L25 interface [polypeptide binding]; other site 1205910006788 L27 interface [polypeptide binding]; other site 1205910006789 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1205910006790 putative translocon interaction site; other site 1205910006791 23S rRNA interface [nucleotide binding]; other site 1205910006792 signal recognition particle (SRP54) interaction site; other site 1205910006793 L23 interface [polypeptide binding]; other site 1205910006794 trigger factor interaction site; other site 1205910006795 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1205910006796 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1205910006797 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1205910006798 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1205910006799 RNA binding site [nucleotide binding]; other site 1205910006800 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1205910006801 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1205910006802 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1205910006803 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1205910006804 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1205910006805 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1205910006806 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1205910006807 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1205910006808 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1205910006809 5S rRNA interface [nucleotide binding]; other site 1205910006810 L27 interface [polypeptide binding]; other site 1205910006811 23S rRNA interface [nucleotide binding]; other site 1205910006812 L5 interface [polypeptide binding]; other site 1205910006813 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1205910006814 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1205910006815 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1205910006816 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1205910006817 23S rRNA binding site [nucleotide binding]; other site 1205910006818 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1205910006819 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1205910006820 SecY translocase; Region: SecY; pfam00344 1205910006821 adenylate kinase; Reviewed; Region: adk; PRK00279 1205910006822 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1205910006823 AMP-binding site [chemical binding]; other site 1205910006824 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1205910006825 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1205910006826 active site 1205910006827 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1205910006828 2TM domain; Region: 2TM; pfam13239 1205910006829 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1205910006830 rRNA binding site [nucleotide binding]; other site 1205910006831 predicted 30S ribosome binding site; other site 1205910006832 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1205910006833 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1205910006834 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1205910006835 30S ribosomal protein S11; Validated; Region: PRK05309 1205910006836 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1205910006837 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1205910006838 alphaNTD homodimer interface [polypeptide binding]; other site 1205910006839 alphaNTD - beta interaction site [polypeptide binding]; other site 1205910006840 alphaNTD - beta' interaction site [polypeptide binding]; other site 1205910006841 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1205910006842 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1205910006843 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1205910006844 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1205910006845 dimerization interface 3.5A [polypeptide binding]; other site 1205910006846 active site 1205910006847 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1205910006848 23S rRNA interface [nucleotide binding]; other site 1205910006849 L3 interface [polypeptide binding]; other site 1205910006850 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1205910006851 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1205910006852 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1205910006853 active site 1205910006854 substrate binding site [chemical binding]; other site 1205910006855 metal binding site [ion binding]; metal-binding site 1205910006856 ROK family; Region: ROK; pfam00480 1205910006857 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1205910006858 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1205910006859 putative active site [active] 1205910006860 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205910006861 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1205910006862 NAD(P) binding site [chemical binding]; other site 1205910006863 active site 1205910006864 enoyl-CoA hydratase; Provisional; Region: PRK08252 1205910006865 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205910006866 substrate binding site [chemical binding]; other site 1205910006867 oxyanion hole (OAH) forming residues; other site 1205910006868 trimer interface [polypeptide binding]; other site 1205910006869 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1205910006870 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 1205910006871 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1205910006872 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1205910006873 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1205910006874 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1205910006875 active site 1205910006876 classical (c) SDRs; Region: SDR_c; cd05233 1205910006877 active site 1205910006878 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1205910006879 amidase catalytic site [active] 1205910006880 Zn binding residues [ion binding]; other site 1205910006881 substrate binding site [chemical binding]; other site 1205910006882 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1205910006883 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1205910006884 Phage-related minor tail protein [Function unknown]; Region: COG5280 1205910006885 Phage-related protein [Function unknown]; Region: COG5412 1205910006886 membrane protein P6; Region: PHA01399 1205910006887 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 1205910006888 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1205910006889 Na binding site [ion binding]; other site 1205910006890 putative substrate binding site [chemical binding]; other site 1205910006891 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1205910006892 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 1205910006893 phenylhydantoinase; Validated; Region: PRK08323 1205910006894 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 1205910006895 tetramer interface [polypeptide binding]; other site 1205910006896 active site 1205910006897 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1205910006898 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 1205910006899 active site 1205910006900 catalytic triad [active] 1205910006901 dimer interface [polypeptide binding]; other site 1205910006902 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1205910006903 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1205910006904 spermidine synthase; Provisional; Region: PRK03612 1205910006905 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910006906 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1205910006907 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 1205910006908 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1205910006909 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1205910006910 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1205910006911 active site residue [active] 1205910006912 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1205910006913 active site residue [active] 1205910006914 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1205910006915 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 1205910006916 protein-splicing catalytic site; other site 1205910006917 thioester formation/cholesterol transfer; other site 1205910006918 N-acetylmuramoyl-L-alanine amidase; Region: Amidase_2; pfam01510 1205910006919 substrate binding site [chemical binding]; other site 1205910006920 amidase catalytic site [active] 1205910006921 Zn binding residues [ion binding]; other site 1205910006922 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 1205910006923 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1205910006924 putative substrate binding site [chemical binding]; other site 1205910006925 putative ATP binding site [chemical binding]; other site 1205910006926 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1205910006927 nudix motif; other site 1205910006928 Phospholipid methyltransferase; Region: PEMT; cl17370 1205910006929 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1205910006930 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1205910006931 molybdopterin cofactor binding site; other site 1205910006932 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1205910006933 molybdopterin cofactor binding site; other site 1205910006934 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1205910006935 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205910006936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910006937 active site 1205910006938 phosphorylation site [posttranslational modification] 1205910006939 intermolecular recognition site; other site 1205910006940 dimerization interface [polypeptide binding]; other site 1205910006941 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205910006942 DNA binding site [nucleotide binding] 1205910006943 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1205910006944 HAMP domain; Region: HAMP; pfam00672 1205910006945 dimerization interface [polypeptide binding]; other site 1205910006946 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1205910006947 dimer interface [polypeptide binding]; other site 1205910006948 phosphorylation site [posttranslational modification] 1205910006949 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910006950 ATP binding site [chemical binding]; other site 1205910006951 Mg2+ binding site [ion binding]; other site 1205910006952 G-X-G motif; other site 1205910006953 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1205910006954 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 1205910006955 putative ADP-binding pocket [chemical binding]; other site 1205910006956 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 1205910006957 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1205910006958 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1205910006959 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205910006960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910006961 active site 1205910006962 phosphorylation site [posttranslational modification] 1205910006963 intermolecular recognition site; other site 1205910006964 dimerization interface [polypeptide binding]; other site 1205910006965 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205910006966 DNA binding residues [nucleotide binding] 1205910006967 dimerization interface [polypeptide binding]; other site 1205910006968 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1205910006969 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1205910006970 GAF domain; Region: GAF_2; pfam13185 1205910006971 GAF domain; Region: GAF; pfam01590 1205910006972 GAF domain; Region: GAF_3; pfam13492 1205910006973 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1205910006974 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1205910006975 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1205910006976 dimerization interface [polypeptide binding]; other site 1205910006977 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1205910006978 dimerization interface [polypeptide binding]; other site 1205910006979 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1205910006980 dimerization interface [polypeptide binding]; other site 1205910006981 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1205910006982 dimerization interface [polypeptide binding]; other site 1205910006983 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1205910006984 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1205910006985 dimerization interface [polypeptide binding]; other site 1205910006986 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1205910006987 dimerization interface [polypeptide binding]; other site 1205910006988 GAF domain; Region: GAF_2; pfam13185 1205910006989 GAF domain; Region: GAF_3; pfam13492 1205910006990 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1205910006991 dimer interface [polypeptide binding]; other site 1205910006992 phosphorylation site [posttranslational modification] 1205910006993 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910006994 ATP binding site [chemical binding]; other site 1205910006995 Mg2+ binding site [ion binding]; other site 1205910006996 G-X-G motif; other site 1205910006997 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1205910006998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910006999 active site 1205910007000 phosphorylation site [posttranslational modification] 1205910007001 intermolecular recognition site; other site 1205910007002 dimerization interface [polypeptide binding]; other site 1205910007003 Response regulator receiver domain; Region: Response_reg; pfam00072 1205910007004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910007005 active site 1205910007006 phosphorylation site [posttranslational modification] 1205910007007 intermolecular recognition site; other site 1205910007008 dimerization interface [polypeptide binding]; other site 1205910007009 PAS domain; Region: PAS; smart00091 1205910007010 putative active site [active] 1205910007011 heme pocket [chemical binding]; other site 1205910007012 ANTAR domain; Region: ANTAR; pfam03861 1205910007013 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1205910007014 anti sigma factor interaction site; other site 1205910007015 regulatory phosphorylation site [posttranslational modification]; other site 1205910007016 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1205910007017 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205910007018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910007019 homodimer interface [polypeptide binding]; other site 1205910007020 catalytic residue [active] 1205910007021 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1205910007022 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1205910007023 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1205910007024 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1205910007025 active site 1205910007026 CopC domain; Region: CopC; pfam04234 1205910007027 Transcription factor WhiB; Region: Whib; pfam02467 1205910007028 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205910007029 Coenzyme A binding pocket [chemical binding]; other site 1205910007030 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 1205910007031 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1205910007032 inhibitor-cofactor binding pocket; inhibition site 1205910007033 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910007034 catalytic residue [active] 1205910007035 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 1205910007036 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 1205910007037 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1205910007038 substrate binding pocket [chemical binding]; other site 1205910007039 membrane-bound complex binding site; other site 1205910007040 hinge residues; other site 1205910007041 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1205910007042 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910007043 dimer interface [polypeptide binding]; other site 1205910007044 conserved gate region; other site 1205910007045 putative PBP binding loops; other site 1205910007046 ABC-ATPase subunit interface; other site 1205910007047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910007048 dimer interface [polypeptide binding]; other site 1205910007049 conserved gate region; other site 1205910007050 putative PBP binding loops; other site 1205910007051 ABC-ATPase subunit interface; other site 1205910007052 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1205910007053 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910007054 Walker A/P-loop; other site 1205910007055 ATP binding site [chemical binding]; other site 1205910007056 Q-loop/lid; other site 1205910007057 ABC transporter signature motif; other site 1205910007058 Walker B; other site 1205910007059 D-loop; other site 1205910007060 H-loop/switch region; other site 1205910007061 CAAX protease self-immunity; Region: Abi; pfam02517 1205910007062 polyphosphate kinase; Provisional; Region: PRK05443 1205910007063 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1205910007064 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1205910007065 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1205910007066 putative domain interface [polypeptide binding]; other site 1205910007067 putative active site [active] 1205910007068 catalytic site [active] 1205910007069 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1205910007070 putative domain interface [polypeptide binding]; other site 1205910007071 putative active site [active] 1205910007072 catalytic site [active] 1205910007073 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1205910007074 active site 1205910007075 Ap6A binding site [chemical binding]; other site 1205910007076 nudix motif; other site 1205910007077 metal binding site [ion binding]; metal-binding site 1205910007078 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 1205910007079 putative hydrophobic ligand binding site [chemical binding]; other site 1205910007080 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 1205910007081 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1205910007082 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1205910007083 anti sigma factor interaction site; other site 1205910007084 regulatory phosphorylation site [posttranslational modification]; other site 1205910007085 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1205910007086 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1205910007087 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1205910007088 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1205910007089 G5 domain; Region: G5; pfam07501 1205910007090 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1205910007091 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1205910007092 catalytic residue [active] 1205910007093 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1205910007094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910007095 S-adenosylmethionine binding site [chemical binding]; other site 1205910007096 PspC domain; Region: PspC; pfam04024 1205910007097 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1205910007098 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1205910007099 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205910007100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910007101 active site 1205910007102 phosphorylation site [posttranslational modification] 1205910007103 intermolecular recognition site; other site 1205910007104 dimerization interface [polypeptide binding]; other site 1205910007105 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205910007106 DNA binding residues [nucleotide binding] 1205910007107 dimerization interface [polypeptide binding]; other site 1205910007108 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 1205910007109 active site 1205910007110 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1205910007111 Part of AAA domain; Region: AAA_19; pfam13245 1205910007112 Family description; Region: UvrD_C_2; pfam13538 1205910007113 Peptidase family M23; Region: Peptidase_M23; pfam01551 1205910007114 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1205910007115 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1205910007116 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1205910007117 DNA binding site [nucleotide binding] 1205910007118 active site 1205910007119 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1205910007120 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1205910007121 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1205910007122 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1205910007123 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1205910007124 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1205910007125 minor groove reading motif; other site 1205910007126 helix-hairpin-helix signature motif; other site 1205910007127 substrate binding pocket [chemical binding]; other site 1205910007128 active site 1205910007129 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1205910007130 B12 binding site [chemical binding]; other site 1205910007131 cobalt ligand [ion binding]; other site 1205910007132 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1205910007133 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1205910007134 CoA-ligase; Region: Ligase_CoA; pfam00549 1205910007135 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1205910007136 CoA binding domain; Region: CoA_binding; smart00881 1205910007137 CoA-ligase; Region: Ligase_CoA; pfam00549 1205910007138 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1205910007139 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1205910007140 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1205910007141 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205910007142 ATP binding site [chemical binding]; other site 1205910007143 putative Mg++ binding site [ion binding]; other site 1205910007144 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205910007145 nucleotide binding region [chemical binding]; other site 1205910007146 ATP-binding site [chemical binding]; other site 1205910007147 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1205910007148 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1205910007149 ATP-sulfurylase; Region: ATP-sulfurylase; pfam01747 1205910007150 HIGH motif; other site 1205910007151 nucleotide binding site [chemical binding]; other site 1205910007152 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1205910007153 ligand-binding site [chemical binding]; other site 1205910007154 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12333 1205910007155 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1205910007156 homodimer interface [polypeptide binding]; other site 1205910007157 metal binding site [ion binding]; metal-binding site 1205910007158 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 1205910007159 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 1205910007160 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1205910007161 enolase; Provisional; Region: eno; PRK00077 1205910007162 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1205910007163 dimer interface [polypeptide binding]; other site 1205910007164 metal binding site [ion binding]; metal-binding site 1205910007165 substrate binding pocket [chemical binding]; other site 1205910007166 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1205910007167 Septum formation initiator; Region: DivIC; pfam04977 1205910007168 Protein of unknown function (DUF501); Region: DUF501; pfam04417 1205910007169 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1205910007170 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1205910007171 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1205910007172 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 1205910007173 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1205910007174 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 1205910007175 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 1205910007176 Glutamate binding site [chemical binding]; other site 1205910007177 NAD binding site [chemical binding]; other site 1205910007178 catalytic residues [active] 1205910007179 Proline dehydrogenase; Region: Pro_dh; cl03282 1205910007180 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1205910007181 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 1205910007182 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 1205910007183 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1205910007184 dimer interface [polypeptide binding]; other site 1205910007185 active site 1205910007186 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 1205910007187 active site 1205910007188 catalytic triad [active] 1205910007189 oxyanion hole [active] 1205910007190 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 1205910007191 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1205910007192 dimer interface [polypeptide binding]; other site 1205910007193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910007194 catalytic residue [active] 1205910007195 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1205910007196 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1205910007197 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1205910007198 trimer interface [polypeptide binding]; other site 1205910007199 active site 1205910007200 substrate binding site [chemical binding]; other site 1205910007201 CoA binding site [chemical binding]; other site 1205910007202 cystathionine gamma-synthase; Provisional; Region: PRK07811 1205910007203 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1205910007204 homodimer interface [polypeptide binding]; other site 1205910007205 substrate-cofactor binding pocket; other site 1205910007206 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910007207 catalytic residue [active] 1205910007208 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1205910007209 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205910007210 DNA-binding site [nucleotide binding]; DNA binding site 1205910007211 UTRA domain; Region: UTRA; cl17743 1205910007212 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1205910007213 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205910007214 DNA-binding site [nucleotide binding]; DNA binding site 1205910007215 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1205910007216 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 1205910007217 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 1205910007218 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1205910007219 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 1205910007220 FIST N domain; Region: FIST; pfam08495 1205910007221 FIST C domain; Region: FIST_C; pfam10442 1205910007222 RDD family; Region: RDD; pfam06271 1205910007223 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1205910007224 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1205910007225 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1205910007226 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1205910007227 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1205910007228 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910007229 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910007230 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1205910007231 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 1205910007232 putative NAD(P) binding site [chemical binding]; other site 1205910007233 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1205910007234 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1205910007235 catalytic residues [active] 1205910007236 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1205910007237 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910007238 Walker A/P-loop; other site 1205910007239 ATP binding site [chemical binding]; other site 1205910007240 Q-loop/lid; other site 1205910007241 ABC transporter signature motif; other site 1205910007242 Walker B; other site 1205910007243 D-loop; other site 1205910007244 H-loop/switch region; other site 1205910007245 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1205910007246 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1205910007247 ABC-ATPase subunit interface; other site 1205910007248 dimer interface [polypeptide binding]; other site 1205910007249 putative PBP binding regions; other site 1205910007250 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1205910007251 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1205910007252 intersubunit interface [polypeptide binding]; other site 1205910007253 PQQ-like domain; Region: PQQ_2; pfam13360 1205910007254 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205910007255 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205910007256 active site 1205910007257 ATP binding site [chemical binding]; other site 1205910007258 substrate binding site [chemical binding]; other site 1205910007259 activation loop (A-loop); other site 1205910007260 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1205910007261 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205910007262 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205910007263 DNA binding residues [nucleotide binding] 1205910007264 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1205910007265 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1205910007266 catalytic residue [active] 1205910007267 putative FPP diphosphate binding site; other site 1205910007268 putative FPP binding hydrophobic cleft; other site 1205910007269 dimer interface [polypeptide binding]; other site 1205910007270 putative IPP diphosphate binding site; other site 1205910007271 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1205910007272 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1205910007273 putative active site [active] 1205910007274 PhoH-like protein; Region: PhoH; pfam02562 1205910007275 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1205910007276 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1205910007277 catalytic residue [active] 1205910007278 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1205910007279 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1205910007280 catalytic residue [active] 1205910007281 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205910007282 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205910007283 active site 1205910007284 ATP binding site [chemical binding]; other site 1205910007285 substrate binding site [chemical binding]; other site 1205910007286 activation loop (A-loop); other site 1205910007287 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1205910007288 Class II fumarases; Region: Fumarase_classII; cd01362 1205910007289 active site 1205910007290 tetramer interface [polypeptide binding]; other site 1205910007291 RNHCP domain; Region: RNHCP; pfam12647 1205910007292 RNHCP domain; Region: RNHCP; pfam12647 1205910007293 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1205910007294 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1205910007295 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1205910007296 putative active site [active] 1205910007297 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910007298 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910007299 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1205910007300 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1205910007301 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1205910007302 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1205910007303 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1205910007304 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1205910007305 generic binding surface II; other site 1205910007306 generic binding surface I; other site 1205910007307 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1205910007308 RmuC family; Region: RmuC; pfam02646 1205910007309 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1205910007310 GTP-binding protein YchF; Reviewed; Region: PRK09601 1205910007311 YchF GTPase; Region: YchF; cd01900 1205910007312 G1 box; other site 1205910007313 GTP/Mg2+ binding site [chemical binding]; other site 1205910007314 Switch I region; other site 1205910007315 G2 box; other site 1205910007316 Switch II region; other site 1205910007317 G3 box; other site 1205910007318 G4 box; other site 1205910007319 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1205910007320 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1205910007321 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205910007322 H+ Antiporter protein; Region: 2A0121; TIGR00900 1205910007323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910007324 putative substrate translocation pore; other site 1205910007325 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1205910007326 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 1205910007327 Predicted transcriptional regulators [Transcription]; Region: COG1733 1205910007328 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1205910007329 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1205910007330 homotrimer interaction site [polypeptide binding]; other site 1205910007331 putative active site [active] 1205910007332 YhhN-like protein; Region: YhhN; pfam07947 1205910007333 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 1205910007334 TcpE family; Region: TcpE; pfam12648 1205910007335 AAA domain; Region: AAA_31; pfam13614 1205910007336 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1205910007337 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1205910007338 AAA-like domain; Region: AAA_10; pfam12846 1205910007339 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1205910007340 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1205910007341 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205910007342 active site 1205910007343 ATP binding site [chemical binding]; other site 1205910007344 substrate binding site [chemical binding]; other site 1205910007345 activation loop (A-loop); other site 1205910007346 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910007347 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910007348 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205910007349 dimerization interface [polypeptide binding]; other site 1205910007350 putative DNA binding site [nucleotide binding]; other site 1205910007351 putative Zn2+ binding site [ion binding]; other site 1205910007352 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1205910007353 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1205910007354 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 1205910007355 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1205910007356 NlpC/P60 family; Region: NLPC_P60; pfam00877 1205910007357 thymidine kinase; Provisional; Region: PRK04296 1205910007358 Ion transport protein; Region: Ion_trans; pfam00520 1205910007359 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1205910007360 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205910007361 DNA-binding site [nucleotide binding]; DNA binding site 1205910007362 Zeta toxin; Region: Zeta_toxin; pfam06414 1205910007363 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1205910007364 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 1205910007365 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1205910007366 Walker A motif; other site 1205910007367 ATP binding site [chemical binding]; other site 1205910007368 Walker B motif; other site 1205910007369 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1205910007370 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 1205910007371 NADP binding site [chemical binding]; other site 1205910007372 dimer interface [polypeptide binding]; other site 1205910007373 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1205910007374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910007375 putative substrate translocation pore; other site 1205910007376 DNA-sulfur modification-associated; Region: DndB; cl17621 1205910007377 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1205910007378 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205910007379 NAD(P) binding site [chemical binding]; other site 1205910007380 active site 1205910007381 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1205910007382 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1205910007383 inhibitor site; inhibition site 1205910007384 active site 1205910007385 dimer interface [polypeptide binding]; other site 1205910007386 catalytic residue [active] 1205910007387 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1205910007388 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1205910007389 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1205910007390 Family of unknown function (DUF695); Region: DUF695; pfam05117 1205910007391 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1205910007392 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1205910007393 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1205910007394 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205910007395 putative phosphatase; Provisional; Region: PRK11587 1205910007396 active site 1205910007397 motif I; other site 1205910007398 motif II; other site 1205910007399 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 1205910007400 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1205910007401 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1205910007402 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1205910007403 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 1205910007404 Helix-hairpin-helix motif; Region: HHH; pfam00633 1205910007405 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1205910007406 Dimer interface [polypeptide binding]; other site 1205910007407 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1205910007408 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1205910007409 metal binding site [ion binding]; metal-binding site 1205910007410 active site 1205910007411 I-site; other site 1205910007412 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1205910007413 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205910007414 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205910007415 DNA binding residues [nucleotide binding] 1205910007416 dimerization interface [polypeptide binding]; other site 1205910007417 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1205910007418 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1205910007419 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1205910007420 TQXA domain; Region: TQXA_dom; TIGR03934 1205910007421 TQXA domain; Region: TQXA_dom; TIGR03934 1205910007422 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1205910007423 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1205910007424 GatB domain; Region: GatB_Yqey; smart00845 1205910007425 PAS domain S-box; Region: sensory_box; TIGR00229 1205910007426 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1205910007427 putative active site [active] 1205910007428 heme pocket [chemical binding]; other site 1205910007429 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1205910007430 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1205910007431 metal binding site [ion binding]; metal-binding site 1205910007432 active site 1205910007433 I-site; other site 1205910007434 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1205910007435 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1205910007436 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1205910007437 PYR/PP interface [polypeptide binding]; other site 1205910007438 dimer interface [polypeptide binding]; other site 1205910007439 TPP binding site [chemical binding]; other site 1205910007440 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1205910007441 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1205910007442 TPP-binding site [chemical binding]; other site 1205910007443 dimer interface [polypeptide binding]; other site 1205910007444 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1205910007445 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1205910007446 putative valine binding site [chemical binding]; other site 1205910007447 dimer interface [polypeptide binding]; other site 1205910007448 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1205910007449 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1205910007450 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1205910007451 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1205910007452 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1205910007453 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1205910007454 ligand binding site [chemical binding]; other site 1205910007455 NAD binding site [chemical binding]; other site 1205910007456 dimerization interface [polypeptide binding]; other site 1205910007457 catalytic site [active] 1205910007458 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1205910007459 putative L-serine binding site [chemical binding]; other site 1205910007460 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1205910007461 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1205910007462 active site 1205910007463 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1205910007464 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1205910007465 active site 1205910007466 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1205910007467 tartrate dehydrogenase; Region: TTC; TIGR02089 1205910007468 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1205910007469 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1205910007470 homodimer interface [polypeptide binding]; other site 1205910007471 substrate-cofactor binding pocket; other site 1205910007472 catalytic residue [active] 1205910007473 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 1205910007474 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 1205910007475 active site 1205910007476 catalytic residues [active] 1205910007477 metal binding site [ion binding]; metal-binding site 1205910007478 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1205910007479 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910007480 putative PBP binding loops; other site 1205910007481 ABC-ATPase subunit interface; other site 1205910007482 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1205910007483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910007484 dimer interface [polypeptide binding]; other site 1205910007485 conserved gate region; other site 1205910007486 ABC-ATPase subunit interface; other site 1205910007487 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1205910007488 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1205910007489 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1205910007490 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1205910007491 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1205910007492 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1205910007493 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1205910007494 active site 1205910007495 oxyanion hole [active] 1205910007496 catalytic triad [active] 1205910007497 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1205910007498 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1205910007499 active site 1205910007500 HIGH motif; other site 1205910007501 nucleotide binding site [chemical binding]; other site 1205910007502 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1205910007503 active site 1205910007504 KMSKS motif; other site 1205910007505 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1205910007506 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1205910007507 active site 1205910007508 metal binding site [ion binding]; metal-binding site 1205910007509 Domain of unknown function (DUF4073); Region: DUF4073; pfam13285 1205910007510 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910007511 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910007512 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1205910007513 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1205910007514 FMN-binding pocket [chemical binding]; other site 1205910007515 flavin binding motif; other site 1205910007516 phosphate binding motif [ion binding]; other site 1205910007517 beta-alpha-beta structure motif; other site 1205910007518 NAD binding pocket [chemical binding]; other site 1205910007519 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1205910007520 catalytic loop [active] 1205910007521 iron binding site [ion binding]; other site 1205910007522 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1205910007523 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1205910007524 short chain dehydrogenase; Validated; Region: PRK05855 1205910007525 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1205910007526 classical (c) SDRs; Region: SDR_c; cd05233 1205910007527 NAD(P) binding site [chemical binding]; other site 1205910007528 active site 1205910007529 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1205910007530 active site 1205910007531 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1205910007532 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1205910007533 Bacterial transcriptional regulator; Region: IclR; pfam01614 1205910007534 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1205910007535 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1205910007536 substrate binding site [chemical binding]; other site 1205910007537 ligand binding site [chemical binding]; other site 1205910007538 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1205910007539 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1205910007540 substrate binding site [chemical binding]; other site 1205910007541 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1205910007542 IHF dimer interface [polypeptide binding]; other site 1205910007543 IHF - DNA interface [nucleotide binding]; other site 1205910007544 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 1205910007545 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1205910007546 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1205910007547 putative acyl-acceptor binding pocket; other site 1205910007548 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1205910007549 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1205910007550 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1205910007551 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1205910007552 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1205910007553 homodimer interface [polypeptide binding]; other site 1205910007554 substrate-cofactor binding pocket; other site 1205910007555 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910007556 catalytic residue [active] 1205910007557 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1205910007558 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1205910007559 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1205910007560 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 1205910007561 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1205910007562 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910007563 Walker A/P-loop; other site 1205910007564 ATP binding site [chemical binding]; other site 1205910007565 Q-loop/lid; other site 1205910007566 ABC transporter signature motif; other site 1205910007567 Walker B; other site 1205910007568 D-loop; other site 1205910007569 H-loop/switch region; other site 1205910007570 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 1205910007571 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1205910007572 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910007573 Walker A/P-loop; other site 1205910007574 ATP binding site [chemical binding]; other site 1205910007575 Q-loop/lid; other site 1205910007576 ABC transporter signature motif; other site 1205910007577 Walker B; other site 1205910007578 D-loop; other site 1205910007579 H-loop/switch region; other site 1205910007580 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1205910007581 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1205910007582 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1205910007583 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1205910007584 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1205910007585 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 1205910007586 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1205910007587 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1205910007588 AsnC family; Region: AsnC_trans_reg; pfam01037 1205910007589 thiamine monophosphate kinase; Provisional; Region: PRK05731 1205910007590 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1205910007591 ATP binding site [chemical binding]; other site 1205910007592 dimerization interface [polypeptide binding]; other site 1205910007593 Cellulose binding domain; Region: CBM_2; cl17741 1205910007594 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1205910007595 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1205910007596 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1205910007597 generic binding surface II; other site 1205910007598 ssDNA binding site; other site 1205910007599 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205910007600 ATP binding site [chemical binding]; other site 1205910007601 putative Mg++ binding site [ion binding]; other site 1205910007602 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1205910007603 nucleotide binding region [chemical binding]; other site 1205910007604 ATP-binding site [chemical binding]; other site 1205910007605 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1205910007606 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910007607 S-adenosylmethionine binding site [chemical binding]; other site 1205910007608 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1205910007609 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1205910007610 active site 1205910007611 (T/H)XGH motif; other site 1205910007612 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1205910007613 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1205910007614 ribonuclease III; Reviewed; Region: rnc; PRK00102 1205910007615 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1205910007616 dimerization interface [polypeptide binding]; other site 1205910007617 active site 1205910007618 metal binding site [ion binding]; metal-binding site 1205910007619 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1205910007620 dsRNA binding site [nucleotide binding]; other site 1205910007621 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1205910007622 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1205910007623 DNA binding site [nucleotide binding] 1205910007624 catalytic residue [active] 1205910007625 H2TH interface [polypeptide binding]; other site 1205910007626 putative catalytic residues [active] 1205910007627 turnover-facilitating residue; other site 1205910007628 intercalation triad [nucleotide binding]; other site 1205910007629 8OG recognition residue [nucleotide binding]; other site 1205910007630 putative reading head residues; other site 1205910007631 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1205910007632 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1205910007633 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 1205910007634 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910007635 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910007636 acylphosphatase; Provisional; Region: PRK14422 1205910007637 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1205910007638 AAA domain; Region: AAA_23; pfam13476 1205910007639 Walker A/P-loop; other site 1205910007640 ATP binding site [chemical binding]; other site 1205910007641 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1205910007642 ABC transporter signature motif; other site 1205910007643 Walker B; other site 1205910007644 D-loop; other site 1205910007645 H-loop/switch region; other site 1205910007646 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364 1205910007647 L11 interface [polypeptide binding]; other site 1205910007648 putative EF-Tu interaction site [polypeptide binding]; other site 1205910007649 putative EF-G interaction site [polypeptide binding]; other site 1205910007650 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1205910007651 Peptidase S8 family domain, uncharacterized subfamily 5; Region: Peptidases_S8_5; cd07489 1205910007652 active site 1205910007653 catalytic triad [active] 1205910007654 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 1205910007655 PA/protease or protease-like domain interface [polypeptide binding]; other site 1205910007656 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1205910007657 catalytic residues [active] 1205910007658 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 1205910007659 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1205910007660 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1205910007661 intersubunit interface [polypeptide binding]; other site 1205910007662 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1205910007663 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1205910007664 putative PBP binding regions; other site 1205910007665 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 1205910007666 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1205910007667 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1205910007668 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1205910007669 signal recognition particle protein; Provisional; Region: PRK10867 1205910007670 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1205910007671 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1205910007672 P loop; other site 1205910007673 GTP binding site [chemical binding]; other site 1205910007674 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1205910007675 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1205910007676 hypothetical protein; Provisional; Region: PRK02821 1205910007677 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1205910007678 G-X-X-G motif; other site 1205910007679 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1205910007680 RimM N-terminal domain; Region: RimM; pfam01782 1205910007681 PRC-barrel domain; Region: PRC; pfam05239 1205910007682 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1205910007683 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1205910007684 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1205910007685 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1205910007686 Catalytic site [active] 1205910007687 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1205910007688 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 1205910007689 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 1205910007690 YcaO-like family; Region: YcaO; pfam02624 1205910007691 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 1205910007692 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1205910007693 NADPH bind site [chemical binding]; other site 1205910007694 putative FMN binding site [chemical binding]; other site 1205910007695 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1205910007696 NADPH bind site [chemical binding]; other site 1205910007697 putative FMN binding site [chemical binding]; other site 1205910007698 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 1205910007699 SpaB C-terminal domain; Region: SpaB_C; pfam14028 1205910007700 SpaB C-terminal domain; Region: SpaB_C; pfam14028 1205910007701 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1205910007702 NADPH bind site [chemical binding]; other site 1205910007703 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1205910007704 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1205910007705 active site 1205910007706 NAD binding site [chemical binding]; other site 1205910007707 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 1205910007708 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1205910007709 inhibitor-cofactor binding pocket; inhibition site 1205910007710 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910007711 catalytic residue [active] 1205910007712 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1205910007713 DNA binding site [nucleotide binding] 1205910007714 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1205910007715 hypothetical protein; Reviewed; Region: PRK12497 1205910007716 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1205910007717 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1205910007718 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205910007719 Walker A motif; other site 1205910007720 ATP binding site [chemical binding]; other site 1205910007721 Walker B motif; other site 1205910007722 arginine finger; other site 1205910007723 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1205910007724 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1205910007725 DNA protecting protein DprA; Region: dprA; TIGR00732 1205910007726 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1205910007727 homotrimer interaction site [polypeptide binding]; other site 1205910007728 putative active site [active] 1205910007729 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1205910007730 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1205910007731 active site 1205910007732 DNA binding site [nucleotide binding] 1205910007733 Int/Topo IB signature motif; other site 1205910007734 Peptidase family M23; Region: Peptidase_M23; pfam01551 1205910007735 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1205910007736 rRNA interaction site [nucleotide binding]; other site 1205910007737 S8 interaction site; other site 1205910007738 putative laminin-1 binding site; other site 1205910007739 elongation factor Ts; Provisional; Region: tsf; PRK09377 1205910007740 UBA/TS-N domain; Region: UBA; pfam00627 1205910007741 Elongation factor TS; Region: EF_TS; pfam00889 1205910007742 Elongation factor TS; Region: EF_TS; pfam00889 1205910007743 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1205910007744 putative nucleotide binding site [chemical binding]; other site 1205910007745 uridine monophosphate binding site [chemical binding]; other site 1205910007746 homohexameric interface [polypeptide binding]; other site 1205910007747 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1205910007748 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1205910007749 hinge region; other site 1205910007750 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1205910007751 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1205910007752 aminotransferase; Validated; Region: PRK07777 1205910007753 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205910007754 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910007755 homodimer interface [polypeptide binding]; other site 1205910007756 catalytic residue [active] 1205910007757 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1205910007758 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1205910007759 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1205910007760 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910007761 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1205910007762 glycogen branching enzyme; Provisional; Region: PRK05402 1205910007763 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1205910007764 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1205910007765 active site 1205910007766 catalytic site [active] 1205910007767 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1205910007768 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1205910007769 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1205910007770 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1205910007771 active site 1205910007772 catalytic site [active] 1205910007773 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1205910007774 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1205910007775 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1205910007776 active site 1205910007777 homodimer interface [polypeptide binding]; other site 1205910007778 catalytic site [active] 1205910007779 acceptor binding site [chemical binding]; other site 1205910007780 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1205910007781 Transglycosylase; Region: Transgly; pfam00912 1205910007782 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1205910007783 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 1205910007784 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1205910007785 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1205910007786 Walker A/P-loop; other site 1205910007787 ATP binding site [chemical binding]; other site 1205910007788 Q-loop/lid; other site 1205910007789 ABC transporter signature motif; other site 1205910007790 Walker B; other site 1205910007791 D-loop; other site 1205910007792 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1205910007793 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1205910007794 Walker A/P-loop; other site 1205910007795 ATP binding site [chemical binding]; other site 1205910007796 Q-loop/lid; other site 1205910007797 ABC transporter signature motif; other site 1205910007798 Walker B; other site 1205910007799 D-loop; other site 1205910007800 H-loop/switch region; other site 1205910007801 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1205910007802 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 1205910007803 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205910007804 substrate binding site [chemical binding]; other site 1205910007805 oxyanion hole (OAH) forming residues; other site 1205910007806 trimer interface [polypeptide binding]; other site 1205910007807 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205910007808 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205910007809 active site 1205910007810 ATP binding site [chemical binding]; other site 1205910007811 substrate binding site [chemical binding]; other site 1205910007812 activation loop (A-loop); other site 1205910007813 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1205910007814 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1205910007815 Ligand binding site [chemical binding]; other site 1205910007816 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1205910007817 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1205910007818 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1205910007819 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1205910007820 LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: LigD_Pol_like; cd04861 1205910007821 nucleotide binding site [chemical binding]; other site 1205910007822 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1205910007823 Domain of unknown function DUF21; Region: DUF21; pfam01595 1205910007824 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1205910007825 Transporter associated domain; Region: CorC_HlyC; smart01091 1205910007826 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1205910007827 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1205910007828 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1205910007829 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910007830 S-adenosylmethionine binding site [chemical binding]; other site 1205910007831 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 1205910007832 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1205910007833 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1205910007834 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1205910007835 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1205910007836 FAD binding domain; Region: FAD_binding_4; pfam01565 1205910007837 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1205910007838 short chain dehydrogenase; Validated; Region: PRK08264 1205910007839 classical (c) SDRs; Region: SDR_c; cd05233 1205910007840 NAD(P) binding site [chemical binding]; other site 1205910007841 active site 1205910007842 MFS/sugar transport protein; Region: MFS_2; pfam13347 1205910007843 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1205910007844 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1205910007845 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1205910007846 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1205910007847 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1205910007848 G1 box; other site 1205910007849 GTP/Mg2+ binding site [chemical binding]; other site 1205910007850 G2 box; other site 1205910007851 Switch I region; other site 1205910007852 G3 box; other site 1205910007853 Switch II region; other site 1205910007854 G4 box; other site 1205910007855 G5 box; other site 1205910007856 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1205910007857 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 1205910007858 Nitrate and nitrite sensing; Region: NIT; pfam08376 1205910007859 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1205910007860 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910007861 ATP binding site [chemical binding]; other site 1205910007862 Mg2+ binding site [ion binding]; other site 1205910007863 G-X-G motif; other site 1205910007864 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1205910007865 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910007866 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910007867 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1205910007868 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1205910007869 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910007870 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1205910007871 Walker A/P-loop; other site 1205910007872 ATP binding site [chemical binding]; other site 1205910007873 Q-loop/lid; other site 1205910007874 ABC transporter signature motif; other site 1205910007875 Walker B; other site 1205910007876 D-loop; other site 1205910007877 H-loop/switch region; other site 1205910007878 Peptidase family M23; Region: Peptidase_M23; pfam01551 1205910007879 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1205910007880 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1205910007881 Active_site [active] 1205910007882 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1205910007883 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1205910007884 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1205910007885 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1205910007886 active site 1205910007887 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1205910007888 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1205910007889 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1205910007890 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1205910007891 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 1205910007892 metal binding site [ion binding]; metal-binding site 1205910007893 putative dimer interface [polypeptide binding]; other site 1205910007894 Peptidase family M48; Region: Peptidase_M48; pfam01435 1205910007895 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1205910007896 elongation factor G; Reviewed; Region: PRK12740 1205910007897 G1 box; other site 1205910007898 putative GEF interaction site [polypeptide binding]; other site 1205910007899 GTP/Mg2+ binding site [chemical binding]; other site 1205910007900 Switch I region; other site 1205910007901 G2 box; other site 1205910007902 G3 box; other site 1205910007903 Switch II region; other site 1205910007904 G4 box; other site 1205910007905 G5 box; other site 1205910007906 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1205910007907 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1205910007908 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1205910007909 CAAX protease self-immunity; Region: Abi; pfam02517 1205910007910 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1205910007911 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1205910007912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910007913 putative substrate translocation pore; other site 1205910007914 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1205910007915 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1205910007916 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1205910007917 active site 1205910007918 catalytic residues [active] 1205910007919 metal binding site [ion binding]; metal-binding site 1205910007920 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1205910007921 active site 1205910007922 NTP binding site [chemical binding]; other site 1205910007923 metal binding triad [ion binding]; metal-binding site 1205910007924 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 1205910007925 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1205910007926 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1205910007927 active site 1205910007928 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 1205910007929 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205910007930 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910007931 active site 1205910007932 phosphorylation site [posttranslational modification] 1205910007933 intermolecular recognition site; other site 1205910007934 dimerization interface [polypeptide binding]; other site 1205910007935 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205910007936 DNA binding site [nucleotide binding] 1205910007937 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1205910007938 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1205910007939 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1205910007940 Ligand Binding Site [chemical binding]; other site 1205910007941 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1205910007942 dimer interface [polypeptide binding]; other site 1205910007943 phosphorylation site [posttranslational modification] 1205910007944 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910007945 ATP binding site [chemical binding]; other site 1205910007946 G-X-G motif; other site 1205910007947 Cytochrome P450; Region: p450; cl12078 1205910007948 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1205910007949 FAD binding domain; Region: FAD_binding_4; pfam01565 1205910007950 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910007951 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910007952 glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369 1205910007953 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1205910007954 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1205910007955 ATP binding site [chemical binding]; other site 1205910007956 Mg2+ binding site [ion binding]; other site 1205910007957 G-X-G motif; other site 1205910007958 bile acid transporter; Region: bass; TIGR00841 1205910007959 Sodium Bile acid symporter family; Region: SBF; cl17470 1205910007960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910007961 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205910007962 active site 1205910007963 phosphorylation site [posttranslational modification] 1205910007964 intermolecular recognition site; other site 1205910007965 dimerization interface [polypeptide binding]; other site 1205910007966 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205910007967 DNA binding residues [nucleotide binding] 1205910007968 Putative sensor; Region: Sensor; pfam13796 1205910007969 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1205910007970 Histidine kinase; Region: HisKA_3; pfam07730 1205910007971 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910007972 ATP binding site [chemical binding]; other site 1205910007973 Mg2+ binding site [ion binding]; other site 1205910007974 G-X-G motif; other site 1205910007975 Tubby C 2; Region: Tub_2; cl02043 1205910007976 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1205910007977 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1205910007978 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1205910007979 putative dimerization interface [polypeptide binding]; other site 1205910007980 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1205910007981 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1205910007982 active site 1205910007983 catalytic site [active] 1205910007984 substrate binding site [chemical binding]; other site 1205910007985 Response regulator receiver domain; Region: Response_reg; pfam00072 1205910007986 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910007987 active site 1205910007988 phosphorylation site [posttranslational modification] 1205910007989 intermolecular recognition site; other site 1205910007990 dimerization interface [polypeptide binding]; other site 1205910007991 tRNA binding surface [nucleotide binding]; other site 1205910007992 DALR anticodon binding domain; Region: DALR_1; smart00836 1205910007993 anticodon binding site; other site 1205910007994 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1205910007995 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1205910007996 active site 1205910007997 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1205910007998 substrate binding site [chemical binding]; other site 1205910007999 catalytic residues [active] 1205910008000 dimer interface [polypeptide binding]; other site 1205910008001 homoserine dehydrogenase; Provisional; Region: PRK06349 1205910008002 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1205910008003 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1205910008004 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1205910008005 threonine synthase; Reviewed; Region: PRK06721 1205910008006 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1205910008007 homodimer interface [polypeptide binding]; other site 1205910008008 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910008009 catalytic residue [active] 1205910008010 homoserine kinase; Provisional; Region: PRK01212 1205910008011 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1205910008012 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1205910008013 transcription termination factor Rho; Provisional; Region: PRK12608 1205910008014 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1205910008015 RNA binding site [nucleotide binding]; other site 1205910008016 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1205910008017 multimer interface [polypeptide binding]; other site 1205910008018 Walker A motif; other site 1205910008019 ATP binding site [chemical binding]; other site 1205910008020 Walker B motif; other site 1205910008021 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1205910008022 L-lactate permease; Region: Lactate_perm; cl00701 1205910008023 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1205910008024 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1205910008025 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1205910008026 RF-1 domain; Region: RF-1; pfam00472 1205910008027 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1205910008028 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910008029 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1205910008030 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1205910008031 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1205910008032 Mg++ binding site [ion binding]; other site 1205910008033 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 1205910008034 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1205910008035 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1205910008036 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1205910008037 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1205910008038 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1205910008039 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1205910008040 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1205910008041 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1205910008042 beta subunit interaction interface [polypeptide binding]; other site 1205910008043 Walker A motif; other site 1205910008044 ATP binding site [chemical binding]; other site 1205910008045 Walker B motif; other site 1205910008046 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1205910008047 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1205910008048 core domain interface [polypeptide binding]; other site 1205910008049 delta subunit interface [polypeptide binding]; other site 1205910008050 epsilon subunit interface [polypeptide binding]; other site 1205910008051 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1205910008052 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1205910008053 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1205910008054 alpha subunit interaction interface [polypeptide binding]; other site 1205910008055 Walker A motif; other site 1205910008056 ATP binding site [chemical binding]; other site 1205910008057 Walker B motif; other site 1205910008058 inhibitor binding site; inhibition site 1205910008059 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1205910008060 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1205910008061 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1205910008062 gamma subunit interface [polypeptide binding]; other site 1205910008063 epsilon subunit interface [polypeptide binding]; other site 1205910008064 LBP interface [polypeptide binding]; other site 1205910008065 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1205910008066 Domain of unknown function DUF77; Region: DUF77; pfam01910 1205910008067 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 1205910008068 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1205910008069 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 1205910008070 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 1205910008071 PA/protease or protease-like domain interface [polypeptide binding]; other site 1205910008072 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1205910008073 Peptidase family M28; Region: Peptidase_M28; pfam04389 1205910008074 active site 1205910008075 metal binding site [ion binding]; metal-binding site 1205910008076 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1205910008077 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1205910008078 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205910008079 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910008080 active site 1205910008081 phosphorylation site [posttranslational modification] 1205910008082 intermolecular recognition site; other site 1205910008083 dimerization interface [polypeptide binding]; other site 1205910008084 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205910008085 DNA binding residues [nucleotide binding] 1205910008086 dimerization interface [polypeptide binding]; other site 1205910008087 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1205910008088 Histidine kinase; Region: HisKA_3; pfam07730 1205910008089 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910008090 ATP binding site [chemical binding]; other site 1205910008091 Mg2+ binding site [ion binding]; other site 1205910008092 G-X-G motif; other site 1205910008093 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1205910008094 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1205910008095 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1205910008096 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1205910008097 Walker A/P-loop; other site 1205910008098 ATP binding site [chemical binding]; other site 1205910008099 Q-loop/lid; other site 1205910008100 ABC transporter signature motif; other site 1205910008101 Walker B; other site 1205910008102 D-loop; other site 1205910008103 H-loop/switch region; other site 1205910008104 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 1205910008105 hypothetical protein; Provisional; Region: PRK03298 1205910008106 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910008107 putative substrate translocation pore; other site 1205910008108 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1205910008109 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1205910008110 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1205910008111 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1205910008112 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1205910008113 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1205910008114 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205910008115 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1205910008116 dimer interface [polypeptide binding]; other site 1205910008117 substrate binding site [chemical binding]; other site 1205910008118 metal binding site [ion binding]; metal-binding site 1205910008119 putative acyltransferase; Provisional; Region: PRK05790 1205910008120 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1205910008121 dimer interface [polypeptide binding]; other site 1205910008122 active site 1205910008123 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 1205910008124 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1205910008125 Walker A; other site 1205910008126 Cellulose binding domain; Region: CBM_2; pfam00553 1205910008127 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1205910008128 Glyco_18 domain; Region: Glyco_18; smart00636 1205910008129 active site 1205910008130 Cellulose binding domain; Region: CBM_2; pfam00553 1205910008131 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1205910008132 Interdomain contacts; other site 1205910008133 Cytokine receptor motif; other site 1205910008134 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1205910008135 Glyco_18 domain; Region: Glyco_18; smart00636 1205910008136 active site 1205910008137 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1205910008138 MarR family; Region: MarR; pfam01047 1205910008139 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 1205910008140 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1205910008141 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1205910008142 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1205910008143 TPR motif; other site 1205910008144 binding surface 1205910008145 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 1205910008146 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1205910008147 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1205910008148 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1205910008149 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1205910008150 putative NAD(P) binding site [chemical binding]; other site 1205910008151 hypothetical protein; Validated; Region: PRK00228 1205910008152 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1205910008153 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 1205910008154 active site 1205910008155 catalytic site [active] 1205910008156 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1205910008157 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205910008158 ATP binding site [chemical binding]; other site 1205910008159 putative Mg++ binding site [ion binding]; other site 1205910008160 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 1205910008161 active site 1205910008162 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1205910008163 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1205910008164 active site 1205910008165 HIGH motif; other site 1205910008166 dimer interface [polypeptide binding]; other site 1205910008167 KMSKS motif; other site 1205910008168 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205910008169 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1205910008170 Isochorismatase family; Region: Isochorismatase; pfam00857 1205910008171 catalytic triad [active] 1205910008172 metal binding site [ion binding]; metal-binding site 1205910008173 conserved cis-peptide bond; other site 1205910008174 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1205910008175 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1205910008176 active site 1205910008177 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 1205910008178 MPN+ (JAMM) motif; other site 1205910008179 Zinc-binding site [ion binding]; other site 1205910008180 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1205910008181 MoaE interaction surface [polypeptide binding]; other site 1205910008182 MoeB interaction surface [polypeptide binding]; other site 1205910008183 thiocarboxylated glycine; other site 1205910008184 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1205910008185 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1205910008186 dimer interface [polypeptide binding]; other site 1205910008187 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910008188 catalytic residue [active] 1205910008189 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1205910008190 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1205910008191 ribonuclease PH; Reviewed; Region: rph; PRK00173 1205910008192 hexamer interface [polypeptide binding]; other site 1205910008193 active site 1205910008194 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1205910008195 active site 1205910008196 dimerization interface [polypeptide binding]; other site 1205910008197 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1205910008198 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1205910008199 Transglycosylase; Region: Transgly; pfam00912 1205910008200 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1205910008201 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1205910008202 Prenyltransferase-like; Region: Prenyltrans_1; pfam13243 1205910008203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910008204 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1205910008205 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1205910008206 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1205910008207 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1205910008208 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910008209 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910008210 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1205910008211 quinolinate synthetase; Provisional; Region: PRK09375 1205910008212 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1205910008213 nudix motif; other site 1205910008214 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1205910008215 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205910008216 motif II; other site 1205910008217 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1205910008218 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1205910008219 Walker A/P-loop; other site 1205910008220 ATP binding site [chemical binding]; other site 1205910008221 Q-loop/lid; other site 1205910008222 ABC transporter signature motif; other site 1205910008223 Walker B; other site 1205910008224 D-loop; other site 1205910008225 H-loop/switch region; other site 1205910008226 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1205910008227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910008228 conserved gate region; other site 1205910008229 ABC-ATPase subunit interface; other site 1205910008230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1205910008231 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1205910008232 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1205910008233 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1205910008234 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1205910008235 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1205910008236 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1205910008237 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1205910008238 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205910008239 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205910008240 active site 1205910008241 ATP binding site [chemical binding]; other site 1205910008242 substrate binding site [chemical binding]; other site 1205910008243 activation loop (A-loop); other site 1205910008244 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1205910008245 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1205910008246 catalytic triad [active] 1205910008247 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1205910008248 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1205910008249 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1205910008250 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1205910008251 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1205910008252 catalytic residue [active] 1205910008253 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1205910008254 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1205910008255 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1205910008256 putative active site [active] 1205910008257 putative substrate binding site [chemical binding]; other site 1205910008258 putative cosubstrate binding site; other site 1205910008259 catalytic site [active] 1205910008260 Asp23 family; Region: Asp23; pfam03780 1205910008261 Asp23 family; Region: Asp23; cl00574 1205910008262 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1205910008263 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1205910008264 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1205910008265 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1205910008266 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1205910008267 dimer interface [polypeptide binding]; other site 1205910008268 active site 1205910008269 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1205910008270 folate binding site [chemical binding]; other site 1205910008271 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1205910008272 lipoyl attachment site [posttranslational modification]; other site 1205910008273 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 1205910008274 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1205910008275 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1205910008276 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 1205910008277 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1205910008278 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1205910008279 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1205910008280 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1205910008281 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1205910008282 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1205910008283 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1205910008284 active site 1205910008285 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 1205910008286 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 1205910008287 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1205910008288 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1205910008289 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1205910008290 active site 1205910008291 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1205910008292 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1205910008293 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1205910008294 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205910008295 acyl-activating enzyme (AAE) consensus motif; other site 1205910008296 AMP binding site [chemical binding]; other site 1205910008297 active site 1205910008298 CoA binding site [chemical binding]; other site 1205910008299 Short C-terminal domain; Region: SHOCT; pfam09851 1205910008300 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1205910008301 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1205910008302 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1205910008303 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1205910008304 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205910008305 L-asparaginase II; Region: Asparaginase_II; pfam06089 1205910008306 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1205910008307 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1205910008308 active site 1205910008309 catalytic site [active] 1205910008310 substrate binding site [chemical binding]; other site 1205910008311 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910008312 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910008313 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1205910008314 heme binding pocket [chemical binding]; other site 1205910008315 heme ligand [chemical binding]; other site 1205910008316 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1205910008317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910008318 active site 1205910008319 phosphorylation site [posttranslational modification] 1205910008320 intermolecular recognition site; other site 1205910008321 dimerization interface [polypeptide binding]; other site 1205910008322 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1205910008323 CHASE3 domain; Region: CHASE3; pfam05227 1205910008324 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1205910008325 dimerization interface [polypeptide binding]; other site 1205910008326 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1205910008327 dimer interface [polypeptide binding]; other site 1205910008328 phosphorylation site [posttranslational modification] 1205910008329 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910008330 ATP binding site [chemical binding]; other site 1205910008331 Mg2+ binding site [ion binding]; other site 1205910008332 G-X-G motif; other site 1205910008333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910008334 Response regulator receiver domain; Region: Response_reg; pfam00072 1205910008335 active site 1205910008336 phosphorylation site [posttranslational modification] 1205910008337 intermolecular recognition site; other site 1205910008338 dimerization interface [polypeptide binding]; other site 1205910008339 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1205910008340 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1205910008341 active site 1205910008342 Fructosamine kinase; Region: Fructosamin_kin; cl17579 1205910008343 Phosphotransferase enzyme family; Region: APH; pfam01636 1205910008344 putative oxidoreductase; Provisional; Region: PRK11579 1205910008345 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1205910008346 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1205910008347 Predicted transcriptional regulators [Transcription]; Region: COG1733 1205910008348 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1205910008349 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1205910008350 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1205910008351 NAD binding site [chemical binding]; other site 1205910008352 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1205910008353 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205910008354 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1205910008355 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1205910008356 short chain dehydrogenase; Provisional; Region: PRK06181 1205910008357 classical (c) SDRs; Region: SDR_c; cd05233 1205910008358 NAD(P) binding site [chemical binding]; other site 1205910008359 active site 1205910008360 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1205910008361 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1205910008362 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1205910008363 DNA binding residues [nucleotide binding] 1205910008364 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1205910008365 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1205910008366 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 1205910008367 IncA protein; Region: IncA; pfam04156 1205910008368 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1205910008369 Part of AAA domain; Region: AAA_19; pfam13245 1205910008370 Family description; Region: UvrD_C_2; pfam13538 1205910008371 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1205910008372 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1205910008373 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1205910008374 putative active site [active] 1205910008375 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1205910008376 putative active site [active] 1205910008377 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1205910008378 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1205910008379 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1205910008380 putative active site [active] 1205910008381 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1205910008382 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1205910008383 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1205910008384 putative active site [active] 1205910008385 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1205910008386 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1205910008387 Septum formation; Region: Septum_form; pfam13845 1205910008388 TAP-like protein; Region: Abhydrolase_4; pfam08386 1205910008389 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1205910008390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910008391 dimer interface [polypeptide binding]; other site 1205910008392 conserved gate region; other site 1205910008393 putative PBP binding loops; other site 1205910008394 ABC-ATPase subunit interface; other site 1205910008395 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1205910008396 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910008397 dimer interface [polypeptide binding]; other site 1205910008398 conserved gate region; other site 1205910008399 putative PBP binding loops; other site 1205910008400 ABC-ATPase subunit interface; other site 1205910008401 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1205910008402 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1205910008403 Walker A/P-loop; other site 1205910008404 ATP binding site [chemical binding]; other site 1205910008405 Q-loop/lid; other site 1205910008406 ABC transporter signature motif; other site 1205910008407 Walker B; other site 1205910008408 D-loop; other site 1205910008409 H-loop/switch region; other site 1205910008410 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1205910008411 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1205910008412 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1205910008413 Walker A/P-loop; other site 1205910008414 ATP binding site [chemical binding]; other site 1205910008415 Q-loop/lid; other site 1205910008416 ABC transporter signature motif; other site 1205910008417 Walker B; other site 1205910008418 D-loop; other site 1205910008419 H-loop/switch region; other site 1205910008420 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1205910008421 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 1205910008422 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1205910008423 substrate binding site [chemical binding]; other site 1205910008424 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1205910008425 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 1205910008426 NAD(P) binding site [chemical binding]; other site 1205910008427 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1205910008428 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910008429 ATP binding site [chemical binding]; other site 1205910008430 Mg2+ binding site [ion binding]; other site 1205910008431 G-X-G motif; other site 1205910008432 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 1205910008433 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1205910008434 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1205910008435 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1205910008436 G1 box; other site 1205910008437 GTP/Mg2+ binding site [chemical binding]; other site 1205910008438 G2 box; other site 1205910008439 Switch I region; other site 1205910008440 G3 box; other site 1205910008441 Switch II region; other site 1205910008442 G4 box; other site 1205910008443 G5 box; other site 1205910008444 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1205910008445 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205910008446 active site 1205910008447 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205910008448 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1205910008449 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1205910008450 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1205910008451 Enoylreductase; Region: PKS_ER; smart00829 1205910008452 NAD(P) binding site [chemical binding]; other site 1205910008453 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1205910008454 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1205910008455 putative NADP binding site [chemical binding]; other site 1205910008456 active site 1205910008457 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205910008458 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205910008459 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1205910008460 active site 1205910008461 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1205910008462 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205910008463 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205910008464 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1205910008465 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205910008466 active site 1205910008467 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205910008468 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1205910008469 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1205910008470 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1205910008471 putative NADP binding site [chemical binding]; other site 1205910008472 active site 1205910008473 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205910008474 Thioesterase; Region: PKS_TE; smart00824 1205910008475 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1205910008476 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205910008477 ATP binding site [chemical binding]; other site 1205910008478 putative Mg++ binding site [ion binding]; other site 1205910008479 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205910008480 nucleotide binding region [chemical binding]; other site 1205910008481 ATP-binding site [chemical binding]; other site 1205910008482 Helicase associated domain (HA2); Region: HA2; pfam04408 1205910008483 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1205910008484 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1205910008485 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1205910008486 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1205910008487 heme-binding site [chemical binding]; other site 1205910008488 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205910008489 NAD(P) binding site [chemical binding]; other site 1205910008490 active site 1205910008491 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1205910008492 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205910008493 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1205910008494 DNA-binding site [nucleotide binding]; DNA binding site 1205910008495 FCD domain; Region: FCD; pfam07729 1205910008496 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1205910008497 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1205910008498 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1205910008499 putative active site [active] 1205910008500 catalytic triad [active] 1205910008501 putative dimer interface [polypeptide binding]; other site 1205910008502 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1205910008503 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1205910008504 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1205910008505 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1205910008506 hypothetical protein; Validated; Region: PRK06201 1205910008507 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 1205910008508 BioY family; Region: BioY; pfam02632 1205910008509 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1205910008510 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1205910008511 Walker A/P-loop; other site 1205910008512 ATP binding site [chemical binding]; other site 1205910008513 Q-loop/lid; other site 1205910008514 ABC transporter signature motif; other site 1205910008515 Walker B; other site 1205910008516 D-loop; other site 1205910008517 H-loop/switch region; other site 1205910008518 Cobalt transport protein; Region: CbiQ; cl00463 1205910008519 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1205910008520 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1205910008521 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205910008522 NAD(P) binding site [chemical binding]; other site 1205910008523 active site 1205910008524 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910008525 non-specific DNA binding site [nucleotide binding]; other site 1205910008526 salt bridge; other site 1205910008527 sequence-specific DNA binding site [nucleotide binding]; other site 1205910008528 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1205910008529 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1205910008530 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1205910008531 intersubunit interface [polypeptide binding]; other site 1205910008532 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1205910008533 TrkA-N domain; Region: TrkA_N; pfam02254 1205910008534 TrkA-C domain; Region: TrkA_C; pfam02080 1205910008535 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1205910008536 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1205910008537 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1205910008538 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205910008539 dimerization interface [polypeptide binding]; other site 1205910008540 putative DNA binding site [nucleotide binding]; other site 1205910008541 putative Zn2+ binding site [ion binding]; other site 1205910008542 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1205910008543 Protein export membrane protein; Region: SecD_SecF; cl14618 1205910008544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910008545 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1205910008546 putative substrate translocation pore; other site 1205910008547 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1205910008548 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 1205910008549 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1205910008550 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1205910008551 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910008552 dimer interface [polypeptide binding]; other site 1205910008553 ABC-ATPase subunit interface; other site 1205910008554 putative PBP binding loops; other site 1205910008555 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1205910008556 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910008557 dimer interface [polypeptide binding]; other site 1205910008558 conserved gate region; other site 1205910008559 putative PBP binding loops; other site 1205910008560 ABC-ATPase subunit interface; other site 1205910008561 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1205910008562 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1205910008563 Walker A/P-loop; other site 1205910008564 ATP binding site [chemical binding]; other site 1205910008565 Q-loop/lid; other site 1205910008566 ABC transporter signature motif; other site 1205910008567 Walker B; other site 1205910008568 D-loop; other site 1205910008569 H-loop/switch region; other site 1205910008570 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1205910008571 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1205910008572 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1205910008573 Walker A/P-loop; other site 1205910008574 ATP binding site [chemical binding]; other site 1205910008575 Q-loop/lid; other site 1205910008576 ABC transporter signature motif; other site 1205910008577 Walker B; other site 1205910008578 D-loop; other site 1205910008579 H-loop/switch region; other site 1205910008580 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1205910008581 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1205910008582 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1205910008583 Amb_all domain; Region: Amb_all; smart00656 1205910008584 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1205910008585 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 1205910008586 putative ADP-binding pocket [chemical binding]; other site 1205910008587 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1205910008588 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1205910008589 ligand binding site [chemical binding]; other site 1205910008590 TIGR04222 domain; Region: near_uncomplex 1205910008591 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1205910008592 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205910008593 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 1205910008594 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1205910008595 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205910008596 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205910008597 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1205910008598 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205910008599 dimerization interface [polypeptide binding]; other site 1205910008600 putative DNA binding site [nucleotide binding]; other site 1205910008601 putative Zn2+ binding site [ion binding]; other site 1205910008602 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205910008603 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205910008604 active site 1205910008605 ATP binding site [chemical binding]; other site 1205910008606 substrate binding site [chemical binding]; other site 1205910008607 activation loop (A-loop); other site 1205910008608 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1205910008609 active site 1205910008610 ATP binding site [chemical binding]; other site 1205910008611 substrate binding site [chemical binding]; other site 1205910008612 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1205910008613 substrate binding site [chemical binding]; other site 1205910008614 activation loop (A-loop); other site 1205910008615 activation loop (A-loop); other site 1205910008616 Predicted membrane protein [Function unknown]; Region: COG2311 1205910008617 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1205910008618 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 1205910008619 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1205910008620 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1205910008621 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1205910008622 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1205910008623 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1205910008624 ATP binding site [chemical binding]; other site 1205910008625 Walker A motif; other site 1205910008626 hexamer interface [polypeptide binding]; other site 1205910008627 Walker B motif; other site 1205910008628 TadE-like protein; Region: TadE; pfam07811 1205910008629 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205910008630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1205910008631 active site 1205910008632 phosphorylation site [posttranslational modification] 1205910008633 intermolecular recognition site; other site 1205910008634 dimerization interface [polypeptide binding]; other site 1205910008635 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1205910008636 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1205910008637 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1205910008638 Uncharacterized conserved protein [Function unknown]; Region: COG3339 1205910008639 enterobactin receptor protein; Provisional; Region: PRK13483 1205910008640 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1205910008641 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1205910008642 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1205910008643 non-specific DNA interactions [nucleotide binding]; other site 1205910008644 DNA binding site [nucleotide binding] 1205910008645 sequence specific DNA binding site [nucleotide binding]; other site 1205910008646 putative cAMP binding site [chemical binding]; other site 1205910008647 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1205910008648 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1205910008649 nucleotide binding site [chemical binding]; other site 1205910008650 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1205910008651 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1205910008652 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 1205910008653 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1205910008654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910008655 ABC-ATPase subunit interface; other site 1205910008656 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1205910008657 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910008658 dimer interface [polypeptide binding]; other site 1205910008659 conserved gate region; other site 1205910008660 putative PBP binding loops; other site 1205910008661 ABC-ATPase subunit interface; other site 1205910008662 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 1205910008663 active site 1205910008664 catalytic site [active] 1205910008665 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1205910008666 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 1205910008667 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1205910008668 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205910008669 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205910008670 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1205910008671 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1205910008672 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205910008673 DNA-binding site [nucleotide binding]; DNA binding site 1205910008674 FCD domain; Region: FCD; pfam07729 1205910008675 metabolite-proton symporter; Region: 2A0106; TIGR00883 1205910008676 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910008677 putative substrate translocation pore; other site 1205910008678 ornithine cyclodeaminase; Validated; Region: PRK06141 1205910008679 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1205910008680 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1205910008681 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1205910008682 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 1205910008683 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1205910008684 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1205910008685 dimerization interface [polypeptide binding]; other site 1205910008686 TIR domain; Region: TIR_2; pfam13676 1205910008687 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910008688 non-specific DNA binding site [nucleotide binding]; other site 1205910008689 salt bridge; other site 1205910008690 sequence-specific DNA binding site [nucleotide binding]; other site 1205910008691 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910008692 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1205910008693 putative substrate translocation pore; other site 1205910008694 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910008695 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910008696 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1205910008697 beta-galactosidase; Region: BGL; TIGR03356 1205910008698 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1205910008699 catalytic site [active] 1205910008700 putative active site [active] 1205910008701 putative substrate binding site [chemical binding]; other site 1205910008702 dimer interface [polypeptide binding]; other site 1205910008703 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1205910008704 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1205910008705 metal ion-dependent adhesion site (MIDAS); other site 1205910008706 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1205910008707 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1205910008708 metal ion-dependent adhesion site (MIDAS); other site 1205910008709 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1205910008710 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1205910008711 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 1205910008712 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1205910008713 putative ligand binding site [chemical binding]; other site 1205910008714 putative NAD binding site [chemical binding]; other site 1205910008715 catalytic site [active] 1205910008716 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 1205910008717 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 1205910008718 active site 1205910008719 DNA binding site [nucleotide binding] 1205910008720 catalytic site [active] 1205910008721 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1205910008722 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1205910008723 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1205910008724 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1205910008725 active site 1205910008726 catalytic site [active] 1205910008727 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1205910008728 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1205910008729 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1205910008730 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1205910008731 catalytic residue [active] 1205910008732 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 1205910008733 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 1205910008734 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1205910008735 active site 1205910008736 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1205910008737 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 1205910008738 putative ADP-binding pocket [chemical binding]; other site 1205910008739 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1205910008740 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1205910008741 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1205910008742 putative dimerization interface [polypeptide binding]; other site 1205910008743 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1205910008744 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205910008745 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910008746 homodimer interface [polypeptide binding]; other site 1205910008747 catalytic residue [active] 1205910008748 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1205910008749 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1205910008750 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1205910008751 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1205910008752 dimer interface [polypeptide binding]; other site 1205910008753 substrate binding site [chemical binding]; other site 1205910008754 ATP binding site [chemical binding]; other site 1205910008755 Domain of unknown function (DUF368); Region: DUF368; pfam04018 1205910008756 acyl-CoA synthetase; Validated; Region: PRK07798 1205910008757 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205910008758 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 1205910008759 acyl-activating enzyme (AAE) consensus motif; other site 1205910008760 acyl-activating enzyme (AAE) consensus motif; other site 1205910008761 putative AMP binding site [chemical binding]; other site 1205910008762 putative active site [active] 1205910008763 putative CoA binding site [chemical binding]; other site 1205910008764 ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885 1205910008765 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1205910008766 inhibitor-cofactor binding pocket; inhibition site 1205910008767 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910008768 catalytic residue [active] 1205910008769 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1205910008770 active site 1205910008771 oxyanion hole [active] 1205910008772 catalytic triad [active] 1205910008773 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 1205910008774 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205910008775 NAD(P) binding site [chemical binding]; other site 1205910008776 active site 1205910008777 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1205910008778 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1205910008779 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1205910008780 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1205910008781 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1205910008782 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1205910008783 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1205910008784 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1205910008785 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1205910008786 active site 1205910008787 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1205910008788 putative active site [active] 1205910008789 putative catalytic site [active] 1205910008790 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1205910008791 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1205910008792 metal binding site [ion binding]; metal-binding site 1205910008793 substrate binding pocket [chemical binding]; other site 1205910008794 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1205910008795 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1205910008796 hexamer interface [polypeptide binding]; other site 1205910008797 ligand binding site [chemical binding]; other site 1205910008798 putative active site [active] 1205910008799 NAD(P) binding site [chemical binding]; other site 1205910008800 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1205910008801 dihydroorotase; Validated; Region: pyrC; PRK09357 1205910008802 active site 1205910008803 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1205910008804 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1205910008805 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1205910008806 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910008807 Walker A/P-loop; other site 1205910008808 ATP binding site [chemical binding]; other site 1205910008809 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910008810 Q-loop/lid; other site 1205910008811 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1205910008812 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910008813 ABC transporter signature motif; other site 1205910008814 Walker B; other site 1205910008815 D-loop; other site 1205910008816 H-loop/switch region; other site 1205910008817 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1205910008818 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1205910008819 active site 1205910008820 metal binding site [ion binding]; metal-binding site 1205910008821 DNA binding site [nucleotide binding] 1205910008822 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1205910008823 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1205910008824 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910008825 S-adenosylmethionine binding site [chemical binding]; other site 1205910008826 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1205910008827 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1205910008828 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1205910008829 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1205910008830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910008831 dimer interface [polypeptide binding]; other site 1205910008832 conserved gate region; other site 1205910008833 putative PBP binding loops; other site 1205910008834 ABC-ATPase subunit interface; other site 1205910008835 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1205910008836 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910008837 dimer interface [polypeptide binding]; other site 1205910008838 conserved gate region; other site 1205910008839 putative PBP binding loops; other site 1205910008840 ABC-ATPase subunit interface; other site 1205910008841 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1205910008842 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1205910008843 Walker A/P-loop; other site 1205910008844 ATP binding site [chemical binding]; other site 1205910008845 Q-loop/lid; other site 1205910008846 ABC transporter signature motif; other site 1205910008847 Walker B; other site 1205910008848 D-loop; other site 1205910008849 H-loop/switch region; other site 1205910008850 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1205910008851 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1205910008852 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1205910008853 Walker A/P-loop; other site 1205910008854 ATP binding site [chemical binding]; other site 1205910008855 Q-loop/lid; other site 1205910008856 ABC transporter signature motif; other site 1205910008857 Walker B; other site 1205910008858 D-loop; other site 1205910008859 H-loop/switch region; other site 1205910008860 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1205910008861 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1205910008862 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1205910008863 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1205910008864 Fumarase C-terminus; Region: Fumerase_C; cl00795 1205910008865 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1205910008866 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 1205910008867 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1205910008868 putative active site [active] 1205910008869 putative dimer interface [polypeptide binding]; other site 1205910008870 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 1205910008871 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1205910008872 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1205910008873 dihydrodipicolinate reductase; Region: dapB; TIGR00036 1205910008874 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1205910008875 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1205910008876 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1205910008877 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910008878 S-adenosylmethionine binding site [chemical binding]; other site 1205910008879 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1205910008880 nudix motif; other site 1205910008881 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1205910008882 UbiA prenyltransferase family; Region: UbiA; pfam01040 1205910008883 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205910008884 Coenzyme A binding pocket [chemical binding]; other site 1205910008885 Predicted membrane protein [Function unknown]; Region: COG1950 1205910008886 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1205910008887 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1205910008888 dimer interface [polypeptide binding]; other site 1205910008889 active site 1205910008890 catalytic residue [active] 1205910008891 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1205910008892 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1205910008893 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1205910008894 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1205910008895 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205910008896 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1205910008897 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910008898 non-specific DNA binding site [nucleotide binding]; other site 1205910008899 salt bridge; other site 1205910008900 sequence-specific DNA binding site [nucleotide binding]; other site 1205910008901 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1205910008902 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 1205910008903 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1205910008904 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1205910008905 FeS/SAM binding site; other site 1205910008906 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1205910008907 Competence-damaged protein; Region: CinA; pfam02464 1205910008908 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910008909 sequence-specific DNA binding site [nucleotide binding]; other site 1205910008910 salt bridge; other site 1205910008911 Predicted transcriptional regulator [Transcription]; Region: COG1959 1205910008912 Transcriptional regulator; Region: Rrf2; pfam02082 1205910008913 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1205910008914 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1205910008915 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1205910008916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910008917 dimer interface [polypeptide binding]; other site 1205910008918 conserved gate region; other site 1205910008919 putative PBP binding loops; other site 1205910008920 ABC-ATPase subunit interface; other site 1205910008921 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1205910008922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1205910008923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910008924 putative PBP binding loops; other site 1205910008925 dimer interface [polypeptide binding]; other site 1205910008926 ABC-ATPase subunit interface; other site 1205910008927 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1205910008928 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1205910008929 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1205910008930 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1205910008931 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205910008932 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205910008933 active site 1205910008934 ATP binding site [chemical binding]; other site 1205910008935 substrate binding site [chemical binding]; other site 1205910008936 activation loop (A-loop); other site 1205910008937 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205910008938 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1205910008939 ATP binding site [chemical binding]; other site 1205910008940 putative Mg++ binding site [ion binding]; other site 1205910008941 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205910008942 nucleotide binding region [chemical binding]; other site 1205910008943 ATP-binding site [chemical binding]; other site 1205910008944 DEAD/H associated; Region: DEAD_assoc; pfam08494 1205910008945 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1205910008946 recombinase A; Provisional; Region: recA; PRK09354 1205910008947 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1205910008948 hexamer interface [polypeptide binding]; other site 1205910008949 Walker A motif; other site 1205910008950 ATP binding site [chemical binding]; other site 1205910008951 Walker B motif; other site 1205910008952 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1205910008953 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1205910008954 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1205910008955 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1205910008956 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910008957 dimer interface [polypeptide binding]; other site 1205910008958 conserved gate region; other site 1205910008959 putative PBP binding loops; other site 1205910008960 ABC-ATPase subunit interface; other site 1205910008961 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1205910008962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910008963 dimer interface [polypeptide binding]; other site 1205910008964 conserved gate region; other site 1205910008965 putative PBP binding loops; other site 1205910008966 ABC-ATPase subunit interface; other site 1205910008967 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1205910008968 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1205910008969 substrate binding pocket [chemical binding]; other site 1205910008970 membrane-bound complex binding site; other site 1205910008971 hinge residues; other site 1205910008972 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1205910008973 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1205910008974 Walker A/P-loop; other site 1205910008975 ATP binding site [chemical binding]; other site 1205910008976 Q-loop/lid; other site 1205910008977 ABC transporter signature motif; other site 1205910008978 Walker B; other site 1205910008979 D-loop; other site 1205910008980 H-loop/switch region; other site 1205910008981 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1205910008982 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1205910008983 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205910008984 FeS/SAM binding site; other site 1205910008985 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205910008986 Cytochrome P450; Region: p450; cl12078 1205910008987 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910008988 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910008989 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 1205910008990 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1205910008991 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1205910008992 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1205910008993 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1205910008994 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1205910008995 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1205910008996 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1205910008997 Walker A/P-loop; other site 1205910008998 ATP binding site [chemical binding]; other site 1205910008999 Q-loop/lid; other site 1205910009000 ABC transporter signature motif; other site 1205910009001 Walker B; other site 1205910009002 D-loop; other site 1205910009003 H-loop/switch region; other site 1205910009004 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 1205910009005 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 1205910009006 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1205910009007 Cysteine-rich domain; Region: CCG; pfam02754 1205910009008 Cysteine-rich domain; Region: CCG; pfam02754 1205910009009 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1205910009010 FAD binding domain; Region: FAD_binding_4; pfam01565 1205910009011 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1205910009012 FAD binding domain; Region: FAD_binding_4; pfam01565 1205910009013 malate synthase A; Region: malate_syn_A; TIGR01344 1205910009014 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1205910009015 active site 1205910009016 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1205910009017 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1205910009018 HflX GTPase family; Region: HflX; cd01878 1205910009019 G1 box; other site 1205910009020 GTP/Mg2+ binding site [chemical binding]; other site 1205910009021 Switch I region; other site 1205910009022 G2 box; other site 1205910009023 G3 box; other site 1205910009024 Switch II region; other site 1205910009025 G4 box; other site 1205910009026 G5 box; other site 1205910009027 imidazolonepropionase; Validated; Region: PRK09356 1205910009028 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1205910009029 active site 1205910009030 hypothetical protein; Validated; Region: PRK05629 1205910009031 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1205910009032 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1205910009033 Competence protein; Region: Competence; pfam03772 1205910009034 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1205910009035 comEA protein; Region: comE; TIGR01259 1205910009036 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 1205910009037 DNA binding site [nucleotide binding] 1205910009038 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1205910009039 GTP-binding protein LepA; Provisional; Region: PRK05433 1205910009040 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1205910009041 G1 box; other site 1205910009042 putative GEF interaction site [polypeptide binding]; other site 1205910009043 GTP/Mg2+ binding site [chemical binding]; other site 1205910009044 Switch I region; other site 1205910009045 G2 box; other site 1205910009046 G3 box; other site 1205910009047 Switch II region; other site 1205910009048 G4 box; other site 1205910009049 G5 box; other site 1205910009050 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1205910009051 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1205910009052 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1205910009053 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1205910009054 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910009055 dimer interface [polypeptide binding]; other site 1205910009056 conserved gate region; other site 1205910009057 putative PBP binding loops; other site 1205910009058 ABC-ATPase subunit interface; other site 1205910009059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910009060 dimer interface [polypeptide binding]; other site 1205910009061 conserved gate region; other site 1205910009062 putative PBP binding loops; other site 1205910009063 ABC-ATPase subunit interface; other site 1205910009064 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 1205910009065 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1205910009066 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1205910009067 active site 1205910009068 catalytic site [active] 1205910009069 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1205910009070 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 1205910009071 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 1205910009072 putative dimerization interface [polypeptide binding]; other site 1205910009073 putative ligand binding site [chemical binding]; other site 1205910009074 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1205910009075 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205910009076 FeS/SAM binding site; other site 1205910009077 Tic20-like protein; Region: Tic20; pfam09685 1205910009078 Tic20-like protein; Region: Tic20; pfam09685 1205910009079 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1205910009080 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1205910009081 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1205910009082 chaperone protein DnaJ; Provisional; Region: PRK14278 1205910009083 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1205910009084 HSP70 interaction site [polypeptide binding]; other site 1205910009085 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1205910009086 Zn binding sites [ion binding]; other site 1205910009087 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1205910009088 dimer interface [polypeptide binding]; other site 1205910009089 RNA methyltransferase, RsmE family; Region: TIGR00046 1205910009090 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1205910009091 Gammaherpesvirus latent membrane protein (LMP2) protein; Region: Herpes_LMP2; pfam07415 1205910009092 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1205910009093 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205910009094 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205910009095 DNA binding residues [nucleotide binding] 1205910009096 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1205910009097 nucleotide binding site/active site [active] 1205910009098 HIT family signature motif; other site 1205910009099 catalytic residue [active] 1205910009100 PhoH-like protein; Region: PhoH; pfam02562 1205910009101 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 1205910009102 Hom_end-associated Hint; Region: Hom_end_hint; pfam05203 1205910009103 thioester formation/cholesterol transfer; other site 1205910009104 Homing endonuclease; Region: Hom_end; pfam05204 1205910009105 PhoH-like protein; Region: PhoH; pfam02562 1205910009106 metal-binding heat shock protein; Provisional; Region: PRK00016 1205910009107 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1205910009108 Domain of unknown function DUF21; Region: DUF21; pfam01595 1205910009109 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1205910009110 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1205910009111 Transporter associated domain; Region: CorC_HlyC; smart01091 1205910009112 GTPase Era; Reviewed; Region: era; PRK00089 1205910009113 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1205910009114 G1 box; other site 1205910009115 GTP/Mg2+ binding site [chemical binding]; other site 1205910009116 Switch I region; other site 1205910009117 G2 box; other site 1205910009118 Switch II region; other site 1205910009119 G3 box; other site 1205910009120 G4 box; other site 1205910009121 G5 box; other site 1205910009122 KH domain; Region: KH_2; pfam07650 1205910009123 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1205910009124 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1205910009125 Bacterial transcriptional regulator; Region: IclR; pfam01614 1205910009126 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1205910009127 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1205910009128 active site 1205910009129 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1205910009130 allantoicase; Provisional; Region: PRK13257 1205910009131 Allantoicase repeat; Region: Allantoicase; pfam03561 1205910009132 Allantoicase repeat; Region: Allantoicase; pfam03561 1205910009133 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1205910009134 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1205910009135 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1205910009136 putative dimerization interface [polypeptide binding]; other site 1205910009137 xanthine permease; Region: pbuX; TIGR03173 1205910009138 urate oxidase; Region: urate_oxi; TIGR03383 1205910009139 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1205910009140 active site 1205910009141 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1205910009142 active site 1205910009143 homotetramer interface [polypeptide binding]; other site 1205910009144 putative OHCU decarboxylase; Provisional; Region: PRK13798 1205910009145 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 1205910009146 2-hydroxy-3-oxopropionate reductase; Region: tartro_sem_red; TIGR01505 1205910009147 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1205910009148 glyoxylate carboligase; Provisional; Region: PRK11269 1205910009149 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1205910009150 PYR/PP interface [polypeptide binding]; other site 1205910009151 dimer interface [polypeptide binding]; other site 1205910009152 TPP binding site [chemical binding]; other site 1205910009153 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1205910009154 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1205910009155 TPP-binding site [chemical binding]; other site 1205910009156 Peptidase M14 Carboxypeptidase T subfamily; Region: M14_CPT; cd03859 1205910009157 putative active site [active] 1205910009158 Zn binding site [ion binding]; other site 1205910009159 2-isopropylmalate synthase; Validated; Region: PRK03739 1205910009160 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1205910009161 active site 1205910009162 catalytic residues [active] 1205910009163 metal binding site [ion binding]; metal-binding site 1205910009164 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1205910009165 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1205910009166 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1205910009167 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1205910009168 Recombination protein O N terminal; Region: RecO_N; pfam11967 1205910009169 Recombination protein O C terminal; Region: RecO_C; pfam02565 1205910009170 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 1205910009171 active site 1205910009172 catalytic triad [active] 1205910009173 oxyanion hole [active] 1205910009174 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 1205910009175 putative catalytic site [active] 1205910009176 metal binding site A [ion binding]; metal-binding site 1205910009177 phosphate binding site [ion binding]; other site 1205910009178 metal binding site C [ion binding]; metal-binding site 1205910009179 metal binding site B [ion binding]; metal-binding site 1205910009180 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1205910009181 metal binding site 2 [ion binding]; metal-binding site 1205910009182 putative DNA binding helix; other site 1205910009183 metal binding site 1 [ion binding]; metal-binding site 1205910009184 dimer interface [polypeptide binding]; other site 1205910009185 structural Zn2+ binding site [ion binding]; other site 1205910009186 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1205910009187 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1205910009188 ABC-ATPase subunit interface; other site 1205910009189 dimer interface [polypeptide binding]; other site 1205910009190 putative PBP binding regions; other site 1205910009191 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1205910009192 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1205910009193 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1205910009194 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1205910009195 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1205910009196 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1205910009197 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1205910009198 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1205910009199 dimer interface [polypeptide binding]; other site 1205910009200 motif 1; other site 1205910009201 active site 1205910009202 motif 2; other site 1205910009203 motif 3; other site 1205910009204 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1205910009205 anticodon binding site; other site 1205910009206 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1205910009207 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1205910009208 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1205910009209 pyruvate phosphate dikinase; Provisional; Region: PRK09279 1205910009210 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1205910009211 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1205910009212 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1205910009213 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1205910009214 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1205910009215 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1205910009216 putative active site [active] 1205910009217 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1205910009218 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1205910009219 Zn2+ binding site [ion binding]; other site 1205910009220 Mg2+ binding site [ion binding]; other site 1205910009221 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1205910009222 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1205910009223 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1205910009224 metal ion-dependent adhesion site (MIDAS); other site 1205910009225 CHC2 zinc finger; Region: zf-CHC2; cl17510 1205910009226 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1205910009227 protein-splicing catalytic site; other site 1205910009228 thioester formation/cholesterol transfer; other site 1205910009229 DNA primase; Validated; Region: dnaG; PRK05667 1205910009230 CHC2 zinc finger; Region: zf-CHC2; cl17510 1205910009231 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1205910009232 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1205910009233 active site 1205910009234 metal binding site [ion binding]; metal-binding site 1205910009235 interdomain interaction site; other site 1205910009236 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1205910009237 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1205910009238 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1205910009239 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1205910009240 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205910009241 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1205910009242 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205910009243 DNA binding residues [nucleotide binding] 1205910009244 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1205910009245 Glyco_18 domain; Region: Glyco_18; smart00636 1205910009246 active site 1205910009247 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1205910009248 FAD binding domain; Region: FAD_binding_4; pfam01565 1205910009249 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1205910009250 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910009251 S-adenosylmethionine binding site [chemical binding]; other site 1205910009252 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1205910009253 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1205910009254 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910009255 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1205910009256 Walker A/P-loop; other site 1205910009257 ATP binding site [chemical binding]; other site 1205910009258 Q-loop/lid; other site 1205910009259 ABC transporter signature motif; other site 1205910009260 Walker B; other site 1205910009261 D-loop; other site 1205910009262 H-loop/switch region; other site 1205910009263 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 1205910009264 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 1205910009265 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1205910009266 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1205910009267 Ligand Binding Site [chemical binding]; other site 1205910009268 Molecular Tunnel; other site 1205910009269 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 1205910009270 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1205910009271 Histidine kinase; Region: HisKA_3; pfam07730 1205910009272 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205910009273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910009274 active site 1205910009275 phosphorylation site [posttranslational modification] 1205910009276 intermolecular recognition site; other site 1205910009277 dimerization interface [polypeptide binding]; other site 1205910009278 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205910009279 DNA binding residues [nucleotide binding] 1205910009280 dimerization interface [polypeptide binding]; other site 1205910009281 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1205910009282 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1205910009283 RibD C-terminal domain; Region: RibD_C; cl17279 1205910009284 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1205910009285 catalytic motif [active] 1205910009286 Zn binding site [ion binding]; other site 1205910009287 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205910009288 ATP binding site [chemical binding]; other site 1205910009289 putative Mg++ binding site [ion binding]; other site 1205910009290 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205910009291 nucleotide binding region [chemical binding]; other site 1205910009292 ATP-binding site [chemical binding]; other site 1205910009293 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 1205910009294 malate dehydrogenase; Provisional; Region: PRK05442 1205910009295 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1205910009296 NAD(P) binding site [chemical binding]; other site 1205910009297 dimer interface [polypeptide binding]; other site 1205910009298 malate binding site [chemical binding]; other site 1205910009299 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 1205910009300 active site 1205910009301 catalytic triad [active] 1205910009302 oxyanion hole [active] 1205910009303 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910009304 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 1205910009305 active site 1205910009306 catalytic site [active] 1205910009307 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1205910009308 metal binding site [ion binding]; metal-binding site 1205910009309 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1205910009310 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1205910009311 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1205910009312 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1205910009313 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205910009314 active site 1205910009315 metal binding site [ion binding]; metal-binding site 1205910009316 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1205910009317 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910009318 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 1205910009319 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1205910009320 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205910009321 putative DNA binding site [nucleotide binding]; other site 1205910009322 putative Zn2+ binding site [ion binding]; other site 1205910009323 AsnC family; Region: AsnC_trans_reg; pfam01037 1205910009324 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1205910009325 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 1205910009326 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 1205910009327 kynureninase; Region: kynureninase; TIGR01814 1205910009328 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205910009329 catalytic residue [active] 1205910009330 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1205910009331 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205910009332 putative DNA binding site [nucleotide binding]; other site 1205910009333 putative Zn2+ binding site [ion binding]; other site 1205910009334 AsnC family; Region: AsnC_trans_reg; pfam01037 1205910009335 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1205910009336 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1205910009337 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1205910009338 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1205910009339 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1205910009340 substrate binding site [chemical binding]; other site 1205910009341 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1205910009342 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1205910009343 homodimer interface [polypeptide binding]; other site 1205910009344 active site 1205910009345 TDP-binding site; other site 1205910009346 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1205910009347 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 1205910009348 PAC2 family; Region: PAC2; pfam09754 1205910009349 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1205910009350 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1205910009351 quinone interaction residues [chemical binding]; other site 1205910009352 active site 1205910009353 catalytic residues [active] 1205910009354 FMN binding site [chemical binding]; other site 1205910009355 substrate binding site [chemical binding]; other site 1205910009356 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1205910009357 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1205910009358 NodB motif; other site 1205910009359 active site 1205910009360 catalytic site [active] 1205910009361 metal binding site [ion binding]; metal-binding site 1205910009362 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1205910009363 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1205910009364 NodB motif; other site 1205910009365 active site 1205910009366 catalytic site [active] 1205910009367 metal binding site [ion binding]; metal-binding site 1205910009368 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 1205910009369 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 1205910009370 methionine synthase; Provisional; Region: PRK01207 1205910009371 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1205910009372 substrate binding site [chemical binding]; other site 1205910009373 THF binding site; other site 1205910009374 zinc-binding site [ion binding]; other site 1205910009375 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1205910009376 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1205910009377 Walker A/P-loop; other site 1205910009378 ATP binding site [chemical binding]; other site 1205910009379 Q-loop/lid; other site 1205910009380 ABC transporter signature motif; other site 1205910009381 Walker B; other site 1205910009382 D-loop; other site 1205910009383 H-loop/switch region; other site 1205910009384 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1205910009385 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910009386 dimer interface [polypeptide binding]; other site 1205910009387 conserved gate region; other site 1205910009388 ABC-ATPase subunit interface; other site 1205910009389 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1205910009390 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1205910009391 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1205910009392 beta-galactosidase; Region: BGL; TIGR03356 1205910009393 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1205910009394 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1205910009395 DNA binding site [nucleotide binding] 1205910009396 domain linker motif; other site 1205910009397 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 1205910009398 putative dimerization interface [polypeptide binding]; other site 1205910009399 putative ligand binding site [chemical binding]; other site 1205910009400 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1205910009401 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1205910009402 Nitrate and nitrite sensing; Region: NIT; pfam08376 1205910009403 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1205910009404 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1205910009405 dimerization interface [polypeptide binding]; other site 1205910009406 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910009407 ATP binding site [chemical binding]; other site 1205910009408 Mg2+ binding site [ion binding]; other site 1205910009409 G-X-G motif; other site 1205910009410 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 1205910009411 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1205910009412 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1205910009413 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1205910009414 G2 box; other site 1205910009415 Switch I region; other site 1205910009416 G3 box; other site 1205910009417 Switch II region; other site 1205910009418 GTP/Mg2+ binding site [chemical binding]; other site 1205910009419 G4 box; other site 1205910009420 G5 box; other site 1205910009421 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1205910009422 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1205910009423 nucleotide binding site/active site [active] 1205910009424 HIT family signature motif; other site 1205910009425 catalytic residue [active] 1205910009426 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1205910009427 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1205910009428 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1205910009429 putative acyl-acceptor binding pocket; other site 1205910009430 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1205910009431 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1205910009432 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1205910009433 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1205910009434 active site 1205910009435 multimer interface [polypeptide binding]; other site 1205910009436 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1205910009437 predicted active site [active] 1205910009438 catalytic triad [active] 1205910009439 hypothetical protein; Validated; Region: PRK00110 1205910009440 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1205910009441 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1205910009442 active site 1205910009443 putative DNA-binding cleft [nucleotide binding]; other site 1205910009444 dimer interface [polypeptide binding]; other site 1205910009445 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1205910009446 RuvA N terminal domain; Region: RuvA_N; pfam01330 1205910009447 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1205910009448 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205910009449 Walker A motif; other site 1205910009450 ATP binding site [chemical binding]; other site 1205910009451 Walker B motif; other site 1205910009452 arginine finger; other site 1205910009453 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1205910009454 Preprotein translocase subunit; Region: YajC; pfam02699 1205910009455 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1205910009456 active site 1205910009457 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1205910009458 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1205910009459 Zn2+ binding site [ion binding]; other site 1205910009460 Mg2+ binding site [ion binding]; other site 1205910009461 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1205910009462 synthetase active site [active] 1205910009463 NTP binding site [chemical binding]; other site 1205910009464 metal binding site [ion binding]; metal-binding site 1205910009465 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1205910009466 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1205910009467 Domain of unknown function (DUF385); Region: DUF385; cl04387 1205910009468 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205910009469 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205910009470 active site 1205910009471 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1205910009472 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1205910009473 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 1205910009474 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1205910009475 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1205910009476 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205910009477 catalytic residue [active] 1205910009478 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1205910009479 DinB superfamily; Region: DinB_2; pfam12867 1205910009480 primosome assembly protein PriA; Provisional; Region: PRK14873 1205910009481 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1205910009482 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1205910009483 putative active site [active] 1205910009484 substrate binding site [chemical binding]; other site 1205910009485 putative cosubstrate binding site; other site 1205910009486 catalytic site [active] 1205910009487 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1205910009488 substrate binding site [chemical binding]; other site 1205910009489 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1205910009490 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1205910009491 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1205910009492 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1205910009493 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1205910009494 substrate binding site [chemical binding]; other site 1205910009495 hexamer interface [polypeptide binding]; other site 1205910009496 metal binding site [ion binding]; metal-binding site 1205910009497 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1205910009498 active site 1205910009499 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1205910009500 Lumazine binding domain; Region: Lum_binding; pfam00677 1205910009501 Lumazine binding domain; Region: Lum_binding; pfam00677 1205910009502 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1205910009503 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1205910009504 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1205910009505 dimerization interface [polypeptide binding]; other site 1205910009506 active site 1205910009507 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1205910009508 homopentamer interface [polypeptide binding]; other site 1205910009509 active site 1205910009510 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1205910009511 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1205910009512 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1205910009513 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1205910009514 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1205910009515 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1205910009516 metal-binding site 1205910009517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910009518 S-adenosylmethionine binding site [chemical binding]; other site 1205910009519 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205910009520 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205910009521 active site 1205910009522 ATP binding site [chemical binding]; other site 1205910009523 substrate binding site [chemical binding]; other site 1205910009524 activation loop (A-loop); other site 1205910009525 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 1205910009526 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1205910009527 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1205910009528 MarR family; Region: MarR_2; pfam12802 1205910009529 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1205910009530 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1205910009531 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1205910009532 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1205910009533 Tetramer interface [polypeptide binding]; other site 1205910009534 active site 1205910009535 FMN-binding site [chemical binding]; other site 1205910009536 shikimate kinase; Reviewed; Region: aroK; PRK00131 1205910009537 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1205910009538 ADP binding site [chemical binding]; other site 1205910009539 magnesium binding site [ion binding]; other site 1205910009540 putative shikimate binding site; other site 1205910009541 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1205910009542 active site 1205910009543 dimer interface [polypeptide binding]; other site 1205910009544 metal binding site [ion binding]; metal-binding site 1205910009545 elongation factor P; Validated; Region: PRK00529 1205910009546 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1205910009547 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1205910009548 RNA binding site [nucleotide binding]; other site 1205910009549 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1205910009550 RNA binding site [nucleotide binding]; other site 1205910009551 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1205910009552 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1205910009553 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910009554 S-adenosylmethionine binding site [chemical binding]; other site 1205910009555 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1205910009556 active site 1205910009557 DNA polymerase IV; Validated; Region: PRK02406 1205910009558 DNA binding site [nucleotide binding] 1205910009559 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1205910009560 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1205910009561 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1205910009562 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1205910009563 Protein of unknown function DUF58; Region: DUF58; pfam01882 1205910009564 MoxR-like ATPases [General function prediction only]; Region: COG0714 1205910009565 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205910009566 Walker A motif; other site 1205910009567 ATP binding site [chemical binding]; other site 1205910009568 Walker B motif; other site 1205910009569 arginine finger; other site 1205910009570 cell division protein MraZ; Reviewed; Region: PRK00326 1205910009571 MraZ protein; Region: MraZ; pfam02381 1205910009572 MraZ protein; Region: MraZ; pfam02381 1205910009573 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1205910009574 MraW methylase family; Region: Methyltransf_5; cl17771 1205910009575 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1205910009576 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1205910009577 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1205910009578 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1205910009579 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1205910009580 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1205910009581 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1205910009582 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1205910009583 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1205910009584 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1205910009585 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1205910009586 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1205910009587 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1205910009588 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1205910009589 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1205910009590 Mg++ binding site [ion binding]; other site 1205910009591 putative catalytic motif [active] 1205910009592 putative substrate binding site [chemical binding]; other site 1205910009593 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 1205910009594 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1205910009595 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1205910009596 cell division protein FtsW; Region: ftsW; TIGR02614 1205910009597 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1205910009598 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1205910009599 active site 1205910009600 homodimer interface [polypeptide binding]; other site 1205910009601 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1205910009602 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1205910009603 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1205910009604 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1205910009605 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1205910009606 Cell division protein FtsQ; Region: FtsQ; pfam03799 1205910009607 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 1205910009608 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1205910009609 nucleotide binding site [chemical binding]; other site 1205910009610 SulA interaction site; other site 1205910009611 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1205910009612 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1205910009613 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1205910009614 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1205910009615 catalytic residue [active] 1205910009616 Protein of unknown function (DUF552); Region: DUF552; pfam04472 1205910009617 YGGT family; Region: YGGT; pfam02325 1205910009618 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1205910009619 DivIVA domain; Region: DivI1A_domain; TIGR03544 1205910009620 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 1205910009621 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1205910009622 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1205910009623 HIGH motif; other site 1205910009624 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1205910009625 active site 1205910009626 KMSKS motif; other site 1205910009627 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1205910009628 tRNA binding surface [nucleotide binding]; other site 1205910009629 anticodon binding site; other site 1205910009630 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1205910009631 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1205910009632 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1205910009633 lipoprotein signal peptidase; Provisional; Region: PRK14764 1205910009634 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1205910009635 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1205910009636 RNA binding surface [nucleotide binding]; other site 1205910009637 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1205910009638 active site 1205910009639 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1205910009640 EamA-like transporter family; Region: EamA; pfam00892 1205910009641 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1205910009642 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1205910009643 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1205910009644 putative dimerization interface [polypeptide binding]; other site 1205910009645 thiamine pyrophosphate protein; Validated; Region: PRK08199 1205910009646 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1205910009647 PYR/PP interface [polypeptide binding]; other site 1205910009648 dimer interface [polypeptide binding]; other site 1205910009649 TPP binding site [chemical binding]; other site 1205910009650 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1205910009651 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1205910009652 TPP-binding site [chemical binding]; other site 1205910009653 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 1205910009654 AzlC protein; Region: AzlC; cl00570 1205910009655 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1205910009656 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1205910009657 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1205910009658 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1205910009659 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205910009660 Coenzyme A binding pocket [chemical binding]; other site 1205910009661 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1205910009662 CoenzymeA binding site [chemical binding]; other site 1205910009663 subunit interaction site [polypeptide binding]; other site 1205910009664 PHB binding site; other site 1205910009665 Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372 1205910009666 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1205910009667 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1205910009668 active site 1205910009669 PHP Thumb interface [polypeptide binding]; other site 1205910009670 metal binding site [ion binding]; metal-binding site 1205910009671 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1205910009672 generic binding surface II; other site 1205910009673 generic binding surface I; other site 1205910009674 Predicted transcriptional regulators [Transcription]; Region: COG1695 1205910009675 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1205910009676 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1205910009677 DinB superfamily; Region: DinB_2; pfam12867 1205910009678 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1205910009679 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205910009680 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1205910009681 acyl-activating enzyme (AAE) consensus motif; other site 1205910009682 putative AMP binding site [chemical binding]; other site 1205910009683 putative active site [active] 1205910009684 putative CoA binding site [chemical binding]; other site 1205910009685 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1205910009686 putative deacylase active site [active] 1205910009687 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 1205910009688 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1205910009689 Ferritin-like domain; Region: Ferritin; pfam00210 1205910009690 ferroxidase diiron center [ion binding]; other site 1205910009691 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1205910009692 NAD binding site [chemical binding]; other site 1205910009693 dimerization interface [polypeptide binding]; other site 1205910009694 product binding site; other site 1205910009695 substrate binding site [chemical binding]; other site 1205910009696 zinc binding site [ion binding]; other site 1205910009697 catalytic residues [active] 1205910009698 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1205910009699 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205910009700 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910009701 homodimer interface [polypeptide binding]; other site 1205910009702 catalytic residue [active] 1205910009703 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1205910009704 putative active site pocket [active] 1205910009705 4-fold oligomerization interface [polypeptide binding]; other site 1205910009706 metal binding residues [ion binding]; metal-binding site 1205910009707 3-fold/trimer interface [polypeptide binding]; other site 1205910009708 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1205910009709 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1205910009710 putative active site [active] 1205910009711 oxyanion strand; other site 1205910009712 catalytic triad [active] 1205910009713 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1205910009714 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1205910009715 catalytic residues [active] 1205910009716 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1205910009717 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1205910009718 substrate binding site [chemical binding]; other site 1205910009719 glutamase interaction surface [polypeptide binding]; other site 1205910009720 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1205910009721 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1205910009722 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1205910009723 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1205910009724 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1205910009725 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1205910009726 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1205910009727 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1205910009728 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910009729 Walker A/P-loop; other site 1205910009730 ATP binding site [chemical binding]; other site 1205910009731 Q-loop/lid; other site 1205910009732 ABC transporter signature motif; other site 1205910009733 Walker B; other site 1205910009734 D-loop; other site 1205910009735 H-loop/switch region; other site 1205910009736 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1205910009737 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1205910009738 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910009739 Walker A/P-loop; other site 1205910009740 ATP binding site [chemical binding]; other site 1205910009741 Q-loop/lid; other site 1205910009742 ABC transporter signature motif; other site 1205910009743 Walker B; other site 1205910009744 D-loop; other site 1205910009745 H-loop/switch region; other site 1205910009746 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1205910009747 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; cl17850 1205910009748 Interferon-induced transmembrane protein; Region: CD225; pfam04505 1205910009749 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1205910009750 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1205910009751 active site 1205910009752 ribulose/triose binding site [chemical binding]; other site 1205910009753 phosphate binding site [ion binding]; other site 1205910009754 substrate (anthranilate) binding pocket [chemical binding]; other site 1205910009755 product (indole) binding pocket [chemical binding]; other site 1205910009756 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1205910009757 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1205910009758 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910009759 catalytic residue [active] 1205910009760 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1205910009761 substrate binding site [chemical binding]; other site 1205910009762 active site 1205910009763 catalytic residues [active] 1205910009764 heterodimer interface [polypeptide binding]; other site 1205910009765 Methylamine utilisation protein MauE; Region: MauE; pfam07291 1205910009766 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1205910009767 catalytic residues [active] 1205910009768 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1205910009769 Protein of unknown function DUF43; Region: DUF43; pfam01861 1205910009770 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1205910009771 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1205910009772 active site 1205910009773 dimer interface [polypeptide binding]; other site 1205910009774 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1205910009775 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1205910009776 active site 1205910009777 FMN binding site [chemical binding]; other site 1205910009778 substrate binding site [chemical binding]; other site 1205910009779 3Fe-4S cluster binding site [ion binding]; other site 1205910009780 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1205910009781 domain interface; other site 1205910009782 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1205910009783 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205910009784 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205910009785 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 1205910009786 TIGR03086 family protein; Region: TIGR03086 1205910009787 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1205910009788 pyruvate kinase; Provisional; Region: PRK06247 1205910009789 active site 1205910009790 domain interfaces; other site 1205910009791 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 1205910009792 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1205910009793 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1205910009794 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1205910009795 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1205910009796 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1205910009797 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1205910009798 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1205910009799 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205910009800 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1205910009801 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1205910009802 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1205910009803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910009804 active site 1205910009805 phosphorylation site [posttranslational modification] 1205910009806 intermolecular recognition site; other site 1205910009807 dimerization interface [polypeptide binding]; other site 1205910009808 ANTAR domain; Region: ANTAR; pfam03861 1205910009809 Cna protein B-type domain; Region: Cna_B; pfam05738 1205910009810 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1205910009811 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1205910009812 TM-ABC transporter signature motif; other site 1205910009813 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1205910009814 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1205910009815 TM-ABC transporter signature motif; other site 1205910009816 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1205910009817 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1205910009818 Walker A/P-loop; other site 1205910009819 ATP binding site [chemical binding]; other site 1205910009820 Q-loop/lid; other site 1205910009821 ABC transporter signature motif; other site 1205910009822 Walker B; other site 1205910009823 D-loop; other site 1205910009824 H-loop/switch region; other site 1205910009825 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1205910009826 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1205910009827 Walker A/P-loop; other site 1205910009828 ATP binding site [chemical binding]; other site 1205910009829 Q-loop/lid; other site 1205910009830 ABC transporter signature motif; other site 1205910009831 Walker B; other site 1205910009832 D-loop; other site 1205910009833 H-loop/switch region; other site 1205910009834 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1205910009835 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1205910009836 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1205910009837 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1205910009838 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1205910009839 CoenzymeA binding site [chemical binding]; other site 1205910009840 subunit interaction site [polypeptide binding]; other site 1205910009841 PHB binding site; other site 1205910009842 DNA polymerase I; Provisional; Region: PRK05755 1205910009843 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1205910009844 active site 1205910009845 metal binding site 1 [ion binding]; metal-binding site 1205910009846 putative 5' ssDNA interaction site; other site 1205910009847 metal binding site 3; metal-binding site 1205910009848 metal binding site 2 [ion binding]; metal-binding site 1205910009849 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1205910009850 putative DNA binding site [nucleotide binding]; other site 1205910009851 putative metal binding site [ion binding]; other site 1205910009852 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1205910009853 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1205910009854 active site 1205910009855 DNA binding site [nucleotide binding] 1205910009856 catalytic site [active] 1205910009857 hypothetical protein; Provisional; Region: PRK09256 1205910009858 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1205910009859 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1205910009860 RNA binding site [nucleotide binding]; other site 1205910009861 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1205910009862 RNA binding site [nucleotide binding]; other site 1205910009863 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1205910009864 RNA binding site [nucleotide binding]; other site 1205910009865 S1 RNA binding domain; Region: S1; pfam00575 1205910009866 RNA binding site [nucleotide binding]; other site 1205910009867 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1205910009868 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1205910009869 CoA-binding site [chemical binding]; other site 1205910009870 ATP-binding [chemical binding]; other site 1205910009871 excinuclease ABC subunit B; Provisional; Region: PRK05298 1205910009872 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205910009873 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205910009874 nucleotide binding region [chemical binding]; other site 1205910009875 ATP-binding site [chemical binding]; other site 1205910009876 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1205910009877 UvrB/uvrC motif; Region: UVR; pfam02151 1205910009878 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1205910009879 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205910009880 Coenzyme A binding pocket [chemical binding]; other site 1205910009881 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1205910009882 active site 1205910009883 catalytic residues [active] 1205910009884 metal binding site [ion binding]; metal-binding site 1205910009885 CTP synthetase; Validated; Region: pyrG; PRK05380 1205910009886 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1205910009887 Catalytic site [active] 1205910009888 active site 1205910009889 UTP binding site [chemical binding]; other site 1205910009890 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1205910009891 active site 1205910009892 putative oxyanion hole; other site 1205910009893 catalytic triad [active] 1205910009894 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1205910009895 dimer interface [polypeptide binding]; other site 1205910009896 ADP-ribose binding site [chemical binding]; other site 1205910009897 active site 1205910009898 nudix motif; other site 1205910009899 metal binding site [ion binding]; metal-binding site 1205910009900 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1205910009901 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1205910009902 active site 1205910009903 DNA binding site [nucleotide binding] 1205910009904 Int/Topo IB signature motif; other site 1205910009905 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1205910009906 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1205910009907 P-loop; other site 1205910009908 Magnesium ion binding site [ion binding]; other site 1205910009909 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1205910009910 Magnesium ion binding site [ion binding]; other site 1205910009911 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1205910009912 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1205910009913 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1205910009914 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1205910009915 active site 1205910009916 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 1205910009917 homotrimer interaction site [polypeptide binding]; other site 1205910009918 active site 1205910009919 prephenate dehydrogenase; Validated; Region: PRK06545 1205910009920 prephenate dehydrogenase; Validated; Region: PRK08507 1205910009921 cytidylate kinase; Provisional; Region: cmk; PRK00023 1205910009922 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1205910009923 CMP-binding site; other site 1205910009924 The sites determining sugar specificity; other site 1205910009925 GTP-binding protein Der; Reviewed; Region: PRK03003 1205910009926 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1205910009927 G1 box; other site 1205910009928 GTP/Mg2+ binding site [chemical binding]; other site 1205910009929 Switch I region; other site 1205910009930 G2 box; other site 1205910009931 Switch II region; other site 1205910009932 G3 box; other site 1205910009933 G4 box; other site 1205910009934 G5 box; other site 1205910009935 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1205910009936 G1 box; other site 1205910009937 GTP/Mg2+ binding site [chemical binding]; other site 1205910009938 Switch I region; other site 1205910009939 G2 box; other site 1205910009940 G3 box; other site 1205910009941 Switch II region; other site 1205910009942 G4 box; other site 1205910009943 G5 box; other site 1205910009944 Predicted membrane protein [Function unknown]; Region: COG2311 1205910009945 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1205910009946 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1205910009947 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1205910009948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910009949 metabolite-proton symporter; Region: 2A0106; TIGR00883 1205910009950 putative substrate translocation pore; other site 1205910009951 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1205910009952 RibD C-terminal domain; Region: RibD_C; cl17279 1205910009953 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1205910009954 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1205910009955 Amino acid permease; Region: AA_permease_2; pfam13520 1205910009956 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 1205910009957 active site flap/lid [active] 1205910009958 nucleophilic elbow; other site 1205910009959 catalytic triad [active] 1205910009960 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1205910009961 Coenzyme A binding pocket [chemical binding]; other site 1205910009962 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1205910009963 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1205910009964 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 1205910009965 homotrimer interaction site [polypeptide binding]; other site 1205910009966 putative active site [active] 1205910009967 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1205910009968 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1205910009969 putative dimer interface [polypeptide binding]; other site 1205910009970 N-terminal domain interface [polypeptide binding]; other site 1205910009971 putative substrate binding pocket (H-site) [chemical binding]; other site 1205910009972 metallophosphoesterase, PPA1498 family; Region: P_acnes_RR; cl17623 1205910009973 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1205910009974 homodimer interaction site [polypeptide binding]; other site 1205910009975 cofactor binding site; other site 1205910009976 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1205910009977 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205910009978 DNA binding residues [nucleotide binding] 1205910009979 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 1205910009980 putative dimer interface [polypeptide binding]; other site 1205910009981 ligand binding site [chemical binding]; other site 1205910009982 Zn binding site [ion binding]; other site 1205910009983 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722 1205910009984 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1205910009985 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1205910009986 Walker A/P-loop; other site 1205910009987 ATP binding site [chemical binding]; other site 1205910009988 Q-loop/lid; other site 1205910009989 ABC transporter signature motif; other site 1205910009990 Walker B; other site 1205910009991 D-loop; other site 1205910009992 H-loop/switch region; other site 1205910009993 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1205910009994 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1205910009995 dimer interface [polypeptide binding]; other site 1205910009996 putative PBP binding regions; other site 1205910009997 ABC-ATPase subunit interface; other site 1205910009998 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1205910009999 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1205910010000 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1205910010001 ABC-ATPase subunit interface; other site 1205910010002 dimer interface [polypeptide binding]; other site 1205910010003 putative PBP binding regions; other site 1205910010004 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1205910010005 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1205910010006 siderophore binding site; other site 1205910010007 Protease prsW family; Region: PrsW-protease; pfam13367 1205910010008 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1205910010009 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1205910010010 Trp docking motif [polypeptide binding]; other site 1205910010011 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1205910010012 active site 1205910010013 Phosphotransferase enzyme family; Region: APH; pfam01636 1205910010014 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1205910010015 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1205910010016 active site 1205910010017 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1205910010018 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1205910010019 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1205910010020 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1205910010021 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1205910010022 putative NAD(P) binding site [chemical binding]; other site 1205910010023 putative active site [active] 1205910010024 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1205910010025 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205910010026 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1205910010027 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 1205910010028 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1205910010029 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205910010030 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1205910010031 active site 1205910010032 metal binding site [ion binding]; metal-binding site 1205910010033 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1205910010034 CGNR zinc finger; Region: zf-CGNR; pfam11706 1205910010035 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1205910010036 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 1205910010037 NAD binding site [chemical binding]; other site 1205910010038 substrate binding site [chemical binding]; other site 1205910010039 catalytic Zn binding site [ion binding]; other site 1205910010040 structural Zn binding site [ion binding]; other site 1205910010041 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1205910010042 active site 1205910010043 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205910010044 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205910010045 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1205910010046 active site 1205910010047 RNA polymerase sigma-70 factor, TIGR02960 family; Region: SigX5 1205910010048 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205910010049 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205910010050 DNA binding residues [nucleotide binding] 1205910010051 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1205910010052 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1205910010053 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1205910010054 active site 1205910010055 homodimer interface [polypeptide binding]; other site 1205910010056 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 1205910010057 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 1205910010058 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 1205910010059 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1205910010060 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1205910010061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910010062 dimer interface [polypeptide binding]; other site 1205910010063 conserved gate region; other site 1205910010064 putative PBP binding loops; other site 1205910010065 ABC-ATPase subunit interface; other site 1205910010066 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1205910010067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910010068 ABC-ATPase subunit interface; other site 1205910010069 putative PBP binding loops; other site 1205910010070 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1205910010071 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1205910010072 Walker A/P-loop; other site 1205910010073 ATP binding site [chemical binding]; other site 1205910010074 Q-loop/lid; other site 1205910010075 ABC transporter signature motif; other site 1205910010076 Walker B; other site 1205910010077 D-loop; other site 1205910010078 H-loop/switch region; other site 1205910010079 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1205910010080 Walker A/P-loop; other site 1205910010081 ATP binding site [chemical binding]; other site 1205910010082 Q-loop/lid; other site 1205910010083 ABC transporter signature motif; other site 1205910010084 Walker B; other site 1205910010085 D-loop; other site 1205910010086 H-loop/switch region; other site 1205910010087 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1205910010088 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 1205910010089 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1205910010090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 1205910010091 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1205910010092 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1205910010093 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1205910010094 classical (c) SDRs; Region: SDR_c; cd05233 1205910010095 NAD(P) binding site [chemical binding]; other site 1205910010096 active site 1205910010097 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1205910010098 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1205910010099 Clp amino terminal domain; Region: Clp_N; pfam02861 1205910010100 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205910010101 Walker A motif; other site 1205910010102 ATP binding site [chemical binding]; other site 1205910010103 Walker B motif; other site 1205910010104 arginine finger; other site 1205910010105 UvrB/uvrC motif; Region: UVR; pfam02151 1205910010106 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205910010107 Walker A motif; other site 1205910010108 ATP binding site [chemical binding]; other site 1205910010109 Walker B motif; other site 1205910010110 arginine finger; other site 1205910010111 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1205910010112 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 1205910010113 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1205910010114 homodimer interface [polypeptide binding]; other site 1205910010115 substrate-cofactor binding pocket; other site 1205910010116 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910010117 catalytic residue [active] 1205910010118 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1205910010119 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1205910010120 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1205910010121 nucleotide binding site [chemical binding]; other site 1205910010122 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1205910010123 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1205910010124 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1205910010125 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1205910010126 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1205910010127 dimer interface [polypeptide binding]; other site 1205910010128 active site 1205910010129 non-prolyl cis peptide bond; other site 1205910010130 insertion regions; other site 1205910010131 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1205910010132 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205910010133 active site 1205910010134 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1205910010135 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1205910010136 active site residue [active] 1205910010137 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1205910010138 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1205910010139 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1205910010140 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1205910010141 NMT1-like family; Region: NMT1_2; pfam13379 1205910010142 substrate binding pocket [chemical binding]; other site 1205910010143 membrane-bound complex binding site; other site 1205910010144 hinge residues; other site 1205910010145 NMT1-like family; Region: NMT1_2; pfam13379 1205910010146 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1205910010147 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1205910010148 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1205910010149 Walker A/P-loop; other site 1205910010150 ATP binding site [chemical binding]; other site 1205910010151 Q-loop/lid; other site 1205910010152 ABC transporter signature motif; other site 1205910010153 Walker B; other site 1205910010154 D-loop; other site 1205910010155 H-loop/switch region; other site 1205910010156 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1205910010157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910010158 dimer interface [polypeptide binding]; other site 1205910010159 conserved gate region; other site 1205910010160 putative PBP binding loops; other site 1205910010161 ABC-ATPase subunit interface; other site 1205910010162 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1205910010163 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 1205910010164 putative active site [active] 1205910010165 metal binding site [ion binding]; metal-binding site 1205910010166 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1205910010167 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1205910010168 dimerization interface [polypeptide binding]; other site 1205910010169 DPS ferroxidase diiron center [ion binding]; other site 1205910010170 ion pore; other site 1205910010171 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1205910010172 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1205910010173 active site 1205910010174 catalytic tetrad [active] 1205910010175 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1205910010176 homotrimer interaction site [polypeptide binding]; other site 1205910010177 putative active site [active] 1205910010178 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1205910010179 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910010180 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910010181 NAD-dependent deacetylase; Provisional; Region: PRK00481 1205910010182 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1205910010183 NAD+ binding site [chemical binding]; other site 1205910010184 substrate binding site [chemical binding]; other site 1205910010185 Zn binding site [ion binding]; other site 1205910010186 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1205910010187 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1205910010188 ligand binding site [chemical binding]; other site 1205910010189 active site 1205910010190 UGI interface [polypeptide binding]; other site 1205910010191 catalytic site [active] 1205910010192 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1205910010193 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205910010194 active site 1205910010195 ATP binding site [chemical binding]; other site 1205910010196 substrate binding site [chemical binding]; other site 1205910010197 activation loop (A-loop); other site 1205910010198 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1205910010199 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205910010200 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205910010201 active site 1205910010202 ATP binding site [chemical binding]; other site 1205910010203 substrate binding site [chemical binding]; other site 1205910010204 activation loop (A-loop); other site 1205910010205 NPCBM/NEW2 domain; Region: NPCBM; cl07060 1205910010206 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1205910010207 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1205910010208 Predicted membrane protein [Function unknown]; Region: COG2364 1205910010209 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1205910010210 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1205910010211 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205910010212 DNA-binding site [nucleotide binding]; DNA binding site 1205910010213 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205910010214 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910010215 homodimer interface [polypeptide binding]; other site 1205910010216 catalytic residue [active] 1205910010217 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1205910010218 MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804 1205910010219 active site 1205910010220 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1205910010221 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1205910010222 PGAP1-like protein; Region: PGAP1; pfam07819 1205910010223 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1205910010224 catalytic site [active] 1205910010225 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1205910010226 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205910010227 FeS/SAM binding site; other site 1205910010228 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1205910010229 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1205910010230 hypothetical protein; Reviewed; Region: PRK09588 1205910010231 Dodecin; Region: Dodecin; pfam07311 1205910010232 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1205910010233 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1205910010234 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1205910010235 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1205910010236 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1205910010237 putative DNA binding site [nucleotide binding]; other site 1205910010238 putative Zn2+ binding site [ion binding]; other site 1205910010239 dihydropteroate synthase; Region: DHPS; TIGR01496 1205910010240 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1205910010241 substrate binding pocket [chemical binding]; other site 1205910010242 dimer interface [polypeptide binding]; other site 1205910010243 inhibitor binding site; inhibition site 1205910010244 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1205910010245 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205910010246 DNA-binding site [nucleotide binding]; DNA binding site 1205910010247 FCD domain; Region: FCD; pfam07729 1205910010248 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1205910010249 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910010250 putative substrate translocation pore; other site 1205910010251 CAAX protease self-immunity; Region: Abi; pfam02517 1205910010252 isocitrate lyase; Provisional; Region: PRK15063 1205910010253 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1205910010254 tetramer interface [polypeptide binding]; other site 1205910010255 active site 1205910010256 Mg2+/Mn2+ binding site [ion binding]; other site 1205910010257 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910010258 sequence-specific DNA binding site [nucleotide binding]; other site 1205910010259 salt bridge; other site 1205910010260 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1205910010261 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205910010262 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205910010263 active site 1205910010264 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910010265 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910010266 Protein of unknown function (DUF1032); Region: DUF1032; pfam06278 1205910010267 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1205910010268 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 1205910010269 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1205910010270 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1205910010271 tetramer interface [polypeptide binding]; other site 1205910010272 heme binding pocket [chemical binding]; other site 1205910010273 NADPH binding site [chemical binding]; other site 1205910010274 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1205910010275 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1205910010276 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205910010277 ATP binding site [chemical binding]; other site 1205910010278 putative Mg++ binding site [ion binding]; other site 1205910010279 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1205910010280 ATP-binding site [chemical binding]; other site 1205910010281 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1205910010282 Helix-turn-helix domain; Region: HTH_17; pfam12728 1205910010283 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1205910010284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910010285 S-adenosylmethionine binding site [chemical binding]; other site 1205910010286 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1205910010287 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1205910010288 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1205910010289 S-adenosylmethionine binding site [chemical binding]; other site 1205910010290 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1205910010291 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1205910010292 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1205910010293 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205910010294 active site 1205910010295 ATP binding site [chemical binding]; other site 1205910010296 substrate binding site [chemical binding]; other site 1205910010297 activation loop (A-loop); other site 1205910010298 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1205910010299 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1205910010300 AIPR protein; Region: AIPR; pfam10592 1205910010301 Uncharacterized conserved protein [Function unknown]; Region: COG4127 1205910010302 HNH endonuclease; Region: HNH_2; pfam13391 1205910010303 Caspase domain; Region: Peptidase_C14; pfam00656 1205910010304 Part of AAA domain; Region: AAA_19; pfam13245 1205910010305 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1205910010306 AAA domain; Region: AAA_12; pfam13087 1205910010307 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1205910010308 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1205910010309 TspO/MBR family; Region: TspO_MBR; pfam03073 1205910010310 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1205910010311 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1205910010312 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1205910010313 ligand binding site [chemical binding]; other site 1205910010314 flexible hinge region; other site 1205910010315 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1205910010316 substrate binding pocket [chemical binding]; other site 1205910010317 substrate-Mg2+ binding site; other site 1205910010318 aspartate-rich region 1; other site 1205910010319 aspartate-rich region 2; other site 1205910010320 tocopherol O-methyltransferase; Region: PLN02244 1205910010321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1205910010322 S-adenosylmethionine binding site [chemical binding]; other site 1205910010323 isopentenyl-diphosphate delta-isomerase; Provisional; Region: PRK03759 1205910010324 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 1205910010325 nudix motif; other site 1205910010326 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1205910010327 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 1205910010328 SWIM/SEC-C metal-binding motif protein, PBPRA1643 family; Region: SWIM_PBPRA1643; TIGR04102 1205910010329 SEC-C motif; Region: SEC-C; pfam02810 1205910010330 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1205910010331 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205910010332 DNA-binding site [nucleotide binding]; DNA binding site 1205910010333 UTRA domain; Region: UTRA; pfam07702 1205910010334 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 1205910010335 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1205910010336 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1205910010337 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 1205910010338 Part of AAA domain; Region: AAA_19; pfam13245 1205910010339 Family description; Region: UvrD_C_2; pfam13538 1205910010340 anthranilate synthase; Provisional; Region: PRK13566 1205910010341 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1205910010342 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1205910010343 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1205910010344 glutamine binding [chemical binding]; other site 1205910010345 catalytic triad [active] 1205910010346 Thymidylate synthase complementing protein; Region: Thy1; pfam02511 1205910010347 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1205910010348 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205910010349 catalytic residue [active] 1205910010350 cytosine deaminase; Provisional; Region: PRK05985 1205910010351 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1205910010352 active site 1205910010353 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1205910010354 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205910010355 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1205910010356 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1205910010357 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1205910010358 active site 1205910010359 Substrate binding site; other site 1205910010360 Mg++ binding site; other site 1205910010361 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1205910010362 putative trimer interface [polypeptide binding]; other site 1205910010363 putative CoA binding site [chemical binding]; other site 1205910010364 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 1205910010365 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 1205910010366 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1205910010367 Double zinc ribbon; Region: DZR; pfam12773 1205910010368 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1205910010369 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1205910010370 phosphopeptide binding site; other site 1205910010371 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1205910010372 glycine dehydrogenase; Provisional; Region: PRK05367 1205910010373 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1205910010374 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205910010375 catalytic residue [active] 1205910010376 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1205910010377 tetramer interface [polypeptide binding]; other site 1205910010378 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910010379 catalytic residue [active] 1205910010380 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1205910010381 binding surface 1205910010382 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1205910010383 TPR motif; other site 1205910010384 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1205910010385 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1205910010386 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1205910010387 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205910010388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910010389 active site 1205910010390 phosphorylation site [posttranslational modification] 1205910010391 intermolecular recognition site; other site 1205910010392 dimerization interface [polypeptide binding]; other site 1205910010393 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205910010394 DNA binding residues [nucleotide binding] 1205910010395 dimerization interface [polypeptide binding]; other site 1205910010396 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1205910010397 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 1205910010398 active site 1205910010399 putative substrate binding region [chemical binding]; other site 1205910010400 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1205910010401 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910010402 salt bridge; other site 1205910010403 non-specific DNA binding site [nucleotide binding]; other site 1205910010404 sequence-specific DNA binding site [nucleotide binding]; other site 1205910010405 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1205910010406 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1205910010407 nucleotide binding site [chemical binding]; other site 1205910010408 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1205910010409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1205910010410 proteasome ATPase; Region: pup_AAA; TIGR03689 1205910010411 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205910010412 Walker A motif; other site 1205910010413 ATP binding site [chemical binding]; other site 1205910010414 Walker B motif; other site 1205910010415 arginine finger; other site 1205910010416 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 1205910010417 tellurium resistance terB-like protein; Region: terB_like; cl11965 1205910010418 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 1205910010419 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1205910010420 Pup-like protein; Region: Pup; cl05289 1205910010421 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 1205910010422 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1205910010423 active site 1205910010424 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 1205910010425 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1205910010426 active site 1205910010427 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 1205910010428 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1205910010429 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1205910010430 active site 1205910010431 cosubstrate binding site; other site 1205910010432 substrate binding site [chemical binding]; other site 1205910010433 catalytic site [active] 1205910010434 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 1205910010435 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 1205910010436 Predicted transcriptional regulator [Transcription]; Region: COG2378 1205910010437 WYL domain; Region: WYL; pfam13280 1205910010438 Predicted transcriptional regulator [Transcription]; Region: COG2378 1205910010439 WYL domain; Region: WYL; pfam13280 1205910010440 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1205910010441 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1205910010442 diacylglycerol kinase; Reviewed; Region: PRK11914 1205910010443 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1205910010444 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1205910010445 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205910010446 ATP binding site [chemical binding]; other site 1205910010447 putative Mg++ binding site [ion binding]; other site 1205910010448 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205910010449 nucleotide binding region [chemical binding]; other site 1205910010450 ATP-binding site [chemical binding]; other site 1205910010451 rRNA-processing arch domain; Region: rRNA_proc-arch; pfam13234 1205910010452 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1205910010453 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1205910010454 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205910010455 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1205910010456 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1205910010457 tetramerization interface [polypeptide binding]; other site 1205910010458 active site 1205910010459 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1205910010460 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1205910010461 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910010462 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910010463 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1205910010464 Cupin superfamily protein; Region: Cupin_4; pfam08007 1205910010465 Cupin-like domain; Region: Cupin_8; pfam13621 1205910010466 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1205910010467 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1205910010468 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1205910010469 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1205910010470 Walker A/P-loop; other site 1205910010471 ATP binding site [chemical binding]; other site 1205910010472 Q-loop/lid; other site 1205910010473 ABC transporter signature motif; other site 1205910010474 Walker B; other site 1205910010475 D-loop; other site 1205910010476 H-loop/switch region; other site 1205910010477 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 1205910010478 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1205910010479 putative active site [active] 1205910010480 catalytic triad [active] 1205910010481 putative dimer interface [polypeptide binding]; other site 1205910010482 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 1205910010483 SnoaL-like domain; Region: SnoaL_2; pfam12680 1205910010484 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1205910010485 nudix motif; other site 1205910010486 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1205910010487 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205910010488 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1205910010489 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1205910010490 NRDE protein; Region: NRDE; cl01315 1205910010491 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 1205910010492 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1205910010493 active site 1205910010494 HIGH motif; other site 1205910010495 nucleotide binding site [chemical binding]; other site 1205910010496 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1205910010497 active site 1205910010498 KMSKS motif; other site 1205910010499 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 1205910010500 putative tRNA binding surface [nucleotide binding]; other site 1205910010501 Domain of unknown function (DUF385); Region: DUF385; cl04387 1205910010502 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1205910010503 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1205910010504 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205910010505 Coenzyme A binding pocket [chemical binding]; other site 1205910010506 Part of AAA domain; Region: AAA_19; pfam13245 1205910010507 Family description; Region: UvrD_C_2; pfam13538 1205910010508 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1205910010509 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 1205910010510 putative ADP-binding pocket [chemical binding]; other site 1205910010511 PAC2 family; Region: PAC2; pfam09754 1205910010512 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 1205910010513 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1205910010514 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1205910010515 substrate binding pocket [chemical binding]; other site 1205910010516 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1205910010517 B12 binding site [chemical binding]; other site 1205910010518 cobalt ligand [ion binding]; other site 1205910010519 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1205910010520 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1205910010521 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205910010522 motif II; other site 1205910010523 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1205910010524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910010525 dimer interface [polypeptide binding]; other site 1205910010526 conserved gate region; other site 1205910010527 putative PBP binding loops; other site 1205910010528 ABC-ATPase subunit interface; other site 1205910010529 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1205910010530 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 1205910010531 peptide binding site [polypeptide binding]; other site 1205910010532 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1205910010533 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1205910010534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910010535 dimer interface [polypeptide binding]; other site 1205910010536 conserved gate region; other site 1205910010537 putative PBP binding loops; other site 1205910010538 ABC-ATPase subunit interface; other site 1205910010539 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1205910010540 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1205910010541 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1205910010542 Walker A/P-loop; other site 1205910010543 ATP binding site [chemical binding]; other site 1205910010544 Q-loop/lid; other site 1205910010545 ABC transporter signature motif; other site 1205910010546 Walker B; other site 1205910010547 D-loop; other site 1205910010548 H-loop/switch region; other site 1205910010549 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1205910010550 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910010551 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910010552 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1205910010553 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1205910010554 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 1205910010555 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1205910010556 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1205910010557 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1205910010558 DNA binding residues [nucleotide binding] 1205910010559 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1205910010560 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1205910010561 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1205910010562 active site 1205910010563 trimer interface [polypeptide binding]; other site 1205910010564 dimer interface [polypeptide binding]; other site 1205910010565 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1205910010566 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1205910010567 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1205910010568 putative molybdopterin cofactor binding site [chemical binding]; other site 1205910010569 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1205910010570 putative molybdopterin cofactor binding site; other site 1205910010571 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1205910010572 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1205910010573 putative deacylase active site [active] 1205910010574 Sulphur transport; Region: Sulf_transp; pfam04143 1205910010575 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1205910010576 Yqey-like protein; Region: YqeY; cl17540 1205910010577 Cupin; Region: Cupin_6; pfam12852 1205910010578 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1205910010579 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1205910010580 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1205910010581 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1205910010582 H+ Antiporter protein; Region: 2A0121; TIGR00900 1205910010583 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1205910010584 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1205910010585 Domain of unknown function (DUF364); Region: DUF364; pfam04016 1205910010586 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 1205910010587 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1205910010588 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205910010589 catalytic residue [active] 1205910010590 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1205910010591 Protein of unknown function (DUF3374); Region: DUF3374; cl11904 1205910010592 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1205910010593 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205910010594 DNA-binding site [nucleotide binding]; DNA binding site 1205910010595 UTRA domain; Region: UTRA; pfam07702 1205910010596 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205910010597 putative DNA binding site [nucleotide binding]; other site 1205910010598 dimerization interface [polypeptide binding]; other site 1205910010599 putative Zn2+ binding site [ion binding]; other site 1205910010600 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1205910010601 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1205910010602 Walker A/P-loop; other site 1205910010603 ATP binding site [chemical binding]; other site 1205910010604 Q-loop/lid; other site 1205910010605 ABC transporter signature motif; other site 1205910010606 Walker B; other site 1205910010607 D-loop; other site 1205910010608 H-loop/switch region; other site 1205910010609 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1205910010610 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1205910010611 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1205910010612 Walker A/P-loop; other site 1205910010613 ATP binding site [chemical binding]; other site 1205910010614 Q-loop/lid; other site 1205910010615 ABC transporter signature motif; other site 1205910010616 Walker B; other site 1205910010617 D-loop; other site 1205910010618 H-loop/switch region; other site 1205910010619 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1205910010620 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1205910010621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910010622 dimer interface [polypeptide binding]; other site 1205910010623 conserved gate region; other site 1205910010624 putative PBP binding loops; other site 1205910010625 ABC-ATPase subunit interface; other site 1205910010626 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1205910010627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910010628 ABC-ATPase subunit interface; other site 1205910010629 putative PBP binding loops; other site 1205910010630 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1205910010631 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1205910010632 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 1205910010633 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1205910010634 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1205910010635 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1205910010636 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1205910010637 Mg2+ binding site [ion binding]; other site 1205910010638 Helix-turn-helix domain; Region: HTH_17; pfam12728 1205910010639 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1205910010640 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1205910010641 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910010642 non-specific DNA binding site [nucleotide binding]; other site 1205910010643 salt bridge; other site 1205910010644 sequence-specific DNA binding site [nucleotide binding]; other site 1205910010645 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1205910010646 DNA binding residues [nucleotide binding] 1205910010647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1205910010648 Nucleoside recognition; Region: Gate; pfam07670 1205910010649 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1205910010650 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1205910010651 intersubunit interface [polypeptide binding]; other site 1205910010652 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1205910010653 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1205910010654 Walker A/P-loop; other site 1205910010655 ATP binding site [chemical binding]; other site 1205910010656 Q-loop/lid; other site 1205910010657 ABC transporter signature motif; other site 1205910010658 Walker B; other site 1205910010659 D-loop; other site 1205910010660 H-loop/switch region; other site 1205910010661 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1205910010662 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1205910010663 dimer interface [polypeptide binding]; other site 1205910010664 putative PBP binding regions; other site 1205910010665 ABC-ATPase subunit interface; other site 1205910010666 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1205910010667 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1205910010668 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1205910010669 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1205910010670 intersubunit interface [polypeptide binding]; other site 1205910010671 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1205910010672 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1205910010673 ABC-ATPase subunit interface; other site 1205910010674 dimer interface [polypeptide binding]; other site 1205910010675 putative PBP binding regions; other site 1205910010676 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1205910010677 ABC-ATPase subunit interface; other site 1205910010678 dimer interface [polypeptide binding]; other site 1205910010679 putative PBP binding regions; other site 1205910010680 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1205910010681 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1205910010682 Walker A/P-loop; other site 1205910010683 ATP binding site [chemical binding]; other site 1205910010684 Q-loop/lid; other site 1205910010685 ABC transporter signature motif; other site 1205910010686 Walker B; other site 1205910010687 D-loop; other site 1205910010688 H-loop/switch region; other site 1205910010689 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1205910010690 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1205910010691 intersubunit interface [polypeptide binding]; other site 1205910010692 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1205910010693 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1205910010694 FAD binding pocket [chemical binding]; other site 1205910010695 FAD binding motif [chemical binding]; other site 1205910010696 phosphate binding motif [ion binding]; other site 1205910010697 NAD binding pocket [chemical binding]; other site 1205910010698 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1205910010699 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910010700 Walker A/P-loop; other site 1205910010701 ATP binding site [chemical binding]; other site 1205910010702 Q-loop/lid; other site 1205910010703 ABC transporter signature motif; other site 1205910010704 Walker B; other site 1205910010705 D-loop; other site 1205910010706 H-loop/switch region; other site 1205910010707 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1205910010708 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1205910010709 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910010710 Walker A/P-loop; other site 1205910010711 ATP binding site [chemical binding]; other site 1205910010712 Q-loop/lid; other site 1205910010713 ABC transporter signature motif; other site 1205910010714 Walker B; other site 1205910010715 D-loop; other site 1205910010716 H-loop/switch region; other site 1205910010717 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1205910010718 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205910010719 DNA-binding site [nucleotide binding]; DNA binding site 1205910010720 FCD domain; Region: FCD; pfam07729 1205910010721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910010722 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1205910010723 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1205910010724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1205910010725 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1205910010726 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910010727 putative PBP binding loops; other site 1205910010728 dimer interface [polypeptide binding]; other site 1205910010729 ABC-ATPase subunit interface; other site 1205910010730 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1205910010731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910010732 dimer interface [polypeptide binding]; other site 1205910010733 conserved gate region; other site 1205910010734 putative PBP binding loops; other site 1205910010735 ABC-ATPase subunit interface; other site 1205910010736 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1205910010737 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1205910010738 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1205910010739 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1205910010740 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1205910010741 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1205910010742 metal binding site [ion binding]; metal-binding site 1205910010743 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1205910010744 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1205910010745 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1205910010746 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 1205910010747 EF-hand domain pair; Region: EF_hand_5; pfam13499 1205910010748 Ca2+ binding site [ion binding]; other site 1205910010749 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1205910010750 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1205910010751 inhibitor-cofactor binding pocket; inhibition site 1205910010752 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910010753 catalytic residue [active] 1205910010754 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1205910010755 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1205910010756 inhibitor-cofactor binding pocket; inhibition site 1205910010757 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910010758 catalytic residue [active] 1205910010759 UbiA prenyltransferase family; Region: UbiA; pfam01040 1205910010760 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205910010761 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 1205910010762 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1205910010763 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205910010764 acyl-activating enzyme (AAE) consensus motif; other site 1205910010765 active site 1205910010766 AMP binding site [chemical binding]; other site 1205910010767 CoA binding site [chemical binding]; other site 1205910010768 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1205910010769 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1205910010770 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1205910010771 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205910010772 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205910010773 acyl-activating enzyme (AAE) consensus motif; other site 1205910010774 AMP binding site [chemical binding]; other site 1205910010775 active site 1205910010776 CoA binding site [chemical binding]; other site 1205910010777 hypothetical protein; Provisional; Region: PRK08317 1205910010778 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1205910010779 S-adenosylmethionine binding site [chemical binding]; other site 1205910010780 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1205910010781 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1205910010782 acyl-CoA synthetase; Validated; Region: PRK08316 1205910010783 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205910010784 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1205910010785 acyl-activating enzyme (AAE) consensus motif; other site 1205910010786 acyl-activating enzyme (AAE) consensus motif; other site 1205910010787 putative AMP binding site [chemical binding]; other site 1205910010788 putative active site [active] 1205910010789 putative CoA binding site [chemical binding]; other site 1205910010790 Cation efflux family; Region: Cation_efflux; pfam01545 1205910010791 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1205910010792 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1205910010793 DNA binding residues [nucleotide binding] 1205910010794 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1205910010795 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1205910010796 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1205910010797 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205910010798 Ligand Binding Site [chemical binding]; other site 1205910010799 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 1205910010800 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 1205910010801 putative NAD(P) binding site [chemical binding]; other site 1205910010802 putative substrate binding site [chemical binding]; other site 1205910010803 catalytic Zn binding site [ion binding]; other site 1205910010804 structural Zn binding site [ion binding]; other site 1205910010805 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1205910010806 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1205910010807 motif II; other site 1205910010808 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205910010809 Ligand Binding Site [chemical binding]; other site 1205910010810 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205910010811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910010812 active site 1205910010813 phosphorylation site [posttranslational modification] 1205910010814 intermolecular recognition site; other site 1205910010815 dimerization interface [polypeptide binding]; other site 1205910010816 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205910010817 DNA binding residues [nucleotide binding] 1205910010818 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1205910010819 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910010820 non-specific DNA binding site [nucleotide binding]; other site 1205910010821 salt bridge; other site 1205910010822 sequence-specific DNA binding site [nucleotide binding]; other site 1205910010823 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1205910010824 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1205910010825 A new structural DNA glycosylase; Region: AlkD_like; cd06561 1205910010826 active site 1205910010827 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910010828 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910010829 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1205910010830 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1205910010831 NAD(P) binding site [chemical binding]; other site 1205910010832 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205910010833 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1205910010834 active site 1205910010835 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1205910010836 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1205910010837 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205910010838 Coenzyme A binding pocket [chemical binding]; other site 1205910010839 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1205910010840 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 1205910010841 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1205910010842 NAD binding site [chemical binding]; other site 1205910010843 catalytic Zn binding site [ion binding]; other site 1205910010844 substrate binding site [chemical binding]; other site 1205910010845 structural Zn binding site [ion binding]; other site 1205910010846 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 1205910010847 putative active site; other site 1205910010848 putative metal binding residues [ion binding]; other site 1205910010849 signature motif; other site 1205910010850 putative triphosphate binding site [ion binding]; other site 1205910010851 H+ Antiporter protein; Region: 2A0121; TIGR00900 1205910010852 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910010853 putative substrate translocation pore; other site 1205910010854 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1205910010855 amidase catalytic site [active] 1205910010856 Zn binding residues [ion binding]; other site 1205910010857 substrate binding site [chemical binding]; other site 1205910010858 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1205910010859 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205910010860 NAD(P) binding site [chemical binding]; other site 1205910010861 active site 1205910010862 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1205910010863 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1205910010864 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1205910010865 acyl-activating enzyme (AAE) consensus motif; other site 1205910010866 active site 1205910010867 AMP binding site [chemical binding]; other site 1205910010868 substrate binding site [chemical binding]; other site 1205910010869 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1205910010870 Isochorismatase family; Region: Isochorismatase; pfam00857 1205910010871 catalytic triad [active] 1205910010872 conserved cis-peptide bond; other site 1205910010873 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1205910010874 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205910010875 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1205910010876 Condensation domain; Region: Condensation; pfam00668 1205910010877 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1205910010878 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1205910010879 acyl-activating enzyme (AAE) consensus motif; other site 1205910010880 AMP binding site [chemical binding]; other site 1205910010881 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205910010882 Condensation domain; Region: Condensation; pfam00668 1205910010883 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1205910010884 Condensation domain; Region: Condensation; pfam00668 1205910010885 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1205910010886 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205910010887 acyl-activating enzyme (AAE) consensus motif; other site 1205910010888 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1205910010889 AMP binding site [chemical binding]; other site 1205910010890 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205910010891 Condensation domain; Region: Condensation; pfam00668 1205910010892 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1205910010893 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1205910010894 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205910010895 acyl-activating enzyme (AAE) consensus motif; other site 1205910010896 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1205910010897 AMP binding site [chemical binding]; other site 1205910010898 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205910010899 Condensation domain; Region: Condensation; pfam00668 1205910010900 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1205910010901 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1205910010902 acyl-activating enzyme (AAE) consensus motif; other site 1205910010903 AMP binding site [chemical binding]; other site 1205910010904 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205910010905 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1205910010906 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1205910010907 acyl-activating enzyme (AAE) consensus motif; other site 1205910010908 AMP binding site [chemical binding]; other site 1205910010909 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205910010910 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1205910010911 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1205910010912 intersubunit interface [polypeptide binding]; other site 1205910010913 MbtH-like protein; Region: MbtH; cl01279 1205910010914 enterobactin exporter EntS; Provisional; Region: PRK10489 1205910010915 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910010916 putative substrate translocation pore; other site 1205910010917 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1205910010918 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1205910010919 FAD binding pocket [chemical binding]; other site 1205910010920 FAD binding motif [chemical binding]; other site 1205910010921 phosphate binding motif [ion binding]; other site 1205910010922 NAD binding pocket [chemical binding]; other site 1205910010923 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1205910010924 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1205910010925 Walker A/P-loop; other site 1205910010926 ATP binding site [chemical binding]; other site 1205910010927 Q-loop/lid; other site 1205910010928 ABC transporter signature motif; other site 1205910010929 Walker B; other site 1205910010930 D-loop; other site 1205910010931 H-loop/switch region; other site 1205910010932 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1205910010933 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1205910010934 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1205910010935 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1205910010936 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1205910010937 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 1205910010938 active site 1205910010939 substrate binding sites [chemical binding]; other site 1205910010940 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1205910010941 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910010942 putative substrate translocation pore; other site 1205910010943 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910010944 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1205910010945 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205910010946 motif II; other site 1205910010947 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 1205910010948 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1205910010949 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1205910010950 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205910010951 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205910010952 active site 1205910010953 Ectoine synthase; Region: Ectoine_synth; cl17598 1205910010954 acyl carrier protein; Provisional; Region: PRK07639 1205910010955 acyl-CoA synthetase; Validated; Region: PRK06164 1205910010956 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205910010957 active site 1205910010958 CoA binding site [chemical binding]; other site 1205910010959 AMP binding site [chemical binding]; other site 1205910010960 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1205910010961 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1205910010962 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205910010963 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205910010964 DNA binding residues [nucleotide binding] 1205910010965 dimerization interface [polypeptide binding]; other site 1205910010966 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1205910010967 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1205910010968 Protein of unknown function (DUF461); Region: DUF461; pfam04314 1205910010969 CopC domain; Region: CopC; pfam04234 1205910010970 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 1205910010971 EamA-like transporter family; Region: EamA; pfam00892 1205910010972 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1205910010973 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1205910010974 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1205910010975 dimerization interface [polypeptide binding]; other site 1205910010976 substrate binding pocket [chemical binding]; other site 1205910010977 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 1205910010978 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205910010979 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1205910010980 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1205910010981 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1205910010982 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1205910010983 active site 1205910010984 substrate binding site [chemical binding]; other site 1205910010985 trimer interface [polypeptide binding]; other site 1205910010986 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1205910010987 CoA binding site [chemical binding]; other site 1205910010988 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 1205910010989 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910010990 S-adenosylmethionine binding site [chemical binding]; other site 1205910010991 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1205910010992 RibD C-terminal domain; Region: RibD_C; cl17279 1205910010993 H+ Antiporter protein; Region: 2A0121; TIGR00900 1205910010994 H+ Antiporter protein; Region: 2A0121; TIGR00900 1205910010995 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1205910010996 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1205910010997 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 1205910010998 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205910010999 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 1205910011000 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1205910011001 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1205910011002 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1205910011003 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 1205910011004 conserved cys residue [active] 1205910011005 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1205910011006 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1205910011007 substrate binding site [chemical binding]; other site 1205910011008 ATP binding site [chemical binding]; other site 1205910011009 NB-ARC domain; Region: NB-ARC; pfam00931 1205910011010 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1205910011011 G1 box; other site 1205910011012 GTP/Mg2+ binding site [chemical binding]; other site 1205910011013 TPR repeat; Region: TPR_11; pfam13414 1205910011014 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1205910011015 TPR motif; other site 1205910011016 binding surface 1205910011017 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1205910011018 DNA binding site [nucleotide binding] 1205910011019 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1205910011020 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1205910011021 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1205910011022 binding surface 1205910011023 TPR motif; other site 1205910011024 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1205910011025 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1205910011026 TPR motif; other site 1205910011027 binding surface 1205910011028 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1205910011029 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1205910011030 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1205910011031 binding surface 1205910011032 TPR motif; other site 1205910011033 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205910011034 catalytic core [active] 1205910011035 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1205910011036 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1205910011037 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1205910011038 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1205910011039 Coenzyme A binding pocket [chemical binding]; other site 1205910011040 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1205910011041 nudix motif; other site 1205910011042 TROVE domain; Region: TROVE; pfam05731 1205910011043 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1205910011044 metal ion-dependent adhesion site (MIDAS); other site 1205910011045 Phosphotransferase enzyme family; Region: APH; pfam01636 1205910011046 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1205910011047 substrate binding site [chemical binding]; other site 1205910011048 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1205910011049 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1205910011050 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205910011051 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 1205910011052 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1205910011053 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1205910011054 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205910011055 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1205910011056 DNA-binding site [nucleotide binding]; DNA binding site 1205910011057 FCD domain; Region: FCD; pfam07729 1205910011058 tricarballylate dehydrogenase; Validated; Region: PRK08274 1205910011059 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1205910011060 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1205910011061 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1205910011062 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1205910011063 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910011064 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205910011065 Coenzyme A binding pocket [chemical binding]; other site 1205910011066 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1205910011067 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683 1205910011068 nudix motif; other site 1205910011069 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1205910011070 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205910011071 Coenzyme A binding pocket [chemical binding]; other site 1205910011072 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910011073 Walker A/P-loop; other site 1205910011074 ATP binding site [chemical binding]; other site 1205910011075 Q-loop/lid; other site 1205910011076 Predicted membrane protein [Function unknown]; Region: COG4125 1205910011077 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1205910011078 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1205910011079 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1205910011080 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1205910011081 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1205910011082 dimerization interface [polypeptide binding]; other site 1205910011083 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 1205910011084 active site 1205910011085 ATP binding site [chemical binding]; other site 1205910011086 Phosphotransferase enzyme family; Region: APH; pfam01636 1205910011087 antibiotic binding site [chemical binding]; other site 1205910011088 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1205910011089 Transposase; Region: HTH_Tnp_1; pfam01527 1205910011090 Integrase core domain; Region: rve; pfam00665 1205910011091 Integrase core domain; Region: rve_3; pfam13683 1205910011092 HTH domain; Region: HTH_11; pfam08279 1205910011093 WYL domain; Region: WYL; pfam13280 1205910011094 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1205910011095 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1205910011096 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 1205910011097 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205910011098 putative metal binding site [ion binding]; other site 1205910011099 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205910011100 dimerization interface [polypeptide binding]; other site 1205910011101 putative DNA binding site [nucleotide binding]; other site 1205910011102 putative Zn2+ binding site [ion binding]; other site 1205910011103 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1205910011104 arsenical-resistance protein; Region: acr3; TIGR00832 1205910011105 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1205910011106 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1205910011107 active site 1205910011108 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1205910011109 dimer interface [polypeptide binding]; other site 1205910011110 ADP-ribose binding site [chemical binding]; other site 1205910011111 active site 1205910011112 nudix motif; other site 1205910011113 metal binding site [ion binding]; metal-binding site 1205910011114 methyltransferase, FxLD system; Region: methyltran_FxLD; TIGR04364 1205910011115 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910011116 S-adenosylmethionine binding site [chemical binding]; other site 1205910011117 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 1205910011118 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 1205910011119 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 1205910011120 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1205910011121 active site 1205910011122 zinc binding site [ion binding]; other site 1205910011123 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1205910011124 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1205910011125 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1205910011126 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1205910011127 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1205910011128 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1205910011129 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910011130 non-specific DNA binding site [nucleotide binding]; other site 1205910011131 salt bridge; other site 1205910011132 sequence-specific DNA binding site [nucleotide binding]; other site 1205910011133 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1205910011134 DNA binding residues [nucleotide binding] 1205910011135 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1205910011136 Putative esterase; Region: Esterase; pfam00756 1205910011137 S-formylglutathione hydrolase; Region: PLN02442 1205910011138 SUKH-3 immunity protein; Region: SUKH-3; pfam14433 1205910011139 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1205910011140 RHS Repeat; Region: RHS_repeat; cl11982 1205910011141 RHS Repeat; Region: RHS_repeat; pfam05593 1205910011142 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1205910011143 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 1205910011144 Pretoxin HINT domain; Region: PT-HINT; pfam07591 1205910011145 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1205910011146 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1205910011147 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1205910011148 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1205910011149 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1205910011150 DNA binding residues [nucleotide binding] 1205910011151 dimer interface [polypeptide binding]; other site 1205910011152 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1205910011153 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1205910011154 Flavoprotein; Region: Flavoprotein; cl08021 1205910011155 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910011156 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910011157 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1205910011158 Amidase; Region: Amidase; pfam01425 1205910011159 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1205910011160 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1205910011161 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205910011162 DNA-binding site [nucleotide binding]; DNA binding site 1205910011163 FCD domain; Region: FCD; pfam07729 1205910011164 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 1205910011165 malonyl-CoA synthase; Validated; Region: PRK07514 1205910011166 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 1205910011167 acyl-activating enzyme (AAE) consensus motif; other site 1205910011168 active site 1205910011169 AMP binding site [chemical binding]; other site 1205910011170 CoA binding site [chemical binding]; other site 1205910011171 Malonate transporter MadL subunit; Region: MadL; cl04273 1205910011172 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 1205910011173 Phosphotransferase enzyme family; Region: APH; pfam01636 1205910011174 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1205910011175 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1205910011176 Phytase; Region: Phytase; cl17685 1205910011177 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1205910011178 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1205910011179 Predicted transcriptional regulators [Transcription]; Region: COG1733 1205910011180 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1205910011181 Phosphotransferase enzyme family; Region: APH; pfam01636 1205910011182 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1205910011183 substrate binding site [chemical binding]; other site 1205910011184 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1205910011185 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910011186 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910011187 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1205910011188 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910011189 Walker A/P-loop; other site 1205910011190 ATP binding site [chemical binding]; other site 1205910011191 Q-loop/lid; other site 1205910011192 ABC transporter signature motif; other site 1205910011193 Walker B; other site 1205910011194 D-loop; other site 1205910011195 H-loop/switch region; other site 1205910011196 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1205910011197 MarR family; Region: MarR_2; pfam12802 1205910011198 Predicted flavoprotein [General function prediction only]; Region: COG0431 1205910011199 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1205910011200 putative acetyltransferase; Provisional; Region: PRK03624 1205910011201 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205910011202 Coenzyme A binding pocket [chemical binding]; other site 1205910011203 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 1205910011204 Clp amino terminal domain; Region: Clp_N; pfam02861 1205910011205 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1205910011206 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205910011207 Coenzyme A binding pocket [chemical binding]; other site 1205910011208 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1205910011209 Peptidase family M23; Region: Peptidase_M23; pfam01551 1205910011210 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1205910011211 O-methyltransferase; Region: Methyltransf_2; pfam00891 1205910011212 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1205910011213 FMN binding site [chemical binding]; other site 1205910011214 dimer interface [polypeptide binding]; other site 1205910011215 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 1205910011216 O-methyltransferase; Region: Methyltransf_2; pfam00891 1205910011217 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1205910011218 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1205910011219 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1205910011220 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1205910011221 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1205910011222 carboxyltransferase (CT) interaction site; other site 1205910011223 biotinylation site [posttranslational modification]; other site 1205910011224 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 1205910011225 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 1205910011226 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910011227 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910011228 MMPL family; Region: MMPL; pfam03176 1205910011229 MMPL family; Region: MMPL; pfam03176 1205910011230 MarR family; Region: MarR_2; pfam12802 1205910011231 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1205910011232 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 1205910011233 putative ligand binding site [chemical binding]; other site 1205910011234 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1205910011235 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 1205910011236 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910011237 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910011238 NB-ARC domain; Region: NB-ARC; pfam00931 1205910011239 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1205910011240 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1205910011241 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1205910011242 active site 1205910011243 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1205910011244 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1205910011245 putative active site [active] 1205910011246 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1205910011247 Na binding site [ion binding]; other site 1205910011248 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1205910011249 MarR family; Region: MarR; pfam01047 1205910011250 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1205910011251 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910011252 Walker A/P-loop; other site 1205910011253 ATP binding site [chemical binding]; other site 1205910011254 Q-loop/lid; other site 1205910011255 ABC transporter signature motif; other site 1205910011256 Walker B; other site 1205910011257 D-loop; other site 1205910011258 H-loop/switch region; other site 1205910011259 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1205910011260 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1205910011261 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1205910011262 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1205910011263 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1205910011264 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1205910011265 tetrameric interface [polypeptide binding]; other site 1205910011266 NAD binding site [chemical binding]; other site 1205910011267 catalytic residues [active] 1205910011268 substrate binding site [chemical binding]; other site 1205910011269 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910011270 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910011271 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1205910011272 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205910011273 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1205910011274 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1205910011275 Q-loop/lid; other site 1205910011276 ABC transporter signature motif; other site 1205910011277 Walker B; other site 1205910011278 D-loop; other site 1205910011279 H-loop/switch region; other site 1205910011280 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1205910011281 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1205910011282 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1205910011283 Walker A/P-loop; other site 1205910011284 ATP binding site [chemical binding]; other site 1205910011285 Q-loop/lid; other site 1205910011286 ABC transporter signature motif; other site 1205910011287 Walker B; other site 1205910011288 D-loop; other site 1205910011289 H-loop/switch region; other site 1205910011290 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1205910011291 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1205910011292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910011293 dimer interface [polypeptide binding]; other site 1205910011294 conserved gate region; other site 1205910011295 putative PBP binding loops; other site 1205910011296 ABC-ATPase subunit interface; other site 1205910011297 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1205910011298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910011299 dimer interface [polypeptide binding]; other site 1205910011300 conserved gate region; other site 1205910011301 putative PBP binding loops; other site 1205910011302 ABC-ATPase subunit interface; other site 1205910011303 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1205910011304 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1205910011305 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 1205910011306 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1205910011307 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1205910011308 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1205910011309 putative active site [active] 1205910011310 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 1205910011311 Cupin domain; Region: Cupin_2; cl17218 1205910011312 Creatinine amidohydrolase; Region: Creatininase; pfam02633 1205910011313 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 1205910011314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910011315 S-adenosylmethionine binding site [chemical binding]; other site 1205910011316 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1205910011317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910011318 S-adenosylmethionine binding site [chemical binding]; other site 1205910011319 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1205910011320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910011321 putative substrate translocation pore; other site 1205910011322 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1205910011323 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1205910011324 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1205910011325 active site 1205910011326 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1205910011327 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 1205910011328 putative NAD(P) binding site [chemical binding]; other site 1205910011329 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1205910011330 dimerization interface [polypeptide binding]; other site 1205910011331 active site 1205910011332 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1205910011333 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205910011334 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205910011335 DNA binding residues [nucleotide binding] 1205910011336 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1205910011337 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1205910011338 Cu(I) binding site [ion binding]; other site 1205910011339 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1205910011340 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1205910011341 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1205910011342 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205910011343 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910011344 Walker A/P-loop; other site 1205910011345 ATP binding site [chemical binding]; other site 1205910011346 Q-loop/lid; other site 1205910011347 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1205910011348 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910011349 Walker A/P-loop; other site 1205910011350 ATP binding site [chemical binding]; other site 1205910011351 Q-loop/lid; other site 1205910011352 ABC transporter signature motif; other site 1205910011353 Walker B; other site 1205910011354 D-loop; other site 1205910011355 H-loop/switch region; other site 1205910011356 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1205910011357 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1205910011358 active site 1205910011359 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1205910011360 maltodextrin glucosidase; Provisional; Region: PRK10785 1205910011361 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1205910011362 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1205910011363 active site 1205910011364 homodimer interface [polypeptide binding]; other site 1205910011365 catalytic site [active] 1205910011366 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205910011367 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205910011368 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1205910011369 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205910011370 Coenzyme A binding pocket [chemical binding]; other site 1205910011371 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1205910011372 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1205910011373 cofactor binding site; other site 1205910011374 DNA binding site [nucleotide binding] 1205910011375 substrate interaction site [chemical binding]; other site 1205910011376 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1205910011377 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1205910011378 mismatch recognition site; other site 1205910011379 additional DNA contacts [nucleotide binding]; other site 1205910011380 active site 1205910011381 zinc binding site [ion binding]; other site 1205910011382 DNA intercalation site [nucleotide binding]; other site 1205910011383 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1205910011384 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1205910011385 active site 1205910011386 catalytic tetrad [active] 1205910011387 CGNR zinc finger; Region: zf-CGNR; pfam11706 1205910011388 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1205910011389 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1205910011390 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1205910011391 tetramer interface [polypeptide binding]; other site 1205910011392 active site 1205910011393 Mg2+/Mn2+ binding site [ion binding]; other site 1205910011394 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1205910011395 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1205910011396 S-adenosylmethionine binding site [chemical binding]; other site 1205910011397 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1205910011398 SNF2 Helicase protein; Region: DUF3670; pfam12419 1205910011399 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1205910011400 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205910011401 ATP binding site [chemical binding]; other site 1205910011402 putative Mg++ binding site [ion binding]; other site 1205910011403 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205910011404 nucleotide binding region [chemical binding]; other site 1205910011405 ATP-binding site [chemical binding]; other site 1205910011406 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 1205910011407 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910011408 putative substrate translocation pore; other site 1205910011409 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 1205910011410 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1205910011411 putative active site [active] 1205910011412 catalytic site [active] 1205910011413 putative metal binding site [ion binding]; other site 1205910011414 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1205910011415 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1205910011416 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1205910011417 NlpC/P60 family; Region: NLPC_P60; pfam00877 1205910011418 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1205910011419 active site 1205910011420 PBP superfamily domain; Region: PBP_like_2; cl17296 1205910011421 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 1205910011422 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1205910011423 active site 1205910011424 catalytic site [active] 1205910011425 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1205910011426 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910011427 S-adenosylmethionine binding site [chemical binding]; other site 1205910011428 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1205910011429 Predicted flavoprotein [General function prediction only]; Region: COG0431 1205910011430 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1205910011431 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1205910011432 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1205910011433 catalytic site [active] 1205910011434 active site 1205910011435 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1205910011436 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 1205910011437 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910011438 S-adenosylmethionine binding site [chemical binding]; other site 1205910011439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910011440 S-adenosylmethionine binding site [chemical binding]; other site 1205910011441 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 1205910011442 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 1205910011443 Phosphotransferase enzyme family; Region: APH; pfam01636 1205910011444 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1205910011445 active site 1205910011446 ATP binding site [chemical binding]; other site 1205910011447 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1205910011448 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205910011449 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910011450 active site 1205910011451 phosphorylation site [posttranslational modification] 1205910011452 intermolecular recognition site; other site 1205910011453 dimerization interface [polypeptide binding]; other site 1205910011454 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205910011455 DNA binding residues [nucleotide binding] 1205910011456 dimerization interface [polypeptide binding]; other site 1205910011457 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1205910011458 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1205910011459 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1205910011460 Histidine kinase; Region: HisKA_3; pfam07730 1205910011461 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910011462 ATP binding site [chemical binding]; other site 1205910011463 Mg2+ binding site [ion binding]; other site 1205910011464 G-X-G motif; other site 1205910011465 NACHT domain; Region: NACHT; pfam05729 1205910011466 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910011467 metabolite-proton symporter; Region: 2A0106; TIGR00883 1205910011468 putative substrate translocation pore; other site 1205910011469 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 1205910011470 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1205910011471 nudix motif; other site 1205910011472 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1205910011473 anti sigma factor interaction site; other site 1205910011474 regulatory phosphorylation site [posttranslational modification]; other site 1205910011475 Bacterial PH domain; Region: DUF304; pfam03703 1205910011476 Bacterial PH domain; Region: DUF304; pfam03703 1205910011477 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1205910011478 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 1205910011479 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1205910011480 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 1205910011481 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1205910011482 FAD binding domain; Region: FAD_binding_2; pfam00890 1205910011483 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1205910011484 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1205910011485 NAD binding site [chemical binding]; other site 1205910011486 catalytic Zn binding site [ion binding]; other site 1205910011487 substrate binding site [chemical binding]; other site 1205910011488 structural Zn binding site [ion binding]; other site 1205910011489 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1205910011490 Amidinotransferase; Region: Amidinotransf; cl12043 1205910011491 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910011492 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910011493 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1205910011494 agmatinase; Region: agmatinase; TIGR01230 1205910011495 oligomer interface [polypeptide binding]; other site 1205910011496 putative active site [active] 1205910011497 Mn binding site [ion binding]; other site 1205910011498 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1205910011499 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1205910011500 GAF domain; Region: GAF; cl17456 1205910011501 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1205910011502 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205910011503 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910011504 homodimer interface [polypeptide binding]; other site 1205910011505 catalytic residue [active] 1205910011506 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1205910011507 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1205910011508 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1205910011509 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1205910011510 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1205910011511 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1205910011512 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205910011513 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205910011514 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1205910011515 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1205910011516 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 1205910011517 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1205910011518 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1205910011519 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 1205910011520 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1205910011521 active site 1205910011522 putative substrate binding pocket [chemical binding]; other site 1205910011523 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1205910011524 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1205910011525 catalytic loop [active] 1205910011526 iron binding site [ion binding]; other site 1205910011527 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1205910011528 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 1205910011529 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1205910011530 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1205910011531 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1205910011532 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1205910011533 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1205910011534 BCCT family transporter; Region: BCCT; pfam02028 1205910011535 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205910011536 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1205910011537 DNA-binding site [nucleotide binding]; DNA binding site 1205910011538 FCD domain; Region: FCD; pfam07729 1205910011539 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1205910011540 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1205910011541 ATP binding site [chemical binding]; other site 1205910011542 Mg++ binding site [ion binding]; other site 1205910011543 motif III; other site 1205910011544 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205910011545 nucleotide binding region [chemical binding]; other site 1205910011546 ATP-binding site [chemical binding]; other site 1205910011547 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1205910011548 DNA-binding site [nucleotide binding]; DNA binding site 1205910011549 RNA-binding motif; other site 1205910011550 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205910011551 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1205910011552 NAD(P) binding site [chemical binding]; other site 1205910011553 active site 1205910011554 Cupin; Region: Cupin_6; pfam12852 1205910011555 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1205910011556 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1205910011557 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1205910011558 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; pfam04655 1205910011559 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 1205910011560 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205910011561 Cytochrome P450; Region: p450; cl12078 1205910011562 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205910011563 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205910011564 active site 1205910011565 ATP binding site [chemical binding]; other site 1205910011566 substrate binding site [chemical binding]; other site 1205910011567 activation loop (A-loop); other site 1205910011568 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1205910011569 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205910011570 DNA-binding site [nucleotide binding]; DNA binding site 1205910011571 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1205910011572 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1205910011573 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1205910011574 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1205910011575 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1205910011576 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205910011577 dimerization interface [polypeptide binding]; other site 1205910011578 putative DNA binding site [nucleotide binding]; other site 1205910011579 putative Zn2+ binding site [ion binding]; other site 1205910011580 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1205910011581 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1205910011582 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1205910011583 putative dimerization interface [polypeptide binding]; other site 1205910011584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910011585 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1205910011586 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1205910011587 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1205910011588 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205910011589 Zn binding site [ion binding]; other site 1205910011590 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1205910011591 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205910011592 Zn binding site [ion binding]; other site 1205910011593 Predicted esterase [General function prediction only]; Region: COG0400 1205910011594 hypothetical protein; Provisional; Region: PRK10621 1205910011595 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1205910011596 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1205910011597 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1205910011598 intersubunit interface [polypeptide binding]; other site 1205910011599 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1205910011600 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1205910011601 ABC-ATPase subunit interface; other site 1205910011602 dimer interface [polypeptide binding]; other site 1205910011603 putative PBP binding regions; other site 1205910011604 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1205910011605 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1205910011606 ABC-ATPase subunit interface; other site 1205910011607 dimer interface [polypeptide binding]; other site 1205910011608 putative PBP binding regions; other site 1205910011609 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1205910011610 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1205910011611 Walker A/P-loop; other site 1205910011612 ATP binding site [chemical binding]; other site 1205910011613 Q-loop/lid; other site 1205910011614 ABC transporter signature motif; other site 1205910011615 Walker B; other site 1205910011616 D-loop; other site 1205910011617 H-loop/switch region; other site 1205910011618 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205910011619 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1205910011620 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1205910011621 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1205910011622 G1 box; other site 1205910011623 GTP/Mg2+ binding site [chemical binding]; other site 1205910011624 G2 box; other site 1205910011625 Switch I region; other site 1205910011626 G3 box; other site 1205910011627 Switch II region; other site 1205910011628 G4 box; other site 1205910011629 G5 box; other site 1205910011630 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1205910011631 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 1205910011632 Nitrate and nitrite sensing; Region: NIT; pfam08376 1205910011633 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1205910011634 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910011635 ATP binding site [chemical binding]; other site 1205910011636 Mg2+ binding site [ion binding]; other site 1205910011637 G-X-G motif; other site 1205910011638 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1205910011639 aromatic arch; other site 1205910011640 DCoH dimer interaction site [polypeptide binding]; other site 1205910011641 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1205910011642 DCoH tetramer interaction site [polypeptide binding]; other site 1205910011643 substrate binding site [chemical binding]; other site 1205910011644 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1205910011645 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910011646 S-adenosylmethionine binding site [chemical binding]; other site 1205910011647 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 1205910011648 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1205910011649 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205910011650 acyl-activating enzyme (AAE) consensus motif; other site 1205910011651 AMP binding site [chemical binding]; other site 1205910011652 active site 1205910011653 CoA binding site [chemical binding]; other site 1205910011654 Phosphotransferase enzyme family; Region: APH; pfam01636 1205910011655 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1205910011656 substrate binding site [chemical binding]; other site 1205910011657 Acetokinase family; Region: Acetate_kinase; cl17229 1205910011658 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1205910011659 putative active site [active] 1205910011660 putative catalytic site [active] 1205910011661 putative DNA binding site [nucleotide binding]; other site 1205910011662 putative phosphate binding site [ion binding]; other site 1205910011663 metal binding site A [ion binding]; metal-binding site 1205910011664 putative AP binding site [nucleotide binding]; other site 1205910011665 putative metal binding site B [ion binding]; other site 1205910011666 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1205910011667 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205910011668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910011669 active site 1205910011670 phosphorylation site [posttranslational modification] 1205910011671 intermolecular recognition site; other site 1205910011672 dimerization interface [polypeptide binding]; other site 1205910011673 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205910011674 DNA binding residues [nucleotide binding] 1205910011675 dimerization interface [polypeptide binding]; other site 1205910011676 Histidine kinase; Region: HisKA_3; pfam07730 1205910011677 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1205910011678 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 1205910011679 DNA binding site [nucleotide binding] 1205910011680 dimer interface [polypeptide binding]; other site 1205910011681 active site 1205910011682 Int/Topo IB signature motif; other site 1205910011683 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 1205910011684 RNase_H superfamily; Region: RNase_H_2; pfam13482 1205910011685 AAA domain; Region: AAA_30; pfam13604 1205910011686 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1205910011687 AAA domain; Region: AAA_12; pfam13087 1205910011688 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1205910011689 active site 1205910011690 catalytic residues [active] 1205910011691 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1205910011692 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1205910011693 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1205910011694 DNA binding residues [nucleotide binding] 1205910011695 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1205910011696 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1205910011697 putative NAD(P) binding site [chemical binding]; other site 1205910011698 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 1205910011699 ligand binding site [chemical binding]; other site 1205910011700 Predicted acetyltransferase [General function prediction only]; Region: COG3153 1205910011701 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1205910011702 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1205910011703 active site 1205910011704 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1205910011705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910011706 S-adenosylmethionine binding site [chemical binding]; other site 1205910011707 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1205910011708 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1205910011709 active site 1205910011710 metal binding site [ion binding]; metal-binding site 1205910011711 hexamer interface [polypeptide binding]; other site 1205910011712 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1205910011713 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 1205910011714 putative NAD(P) binding site [chemical binding]; other site 1205910011715 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910011716 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910011717 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1205910011718 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1205910011719 dimer interface [polypeptide binding]; other site 1205910011720 putative PBP binding regions; other site 1205910011721 ABC-ATPase subunit interface; other site 1205910011722 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1205910011723 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1205910011724 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1205910011725 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1205910011726 metal binding site [ion binding]; metal-binding site 1205910011727 Predicted transcriptional regulators [Transcription]; Region: COG1510 1205910011728 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205910011729 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1205910011730 catalytic site [active] 1205910011731 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 1205910011732 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1205910011733 active site 1205910011734 catalytic site [active] 1205910011735 substrate binding site [chemical binding]; other site 1205910011736 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1205910011737 Dimer interface [polypeptide binding]; other site 1205910011738 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1205910011739 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205910011740 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910011741 active site 1205910011742 phosphorylation site [posttranslational modification] 1205910011743 intermolecular recognition site; other site 1205910011744 dimerization interface [polypeptide binding]; other site 1205910011745 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205910011746 DNA binding residues [nucleotide binding] 1205910011747 dimerization interface [polypeptide binding]; other site 1205910011748 Histidine kinase; Region: HisKA_3; pfam07730 1205910011749 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1205910011750 ATP binding site [chemical binding]; other site 1205910011751 Mg2+ binding site [ion binding]; other site 1205910011752 G-X-G motif; other site 1205910011753 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1205910011754 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910011755 Walker A/P-loop; other site 1205910011756 ATP binding site [chemical binding]; other site 1205910011757 Q-loop/lid; other site 1205910011758 ABC transporter signature motif; other site 1205910011759 Walker B; other site 1205910011760 D-loop; other site 1205910011761 H-loop/switch region; other site 1205910011762 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205910011763 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1205910011764 H+ Antiporter protein; Region: 2A0121; TIGR00900 1205910011765 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910011766 putative substrate translocation pore; other site 1205910011767 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1205910011768 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1205910011769 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1205910011770 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205910011771 TAP-like protein; Region: Abhydrolase_4; pfam08386 1205910011772 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910011773 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1205910011774 PhoD-like phosphatase; Region: PhoD; pfam09423 1205910011775 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1205910011776 putative active site [active] 1205910011777 putative metal binding site [ion binding]; other site 1205910011778 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1205910011779 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1205910011780 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1205910011781 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1205910011782 FeoA domain; Region: FeoA; pfam04023 1205910011783 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910011784 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910011785 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1205910011786 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1205910011787 glutamine binding [chemical binding]; other site 1205910011788 catalytic triad [active] 1205910011789 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1205910011790 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1205910011791 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1205910011792 Short C-terminal domain; Region: SHOCT; pfam09851 1205910011793 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910011794 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1205910011795 Walker A/P-loop; other site 1205910011796 ATP binding site [chemical binding]; other site 1205910011797 Q-loop/lid; other site 1205910011798 ABC transporter signature motif; other site 1205910011799 Walker B; other site 1205910011800 D-loop; other site 1205910011801 H-loop/switch region; other site 1205910011802 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1205910011803 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1205910011804 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1205910011805 active site 1205910011806 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1205910011807 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910011808 putative substrate translocation pore; other site 1205910011809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910011810 biotin synthase; Validated; Region: PRK06256 1205910011811 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205910011812 FeS/SAM binding site; other site 1205910011813 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1205910011814 yiaA/B two helix domain; Region: YiaAB; pfam05360 1205910011815 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1205910011816 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1205910011817 Amidinotransferase; Region: Amidinotransf; cl12043 1205910011818 CGNR zinc finger; Region: zf-CGNR; pfam11706 1205910011819 HTH domain; Region: HTH_11; pfam08279 1205910011820 WYL domain; Region: WYL; pfam13280 1205910011821 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 1205910011822 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1205910011823 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1205910011824 YCII-related domain; Region: YCII; cl00999 1205910011825 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1205910011826 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1205910011827 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205910011828 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910011829 active site 1205910011830 phosphorylation site [posttranslational modification] 1205910011831 intermolecular recognition site; other site 1205910011832 dimerization interface [polypeptide binding]; other site 1205910011833 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205910011834 DNA binding residues [nucleotide binding] 1205910011835 dimerization interface [polypeptide binding]; other site 1205910011836 Histidine kinase; Region: HisKA_3; pfam07730 1205910011837 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910011838 ATP binding site [chemical binding]; other site 1205910011839 Mg2+ binding site [ion binding]; other site 1205910011840 G-X-G motif; other site 1205910011841 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 1205910011842 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1205910011843 Helix-turn-helix domain; Region: HTH_17; pfam12728 1205910011844 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1205910011845 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1205910011846 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1205910011847 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205910011848 Coenzyme A binding pocket [chemical binding]; other site 1205910011849 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910011850 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910011851 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1205910011852 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1205910011853 Putative sensor; Region: Sensor; pfam13796 1205910011854 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1205910011855 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1205910011856 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910011857 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1205910011858 Walker A/P-loop; other site 1205910011859 ATP binding site [chemical binding]; other site 1205910011860 Q-loop/lid; other site 1205910011861 ABC transporter signature motif; other site 1205910011862 Walker B; other site 1205910011863 D-loop; other site 1205910011864 H-loop/switch region; other site 1205910011865 maltose O-acetyltransferase; Provisional; Region: PRK10092 1205910011866 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1205910011867 active site 1205910011868 substrate binding site [chemical binding]; other site 1205910011869 trimer interface [polypeptide binding]; other site 1205910011870 CoA binding site [chemical binding]; other site 1205910011871 short chain dehydrogenase; Provisional; Region: PRK08219 1205910011872 classical (c) SDRs; Region: SDR_c; cd05233 1205910011873 NAD(P) binding site [chemical binding]; other site 1205910011874 active site 1205910011875 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1205910011876 hypothetical protein; Provisional; Region: PRK07236 1205910011877 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1205910011878 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910011879 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910011880 camphor resistance protein CrcB; Provisional; Region: PRK14195 1205910011881 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1205910011882 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1205910011883 Integrase core domain; Region: rve; pfam00665 1205910011884 Integrase core domain; Region: rve_3; pfam13683 1205910011885 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1205910011886 Transposase; Region: HTH_Tnp_1; pfam01527 1205910011887 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1205910011888 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1205910011889 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1205910011890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910011891 S-adenosylmethionine binding site [chemical binding]; other site 1205910011892 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1205910011893 classical (c) SDRs; Region: SDR_c; cd05233 1205910011894 NAD(P) binding site [chemical binding]; other site 1205910011895 active site 1205910011896 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1205910011897 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910011898 Walker A/P-loop; other site 1205910011899 ATP binding site [chemical binding]; other site 1205910011900 Q-loop/lid; other site 1205910011901 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1205910011902 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910011903 Walker A/P-loop; other site 1205910011904 ATP binding site [chemical binding]; other site 1205910011905 Q-loop/lid; other site 1205910011906 ABC transporter; Region: ABC_tran; pfam00005 1205910011907 ABC transporter signature motif; other site 1205910011908 Walker B; other site 1205910011909 D-loop; other site 1205910011910 H-loop/switch region; other site 1205910011911 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910011912 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910011913 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1205910011914 Phosphotransferase enzyme family; Region: APH; pfam01636 1205910011915 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910011916 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910011917 WHG domain; Region: WHG; pfam13305 1205910011918 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844 1205910011919 active site 1205910011920 catalytic triad [active] 1205910011921 oxyanion hole [active] 1205910011922 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1205910011923 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1205910011924 DNA binding residues [nucleotide binding] 1205910011925 dimer interface [polypeptide binding]; other site 1205910011926 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910011927 S-adenosylmethionine binding site [chemical binding]; other site 1205910011928 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1205910011929 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1205910011930 DinB superfamily; Region: DinB_2; pfam12867 1205910011931 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1205910011932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910011933 glutamate dehydrogenase; Provisional; Region: PRK09414 1205910011934 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1205910011935 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1205910011936 NAD(P) binding site [chemical binding]; other site 1205910011937 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205910011938 active site 1205910011939 CoA binding site [chemical binding]; other site 1205910011940 AMP binding site [chemical binding]; other site 1205910011941 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205910011942 thioester reductase domain; Region: Thioester-redct; TIGR01746 1205910011943 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1205910011944 putative NAD(P) binding site [chemical binding]; other site 1205910011945 active site 1205910011946 putative substrate binding site [chemical binding]; other site 1205910011947 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1205910011948 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1205910011949 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910011950 non-specific DNA binding site [nucleotide binding]; other site 1205910011951 salt bridge; other site 1205910011952 sequence-specific DNA binding site [nucleotide binding]; other site 1205910011953 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1205910011954 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1205910011955 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1205910011956 EamA-like transporter family; Region: EamA; pfam00892 1205910011957 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1205910011958 ribonuclease Z; Reviewed; Region: PRK00055 1205910011959 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1205910011960 Pirin-related protein [General function prediction only]; Region: COG1741 1205910011961 Pirin; Region: Pirin; pfam02678 1205910011962 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1205910011963 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 1205910011964 Na2 binding site [ion binding]; other site 1205910011965 putative substrate binding site 1 [chemical binding]; other site 1205910011966 Na binding site 1 [ion binding]; other site 1205910011967 putative substrate binding site 2 [chemical binding]; other site 1205910011968 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1205910011969 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1205910011970 proposed catalytic triad [active] 1205910011971 conserved cys residue [active] 1205910011972 First Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt1; cd04772 1205910011973 DNA binding residues [nucleotide binding] 1205910011974 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1205910011975 putative dimer interface [polypeptide binding]; other site 1205910011976 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1205910011977 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1205910011978 DNA binding residues [nucleotide binding] 1205910011979 FAD binding domain; Region: FAD_binding_4; pfam01565 1205910011980 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1205910011981 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205910011982 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1205910011983 NAD(P) binding site [chemical binding]; other site 1205910011984 active site 1205910011985 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910011986 putative substrate translocation pore; other site 1205910011987 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910011988 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1205910011989 Walker A/P-loop; other site 1205910011990 ATP binding site [chemical binding]; other site 1205910011991 Q-loop/lid; other site 1205910011992 ABC transporter signature motif; other site 1205910011993 Walker B; other site 1205910011994 D-loop; other site 1205910011995 H-loop/switch region; other site 1205910011996 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1205910011997 short chain dehydrogenase; Provisional; Region: PRK06172 1205910011998 classical (c) SDRs; Region: SDR_c; cd05233 1205910011999 NAD(P) binding site [chemical binding]; other site 1205910012000 active site 1205910012001 MOSC domain; Region: MOSC; pfam03473 1205910012002 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 1205910012003 dimer interface [polypeptide binding]; other site 1205910012004 ligand binding site [chemical binding]; other site 1205910012005 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1205910012006 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910012007 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910012008 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1205910012009 conserved cys residue [active] 1205910012010 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1205910012011 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1205910012012 conserved cys residue [active] 1205910012013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910012014 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1205910012015 putative substrate translocation pore; other site 1205910012016 Predicted transcriptional regulators [Transcription]; Region: ArsR; COG0640 1205910012017 dimerization interface [polypeptide binding]; other site 1205910012018 putative DNA binding site [nucleotide binding]; other site 1205910012019 putative Zn2+ binding site [ion binding]; other site 1205910012020 Part of AAA domain; Region: AAA_19; pfam13245 1205910012021 Family description; Region: UvrD_C_2; pfam13538 1205910012022 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1205910012023 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1205910012024 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1205910012025 active site 1205910012026 potential frameshift: common BLAST hit: gi|297560845|ref|YP_003679819.1| ECF subfamily RNA polymerase sigma-24 subunit 1205910012027 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1205910012028 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205910012029 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1205910012030 Phosphotransferase enzyme family; Region: APH; pfam01636 1205910012031 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1205910012032 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1205910012033 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1205910012034 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1205910012035 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1205910012036 Protein of unknown function (DUF418); Region: DUF418; cl12135 1205910012037 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1205910012038 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1205910012039 DNA-binding interface [nucleotide binding]; DNA binding site 1205910012040 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1205910012041 MarR family; Region: MarR; pfam01047 1205910012042 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1205910012043 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1205910012044 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1205910012045 active site 1205910012046 metal binding site [ion binding]; metal-binding site 1205910012047 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1205910012048 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1205910012049 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1205910012050 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1205910012051 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205910012052 catalytic residue [active] 1205910012053 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1205910012054 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1205910012055 catalytic residues [active] 1205910012056 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1205910012057 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1205910012058 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1205910012059 active site 1205910012060 purine riboside binding site [chemical binding]; other site 1205910012061 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1205910012062 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 1205910012063 DNA binding residues [nucleotide binding] 1205910012064 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1205910012065 RNA/DNA hybrid binding site [nucleotide binding]; other site 1205910012066 active site 1205910012067 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1205910012068 active site 1205910012069 catalytic residues [active] 1205910012070 metal binding site [ion binding]; metal-binding site 1205910012071 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1205910012072 Putative sensor; Region: Sensor; pfam13796 1205910012073 Histidine kinase; Region: HisKA_3; pfam07730 1205910012074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910012075 ATP binding site [chemical binding]; other site 1205910012076 Mg2+ binding site [ion binding]; other site 1205910012077 G-X-G motif; other site 1205910012078 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205910012079 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205910012080 DNA binding residues [nucleotide binding] 1205910012081 dimerization interface [polypeptide binding]; other site 1205910012082 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205910012083 acyl-activating enzyme (AAE) consensus motif; other site 1205910012084 active site 1205910012085 AMP binding site [chemical binding]; other site 1205910012086 CoA binding site [chemical binding]; other site 1205910012087 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205910012088 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910012089 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1205910012090 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 1205910012091 MoxR-like ATPases [General function prediction only]; Region: COG0714 1205910012092 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205910012093 Walker A motif; other site 1205910012094 ATP binding site [chemical binding]; other site 1205910012095 Walker B motif; other site 1205910012096 arginine finger; other site 1205910012097 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1205910012098 Protein of unknown function DUF58; Region: DUF58; pfam01882 1205910012099 hypothetical protein; Provisional; Region: PRK13685 1205910012100 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1205910012101 metal ion-dependent adhesion site (MIDAS); other site 1205910012102 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1205910012103 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205910012104 motif II; other site 1205910012105 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 1205910012106 nudix motif; other site 1205910012107 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1205910012108 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 1205910012109 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 1205910012110 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910012111 S-adenosylmethionine binding site [chemical binding]; other site 1205910012112 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1205910012113 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1205910012114 Domain of unknown function DUF21; Region: DUF21; pfam01595 1205910012115 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1205910012116 Transporter associated domain; Region: CorC_HlyC; smart01091 1205910012117 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1205910012118 Domain of unknown function DUF21; Region: DUF21; pfam01595 1205910012119 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1205910012120 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910012121 S-adenosylmethionine binding site [chemical binding]; other site 1205910012122 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1205910012123 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1205910012124 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910012125 non-specific DNA binding site [nucleotide binding]; other site 1205910012126 salt bridge; other site 1205910012127 sequence-specific DNA binding site [nucleotide binding]; other site 1205910012128 Cupin domain; Region: Cupin_2; pfam07883 1205910012129 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205910012130 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1205910012131 DNA-binding site [nucleotide binding]; DNA binding site 1205910012132 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205910012133 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910012134 homodimer interface [polypeptide binding]; other site 1205910012135 catalytic residue [active] 1205910012136 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1205910012137 EamA-like transporter family; Region: EamA; pfam00892 1205910012138 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1205910012139 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1205910012140 MarR family; Region: MarR; pfam01047 1205910012141 succinylglutamic semialdehyde dehydrogenase; Region: arg_catab_astD; TIGR03240 1205910012142 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1205910012143 tetrameric interface [polypeptide binding]; other site 1205910012144 NAD binding site [chemical binding]; other site 1205910012145 catalytic residues [active] 1205910012146 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 1205910012147 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1205910012148 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 1205910012149 NodB motif; other site 1205910012150 active site 1205910012151 catalytic site [active] 1205910012152 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1205910012153 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 1205910012154 NodB motif; other site 1205910012155 active site 1205910012156 catalytic site [active] 1205910012157 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1205910012158 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 1205910012159 NAD(P) binding site [chemical binding]; other site 1205910012160 catalytic residues [active] 1205910012161 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910012162 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910012163 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1205910012164 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205910012165 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1205910012166 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205910012167 dimerization interface [polypeptide binding]; other site 1205910012168 putative DNA binding site [nucleotide binding]; other site 1205910012169 putative Zn2+ binding site [ion binding]; other site 1205910012170 CGNR zinc finger; Region: zf-CGNR; pfam11706 1205910012171 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1205910012172 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1205910012173 Phosphotransferase enzyme family; Region: APH; pfam01636 1205910012174 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1205910012175 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 1205910012176 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1205910012177 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1205910012178 nudix motif; other site 1205910012179 Domain of unknown function (DUF336); Region: DUF336; pfam03928 1205910012180 RibD C-terminal domain; Region: RibD_C; cl17279 1205910012181 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1205910012182 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1205910012183 ligand binding site [chemical binding]; other site 1205910012184 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1205910012185 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1205910012186 Cupin domain; Region: Cupin_2; cl17218 1205910012187 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1205910012188 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1205910012189 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910012190 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1205910012191 putative substrate translocation pore; other site 1205910012192 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1205910012193 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1205910012194 glutaminase; Provisional; Region: PRK00971 1205910012195 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1205910012196 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910012197 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910012198 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1205910012199 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1205910012200 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205910012201 NAD(P) binding site [chemical binding]; other site 1205910012202 active site 1205910012203 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1205910012204 putative active site [active] 1205910012205 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1205910012206 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1205910012207 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205910012208 DNA-binding site [nucleotide binding]; DNA binding site 1205910012209 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1205910012210 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1205910012211 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1205910012212 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1205910012213 active site 1205910012214 NodB motif; other site 1205910012215 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 1205910012216 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1205910012217 DDE superfamily endonuclease; Region: DDE_4; pfam13359 1205910012218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910012219 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1205910012220 putative substrate translocation pore; other site 1205910012221 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910012222 S-adenosylmethionine binding site [chemical binding]; other site 1205910012223 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1205910012224 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1205910012225 active site 1205910012226 catalytic tetrad [active] 1205910012227 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205910012228 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910012229 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1205910012230 salt bridge; other site 1205910012231 non-specific DNA binding site [nucleotide binding]; other site 1205910012232 sequence-specific DNA binding site [nucleotide binding]; other site 1205910012233 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 1205910012234 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1205910012235 catalytic Zn binding site [ion binding]; other site 1205910012236 NAD(P) binding site [chemical binding]; other site 1205910012237 structural Zn binding site [ion binding]; other site 1205910012238 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205910012239 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1205910012240 DNA-binding site [nucleotide binding]; DNA binding site 1205910012241 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1205910012242 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326 1205910012243 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1205910012244 putative active site pocket [active] 1205910012245 metal binding site [ion binding]; metal-binding site 1205910012246 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1205910012247 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1205910012248 transmembrane helices; other site 1205910012249 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1205910012250 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1205910012251 DNA binding residues [nucleotide binding] 1205910012252 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; pfam04655 1205910012253 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1205910012254 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910012255 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910012256 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1205910012257 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1205910012258 Walker A/P-loop; other site 1205910012259 ATP binding site [chemical binding]; other site 1205910012260 Q-loop/lid; other site 1205910012261 ABC transporter signature motif; other site 1205910012262 Walker B; other site 1205910012263 D-loop; other site 1205910012264 H-loop/switch region; other site 1205910012265 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1205910012266 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1205910012267 FtsX-like permease family; Region: FtsX; pfam02687 1205910012268 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910012269 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910012270 MMPL family; Region: MMPL; pfam03176 1205910012271 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 1205910012272 MMPL family; Region: MMPL; pfam03176 1205910012273 H+ Antiporter protein; Region: 2A0121; TIGR00900 1205910012274 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910012275 putative substrate translocation pore; other site 1205910012276 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1205910012277 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1205910012278 binding surface 1205910012279 TPR motif; other site 1205910012280 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1205910012281 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1205910012282 binding surface 1205910012283 TPR motif; other site 1205910012284 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1205910012285 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1205910012286 binding surface 1205910012287 TPR motif; other site 1205910012288 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1205910012289 The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators; Region: NR_LBD; cl11397 1205910012290 coregulator recognition site; other site 1205910012291 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1205910012292 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205910012293 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205910012294 DNA binding residues [nucleotide binding] 1205910012295 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1205910012296 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1205910012297 putative NAD(P) binding site [chemical binding]; other site 1205910012298 H+ Antiporter protein; Region: 2A0121; TIGR00900 1205910012299 S-formylglutathione hydrolase; Region: PLN02442 1205910012300 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910012301 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1205910012302 binding surface 1205910012303 TPR motif; other site 1205910012304 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1205910012305 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1205910012306 binding surface 1205910012307 TPR motif; other site 1205910012308 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1205910012309 binding surface 1205910012310 TPR motif; other site 1205910012311 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 1205910012312 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1205910012313 NAD(P) binding site [chemical binding]; other site 1205910012314 active site 1205910012315 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 1205910012316 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1205910012317 S-adenosylmethionine binding site [chemical binding]; other site 1205910012318 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 1205910012319 Carboxylesterase family; Region: COesterase; pfam00135 1205910012320 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1205910012321 substrate binding pocket [chemical binding]; other site 1205910012322 catalytic triad [active] 1205910012323 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1205910012324 active site 1205910012325 substrate binding site [chemical binding]; other site 1205910012326 ATP binding site [chemical binding]; other site 1205910012327 Phosphotransferase enzyme family; Region: APH; pfam01636 1205910012328 PGAP1-like protein; Region: PGAP1; pfam07819 1205910012329 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1205910012330 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910012331 Walker A/P-loop; other site 1205910012332 ATP binding site [chemical binding]; other site 1205910012333 Q-loop/lid; other site 1205910012334 ABC transporter; Region: ABC_tran_2; pfam12848 1205910012335 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1205910012336 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1205910012337 metal binding site [ion binding]; metal-binding site 1205910012338 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 1205910012339 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205910012340 non-specific DNA binding site [nucleotide binding]; other site 1205910012341 salt bridge; other site 1205910012342 sequence-specific DNA binding site [nucleotide binding]; other site 1205910012343 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 1205910012344 NB-ARC domain; Region: NB-ARC; pfam00931 1205910012345 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1205910012346 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1205910012347 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1205910012348 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1205910012349 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1205910012350 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205910012351 NAD(P) binding site [chemical binding]; other site 1205910012352 active site 1205910012353 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 1205910012354 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1205910012355 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1205910012356 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1205910012357 active site 1205910012358 catalytic tetrad [active] 1205910012359 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1205910012360 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1205910012361 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1205910012362 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 1205910012363 putative active site [active] 1205910012364 putative FMN binding site [chemical binding]; other site 1205910012365 putative substrate binding site [chemical binding]; other site 1205910012366 putative catalytic residue [active] 1205910012367 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910012368 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910012369 WHG domain; Region: WHG; pfam13305 1205910012370 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1205910012371 putative active site [active] 1205910012372 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1205910012373 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 1205910012374 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1205910012375 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1205910012376 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1205910012377 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1205910012378 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1205910012379 FAD binding domain; Region: FAD_binding_4; pfam01565 1205910012380 Berberine and berberine like; Region: BBE; pfam08031 1205910012381 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1205910012382 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1205910012383 active site 1205910012384 catalytic tetrad [active] 1205910012385 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1205910012386 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1205910012387 active site 1205910012388 catalytic site [active] 1205910012389 substrate binding site [chemical binding]; other site 1205910012390 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1205910012391 active site 1205910012392 catalytic residues [active] 1205910012393 Predicted transcriptional regulators [Transcription]; Region: COG1733 1205910012394 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205910012395 dimerization interface [polypeptide binding]; other site 1205910012396 putative DNA binding site [nucleotide binding]; other site 1205910012397 putative Zn2+ binding site [ion binding]; other site 1205910012398 VanZ like family; Region: VanZ; pfam04892 1205910012399 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 1205910012400 ADP-ribose binding site [chemical binding]; other site 1205910012401 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910012402 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 1205910012403 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1205910012404 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205910012405 motif II; other site 1205910012406 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1205910012407 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1205910012408 DNA binding residues [nucleotide binding] 1205910012409 short chain dehydrogenase; Validated; Region: PRK08264 1205910012410 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205910012411 NAD(P) binding site [chemical binding]; other site 1205910012412 active site 1205910012413 HEAT repeats; Region: HEAT_2; pfam13646 1205910012414 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205910012415 catalytic core [active] 1205910012416 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1205910012417 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1205910012418 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910012419 S-adenosylmethionine binding site [chemical binding]; other site 1205910012420 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910012421 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910012422 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 1205910012423 putative DNA binding helix; other site 1205910012424 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205910012425 Coenzyme A binding pocket [chemical binding]; other site 1205910012426 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1205910012427 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1205910012428 Peptidase family M23; Region: Peptidase_M23; pfam01551 1205910012429 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1205910012430 Predicted ATPase [General function prediction only]; Region: COG3903 1205910012431 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 1205910012432 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1205910012433 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1205910012434 catalytic site [active] 1205910012435 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1205910012436 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1205910012437 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1205910012438 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1205910012439 putative NAD(P) binding site [chemical binding]; other site 1205910012440 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1205910012441 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1205910012442 Phosphotransferase enzyme family; Region: APH; pfam01636 1205910012443 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1205910012444 active site 1205910012445 ATP binding site [chemical binding]; other site 1205910012446 substrate binding site [chemical binding]; other site 1205910012447 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 1205910012448 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1205910012449 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1205910012450 DNA binding residues [nucleotide binding] 1205910012451 drug binding residues [chemical binding]; other site 1205910012452 dimer interface [polypeptide binding]; other site 1205910012453 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1205910012454 fumarylacetoacetase; Region: PLN02856 1205910012455 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 1205910012456 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1205910012457 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 1205910012458 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 1205910012459 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1205910012460 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1205910012461 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1205910012462 MarR family; Region: MarR; pfam01047 1205910012463 H+ Antiporter protein; Region: 2A0121; TIGR00900 1205910012464 Phosphotransferase enzyme family; Region: APH; pfam01636 1205910012465 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1205910012466 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1205910012467 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1205910012468 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205910012469 catalytic residue [active] 1205910012470 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1205910012471 hypothetical protein; Provisional; Region: PRK01346 1205910012472 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1205910012473 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 1205910012474 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1205910012475 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1205910012476 FAD binding pocket [chemical binding]; other site 1205910012477 FAD binding motif [chemical binding]; other site 1205910012478 phosphate binding motif [ion binding]; other site 1205910012479 NAD binding pocket [chemical binding]; other site 1205910012480 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1205910012481 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205910012482 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205910012483 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1205910012484 Predicted membrane protein [Function unknown]; Region: COG2860 1205910012485 UPF0126 domain; Region: UPF0126; pfam03458 1205910012486 UPF0126 domain; Region: UPF0126; pfam03458 1205910012487 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205910012488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910012489 active site 1205910012490 phosphorylation site [posttranslational modification] 1205910012491 intermolecular recognition site; other site 1205910012492 dimerization interface [polypeptide binding]; other site 1205910012493 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205910012494 DNA binding residues [nucleotide binding] 1205910012495 dimerization interface [polypeptide binding]; other site 1205910012496 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1205910012497 active site 1205910012498 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1205910012499 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1205910012500 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1205910012501 putative dimerization interface [polypeptide binding]; other site 1205910012502 threonine dehydratase; Provisional; Region: PRK08246 1205910012503 hypothetical protein; Provisional; Region: PRK06815 1205910012504 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205910012505 catalytic residue [active] 1205910012506 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1205910012507 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1205910012508 putative acyl-acceptor binding pocket; other site 1205910012509 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain; Region: NAGLU; pfam05089 1205910012510 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972 1205910012511 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1205910012512 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1205910012513 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1205910012514 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1205910012515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910012516 dimer interface [polypeptide binding]; other site 1205910012517 conserved gate region; other site 1205910012518 putative PBP binding loops; other site 1205910012519 ABC-ATPase subunit interface; other site 1205910012520 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205910012521 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1205910012522 tartrate dehydrogenase; Region: TTC; TIGR02089 1205910012523 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1205910012524 transcriptional activator TtdR; Provisional; Region: PRK09801 1205910012525 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1205910012526 dimerization interface [polypeptide binding]; other site 1205910012527 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 1205910012528 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 1205910012529 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1205910012530 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1205910012531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1205910012532 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1205910012533 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910012534 Walker A/P-loop; other site 1205910012535 ATP binding site [chemical binding]; other site 1205910012536 Q-loop/lid; other site 1205910012537 ABC transporter signature motif; other site 1205910012538 Walker B; other site 1205910012539 D-loop; other site 1205910012540 H-loop/switch region; other site 1205910012541 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1205910012542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910012543 putative substrate translocation pore; other site 1205910012544 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1205910012545 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1205910012546 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1205910012547 dimerization interface [polypeptide binding]; other site 1205910012548 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1205910012549 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1205910012550 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1205910012551 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1205910012552 acyl-activating enzyme (AAE) consensus motif; other site 1205910012553 AMP binding site [chemical binding]; other site 1205910012554 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205910012555 Condensation domain; Region: Condensation; pfam00668 1205910012556 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1205910012557 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1205910012558 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205910012559 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205910012560 NAD(P) binding site [chemical binding]; other site 1205910012561 active site 1205910012562 substrate binding pocket [chemical binding]; other site 1205910012563 active site 1205910012564 iron coordination sites [ion binding]; other site 1205910012565 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1205910012566 classical (c) SDRs; Region: SDR_c; cd05233 1205910012567 NAD(P) binding site [chemical binding]; other site 1205910012568 active site 1205910012569 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1205910012570 ChaB; Region: ChaB; pfam06150 1205910012571 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 1205910012572 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 1205910012573 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205910012574 putative metal binding site [ion binding]; other site 1205910012575 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 1205910012576 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 1205910012577 homodimer interface [polypeptide binding]; other site 1205910012578 catalytic residues [active] 1205910012579 NAD binding site [chemical binding]; other site 1205910012580 substrate binding pocket [chemical binding]; other site 1205910012581 flexible flap; other site 1205910012582 GAF domain; Region: GAF_2; pfam13185 1205910012583 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1205910012584 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1205910012585 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1205910012586 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205910012587 DNA-binding site [nucleotide binding]; DNA binding site 1205910012588 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1205910012589 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 1205910012590 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1205910012591 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1205910012592 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1205910012593 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1205910012594 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1205910012595 intersubunit interface [polypeptide binding]; other site 1205910012596 active site 1205910012597 Zn2+ binding site [ion binding]; other site 1205910012598 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910012599 S-adenosylmethionine binding site [chemical binding]; other site 1205910012600 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1205910012601 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1205910012602 Na binding site [ion binding]; other site 1205910012603 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1205910012604 homotrimer interaction site [polypeptide binding]; other site 1205910012605 putative active site [active] 1205910012606 dihydroorotase; Provisional; Region: PRK09237 1205910012607 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1205910012608 active site 1205910012609 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1205910012610 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1205910012611 substrate binding site [chemical binding]; other site 1205910012612 ATP binding site [chemical binding]; other site 1205910012613 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1205910012614 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1205910012615 Bacterial transcriptional regulator; Region: IclR; pfam01614 1205910012616 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1205910012617 CGNR zinc finger; Region: zf-CGNR; pfam11706 1205910012618 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205910012619 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1205910012620 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1205910012621 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1205910012622 Walker A/P-loop; other site 1205910012623 ATP binding site [chemical binding]; other site 1205910012624 Q-loop/lid; other site 1205910012625 ABC transporter signature motif; other site 1205910012626 Walker B; other site 1205910012627 D-loop; other site 1205910012628 H-loop/switch region; other site 1205910012629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910012630 dimer interface [polypeptide binding]; other site 1205910012631 conserved gate region; other site 1205910012632 putative PBP binding loops; other site 1205910012633 ABC-ATPase subunit interface; other site 1205910012634 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910012635 dimer interface [polypeptide binding]; other site 1205910012636 conserved gate region; other site 1205910012637 putative PBP binding loops; other site 1205910012638 ABC-ATPase subunit interface; other site 1205910012639 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1205910012640 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1205910012641 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1205910012642 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1205910012643 DNA binding site [nucleotide binding] 1205910012644 domain linker motif; other site 1205910012645 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1205910012646 ligand binding site [chemical binding]; other site 1205910012647 dimerization interface [polypeptide binding]; other site 1205910012648 BCCT family transporter; Region: BCCT; pfam02028 1205910012649 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1205910012650 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1205910012651 proline aminopeptidase P II; Provisional; Region: PRK10879 1205910012652 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 1205910012653 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1205910012654 active site 1205910012655 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1205910012656 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205910012657 Coenzyme A binding pocket [chemical binding]; other site 1205910012658 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1205910012659 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205910012660 catalytic residue [active] 1205910012661 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1205910012662 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1205910012663 SnoaL-like domain; Region: SnoaL_2; pfam12680 1205910012664 Cupin domain; Region: Cupin_2; cl17218 1205910012665 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205910012666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910012667 active site 1205910012668 phosphorylation site [posttranslational modification] 1205910012669 intermolecular recognition site; other site 1205910012670 dimerization interface [polypeptide binding]; other site 1205910012671 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205910012672 DNA binding residues [nucleotide binding] 1205910012673 dimerization interface [polypeptide binding]; other site 1205910012674 Putative sensor; Region: Sensor; pfam13796 1205910012675 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1205910012676 Histidine kinase; Region: HisKA_3; pfam07730 1205910012677 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910012678 ATP binding site [chemical binding]; other site 1205910012679 Mg2+ binding site [ion binding]; other site 1205910012680 G-X-G motif; other site 1205910012681 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1205910012682 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1205910012683 tetramer interface [polypeptide binding]; other site 1205910012684 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1205910012685 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910012686 Walker A/P-loop; other site 1205910012687 ATP binding site [chemical binding]; other site 1205910012688 Q-loop/lid; other site 1205910012689 ABC transporter signature motif; other site 1205910012690 Walker B; other site 1205910012691 D-loop; other site 1205910012692 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1205910012693 dimerization interface [polypeptide binding]; other site 1205910012694 urea carboxylase; Region: urea_carbox; TIGR02712 1205910012695 short chain dehydrogenase; Provisional; Region: PRK06181 1205910012696 classical (c) SDRs; Region: SDR_c; cd05233 1205910012697 NAD(P) binding site [chemical binding]; other site 1205910012698 active site 1205910012699 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1205910012700 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1205910012701 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1205910012702 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 1205910012703 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205910012704 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1205910012705 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205910012706 DNA binding residues [nucleotide binding] 1205910012707 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1205910012708 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1205910012709 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1205910012710 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1205910012711 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1205910012712 molybdopterin cofactor binding site; other site 1205910012713 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 1205910012714 4Fe-4S binding domain; Region: Fer4; pfam00037 1205910012715 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1205910012716 thiamine pyrophosphate protein; Provisional; Region: PRK08273 1205910012717 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1205910012718 PYR/PP interface [polypeptide binding]; other site 1205910012719 dimer interface [polypeptide binding]; other site 1205910012720 tetramer interface [polypeptide binding]; other site 1205910012721 TPP binding site [chemical binding]; other site 1205910012722 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1205910012723 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1205910012724 TPP-binding site [chemical binding]; other site 1205910012725 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1205910012726 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1205910012727 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1205910012728 NAD(P) binding site [chemical binding]; other site 1205910012729 hydroperoxidase II; Provisional; Region: katE; PRK11249 1205910012730 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1205910012731 tetramer interface [polypeptide binding]; other site 1205910012732 heme binding pocket [chemical binding]; other site 1205910012733 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1205910012734 domain interactions; other site 1205910012735 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 1205910012736 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205910012737 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1205910012738 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205910012739 DNA binding residues [nucleotide binding] 1205910012740 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1205910012741 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1205910012742 tetramer interface [polypeptide binding]; other site 1205910012743 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205910012744 catalytic residue [active] 1205910012745 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1205910012746 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1205910012747 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1205910012748 intersubunit interface [polypeptide binding]; other site 1205910012749 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1205910012750 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1205910012751 ABC-ATPase subunit interface; other site 1205910012752 dimer interface [polypeptide binding]; other site 1205910012753 putative PBP binding regions; other site 1205910012754 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1205910012755 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1205910012756 dimer interface [polypeptide binding]; other site 1205910012757 ABC-ATPase subunit interface; other site 1205910012758 putative PBP binding regions; other site 1205910012759 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 1205910012760 DDE superfamily endonuclease; Region: DDE_4; cl17710 1205910012761 PQQ-like domain; Region: PQQ_2; pfam13360 1205910012762 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1205910012763 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1205910012764 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 1205910012765 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1205910012766 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1205910012767 Bacterial transcriptional regulator; Region: IclR; pfam01614 1205910012768 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1205910012769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910012770 dimer interface [polypeptide binding]; other site 1205910012771 conserved gate region; other site 1205910012772 putative PBP binding loops; other site 1205910012773 ABC-ATPase subunit interface; other site 1205910012774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910012775 dimer interface [polypeptide binding]; other site 1205910012776 conserved gate region; other site 1205910012777 putative PBP binding loops; other site 1205910012778 ABC-ATPase subunit interface; other site 1205910012779 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1205910012780 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1205910012781 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1205910012782 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 1205910012783 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1205910012784 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1205910012785 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1205910012786 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205910012787 active site 1205910012788 ATP binding site [chemical binding]; other site 1205910012789 substrate binding site [chemical binding]; other site 1205910012790 activation loop (A-loop); other site 1205910012791 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1205910012792 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205910012793 active site 1205910012794 ATP binding site [chemical binding]; other site 1205910012795 substrate binding site [chemical binding]; other site 1205910012796 activation loop (A-loop); other site 1205910012797 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1205910012798 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1205910012799 DNA binding site [nucleotide binding] 1205910012800 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1205910012801 ligand binding site [chemical binding]; other site 1205910012802 dimerization interface [polypeptide binding]; other site 1205910012803 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1205910012804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910012805 putative substrate translocation pore; other site 1205910012806 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1205910012807 CoenzymeA binding site [chemical binding]; other site 1205910012808 subunit interaction site [polypeptide binding]; other site 1205910012809 PHB binding site; other site 1205910012810 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1205910012811 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1205910012812 FAD binding pocket [chemical binding]; other site 1205910012813 FAD binding motif [chemical binding]; other site 1205910012814 phosphate binding motif [ion binding]; other site 1205910012815 beta-alpha-beta structure motif; other site 1205910012816 NAD(p) ribose binding residues [chemical binding]; other site 1205910012817 NAD binding pocket [chemical binding]; other site 1205910012818 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1205910012819 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1205910012820 catalytic loop [active] 1205910012821 iron binding site [ion binding]; other site 1205910012822 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1205910012823 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 1205910012824 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 1205910012825 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 1205910012826 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 1205910012827 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 1205910012828 enoyl-CoA hydratase; Provisional; Region: PRK06688 1205910012829 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205910012830 substrate binding site [chemical binding]; other site 1205910012831 oxyanion hole (OAH) forming residues; other site 1205910012832 trimer interface [polypeptide binding]; other site 1205910012833 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1205910012834 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1205910012835 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1205910012836 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1205910012837 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1205910012838 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205910012839 substrate binding site [chemical binding]; other site 1205910012840 oxyanion hole (OAH) forming residues; other site 1205910012841 trimer interface [polypeptide binding]; other site 1205910012842 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1205910012843 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1205910012844 dimer interface [polypeptide binding]; other site 1205910012845 active site 1205910012846 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205910012847 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 1205910012848 acyl-activating enzyme (AAE) consensus motif; other site 1205910012849 AMP binding site [chemical binding]; other site 1205910012850 active site 1205910012851 CoA binding site [chemical binding]; other site 1205910012852 Cupin domain; Region: Cupin_2; cl17218 1205910012853 Helix-turn-helix domain; Region: HTH_18; pfam12833 1205910012854 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1205910012855 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1205910012856 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205910012857 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205910012858 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1205910012859 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1205910012860 active site 1205910012861 metabolite-proton symporter; Region: 2A0106; TIGR00883 1205910012862 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910012863 putative substrate translocation pore; other site 1205910012864 allantoate amidohydrolase; Reviewed; Region: PRK09290 1205910012865 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1205910012866 active site 1205910012867 metal binding site [ion binding]; metal-binding site 1205910012868 dimer interface [polypeptide binding]; other site 1205910012869 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 1205910012870 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1205910012871 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 1205910012872 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910012873 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1205910012874 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1205910012875 oligomer interface [polypeptide binding]; other site 1205910012876 metal binding site [ion binding]; metal-binding site 1205910012877 metal binding site [ion binding]; metal-binding site 1205910012878 putative Cl binding site [ion binding]; other site 1205910012879 basic sphincter; other site 1205910012880 hydrophobic gate; other site 1205910012881 periplasmic entrance; other site 1205910012882 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 1205910012883 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 1205910012884 EamA-like transporter family; Region: EamA; pfam00892 1205910012885 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1205910012886 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1205910012887 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1205910012888 putative dimerization interface [polypeptide binding]; other site 1205910012889 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1205910012890 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205910012891 putative DNA binding site [nucleotide binding]; other site 1205910012892 putative Zn2+ binding site [ion binding]; other site 1205910012893 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1205910012894 putative dimerization interface [polypeptide binding]; other site 1205910012895 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1205910012896 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205910012897 Coenzyme A binding pocket [chemical binding]; other site 1205910012898 Predicted membrane protein [Function unknown]; Region: COG1289 1205910012899 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1205910012900 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1205910012901 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1205910012902 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1205910012903 putative acyl-acceptor binding pocket; other site 1205910012904 ferredoxin-NADP+ reductase; Region: PLN02852 1205910012905 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205910012906 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1205910012907 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1205910012908 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1205910012909 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1205910012910 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910012911 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1205910012912 Walker A/P-loop; other site 1205910012913 ATP binding site [chemical binding]; other site 1205910012914 Q-loop/lid; other site 1205910012915 ABC transporter signature motif; other site 1205910012916 Walker B; other site 1205910012917 D-loop; other site 1205910012918 H-loop/switch region; other site 1205910012919 TOBE domain; Region: TOBE; cl01440 1205910012920 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1205910012921 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910012922 dimer interface [polypeptide binding]; other site 1205910012923 conserved gate region; other site 1205910012924 putative PBP binding loops; other site 1205910012925 ABC-ATPase subunit interface; other site 1205910012926 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1205910012927 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1205910012928 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1205910012929 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1205910012930 DNA binding residues [nucleotide binding] 1205910012931 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1205910012932 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1205910012933 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1205910012934 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1205910012935 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205910012936 Coenzyme A binding pocket [chemical binding]; other site 1205910012937 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 1205910012938 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1205910012939 nudix motif; other site 1205910012940 CAAX protease self-immunity; Region: Abi; pfam02517 1205910012941 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1205910012942 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1205910012943 dimer interface [polypeptide binding]; other site 1205910012944 tetramer interface [polypeptide binding]; other site 1205910012945 PYR/PP interface [polypeptide binding]; other site 1205910012946 TPP binding site [chemical binding]; other site 1205910012947 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1205910012948 TPP-binding site; other site 1205910012949 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1205910012950 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1205910012951 active site 1205910012952 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205910012953 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1205910012954 substrate binding site [chemical binding]; other site 1205910012955 oxyanion hole (OAH) forming residues; other site 1205910012956 trimer interface [polypeptide binding]; other site 1205910012957 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 1205910012958 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205910012959 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205910012960 acyl-activating enzyme (AAE) consensus motif; other site 1205910012961 acyl-activating enzyme (AAE) consensus motif; other site 1205910012962 AMP binding site [chemical binding]; other site 1205910012963 active site 1205910012964 CoA binding site [chemical binding]; other site 1205910012965 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1205910012966 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1205910012967 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205910012968 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1205910012969 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205910012970 DNA binding residues [nucleotide binding] 1205910012971 Predicted transcriptional regulators [Transcription]; Region: COG1725 1205910012972 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205910012973 DNA-binding site [nucleotide binding]; DNA binding site 1205910012974 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1205910012975 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1205910012976 ABC transporter signature motif; other site 1205910012977 Walker B; other site 1205910012978 D-loop; other site 1205910012979 H-loop/switch region; other site 1205910012980 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1205910012981 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1205910012982 Walker A/P-loop; other site 1205910012983 ATP binding site [chemical binding]; other site 1205910012984 Q-loop/lid; other site 1205910012985 ABC transporter signature motif; other site 1205910012986 Walker B; other site 1205910012987 D-loop; other site 1205910012988 H-loop/switch region; other site 1205910012989 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1205910012990 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1205910012991 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910012992 dimer interface [polypeptide binding]; other site 1205910012993 conserved gate region; other site 1205910012994 putative PBP binding loops; other site 1205910012995 ABC-ATPase subunit interface; other site 1205910012996 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1205910012997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910012998 putative PBP binding loops; other site 1205910012999 dimer interface [polypeptide binding]; other site 1205910013000 ABC-ATPase subunit interface; other site 1205910013001 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910013002 dimer interface [polypeptide binding]; other site 1205910013003 conserved gate region; other site 1205910013004 putative PBP binding loops; other site 1205910013005 ABC-ATPase subunit interface; other site 1205910013006 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1205910013007 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 1205910013008 putative NAD(P) binding site [chemical binding]; other site 1205910013009 catalytic Zn binding site [ion binding]; other site 1205910013010 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1205910013011 amidase catalytic site [active] 1205910013012 Zn binding residues [ion binding]; other site 1205910013013 substrate binding site [chemical binding]; other site 1205910013014 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 1205910013015 peptide binding site [polypeptide binding]; other site 1205910013016 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1205910013017 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1205910013018 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1205910013019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205910013020 dimer interface [polypeptide binding]; other site 1205910013021 conserved gate region; other site 1205910013022 putative PBP binding loops; other site 1205910013023 ABC-ATPase subunit interface; other site 1205910013024 cytosine deaminase; Provisional; Region: PRK05985 1205910013025 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1205910013026 active site 1205910013027 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 1205910013028 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06151 1205910013029 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1205910013030 active site 1205910013031 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1205910013032 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205910013033 DNA-binding site [nucleotide binding]; DNA binding site 1205910013034 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1205910013035 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1205910013036 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1205910013037 active site 1205910013038 dimer interface [polypeptide binding]; other site 1205910013039 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1205910013040 dimer interface [polypeptide binding]; other site 1205910013041 active site 1205910013042 Ion transport protein; Region: Ion_trans; pfam00520 1205910013043 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1205910013044 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205910013045 DNA-binding site [nucleotide binding]; DNA binding site 1205910013046 FCD domain; Region: FCD; pfam07729 1205910013047 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1205910013048 Cysteine-rich domain; Region: CCG; pfam02754 1205910013049 Cysteine-rich domain; Region: CCG; pfam02754 1205910013050 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1205910013051 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1205910013052 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1205910013053 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 1205910013054 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1205910013055 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 1205910013056 RNA ligase; Region: RNA_ligase; pfam09414 1205910013057 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1205910013058 Zn2+ binding site [ion binding]; other site 1205910013059 Mg2+ binding site [ion binding]; other site 1205910013060 AAA domain; Region: AAA_33; pfam13671 1205910013061 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1205910013062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910013063 H+ Antiporter protein; Region: 2A0121; TIGR00900 1205910013064 AAA ATPase domain; Region: AAA_16; pfam13191 1205910013065 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1205910013066 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1205910013067 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1205910013068 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1205910013069 radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269 1205910013070 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205910013071 FeS/SAM binding site; other site 1205910013072 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1205910013073 classical (c) SDRs; Region: SDR_c; cd05233 1205910013074 NAD(P) binding site [chemical binding]; other site 1205910013075 active site 1205910013076 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 1205910013077 hypothetical protein; Provisional; Region: PRK04233 1205910013078 SEC-C motif; Region: SEC-C; pfam02810 1205910013079 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205910013080 catalytic core [active] 1205910013081 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1205910013082 nudix motif; other site 1205910013083 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1205910013084 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1205910013085 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1205910013086 Protein of unknown function (DUF419); Region: DUF419; cl15265 1205910013087 glycogen branching enzyme; Provisional; Region: PRK14705 1205910013088 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1205910013089 Sodium Bile acid symporter family; Region: SBF; pfam01758 1205910013090 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1205910013091 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910013092 Walker A/P-loop; other site 1205910013093 ATP binding site [chemical binding]; other site 1205910013094 Q-loop/lid; other site 1205910013095 ABC transporter signature motif; other site 1205910013096 Walker B; other site 1205910013097 D-loop; other site 1205910013098 H-loop/switch region; other site 1205910013099 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910013100 Walker A/P-loop; other site 1205910013101 ATP binding site [chemical binding]; other site 1205910013102 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1205910013103 xanthine permease; Region: pbuX; TIGR03173 1205910013104 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205910013105 Cytochrome P450; Region: p450; cl12078 1205910013106 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205910013107 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1205910013108 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1205910013109 G2 box; other site 1205910013110 Switch I region; other site 1205910013111 G3 box; other site 1205910013112 Switch II region; other site 1205910013113 G4 box; other site 1205910013114 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1205910013115 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 1205910013116 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910013117 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1205910013118 ATP binding site [chemical binding]; other site 1205910013119 Mg2+ binding site [ion binding]; other site 1205910013120 G-X-G motif; other site 1205910013121 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1205910013122 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205910013123 active site 1205910013124 motif I; other site 1205910013125 motif II; other site 1205910013126 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205910013127 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 1205910013128 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205910013129 catalytic core [active] 1205910013130 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1205910013131 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1205910013132 active site 1205910013133 catalytic tetrad [active] 1205910013134 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1205910013135 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1205910013136 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1205910013137 FAD binding domain; Region: FAD_binding_4; pfam01565 1205910013138 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1205910013139 MarR family; Region: MarR_2; cl17246 1205910013140 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1205910013141 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1205910013142 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1205910013143 classical (c) SDRs; Region: SDR_c; cd05233 1205910013144 NAD(P) binding site [chemical binding]; other site 1205910013145 active site 1205910013146 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 1205910013147 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1205910013148 NAD binding site [chemical binding]; other site 1205910013149 homotetramer interface [polypeptide binding]; other site 1205910013150 homodimer interface [polypeptide binding]; other site 1205910013151 substrate binding site [chemical binding]; other site 1205910013152 active site 1205910013153 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205910013154 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1205910013155 NAD(P) binding site [chemical binding]; other site 1205910013156 active site 1205910013157 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205910013158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910013159 active site 1205910013160 phosphorylation site [posttranslational modification] 1205910013161 intermolecular recognition site; other site 1205910013162 dimerization interface [polypeptide binding]; other site 1205910013163 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205910013164 dimerization interface [polypeptide binding]; other site 1205910013165 DNA binding residues [nucleotide binding] 1205910013166 Histidine kinase; Region: HisKA_3; pfam07730 1205910013167 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1205910013168 ATP binding site [chemical binding]; other site 1205910013169 Mg2+ binding site [ion binding]; other site 1205910013170 G-X-G motif; other site 1205910013171 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1205910013172 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1205910013173 Walker A/P-loop; other site 1205910013174 ATP binding site [chemical binding]; other site 1205910013175 Q-loop/lid; other site 1205910013176 ABC transporter signature motif; other site 1205910013177 Walker B; other site 1205910013178 D-loop; other site 1205910013179 H-loop/switch region; other site 1205910013180 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1205910013181 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1205910013182 FtsX-like permease family; Region: FtsX; pfam02687 1205910013183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910013184 putative substrate translocation pore; other site 1205910013185 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1205910013186 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1205910013187 Ligand binding site; other site 1205910013188 Putative Catalytic site; other site 1205910013189 DXD motif; other site 1205910013190 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1205910013191 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1205910013192 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1205910013193 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1205910013194 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1205910013195 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205910013196 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205910013197 active site 1205910013198 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1205910013199 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1205910013200 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1205910013201 dimerization interface [polypeptide binding]; other site 1205910013202 substrate binding pocket [chemical binding]; other site 1205910013203 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1205910013204 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1205910013205 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1205910013206 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1205910013207 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1205910013208 HAMP domain; Region: HAMP; pfam00672 1205910013209 dimerization interface [polypeptide binding]; other site 1205910013210 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1205910013211 dimer interface [polypeptide binding]; other site 1205910013212 phosphorylation site [posttranslational modification] 1205910013213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910013214 ATP binding site [chemical binding]; other site 1205910013215 Mg2+ binding site [ion binding]; other site 1205910013216 G-X-G motif; other site 1205910013217 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 1205910013218 Predicted permease; Region: DUF318; cl17795 1205910013219 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1205910013220 amino acid carrier protein; Region: agcS; TIGR00835 1205910013221 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1205910013222 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1205910013223 ATP binding site [chemical binding]; other site 1205910013224 Mg++ binding site [ion binding]; other site 1205910013225 motif III; other site 1205910013226 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205910013227 nucleotide binding region [chemical binding]; other site 1205910013228 ATP-binding site [chemical binding]; other site 1205910013229 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1205910013230 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205910013231 substrate binding site [chemical binding]; other site 1205910013232 oxyanion hole (OAH) forming residues; other site 1205910013233 trimer interface [polypeptide binding]; other site 1205910013234 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1205910013235 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910013236 Walker A/P-loop; other site 1205910013237 ATP binding site [chemical binding]; other site 1205910013238 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1205910013239 ABC transporter; Region: ABC_tran_2; pfam12848 1205910013240 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1205910013241 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1205910013242 hypothetical protein; Provisional; Region: PRK11770 1205910013243 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1205910013244 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1205910013245 Transcription factor WhiB; Region: Whib; pfam02467 1205910013246 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1205910013247 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1205910013248 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1205910013249 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910013250 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1205910013251 putative substrate translocation pore; other site 1205910013252 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1205910013253 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1205910013254 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1205910013255 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1205910013256 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1205910013257 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1205910013258 Active Sites [active] 1205910013259 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1205910013260 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1205910013261 putative active site [active] 1205910013262 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1205910013263 putative active site [active] 1205910013264 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1205910013265 helicase-primase primase subunit; Provisional; Region: PHA03119 1205910013266 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 1205910013267 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1205910013268 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1205910013269 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1205910013270 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205910013271 active site 1205910013272 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1205910013273 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1205910013274 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1205910013275 active site 1205910013276 catalytic site [active] 1205910013277 hypothetical protein; Provisional; Region: PRK14059 1205910013278 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1205910013279 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1205910013280 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205910013281 DNA-binding site [nucleotide binding]; DNA binding site 1205910013282 UTRA domain; Region: UTRA; pfam07702 1205910013283 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1205910013284 SelR domain; Region: SelR; pfam01641 1205910013285 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1205910013286 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1205910013287 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 1205910013288 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1205910013289 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205910013290 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 1205910013291 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1205910013292 substrate binding site [chemical binding]; other site 1205910013293 active site 1205910013294 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1205910013295 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1205910013296 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1205910013297 catalytic site [active] 1205910013298 putative active site [active] 1205910013299 putative substrate binding site [chemical binding]; other site 1205910013300 HRDC domain; Region: HRDC; pfam00570 1205910013301 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1205910013302 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1205910013303 binding surface 1205910013304 TPR motif; other site 1205910013305 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1205910013306 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1205910013307 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1205910013308 TPR motif; other site 1205910013309 binding surface 1205910013310 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1205910013311 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1205910013312 dimer interface [polypeptide binding]; other site 1205910013313 active site 1205910013314 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205910013315 substrate binding site [chemical binding]; other site 1205910013316 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1205910013317 oxyanion hole (OAH) forming residues; other site 1205910013318 trimer interface [polypeptide binding]; other site 1205910013319 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1205910013320 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1205910013321 MMPL family; Region: MMPL; pfam03176 1205910013322 MMPL family; Region: MMPL; pfam03176 1205910013323 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910013324 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910013325 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1205910013326 ferredoxin-NADP+ reductase; Region: PLN02852 1205910013327 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1205910013328 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1205910013329 TPP-binding site; other site 1205910013330 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1205910013331 PYR/PP interface [polypeptide binding]; other site 1205910013332 dimer interface [polypeptide binding]; other site 1205910013333 TPP binding site [chemical binding]; other site 1205910013334 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1205910013335 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1205910013336 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1205910013337 hypothetical protein; Provisional; Region: PRK06547 1205910013338 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 1205910013339 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 1205910013340 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205910013341 active site 1205910013342 ATP binding site [chemical binding]; other site 1205910013343 substrate binding site [chemical binding]; other site 1205910013344 activation loop (A-loop); other site 1205910013345 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205910013346 Protein kinase domain; Region: Pkinase; pfam00069 1205910013347 active site 1205910013348 ATP binding site [chemical binding]; other site 1205910013349 substrate binding site [chemical binding]; other site 1205910013350 activation loop (A-loop); other site 1205910013351 aconitate hydratase; Validated; Region: PRK09277 1205910013352 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1205910013353 substrate binding site [chemical binding]; other site 1205910013354 ligand binding site [chemical binding]; other site 1205910013355 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1205910013356 substrate binding site [chemical binding]; other site 1205910013357 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1205910013358 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205910013359 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1205910013360 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205910013361 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205910013362 DNA binding residues [nucleotide binding] 1205910013363 Putative zinc-finger; Region: zf-HC2; pfam13490 1205910013364 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1205910013365 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910013366 Walker A/P-loop; other site 1205910013367 ATP binding site [chemical binding]; other site 1205910013368 Q-loop/lid; other site 1205910013369 ABC transporter signature motif; other site 1205910013370 Walker B; other site 1205910013371 D-loop; other site 1205910013372 H-loop/switch region; other site 1205910013373 Protein of unknown function (DUF1326); Region: DUF1326; pfam07040 1205910013374 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1205910013375 EamA-like transporter family; Region: EamA; pfam00892 1205910013376 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cl08497 1205910013377 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1205910013378 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cl17348 1205910013379 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 1205910013380 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044 1205910013381 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cl09719 1205910013382 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1205910013383 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1205910013384 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1205910013385 structural tetrad; other site 1205910013386 Domain of unknown function (DUF427); Region: DUF427; pfam04248 1205910013387 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 1205910013388 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1205910013389 TRAM domain; Region: TRAM; pfam01938 1205910013390 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1205910013391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1205910013392 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1205910013393 TrkA-N domain; Region: TrkA_N; pfam02254 1205910013394 TrkA-C domain; Region: TrkA_C; pfam02080 1205910013395 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1205910013396 TrkA-N domain; Region: TrkA_N; pfam02254 1205910013397 TrkA-C domain; Region: TrkA_C; pfam02080 1205910013398 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1205910013399 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 1205910013400 reactive center loop; other site 1205910013401 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1205910013402 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1205910013403 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1205910013404 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1205910013405 trimer interface [polypeptide binding]; other site 1205910013406 active site 1205910013407 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 1205910013408 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1205910013409 active site 1205910013410 HIGH motif; other site 1205910013411 nucleotide binding site [chemical binding]; other site 1205910013412 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1205910013413 active site 1205910013414 KMSKS motif; other site 1205910013415 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1205910013416 tRNA binding surface [nucleotide binding]; other site 1205910013417 anticodon binding site; other site 1205910013418 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 1205910013419 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1205910013420 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1205910013421 dimerization interface [polypeptide binding]; other site 1205910013422 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1205910013423 dimer interface [polypeptide binding]; other site 1205910013424 phosphorylation site [posttranslational modification] 1205910013425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205910013426 ATP binding site [chemical binding]; other site 1205910013427 Mg2+ binding site [ion binding]; other site 1205910013428 G-X-G motif; other site 1205910013429 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205910013430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205910013431 active site 1205910013432 phosphorylation site [posttranslational modification] 1205910013433 intermolecular recognition site; other site 1205910013434 dimerization interface [polypeptide binding]; other site 1205910013435 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205910013436 DNA binding site [nucleotide binding] 1205910013437 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1205910013438 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1205910013439 active site 1205910013440 dimerization interface [polypeptide binding]; other site 1205910013441 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1205910013442 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1205910013443 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1205910013444 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1205910013445 ferrochelatase; Reviewed; Region: hemH; PRK00035 1205910013446 C-terminal domain interface [polypeptide binding]; other site 1205910013447 active site 1205910013448 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1205910013449 active site 1205910013450 N-terminal domain interface [polypeptide binding]; other site 1205910013451 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 1205910013452 FAD binding domain; Region: FAD_binding_4; pfam01565 1205910013453 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1205910013454 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1205910013455 Predicted membrane protein [Function unknown]; Region: COG3428 1205910013456 Bacterial PH domain; Region: DUF304; pfam03703 1205910013457 Bacterial PH domain; Region: DUF304; pfam03703 1205910013458 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1205910013459 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205910013460 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1205910013461 Walker A/P-loop; other site 1205910013462 ATP binding site [chemical binding]; other site 1205910013463 Q-loop/lid; other site 1205910013464 ABC transporter signature motif; other site 1205910013465 Walker B; other site 1205910013466 D-loop; other site 1205910013467 H-loop/switch region; other site 1205910013468 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1205910013469 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1205910013470 DNA binding site [nucleotide binding] 1205910013471 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1205910013472 Predicted ATPase [General function prediction only]; Region: COG3903 1205910013473 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1205910013474 substrate binding site [chemical binding]; other site 1205910013475 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1205910013476 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1205910013477 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1205910013478 anti sigma factor interaction site; other site 1205910013479 regulatory phosphorylation site [posttranslational modification]; other site 1205910013480 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1205910013481 active site clefts [active] 1205910013482 zinc binding site [ion binding]; other site 1205910013483 dimer interface [polypeptide binding]; other site 1205910013484 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1205910013485 Peptidase family M23; Region: Peptidase_M23; pfam01551 1205910013486 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1205910013487 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1205910013488 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1205910013489 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1205910013490 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205910013491 catalytic core [active] 1205910013492 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1205910013493 Putative zinc ribbon domain; Region: DUF164; pfam02591 1205910013494 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1205910013495 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1205910013496 Predicted transcriptional regulator [Transcription]; Region: COG2378 1205910013497 WYL domain; Region: WYL; pfam13280 1205910013498 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1205910013499 FAD binding domain; Region: FAD_binding_4; pfam01565 1205910013500 AP endonuclease family 2; Region: AP2Ec; smart00518 1205910013501 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1205910013502 AP (apurinic/apyrimidinic) site pocket; other site 1205910013503 DNA interaction; other site 1205910013504 Metal-binding active site; metal-binding site 1205910013505 H+ Antiporter protein; Region: 2A0121; TIGR00900 1205910013506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205910013507 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205910013508 dimerization interface [polypeptide binding]; other site 1205910013509 putative DNA binding site [nucleotide binding]; other site 1205910013510 putative Zn2+ binding site [ion binding]; other site 1205910013511 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1205910013512 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1205910013513 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1205910013514 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1205910013515 RNA binding site [nucleotide binding]; other site 1205910013516 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1205910013517 synthetase active site [active] 1205910013518 NTP binding site [chemical binding]; other site 1205910013519 metal binding site [ion binding]; metal-binding site 1205910013520 Scramblase; Region: Scramblase; pfam03803 1205910013521 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205910013522 Coenzyme A binding pocket [chemical binding]; other site 1205910013523 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1205910013524 classical (c) SDRs; Region: SDR_c; cd05233 1205910013525 NAD(P) binding site [chemical binding]; other site 1205910013526 active site 1205910013527 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205910013528 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205910013529 active site 1205910013530 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205910013531 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205910013532 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1205910013533 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1205910013534 Walker A/P-loop; other site 1205910013535 ATP binding site [chemical binding]; other site 1205910013536 Q-loop/lid; other site 1205910013537 ABC transporter signature motif; other site 1205910013538 Walker B; other site 1205910013539 D-loop; other site 1205910013540 H-loop/switch region; other site 1205910013541 FecCD transport family; Region: FecCD; pfam01032 1205910013542 dimer interface [polypeptide binding]; other site 1205910013543 putative PBP binding regions; other site 1205910013544 ABC-ATPase subunit interface; other site 1205910013545 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1205910013546 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1205910013547 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1205910013548 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1205910013549 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1205910013550 siderophore binding site; other site 1205910013551 hypothetical protein; Provisional; Region: PRK06753 1205910013552 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1205910013553 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1205910013554 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1205910013555 Ca binding site [ion binding]; other site 1205910013556 active site 1205910013557 catalytic site [active] 1205910013558 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1205910013559 H+ Antiporter protein; Region: 2A0121; TIGR00900 1205910013560 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1205910013561 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1205910013562 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1205910013563 RibD C-terminal domain; Region: RibD_C; cl17279 1205910013564 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1205910013565 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1205910013566 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1205910013567 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1205910013568 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1205910013569 DNA binding site [nucleotide binding] 1205910013570 active site 1205910013571 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1205910013572 active site 1205910013573 Zn binding site [ion binding]; other site 1205910013574 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 1205910013575 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1205910013576 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 1205910013577 dimer interface [polypeptide binding]; other site 1205910013578 catalytic triad [active] 1205910013579 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1205910013580 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 1205910013581 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1205910013582 putative active site [active] 1205910013583 putative metal binding site [ion binding]; other site 1205910013584 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1205910013585 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1205910013586 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1205910013587 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1205910013588 dimer interface [polypeptide binding]; other site 1205910013589 active site 1205910013590 CoA binding pocket [chemical binding]; other site 1205910013591 acyl carrier protein; Provisional; Region: acpP; PRK00982 1205910013592 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1205910013593 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1205910013594 dimer interface [polypeptide binding]; other site 1205910013595 active site 1205910013596 EAL domain; Region: EAL; pfam00563 1205910013597 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1205910013598 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 1205910013599 active site 1205910013600 catalytic triad [active] 1205910013601 oxyanion hole [active] 1205910013602 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 1205910013603 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1205910013604 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1205910013605 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1205910013606 trimerization site [polypeptide binding]; other site 1205910013607 active site 1205910013608 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1205910013609 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1205910013610 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205910013611 catalytic residue [active] 1205910013612 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1205910013613 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1205910013614 Walker A/P-loop; other site 1205910013615 ATP binding site [chemical binding]; other site 1205910013616 Q-loop/lid; other site 1205910013617 ABC transporter signature motif; other site 1205910013618 Walker B; other site 1205910013619 D-loop; other site 1205910013620 H-loop/switch region; other site 1205910013621 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1205910013622 [2Fe-2S] cluster binding site [ion binding]; other site 1205910013623 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1205910013624 FeS assembly protein SufD; Region: sufD; TIGR01981 1205910013625 FeS assembly protein SufB; Region: sufB; TIGR01980 1205910013626 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1205910013627 Predicted transcriptional regulator [Transcription]; Region: COG2345 1205910013628 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205910013629 putative DNA binding site [nucleotide binding]; other site 1205910013630 putative Zn2+ binding site [ion binding]; other site 1205910013631 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1205910013632 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1205910013633 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1205910013634 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 1205910013635 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 1205910013636 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1205910013637 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205910013638 dimerization interface [polypeptide binding]; other site 1205910013639 putative DNA binding site [nucleotide binding]; other site 1205910013640 putative Zn2+ binding site [ion binding]; other site 1205910013641 Protease prsW family; Region: PrsW-protease; pfam13367 1205910013642 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1205910013643 UbiA prenyltransferase family; Region: UbiA; pfam01040 1205910013644 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1205910013645 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1205910013646 TPP-binding site [chemical binding]; other site 1205910013647 dimer interface [polypeptide binding]; other site 1205910013648 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1205910013649 PYR/PP interface [polypeptide binding]; other site 1205910013650 dimer interface [polypeptide binding]; other site 1205910013651 TPP binding site [chemical binding]; other site 1205910013652 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1205910013653 putative active site [active] 1205910013654 transaldolase; Provisional; Region: PRK03903 1205910013655 catalytic residue [active] 1205910013656 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1205910013657 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1205910013658 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1205910013659 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1205910013660 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 1205910013661 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1205910013662 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1205910013663 putative active site [active] 1205910013664 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1205910013665 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1205910013666 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1205910013667 intermolecular salt bridges; other site 1205910013668 RHS Repeat; Region: RHS_repeat; pfam05593 1205910013669 RHS Repeat; Region: RHS_repeat; cl11982 1205910013670 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1205910013671 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1205910013672 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1205910013673 intermolecular salt bridges; other site 1205910013674 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 1205910013675 Cupin; Region: Cupin_6; pfam12852 1205910013676 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1205910013677 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1205910013678 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1205910013679 TAP-like protein; Region: Abhydrolase_4; pfam08386 1205910013680 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1205910013681 TAP-like protein; Region: Abhydrolase_4; pfam08386 1205910013682 Nuclease-related domain; Region: NERD; pfam08378 1205910013683 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817 1205910013684 CRISPR-associated protein; Region: TIGR03986 1205910013685 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 1205910013686 Alpha-kinase family; Region: Alpha_kinase; cl03728 1205910013687 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1205910013688 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1205910013689 Na binding site [ion binding]; other site 1205910013690 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1205910013691 imidazolonepropionase; Provisional; Region: PRK14085 1205910013692 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1205910013693 active site 1205910013694 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 1205910013695 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1205910013696 active site 1205910013697 allantoate amidohydrolase; Reviewed; Region: PRK09290 1205910013698 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1205910013699 active site 1205910013700 metal binding site [ion binding]; metal-binding site 1205910013701 dimer interface [polypeptide binding]; other site 1205910013702 urocanate hydratase; Provisional; Region: PRK05414 1205910013703 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1205910013704 active sites [active] 1205910013705 tetramer interface [polypeptide binding]; other site 1205910013706 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1205910013707 putative active site [active] 1205910013708 homotetrameric interface [polypeptide binding]; other site 1205910013709 metal binding site [ion binding]; metal-binding site 1205910013710 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1205910013711 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1205910013712 Bacterial transcriptional regulator; Region: IclR; pfam01614 1205910013713 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1205910013714 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1205910013715 triosephosphate isomerase; Provisional; Region: PRK14567 1205910013716 substrate binding site [chemical binding]; other site 1205910013717 dimer interface [polypeptide binding]; other site 1205910013718 catalytic triad [active] 1205910013719 Phosphoglycerate kinase; Region: PGK; pfam00162 1205910013720 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1205910013721 substrate binding site [chemical binding]; other site 1205910013722 hinge regions; other site 1205910013723 ADP binding site [chemical binding]; other site 1205910013724 catalytic site [active] 1205910013725 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1205910013726 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1205910013727 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1205910013728 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1205910013729 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1205910013730 Protein of unknown function, DUF488; Region: DUF488; cl01246 1205910013731 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1205910013732 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1205910013733 phosphate binding site [ion binding]; other site 1205910013734 putative substrate binding pocket [chemical binding]; other site 1205910013735 dimer interface [polypeptide binding]; other site 1205910013736 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1205910013737 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1205910013738 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1205910013739 GIY-YIG motif/motif A; other site 1205910013740 active site 1205910013741 catalytic site [active] 1205910013742 putative DNA binding site [nucleotide binding]; other site 1205910013743 metal binding site [ion binding]; metal-binding site 1205910013744 UvrB/uvrC motif; Region: UVR; pfam02151 1205910013745 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1205910013746 minor groove reading motif; other site 1205910013747 Helix-hairpin-helix motif; Region: HHH; pfam00633 1205910013748 helix-hairpin-helix signature motif; other site 1205910013749 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1205910013750 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1205910013751 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1205910013752 iron-sulfur cluster [ion binding]; other site 1205910013753 [2Fe-2S] cluster binding site [ion binding]; other site 1205910013754 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1205910013755 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1205910013756 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1205910013757 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1205910013758 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1205910013759 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1205910013760 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1205910013761 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1205910013762 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1205910013763 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 1205910013764 Thiamine pyrophosphokinase; Region: TPK; cl08415 1205910013765 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 1205910013766 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1205910013767 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1205910013768 Walker A/P-loop; other site 1205910013769 ATP binding site [chemical binding]; other site 1205910013770 Q-loop/lid; other site 1205910013771 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1205910013772 ABC transporter signature motif; other site 1205910013773 Walker B; other site 1205910013774 D-loop; other site 1205910013775 H-loop/switch region; other site 1205910013776 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1205910013777 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1205910013778 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1205910013779 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1205910013780 RNA binding surface [nucleotide binding]; other site 1205910013781 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205910013782 S-adenosylmethionine binding site [chemical binding]; other site 1205910013783 Membrane fusogenic activity; Region: BMFP; cl01115 1205910013784 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1205910013785 Uncharacterized conserved protein [Function unknown]; Region: COG4198 1205910013786 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 1205910013787 Uncharacterized conserved protein [Function unknown]; Region: COG4198 1205910013788 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 1205910013789 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1205910013790 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205910013791 active site 1205910013792 motif I; other site 1205910013793 motif II; other site 1205910013794 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1205910013795 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1205910013796 generic binding surface II; other site 1205910013797 generic binding surface I; other site 1205910013798 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1205910013799 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1205910013800 nudix motif; other site 1205910013801 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321